Aliases for SENP2 Gene
External Ids for SENP2 Gene
Previous GeneCards Identifiers for SENP2 Gene
SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]
GeneCards Summary for SENP2 Gene
SENP2 (SUMO1/Sentrin/SMT3 Specific Peptidase 2) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Wnt signaling pathway (KEGG). GO annotations related to this gene include protein domain specific binding and SUMO-specific protease activity. An important paralog of this gene is SENP5.
UniProtKB/Swiss-Prot for SENP2 Gene
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620).