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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SENP1 Gene

protein-coding   GIFtS: 65
GCID: GC12M048436

SUMO1/Sentrin Specific Peptidase 1

(Previous name: SUMO1/sentrin specific protease 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SUMO1/Sentrin Specific Peptidase 11 2     Sentrin-Specific Protease 12
SUMO1/Sentrin Specific Protease 11 2     EC 3.4.22.683
Sentrin/SUMO-Specific Protease SENP12 3     EC 3.4.228
SuPr-22     

External Ids:    HGNC: 179271   Entrez Gene: 298432   Ensembl: ENSG000000793877   OMIM: 6121575   UniProtKB: Q9P0U33   

Export aliases for SENP1 gene to outside databases

Previous GC identifers: GC12M048451 GC12M048338 GC12M048154 GC12M046725 GC12M046722 GC12M045468


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SENP1 Gene:
This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier
(SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease
also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in
multiple transcript variants. (provided by RefSeq, Jun 2012)

GeneCards Summary for SENP1 Gene: 
SENP1 (SUMO1/sentrin specific peptidase 1) is a protein-coding gene. Diseases associated with SENP1 include teratoma, and herpes simplex, and among its related super-pathways are Proteolytic Processing of SUMO and DNA damage Role of SUMO in p53 regulation. GO annotations related to this gene include endopeptidase activity and SUMO-specific protease activity. An important paralog of this gene is SENP3.

UniProtKB/Swiss-Prot: SENP1_HUMAN, Q9P0U3
Function: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1,
SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins.
Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression
activity

Gene Wiki entry for SENP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SENP1 gene promoter:
         HOXA9B   HOXA9   AP-1   ATF-2   FOXD1   CUTL1   STAT5A   Meis-1a   c-Jun   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSENP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SENP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SENP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.1   Ensembl cytogenetic band:  12q13.11   HGNC cytogenetic band: 12q13.1

SENP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SENP1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M048436:  view genomic region     (about GC identifiers)

Start:
48,436,681 bp from pter      End:
48,500,091 bp from pter
Size:
63,411 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SENP1_HUMAN, Q9P0U3 (See protein sequence)
Recommended Name: Sentrin-specific protease 1  
Size: 644 amino acids; 73481 Da
Subcellular location: Nucleus. Cytoplasm. Note=Shuttles between cytoplasm and nucleus
6/9 PDB 3D structures from and Proteopedia for SENP1 (see all 9):
2CKG (3D)        2CKH (3D)        2G4D (3D)        2IY0 (3D)        2IY1 (3D)        2IYC (3D)    
Secondary accessions: A8K7P5 Q86XC8
Alternative splicing: 2 isoforms:  Q9P0U3-1   Q9P0U3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SENP1: NX_Q9P0U3

Explore proteomics data for SENP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P0U3

  • 4 DME Specific Peptides for SENP1 (Q9P0U3)
     MVWEILH  NGSDCGMF  GYQAVKRWTK  WLNDEIINFY 

    SENP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SENP1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001254523.1  NP_001254524.1  

    ENSEMBL proteins: 
     ENSP00000447593   ENSP00000446681   ENSP00000450076   ENSP00000447328   ENSP00000448597  
     ENSP00000004980   ENSP00000394791   ENSP00000344652  
    Reactome Protein details: Q9P0U3
    Human Recombinant Protein Products for SENP1: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SENP1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--

    SENP1 for ontologies           About GeneDecksing



    SENP1 Antibody Products: 
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    Assay Products for SENP1: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003653 Peptidase_C48

    Graphical View of Domain Structure for InterPro Entry Q9P0U3

    ProtoNet protein and cluster: Q9P0U3

    1 Blocks protein domain: IPB003653 SUMO/Sentrin/Ubl1 specific protease

    UniProtKB/Swiss-Prot: SENP1_HUMAN, Q9P0U3
    Similarity: Belongs to the peptidase C48 family


    SENP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SENP1_HUMAN, Q9P0U3
    Function: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1,
    SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins.
    Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression
    activity
    Catalytic activity: Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly- -Ala-Thr-Tyr at the
    C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the
    protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine
    of the mature SUMO and the lysine epsilon-amino group of the target protein

         Enzyme Numbers (IUBMB): EC 3.4.22.681 EC 3.4.222

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004175endopeptidase activity TAS10652325
    GO:0005515protein binding IPI--
    GO:0008234cysteine-type peptidase activity ----
    GO:0016929SUMO-specific protease activity ISS--
         
    SENP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SENP1:
     Decreased viability of wild-ty 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SENP1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SENP1 
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    SwitchGear 3'UTR luciferase reporter plasmidSENP1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SENP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1SUMOylation
    SUMOylation0.67
    Processing and Activation of SUMO0.67
    Proteolytic Processing of SUMO0.67
    2DNA damage Role of SUMO in p53 regulation
    Proteolysis Putative SUMO-1 pathway0.33
    3Regulation of Androgen receptor activity
    Regulation of Androgen receptor activity
    4Protein Stability
    Protein Stability

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for SENP1
        Proteolysis Putative SUMO-1 pathway


    1 Cell Signaling Technology (CST) Pathway for SENP1
        Protein Stability

    1 GeneGo (Thomson Reuters) Pathway for SENP1
        Proteolysis Putative SUMO-1 pathway

    1 BioSystems Pathway for SENP1
        Regulation of Androgen receptor activity

    3        Reactome Pathways for SENP1
        SUMOylation
    Processing and Activation of SUMO
    Proteolytic Processing of SUMO



    SENP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SENP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/16 Interacting proteins for SENP1 (Q9P0U32, 3 ENSP000003947914) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO3P558542, 3MINT-8404201 I2D: score=1 
    SUMO1P631652, 3, ENSP000003760764MINT-8404192 MINT-60089 MINT-8402559 I2D: score=1 STRING: ENSP00000376076
    HDAC4P565243, ENSP000002646064I2D: score=1 STRING: ENSP00000264606
    RUVBL2Q9Y2303, ENSP000002214134I2D: score=1 STRING: ENSP00000221413
    HDAC1Q135473, ENSP000003626494I2D: score=2 STRING: ENSP00000362649
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IMP1087798
    GO:0010724regulation of definitive erythrocyte differentiation IEA--
    GO:0016925protein sumoylation TAS--
    GO:0016926protein desumoylation ISS--

    SENP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SENP1

    Search CenterWatch for drugs/clinical trials and news about SENP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SENP1 gene (3 alternative transcripts): 
    NM_001267594.1  NM_001267595.1  NM_014554.2  

    Unigene Cluster for SENP1:

    SUMO1/sentrin specific peptidase 1
    Hs.371957  [show with all ESTs]
    Unigene Representative Sequence: NR_051992
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000552189 ENST00000551330 ENST00000549595 ENST00000549518 ENST00000551358
    ENST00000547886 ENST00000551592 ENST00000551798 ENST00000547181 ENST00000549882
    ENST00000004980(uc009zkx.3) ENST00000448372(uc001rqw.3 uc001rqx.3)
    ENST00000339976(uc001rqy.3 uc001rqz.3)
    miRNA
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SENP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SENP1

    Additional mRNA sequence: 

    AF149770.1 AK292060.1 AK312874.1 BC045639.1 BX537920.1 BX640784.1 NR_051991.1 NR_051992.1 

    14 DOTS entries:

    DT.451936  DT.100749882  DT.97817393  DT.75196800  DT.95227048  DT.121130704  DT.91741544  DT.100647897 
    DT.100736633  DT.100749885  DT.91685926  DT.95154463  DT.95296538  DT.424231 

    24/119 AceView cDNA sequences (see all 119):

    AA742206 BU508271 AA236084 AF149770 AA236014 AA443166 AA459667 CB105391 
    NM_014554 AA330056 BG187745 AI150440 AI660297 BX282471 AA766152 AA863254 
    BX451374 AL582829 BU621740 BF109003 BG184502 BG217863 BG194785 BM722715 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SENP1 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:                    -           -                       -           -                       -                                                               
    SP2:                                                        -           -                       -                                                               
    SP3:        -     -     -           -                       -           -                                                                                       
    SP4:                                -                       -           -                                                                                       
    SP5:                                                        -           -                                                                                       

    ExUns: 21 ^ 22a · 22b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for SENP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SENP1 expression in normal human tissues (normalized intensities)      SENP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAACAAAAGC
    SENP1 Expression
    About this image


    SENP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See SENP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SENP1

    SOURCE GeneReport for Unigene cluster: Hs.371957

    UniProtKB/Swiss-Prot: SENP1_HUMAN, Q9P0U3
    Tissue specificity: Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver,
    ovary and small intestine

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SENP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SENP1 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SENP16
    Uncharacterized protein
    65(a)
    1 ↔ 1
    JH375554.1(45613-61285)
    lizard
    (Anolis carolinensis)
    Reptilia SENP16
    SUMO1/sentrin specific peptidase 1
    68(a)
    1 ↔ 1
    GL343536.1(186090-224631)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985172 SUMO-specific protease U1p1 76.16(n)    AF526893.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.239642 Danio rerio cDNA clone IMAGE2599740, partial cds 76.88(n)    BC054703.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ulp13 protein deubiquitination
    ubiquitin-specific protease
    50(a)
    (best of 2)
      18B1   --
    worm
    (Caenorhabditis elegans)
    Secernentea T10F2.33   -- 38(a)   III(5237838-5241523)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ULP1(YPL020C)4 Protease that specifically cleaves Smt3p protein conjugates; more   --   16(514178-512313) 856087  NP_015305.1 
            Species with no ortholog for SENP1

    ENSEMBL Gene Tree for SENP1 (if available)
    TreeFam Gene Tree for SENP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SENP1 gene
    SENP32  SENP22  SENP52  
    3 SIMAP similar genes for SENP1 using alignment to 3 protein entries:     SENP1_HUMAN (see all proteins):
    DKFZp686L1432    DKFZp686P15142    SENP2

    SENP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1257 SNPs in SENP1 are shown (see all 1257)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs777408841,2
    C--48436188(+) ATGGAC/TAGGCT 4 -- ds50010--------
    rs1439816091,2
    --48436369(+) GTCAAC/TTGACA 4 -- ds50010--------
    rs1505936321,2
    C--48436389(+) CAGACA/TGGATG 4 -- ds50010--------
    rs1395965851,2
    --48436394(+) TGGATA/GAGGGA 4 -- ds50010--------
    rs1497212531,2
    C--48436613(+) CTTATC/TATCCC 4 -- ds50010--------
    rs22860221,2
    C,F,H--48436647(-) ATTCAC/TCTGCC 4 -- ds50019Minor allele frequency- T:0.43EA NS NA CSA WA 2156
    rs740867721,2
    C--48436792(+) ATCAAA/GGCCTA 4 -- ut31 nc-transcript-variant2Minor allele frequency- G:0.13WA 120
    rs608943561,2
    C,F--48437095(+) GGAAGG/TTAAGA 4 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.03WA 118
    rs1413299581,2
    --48437214(+) ATCGAC/TACCAT 4 -- ut31 nc-transcript-variant0--------
    rs1930032141,2
    --48437227(+) TGCCAC/TCTTTC 4 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for SENP1 (48436681 - 48500091 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SENP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832401CNV Loss17160897
    nsv508673CNV Loss20534489
    dgv509e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612157    OMIM disorders: --

    10 diseases for SENP1:    About MalaCards
    teratoma    herpes simplex    hypoxia    colon cancer
    cerebritis    rheumatoid arthritis    arthritis    prostate cancer
    prostatitis    endotheliitis


    SENP1 for disorders           About GeneDecksing


    Export disorders for SENP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SENP1 gene, integrated from 9 sources (see all 59):
    (articles sorted by number of sources associating them with SENP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1. (PubMed id 14563852)1, 2, 3, 9 Bailey D. and O'Hare P. (2004)
    2. Differential regulation of sentrinized proteins by a novel sentrin- specific protease. (PubMed id 10652325)1, 2, 3 Gong L.... Yeh E.T.H. (2000)
    3. SUMO protease SENP1 induces isomerization of the scissile peptide bond. (PubMed id 17099698)1, 2, 9 Shen L....Hay R.T. (2006)
    4. The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing. (PubMed id 16553580)1, 2, 9 Shen L.N.... Hay R.T. (2006)
    5. Crystal structure of the SENP1 mutant C603S-SUMO complex reveals the hydrolytic mechanism of SUMO-specific protease. (PubMed id 16712526)1, 2 Xu Z.... Au S.W.N. (2006)
    6. Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1. (PubMed id 16253240)1, 2 Kim Y.H.... Kim Y. (2005)
    7. Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1. (PubMed id 15487983)1, 2 Xu Z. and Au S.W.N. (2005)
    8. SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1. (PubMed id 15199155)1, 2 Cheng J.... Yeh E.T.H. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. SUMO-specific protease 1 (SENP1) reverses the hormone-augmented SUMOylation of androgen receptor and modulates gene responses in prostate cancer cells. (PubMed id 19116244)1, 9 Kaikkonen S....Palvimo J.J. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29843 HGNC: 17927 AceView: SENP1 Ensembl:ENSG00000079387 euGenes: HUgn29843
    ECgene: SENP1 H-InvDB: SENP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SENP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SENP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SENP1 gene:
    Search GeneIP for patents involving SENP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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