SEMG2 Gene
protein-coding GIFtS: 46
GCID: GC20P043849
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semenogelin II
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Aliases
for SEMG2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Semenogelin II1 2 3 | | SGII1 2 3 | | Semenogelin 22 | | Semenogelin-21 |
Export aliases for SEMG2 gene to outside databasesPrevious GC identifers: GC20P043578 GC20P044488 GC20P044535 GC20P043283 GC20P040591 |
Summaries
for SEMG2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SEMG2:
The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculatedspermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoato move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. The genesencoding these two semenogelin proteins are found in a cluster on chromosome 20. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SEMG2_HUMAN, Q02383Function: Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions andejaculated spermatozoa
Gene Wiki entry for SEMG2
|
Genomic Views
for SEMG2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SEMG2 gene promoter:
HOXA3 SREBP-1c HNF-4alpha2 GATA-1 SREBP-1b E47 HNF-4alpha1 SREBP-1a FOXO4 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SEMG2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMG2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q12-q13.1 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q12-q13.1SEMG2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P043849: view genomic region
(about GC identifiers)
Start:
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43,849,941 bp from pter |
End:
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43,853,099 bp from pter |
Size:
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3,159 bases |
Orientation:
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plus strand |
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Proteins
for SEMG2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SEMG2_HUMAN, Q02383 (See
protein sequence)Recommended Name: Semenogelin-2 precursor Size: 582 amino acids; 65444 Da
Subunit: Interacts with SERPINA5
Subcellular location: Secreted
Secondary accessions: Q53ZU2 Q6X2M5 Q6X2M6Explore the universe of human proteins at neXtProt for SEMG2: NX_Q02383
Post-translational modifications:
Semenogelin-2 is thought to form both the 71 kDa polypeptide and, in its glycosylated form, the 76 kDa polypeptide1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q02383
SEMG2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002999.1
ENSEMBL proteins: ENSP00000361855
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SEMG2 for ontologies About GeneDecksing
SEMG2 Antibody Products:
Assay Products for SEMG2: |
Protein
Domains /
Families
for SEMG2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SEMG2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q02383ProtoNet protein and cluster: Q02383 1 Blocks protein family: IPB008836 Semenogelin
UniProtKB/Swiss-Prot: SEMG2_HUMAN, Q02383Similarity: Belongs to the semenogelin family |
Function
for SEMG2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SEMG2_HUMAN, Q02383Function: Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions andejaculated spermatozoa Genatlas biochemistry entry for SEMG2:major protein of seminal fluid,semenogelin 2 (71 and 76 kDa)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMG2
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OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMG2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005198 | structural molecule activity |
IEA | -- |
SEMG2 for ontologies About GeneDecksing
|
Pathways & Interactions
for SEMG2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SEMG2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/10 Interacting proteins for SEMG2 (Q023833 ENSP000003618554) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0019953 | sexual reproduction |
IEA | -- |
SEMG2 for ontologies About GeneDecksing
|
Drugs & Compounds
for SEMG2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SEMG2 for compounds About GeneDecksing
 Browse Tocris compounds for SEMG2
3 Novoseek chemical compound relationships for SEMG2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| dextran sulfate |
51.5 |
1 |
17253189 (1) |
| heparin |
29 |
1 |
17253189 (1) |
| serine |
24.9 |
1 |
17253189 (1) |
Search CenterWatch for drugs/clinical trials and news about SEMG2
|
Transcripts
for SEMG2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SEMG2 gene: NM_003008.2 Unigene Cluster for SEMG2: Semenogelin II Hs.537218 [show with all ESTs]Unigene Representative Sequence: BC0703061 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000372769(uc010ggz.3 uc002xnk.3 uc002xnl.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMG2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMG2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SEMG2 (NM_003008) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SEMG2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMG2 |
Additional cDNA sequence: AK312932.1 BC070306.1 M81652.1 8 DOTS entries: DT.113433 DT.101979904 DT.95155765 DT.120835979 DT.99999880 DT.91706228 DT.95370278 DT.100781310 24/344 AceView cDNA sequences (see all 344): BC056675 AA564052 BE673147 BF437255 BE673092 AA526735 AA526711 BX101120 AA662758 AA643870 AA542943 AA687874 AA542902 AI675446 AA603044 AI936162 AA564176 BC011442 AA588244 J04440 AI826511 AI918907 AA627898 AA640146
GeneLoc Exon Structure
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Expression
for SEMG2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SEMG2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SEMG2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEMG2
SOURCE GeneReport for Unigene cluster: Hs.537218
UniProtKB/Swiss-Prot: SEMG2_HUMAN, Q02383Tissue specificity: Seminal vesicles, and to a much lesser extent, epididymis
SABiosciences Custom PCR Arrays for SEMG2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEMG2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SEMG2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMG2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMG2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMG2 |
Orthologs
for SEMG2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for SEMG2 (if available)
TreeFam Gene Tree for SEMG2 (if available) |
Paralogs
for SEMG2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SEMG2 gene
- SEMG12
1 SIMAP similar gene for SEMG2 using alignment to 3 protein entries: SEMG2_HUMAN (see all proteins):SEMG1
SEMG2 for paralogs About GeneDecksing
|
Genomic Variants
for SEMG2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SEMG2 (43849941 - 43853099 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SEMG2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEMG2 |
|
Disorders
/ Diseases
for SEMG2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SEMG2 for disorders About GeneDecksing
OMIM gene information: 182141
OMIM disorders: --
5  diseases for SEMG2: About MalaCardsprostatitis epididymitis lung carcinoma prostate cancer
carcinoma
Export disorders for SEMG2 gene to outside databases
|
Publications
for SEMG2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SEMG2 gene, integrated from 9 sources (see all 46):
(articles sorted by number of sources associating them with SEMG2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20. (PubMed id 1517240)1, 2, 3 Ulvsbaeck M.... Lundwall A. (1992)
- Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II. (PubMed id 8665951)1, 2, 9 Malm J.... Lilja H. (1996)
- Semenogelin I and semenogelin II, the major gel-forming proteins in human semen, are substrates for transglutaminase. (PubMed id 9523691)1, 3, 9 Peter A....Malm J. (1998)
- Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related protein. (PubMed id 1584792)1, 2, 9 Lundwall A. and Lilja H. (1992)
- Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen. (PubMed id 14629036)1, 2, 9 Jensen-Seaman M.I. and Li W.-H. (2003)
- Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor. (PubMed id 8665956)1, 2, 9 Kise H.... Suzuki K. (1996)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Isolation and structure determination of two peptides occurring in human seminal plasma. (PubMed id 2757795)1, 2 Schneider K.... Spiteller G. (1989)
- Semenogelin I and II, the predominant human seminal plasma proteins, are also expressed in non-genital tissues. (PubMed id 12200457)1, 9 Lundwall A....Malm J. (2002)
- Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen. (PubMed id 15563730)1, 9 Jonsson M....Malm J. (2005)
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External Searches for SEMG2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SEMG2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SEMG2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SEMG2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SEMG2 | Pharmacogenomics, SNPs, Pathways | | Protein Spotlight | http://web.expasy.org/spotlight/back_issues/sptlt062.shtml |
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About This Section
| Patent Information for SEMG2 gene:
Search GeneIP for patents involving SEMG2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SEMG2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SEMG2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEMG2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMG2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMG2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMG2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMG2 |
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 | | | SEMG2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMG2 |
|  |  |  | | | | Search ThermoFisher Antibodies for SEMG2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMG2 |
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