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SENP1 Gene

protein-coding   GIFtS: 66
GCID: GC12M048436

SUMO1/Sentrin Specific Peptidase 1

(Previous name: SUMO1/sentrin specific protease 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SUMO1/Sentrin Specific Peptidase 11 2     Sentrin-Specific Protease 12
SUMO1/Sentrin Specific Protease 11 2     EC 3.4.22.683
Sentrin/SUMO-Specific Protease SENP12 3     EC 3.4.228
SuPr-22     

External Ids:    HGNC: 179271   Entrez Gene: 298432   Ensembl: ENSG000000793877   OMIM: 6121575   UniProtKB: Q9P0U33   

Export aliases for SENP1 gene to outside databases

Previous GC identifers: GC12M048451 GC12M048338 GC12M048154 GC12M046725 GC12M046722 GC12M045468


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SENP1 Gene:
This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier
(SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease
also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in
multiple transcript variants. (provided by RefSeq, Jun 2012)

GeneCards Summary for SENP1 Gene:
SENP1 (SUMO1/sentrin specific peptidase 1) is a protein-coding gene. Diseases associated with SENP1 include testicular germ cell tumor, and teratoma. GO annotations related to this gene include endopeptidase activity and SUMO-specific protease activity. An important paralog of this gene is SENP3.

UniProtKB/Swiss-Prot: SENP1_HUMAN, Q9P0U3
Function: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1,
SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins.
Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression
activity

Gene Wiki entry for SENP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SENP1 gene promoter:
         HOXA9B   HOXA9   AP-1   ATF-2   FOXD1   CUTL1   STAT5A   Meis-1a   c-Jun   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSENP1 promoter sequence
   Search Chromatin IP Primers for SENP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SENP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.1   Ensembl cytogenetic band:  12q13.11   HGNC cytogenetic band: 12q13.1

SENP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SENP1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M048436:  view genomic region     (about GC identifiers)

Start:
48,436,681 bp from pter      End:
48,500,091 bp from pter
Size:
63,411 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SENP1_HUMAN, Q9P0U3 (See protein sequence)
Recommended Name: Sentrin-specific protease 1  
Size: 644 amino acids; 73481 Da
Selected PDB 3D structures from and Proteopedia for SENP1 (see all 9):
2CKG (3D)        2CKH (3D)        2G4D (3D)        2IY0 (3D)        2IY1 (3D)        2IYC (3D)    
Secondary accessions: A8K7P5 Q86XC8
Alternative splicing: 2 isoforms:  Q9P0U3-1   Q9P0U3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SENP1: NX_Q9P0U3

Explore proteomics data for SENP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys111, Lys577
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for SENP1 (Q9P0U3)
     MVWEILH  NGSDCGMF  GYQAVKRWTK  WLNDEIINFY 


    See SENP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001254523.1  NP_001254524.1  

    ENSEMBL proteins: 
     ENSP00000447593   ENSP00000446681   ENSP00000450076   ENSP00000447328   ENSP00000448597  
     ENSP00000004980   ENSP00000394791   ENSP00000344652  
    Reactome Protein details: Q9P0U3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003653 Peptidase_C48

    Graphical View of Domain Structure for InterPro Entry Q9P0U3

    ProtoNet protein and cluster: Q9P0U3

    1 Blocks protein domain: IPB003653 SUMO/Sentrin/Ubl1 specific protease

    UniProtKB/Swiss-Prot: SENP1_HUMAN, Q9P0U3
    Similarity: Belongs to the peptidase C48 family


    SENP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SENP1_HUMAN, Q9P0U3
    Function: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1,
    SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins.
    Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression
    activity
    Catalytic activity: Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly- -Ala-Thr-Tyr at the
    C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the
    protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine
    of the mature SUMO and the lysine epsilon-amino group of the target protein

         Enzyme Numbers (IUBMB): EC 3.4.22.681 EC 3.4.222

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004175endopeptidase activity TAS10652325
    GO:0005515protein binding IPI--
    GO:0008234cysteine-type peptidase activity ----
    GO:0016929SUMO-specific protease activity ISS--
         
    SENP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SENP1:
     Decreased viability of wild-ty 

    Animal Models:
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    miRTarBase miRNAs that target SENP1:
    hsa-mir-34a-5p (MIRT025428), hsa-mir-133a-3p (MIRT021701), hsa-mir-18a-3p (MIRT040813), hsa-mir-375 (MIRT019847), hsa-mir-193b-3p (MIRT016404), hsa-mir-192-5p (MIRT026415), hsa-mir-183-5p (MIRT025028)

    Block miRNA regulation of human, mouse, rat SENP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SENP1 (see all 101):
    hsa-miR-579 hsa-miR-576-3p hsa-miR-520e hsa-miR-520f hsa-miR-607 hsa-miR-4254 hsa-miR-188-5p hsa-miR-485-3p
    SwitchGear 3'UTR luciferase reporter plasmidSENP1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SENP1_HUMAN, Q9P0U3: Nucleus. Cytoplasm. Note=Shuttles between cytoplasm and nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--
    GO:0005925focal adhesion IDA--
    GO:0031965nuclear membrane IDA--

    SENP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SENP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Processing and Activation of SUMO
    Processing and Activation of SUMO
    Proteolytic Processing of SUMO0.00
    SUMOylation0.00
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30
    3Proteolysis Putative SUMO 1 pathway
    Proteolysis Putative SUMO 1 pathway0.33
    4Regulation of Androgen receptor activity
    Regulation of Androgen receptor activity
    5Protein Stability
    Protein Stability

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SENP1
        Protein Stability

    1 GeneGo (Thomson Reuters) Pathway for SENP1
        Proteolysis Putative SUMO-1 pathway

    1 BioSystems Pathway for SENP1
        Regulation of Androgen receptor activity

    1 Reactome Pathway for SENP1
        SUMO is proteolytically processed



    SENP1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SENP1
    Interactions:

        GeneGlobe Interaction Network for SENP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SENP1 (Q9P0U31, 2, 3 ENSP000003947914) via UniProtKB, MINT, STRING, and/or I2D (see all 99)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO3P558542, 3MINT-8404201 I2D: score=1 
    SUMO1P631651, 2, 3, ENSP000003760764EBI-2822935,EBI-80140 MINT-8404192 MINT-60089 MINT-8402559 I2D: score=1 STRING: ENSP00000376076
    HDAC4P565243, ENSP000002646064I2D: score=1 STRING: ENSP00000264606
    RUVBL2Q9Y2303, ENSP000002214134I2D: score=1 STRING: ENSP00000221413
    HDAC1Q135473, ENSP000003626494I2D: score=2 STRING: ENSP00000362649
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS10652325
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IMP1087798
    GO:0010724regulation of definitive erythrocyte differentiation IEA--
    GO:0016925protein sumoylation TAS--
    GO:0016926protein desumoylation ISS--

    SENP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SENP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SENP1 gene (3 alternative transcripts): 
    NM_001267594.1  NM_001267595.1  NM_014554.2  

    Unigene Cluster for SENP1:

    SUMO1/sentrin specific peptidase 1
    Hs.371957  [show with all ESTs]
    Unigene Representative Sequence: NR_051992
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000552189 ENST00000551330 ENST00000549595 ENST00000549518 ENST00000551358
    ENST00000547886 ENST00000551592 ENST00000551798 ENST00000547181 ENST00000549882
    ENST00000004980(uc009zkx.3) ENST00000448372(uc001rqw.3 uc001rqx.3)
    ENST00000339976(uc001rqy.3 uc001rqz.3)
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    hsa-miR-579 hsa-miR-576-3p hsa-miR-520e hsa-miR-520f hsa-miR-607 hsa-miR-4254 hsa-miR-188-5p hsa-miR-485-3p
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      QuantiTect SYBR Green Assays in human, mouse, rat SENP1
      QuantiFast Probe-based Assays in human, mouse, rat SENP1

    Additional mRNA sequence: 

    AF149770.1 AK292060.1 AK312874.1 BC045639.1 BX537920.1 BX640784.1 NR_051991.1 NR_051992.1 

    14 DOTS entries:

    DT.451936  DT.100749882  DT.97817393  DT.75196800  DT.95227048  DT.121130704  DT.91741544  DT.100647897 
    DT.100736633  DT.100749885  DT.91685926  DT.95154463  DT.95296538  DT.424231 

    Selected AceView cDNA sequences (see all 119):

    AA459667 AI660297 AA766152 AA236084 BG187745 AA443166 NM_014554 CB105391 
    BU508271 AI150440 BX282471 AF149770 AA236014 AA330056 AA863254 AA742206 
    AA876229 AL705666 BM722715 BM679201 AI026695 CD359164 AA905329 AL121457 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SENP1 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:                    -           -                       -           -                       -                                                               
    SP2:                                                        -           -                       -                                                               
    SP3:        -     -     -           -                       -           -                                                                                       
    SP4:                                -                       -           -                                                                                       
    SP5:                                                        -           -                                                                                       

    ExUns: 21 ^ 22a · 22b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for SENP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SENP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAACAAAAGC
    SENP1 Expression
    About this image


    SENP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    SENP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SENP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.371957

    UniProtKB/Swiss-Prot: SENP1_HUMAN, Q9P0U3
    Tissue specificity: Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver,
    ovary and small intestine

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SENP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SENP1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Senp11 SUMO1/sentrin specific peptidase 1 86.51(n)
    88.75(a)
      223870  NM_144851.5  NP_659100.1 
    chicken
    (Gallus gallus)
    Aves SENP11 SUMO1/sentrin specific peptidase 1 69.48(n)
    72.77(a)
      426185  XM_423848.4  XP_423848.4 
    lizard
    (Anolis carolinensis)
    Reptilia SENP16
    SUMO1/sentrin specific peptidase 1
    69(a)
    1 ↔ 1
    GL343536.1(186090-224631)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985172 SUMO-specific protease U1p1 76.16(n)    AF526893.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.239642 Danio rerio cDNA clone IMAGE2599740, partial cds 76.88(n)    BC054703.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ulp13 protein deubiquitination
    ubiquitin-specific protease
    50(a)
    (best of 2)
      18B1   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ULP1(YPL020C)4 Protease that specifically cleaves Smt3p protein conjugates; more   --   16(514178-512313) 856087  NP_015305.1 


    ENSEMBL Gene Tree for SENP1 (if available)
    TreeFam Gene Tree for SENP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SENP1 gene
    SENP32  SENP22  SENP52  
    3 SIMAP similar genes for SENP1 using alignment to 3 protein entries:     SENP1_HUMAN (see all proteins):
    DKFZp686L1432    DKFZp686P15142    SENP2

    SENP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SENP1 (see all 1257)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs777408841,2
    C--48436188(+) ATGGAC/TAGGCT 4 -- ds50010--------
    rs1439816091,2
    --48436369(+) GTCAAC/TTGACA 4 -- ds50010--------
    rs1505936321,2
    C--48436389(+) CAGACA/TGGATG 4 -- ds50010--------
    rs1395965851,2
    --48436394(+) TGGATA/GAGGGA 4 -- ds50010--------
    rs1497212531,2
    C--48436613(+) CTTATC/TATCCC 4 -- ds50010--------
    rs22860221,2
    C,F,H--48436647(-) ATTCAC/TCTGCC 4 -- ds50019Minor allele frequency- T:0.43EA NS NA CSA WA 2156
    rs740867721,2
    C--48436792(+) ATCAAA/GGCCTA 4 -- ut31 nc-transcript-variant2Minor allele frequency- G:0.13WA 120
    rs608943561,2
    C,F--48437095(+) GGAAGG/TTAAGA 4 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.03WA 118
    rs1413299581,2
    --48437214(+) ATCGAC/TACCAT 4 -- ut31 nc-transcript-variant0--------
    rs1930032141,2
    --48437227(+) TGCCAC/TCTTTC 4 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for SENP1 (48436681 - 48500091 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SENP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832401CNV Loss17160897
    nsv508673CNV Loss20534489
    dgv509e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SENP1
    DNA2.0 Custom Variant and Variant Library Synthesis for SENP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612157    OMIM disorders: --

    13 diseases for SENP1:    
    About MalaCards
    testicular germ cell tumor    teratoma    germ cell tumors    herpes simplex
    hypoxia    tonsillitis    cerebritis    rheumatoid arthritis
    arthritis    prostate cancer    prostatitis    endotheliitis
    thyroiditis


    SENP1 for disorders           About GeneDecksing


    Export disorders for SENP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SENP1 gene, integrated from 10 sources (see all 60):
    (articles sorted by number of sources associating them with SENP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1. (PubMed id 14563852)1, 2, 3, 9 Bailey D. and O'Hare P. (J. Biol. Chem. 2004)
    2. Differential regulation of sentrinized proteins by a novel sentrin- specific protease. (PubMed id 10652325)1, 2, 3 Gong L.... Yeh E.T.H. (J. Biol. Chem. 2000)
    3. SUMO protease SENP1 induces isomerization of the scissile peptide bond. (PubMed id 17099698)1, 2, 9 Shen L.... Hay R.T. (Nat. Struct. Mol. Biol. 2006)
    4. The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing. (PubMed id 16553580)1, 2, 9 Shen L.N.... Hay R.T. (Biochem. J. 2006)
    5. Crystal structure of the SENP1 mutant C603S-SUMO complex reveals the hydrolytic mechanism of SUMO-specific protease. (PubMed id 16712526)1, 2 Xu Z.... Au S.W.N. (Biochem. J. 2006)
    6. Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1. (PubMed id 16253240)1, 2 Kim Y.H.... Kim Y. (FEBS Lett. 2005)
    7. Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1. (PubMed id 15487983)1, 2 Xu Z. and Au S.W.N. (Biochem. J. 2005)
    8. SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1. (PubMed id 15199155)1, 2 Cheng J.... Yeh E.T.H. (Mol. Cell. Biol. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. SUMO-specific protease 1 (SENP1) reverses the hormone-augmented SUMOylation of androgen receptor and modulates gene responses in prostate cancer cells. (PubMed id 19116244)1, 9 Kaikkonen S....Palvimo J.J. (Mol. Endocrinol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29843 HGNC: 17927 AceView: SENP1 Ensembl:ENSG00000079387 euGenes: HUgn29843
    ECgene: SENP1 H-InvDB: SENP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SENP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SENP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SENP1 gene:
    Search GeneIP for patents involving SENP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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