Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SEMG1 Gene

protein-coding   GIFtS: 57
GCID: GC20P043835

Semenogelin I


(Previous symbol: SEMG)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Semenogelin I1 2 3     SGI2 3
SEMG1 2 3 5     CT1032
Cancer/Testis Antigen 1031 2     dJ172H20.22
Semen Coagulating Protein1 2     semenogelin-12

External Ids:    HGNC: 107421   Entrez Gene: 64062   Ensembl: ENSG000001242337   OMIM: 1821405   UniProtKB: P042793   

Export aliases for SEMG1 gene to outside databases

Previous GC identifers: GC20P043564 GC20P044474 GC20P044521 GC20P043269 GC20P040577


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SEMG1 Gene:
The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in
the formation of a gel matrix that encases ejaculated spermatozoa. The prostate-specific antigen (PSA) protease
processes this protein into smaller peptides, with each possibly having a separate function. The proteolysis
process breaks down the gel matrix and allows the spermatozoa to move more freely. (provided by RefSeq, Jul 2009)

GeneCards Summary for SEMG1 Gene:
SEMG1 (semenogelin I) is a protein-coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is SEMG2.

UniProtKB/Swiss-Prot: SEMG1_HUMAN, P04279
Function: Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory
gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins
may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by
KLK3/PSA
Function: Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit
the secretion of pituitary follicle-stimulating hormone

Gene Wiki entry for SEMG1 (Semenogelin I) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEMG1 gene promoter:
         HOXA3   SREBP-1a   SREBP-1c   IRF-1   Cdc5   SREBP-1b   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEMG1 promoter sequence
   Search Chromatin IP Primers for SEMG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEMG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12-q13.2   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q12-q13.2

SEMG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMG1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P043835:  view genomic region     (about GC identifiers)

Start:
43,835,638 bp from pter      End:
43,838,414 bp from pter
Size:
2,777 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SEMG1_HUMAN, P04279 (See protein sequence)
Recommended Name: Semenogelin-1 precursor  
Size: 462 amino acids; 52131 Da
Subunit: Occurs in disulfide-linked complexes which may also contain two less abundant 71- and 76-kDa
semenogelin-related polypeptides. Interacts with EPPIN (via C-terminus); Cys-239 is a critical amino acid for
both binding to EPPIN
Secondary accessions: Q53ZV0 Q53ZV1 Q53ZV2 Q6X4I9 Q6Y809 Q6Y822 Q6Y823 Q86U64 Q96QM3
Alternative splicing: 2 isoforms:  P04279-1   P04279-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEMG1: NX_P04279

Explore proteomics data for SEMG1 at MOPED

Post-translational modifications: 

  • Transglutaminase substrate1
  • Rapidly cleaved after ejaculation by KLK3/PSA, resulting in liquefaction of the semen coagulum and the progressive
    release of motile spermatozoa1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SEMG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002998.1  
    ENSEMBL proteins: 
     ENSP00000361867   ENSP00000244069  
    Reactome Protein details: P04279

    SEMG1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SEMG1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SEMG1
    GenScript Custom Purified and Recombinant Proteins Services for SEMG1
    Novus Biologicals SEMG1 Proteins
    Novus Biologicals SEMG1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SEMG1
    Cloud-Clone Corp. Proteins for SEMG1

     
    Search eBioscience for Proteins for SEMG1 

     
    antibodies-online proteins for SEMG1 (6 products) 

     
    antibodies-online peptides for SEMG1

    SEMG1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SEMG1
    Novus Biologicals SEMG1 Antibodies
    Abcam antibodies for SEMG1
    Cloud-Clone Corp. Antibodies for SEMG1
    ThermoFisher Antibodies for SEMG1
    antibodies-online antibodies for SEMG1 (26 products) 

    SEMG1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SEMG1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SEMG1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SEMG1
    Cloud-Clone Corp. CLIAs for SEMG1
    Search eBioscience for ELISAs for SEMG1 
    antibodies-online kits for SEMG1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR008836 Semenogelin

    Graphical View of Domain Structure for InterPro Entry P04279

    ProtoNet protein and cluster: P04279

    1 Blocks protein domain: IPB008836 Semenogelin

    UniProtKB/Swiss-Prot: SEMG1_HUMAN, P04279
    Similarity: Belongs to the semenogelin family


    Find genes that share domains with SEMG1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEMG1_HUMAN, P04279
    Function: Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory
    gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins
    may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by
    KLK3/PSA
    Function: Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit
    the secretion of pituitary follicle-stimulating hormone

         Genatlas biochemistry entry for SEMG1:
    major protein of seminal fluid,semenogelin 1,(52kDa),tightly linked to SEMG2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding IPI15590901
         
    Find genes that share ontologies with SEMG1           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Svs2 (no phenotypes)

    Find genes that share phenotypes with SEMG1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SEMG1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SEMG1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SEMG1
    SwitchGear 3'UTR luciferase reporter plasmidSEMG1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SEMG1
    Predesigned siRNA for gene silencing in human, mouse, rat SEMG1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SEMG1

    Clone
    Products:
         
    OriGene clones in human, mouse for SEMG1 (see all 10)
    OriGene ORF clones in mouse, rat for SEMG1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEMG1 (NM_003007)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMG1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SEMG1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SEMG1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMG1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SEMG1_HUMAN, P04279: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space TAS1517240
    GO:0030141secretory granule IEA--

    Find genes that share ontologies with SEMG1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SEMG1 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    Amyloids0.68
    2Disease
    Disease


    Find genes that share SuperPaths with SEMG1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SEMG1
        Amyloids


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEMG1
    Interactions:

        GeneGlobe Interaction Network for SEMG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SEMG1 (P042792, 3 ENSP000003618674) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2863015 I2D: score=3 STRING: ENSP00000357292
    SEMG2Q023833, ENSP000003618554I2D: score=2 STRING: ENSP00000361855
    TGM1P227353, ENSP000002067654I2D: score=1 STRING: ENSP00000206765
    PIK3R2O004593, ENSP000002222544I2D: score=1 STRING: ENSP00000222254
    KLK2P201513, ENSP000003135814I2D: score=1 STRING: ENSP00000313581
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007320insemination TAS2912989
    GO:0019953sexual reproduction ----

    Find genes that share ontologies with SEMG1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEMG1

    2 Novoseek inferred chemical compound relationships for SEMG1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 49.7 2 12746846 (1), 8623511 (1)
    zinc 39.8 7 15563730 (4), 18036592 (1), 18425775 (1), 18203809 (1)



    Find genes that share compounds with SEMG1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SEMG1 gene (2 alternative transcripts): 
    NM_003007.3  NM_198139.1  

    Unigene Cluster for SEMG1:

    Semenogelin I
    Hs.1968  [show with all ESTs]
    Unigene Representative Sequence: NM_003007
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372781(uc002xni.2 uc002xnj.2) ENST00000244069
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SEMG1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SEMG1
    SwitchGear 3'UTR luciferase reporter plasmidSEMG1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SEMG1
    Predesigned siRNA for gene silencing in human, mouse, rat SEMG1
    Clone
    Products:
         
    OriGene clones in human, mouse for SEMG1 (see all 10)
    OriGene ORF clones in mouse, rat for SEMG1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEMG1 (NM_003007)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMG1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SEMG1
    OriGene qSTAR qPCR primer pairs in human, mouse for SEMG1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SEMG1
      QuantiTect SYBR Green Assays in human, mouse, rat SEMG1
      QuantiFast Probe-based Assays in human, mouse, rat SEMG1

    Additional mRNA sequence: 

    BC005229.1 BC007096.1 BC011442.1 BC055416.1 BT007177.1 J04440.1 

    10 DOTS entries:

    DT.91880080  DT.317475  DT.92451349  DT.92414680  DT.120835990  DT.100781310  DT.95370278  DT.120835980 
    DT.95155765  DT.95344011 

    Selected AceView cDNA sequences (see all 344):

    M81652 BE673147 AA627898 AA526711 NM_003008 AI799949 AA640146 AA564052 
    AA640182 BF436885 AA588244 AA631140 AA662703 AA689473 AA687705 AI805039 
    AI826511 AA603044 AA587820 AA587817 AA526735 BX103602 AA564176 AI821476 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SEMG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAAGGATG
    SEMG1 Expression
    About this image


    SEMG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Brain (Nervous System)
             Cerebellum
     
     Prostate (Endocrine System)
    SEMG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEMG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1968

    UniProtKB/Swiss-Prot: SEMG1_HUMAN, P04279
    Tissue specificity: Seminal vesicle

        Custom PCR Arrays for SEMG1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SEMG1
    OriGene qSTAR qPCR primer pairs in human, mouse for SEMG1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SEMG1
    QuantiTect SYBR Green Assays in human, mouse, rat SEMG1
    QuantiFast Probe-based Assays in human, mouse, rat SEMG1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and mouse.

    Orthologs for SEMG1 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Svs25 seminal vesicle secretory protein 2   --   2 (84.82 cM) 164235929 


    ENSEMBL Gene Tree for SEMG1 (if available)
    TreeFam Gene Tree for SEMG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SEMG1 gene
    SEMG22  
    1 SIMAP similar gene for SEMG1 using alignment to 4 protein entries:     SEMG1_HUMAN (see all proteins):
    SEMG2

    Find genes that share paralogs with SEMG1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SEMG1 (see all 210)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1922203561,2
    C--43833730(+) TATGAA/GTATAA 1 -- us2k10--------
    rs1412020291,2
    --43833798(+) GTCCAA/GCAGGA 1 -- us2k10--------
    rs1171407691,2
    C,F--43833920(+) TATCAA/GTACAT 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1849570851,2
    --43833990(+) TATAGC/TAATCA 1 -- us2k10--------
    rs169898061,2
    C,F,H--43834091(+) TGAAAG/TTTTTG 1 -- us2k113Minor allele frequency- T:0.04NA NS EA WA 1534
    rs1894204421,2
    --43834104(+) CTTGAC/TCCATA 1 -- us2k10--------
    rs1180985391,2
    F--43834213(+) GTTAGC/GAGACA 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs130370871,2
    C,F,H--43834313(+) ATAAAT/CTTGGT 1 -- us2k123Minor allele frequency- C:0.11NA NS EA WA CSA 2368
    rs1929015721,2
    --43834321(+) GGTAAA/GATCTC 1 -- us2k10--------
    rs1142451031,2
    C,F--43834345(+) GAGAAA/GCCATG 1 -- us2k11Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for SEMG1 (43835638 - 43838414 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SEMG1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663630CNV Deletion23128226
    nsv482068CNV Gain20164927

    Human Gene Mutation Database (HGMD): SEMG1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEMG1
    DNA2.0 Custom Variant and Variant Library Synthesis for SEMG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 182140    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for SEMG1:
    Gastroenteritis

    Find genes that share disorders with SEMG1           About GenesLikeMe

    1 Novoseek inferred disease relationship for SEMG1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    infertility male 55.6 2 9850738 (1), 12632094 (1)


    Export disorders for SEMG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SEMG1 gene, integrated from 10 sources (see all 93):
    (articles sorted by number of sources associating them with SEMG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Semenogelin, the predominant protein in human semen. Primary structure and identification of closely related proteins in the male accessory sex glands and on the spermatozoa. (PubMed id 2912989)1, 2, 3 Lilja H.... Lundwall A. (J. Biol. Chem. 1989)
    2. Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen. (PubMed id 15563730)1, 3, 9 Jonsson M....Malm J. (Biochem. J. 2005)
    3. Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen. (PubMed id 14629036)1, 2, 9 Jensen-Seaman M.I. and Li W.-H. (J. Mol. Evol. 2003)
    4. Semenogelin I: a coagulum forming, multifunctional seminal vesicle protein. (PubMed id 10412373)1, 2, 9 Robert M. and Gagnon C. (Cell. Mol. Life Sci. 1999)
    5. Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20. (PubMed id 1517240)1, 2, 9 Ulvsbaeck M.... Lundwall A. (J. Biol. Chem. 1992)
    6. Analysis of recombinant human semenogelin as an inhibitor of human sperm motility. (PubMed id 19889947)1, 2, 9 Mitra A.... O'Rand M.G. (Biol. Reprod. 2010)
    7. Association of eppin with semenogelin on human spermatozoa. (PubMed id 15590901)1, 2, 9 Wang Z.... Richardson R.T. (Biol. Reprod. 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Reduced polymorphism in the chimpanzee semen coagulating protein, semenogelin I. (PubMed id 14562960)1, 2 Kingan S.B.... Rand D.M. (J. Mol. Evol. 2003)
    10. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6406 HGNC: 10742 AceView: SEMG1andSEMG2 Ensembl:ENSG00000124233 euGenes: HUgn6406
    ECgene: SEMG1 H-InvDB: SEMG1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SEMG1 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/062

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SEMG1 gene:
    Search GeneIP for patents involving SEMG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SEMG1  
     OriGene qPCR primer pairs and template standards for SEMG1   OriGene Protein Over-expression Lysate for SEMG1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SEMG1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SEMG1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SEMG1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SEMG1   OriGene Custom Protein Services for SEMG1  

     
     
     Block miRNA regulation of human, mouse, rat SEMG1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SEMG1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEMG1 Predesigned siRNA for gene silencing in human, mouse, rat SEMG1
     QuantiFast Probe-based Assays in human, mouse, rat SEMG1 QuantiTect SYBR Green Assays in human, mouse, rat SEMG1
     Custom PCR Arrays for SEMG1 Search Chromatin IP Primers for SEMG1
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SEMG1  GeneGlobe Interaction Network for SEMG1
     Regulatory tfbs in SEMG1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SEMG1 GenScript cDNA clones with any tag delivered in your preferred vector for SEMG1
     GenScript Custom Assay Services for SEMG1 GenScript Custom overexpressing Cell Line Services for SEMG1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SEMG1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SEMG1 antibodies
     SEMG1 proteins
     SEMG1 lysates
     Antibodies for SEMG1
     See all of Abcam's Antibodies, Kits and Proteins for SEMG1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for SEMG1
     Proteins for SEMG1
     Antibodies for SEMG1
     ELISAs for SEMG1
     CLIAs for SEMG1



     Browse ESI BIO Cell Lines and PureStem Progenitors for SEMG1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMG1
     SwitchGear 3'UTR luciferase reporter plasmids for SEMG1
     SwitchGear Promoter luciferase reporter plasmids for SEMG1
     ThermoFisher Antibodies for SEMG1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMG1
     Browse compounds at ApexBio
     Search Addgene for plasmids for SEMG1
      Search eBioscience for proteins for SEMG1
      Search eBioscience for elisas for SEMG1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for SEMG1
     antibodies-online antibodies for SEMG1 (26 products)
     antibodies-online kits for SEMG1 (4 products)
     antibodies-online peptides for SEMG1
     antibodies-online proteins for SEMG1 (6 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SEMG1 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4