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SEMA6B Gene

protein-coding   GIFtS: 50
GCID: GC19M004542

Sema Domain, Transmembrane Domain (TM), And Cytoplasmic...


(Previous symbol: SEMAN)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sema Domain, Transmembrane Domain (TM), And Cytoplasmic Domain,
(Semaphorin) 6B1 2
     semaZ2
SEMAN1 2 3     semaphorin-6B2
Semaphorin VIB1 2     semaphorin-6Ba2
Semaphorin Z1 2     SEMAZ3
Sema VIb1     Semaphorin-Z3
SEM-SEMA-Y2     Sema Z3
SEMA-VIB2     

External Ids:    HGNC: 107391   Entrez Gene: 105012   Ensembl: ENSG000001676807   OMIM: 6088735   UniProtKB: Q9H3T33   

Export aliases for SEMA6B gene to outside databases

Previous GC identifers: GC19M004634 GC19M004482 GC19M004493 GC19M004304


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SEMA6B Gene:
This gene encodes a member of the semaphorin family, a group of proteins characterized by the presence of a
conserved semaphorin (sema) domain. Whereas some semaphorins are transmembrane proteins, others are secreted.
Semaphorins play a major role in axon guidance. The protein encoded by this gene may be involved in both
peripheral and central nervous system development. (provided by RefSeq, Jul 2008)

GeneCards Summary for SEMA6B Gene:
SEMA6B (sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B) is a protein-coding gene. Diseases associated with SEMA6B include periodontitis, and breast cancer. GO annotations related to this gene include semaphorin receptor binding and receptor activity. An important paralog of this gene is SEMA6D.

UniProtKB/Swiss-Prot: SEM6B_HUMAN, Q9H3T3
Function: May play a role in both peripheral and central nervous system development (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEMA6B gene promoter:
         c-Fos   AP-1   JunB   Fra-1   FosB   MZF-1   Egr-2   JunD   c-Jun   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEMA6B promoter sequence
   Search Chromatin IP Primers for SEMA6B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEMA6B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

SEMA6B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA6B gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M004542:  view genomic region     (about GC identifiers)

Start:
4,542,600 bp from pter      End:
4,559,820 bp from pter
Size:
17,221 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SEM6B_HUMAN, Q9H3T3 (See protein sequence)
Recommended Name: Semaphorin-6B precursor  
Size: 888 amino acids; 95285 Da
Sequence caution: Sequence=AAF87661.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Secondary accessions: A5PKU4 F6IB19 Q9NRK9
Alternative splicing: 2 isoforms:  Q9H3T3-1   Q9H3T3-3   

Explore the universe of human proteins at neXtProt for SEMA6B: NX_Q9H3T3

Explore proteomics data for SEMA6B at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn74, Asn155, Asn167, Asn291, Asn386, Asn441, Asn462
  • Modification sites at PhosphoSitePlus

  • See SEMA6B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115484.2  
    ENSEMBL proteins: 
     ENSP00000467290   ENSP00000465722   ENSP00000301293  

    SEMA6B Human Recombinant Protein Products:

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    Novus Biologicals SEMA6B Protein
    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for SEMA6B

    SEMA6B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for SEMA6B

    SEMA6B Assay Products:

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    Cloud-Clone Corp. ELISAs for SEMA6B
    Cloud-Clone Corp. CLIAs for SEMA6B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SEMA: Semaphorins

    5 InterPro protein domains:
     IPR002165 Plexin_repeat
     IPR027231 Semaphorin
     IPR001627 Semap_dom
     IPR016201 Plexin-like_fold
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9H3T3

    ProtoNet protein and cluster: Q9H3T3

    1 Blocks protein domain: IPB001627 Semaphorin/CD100 antigen

    UniProtKB/Swiss-Prot: SEM6B_HUMAN, Q9H3T3
    Similarity: Belongs to the semaphorin family
    Similarity: Contains 1 Sema domain


    SEMA6B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEM6B_HUMAN, Q9H3T3
    Function: May play a role in both peripheral and central nervous system development (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----
    GO:0030215semaphorin receptor binding IEA--
         
    SEMA6B for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Sema6b):
     nervous system 

    SEMA6B for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEMA6B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SEMA6B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEMA6B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEMA6B

    miRNA
    Products:
        
    miRTarBase miRNAs that target SEMA6B:
    hsa-mir-19b-3p (MIRT031258)

    Block miRNA regulation of human, mouse, rat SEMA6B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEMA6B (see all 22):
    hsa-miR-30c hsa-miR-185* hsa-miR-30d hsa-miR-520a-5p hsa-miR-218 hsa-miR-3150a-3p hsa-miR-30a hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidSEMA6B 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat SEMA6B

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for SEMA6B (see all 6)
    OriGene ORF clones in mouse, rat for SEMA6B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEMA6B (NM_032108)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA6B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA6B

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SEMA6B 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA6B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SEM6B_HUMAN, Q9H3T3: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    SEMA6B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SEMA6B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Axon guidance

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for SEMA6B):
        Axon guidance


    SEMA6B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEMA6B
    Interactions:

        Search GeneGlobe Interaction Network for SEMA6B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for SEMA6B (ENSP000003012934) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLXNA2ENSP000003560004STRING: ENSP00000356000
    PLXNA4ENSP000003231944STRING: ENSP00000323194
    PTK7ENSP000002304194STRING: ENSP00000230419
    ABL1ENSP000003614234STRING: ENSP00000361423
    NCAM1ENSP000003184724STRING: ENSP00000318472
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development ----
    GO:0007399nervous system development IEA--
    GO:0030154cell differentiation IEA--

    SEMA6B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEMA6B (SEM6B)

    1 Novoseek inferred chemical compound relationship for SEMA6B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 43.1 3 16525649 (3)



    SEMA6B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SEMA6B gene (3 alternative transcripts): 
    NM_032108.3  NM_020241.2  NM_133327.1  

    Unigene Cluster for SEMA6B:

    Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
    Hs.465642  [show with all ESTs]
    Unigene Representative Sequence: BC142617
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000586582 ENST00000586965 ENST00000589889 ENST00000301293(uc010dud.2 uc010xih.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SEMA6B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEMA6B (see all 22):
    hsa-miR-30c hsa-miR-185* hsa-miR-30d hsa-miR-520a-5p hsa-miR-218 hsa-miR-3150a-3p hsa-miR-30a hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidSEMA6B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SEMA6B
    Predesigned siRNA for gene silencing in human, mouse, rat SEMA6B
    Clone
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    OriGene ORF clones in mouse, rat for SEMA6B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEMA6B (NM_032108)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA6B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA6B
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SEMA6B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEMA6B
      QuantiTect SYBR Green Assays in human, mouse, rat SEMA6B
      QuantiFast Probe-based Assays in human, mouse, rat SEMA6B

    Additional mRNA sequence: 

    AB022433.1 AB209278.1 AF216389.1 AF293363.1 AK300037.1 AY358939.1 BC142617.1 FR839673.1 

    2 DOTS entries:

    DT.95368944  DT.100742029 

    Selected AceView cDNA sequences (see all 47):

    CR591947 NM_032108 R87331 BQ637712 T08532 BQ184207 CB268087 BF973615 
    AI825934 NM_020241 AB022433 AI936745 CA430435 AW054434 AF216389 CA433483 
    AF293363 BQ185898 AY358939 BE302795 NM_133327 AL525897 BG475468 AI825930 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SEMA6B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACGTGGCT
    SEMA6B Expression
    About this image

    SEMA6B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEMA6B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.465642
        Custom PCR Arrays for SEMA6B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA6B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SEMA6B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sema6b1 , 5 sema domain, transmembrane domain (TM), and cytoplasmic more1, 5 82.79(n)1
    89.92(a)1
      17 (29.17 cM)5
    203591  NM_013662.21  NP_038690.11 
     561230855 
    chicken
    (Gallus gallus)
    Aves SEMA6B1 sema domain, transmembrane domain (TM), and cytoplasmic more 72.36(n)
    70.98(a)
      428330  XM_004948805.1  XP_004948862.1 
    lizard
    (Anolis carolinensis)
    Reptilia SEMA6B6
    sema domain, transmembrane domain (TM), and cytopl...
    76(a)
    1 ↔ 1
    GL344270.1(963-16808)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sema6b1 sema domain, transmembrane domain (TM), and cytoplasmic more 62.68(n)
    66.92(a)
      100487068  XM_002942203.2  XP_002942249.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001488831 semaphorin 6bb 62.17(n)
    60.7(a)
      100148883  XM_002663110.2  XP_002663156.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sema-1a3 axon guidance 39(a)
    (best of 3)
        --


    ENSEMBL Gene Tree for SEMA6B (if available)
    TreeFam Gene Tree for SEMA6B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SEMA6B gene
    SEMA6D2  SEMA6C2  SEMA5A2  SEMA6A2  SEMA7A2  SEMA5B2  
    4 SIMAP similar genes for SEMA6B using alignment to 2 protein entries:     SEM6B_HUMAN (see all proteins):
    SEMA6D    SEMA6A    SEMA6C    SEMA5B

    SEMA6B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SEMA6B (see all 541)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2014243791,2
    --4542116(+) CTCAA-/AAAAAG
            
    AAAAA
    1 -- ds50010--------
    rs349314551,2
    C--4542245(+) TTTTTT/-GAGAC 1 -- ds50011Minor allele frequency- -:0.50NA 2
    rs1411655221,2
    C--4542254(+) ACAGCG/TTCTCG 1 -- ds50010--------
    rs1884517861,2
    --4542299(+) CTCAGC/TTCACT 1 -- ds50010--------
    rs1386778901,2
    --4542353(+) CGGCCC/GAGTAG 1 -- ds50010--------
    rs1488637991,2
    C--4542417(+) AGAGAC/TGGGGT 1 -- ds50010--------
    rs1912432081,2
    --4542496(+) AGTGCC/TGGGAT 1 -- ds50010--------
    rs1435078551,2
    --4542715(+) TCAGAA/GGGGGG 1 -- ut310--------
    rs1490720271,2
    C--4542916(+) AGAGT-/GGGGGG 1 -- ut310--------
    rs782376911,2
    C--4543048(+) GCACGC/TGTGGC 1 -- ut311Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for SEMA6B (4542600 - 4559820 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SEMA6B (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv614e199CNV Deletion23128226
    nsv2394CNV Loss18451855
    nsv428361CNV Loss18775914
    dgv3674n71CNV Loss21882294
    nsv910843CNV Loss21882294
    dgv3678n71CNV Loss21882294
    nsv910842CNV Loss21882294
    dgv3676n71CNV Loss21882294
    nsv910844CNV Loss21882294
    nsv828405CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SEMA6B
    DNA2.0 Custom Variant and Variant Library Synthesis for SEMA6B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608873    OMIM disorders: --

    2 diseases for SEMA6B:    About MalaCards
    periodontitis    breast cancer


    SEMA6B for disorders           About GeneDecksing


    Export disorders for SEMA6B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SEMA6B gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with SEMA6B)
        Utopia: connect your pdf to the dynamic
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    1. Human semaphorin 6b [(HSA)SEMA6B], a novel human class 6 semaphorin gene: alternative splicing and all-trans-retinoic acid-dependent downregulation in glioblastoma cell lines. (PubMed id 11350127)1, 2, 9 Correa R.G....Simpson A.J.G. (Genomics 2001)
    2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. The role of axon guidance factor semaphorin 6B in the invasion and metastasis of gastric cancer. (PubMed id 23781008)1 Ge C....Xu X. (J. Int. Med. Res. 2013)
    5. Analysis of SEMA6B gene expression in breast cancer: identification of a new isoform. (PubMed id 23665584)1 D'Apice L....De Berardinis P. (Biochim. Biophys. Acta 2013)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. The human semaphorin 6B gene is down regulated by PPARs. (PubMed id 15177567)1 Collet P....DauAsa M. (Genomics 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10501 HGNC: 10739 AceView: SEMA6B Ensembl:ENSG00000167680 euGenes: HUgn10501
    ECgene: SEMA6B Kegg: 10501 H-InvDB: SEMA6B

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SEMA6B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SEMA6B gene:
    Search GeneIP for patents involving SEMA6B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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