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GIFtS

SEMA6A Gene

protein-coding   GIFtS: 62
GCID: GC05M115807

sema domain, transmembrane domain (TM), and cytoplasmic...


(Previous symbol: SEMAQ)
 Explore 10 diseases affiliated with
SEMA6A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SEMA6A    

Aliases
for SEMA6A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sema Domain, Transmembrane Domain (TM), And Cytoplasmic Domain, (Semaphorin)
6A1 2
     Semaphorin VIA2 3
SEMAQ1 2 3     SEMA6A-12 3
HT0181 2     VIA2
SEMA1 2     Semaphorin 6A-12
SEMA6A11 2     Semaphorin-6A1
KIAA13681 3     Semaphorin-6A-13
Sema VIA2 3     Semaphorin-6A-13

External Ids:    HGNC: 107381   Entrez Gene: 575562   Ensembl: ENSG000000924217   OMIM: 6058855   UniProtKB: Q9H2E63   

Export aliases for SEMA6A gene to outside databases

Previous GC identifers: GC05M115548 GC05M116186 GC05M115810 GC05M115855 GC05M115858 GC05M110960


Summaries
for SEMA6A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SEMA6A:
The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of
the thalamocortical projection (Leighton et al., 2001 (PubMed 11242070)).(supplied by OMIM, Feb 2011)

UniProtKB/Swiss-Prot: SEM6A_HUMAN, Q9H2E6
Function: Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal
granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an
important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has
repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the
sympathetic chains and controlling the temporal sequence of sympathetic target innervation (By similarity)

Gene Wiki entry for SEMA6A


Genomic Views
for SEMA6A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEMA6A gene promoter:
         HOXA9B   HOXA9   Sox5   Meis-1b   POU2F1   FOXO4   POU2F1a   Zic1   Pax-4a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SEMA6A promoter sequence
   Search SABiosciences Chromatin IP Primers for SEMA6A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA6A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.1   Ensembl cytogenetic band:  5q23.1   HGNC cytogenetic band: 5q23

SEMA6A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA6A gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M115807:  view genomic region     (about GC identifiers)

Start:
 115,779,251 bp from pter      End:
 115,910,630 bp from pter
Size:
 131,380 bases      Orientation:
 minus strand

Proteins
for SEMA6A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SEM6A_HUMAN, Q9H2E6 (See protein sequence)
Recommended Name: Semaphorin-6A precursor  
Size: 1030 amino acids; 114395 Da
Subunit: Active as a homodimer or oligomer. The SEMA6A homodimer interacts with a PLXNA2 homodimer, giving rise to a
heterotetramer (By similarity). Interacts with EVL
Subcellular location: Cell membrane; Single-pass type I membrane protein
Sequence caution: Sequence=BAA92606.1; Type=Erroneous initiation;
Secondary accessions: Q9P2H9
Alternative splicing: 2 isoforms:  Q9H2E6-1   Q9H2E6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEMA6A: NX_Q9H2E6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H2E6

    • SEMA6A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065847.1  
    ENSEMBL proteins: 
     ENSP00000345512   ENSP00000257414   ENSP00000422997   ENSP00000422275   ENSP00000425364  
     ENSP00000424388   ENSP00000421935   ENSP00000425553   ENSP00000282394  
    Reactome Protein details: Q9H2E6
    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for SEMA6A (Semaphorin 6A)
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    OriGene Protein Over-expression Lysate: SEMA6A
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    Novus Biologicals SEMA6A Protein
    Novus Biologicals SEMA6A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SEMA6A

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane IEA--
    GO:0016021integral to membrane NAS10993894
    GO:0030424axon NAS10993894


    SEMA6A for ontologies           About GeneDecksing



    SEMA6A Antibody Products: 
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    Uscn ELISAs and CLIAs for SEMA6A

    Protein Domains /
    Families
    for SEMA6A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SEMA6A for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR003659 Plexin-like
     IPR002165 Plexin_repeat
     IPR016201 Plexin-like_fold
     IPR027231 Semaphorin
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9H2E6

    ProtoNet protein and cluster: Q9H2E6

    1 Blocks protein family: IPB001627 Semaphorin/CD100 antigen

    UniProtKB/Swiss-Prot: SEM6A_HUMAN, Q9H2E6
    Similarity: Belongs to the semaphorin family
    Similarity: Contains 1 PSI domain
    Similarity: Contains 1 Sema domain


    Function
    for SEMA6A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SEM6A_HUMAN, Q9H2E6
    Function: Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal
    granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an
    important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has
    repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the
    sympathetic chains and controlling the temporal sequence of sympathetic target innervation (By similarity)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SEMA6A
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA6A
    8/86 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA6A (see all 86):
    hsa-miR-323-3p hsa-miR-1258 hsa-miR-200a hsa-miR-128 hsa-miR-342-3p hsa-miR-4267 hsa-miR-489 hsa-miR-556-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA6A (see all 7)
    OriGene shRNA RFP: SEMA6A
    OriGene siRNA: SEMA6A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA6A

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SEMA6A

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA6A (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA6A
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SEMA6A (NM_020796)
    Sino Biological Human cDNA Clone for SEMA6A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA6A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA6A 

    Cell Line
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    Search LifeMap BioReagents cell lines for SEMA6A

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA6A

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0004888transmembrane signaling receptor activity IEA--
    GO:0005515protein binding IPI10993894
    GO:0030215semaphorin receptor binding IEA--


    SEMA6A for ontologies           About GeneDecksing


    Animal Models:
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sema6a):
     behavior/neurological  nervous system  reproductive system  vision/eye 

    SEMA6A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SEMA6A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Axon guidance
    		Axon guidance1.00
    		Developmental Biology0.69
    2Other semaphorin interactions
    		Other semaphorin interactions1.00
    3Axon guidance
    		Axon guidance1.00
    4Sema4D in semaphorin signaling
    		Semaphorin interactions0.44

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for SEMA6A
        Developmental Biology
    Semaphorin interactions
    Other semaphorin interactions
    Axon guidance


    1         Kegg Pathway  (Kegg details for SEMA6A):
        Axon guidance


    SEMA6A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEMA6A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/10 Interacting proteins for SEMA6A (Q9H2E63 ENSP000003455124) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EVLQ9UI083, ENSP000003766524I2D: score=2 STRING: ENSP00000376652
    PLXNA4Q9HCM23, ENSP000003231944I2D: score=1 STRING: ENSP00000323194
    ITSN2Q9NZM33, ENSP000003472444I2D: score=3 STRING: ENSP00000347244
    SH3RF1Q7Z6J03, ENSP000002846374I2D: score=3 STRING: ENSP00000284637
    SORBS1Q9BX663, ENSP000003551364I2D: score=3 STRING: ENSP00000355136
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0006915apoptotic process NAS10993894
    GO:0007010cytoskeleton organization NAS10993894
    GO:0007166cell surface receptor signaling pathway NAS10993894
    GO:0007275multicellular organismal development ----


    SEMA6A for ontologies           About GeneDecksing



    Drugs & Compounds
    for SEMA6A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEMA6A
    Search CenterWatch for drugs/clinical trials and news about SEMA6A / SEM6A 

    Transcripts
    for SEMA6A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SEMA6A gene: 
    NM_020796.3  

    Unigene Cluster for SEMA6A:

    Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
    Hs.156967  [show with all ESTs]
    Unigene Representative Sequence: BC032619
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343348(uc011cwe.2 uc003krv.4 uc003krw.4 uc010jcj.3 uc010jck.3 uc003krx.4)
    ENST00000257414 ENST00000513137 ENST00000515129 ENST00000503865 ENST00000510263
    ENST00000506114 ENST00000514316 ENST00000503402 ENST00000510024 ENST00000502996
    ENST00000503962 ENST00000515009 ENST00000509665 ENST00000512156 ENST00000282394


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA6A
    8/86 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA6A (see all 86):
    hsa-miR-323-3p hsa-miR-1258 hsa-miR-200a hsa-miR-128 hsa-miR-342-3p hsa-miR-4267 hsa-miR-489 hsa-miR-556-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA6A (see all 7)
    OriGene shRNA RFP: SEMA6A
    OriGene siRNA: SEMA6A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA6A
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA6A
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SEMA6A (NM_020796)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA6A 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA6A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA6A

    Additional cDNA sequence: 

    AB002438.1 AB002452.1 AB002453.1 AB037789.1 AF225425.1 AF279656.1 AK027439.1 AK027471.1 
    AK027501.1 AK027505.1 AK027654.1 AK027867.1 AK074975.1 AK096337.1 AK128648.1 AK302928.1 
    AK315143.1 BC032619.1 U06699.1 

    24 DOTS entries:

    DT.100774104  DT.100774107  DT.95374279  DT.100725200  DT.409557  DT.117145  DT.97818714  DT.100774105 
    DT.75116834  DT.120815079  DT.91752823  DT.100720332  DT.92436012  DT.100774109  DT.120815004  DT.120815089 
    DT.92017772  DT.95208744  DT.95360670  DT.102835852  DT.439164  DT.453545  DT.95131218  DT.97824836 

    24/282 AceView cDNA sequences (see all 282):

    F04878 BU738842 AK027439 BE265242 BI051117 AW103702 BQ024693 AL544905 
    BQ723018 BE275843 R23737 AK027501 AA461382 BM055373 Z39979 BE407695 
    AA682621 BU186963 BE500982 AA461202 AI123036 BM450002 N31614 AA699968 

    GeneLoc Exon Structure


    Expression
    for SEMA6A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEMA6A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGGGCAACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SEMA6A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainHypothalamusBrain
    BrainMedulla OblongataBrain
    BrainThalamusBrain
    HeartLeft VentricleHeart
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeDiencephalonNeural Tube
    Neural TubeMetencephalonNeural Tube
    Umbilical CordUmbilical VeinsUmbilical Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium

    See SEMA6A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEMA6A

    SOURCE GeneReport for Unigene cluster: Hs.156967
        SABiosciences Custom PCR Arrays for SEMA6A
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA6A

    Orthologs
    for SEMA6A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SEMA6A gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Sema6a1 , 5 sema domain, transmembrane domain (TM), and cytoplasmic more1, 5 89.97(n)1
    95.15(a)1    		   18 (25.08 cM)5
    203581  NM_018744.21  NP_061214.21 
     472355985 
    chicken
    (Gallus gallus)    		 Aves SEMA6A1 sema domain, transmembrane domain (TM), and cytoplasmic more 82.99(n)
    90.17(a)    		   427387  XM_003643072.1  XP_003643120.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SEMA6A6
    --
    		 --
    		 87(a)
    14(a)
    		 1 ↔ 1
    possible ortholog
    		 GL343193.1(8694677-8783152)
    GL343757.1(650-4500)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.162392 Xenopus laevis transcribed sequence with moderate similarity more 74.88(n)    CF290712.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufj46c122 wufj46c12 75.67(n)   336060  BC061707.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Sema-1b3 axon guidance 41(a)
    (best of 4)    		     --
    worm
    (Caenorhabditis elegans)    		 Secernentea mab-203 Expression: ray cell precursors, ventral
    nerve more    		 27(a)   I(1644872-1651256)   --


    ENSEMBL Gene Tree for SEMA6A (if available)
    TreeFam Gene Tree for SEMA6A (if available) 

    Paralogs
    for SEMA6A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEMA6A gene
    SEMA6D2  SEMA6B2  SEMA6C2  SEMA7A2  SEMA5A2  SEMA5B2  
    9 SIMAP similar genes for SEMA6A using alignment to 7 protein entries:     SEM6A_HUMAN (see all proteins):
    SEMA6B    SEMA6D    SEMA6C    SEMA4A    SEMA3A    SEMA4D
    SEMA3C    SEMA4F    SEMA3B

    SEMA6A for paralogs           About GeneDecksing



    Genomic Variants
    for SEMA6A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2656 NCBI SNPs in SEMA6A are shown (see all 2656)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1889021661,2
    		--115778789(+) ACAAGA/GAGTAA 1 -- ds50010--------
    rs1481077001,2
    		--115778809(+) CCCTCC/TACCTT 1 -- ds50010--------
    rs1156589591,2
    		--115778819(+) TATTAA/GTATGT 1 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1418508911,2
    		--115778849(+) CTGTGC/GAAGGA 1 -- ds50010--------
    rs174316891,2
    		C,F,H,--115778852(+) TGCAAG/TGATCT 1 -- ds500128Minor allele frequency- T:0.12NA NS EA CSA WA 3326
    rs1506057701,2
    		--115778971(+) ATGAAC/TAGAAG 1 -- ds50010--------
    rs1410305231,2
    		--115779007(+) ATTACC/TGGTGG 1 -- ds50010--------
    rs1448760041,2
    		--115779019(+) TTCTGC/TTAAAA 1 -- ds50010--------
    rs1475350261,2
    		--115779122(+) ATACCA/GTTATG 1 -- ds50010--------
    rs1401243191,2
    		--115779235(+) AAGCAA/TTCAGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SEMA6A (115779251 - 115910630 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for SEMA6A
         1 CNV: 99269
         6 Indels: 40796 62421 12743 46757 12742 43051

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for SEMA6A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SEMA6A for disorders           About GeneDecksing

    OMIM gene information: 605885    OMIM disorders: --

    10 diseases for SEMA6A:    About MalaCards
    ehlers-danlos syndrome    neuroaxonal dystrophy    amyotrophic lateral sclerosis    mouth disease
    lateral sclerosis    dysplasia of cervix    mucopolysaccharidosis    insulinoma
    colorectal cancer    neuronitis

    1 disease from the University of Copenhagen DISEASES database for SEMA6A:
    Mucopolysaccharidosis
    Human Genome Epidemiology (HuGE) Navigator: SEMA6A (2 documents)

    Export disorders for SEMA6A gene to outside databases

    Publications
    for SEMA6A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEMA6A gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with SEMA6A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A- 1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein- like protein (EVL) via a novel carboxyl-terminal zyxin-like domain. (PubMed id 10993894)1, 2, 3 Klostermann A.... Behl C. (2000)
    2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    3. Cloning and expression of a novel murine semaphorin with structural similarity to insect semaphorin I. (PubMed id 9204478)1, 3 Zhou L....Snider W.D. (1997)
    4. From plasma membrane to cytoskeleton: a novel function for semaphorin 6A. (PubMed id 18187809)1, 9 Prislei S....Ferlini C. (2008)
    5. The class 6 semaphorin SEMA6A is induced by interferon-gamma and defines an activation status of langerhans cells observed in pathological situations. (PubMed id 16436660)1, 9 Gautier G....Garrone P. (2006)
    6. MicroRNA-27a/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A. (PubMed id 22184411)1 Urbich C....Dimmeler S. (2012)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    8. A genome-wide meta-analysis of genetic variants associ ated with allergic rhinitis and grass sensitization and their interaction with b irth order. (PubMed id 22036096)1 Ramasamy A....Jarvis D.L. (2011)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    10. Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. (PubMed id 19451621)1 Landers J.E....Brown R.H. (2009)

    External Searches for SEMA6A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing SEMA6A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57556 HGNC: 10738 AceView: SEMA6A Ensembl:ENSG00000092421 euGenes: HUgn57556
    ECgene: SEMA6A Kegg: 57556 H-InvDB: SEMA6A

    Other Databases showing SEMA6A gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1368

    Specialized Databases showing SEMA6A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEMA6A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SEMA6A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SEMA6A gene:
    Search GeneIP for patents involving SEMA6A

    GeneCards and IP:
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