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Aliases for SEMA6C Gene

Aliases for SEMA6C Gene

  • Sema Domain, Transmembrane Domain (TM), And Cytoplasmic Domain, (Semaphorin) 6C 2 3
  • Semaphorin-Y 3 4
  • Sema Y 3 4
  • SEMAY 3 4
  • Semaphorin-6C 3
  • M-Sema Y2 2
  • M-SemaY2 3
  • KIAA1869 4
  • M-SemaY 3

External Ids for SEMA6C Gene

Previous GeneCards Identifiers for SEMA6C Gene

  • GC01M148946
  • GC01M146851
  • GC01M147879
  • GC01M148320
  • GC01M147918
  • GC01M149370
  • GC01M122481

Summaries for SEMA6C Gene

Entrez Gene Summary for SEMA6C Gene

  • This gene encodes a member of the semaphorin family. Semaphorins represent important molecular signals controlling multiple aspects of the cellular response that follows CNS injury, and thus may play an important role in neural regeneration. [provided by RefSeq, May 2010]

GeneCards Summary for SEMA6C Gene

SEMA6C (Sema Domain, Transmembrane Domain (TM), And Cytoplasmic Domain, (Semaphorin) 6C) is a Protein Coding gene. Among its related pathways are Axon guidance. GO annotations related to this gene include receptor activity and semaphorin receptor binding. An important paralog of this gene is SEMA6B.

UniProtKB/Swiss-Prot for SEMA6C Gene

  • Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections.

Gene Wiki entry for SEMA6C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMA6C Gene

Genomics for SEMA6C Gene

Regulatory Elements for SEMA6C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SEMA6C Gene

Start:
151,131,685 bp from pter
End:
151,146,670 bp from pter
Size:
14,986 bases
Orientation:
Minus strand

Genomic View for SEMA6C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEMA6C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA6C Gene

Proteins for SEMA6C Gene

  • Protein details for SEMA6C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3T2-SEM6C_HUMAN
    Recommended name:
    Semaphorin-6C
    Protein Accession:
    Q9H3T2
    Secondary Accessions:
    • D3DV15
    • Q5JR71
    • Q5JR72
    • Q5JR73
    • Q8WXT8
    • Q8WXT9
    • Q8WXU0
    • Q96JF8

    Protein attributes for SEMA6C Gene

    Size:
    930 amino acids
    Molecular mass:
    99686 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47498.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SEMA6C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEMA6C Gene

Proteomics data for SEMA6C Gene at MOPED

Post-translational modifications for SEMA6C Gene

  • Glycosylation at Asn70, Asn286, and Asn437
  • Modification sites at PhosphoSitePlus

Other Protein References for SEMA6C Gene

No data available for DME Specific Peptides for SEMA6C Gene

Domains for SEMA6C Gene

Gene Families for SEMA6C Gene

HGNC:

Suggested Antigen Peptide Sequences for SEMA6C Gene

Graphical View of Domain Structure for InterPro Entry

Q9H3T2

UniProtKB/Swiss-Prot:

SEM6C_HUMAN :
  • Q9H3T2
Domain:
  • Contains 1 PSI domain.
  • Contains 1 Sema domain.
Family:
  • Belongs to the semaphorin family.
genes like me logo Genes that share domains with SEMA6C: view

Function for SEMA6C Gene

Molecular function for SEMA6C Gene

UniProtKB/Swiss-Prot Function: Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections.

Gene Ontology (GO) - Molecular Function for SEMA6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0005515 protein binding --
GO:0030215 semaphorin receptor binding IEA --
genes like me logo Genes that share ontologies with SEMA6C: view

Phenotypes for SEMA6C Gene

genes like me logo Genes that share phenotypes with SEMA6C: view

Animal Models for SEMA6C Gene

MGI Knock Outs for SEMA6C:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEMA6C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SEMA6C Gene

Localization for SEMA6C Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA6C Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEMA6C Gene COMPARTMENTS Subcellular localization image for SEMA6C gene
Compartment Confidence
plasma membrane 5
extracellular 3
lysosome 1

Gene Ontology (GO) - Cellular Components for SEMA6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SEMA6C: view

Pathways for SEMA6C Gene

SuperPathways for SEMA6C Gene

Superpath Contained pathways
1 Axon guidance
genes like me logo Genes that share pathways with SEMA6C: view

Pathways by source for SEMA6C Gene

1 KEGG pathway for SEMA6C Gene

Interacting Proteins for SEMA6C Gene

Gene Ontology (GO) - Biological Process for SEMA6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development --
GO:0007411 axon guidance IEA --
genes like me logo Genes that share ontologies with SEMA6C: view

Transcripts for SEMA6C Gene

Unigene Clusters for SEMA6C Gene

Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEMA6C

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SEMA6C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA6C Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^
SP1: - - - - - - -
SP2:
SP3: - - - - - - -
SP4: -
SP5:
SP6:
SP7: - - -
SP8: - - - - -
SP9:
SP10:
SP11:
SP12:

ExUns: 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for SEMA6C Gene

GeneLoc Exon Structure for
SEMA6C
ECgene alternative splicing isoforms for
SEMA6C

Expression for SEMA6C Gene

mRNA expression in normal human tissues for SEMA6C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEMA6C Gene

This gene is overexpressed in Muscle - Skeletal (10.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SEMA6C Gene

SOURCE GeneReport for Unigene cluster for SEMA6C Gene Hs.516316

mRNA Expression by UniProt/SwissProt for SEMA6C Gene

Q9H3T2-SEM6C_HUMAN
Tissue specificity: In adult tissues, expressed only in skeletal muscle.
genes like me logo Genes that share expressions with SEMA6C: view

In Situ Assay Products

Orthologs for SEMA6C Gene

This gene was present in the common ancestor of animals.

Orthologs for SEMA6C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEMA6C 35
  • 99.69 (n)
  • 99.48 (a)
SEMA6C 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SEMA6C 35
  • 89.66 (n)
  • 90.11 (a)
SEMA6C 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEMA6C 35
  • 87.93 (n)
  • 87.3 (a)
SEMA6C 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sema6c 35
  • 86.34 (n)
  • 87.7 (a)
Sema6c 16
Sema6c 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEMA6C 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 31 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Sema6c 35
  • 87.06 (n)
  • 88.31 (a)
chicken
(Gallus gallus)
Aves LOC100859892 35
  • 59.94 (n)
  • 56.95 (a)
SEMA6C 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEMA6C 36
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii sema6d 36
  • 43 (a)
OneToMany
sema6e 36
  • 41 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Sema-2a 36
  • 28 (a)
ManyToMany
Sema-2b 36
  • 24 (a)
ManyToMany
Sema-1b 37
  • 36 (a)
Sema-1a 37
  • 35 (a)
Sema-2a 37
  • 33 (a)
CG4383 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea mab-20 37
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToMany
Species with no ortholog for SEMA6C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SEMA6C Gene

ENSEMBL:
Gene Tree for SEMA6C (if available)
TreeFam:
Gene Tree for SEMA6C (if available)

Paralogs for SEMA6C Gene

Paralogs for SEMA6C Gene

Selected SIMAP similar genes for SEMA6C Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SEMA6C: view

Variants for SEMA6C Gene

Sequence variations from dbSNP and Humsavar for SEMA6C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3811402 -- 151,147,269(+) GAAAG(C/G)AAGGT upstream-variant-2KB
rs3811403 -- 151,148,186(+) AAAGA(C/T)ACCTC upstream-variant-2KB
rs3841058 -- 151,148,047(+) GATCT(-/A)AAAAA upstream-variant-2KB
rs3892218 -- 151,141,606(-) TGGTG(A/G)AACCC intron-variant
rs4387181 -- 151,140,859(+) CAGGC(A/G)TGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEMA6C Gene

Variant ID Type Subtype PubMed ID
nsv522840 CNV Gain 19592680
dgv385n71 CNV Loss 21882294
dgv2n68 CNV Loss 17160897

Relevant External Links for SEMA6C Gene

HapMap Linkage Disequilibrium report
SEMA6C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEMA6C Gene

Disorders for SEMA6C Gene

Relevant External Links for SEMA6C

Genetic Association Database (GAD)
SEMA6C
Human Genome Epidemiology (HuGE) Navigator
SEMA6C
genes like me logo Genes that share disorders with SEMA6C: view

No data available for UniProtKB/Swiss-Prot for SEMA6C Gene

Publications for SEMA6C Gene

  1. Identification, characterization, and functional study of the two novel human members of the semaphorin gene family. (PMID: 12110693) Qu X. … He F. (J. Biol. Chem. 2002) 2 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. (PMID: 19054571) GregA^rio S.P. … Dias-Neto E. (Psychiatry Res 2009) 3 48
  4. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SEMA6C Gene

  • antibodies-online proteins for SEMA6C
  • antibodies-online antibodies for SEMA6C
  • antibodies-online kits for SEMA6C

Sources for SEMA6C Gene

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