External Ids for SEMG2 Gene
The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. An antibacterial activity has been found for a antimicrobial peptide isolated from this protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20. [provided by RefSeq, Jan 2015]
GeneCards Summary for SEMG2 Gene
SEMG2 (Semenogelin II) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is SEMG1.
UniProtKB/Swiss-Prot for SEMG2 Gene
Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa