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Aliases for SEMG1 Gene

Aliases for SEMG1 Gene

  • Semenogelin I 2 3 4 5
  • Cancer/Testis Antigen 103 2 3 4
  • Semen Coagulating Protein 2 3
  • SemG 3 4
  • SgI 3 4
  • DJ172H20.2 3
  • SgI-29 3
  • CT103 3

External Ids for SEMG1 Gene

Previous HGNC Symbols for SEMG1 Gene

  • SEMG

Previous GeneCards Identifiers for SEMG1 Gene

  • GC20P043564
  • GC20P044474
  • GC20P044521
  • GC20P043269
  • GC20P043835
  • GC20P040577

Summaries for SEMG1 Gene

Entrez Gene Summary for SEMG1 Gene

  • The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. This preproprotein is proteolytically processed by the prostate-specific antigen (PSA) protease to generate multiple peptide products that exhibit distinct functions. One of these peptides, SgI-29, is an antimicrobial peptide with antibacterial activity. This proteolysis process also breaks down the gel matrix and allows the spermatozoa to move more freely. This gene and another similar semenogelin gene are present in a gene cluster on chromosome 20. [provided by RefSeq, Feb 2016]

GeneCards Summary for SEMG1 Gene

SEMG1 (Semenogelin I) is a Protein Coding gene. Diseases associated with SEMG1 include Motion Sickness and Male Infertility. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Transport to the Golgi and subsequent modification. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is SEMG2.

UniProtKB/Swiss-Prot for SEMG1 Gene

  • Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA.

  • Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone.

Gene Wiki entry for SEMG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMG1 Gene

Genomics for SEMG1 Gene

Regulatory Elements for SEMG1 Gene

Enhancers for SEMG1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SEMG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SEMG1 Gene

Chromosome:
20
Start:
45,206,997 bp from pter
End:
45,209,773 bp from pter
Size:
2,777 bases
Orientation:
Plus strand

Genomic View for SEMG1 Gene

Genes around SEMG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEMG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEMG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMG1 Gene

Proteins for SEMG1 Gene

  • Protein details for SEMG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04279-SEMG1_HUMAN
    Recommended name:
    Semenogelin-1
    Protein Accession:
    P04279
    Secondary Accessions:
    • Q53ZV0
    • Q53ZV1
    • Q53ZV2
    • Q6X4I9
    • Q6Y809
    • Q6Y822
    • Q6Y823
    • Q86U64
    • Q96QM3

    Protein attributes for SEMG1 Gene

    Size:
    462 amino acids
    Molecular mass:
    52131 Da
    Quaternary structure:
    • Occurs in disulfide-linked complexes which may also contain two less abundant 71- and 76-kDa semenogelin-related polypeptides. Interacts with EPPIN (via C-terminus); Cys-239 is a critical amino acid for both binding to EPPIN.

    Alternative splice isoforms for SEMG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEMG1 Gene

Proteomics data for SEMG1 Gene at MOPED

Post-translational modifications for SEMG1 Gene

  • Rapidly cleaved after ejaculation by KLK3/PSA, resulting in liquefaction of the semen coagulum and the progressive release of motile spermatozoa.
  • Transglutaminase substrate.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SEMG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SEMG1 Gene

Domains & Families for SEMG1 Gene

Protein Domains for SEMG1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SEMG1 Gene

Graphical View of Domain Structure for InterPro Entry

P04279

UniProtKB/Swiss-Prot:

SEMG1_HUMAN :
  • Belongs to the semenogelin family.
Family:
  • Belongs to the semenogelin family.
genes like me logo Genes that share domains with SEMG1: view

No data available for Gene Families for SEMG1 Gene

Function for SEMG1 Gene

Molecular function for SEMG1 Gene

GENATLAS Biochemistry:
major protein of seminal fluid,semenogelin 1,(52kDa),tightly linked to SEMG2
UniProtKB/Swiss-Prot Function:
Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA.
UniProtKB/Swiss-Prot Function:
Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone.

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SEMG1 Gene

Localization for SEMG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMG1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEMG1 Gene COMPARTMENTS Subcellular localization image for SEMG1 gene
Compartment Confidence
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for SEMG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
genes like me logo Genes that share ontologies with SEMG1: view

Pathways & Interactions for SEMG1 Gene

genes like me logo Genes that share pathways with SEMG1: view

Pathways by source for SEMG1 Gene

2 Reactome pathways for SEMG1 Gene

Gene Ontology (GO) - Biological Process for SEMG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007320 insemination TAS 2912989
GO:0019731 antibacterial humoral response IDA 18714013
GO:0019953 sexual reproduction IEA --
GO:0044267 cellular protein metabolic process TAS --
GO:0051291 protein heterooligomerization IDA 8665956
genes like me logo Genes that share ontologies with SEMG1: view

No data available for SIGNOR curated interactions for SEMG1 Gene

Drugs & Compounds for SEMG1 Gene

(2) Drugs for SEMG1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SEMG1: view

Transcripts for SEMG1 Gene

mRNA/cDNA for SEMG1 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(344) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SEMG1 Gene

Semenogelin I:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEMG1 Gene

No ASD Table

Relevant External Links for SEMG1 Gene

GeneLoc Exon Structure for
SEMG1
ECgene alternative splicing isoforms for
SEMG1

Expression for SEMG1 Gene

mRNA expression in normal human tissues for SEMG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEMG1 Gene

This gene is overexpressed in Prostate (x38.7) and Whole Blood (x6.0).

Protein differential expression in normal tissues from HIPED for SEMG1 Gene

This gene is overexpressed in Prostate (58.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SEMG1 Gene



SOURCE GeneReport for Unigene cluster for SEMG1 Gene Hs.1968

mRNA Expression by UniProt/SwissProt for SEMG1 Gene

P04279-SEMG1_HUMAN
Tissue specificity: Seminal vesicle.
genes like me logo Genes that share expression patterns with SEMG1: view

Protein tissue co-expression partners for SEMG1 Gene

Primer Products

Orthologs for SEMG1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SEMG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEMG2 36
  • 59 (a)
OneToOne
Species with no ortholog for SEMG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SEMG1 Gene

ENSEMBL:
Gene Tree for SEMG1 (if available)
TreeFam:
Gene Tree for SEMG1 (if available)

Paralogs for SEMG1 Gene

Paralogs for SEMG1 Gene

(1) SIMAP similar genes for SEMG1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SEMG1: view

Variants for SEMG1 Gene

Sequence variations from dbSNP and Humsavar for SEMG1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs2301366 - 45,207,532(+) ACCAG(A/G/T)CCCGA reference, missense
rs2233887 - 45,208,412(+) CCAAC(A/G/T)CAGTA reference, missense
rs11559137 - 45,207,470(+) AACTG(A/G)ATCCA reference, missense
rs2233884 - 45,207,620(+) GCTCC(A/G)TAATA reference, missense
rs1804436 -- 45,209,701(+) TGCTT(A/C)CTTGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SEMG1 Gene

Variant ID Type Subtype PubMed ID
nsv482068 CNV Gain 20164927
esv2663630 CNV Deletion 23128226

Variation tolerance for SEMG1 Gene

Residual Variation Intolerance Score: 91.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.39; 54.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEMG1 Gene

Human Gene Mutation Database (HGMD)
SEMG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEMG1 Gene

Disorders for SEMG1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SEMG1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
motion sickness
  • motion sickness nos
male infertility
  • infertility male
- elite association - COSMIC cancer census association via MalaCards
Search SEMG1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SEMG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEMG1
genes like me logo Genes that share disorders with SEMG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SEMG1 Gene

Publications for SEMG1 Gene

  1. Semenogelin, the predominant protein in human semen. Primary structure and identification of closely related proteins in the male accessory sex glands and on the spermatozoa. (PMID: 2912989) Lilja H. … Lundwall A. (J. Biol. Chem. 1989) 2 3 4 67
  2. Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen. (PMID: 15563730) Jonsson M. … Malm J. (Biochem. J. 2005) 2 3 23
  3. Analysis of recombinant human semenogelin as an inhibitor of human sperm motility. (PMID: 19889947) Mitra A. … O'Rand M.G. (Biol. Reprod. 2010) 3 23
  4. Functional implications of membrane modification with semenogelins for inhibition of sperm motility in humans. (PMID: 19089943) Yoshida K. … Iwamoto T. (Cell Motil. Cytoskeleton 2009) 3 23
  5. The GPI-anchored CD52 antigen of the sperm surface interacts with semenogelin and participates in clot formation and liquefaction of human semen. (PMID: 17624925) Flori F. … Giovampaola C.D. (Mol. Reprod. Dev. 2008) 3 23

Products for SEMG1 Gene

Sources for SEMG1 Gene

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