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SENP2 Gene

protein-coding   GIFtS: 62
GCID: GC03P185301

SUMO1/Sentrin/SMT3 Specific Peptidase 2

(Previous name: SUMO1/sentrin/SMT3 specific protease 2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SUMO1/Sentrin/SMT3 Specific Peptidase 21 2     SMT3IP22 5
SUMO1/Sentrin/SMT3 Specific Protease 21 2     KIAA13313 5
Sentrin/SUMO-Specific Protease SENP22 3     Sentrin-Specific Protease 22
SMT3-Specific Isopeptidase 22 3     Axam23
EC 3.4.22.683 8     Smt3ip23
AXAM22 5     EC 3.4.228

External Ids:    HGNC: 231161   Entrez Gene: 593432   Ensembl: ENSG000001639047   OMIM: 6082615   UniProtKB: Q9HC623   

Export aliases for SENP2 gene to outside databases

Previous GC identifers: GC03P182095 GC03M186470 GC03P186706 GC03P186624 GC03P186786 GC03P182713


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SENP2 Gene:
SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins.
SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze
the deconjugation of SUMO1-containing species.(supplied by OMIM, Apr 2004)

GeneCards Summary for SENP2 Gene:
SENP2 (SUMO1/sentrin/SMT3 specific peptidase 2) is a protein-coding gene. GO annotations related to this gene include SUMO-specific protease activity and protein domain specific binding. An important paralog of this gene is SENP3.

UniProtKB/Swiss-Prot: SENP2_HUMAN, Q9HC62
Function: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1,
SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May
down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity)

Gene Wiki entry for SENP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SENP2 gene promoter:
         AhR   RFX1   GATA-3   Tal-1beta   Arnt   GATA-2   GATA-1   Evi-1   Pax-3   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSENP2 promoter sequence
   Search Chromatin IP Primers for SENP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SENP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27.2   Ensembl cytogenetic band:  3q27.2   HGNC cytogenetic band: 3q28

SENP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SENP2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P185301:  view genomic region     (about GC identifiers)

Start:
185,300,284 bp from pter      End:
185,351,339 bp from pter
Size:
51,056 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SENP2_HUMAN, Q9HC62 (See protein sequence)
Recommended Name: Sentrin-specific protease 2  
Size: 589 amino acids; 67855 Da
Subunit: Binds to SUMO2 and SUMO3 (By similarity). Interacts with the C-terminal domain of NUP153 via its
N-terminus
Selected PDB 3D structures from and Proteopedia for SENP2 (see all 7):
1TGZ (3D)        1TH0 (3D)        2IO0 (3D)        2IO1 (3D)        2IO2 (3D)        2IO3 (3D)    
Secondary accessions: Q8IW97 Q96SR2 Q9P2L5

Explore the universe of human proteins at neXtProt for SENP2: NX_Q9HC62

Explore proteomics data for SENP2 at MOPED

Post-translational modifications: 

  • Polyubiquitinated; which leads to proteasomal degradation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SENP2 (Q9HC62) (see all 6)
     MVWEILH  NGSDCGMF  DLNLLEWTH  GYQAVKRWTK 


    See SENP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_067640.2  
    ENSEMBL proteins: 
     ENSP00000399156   ENSP00000296257   ENSP00000393197   ENSP00000390229   ENSP00000388893  
     ENSP00000408114   ENSP00000399201   ENSP00000439653   ENSP00000394562  
    Reactome Protein details: Q9HC62

    SENP2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SENP2

     
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    antibodies-online proteins for SENP2 (3 products) 

     
    antibodies-online peptides for SENP2

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    antibodies-online kits for SENP2 (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003653 Peptidase_C48

    Graphical View of Domain Structure for InterPro Entry Q9HC62

    ProtoNet protein and cluster: Q9HC62

    1 Blocks protein domain: IPB003653 SUMO/Sentrin/Ubl1 specific protease

    UniProtKB/Swiss-Prot: SENP2_HUMAN, Q9HC62
    Domain: The N-terminus is necessary and sufficient for nuclear envelope targeting
    Similarity: Belongs to the peptidase C48 family


    Find genes that share domains with SENP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SENP2_HUMAN, Q9HC62
    Function: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1,
    SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May
    down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity)
    Catalytic activity: Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly- -Ala-Thr-Tyr at the
    C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the
    protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine
    of the mature SUMO and the lysine epsilon-amino group of the target protein

         Enzyme Numbers (IUBMB): EC 3.4.22.681 2 EC 3.4.222

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11896061
    GO:0008234cysteine-type peptidase activity ----
    GO:0016929SUMO-specific protease activity IDA11896061
    GO:0019904protein domain specific binding IEA--
         
    Find genes that share ontologies with SENP2           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Senp2):
     cardiovascular system  embryogenesis  homeostasis/metabolism  mortality/aging 

    Find genes that share phenotypes with SENP2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SENP2

    miRNA
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    miRTarBase miRNAs that target SENP2:
    hsa-mir-98-5p (MIRT027689), hsa-mir-30d-5p (MIRT047781)

    Block miRNA regulation of human, mouse, rat SENP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SENP2 (see all 24):
    hsa-miR-3194-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-3121-3p hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidSENP2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Addgene plasmids for SENP2 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SENP2_HUMAN, Q9HC62: Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic
    side. Cytoplasm. Note=Shuttles between cytoplasm and nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005643nuclear pore IDA12192048
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--
    GO:0016604nuclear body ----
    GO:0016605colocalizes with PML body ISS--

    Find genes that share ontologies with SENP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SENP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    2Processing and Activation of SUMO
    Processing and Activation of SUMO
    Proteolytic Processing of SUMO0.00
    SUMOylation0.00
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30
    4RNA transport
    RNA transport


    Find genes that share SuperPaths with SENP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SENP2
        Wnt Signaling Pathway NetPath


    1 Reactome Pathway for SENP2
        SUMO is proteolytically processed


    2 Kegg Pathways  (Kegg details for SENP2):
        RNA transport
    Wnt signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SENP2
    Interactions:

        GeneGlobe Interaction Network for SENP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SENP2 (Q9HC621, 2, 3 ENSP000002962574) via UniProtKB, MINT, STRING, and/or I2D (see all 92)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKBKGQ9Y6K91, 3, ENSP000003586224EBI-714881,EBI-81279 I2D: score=1 STRING: ENSP00000358622
    CDK5RAP2Q96SN82, 3, ENSP000003438184MINT-65258 I2D: score=5 STRING: ENSP00000343818
    NUP153P497903, ENSP000002620774I2D: score=2 STRING: ENSP00000262077
    SUMO3P558543, ENSP000003303434I2D: score=2 STRING: ENSP00000330343
    AXIN1O151693, ENSP000002623204I2D: score=1 STRING: ENSP00000262320
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation IEA--
    GO:0006508proteolysis ----
    GO:0007507heart development IEA--
    GO:0009950dorsal/ventral axis specification IEA--
    GO:0015031protein transport IEA--

    Find genes that share ontologies with SENP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SENP2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SENP2 gene: 
    NM_021627.2  

    Unigene Cluster for SENP2:

    SUMO1/sentrin/SMT3 specific peptidase 2
    Hs.401388  [show with all ESTs]
    Unigene Representative Sequence: NM_021627
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000430355 ENST00000465201 ENST00000296257(uc011brv.2 uc003fpn.3 uc011brw.2)
    ENST00000453532 ENST00000439684 ENST00000413407 ENST00000458551 ENST00000473760
    ENST00000459883 ENST00000478001 ENST00000476011 ENST00000444509 ENST00000483005
    ENST00000545472 ENST00000427465
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SENP2 (see all 24):
    hsa-miR-3194-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-3121-3p hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidSENP2 3' UTR sequence
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SENP2
      QuantiTect SYBR Green Assays in human, mouse, rat SENP2
      QuantiFast Probe-based Assays in human, mouse, rat SENP2

    Additional mRNA sequence: 

    AF151697.2 AK027599.1 AK074357.1 AK296744.1 AK296772.1 AK298628.1 AK304402.1 AL834380.1 
    BC018020.1 BC040609.1 

    17 DOTS entries:

    DT.446306  DT.100784573  DT.100784569  DT.97843847  DT.97785493  DT.120856137  DT.120856151  DT.86847609 
    DT.92453535  DT.100681740  DT.100727021  DT.102831613  DT.120856132  DT.120856134  DT.120856156  DT.97821649 
    DT.95235804 

    Selected AceView cDNA sequences (see all 192):

    AL834380 BC040609 BP378049 AI216084 AA588335 CA315010 CK821134 BM759473 
    CF886833 Z38481 BQ232728 AI417493 BP360516 AI249722 AI493144 AI075943 
    CB242144 AI337327 AA705377 BM723152 AA974418 BP428893 AA884653 T35283 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SENP2 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^
    SP1:                    -                                                                 -           -                             -                       -   
    SP2:                    -                 -                                                                                                                     
    SP3:                    -           -                                                                                                                           
    SP4:                    -           -     -                                                                                                                     
    SP5:                    -                 -     -                                                                                                               

    ExUns: 14 ^ 15 ^ 16 ^ 17
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for SENP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SENP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SENP2 Expression
    About this image


    SENP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    SENP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SENP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.401388
        Custom PCR Arrays for SENP2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SENP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SENP2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Senp21 , 5 SUMO/sentrin specific peptidase 21, 5 88.36(n)1
    88.42(a)1
      16 (12.98 cM)5
    758261  NM_029457.31  NP_083733.11 
     220094845 
    chicken
    (Gallus gallus)
    Aves SENP21 SUMO1/sentrin/SMT3 specific peptidase 2 58.21(n)
    51.45(a)
      424864  XM_422676.4  XP_422676.3 
    lizard
    (Anolis carolinensis)
    Reptilia SENP26
    SUMO1/sentrin/SMT3 specific peptidase 2
    47(a)
    1 ↔ 1
    3(34416214-34442597)
    zebrafish
    (Danio rerio)
    Actinopterygii wufb78c012 Transcribed sequence with weak similarity to protein refNP_067640.1 (H.sapiens) sentrin-specific protease [Homo sapiens] less 74.85(n)    AL728060.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ulp13 protein deubiquitination
    ubiquitin-specific protease less
    43(a)
    (best of 2)
      18B1   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ULP16
    Protease that specifically cleaves Smt3p protein c...
    18(a)
    1 → many
    XVI(512313-514178) YPL020C


    ENSEMBL Gene Tree for SENP2 (if available)
    TreeFam Gene Tree for SENP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SENP2 gene
    SENP32  SENP12  SENP52  
    2 SIMAP similar genes for SENP2 using alignment to 9 protein entries:     SENP2_HUMAN (see all proteins):
    SENP1    SENP5

    Find genes that share paralogs with SENP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SENP2 (see all 889)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1916681791,2
    --185302046(+) CAAACG/TTTCAG 1 -- us2k10--------
    rs130959121,2
    C,F,A,H--185302098(+) GAGGCG/AGGTGT 1 -- us2k123Minor allele frequency- A:0.41EA NS WA NA CSA 2124
    rs1843495261,2
    --185302185(+) TGTGTA/GGCTGG 1 -- us2k10--------
    rs716312671,2
    C--185302292(+) ACACAT/CACACA 1 -- us2k11Minor allele frequency- C:0.00NA 2
    rs124908851,2
    H--185302306(+) acacaC/Tacaca 1 -- us2k10--------
    rs109372221,2
    A--185302312(+) acacaC/Tacaca 1 -- us2k10--------
    rs109372231,2
    A--185302316(+) atacaC/Tacaca 1 -- us2k10--------
    rs717037111,2
    C--185302333(+) TTTAT-/TTTA  
            
    TTTAT
    1 -- us2k10--------
    rs1430477291,2
    C--185302333(+) TTTAT-/TTTA  
            
    TTTAT
    1 -- us2k10--------
    rs629599631,2
    C--185302347(+) TATTT-/A/ATTT
            
    TTTGA
    1 -- us2k11NA 2

    HapMap Linkage Disequilibrium report for SENP2 (185300284 - 185351339 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SENP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4148CNV Insertion18451855
    nsv878066CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing SENP2:
    Ovarian Cancer
    SeqTarget long-range PCR primers for resequencing SENP2
    DNA2.0 Custom Variant and Variant Library Synthesis for SENP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608261    OMIM disorders: --


    Find genes that share disorders with SENP2           About GenesLikeMe


    Export disorders for SENP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SENP2 gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with SENP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of the human SUMO-1 protease SENP2 with the nuclear pore. (PubMed id 11896061)1, 2, 3 Hang J. and Dasso M. (J. Biol. Chem. 2002)
    2. Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat axam, which is an axin-binding protein promoting beta-catenin degradation. (PubMed id 11489887)1, 3, 9 Nishida T....Yasuda H. (J. Biol. Chem. 2001)
    3. Nucleocytoplasmic shuttling modulates activity and ubiquitination- dependent turnover of SUMO-specific protease 2. (PubMed id 16738331)1, 2 Itahana Y.... Zhang Y. (Mol. Cell. Biol. 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex. (PubMed id 15296745)1, 2 Reverter D. and Lima C.D. (Structure 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex. (PubMed id 12192048)1, 2 Zhang H.... Matunis M.J. (Mol. Cell. Biol. 2002)
    8. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    9. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 59343 HGNC: 23116 AceView: SENP2 Ensembl:ENSG00000163904 euGenes: HUgn59343
    ECgene: SENP2 Kegg: 59343 H-InvDB: SENP2

    (According to HUGE)
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    HUGE: KIAA1331

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SENP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SENP2 gene:
    Search GeneIP for patents involving SENP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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