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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SEMA7A Gene

protein-coding GIFtS: 61
GCID: GC15M074701

semaphorin 7A, GPI membrane anchor (John Milton Hagen blood...

(Previous names: sema domain, immunoglobulin domain (Ig), and GPI membrane...)
(Previous symbol: SEMAL)

Explore 15 diseases affiliated with
SEMA7A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Semaphorin 7A, GPI Membrane Anchor (John Milton Hagen Blood Group)¹ ²		H-SEMA-K1²
SEMAL¹ ² ³ ⁵		John Milton Hagen Blood Group H-Sema K1²
CD108¹ ² ³		Sema Domain, Immunoglobulin Domain (Ig), And GPI Membrane Anchor, 7A²
H-Sema-L¹ ²		Semaphorin K1²
Sema Domain, Immunoglobulin Domain (Ig), And GPI Membrane Anchor, (Semaphorin) 7A (JMH Blood Group)¹ ²		Semaphorin L²
John-Milton-Hargen Human Blood Group Ag² ³		Semaphorin-7A¹
Sema K1² ³		Semaphorin-K1³
Sema L² ³		Semaphorin-L³
CDw108² ³		Semaphorin-K1³
JMH Blood Group Antigen² ³		Semaphorin-L³
JMH² ⁵		CD108 Antigen³
SEMAK1² ⁵		CDW108⁵
Sema Domain, Immunoglobulin Domain (Ig), And GPI Membrane Anchor, (Semaphorin) 7A¹

External Ids:	HGNC: 10741¹	Entrez Gene: 8482²	Ensembl: ENSG00000138623⁷	OMIM: 607961⁵	UniProtKB: O75326³

Export aliases for SEMA7A gene to outside databases

Previous GC identifers: GC15M070720 GC15M067816 GC15M072278 GC15M072418 GC15M072489 GC15M051497

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEMA7A:

The protein encoded by this gene binds to cell surfaces through a glycosylphosphatidylinositol (GPI) linkage. The

encoded glycoprotein is found on activated lymphocytes and erythrocytes. This protein may be involved in

immunomodulatory and neuronal processes. Defects in this gene can result in loss of bone mineral density (BMD). Three

transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Mar 2009)

UniProtKB/Swiss-Prot: SEM7A_HUMAN, O75326

Function: Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and

immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and

subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and

macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon

growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes

Gene Wiki entry for SEMA7A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SEMA7A gene promoter:
AhR Bach1 RP58 Nkx5-1 Arnt E47 AREB6 MRF-2 ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SEMA7A promoter sequence

Search SABiosciences Chromatin IP Primers for SEMA7A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA7A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.3-q23 Ensembl cytogenetic band: 15q24.1 HGNC cytogenetic band: 15q22.3-q23

SEMA7A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA7A gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M074701: view genomic region (about GC identifiers)

Start:	74,701,630 bp from pter	End:	74,726,808 bp from pter
Size:	25,179 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SEM7A_HUMAN, O75326 (See protein sequence)

Recommended Name: Semaphorin-7A precursor

Size: 666 amino acids; 74824 Da

Subunit: Interacts with ITGA1 and ITGB1 (Probable). Interacts with PLXNC1

Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Note=Detected in a punctate pattern

on the cell membrane of basal and supra-basal skin keratinocytes

1 PDB 3D structure from and Proteopedia for SEMA7A:

3NVQ (3D)

Secondary accessions: B4DDP7 F5H1S0 Q1XE81 Q1XE82 Q1XE83 Q1XE84 Q3MIY5

Alternative splicing: 2 isoforms: O75326-1 O75326-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEMA7A: NX_O75326

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O75326

SEMA7A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001139501.1 NP_001139502.1 NP_003603.1

ENSEMBL proteins:

ENSP00000261918 ENSP00000438966 ENSP00000454365 ENSP00000441493

Reactome Protein details: O75326
Human Recombinant Protein Products for SEMA7A:

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	Novus Biologicals SEMA7A Protein Novus Biologicals SEMA7A Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SEMA7A

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0009897	external side of plasma membrane	ISS	--
GO:0016020	membrane	--	--
GO:0031225	anchored to membrane	IEA	--

SEMA7A for ontologies About GeneDecksing

SEMA7A Antibody Products:

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	Uscn Antibodies for SEMA7A
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Assay Products for SEMA7A:

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	Uscn ELISAs and CLIAs for SEMA7A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SEMA7A for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR007110 Ig-like_dom

IPR003659 Plexin-like

IPR003599 Ig_sub

IPR002165 Plexin_repeat

IPR016201 Plexin-like_fold

Graphical View of Domain Structure for InterPro Entry O75326

ProtoNet protein and cluster: O75326

1 Blocks protein family: IPB003599 Immunoglobulin subtype

UniProtKB/Swiss-Prot: SEM7A_HUMAN, O75326

Similarity: Belongs to the semaphorin family

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

Similarity: Contains 1 PSI domain

Similarity: Contains 1 Sema domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SEM7A_HUMAN, O75326

Function: Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and

immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and

subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and

macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon

growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes

Induction: Up-regulated in UV-irradiated fibroblasts, but not in UV-irradiated keratinocytes

Genatlas biochemistry entry for SEMA7A:

semaphorin 7A,74.8kDa,expressed in the placenta,spleen,thymus and gonadal tissues,ligand for the plexin C1,putative

counterpart of the viral semaphorin VB

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0005178	integrin binding	IEA	--
GO:0005515	protein binding	IPI	--

SEMA7A for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for SEMA7A:

Decreased homologous recombina

Synthetic lethal with Ras

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sema7a):

cellular

nervous system

SEMA7A for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Sema7a^tm1Alk for SEMA7A

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SEMA7A

miRNA Products:		OriGene 3'-UTR Clone (see all 3): SEMA7A Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA7A
		8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA7A (see all 37):
		hsa-miR-323-3p hsa-miR-4328 hsa-miR-106a hsa-miR-513a-5p hsa-miR-128 hsa-miR-485-3p hsa-miR-519a hsa-miR-93

		SwitchGear 3'UTR luciferase reporter plasmid: SEMA7A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA7A (see all 7) OriGene shRNA RFP: SEMA7A OriGene siRNA: SEMA7A
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SEMA7A
			Sirion Biotech Customized adenovirus for overexpression of SEMA7A Sirion Biotech Customized adenovirus for potent knockdown of SEMA7A

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA7A (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA7A (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): SEMA7A (NM_003612)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA7A
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SEMA7A
		Search LifeMap BioReagents cell lines for SEMA7A
		Sirion Biotech Customized stable knockdown cell line services for SEMA7A Sirion Biotech Customized inducible knockdown cell line services for SEMA7A Sirion Biotech Customized stable overexpressing cell line services for SEMA7A Sirion Biotech Customized inducible overexpressing cell line services for SEMA7A

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA7A

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Axon guidance

Axon guidance

1.00

Developmental Biology

0.69

Other semaphorin interactions

Other semaphorin interactions

1.00

Semaphorin Signaling

Semaphorin Signaling

1.00

Axon guidance

Axon guidance

1.00

Sema4D in semaphorin signaling

Semaphorin interactions

0.44

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SEMA7A

Semaphorin Signaling

4 Reactome Pathways for SEMA7A

	Developmental Biology
	Semaphorin interactions
	Other semaphorin interactions
	Axon guidance

1 Kegg Pathway (Kegg details for SEMA7A):

Axon guidance

SEMA7A for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SEMA7A

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/8 Interacting proteins for SEMA7A (O75326^{1, 2, 3} ENSP00000261918⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PLXNC1	O60486¹^,³, ENSP00000258526⁴	EBI-1753538,EBI-2927384 I2D: score=3 STRING: ENSP00000258526
NCK1	P16333¹^,³, ENSP00000288986⁴	EBI-1753538,EBI-3448658 I2D: score=1 STRING: ENSP00000288986
ABL1	P00519³, ENSP00000361423⁴	I2D: score=1 STRING: ENSP00000361423
FYN	P06241³, ENSP00000357656⁴	I2D: score=1 STRING: ENSP00000357656
GRB2	P62993³, ENSP00000339007⁴	I2D: score=1 STRING: ENSP00000339007

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006954	inflammatory response	IEA	--
GO:0006955	immune response	TAS	9721204
GO:0007229	integrin-mediated signaling pathway	IDA	12879062
GO:0007275	multicellular organismal development	--	--
GO:0007411	axon guidance	TAS	--

SEMA7A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SEMA7A for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SEMA7A
1 Novoseek chemical compound relationship for SEMA7A gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	0	1	8898942 (1)

Search CenterWatch for drugs/clinical trials and news about SEMA7A / SEM7A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SEMA7A gene (3 alternative transcripts):

NM_001146029.1 NM_001146030.1 NM_003612.3

Unigene Cluster for SEMA7A:

Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)

Hs.24640 [show with all ESTs]

Unigene Representative Sequence: NM_003612

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000261918(uc002axv.3 uc010ull.2) ENST00000543145 ENST00000569617

ENST00000567345 ENST00000542748(uc010ulk.2)

miRNA Products:		OriGene 3'-UTR Clone (see all 3): SEMA7A Browse OriGene MicroRNA Expression Plasmids
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		8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA7A (see all 37):
		hsa-miR-323-3p hsa-miR-4328 hsa-miR-106a hsa-miR-513a-5p hsa-miR-128 hsa-miR-485-3p hsa-miR-519a hsa-miR-93

		SwitchGear 3'UTR luciferase reporter plasmid: SEMA7A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA7A (see all 7) OriGene shRNA RFP: SEMA7A OriGene siRNA: SEMA7A
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA7A

Additional cDNA sequence:

AF030698.1 AF069493.1 AF071542.1 AK001895.1 AK293280.1 AK312257.1 AM180445.1 AM180446.1

AM180447.1 AM180448.1 AM180449.1 AM180450.1 AM180451.1 BC101643.1 BC101647.1

5 DOTS entries:

DT.95157853 DT.110297 DT.121054322 DT.75100409 DT.91702402

24/114 AceView cDNA sequences (see all 114):

BE700453 BE700433 BE700424 AI754587 BE700418 BE700402 AK001895 BE700419

BE700441 BE700437 BE700434 BF363196 BE700411 BE700454 AA856724 BF363202

BU627774 BE700403 BE700414 BE700428 BE700406 BM050767 NM_003612 BE700442

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SEMA7A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTATAACTTA

About this image

SEMA7A expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Adult human kidney epithelial cells (Primary Cell)

Kidney

Mature follicles (In-vitro growth and ...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SEMA7A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEMA7A

SOURCE GeneReport for Unigene cluster: Hs.24640

UniProtKB/Swiss-Prot: SEM7A_HUMAN, O75326

Tissue specificity: Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level).

Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung,

heart, adrenal gland, lymph nodes, thymus, intestine and kidney

SABiosciences Custom PCR Arrays for SEMA7A

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA7A

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA7A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SEMA7A gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SEMA7A¹	semaphorin 7A, GPI membrane anchor (John Milton Hagen more	58.64(n) 49.6(a)		415298 NM_001199749.1 NP_001186678.1
lizard (Anolis carolinensis)	Reptilia	SEMA7A⁶ SEMA3F⁶	--	34(a) 17(a)	1 ↔ 1 possible ortholog	AAWZ02036995(11771-20004) GL343512.1(1500-9205)
zebrafish (Danio rerio)	Actinopterygii	sema7a¹	semaphorin 7A	46.38(n) 38(a)		324910 NM_001114885.1 NP_001108357.1
fruit fly (Drosophila melanogaster)	Insecta	Sema-2a⁶ Sema-2b⁶	Semaphorin-2b	16(a) 15(a)	possible ortholog possible ortholog	2R(12387701-12420934) 2R(12274029-12319263)
worm (Caenorhabditis elegans)	Secernentea	smp-2⁶ mab-20⁶	Semaphorin-2A	16(a) 15(a)	possible ortholog possible ortholog	I(3667127-3671705) I(1644590-1651382)

ENSEMBL Gene Tree for SEMA7A (if available)
TreeFam Gene Tree for SEMA7A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SEMA7A gene

SEMA6D² SEMA6B² SEMA6C² SEMA6A² SEMA5A² SEMA5B²

4 SIMAP similar genes for SEMA7A using alignment to 3 protein entries: SEM7A_HUMAN (see all proteins):

SEMA3A SEMA4B SEMA3C SEMA3F

SEMA7A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: SEM7A_HUMAN, O75326

Polymorphism: Genetic variations in SEMA7A define the John Milton Hagen blood group system (JMH) [MIM:614745]. Three

different JMH phenotypes have been identified based on the presence or absence of the high-frequency JMH antigen:

JMH-weak, JMH-negative, and JMH-variant. The JMH-weak and -negative phenotypes can be either acquired or inherited and

are characterized by a reduction or complete loss of JMH expression on red blood cells. Individuals with the

JMH-variant phenotype are usually JMH-positive and have alloantibodies compatible with JMH-negative red blood cells.

The JMH-variant phenotype results from rare SEMA7A missense variants

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs28362929^1,2	C,F	--	51497222(-)	`TCGAGC/ACTTGA`	3	--	ds500¹		6		NS NA WA	202
rs113822312^1,2	C	--	51497545(+)	`CCCTGG/TGTGGC`	3	--	ut3¹		0	--	--	--	--
rs28362928^1,2	C	--	51497583(-)	`TTTCAG/TGGGGG`	3	--	ut3¹		3		NS NA	80
rs28362927^1,2	C	--	51497822(-)	`GAGCCG/AGGTCC`	3	--	ut3¹		3		NS NA	88
rs28362926^1,2	C,F	--	51498705(-)	`GAGCCG/AGCTGG`	3	--	ut3¹ ese³		5		NS NA WA	216
rs28362925^1,2	C	--	51499244(-)	`CCCCAC/TGTTCA`	3	--	int¹		4		NS NA	98
rs2734640^1,2	H	--	51499566(-)	`GGATAG/TGAGGG`	3	--	int¹		4		NS EA	414
rs2577110^1,2	H	--	51499592(+)	`TCCAGC/TAGAGA`	3	--	int¹		4		NS EA	418
rs2734639^1,2	H	--	51499676(-)	`TGGGAG/CAAGGT`	3	--	int¹		4		NS EA	408
rs56204206^1,2	C	--	51500080(-)	`CTTCCG/ACCGCG`	6	/H /R	mis¹		1		NA	4552

HapMap Linkage Disequilibrium report for SEMA7A (74701630 - 74726808 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SEMA7A
1 Indel: 72285
1 Inversion: 37170

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SEMA7A for disorders           About GeneDecksing

OMIM gene information: 607961    OMIM disorders: --

15 diseases for SEMA7A:    About MalaCards

paroxysmal nocturnal hemoglobinuria hard palate cancer intestinal atresia cardiac sarcoidosis

hemoglobinuria exotropia esotropia pulmonary fibrosis

rheumatoid arthritis melanoma metastasis sarcoidosis melanoma

fibrosis arthritis neuronitis

1 disease from the University of Copenhagen DISEASES database for SEMA7A:

Exotropia

2 Novoseek disease relationships for SEMA7A gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
melanoma	8.16	1	18987670 (1)
tumors	0	1	18987670 (1)

Human Genome Epidemiology (HuGE) Navigator: SEMA7A (1 document)

Export disorders for SEMA7A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SEMA7A gene, integrated from 9 sources (see all 38):
(articles sorted by number of sources associating them with SEMA7A)

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world of online information

New eukaryotic semaphorins with close homology to semaphorins of DNA viruses. (PubMed id 9721204)^{1, 2, 3} Lange C.... Ensser A. (1998)
The molecular diversity of Sema7A, the semaphorin that carries the JMH blood group antigens. (PubMed id 17207242)^{1, 2, 9} Seltsam A.... Blasczyk R. (2007)
Semaphorin 7a promotes spreading and dendricity in human melanocytes through beta1-integrins. (PubMed id 17671519)^{1, 2, 9} Scott G.A....Fricke A.F. (2008)
Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108. (PubMed id 10201933)^{1, 2, 9} Yamada A.... Itoh K. (1999)
Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin. (PubMed id 17377534)^{1, 2, 9} Suzuki K....Kikutani H. (2007)
Semaphorin 7A promotes axon outgrowth through integrins and MAPKs. (PubMed id 12879062)^{1, 2, 9} Pasterkamp R.J....Kolodkin A.L. (2003)
Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins. (PubMed id 9712866)^{1, 2, 9} Xu X.... Luo Y. (1998)
Characterization of the human leukocyte GPI-anchored glycoprotein CDw108 and its relation to other similar molecules. (PubMed id 10416131)^{1, 2, 9} Angelisova P.... Horejsi V. (1999)
A new SEMA7A variant found in Native Americans with a lloantibody. (PubMed id 20854351)^{1, 2} Richard M....St-Louis M. (2011)
Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1. (PubMed id 20727575)^{1, 2} Liu H....He X. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8482	HGNC: 10741	AceView: SEMA7A	Ensembl:ENSG00000138623	euGenes: HUgn8482
ECgene: SEMA7A	Kegg: 8482	H-InvDB: SEMA7A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SEMA7A	Pharmacogenomics, SNPs, Pathways
dbRBC/BGMUT	http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=jmh
SeattleSNPs	http://pga.gs.washington.edu/data/sema7a/

Intellectual Property for SEMA7A gene
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Patent Information for SEMA7A gene:
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GeneCards and IP:
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SEMA7A Gene

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SEMA7A (Gene Symbol)
Semaphorin 7A, GPI Membrane Anchor (John Milton Hagen Blood Group)
SEMAL
CD108
H-Sema-L
Sema Domain, Immunoglobulin Domain (Ig), And GPI Membrane Anchor, (Semaphorin) 7A (JMH Blood Group)
John-Milton-Hargen Human Blood Group Ag
Sema K1
Sema L
CDw108
JMH Blood Group Antigen
JMH
SEMAK1
Sema Domain, Immunoglobulin Domain (Ig), And GPI Membrane Anchor, (Semaphorin) 7A
H-SEMA-K1
John Milton Hagen Blood Group H-Sema K1
Sema Domain, Immunoglobulin Domain (Ig), And GPI Membrane Anchor, 7A
Semaphorin K1
Semaphorin L
Semaphorin-7A
Semaphorin-K1
Semaphorin-L
Semaphorin-K1
Semaphorin-L
CD108 Antigen
CDW108

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SEMA7A Gene

semaphorin 7A, GPI membrane anchor (John Milton Hagen blood...

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