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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEMG2 Gene

protein-coding   GIFtS: 46
GCID: GC20P043849

Semenogelin II

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Semenogelin II1 2 3
Semenogelin 21 2
SGII2 3
semenogelin-22

External Ids:    HGNC: 107431   Entrez Gene: 64072   Ensembl: ENSG000001241577   OMIM: 1821415   UniProtKB: Q023833   

Export aliases for SEMG2 gene to outside databases

Previous GC identifers: GC20P043578 GC20P044488 GC20P044535 GC20P043283 GC20P040591


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEMG2 Gene:
The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated
spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the
spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin
protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20. (provided by
RefSeq, Jul 2008)

GeneCards Summary for SEMG2 Gene: 
SEMG2 (semenogelin II) is a protein-coding gene. Diseases associated with SEMG2 include epididymitis, and prostatitis. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is SEMG1.

UniProtKB/Swiss-Prot: SEMG2_HUMAN, Q02383
Function: Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions
and ejaculated spermatozoa

Gene Wiki entry for SEMG2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEMG2 gene promoter:
         HOXA3   SREBP-1c   HNF-4alpha2   GATA-1   SREBP-1b   E47   HNF-4alpha1   SREBP-1a   FOXO4   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEMG2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SEMG2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12-q13.1   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q12-q13.1

SEMG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMG2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P043849:  view genomic region     (about GC identifiers)

Start:
43,849,941 bp from pter      End:
43,853,099 bp from pter
Size:
3,159 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SEMG2_HUMAN, Q02383 (See protein sequence)
Recommended Name: Semenogelin-2 precursor  
Size: 582 amino acids; 65444 Da
Subunit: Interacts with SERPINA5
Subcellular location: Secreted
Secondary accessions: Q53ZU2 Q6X2M5 Q6X2M6

Explore the universe of human proteins at neXtProt for SEMG2: NX_Q02383

Explore proteomics data for SEMG2 at MOPED 

Post-translational modifications:

  • UniProtKB: Semenogelin-2 is thought to form both the 71 kDa polypeptide and, in its glycosylated form, the 76 kDa polypeptide
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q02383

  • SEMG2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SEMG2 Protein Expression
    REFSEQ proteins: NP_002999.1  
    ENSEMBL proteins: 
     ENSP00000361855  

    Human Recombinant Protein Products for SEMG2: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEMG2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space TAS1517240
    GO:0030141secretory granule IEA--

    SEMG2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR008836 Semenogelin

    Graphical View of Domain Structure for InterPro Entry Q02383

    ProtoNet protein and cluster: Q02383

    1 Blocks protein domain: IPB008836 Semenogelin

    UniProtKB/Swiss-Prot: SEMG2_HUMAN, Q02383
    Similarity: Belongs to the semenogelin family


    SEMG2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEMG2_HUMAN, Q02383
    Function: Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions
    and ejaculated spermatozoa

         Genatlas biochemistry entry for SEMG2:
    major protein of seminal fluid,semenogelin 2 (71 and 76 kDa)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
         
    SEMG2 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SEMG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/10 Interacting proteins for SEMG2 (Q023833 ENSP000003618554) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SEMG1P042793, ENSP000003618674I2D: score=2 STRING: ENSP00000361867
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    PRKAR2AP138613, ENSP000002655634I2D: score=1 STRING: ENSP00000265563
    SERPINA5P051543, ENSP000003332034I2D: score=1 STRING: ENSP00000333203
    TGM1P227353, ENSP000002067654I2D: score=1 STRING: ENSP00000206765
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019953sexual reproduction IEA--

    SEMG2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SEMG2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEMG2

    3 Novoseek inferred chemical compound relationships for SEMG2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dextran sulfate 51.5 1 17253189 (1)
    heparin 29 1 17253189 (1)
    serine 24.9 1 17253189 (1)

    Search CenterWatch for drugs/clinical trials and news about SEMG2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SEMG2 gene: 
    NM_003008.2  

    Unigene Cluster for SEMG2:

    Semenogelin II
    Hs.537218  [show with all ESTs]
    Unigene Representative Sequence: BC070306
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000372769(uc010ggz.3 uc002xnk.3 uc002xnl.3)
    miRNA
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMG2

    Additional mRNA sequence: 

    AK312932.1 BC070306.1 M81652.1 

    8 DOTS entries:

    DT.113433  DT.101979904  DT.95155765  DT.120835979  DT.99999880  DT.91706228  DT.95370278  DT.100781310 

    24/344 AceView cDNA sequences (see all 344):

    AA587817 BE673092 BX103602 AA526711 AI675446 AA548430 AA564052 AA588244 
    AA687843 AA643870 AA662758 AA689473 AA687705 AA603924 AA640146 AA662703 
    AI799949 AA564546 BF437377 AI918907 AA526735 NM_003008 AA564531 AA687874 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEMG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SEMG2 Expression
    About this image


    See SEMG2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEMG2

    SOURCE GeneReport for Unigene cluster: Hs.537218

    UniProtKB/Swiss-Prot: SEMG2_HUMAN, Q02383
    Tissue specificity: Seminal vesicles, and to a much lesser extent, epididymis

        SABiosciences Custom PCR Arrays for SEMG2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and chimp.

    Orthologs for SEMG2 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia Q6Y821_PANTR6
    semenogelin I
    75(a)
    1 ↔ 1
    20(42182777-42202165)


    ENSEMBL Gene Tree for SEMG2 (if available)
    TreeFam Gene Tree for SEMG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEMG2 gene
    SEMG12  
    1 SIMAP similar gene for SEMG2 using alignment to 3 protein entries:     SEMG2_HUMAN (see all proteins):
    SEMG1

    SEMG2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/194 SNPs in SEMG2 are shown (see all 194)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs61040651,2
    C,F,A,H--43848079(+) GAACAC/GAACAG 1 -- us2k118Minor allele frequency- G:0.27NS EA NA WA CSA 965
    rs1455605951,2
    --43848107(+) AGGGAA/TGTGTA 1 -- us2k10--------
    rs1896214731,2
    --43848350(+) ATATAA/GCATTG 1 -- us2k10--------
    rs1473157261,2
    C--43848492(+) GTTGTA/CTTCTC 1 -- us2k10--------
    rs342935451,2
    C,F--43848610(+) GAGATC/TGAGAC 1 -- us2k15Minor allele frequency- T:0.50NA CSA 10
    rs592974231,2
    C,F--43848671(+) TAGCCG/AGGCGT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1819158941,2
    --43848762(+) TGAGCC/TGAGAT 1 -- us2k10--------
    rs1454774071,2
    C--43848786(+) TCCAGC/TCTGGG 1 -- us2k10--------
    rs1998598131,2
    --43848828(+) CAAAC-/AAAAAA 1 -- us2k10--------
    rs81831371,2
    C,F,H--43849039(+) TATTCC/ATCACA 1 -- us2k18Minor allele frequency- A:0.03NS EA NA 870

    HapMap Linkage Disequilibrium report for SEMG2 (43849941 - 43853099 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SEMG2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SEMG2
    DNA2.0 Custom Variant and Variant Library Synthesis for SEMG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 182141    OMIM disorders: --

    3 diseases for SEMG2:    About MalaCards
    epididymitis    prostatitis    prostate cancer


    SEMG2 for disorders           About GeneDecksing


    Export disorders for SEMG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEMG2 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with SEMG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20. (PubMed id 1517240)1, 2, 3 Ulvsbaeck M.... Lundwall A. (1992)
    2. Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II. (PubMed id 8665951)1, 2, 9 Malm J.... Lilja H. (1996)
    3. Semenogelin I and semenogelin II, the major gel-forming proteins in human semen, are substrates for transglutaminase. (PubMed id 9523691)1, 3, 9 Peter A....Malm J. (1998)
    4. Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related protein. (PubMed id 1584792)1, 2, 9 Lundwall A. and Lilja H. (1992)
    5. Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen. (PubMed id 14629036)1, 2, 9 Jensen-Seaman M.I. and Li W.-H. (2003)
    6. Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor. (PubMed id 8665956)1, 2, 9 Kise H.... Suzuki K. (1996)
    7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    8. Isolation and structure determination of two peptides occurring in human seminal plasma. (PubMed id 2757795)1, 2 Schneider K.... Spiteller G. (1989)
    9. Semenogelin I and II, the predominant human seminal plasma proteins, are also expressed in non-genital tissues. (PubMed id 12200457)1, 9 Lundwall A....Malm J. (2002)
    10. Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen. (PubMed id 15563730)1, 9 Jonsson M....Malm J. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6407 HGNC: 10743 AceView: SEMG1andSEMG2 Ensembl:ENSG00000124157 euGenes: HUgn6407
    ECgene: SEMG2 H-InvDB: SEMG2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEMG2 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt062.shtml

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEMG2 gene:
    Search GeneIP for patents involving SEMG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Regulatory tfbs in SEMG2 promoter
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     Proteins for SEMG2
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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