Aliases for SENP2 Gene
External Ids for SENP2 Gene
Previous GeneCards Identifiers for SENP2 Gene
SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]
GeneCards Summary for SENP2 Gene
SENP2 (SUMO1/Sentrin/SMT3 Specific Peptidase 2) is a Protein Coding gene. Among its related pathways are SUMOylation and Transport to the Golgi and subsequent modification. GO annotations related to this gene include protein domain specific binding and SUMO-specific protease activity. An important paralog of this gene is SENP1.
UniProtKB/Swiss-Prot for SENP2 Gene
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620).