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Aliases for SENP1 Gene

Aliases for SENP1 Gene

  • SUMO1/Sentrin Specific Peptidase 1 2 3
  • Sentrin/SUMO-Specific Protease SENP1 3 4
  • SUMO1/Sentrin Specific Protease 1 2 3
  • EC 3.4.22.68 4
  • EC 3.4.22 63
  • SuPr-2 3

External Ids for SENP1 Gene

Previous GeneCards Identifiers for SENP1 Gene

  • GC12M048451
  • GC12M048338
  • GC12M048154
  • GC12M046725
  • GC12M046722
  • GC12M048436
  • GC12M045468

Summaries for SENP1 Gene

Entrez Gene Summary for SENP1 Gene

  • This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

GeneCards Summary for SENP1 Gene

SENP1 (SUMO1/Sentrin Specific Peptidase 1) is a Protein Coding gene. Diseases associated with SENP1 include chronic mountain sickness. Among its related pathways are Transport to the Golgi and subsequent modification and Regulation of Androgen receptor activity. GO annotations related to this gene include cysteine-type peptidase activity and SUMO-specific protease activity. An important paralog of this gene is SENP5.

UniProtKB/Swiss-Prot for SENP1 Gene

  • Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032).

Gene Wiki entry for SENP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SENP1 Gene

Genomics for SENP1 Gene

Regulatory Elements for SENP1 Gene

Genomic Location for SENP1 Gene

Chromosome:
12
Start:
48,042,898 bp from pter
End:
48,106,308 bp from pter
Size:
63,411 bases
Orientation:
Minus strand

Genomic View for SENP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SENP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SENP1 Gene

Proteins for SENP1 Gene

  • Protein details for SENP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0U3-SENP1_HUMAN
    Recommended name:
    Sentrin-specific protease 1
    Protein Accession:
    Q9P0U3
    Secondary Accessions:
    • A8K7P5
    • Q86XC8

    Protein attributes for SENP1 Gene

    Size:
    644 amino acids
    Molecular mass:
    73481 Da
    Quaternary structure:
    • Interacts with MTA1. Interacts with CCAR2 (via N-terminus).

    Three dimensional structures from OCA and Proteopedia for SENP1 Gene

    Alternative splice isoforms for SENP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SENP1 Gene

Proteomics data for SENP1 Gene at MOPED

Selected DME Specific Peptides for SENP1 Gene

Post-translational modifications for SENP1 Gene

  • Ubiquitination at Lys 111 and Lys 577
  • Modification sites at PhosphoSitePlus

Other Protein References for SENP1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SENP1 (SENP1)

Domains & Families for SENP1 Gene

Gene Families for SENP1 Gene

Protein Domains for SENP1 Gene

Suggested Antigen Peptide Sequences for SENP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P0U3

UniProtKB/Swiss-Prot:

SENP1_HUMAN :
  • Belongs to the peptidase C48 family.
Family:
  • Belongs to the peptidase C48 family.
genes like me logo Genes that share domains with SENP1: view

Function for SENP1 Gene

Molecular function for SENP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly- -Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein
UniProtKB/Swiss-Prot Function:
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032).

Enzyme Numbers (IUBMB) for SENP1 Gene

Gene Ontology (GO) - Molecular Function for SENP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity TAS 10652325
GO:0005515 protein binding IPI 21965678
GO:0008234 cysteine-type peptidase activity --
GO:0016929 SUMO-specific protease activity ISS --
genes like me logo Genes that share ontologies with SENP1: view

Phenotypes for SENP1 Gene

genes like me logo Genes that share phenotypes with SENP1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SENP1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for SENP1 Gene

Localization for SENP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SENP1 Gene

Nucleus. Cytoplasm. Note=Shuttles between cytoplasm and nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SENP1 Gene COMPARTMENTS Subcellular localization image for SENP1 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for SENP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005925 focal adhesion IDA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with SENP1: view

Pathways & Interactions for SENP1 Gene

genes like me logo Genes that share pathways with SENP1: view

Pathways by source for SENP1 Gene

SIGNOR curated interactions for SENP1 Gene

Activates:

Gene Ontology (GO) - Biological Process for SENP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis TAS 10652325
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IMP 1087798
GO:0010724 regulation of definitive erythrocyte differentiation IEA --
GO:0016925 protein sumoylation TAS --
GO:0016926 protein desumoylation IMP 21965678
genes like me logo Genes that share ontologies with SENP1: view

Drugs & Compounds for SENP1 Gene

No Compound Related Data Available

Transcripts for SENP1 Gene

Unigene Clusters for SENP1 Gene

SUMO1/sentrin specific peptidase 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SENP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SENP1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - -
SP5: - -
SP6: - -
SP7: -
SP8: - -

ExUns: 21 ^ 22a · 22b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for SENP1 Gene

GeneLoc Exon Structure for
SENP1
ECgene alternative splicing isoforms for
SENP1

Expression for SENP1 Gene

mRNA expression in normal human tissues for SENP1 Gene

mRNA differential expression in normal tissues according to GTEx for SENP1 Gene

This gene is overexpressed in Testis (x5.6).

Protein differential expression in normal tissues from HIPED for SENP1 Gene

This gene is overexpressed in Breast (47.1) and Placenta (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SENP1 Gene



SOURCE GeneReport for Unigene cluster for SENP1 Gene Hs.371957

mRNA Expression by UniProt/SwissProt for SENP1 Gene

Q9P0U3-SENP1_HUMAN
Tissue specificity: Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine.
genes like me logo Genes that share expression patterns with SENP1: view

Protein tissue co-expression partners for SENP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SENP1 Gene

Orthologs for SENP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SENP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SENP1 36
  • 99 (a)
OneToOne
SENP1 35
  • 99.69 (n)
  • 99.22 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia SENP1 36
  • 49 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Senp1 36
  • 89 (a)
OneToOne
Senp1 35
  • 86.51 (n)
  • 88.75 (a)
oppossum
(Monodelphis domestica)
Mammalia SENP1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SENP1 36
  • 93 (a)
OneToOne
SENP1 35
  • 93.37 (n)
  • 93.48 (a)
cow
(Bos Taurus)
Mammalia SENP1 36
  • 91 (a)
OneToOne
SENP1 35
  • 92.18 (n)
  • 91.93 (a)
rat
(Rattus norvegicus)
Mammalia Senp1 35
  • 86.25 (n)
  • 88.91 (a)
chicken
(Gallus gallus)
Aves SENP1 36
  • 65 (a)
OneToOne
SENP1 35
  • 69.48 (n)
  • 72.77 (a)
lizard
(Anolis carolinensis)
Reptilia SENP1 36
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398517 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20119 35
senp1 35
  • 63.61 (n)
  • 61.22 (a)
zebrafish
(Danio rerio)
Actinopterygii SENP1 36
  • 41 (a)
OneToOne
si:dkey-21c19.3 35
  • 58.43 (n)
  • 56.86 (a)
Dr.23964 35
fruit fly
(Drosophila melanogaster)
Insecta Ulp1 36
  • 11 (a)
ManyToMany
CG32110 36
  • 27 (a)
ManyToMany
CG11023 36
  • 27 (a)
ManyToMany
Ulp1 37
  • 50 (a)
CG11023 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea T10F2.3 37
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ULP1 36
  • 18 (a)
OneToMany
Species with no ortholog for SENP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SENP1 Gene

ENSEMBL:
Gene Tree for SENP1 (if available)
TreeFam:
Gene Tree for SENP1 (if available)

Paralogs for SENP1 Gene

Paralogs for SENP1 Gene

(3) SIMAP similar genes for SENP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SENP1: view

Variants for SENP1 Gene

Sequence variations from dbSNP and Humsavar for SENP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1775 -- 48,058,721(+) AGGTA(G/T)GAAAA intron-variant
rs3997 -- 48,087,804(+) CACCA(C/T)AAAGC intron-variant
rs767420 -- 48,051,068(-) CTTAC(A/G)ATTCC intron-variant
rs886588 -- 48,083,639(-) AGTCT(C/T)TTGAG synonymous-codon, reference, nc-transcript-variant, utr-variant-5-prime
rs886589 -- 48,083,414(-) AAGAG(A/G)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SENP1 Gene

Variant ID Type Subtype PubMed ID
nsv832401 CNV Loss 17160897
dgv509e1 CNV Complex 17122850
nsv508673 CNV Loss 20534489

Variation tolerance for SENP1 Gene

Residual Variation Intolerance Score: 13.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SENP1 Gene

HapMap Linkage Disequilibrium report
SENP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SENP1 Gene

Disorders for SENP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SENP1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
chronic mountain sickness
- elite association
Search SENP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SENP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SENP1
genes like me logo Genes that share disorders with SENP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SENP1 Gene

Publications for SENP1 Gene

  1. Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1. (PMID: 14563852) Bailey D. … O'Hare P. (J. Biol. Chem. 2004) 2 23 67
  2. SUMO-specific protease 1 (SENP1) reverses the hormone-augmented SUMOylation of androgen receptor and modulates gene responses in prostate cancer cells. (PMID: 19116244) Kaikkonen S. … Palvimo J.J. (Mol. Endocrinol. 2009) 23 67
  3. The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction. (PMID: 18474224) Ohbayashi N. … Matsuda T. (Biochem. Biophys. Res. Commun. 2008) 23 67
  4. Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts. (PMID: 18616636) Yates K.E. … DiMaio D. (Aging Cell 2008) 23 67
  5. Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cells. (PMID: 17932034) Bawa-Khalfe T. … Yeh E.T. (J. Biol. Chem. 2007) 23 67

Products for SENP1 Gene

Sources for SENP1 Gene

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