Aliases for SENP1 Gene
External Ids for SENP1 Gene
Previous GeneCards Identifiers for SENP1 Gene
This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
GeneCards Summary for SENP1 Gene
SENP1 (SUMO1/Sentrin Specific Peptidase 1) is a Protein Coding gene. Diseases associated with SENP1 include Chronic Mountain Sickness and Retinitis Pigmentosa 42. Among its related pathways are SUMOylation and Metabolism of proteins. GO annotations related to this gene include cysteine-type peptidase activity and SUMO-specific protease activity. An important paralog of this gene is SENP2.
UniProtKB/Swiss-Prot for SENP1 Gene
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032).