Aliases for SEMG1 Gene
External Ids for SEMG1 Gene
Previous HGNC Symbols for SEMG1 Gene
Previous GeneCards Identifiers for SEMG1 Gene
The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. This preproprotein is proteolytically processed by the prostate-specific antigen (PSA) protease to generate multiple peptide products that exhibit distinct functions. One of these peptides, SgI-29, is an antimicrobial peptide with antibacterial activity. This proteolysis process also breaks down the gel matrix and allows the spermatozoa to move more freely. This gene and another similar semenogelin gene are present in a gene cluster on chromosome 20. [provided by RefSeq, Feb 2016]
GeneCards Summary for SEMG1 Gene
SEMG1 (Semenogelin I) is a Protein Coding gene. Diseases associated with SEMG1 include motion sickness and male infertility. Among its related pathways are Transport to the Golgi and subsequent modification and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is SEMG2.
UniProtKB/Swiss-Prot for SEMG1 Gene
Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA.
Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone.