SENP1 Gene
protein-coding GIFtS: 63
GCID: GC12M048436
|
|
SUMO1/sentrin specific peptidase 1(Previous name: SUMO1/sentrin specific protease 1 )
| |
Aliases
for SENP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SUMO1/Sentrin Specific Peptidase 11 2 | | Sentrin-Specific Protease 12 | | SUMO1/Sentrin Specific Protease 11 2 | | EC 3.4.22.683 | | Sentrin/SUMO-Specific Protease SENP12 3 | | EC 3.4.228 | | SuPr-22 | | |
Export aliases for SENP1 gene to outside databasesPrevious GC identifers: GC12M048451 GC12M048338 GC12M048154 GC12M046725 GC12M046722 GC12M045468 |
Summaries
for SENP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SENP1:
This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO)protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease alsofunctions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multipletranscript variants. (provided by RefSeq, Jun 2012)
UniProtKB/Swiss-Prot: SENP1_HUMAN, Q9P0U3Function: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity
Gene Wiki entry for SENP1
|
Genomic Views
for SENP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SENP1 gene promoter:
HOXA9B HOXA9 AP-1 ATF-2 FOXD1 CUTL1 STAT5A Meis-1a c-Jun Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SENP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SENP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.1 Ensembl cytogenetic band: 12q13.11 HGNC cytogenetic band: 12q13.1SENP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M048436: view genomic region
(about GC identifiers)
Start:
|
48,436,681 bp from pter |
End:
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48,500,091 bp from pter |
Size:
|
63,411 bases |
Orientation:
|
minus strand |
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Proteins
for SENP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SENP1_HUMAN, Q9P0U3 (See
protein sequence)Recommended Name: Sentrin-specific protease 1 Size: 644 amino acids; 73481 Da
Subcellular location: Nucleus. Cytoplasm. Note=Shuttles between cytoplasm and nucleus
6/9 PDB 3D structures from  and Proteopedia  for SENP1 (see all 9):2CKG (3D)
2CKH (3D)
2G4D (3D)
2IY0 (3D)
2IY1 (3D)
2IYC (3D)
Secondary accessions: A8K7P5 Q86XC8Alternative splicing: 2 isoforms: Q9P0U3-1 Q9P0U3-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SENP1: NX_Q9P0U3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P0U3
4 DME Specific Peptides for SENP1 (Q9P0U3)
SENP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001254523.1 NP_001254524.1
ENSEMBL proteins: ENSP00000447593 ENSP00000446681 ENSP00000450076 ENSP00000447328 ENSP00000448597 ENSP00000004980 ENSP00000394791 ENSP00000344652
Human Recombinant Protein Products for SENP1:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SENP1 for ontologies About GeneDecksing
SENP1 Antibody Products:
Assay Products for SENP1: |
Protein
Domains /
Families
for SENP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SENP1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9P0U3ProtoNet protein and cluster: Q9P0U3 1 Blocks protein family: IPB003653 SUMO/Sentrin/Ubl1 specific protease
UniProtKB/Swiss-Prot: SENP1_HUMAN, Q9P0U3Similarity: Belongs to the peptidase C48 family |
Function
for SENP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SENP1_HUMAN, Q9P0U3Function: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activityCatalytic activity: Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly- -Ala-Thr-Tyr at the C-terminalend of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A secondreaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO andthe lysine epsilon-amino group of the target protein Enzyme Numbers (IUBMB): EC 3.4.22.681 EC 3.4.222
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
SENP1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for SENP1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SENP1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SENP1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SENP1 (NM_014554) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SENP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SENP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SENP1 |
|
Pathways & Interactions
for SENP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Proteolysis Putative SUMO-1 pathway | | | 2 | Protein Stability | | | 3 | Regulation of Androgen receptor activity | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for SENP1
1 
Cell Signaling Technology (CST) Pathway for SENP1
1  GeneGo (Thomson Reuters) Pathway for SENP1
1  BioSystems Pathway for SENP1
SENP1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SENP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)
5/16 Interacting proteins for SENP1 (Q9P0U32, 3 ENSP000003947914) via UniProtKB, MINT, STRING, and/or I2D (see all 16)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- | | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
IMP | 1087798 | | GO:0010724 | regulation of definitive erythrocyte differentiation |
IEA | -- | | GO:0016926 | protein desumoylation |
ISS | -- | | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
IEA | -- |
SENP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SENP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SENP1
Search CenterWatch for drugs/clinical trials and news about SENP1
|
Transcripts
for SENP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SENP1 gene (3 alternative transcripts): NM_001267594.1 NM_001267595.1 NM_014554.2 Unigene Cluster for SENP1: SUMO1/sentrin specific peptidase 1 Hs.744287 [show with all ESTs]Unigene Representative Sequence: NR_05199213 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000552189 ENST00000551330 ENST00000549595 ENST00000549518 ENST00000551358
ENST00000547886 ENST00000551592 ENST00000551798 ENST00000547181 ENST00000549882
ENST00000004980(uc009zkx.3) ENST00000448372(uc001rqw.3 uc001rqx.3)
ENST00000339976(uc001rqy.3 uc001rqz.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SENP1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SENP1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SENP1 (NM_014554) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SENP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SENP1 |
Additional cDNA sequence: AF149770.1 AK292060.1 AK312874.1 BC045639.1 BX537920.1 BX640784.1 NR_051991.1 NR_051992.1 14 DOTS entries: DT.451936 DT.100749882 DT.97817393 DT.75196800 DT.95227048 DT.121130704 DT.91741544 DT.100647897 DT.100736633 DT.100749885 DT.91685926 DT.95154463 DT.95296538 DT.424231 24/119 AceView cDNA sequences (see all 119): BG187745 AI150440 AF149770 AA863254 NM_014554 AA443166 BX282471 AA459667 AA330056 AA766152 AA236084 BU508271 AA236014 AI660297 AA742206 CB105391 CD359164 BG220848 AA459789 BF515452 BG217863 BX105498 CD243817 BG215768
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SENP1 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ |
|---|
|
| SP1: | | | | | | | - | | | | - | | | | | | | | - | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | - | | - | | | | - | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 21 | ^ | 22a | · | 22b |
|---|
|
| SP1: | | | | | | | |
| SP2: | | | | | | | |
| SP3: | | | | | | | |
| SP4: | | | | | | | |
| SP5: | | | | | | |
ECgene alternative splicing isoforms for SENP1
|
Expression
for SENP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SENP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAACAAAAGC
About this image
See SENP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SENP1
SOURCE GeneReport for Unigene cluster: Hs.744287
UniProtKB/Swiss-Prot: SENP1_HUMAN, Q9P0U3Tissue specificity: Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary andsmall intestine
SABiosciences Custom PCR Arrays for SENP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SENP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SENP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SENP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SENP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SENP1 |
Orthologs
for SENP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SENP1 gene from 8/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SENP16 |
-- |
69(a) |
1 ↔ 1 |
Un(31486592-31499821) |
lizard
(Anolis carolinensis) |
Reptilia |
SENP16 |
-- |
66(a) |
1 ↔ 1 |
GL343536.1(190349-223550) |
African clawed frog
(Xenopus laevis) |
Amphibia |
LOC3985172 |
SUMO-specific protease U1p1 |
76.16(n) |
|
AF526893.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.239642 |
Danio rerio cDNA clone IMAGE2599740, partial cds |
76.88(n) |
|
BC054703.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Ulp13 |
protein deubiquitination ubiquitin-specific
protease |
50(a)
(best of 2) |
|
18B1 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
T10F2.33 |
-- |
38(a) |
|
III(5237838-5241523) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ULP1B6ESD46(see all 3) |
ubiquitin-like-specific protease ESD4(see all 3) |
24(a)23(a)(see all 3) |
many ↔ manymany ↔ many(see all 3) |
4(281313-283129) 4(9012645-9016116) |
rice
(Oryza sativa) |
Liliopsida |
----(see all 3) |
ulp1 protease family protein, putative(see all 3) |
26(a)24(a)(see all 3) |
many ↔ manymany ↔ many(see all 3) |
3(12822303-12826996) 3(16887750-16891075) |
Species with no ortholog for SENP1
ENSEMBL Gene Tree for SENP1 (if available)
TreeFam Gene Tree for SENP1 (if available) |
Paralogs
for SENP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SENP1 gene
- SENP32 SENP22 SENP52
3 SIMAP similar genes for SENP1 using alignment to 3 protein entries: SENP1_HUMAN (see all proteins):DKFZp686L1432 DKFZp686P15142 SENP2
SENP1 for paralogs About GeneDecksing
|
Genomic Variants
for SENP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SENP1 (48436681 - 48500091 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SENP1
1 CNV: 3888 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SENP1 |
|
Disorders
/ Diseases
for SENP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SENP1 for disorders About GeneDecksing
OMIM gene information: 612157
OMIM disorders: --
10  diseases for SENP1: About MalaCardsherpes simplex teratoma rheumatoid arthritis colon cancer
arthritis prostate cancer cerebritis hypoxia
prostatitis malaria
Export disorders for SENP1 gene to outside databases
|
Publications
for SENP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SENP1 gene, integrated from 9 sources (see all 56):
(articles sorted by number of sources associating them with SENP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1. (PubMed id 14563852)1, 2, 3, 9 Bailey D. and O'Hare P. (2004)
- Differential regulation of sentrinized proteins by a novel sentrin- specific protease. (PubMed id 10652325)1, 2, 3 Gong L.... Yeh E.T.H. (2000)
- SUMO protease SENP1 induces isomerization of the scissile peptide bond. (PubMed id 17099698)1, 2, 9 Shen L....Hay R.T. (2006)
- The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing. (PubMed id 16553580)1, 2, 9 Shen L.N.... Hay R.T. (2006)
- Crystal structure of the SENP1 mutant C603S-SUMO complex reveals the hydrolytic mechanism of SUMO-specific protease. (PubMed id 16712526)1, 2 Xu Z.... Au S.W.N. (2006)
- Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1. (PubMed id 16253240)1, 2 Kim Y.H.... Kim Y. (2005)
- Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1. (PubMed id 15487983)1, 2 Xu Z. and Au S.W.N. (2005)
- SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1. (PubMed id 15199155)1, 2 Cheng J.... Yeh E.T.H. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- SUMO-specific protease 1 (SENP1) reverses the hormone-augmented SUMOylation of androgen receptor and modulates gene responses in prostate cancer cells. (PubMed id 19116244)1, 9 Kaikkonen S....Palvimo J.J. (2009)
|
External Searches for SENP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SENP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SENP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SENP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for SENP1 gene:
Search GeneIP for patents involving SENP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SENP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | OriGene Antibodies for SENP1 | | OriGene shRNA RFP for SENP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SENP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SENP1 | | | OriGene Protein Over-expression Lysate for SENP1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SENP1 | | OriGene 3'-UTR Clone for SENP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SENP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SENP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SENP1 | | OriGene Custom Protein Services for SENP1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SENP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SENP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SENP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SENP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SENP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SENP1 |
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| | Antibodies & Assays for SENP1 |
| | | | Search Tocris compounds for SENP1 |
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 | | | SENP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SENP1 |
|  |  |  |  | | | | ThermoFisher Antibodies for SENP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SENP1 |
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