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Aliases for SENP2 Gene

Aliases for SENP2 Gene

  • SUMO1/Sentrin/SMT3 Specific Peptidase 2 2 3
  • SMT3IP2 3 4 6
  • AXAM2 3 4 6
  • SUMO1/Sentrin/SMT3 Specific Protease 2 2 3
  • Sentrin/SUMO-Specific Protease SENP2 3 4
  • SMT3-Specific Isopeptidase 2 3 4
  • EC 3.4.22.68 4 63
  • KIAA1331 4 6
  • Sentrin-Specific Protease 2 3
  • EC 3.4.22 63

External Ids for SENP2 Gene

Previous GeneCards Identifiers for SENP2 Gene

  • GC03P182095
  • GC03M186470
  • GC03P186706
  • GC03P186624
  • GC03P186786
  • GC03P185301
  • GC03P182713

Summaries for SENP2 Gene

Entrez Gene Summary for SENP2 Gene

  • SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]

GeneCards Summary for SENP2 Gene

SENP2 (SUMO1/Sentrin/SMT3 Specific Peptidase 2) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include protein domain specific binding and SUMO-specific protease activity. An important paralog of this gene is SENP5.

UniProtKB/Swiss-Prot for SENP2 Gene

  • Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1.

Gene Wiki entry for SENP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SENP2 Gene

Genomics for SENP2 Gene

Regulatory Elements for SENP2 Gene

Genomic Location for SENP2 Gene

Start:
185,582,496 bp from pter
End:
185,633,551 bp from pter
Size:
51,056 bases
Orientation:
Plus strand

Genomic View for SENP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SENP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SENP2 Gene

Proteins for SENP2 Gene

  • Protein details for SENP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC62-SENP2_HUMAN
    Recommended name:
    Sentrin-specific protease 2
    Protein Accession:
    Q9HC62
    Secondary Accessions:
    • B4DQ42
    • Q8IW97
    • Q96SR2
    • Q9P2L5

    Protein attributes for SENP2 Gene

    Size:
    589 amino acids
    Molecular mass:
    67855 Da
    Quaternary structure:
    • Binds to SUMO2 and SUMO3 (By similarity). Interacts with the C-terminal domain of NUP153 via its N-terminus. Interacts with MTA1.

    Three dimensional structures from OCA and Proteopedia for SENP2 Gene

    Alternative splice isoforms for SENP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SENP2 Gene

Proteomics data for SENP2 Gene at MOPED

Selected DME Specific Peptides for SENP2 Gene

Post-translational modifications for SENP2 Gene

  • Polyubiquitinated; which leads to proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SENP2 Gene

Domains for SENP2 Gene

Protein Domains for SENP2 Gene

Suggested Antigen Peptide Sequences for SENP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HC62

UniProtKB/Swiss-Prot:

SENP2_HUMAN :
  • Q9HC62
Domain:
  • The N-terminus is necessary and sufficient for nuclear envelope targeting
Family:
  • Belongs to the peptidase C48 family.
genes like me logo Genes that share domains with SENP2: view

No data available for Gene Families for SENP2 Gene

Function for SENP2 Gene

Molecular function for SENP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly- -Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein
UniProtKB/Swiss-Prot Function: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1.

Enzyme Numbers (IUBMB) for SENP2 Gene

Gene Ontology (GO) - Molecular Function for SENP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11896061
GO:0008234 cysteine-type peptidase activity --
GO:0016929 SUMO-specific protease activity IDA 11896061
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with SENP2: view
genes like me logo Genes that share phenotypes with SENP2: view

miRNA for SENP2 Gene

miRTarBase miRNAs that target SENP2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SENP2 Gene

Localization for SENP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SENP2 Gene

Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm. Note=Shuttles between cytoplasm and nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SENP2 Gene COMPARTMENTS Subcellular localization image for SENP2 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for SENP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005643 nuclear pore IDA 12192048
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm --
GO:0016604 nuclear body --
genes like me logo Genes that share ontologies with SENP2: view

Pathways for SENP2 Gene

genes like me logo Genes that share pathways with SENP2: view

Pathways by source for SENP2 Gene

Gene Ontology (GO) - Biological Process for SENP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0006508 proteolysis --
GO:0007507 heart development IEA --
GO:0009950 dorsal/ventral axis specification IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SENP2: view

Transcripts for SENP2 Gene

Unigene Clusters for SENP2 Gene

SUMO1/sentrin/SMT3 specific peptidase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SENP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^
SP1: - - - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7:
SP8: - - -
SP9: -
SP10: -
SP11:

ExUns: 14 ^ 15 ^ 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for SENP2 Gene

GeneLoc Exon Structure for
SENP2
ECgene alternative splicing isoforms for
SENP2

Expression for SENP2 Gene

mRNA expression in normal human tissues for SENP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SENP2 Gene

SOURCE GeneReport for Unigene cluster for SENP2 Gene Hs.401388

genes like me logo Genes that share expressions with SENP2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SENP2 Gene

Orthologs for SENP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SENP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SENP2 35
  • 99.49 (n)
  • 99.15 (a)
SENP2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SENP2 35
  • 92.76 (n)
  • 91 (a)
SENP2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SENP2 35
  • 93.38 (n)
  • 93.38 (a)
SENP2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Senp2 35
  • 88.36 (n)
  • 88.42 (a)
Senp2 16
Senp2 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 71 (a)
OneToMany
-- 36
  • 38 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SENP2 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Senp2 35
  • 88.47 (n)
  • 87.39 (a)
chicken
(Gallus gallus)
Aves SENP2 35
  • 58.21 (n)
  • 51.45 (a)
SENP2 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SENP2 36
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii senp2 35
  • 46.51 (n)
  • 37.77 (a)
senp2 36
  • 30 (a)
OneToOne
wufb78c01 35
fruit fly
(Drosophila melanogaster)
Insecta CG11023 36
  • 24 (a)
ManyToMany
CG32110 36
  • 27 (a)
ManyToMany
Ulp1 36
  • 10 (a)
ManyToMany
Ulp1 37
  • 43 (a)
CG11023 37
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea T10F2.3 37
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ULP1 36
  • 18 (a)
OneToMany
Species with no ortholog for SENP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SENP2 Gene

ENSEMBL:
Gene Tree for SENP2 (if available)
TreeFam:
Gene Tree for SENP2 (if available)

Paralogs for SENP2 Gene

Paralogs for SENP2 Gene

Selected SIMAP similar genes for SENP2 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with SENP2: view

Variants for SENP2 Gene

Sequence variations from dbSNP and Humsavar for SENP2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1464579 -- 185,601,858(-) GAGTT(C/T)GAGAC intron-variant
rs1464580 -- 185,601,742(-) GAAAA(C/T)TGCTT intron-variant
rs1568664 -- 185,594,443(+) TCAAC(C/T)GAGGA intron-variant
rs1823238 -- 185,624,182(+) TGCAT(A/G)CTTTT intron-variant
rs2034343 -- 185,620,066(-) aaatt(A/T)aaaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SENP2 Gene

Variant ID Type Subtype PubMed ID
nsv878066 CNV Gain 21882294
nsv4148 CNV Insertion 18451855

Relevant External Links for SENP2 Gene

HapMap Linkage Disequilibrium report
SENP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SENP2 Gene

Disorders for SENP2 Gene

No disorders were found for SENP2 Gene.

No data available for UniProtKB/Swiss-Prot for SENP2 Gene

Publications for SENP2 Gene

  1. Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat axam, which is an axin-binding protein promoting beta-catenin degradation. (PMID: 11489887) Nishida T. … Yasuda H. (J. Biol. Chem. 2001) 2 3 23
  2. Association of the human SUMO-1 protease SENP2 with the nuclear pore. (PMID: 11896061) Hang J. … Dasso M. (J. Biol. Chem. 2002) 2 3 4
  3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. Nucleocytoplasmic shuttling modulates activity and ubiquitination- dependent turnover of SUMO-specific protease 2. (PMID: 16738331) Itahana Y. … Zhang Y. (Mol. Cell. Biol. 2006) 3 4
  5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4

Products for SENP2 Gene

  • Addgene plasmids for SENP2

Sources for SENP2 Gene

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