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Aliases for SENP2 Gene

Aliases for SENP2 Gene

  • SUMO1/Sentrin/SMT3 Specific Peptidase 2 2 3 5
  • SUMO1/Sentrin/SMT3 Specific Protease 2 2 3
  • Sentrin/SUMO-Specific Protease SENP2 3 4
  • SMT3-Specific Isopeptidase 2 3 4
  • EC 3.4.22.68 4 63
  • SMT3IP2 3 4
  • AXAM2 3 4
  • EC 3.4.22 63
  • KIAA1331 4

External Ids for SENP2 Gene

Previous GeneCards Identifiers for SENP2 Gene

  • GC03P182095
  • GC03M186470
  • GC03P186706
  • GC03P186624
  • GC03P186786
  • GC03P185301
  • GC03P182713

Summaries for SENP2 Gene

Entrez Gene Summary for SENP2 Gene

  • SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]

GeneCards Summary for SENP2 Gene

SENP2 (SUMO1/Sentrin/SMT3 Specific Peptidase 2) is a Protein Coding gene. Among its related pathways are RNA transport and Wnt signaling pathway (KEGG). GO annotations related to this gene include protein domain specific binding and SUMO-specific protease activity. An important paralog of this gene is SENP3.

UniProtKB/Swiss-Prot for SENP2 Gene

  • Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620).

Gene Wiki entry for SENP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SENP2 Gene

Genomics for SENP2 Gene

Regulatory Elements for SENP2 Gene

Enhancers for SENP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SENP2 on UCSC Golden Path with GeneCards custom track

Promoters for SENP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SENP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SENP2 Gene

Chromosome:
3
Start:
185,582,496 bp from pter
End:
185,633,551 bp from pter
Size:
51,056 bases
Orientation:
Plus strand

Genomic View for SENP2 Gene

Genes around SENP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SENP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SENP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SENP2 Gene

Proteins for SENP2 Gene

  • Protein details for SENP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC62-SENP2_HUMAN
    Recommended name:
    Sentrin-specific protease 2
    Protein Accession:
    Q9HC62
    Secondary Accessions:
    • B4DQ42
    • Q8IW97
    • Q96SR2
    • Q9P2L5

    Protein attributes for SENP2 Gene

    Size:
    589 amino acids
    Molecular mass:
    67855 Da
    Quaternary structure:
    • Binds to SUMO2 and SUMO3 (By similarity). Interacts with the C-terminal domain of NUP153 via its N-terminus. Interacts with MTA1.

    Three dimensional structures from OCA and Proteopedia for SENP2 Gene

    Alternative splice isoforms for SENP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SENP2 Gene

Proteomics data for SENP2 Gene at MOPED

Selected DME Specific Peptides for SENP2 Gene

Post-translational modifications for SENP2 Gene

  • Polyubiquitinated; which leads to proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SENP2 Gene

Domains & Families for SENP2 Gene

Gene Families for SENP2 Gene

Protein Domains for SENP2 Gene

Suggested Antigen Peptide Sequences for SENP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HC62

UniProtKB/Swiss-Prot:

SENP2_HUMAN :
  • The N-terminus is necessary and sufficient for nuclear envelope targeting.
  • Belongs to the peptidase C48 family.
Domain:
  • The N-terminus is necessary and sufficient for nuclear envelope targeting.
Family:
  • Belongs to the peptidase C48 family.
genes like me logo Genes that share domains with SENP2: view

Function for SENP2 Gene

Molecular function for SENP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly- -Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein.
UniProtKB/Swiss-Prot Function:
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620).

Enzyme Numbers (IUBMB) for SENP2 Gene

Gene Ontology (GO) - Molecular Function for SENP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IBA --
genes like me logo Genes that share ontologies with SENP2: view
genes like me logo Genes that share phenotypes with SENP2: view

Animal Models for SENP2 Gene

MGI Knock Outs for SENP2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SENP2

miRNA for SENP2 Gene

miRTarBase miRNAs that target SENP2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SENP2 Gene

Localization for SENP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SENP2 Gene

Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm. Note=Shuttles between cytoplasm and nucleus. {ECO:0000269 PubMed:16738331}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SENP2 Gene COMPARTMENTS Subcellular localization image for SENP2 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for SENP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016605 colocalizes_with PML body IEA,ISS --
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with SENP2: view

Pathways & Interactions for SENP2 Gene

genes like me logo Genes that share pathways with SENP2: view

Pathways by source for SENP2 Gene

Gene Ontology (GO) - Biological Process for SENP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0006508 proteolysis IEA --
GO:0007507 heart development IEA --
GO:0009950 dorsal/ventral axis specification IEA --
GO:0016055 Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with SENP2: view

No data available for SIGNOR curated interactions for SENP2 Gene

Drugs & Compounds for SENP2 Gene

(1) Drugs for SENP2 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NSC 632839 hydrochloride Pharma Isopeptidases inhibitor, Inhibitor of ubiquitin isopeptidase activity 0

(1) ApexBio Compounds for SENP2 Gene

Compound Action Cas Number
NSC 632839 hydrochloride Isopeptidases inhibitor 157654-67-6
genes like me logo Genes that share compounds with SENP2: view

Transcripts for SENP2 Gene

Unigene Clusters for SENP2 Gene

SUMO1/sentrin/SMT3 specific peptidase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SENP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^
SP1: - - - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7:
SP8: - - -
SP9: -
SP10: -
SP11:

ExUns: 14 ^ 15 ^ 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for SENP2 Gene

GeneLoc Exon Structure for
SENP2
ECgene alternative splicing isoforms for
SENP2

Expression for SENP2 Gene

mRNA expression in normal human tissues for SENP2 Gene

Protein differential expression in normal tissues from HIPED for SENP2 Gene

This gene is overexpressed in Placenta (32.7), Testis (20.8), and Ovary (15.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SENP2 Gene



SOURCE GeneReport for Unigene cluster for SENP2 Gene Hs.401388

genes like me logo Genes that share expression patterns with SENP2: view

Protein tissue co-expression partners for SENP2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SENP2 Gene

Orthologs for SENP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SENP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SENP2 35
  • 92.76 (n)
  • 91 (a)
SENP2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SENP2 35
  • 93.38 (n)
  • 93.38 (a)
SENP2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Senp2 35
  • 88.36 (n)
  • 88.42 (a)
Senp2 16
Senp2 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SENP2 35
  • 99.49 (n)
  • 99.15 (a)
SENP2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Senp2 35
  • 88.47 (n)
  • 87.39 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 71 (a)
OneToMany
-- 36
  • 38 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SENP2 36
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves SENP2 35
  • 58.21 (n)
  • 51.45 (a)
SENP2 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SENP2 36
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii senp2 35
  • 46.51 (n)
  • 37.77 (a)
wufb78c01 35
senp2 36
  • 30 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11023 37
  • 41 (a)
Ulp1 37
  • 43 (a)
CG11023 36
  • 24 (a)
ManyToMany
CG32110 36
  • 27 (a)
ManyToMany
Ulp1 36
  • 10 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea T10F2.3 37
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ULP1 36
  • 18 (a)
OneToMany
Species with no ortholog for SENP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SENP2 Gene

ENSEMBL:
Gene Tree for SENP2 (if available)
TreeFam:
Gene Tree for SENP2 (if available)

Paralogs for SENP2 Gene

Paralogs for SENP2 Gene

(2) SIMAP similar genes for SENP2 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with SENP2: view

Variants for SENP2 Gene

Sequence variations from dbSNP and Humsavar for SENP2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs6762208 - 185,613,377(+) AGAGA(A/C/T)GATGG reference, missense
rs4456898 -- 185,618,466(+) GACTA(A/G)TTACT intron-variant
rs7615486 -- 185,590,707(+) ctaaa(A/C)attaa intron-variant
rs4568175 -- 185,618,604(+) CCGGG(C/T)GCGGT intron-variant
rs4569690 -- 185,618,852(+) CCAGC(C/T)TGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SENP2 Gene

Variant ID Type Subtype PubMed ID
nsv878066 CNV Gain 21882294
nsv4148 CNV Insertion 18451855

Variation tolerance for SENP2 Gene

Residual Variation Intolerance Score: 15.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.26; 88.15% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SENP2 Gene

Disorders for SENP2 Gene

Relevant External Links for SENP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SENP2

No disorders were found for SENP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SENP2 Gene

Publications for SENP2 Gene

  1. Association of the human SUMO-1 protease SENP2 with the nuclear pore. (PMID: 11896061) Hang J. … Dasso M. (J. Biol. Chem. 2002) 2 3 4 67
  2. Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat axam, which is an axin-binding protein promoting beta-catenin degradation. (PMID: 11489887) Nishida T. … Yasuda H. (J. Biol. Chem. 2001) 2 3 23
  3. DNA damage-induced NF-I_B activation in human glioblastoma cells promotes miR-181b expression and cell proliferation. (PMID: 25633526) Xu R.X. … Xu Y.H. (Cell. Physiol. Biochem. 2015) 3
  4. Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function. (PMID: 25689261) Heo K.S. … Abe J. (J. Clin. Invest. 2015) 3
  5. SUMO-Specific Protease 2 (SENP2) Is an Important Regulator of Fatty Acid Metabolism in Skeletal Muscle. (PMID: 25784542) Koo Y.D. … Park K.S. (Diabetes 2015) 3

Products for SENP2 Gene

Sources for SENP2 Gene

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