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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEMG1 Gene

protein-coding   GIFtS: 55
GCID: GC20P043835

semenogelin I


(Previous symbol: SEMG)
 Explore 16 diseases affiliated with
SEMG1 via our new
 Human Malady Compendium 
Biological research products
for SEMG1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Semenogelin I1 2 3     Cancer/Testis Antigen 1032
SEMG1 2 3 5     DJ172H20.21
CT1031 2     Semen Coagulating Protein2
SGI2 3     Semenogelin-11

External Ids:    HGNC: 107421   Entrez Gene: 64062   Ensembl: ENSG000001242337   OMIM: 1821405   UniProtKB: P042793   

Export aliases for SEMG1 gene to outside databases

Previous GC identifers: GC20P043564 GC20P044474 GC20P044521 GC20P043269 GC20P040577


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEMG1:
The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the
formation of a gel matrix that encases ejaculated spermatozoa. The prostate-specific antigen (PSA) protease processes
this protein into smaller peptides, with each possibly having a separate function. The proteolysis process breaks down
the gel matrix and allows the spermatozoa to move more freely. (provided by RefSeq, Jul 2009)

UniProtKB/Swiss-Prot: SEMG1_HUMAN, P04279
Function: Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland
secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may
contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA
Function: Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the
secretion of pituitary follicle-stimulating hormone

Gene Wiki entry for SEMG1 (Semenogelin I)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEMG1 gene promoter:
         HOXA3   SREBP-1a   SREBP-1c   IRF-1   Cdc5   SREBP-1b   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEMG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SEMG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12-q13.2   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q12-q13.2

SEMG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMG1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P043835:  view genomic region     (about GC identifiers)

Start:
43,835,638 bp from pter      End:
43,838,414 bp from pter
Size:
2,777 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SEMG1_HUMAN, P04279 (See protein sequence)
Recommended Name: Semenogelin-1 precursor  
Size: 462 amino acids; 52131 Da
Subunit: Occurs in disulfide-linked complexes which may also contain two less abundant 71- and 76-kDa
semenogelin-related polypeptides. Interacts with EPPIN (via C-terminus); Cys-239 is a critical amino acid for both
binding to EPPIN
Subcellular location: Secreted
Secondary accessions: Q53ZV0 Q53ZV1 Q53ZV2 Q6X4I9 Q6Y809 Q6Y822 Q6Y823 Q86U64 Q96QM3
Alternative splicing: 2 isoforms:  P04279-1   P04279-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEMG1: NX_P04279

Post-translational modifications:

  • Transglutaminase substrate1
  • Rapidly cleaved after ejaculation by KLK3/PSA, resulting in liquefaction of the semen coagulum and the progressive
  • release of motile spermatozoa1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P04279

  • SEMG1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002998.1  
    ENSEMBL proteins: 
     ENSP00000361867   ENSP00000244069  
    Reactome Protein details: P04279
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    Uscn Proteins for SEMG1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space TAS1517240
    GO:0030141secretory granule IEA--


    SEMG1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SEMG1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR008836 Semenogelin

    Graphical View of Domain Structure for InterPro Entry P04279

    ProtoNet protein and cluster: P04279

    1 Blocks protein family: IPB008836 Semenogelin

    UniProtKB/Swiss-Prot: SEMG1_HUMAN, P04279
    Similarity: Belongs to the semenogelin family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SEMG1_HUMAN, P04279
    Function: Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland
    secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may
    contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA
    Function: Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the
    secretion of pituitary follicle-stimulating hormone

         Genatlas biochemistry entry for SEMG1:
    major protein of seminal fluid,semenogelin 1,(52kDa),tightly linked to SEMG2

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding IPI15590901


    SEMG1 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Amyloid precursor proteins form ordered fibrils
    Amyloid precursor proteins form ordered fibrils1.00
    Amyloids0.43
    2Disease
    Disease1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for SEMG1
        Amyloids
    Amyloid precursor proteins form ordered fibrils
    Disease



    SEMG1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SEMG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/29 Interacting proteins for SEMG1 (P042792, 3 ENSP000003618674) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2863015 I2D: score=3 STRING: ENSP00000357292
    SEMG2Q023833, ENSP000003618554I2D: score=2 STRING: ENSP00000361855
    TGM1P227353, ENSP000002067654I2D: score=1 STRING: ENSP00000206765
    PIK3R2O004593, ENSP000002222544I2D: score=1 STRING: ENSP00000222254
    KLK2P201513, ENSP000003135814I2D: score=1 STRING: ENSP00000313581
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007320insemination TAS2912989
    GO:0019953sexual reproduction IEA--


    SEMG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SEMG1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEMG1
    2 Novoseek chemical compound relationships for SEMG1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 49.7 2 12746846 (1), 8623511 (1)
    zinc 39.8 7 15563730 (4), 18036592 (1), 18425775 (1), 18203809 (1)

    Search CenterWatch for drugs/clinical trials and news about SEMG1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SEMG1 gene (2 alternative transcripts): 
    NM_003007.3  NM_198139.1  

    Unigene Cluster for SEMG1:

    Semenogelin I
    Hs.1968  [show with all ESTs]
    Unigene Representative Sequence: NM_003007
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372781(uc002xni.2 uc002xnj.2) ENST00000244069

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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMG1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMG1

    Additional cDNA sequence: 

    BC005229.1 BC007096.1 BC011442.1 BC055416.1 BT007177.1 J04440.1 

    10 DOTS entries:

    DT.91880080  DT.317475  DT.92451349  DT.92414680  DT.120835990  DT.100781310  DT.95370278  DT.120835980 
    DT.95155765  DT.95344011 

    24/344 AceView cDNA sequences (see all 344):

    AA640182 AA631140 AI799949 AA564546 BX103602 AI401745 BF436885 NM_003008 
    AA662703 AI821476 AA661650 AI791621 AA593590 AA564531 AI805039 NM_003007 
    AA587820 AA687736 CB051402 M81652 AI420927 BC056675 AA526711 BX101120 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEMG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGAAAGGATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SEMG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEMG1

    SOURCE GeneReport for Unigene cluster: Hs.1968

    UniProtKB/Swiss-Prot: SEMG1_HUMAN, P04279
    Tissue specificity: Seminal vesicle

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for SEMG1 (if available)
    TreeFam Gene Tree for SEMG1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEMG1 gene
    SEMG22  
    1 SIMAP similar gene for SEMG1 using alignment to 4 protein entries:     SEMG1_HUMAN (see all proteins):
    SEMG2

    SEMG1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/156 NCBI SNPs in SEMG1 are shown (see all 156    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1922203561,2
    --43833730(+) TATGAA/GTATAA 1 -- us2k10--------
    rs1412020291,2
    --43833798(+) GTCCAA/GCAGGA 1 -- us2k10--------
    rs1171407691,2
    --43833920(+) TATCAA/GTACAT 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1849570851,2
    --43833990(+) TATAGC/TAATCA 1 -- us2k10--------
    rs169898061,2
    C,F,H,--43834091(+) TGAAAG/TTTTTG 1 -- us2k113Minor allele frequency- T:0.04NA NS EA WA 1534
    rs1894204421,2
    --43834104(+) CTTGAC/TCCATA 1 -- us2k10--------
    rs1180985391,2
    --43834213(+) GTTAGC/GAGACA 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs130370871,2
    C,F,H,--43834313(+) ATAAAT/CTTGGT 1 -- us2k123Minor allele frequency- C:0.11NA NS EA WA CSA 2368
    rs1929015721,2
    --43834321(+) GGTAAA/GATCTC 1 -- us2k10--------
    rs1142451031,2
    F,--43834345(+) GAGAAA/GCCATG 1 -- us2k11Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for SEMG1 (43835638 - 43838414 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SEMG1: --
    Human Gene Mutation Database (HGMD): SEMG1

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SEMG1 for disorders           About GeneDecksing

    OMIM gene information: 182140    OMIM disorders: --

    16 diseases for SEMG1:    About MalaCards
    prostatitis    motion sickness    legionellosis    male infertility
    gastroenteritis    chronic lymphocytic leukemia    fanconi's anemia    lymphocytic leukemia
    infertility    prostate cancer, progression of    prostate cancer    anemia
    colorectal cancer    leukemia    myeloma    ataxia

    1 disease from the University of Copenhagen DISEASES database for SEMG1:
    Gastroenteritis

    1 Novoseek disease relationship for SEMG1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    infertility male 55.6 2 9850738 (1), 12632094 (1)


    Export disorders for SEMG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEMG1 gene, integrated from 9 sources (see all 89):
    (articles sorted by number of sources associating them with SEMG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Semenogelin, the predominant protein in human semen. Primary structure and identification of closely related proteins in the male accessory sex glands and on the spermatozoa. (PubMed id 2912989)1, 2, 3 Lilja H.... Lundwall A. (1989)
    2. Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen. (PubMed id 15563730)1, 3, 9 Jonsson M....Malm J. (2005)
    3. Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen. (PubMed id 14629036)1, 2, 9 Jensen-Seaman M.I. and Li W.-H. (2003)
    4. Semenogelin I: a coagulum forming, multifunctional seminal vesicle protein. (PubMed id 10412373)1, 2, 9 Robert M. and Gagnon C. (1999)
    5. Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20. (PubMed id 1517240)1, 2, 9 Ulvsbaeck M.... Lundwall A. (1992)
    6. Analysis of recombinant human semenogelin as an inhib itor of human sperm motility. (PubMed id 19889947)1, 2, 9 Mitra A....O'Rand M.G. (2010)
    7. Association of eppin with semenogelin on human spermatozoa. (PubMed id 15590901)1, 2, 9 Wang Z....Richardson R.T. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Reduced polymorphism in the chimpanzee semen coagulating protein, semenogelin I. (PubMed id 14562960)1, 2 Kingan S.B.... Rand D.M. (2003)
    10. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6406 HGNC: 10742 AceView: SEMG1andSEMG2 Ensembl:ENSG00000124233 euGenes: HUgn6406
    ECgene: SEMG1 H-InvDB: SEMG1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    NameDescription
    PharmGKB entry for SEMG1 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt062.shtml

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEMG1 gene:
    Search GeneIP for patents involving SEMG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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