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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SEMA6C Gene

protein-coding GIFtS: 53
GCID: GC01M151104

sema domain, transmembrane domain (TM), and cytoplasmic...

Explore 3 diseases affiliated with
SEMA6C via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sema Domain, Transmembrane Domain (TM), And Cytoplasmic Domain, (Semaphorin) 6C¹ ²		M-SemaY2¹
KIAA1869¹ ³		Semaphorin-6C¹
Sema Y² ³		Semaphorin-Y³
SEMAY² ³		Semaphorin-Y³
M-SemaY¹

External Ids:	HGNC: 10740¹	Entrez Gene: 10500²	Ensembl: ENSG00000143434⁷	OMIM: 609294⁵	UniProtKB: Q9H3T2³

Export aliases for SEMA6C gene to outside databases

Previous GC identifers: GC01M148946 GC01M146851 GC01M147879 GC01M148320 GC01M147918 GC01M149370 GC01M122481

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEMA6C:

This gene encodes a member of the semaphorin family. Semaphorins represent important molecular signals controlling

multiple aspects of the cellular response that follows CNS injury, and thus may play an important role in neural

regeneration. (provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: SEM6C_HUMAN, Q9H3T2

Function: Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal

for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the

maintenance and remodeling of neuronal connections

Gene Wiki entry for SEMA6C

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SEMA6C gene promoter:
PPAR-alpha Spz1 Tal-1 MAZR RREB-1 Olf-1 Nkx2-5 TGIF E47
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SEMA6C promoter sequence

Search SABiosciences Chromatin IP Primers for SEMA6C

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA6C

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21.2

SEMA6C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA6C gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M151104: view genomic region (about GC identifiers)

Start:	151,104,161 bp from pter	End:	151,119,140 bp from pter
Size:	14,980 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SEM6C_HUMAN, Q9H3T2 (See protein sequence)

Recommended Name: Semaphorin-6C precursor

Size: 930 amino acids; 99686 Da

Subcellular location: Cell membrane; Single-pass type I membrane protein

Sequence caution: Sequence=BAB47498.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: D3DV15 Q5JR71 Q5JR72 Q5JR73 Q8WXT8 Q8WXT9 Q8WXU0 Q96JF8

Alternative splicing: 3 isoforms: Q9H3T2-1 Q9H3T2-2 Q9H3T2-3

Explore the universe of human proteins at neXtProt for SEMA6C: NX_Q9H3T2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9H3T2

SEMA6C Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001171532.1 NP_001171533.1 NP_112175.2

ENSEMBL proteins:

ENSP00000357909 ENSP00000357908 ENSP00000357910 ENSP00000344148

Human Recombinant Protein Products for SEMA6C:

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	Novus Biologicals SEMA6C Proteins Novus Biologicals SEMA6C Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SEMA6C

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

SEMA6C for ontologies About GeneDecksing

SEMA6C Antibody Products:

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	Uscn ELISAs and CLIAs for SEMA6C

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SEMA6C for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR003659 Plexin-like

IPR002165 Plexin_repeat

IPR016201 Plexin-like_fold

IPR015514 Semaphorin_6C

IPR027231 Semaphorin

Graphical View of Domain Structure for InterPro Entry Q9H3T2

ProtoNet protein and cluster: Q9H3T2

1 Blocks protein family: IPB001627 Semaphorin/CD100 antigen

UniProtKB/Swiss-Prot: SEM6C_HUMAN, Q9H3T2

Similarity: Belongs to the semaphorin family

Similarity: Contains 1 PSI domain

Similarity: Contains 1 Sema domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SEM6C_HUMAN, Q9H3T2

Function: Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal

for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the

maintenance and remodeling of neuronal connections

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0030215	semaphorin receptor binding	IEA	--

SEMA6C for ontologies About GeneDecksing

Phenotypes:
3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Sema6c):

behavior/neurological

immune system

integument

SEMA6C for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Sema6c^tm1Matl for SEMA6C

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SEMA6C

miRNA Products:		OriGene 3'-UTR Clone: SEMA6C Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA6C
		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA6C (see all 14):
		hsa-miR-3910 hsa-miR-658 hsa-miR-1301 hsa-miR-1184 hsa-miR-124 hsa-miR-149 hsa-miR-625 hsa-miR-3131

		SwitchGear 3'UTR luciferase reporter plasmid: SEMA6C 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA6C (see all 7) OriGene shRNA RFP: SEMA6C OriGene siRNA: SEMA6C
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		Sirion Biotech Custom design and validation of potent shRNA sequences against SEMA6C

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SEMA6C
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA6C (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA6C (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): SEMA6C (NM_030913)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA6C

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Axon guidance

Axon guidance

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Kegg Pathway (Kegg details for SEMA6C):

Axon guidance

SEMA6C for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SEMA6C

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007399	nervous system development	--	--
GO:0007411	axon guidance	IEA	--
GO:0030154	cell differentiation	--	--

SEMA6C for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SEMA6C
Search CenterWatch for drugs/clinical trials and news about SEMA6C / SEM6C

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SEMA6C gene (3 alternative transcripts):

NM_001178061.1 NM_001178062.1 NM_030913.4

Unigene Cluster for SEMA6C:

Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C

Hs.516316 [show with all ESTs]

Unigene Representative Sequence: NM_001178061

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000368913 ENST00000368912 ENST00000368914(uc001ewv.3 uc001ewu.3 uc001eww.3 uc009wml.2)

ENST00000341697 ENST00000479820 ENST00000464018 ENST00000489944 ENST00000485745

miRNA Products:		OriGene 3'-UTR Clone: SEMA6C Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA6C
		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA6C (see all 14):
		hsa-miR-3910 hsa-miR-658 hsa-miR-1301 hsa-miR-1184 hsa-miR-124 hsa-miR-149 hsa-miR-625 hsa-miR-3131

		SwitchGear 3'UTR luciferase reporter plasmid: SEMA6C 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA6C (see all 7) OriGene shRNA RFP: SEMA6C OriGene siRNA: SEMA6C
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA6C
		Sirion Biotech Custom design and validation of potent shRNA sequences against SEMA6C

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA6C (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA6C (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): SEMA6C (NM_030913)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA6C
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEMA6C Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SEMA6C
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA6C
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA6C

Additional cDNA sequence:

AB022434.1 AF055020.1 AF339152.1 AF339153.1 AF339154.1 AK302862.1 AK311613.1 AL122064.1

BC114521.1 BC114623.1

9 DOTS entries:

DT.95155216 DT.454780 DT.97819424 DT.102823833 DT.97837576 DT.92422982 DT.97837577 DT.70101876

DT.91657069

24/55 AceView cDNA sequences (see all 55):

BP348665 CD671385 AW074352 AB058772 AI124683 NM_030913 C20820 BX279977

BE257098 AU252719 BI522560 AF055020 CB045757 W32459 AL122064 R59527

AL705352 AU279414 BF931982 BG120187 AB022434 BM724963 AF339153 BE253393

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for SEMA6C (see all 12) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	^	9	^	10a	·	10b	·	10c	^	11	^	12a	·	12b	^	13a	·	13b	^	14	^
SP1:					-		-		-		-				-				-		-
SP2:
SP3:					-		-		-		-				-		-		-
SP4:																																							-
SP5:

ExUns:	15a	·	15b	^	16	^	17	^	18	^	19	^	20	^	21a	·	21b
SP1:
SP2:													-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for SEMA6C

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SEMA6C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

SEMA6C expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SEMA6C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEMA6C

SOURCE GeneReport for Unigene cluster: Hs.516316

UniProtKB/Swiss-Prot: SEM6C_HUMAN, Q9H3T2

Tissue specificity: In adult tissues, expressed only in skeletal muscle

SABiosciences Custom PCR Arrays for SEMA6C

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA6C

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA6C

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SEMA6C gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC100859892¹	semaphorin-6C-like	57.39(n) 52.31(a)		100859892 XM_003642677.1 XP_003642725.1
lizard (Anolis carolinensis)	Reptilia	SEMA6C⁶ --	--	66(a) 15(a)	1 ↔ 1 possible ortholog	GL344595.1(4115-15015) GL343757.1(650-4500)
zebrafish (Danio rerio)	Actinopterygii	sema6d⁶ sema6e⁶	sema domain, transmembrane domain (TM), and cytopl... sema domain, transmembrane domain (TM), and cytopl...	41(a) 39(a)	1 ↔ many 1 ↔ many	19(400160-427243) 16(32470419-32621272)
fruit fly (Drosophila melanogaster)	Insecta	Sema-1b³	axon guidance	36(a) (best of 4)		--
worm (Caenorhabditis elegans)	Secernentea	mab-20³	Expression: ray cell precursors, ventral nerve more	28(a)		I(1644872-1651256) --

ENSEMBL Gene Tree for SEMA6C (if available)
TreeFam Gene Tree for SEMA6C (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SEMA6C gene

SEMA6D² SEMA6B² SEMA7A² SEMA6A² SEMA5A² SEMA5B²

9 SIMAP similar genes for SEMA6C using alignment to 3 protein entries: SEM6C_HUMAN (see all proteins):

DKFZp434M231 SEMA6D SEMA6A SEMA6B SEMA5B SEMA3A

SEMA4A SEMA4D SEMA3F

SEMA6C for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11586654^1,2	C,F,H	--	122481304(+)	`GGGGTG/CGCTAA`	3	--	ds500¹		2		NA	126
rs115066177^1,2	C,F	--	122481560(+)	`AGACTA/GGGCCT`	3	--	ut3¹		1		WA	118
rs11204781^1,2	F	--	122481606(+)	`GCTCCG/AAGGGC`	3	--	ut3¹ ese³		2		WA EA	238
rs41267548^1,2		--	122481810(+)	`CTGCCA/GCCCTC`	3	--	ut3¹		0	--	--	--	--
rs41267550^1,2		--	122482152(+)	`GACTCG/TGCGAG`	3	--	ut3¹		0	--	--	--	--
rs12058128^1,2	C,F	--	122483425(+)	`TCAGCC/TTCACT`	3	--	int¹		2		WA NA	238
rs78079823^1,2	F	--	122484107(+)	`AGAATG/ACTGCT`	3	--	int¹		1		WA	118
rs12085364^1,2	F	--	122484135(+)	`CACACA/GCTCAG`	3	--	int¹		2		WA EA	238
rs12090246^1,2	C,F,H	--	122484808(+)	`TTGCTG/ACCCAC`	3	--	int¹		14		NS EA NA WA	1890
rs200013494^1,2	C	--	122484997(-)	`GTATTG/TTCTAC`	6	V F	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SEMA6C (151104161 - 151119140 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SEMA6C: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEMA6C

DNA2.0 Custom Variant and Variant Library Synthesis for SEMA6C

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SEMA6C for disorders           About GeneDecksing

OMIM gene information: 609294    OMIM disorders: --

3 diseases for SEMA6C:    About MalaCards

status epilepticus schizophrenia neuronitis

Human Genome Epidemiology (HuGE) Navigator: SEMA6C (1 document)

Export disorders for SEMA6C gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SEMA6C gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with SEMA6C)

Utopia: connect your pdf to the dynamic
world of online information

Identification, characterization, and functional study of the two novel human members of the semaphorin gene family. (PubMed id 12110693)^{1, 2, 3} Qu X.... He F. (2002)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)^{1, 2} Nagase T.... Ohara O. (2001)
Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. (PubMed id 19054571)¹ GregA^rio S.P....Dias-Neto E. (2009)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. (PubMed id 12878157)¹ Imabayashi H.... Umezawa A. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Emerging roles for semaphorins in neural regeneration. (PubMed id 11245885)¹ Pasterkamp R.J. and Verhaagen J. (2001)
Large-scale concatenation cDNA sequencing. (PubMed id 9110174)¹ Yu W.... Gibbs R.A. (1997)
A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)¹ Andersson B.... Gibbs R.A. (1996)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10500	HGNC: 10740	AceView: SEMA6C	Ensembl:ENSG00000143434	euGenes: HUgn10500
ECgene: SEMA6C	Kegg: 10500	H-InvDB: SEMA6C

(According to HUGE)
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HUGE: KIAA1869

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SEMA6C	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SEMA6C gene
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Patent Information for SEMA6C gene:
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