SEMA7A Gene

Aliases
for SEMA7A gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC15M070720 GC15M067816 GC15M072278 GC15M072418 GC15M072489 GC15M051497

Summaries
for SEMA7A gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for SEMA7A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000015.9  NT_010194.18  NC_018926.2  

SwitchGear Promoter luciferase reporter plasmid: SEMA7A promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEMA7A

SEMA7A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M074701:  view genomic region     (about GC identifiers)

Proteins
for SEMA7A gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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1 PDB 3D structure from and Proteopedia for SEMA7A:

3NVQ (3D)    

Explore the universe of human proteins at neXtProt for SEMA7A: NX_O75326

Explore proteomics data for SEMA7A at MOPED

Post-translational modifications: 

SEMA7A Human Recombinant Protein Products:

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	antibodies-online proteins for SEMA7A (5 products)
	antibodies-online peptides for SEMA7A

SEMA7A Antibody Products:

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SEMA7A Assay Products:

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	antibodies-online kits for SEMA7A (27 products)

Domains /
Families
for SEMA7A gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: O75326

Find genes that share domains with SEMA7A           About GenesLikeMe

Function
for SEMA7A gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

(inferred from 1 allele) (MGI details for Sema7a)

genOway: Develop your customized and physiologically relevant rodent model for SEMA7A

miRNA Products:		miRTarBase miRNAs that target SEMA7A: hsa-mir-615-3p (MIRT040303)
		Block miRNA regulation of human, mouse, rat SEMA7A using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate SEMA7A (see all 37):
		hsa-miR-323-3p hsa-miR-4328 hsa-miR-106a hsa-miR-513a-5p hsa-miR-128 hsa-miR-485-3p hsa-miR-519a hsa-miR-93
		SwitchGear 3'UTR luciferase reporter plasmid: SEMA7A 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SEMA7A
		Predesigned siRNA for gene silencing in human, mouse, rat SEMA7A

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SEMA7A

Clone Products:		OriGene clones in human, mouse for SEMA7A (see all 18) OriGene ORF clones in mouse, rat for SEMA7A OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): SEMA7A (NM_003612)
		Sino Biological Human cDNA Clone for SEMA7A
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA7A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA7A

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SEMA7A
		Browse ESI BIO Cell Lines and PureStem Progenitors for SEMA7A

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA7A

Localization
for SEMA7A gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	5
cytosol	1
endoplasmic reticulum	1
extracellular	1
golgi apparatus	1
lysosome	1
mitochondrion	1
nucleus	1

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Gene Ontology (GO): 4 cellular component terms:    About this table

Pathways & Interactions
for SEMA7A gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for SEMA7A About     See pathways by source

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	SuperPath	Contained pathways About
1	L1CAM interactions	Axon guidance 0.63 Developmental Biology 0.63
2	Semaphorin interactions	Semaphorin interactions 0.43 Other semaphorin interactions 0.00
3	Semaphorin Signaling	Semaphorin Signaling
4	Axon guidance	Axon guidance

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SEMA7A

Semaphorin Signaling

1 Reactome Pathway for SEMA7A

Other semaphorin interactions

1 Kegg Pathway  (Kegg details for SEMA7A)

Axon guidance

Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

Drugs & Compounds
for SEMA7A gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for SEMA7A gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for SEMA7A gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SEMA7A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTATAACTTA

About this image

Neural Tube (Nervous System)    fully expand to see all 2 entries
Metencephalon
Ovary (Reproductive System)
Mature follicles
Gut Tube (Gastrointestinal Tract)
Foregut
Kidney (Urinary System)
Metanephros
Blood (Hematopoietic System)
Hematopoietic Stem Cells Hematopoietic Bone Marrow

Primer Products:		OriGene qPCR primer pairs and template standards for SEMA7A OriGene qSTAR qPCR primer pairs in human, mouse for SEMA7A
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEMA7A
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		QuantiFast Probe-based Assays in human, mouse, rat SEMA7A

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA7A

Orthologs
for SEMA7A gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for SEMA7A gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for SEMA7A gene

SEMA6D²  SEMA6B²  SEMA6C²  SEMA5A²  SEMA6A²  SEMA5B²  

4 SIMAP similar genes for SEMA7A using alignment to 3 protein entries:     SEM7A_HUMAN (see all proteins):

SEMA3A    SEMA4B    SEMA3C    SEMA3F

Find genes that share paralogs with SEMA7A           About GenesLikeMe

Genomic Variants
for SEMA7A gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SEMA7A (see all 853)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs283629301,2	C,F	--	54752145(-)	GGTGCC/TGGCTG	3	--	ds5001		10		NS NA WA CSA EA	446
rs1889484561,2	C	--	54752192(+)	ACAGGA/GTCGCA	3	--	ds5001		0	--	--	--	--
rs1816361431,2		--	54752238(+)	GGCAGC/GGAGTC	3	--	ds5001		0	--	--	--	--
rs283629291,2	C,F	--	54752357(-)	TCGAGC/ACTTGA	3	--	ds5001		6		NS NA WA	202
rs1498676591,2		--	54752373(+)	CAGCAC/TGCTGC	3	--	ds5001		0	--	--	--	--
rs1138223121,2	C	--	54752680(+)	CCCTGG/TGTGGC	3	--	ut31		0	--	--	--	--
rs283629281,2	C	--	54752718(-)	TTTCAG/TGGGGG	3	--	ut31		3		NS NA	80
rs753190521,2	C	--	54752819(+)	TAACAC/TGTCCT	3	--	ut31		0	--	--	--	--
rs1855099081,2		--	54752883(+)	TGAGAA/GGAAGG	3	--	ut31		0	--	--	--	--
rs283629271,2	C	--	54752956(-)	GAGCCG/AGGTCC	3	--	ut31		3		NS NA	88

HapMap Linkage Disequilibrium report for SEMA7A (74701630 - 74726808 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for SEMA7A (see all 15):    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2749879	CNV	Deletion	23290073
dgv2412n71	CNV	Loss	21882294
nsv904373	CNV	Loss	21882294
esv24909	CNV	Loss	19812545
dgv2413n71	CNV	Loss	21882294
dgv2409n71	CNV	Loss	21882294
dgv2411n71	CNV	Loss	21882294
nsv904371	CNV	Loss	21882294
dgv2406n71	CNV	Loss	21882294
dgv2407n71	CNV	Gain	21882294

Human Gene Mutation Database (HGMD): SEMA7A

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing SEMA7A

DNA2.0 Custom Variant and Variant Library Synthesis for SEMA7A

Disorders / Diseases
for SEMA7A gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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1 disease for SEMA7A

2 Novoseek inferred disease relationships for SEMA7A gene    About this table

Publications
for SEMA7A gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. New eukaryotic semaphorins with close homology to semaphorins of DNA viruses. (PubMed id 9721204)^{1, 2, 3} Lange C.... Ensser A. (Genomics 1998)
2. The molecular diversity of Sema7A, the semaphorin that carries the JMH blood group antigens. (PubMed id 17207242)^{1, 2, 9} Seltsam A.... Blasczyk R. (Transfusion 2007)
3. Semaphorin 7a promotes spreading and dendricity in human melanocytes through beta1-integrins. (PubMed id 17671519)^{1, 2, 9} Scott G.A.... Fricke A.F. (J. Invest. Dermatol. 2008)
4. Association study of semaphorin 7a (sema7a) polymorphisms with bone mineral density and fracture risk in postmenopausal Korean women. (PubMed id 16372136)^{1, 4, 9} Koh J.M....Kim S.Y. (J. Hum. Genet. 2006)
5. Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108. (PubMed id 10201933)^{1, 2, 9} Yamada A.... Itoh K. (J. Immunol. 1999)
6. Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin. (PubMed id 17377534)^{1, 2, 9} Suzuki K.... Kikutani H. (Nature 2007)
7. Semaphorin 7A promotes axon outgrowth through integrins and MAPKs. (PubMed id 12879062)^{1, 2, 9} Pasterkamp R.J.... Kolodkin A.L. (Nature 2003)
8. Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins. (PubMed id 9712866)^{1, 2, 9} Xu X.... Luo Y. (J. Biol. Chem. 1998)
9. Characterization of the human leukocyte GPI-anchored glycoprotein CDw108 and its relation to other similar molecules. (PubMed id 10416131)^{1, 2, 9} Angelisova P.... Horejsi V. (Immunobiology 1999)
10. A new SEMA7A variant found in Native Americans with alloantibody. (PubMed id 20854351)^{1, 2} Richard M.... St-Louis M. (Vox Sang. 2011)

External Searches for SEMA7A gene

Genome Databases showing SEMA7A gene

Other Databases showing SEMA7A gene

Specialized Databases showing SEMA7A gene

Products
for SEMA7A gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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