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SEMG2 Gene

protein-coding   GIFtS: 49
GCID: GC20P043849

Semenogelin II

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Semenogelin II1 2 3
Semenogelin 21 2
SGII2 3
semenogelin-22

External Ids:    HGNC: 107431   Entrez Gene: 64072   Ensembl: ENSG000001241577   OMIM: 1821415   UniProtKB: Q023833   

Export aliases for SEMG2 gene to outside databases

Previous GC identifers: GC20P043578 GC20P044488 GC20P044535 GC20P043283 GC20P040591


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SEMG2 Gene:
The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated
spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the
spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin
protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20. (provided by
RefSeq, Jul 2008)

GeneCards Summary for SEMG2 Gene:
SEMG2 (semenogelin II) is a protein-coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is SEMG1.

UniProtKB/Swiss-Prot: SEMG2_HUMAN, Q02383
Function: Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions
and ejaculated spermatozoa

Gene Wiki entry for SEMG2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEMG2 gene promoter:
         HOXA3   SREBP-1c   HNF-4alpha2   GATA-1   SREBP-1b   E47   HNF-4alpha1   SREBP-1a   FOXO4   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEMG2 promoter sequence
   Search Chromatin IP Primers for SEMG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEMG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12-q13.1   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q12-q13.1

SEMG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMG2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P043849:  view genomic region     (about GC identifiers)

Start:
43,849,941 bp from pter      End:
43,853,099 bp from pter
Size:
3,159 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SEMG2_HUMAN, Q02383 (See protein sequence)
Recommended Name: Semenogelin-2 precursor  
Size: 582 amino acids; 65444 Da
Subunit: Interacts with SERPINA5
Secondary accessions: Q53ZU2 Q6X2M5 Q6X2M6

Explore the universe of human proteins at neXtProt for SEMG2: NX_Q02383

Explore proteomics data for SEMG2 at MOPED

Post-translational modifications: 

  • Semenogelin-2 is thought to form both the 71 kDa polypeptide and, in its glycosylated form, the 76 kDa polypeptide1
  • Glycosylation2 at Asn272
  • Modification sites at PhosphoSitePlus

  • See SEMG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002999.1  
    ENSEMBL proteins: 
     ENSP00000361855  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008836 Semenogelin

    Graphical View of Domain Structure for InterPro Entry Q02383

    ProtoNet protein and cluster: Q02383

    1 Blocks protein domain: IPB008836 Semenogelin

    UniProtKB/Swiss-Prot: SEMG2_HUMAN, Q02383
    Similarity: Belongs to the semenogelin family


    Find genes that share domains with SEMG2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEMG2_HUMAN, Q02383
    Function: Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions
    and ejaculated spermatozoa

         Genatlas biochemistry entry for SEMG2:
    major protein of seminal fluid,semenogelin 2 (71 and 76 kDa)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
         
    Find genes that share ontologies with SEMG2           About GenesLikeMe


    Animal Models:
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    hsa-let-7b-5p (MIRT032201), hsa-mir-1 (MIRT023589)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SEMG2_HUMAN, Q02383: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    endoplasmic reticulum1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space TAS1517240
    GO:0030141secretory granule IEA--

    Find genes that share ontologies with SEMG2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEMG2
    Interactions:

        GeneGlobe Interaction Network for SEMG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for SEMG2 (Q023833 ENSP000003618554) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SEMG1P042793, ENSP000003618674I2D: score=2 STRING: ENSP00000361867
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    PRKAR2AP138613, ENSP000002655634I2D: score=1 STRING: ENSP00000265563
    SERPINA5P051543, ENSP000003332034I2D: score=1 STRING: ENSP00000333203
    TGM1P227353, ENSP000002067654I2D: score=1 STRING: ENSP00000206765
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019953sexual reproduction IEA--

    Find genes that share ontologies with SEMG2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEMG2

    3 Novoseek inferred chemical compound relationships for SEMG2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dextran sulfate 51.5 1 17253189 (1)
    heparin 29 1 17253189 (1)
    serine 24.9 1 17253189 (1)



    Find genes that share compounds with SEMG2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SEMG2 gene: 
    NM_003008.2  

    Unigene Cluster for SEMG2:

    Semenogelin II
    Hs.537218  [show with all ESTs]
    Unigene Representative Sequence: BC070306
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000372769(uc010ggz.3 uc002xnk.3 uc002xnl.3)
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    Additional mRNA sequence: 

    AK312932.1 BC070306.1 M81652.1 

    8 DOTS entries:

    DT.113433  DT.101979904  DT.95155765  DT.120835979  DT.99999880  DT.91706228  DT.95370278  DT.100781310 

    Selected AceView cDNA sequences (see all 344):

    AI659688 BX103602 AA687843 AI420927 BF436885 AA542943 BF437255 BX101120 
    AA528141 NM_003008 AA627898 AA564531 AA542902 AA526735 AI821476 AA588244 
    AA631140 AA640182 AA662758 J04440 AI936162 BE673147 AI805039 BC011442 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SEMG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SEMG2 Expression
    About this image

    SEMG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEMG2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.537218

    UniProtKB/Swiss-Prot: SEMG2_HUMAN, Q02383
    Tissue specificity: Seminal vesicles, and to a much lesser extent, epididymis

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and chimp.

    Orthologs for SEMG2 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia SEMG21 semenogelin II 98.03(n)
    96.06(a)
      493189  NM_001009138.1  NP_001009138.1 


    ENSEMBL Gene Tree for SEMG2 (if available)
    TreeFam Gene Tree for SEMG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SEMG2 gene
    SEMG12  
    1 SIMAP similar gene for SEMG2 using alignment to 3 protein entries:     SEMG2_HUMAN (see all proteins):
    SEMG1

    Find genes that share paralogs with SEMG2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SEMG2 (see all 194)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs61040651,2
    C,F,A,H--43848079(+) GAACAC/GAACAG 1 -- us2k118Minor allele frequency- G:0.27NS EA NA WA CSA 965
    rs1455605951,2
    --43848107(+) AGGGAA/TGTGTA 1 -- us2k10--------
    rs1896214731,2
    --43848350(+) ATATAA/GCATTG 1 -- us2k10--------
    rs1473157261,2
    C--43848492(+) GTTGTA/CTTCTC 1 -- us2k10--------
    rs342935451,2
    C,F--43848610(+) GAGATC/TGAGAC 1 -- us2k15Minor allele frequency- T:0.50NA CSA 10
    rs592974231,2
    C,F--43848671(+) TAGCCG/AGGCGT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1819158941,2
    --43848762(+) TGAGCC/TGAGAT 1 -- us2k10--------
    rs1454774071,2
    C--43848786(+) TCCAGC/TCTGGG 1 -- us2k10--------
    rs1998598131,2
    --43848828(+) CAAAC-/AAAAAA 1 -- us2k10--------
    rs81831371,2
    C,F,H--43849039(+) TATTCC/ATCACA 1 -- us2k18Minor allele frequency- A:0.03NS EA NA 870

    HapMap Linkage Disequilibrium report for SEMG2 (43849941 - 43853099 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SEMG2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEMG2
    DNA2.0 Custom Variant and Variant Library Synthesis for SEMG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 182141    OMIM disorders: --


    Find genes that share disorders with SEMG2           About GenesLikeMe


    Export disorders for SEMG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SEMG2 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with SEMG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20. (PubMed id 1517240)1, 2, 3 Ulvsbaeck M.... Lundwall A. (J. Biol. Chem. 1992)
    2. Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II. (PubMed id 8665951)1, 2, 9 Malm J.... Lilja H. (Eur. J. Biochem. 1996)
    3. Semenogelin I and semenogelin II, the major gel-forming proteins in human semen, are substrates for transglutaminase. (PubMed id 9523691)1, 3, 9 Peter A....Malm J. (Eur. J. Biochem. 1998)
    4. Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related protein. (PubMed id 1584792)1, 2, 9 Lundwall A. and Lilja H. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    5. Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen. (PubMed id 14629036)1, 2, 9 Jensen-Seaman M.I. and Li W.-H. (J. Mol. Evol. 2003)
    6. Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor. (PubMed id 8665956)1, 2, 9 Kise H.... Suzuki K. (Eur. J. Biochem. 1996)
    7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    8. Isolation and structure determination of two peptides occurring in human seminal plasma. (PubMed id 2757795)1, 2 Schneider K.... Spiteller G. (Biol. Chem. Hoppe-Seyler 1989)
    9. Semenogelin I and II, the predominant human seminal plasma proteins, are also expressed in non-genital tissues. (PubMed id 12200457)1, 9 Lundwall A....Malm J. (Mol. Hum. Reprod. 2002)
    10. Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen. (PubMed id 15563730)1, 9 Jonsson M....Malm J. (Biochem. J. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6407 HGNC: 10743 AceView: SEMG1andSEMG2 Ensembl:ENSG00000124157 euGenes: HUgn6407
    ECgene: SEMG2 H-InvDB: SEMG2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SEMG2 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/062

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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