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Aliases for SEMA6A Gene

Aliases for SEMA6A Gene

  • Sema Domain, Transmembrane Domain (TM), And Cytoplasmic Domain, (Semaphorin) 6A 2 3
  • Semaphorin-6A-1 3 4
  • Semaphorin VIA 3 4
  • Sema VIa 2 3
  • SEMA6A-1 3 4
  • SEMAQ 3 4
  • Semaphorin 6A-1 3
  • Semaphorin-6A 3
  • KIAA1368 4
  • Sema VIA 4
  • SEMA6A1 3
  • HT018 3
  • SEMA 3
  • VIA 3

External Ids for SEMA6A Gene

Previous Symbols for SEMA6A Gene

  • SEMAQ

Summaries for SEMA6A Gene

Entrez Gene Summary for SEMA6A Gene

  • The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011]

GeneCards Summary for SEMA6A Gene

SEMA6A (Sema Domain, Transmembrane Domain (TM), And Cytoplasmic Domain, (Semaphorin) 6A) is a Protein Coding gene. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include transmembrane signaling receptor activity and semaphorin receptor binding. An important paralog of this gene is SEMA6C.

UniProtKB/Swiss-Prot for SEMA6A Gene

  • Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation (By similarity).

Gene Wiki entry for SEMA6A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMA6A Gene

Genomics for SEMA6A Gene

Genomic Location for SEMA6A Gene

Start:
116,443,555 bp from pter
End:
116,574,934 bp from pter
Size:
131,380 bases
Orientation:
Minus strand

Genomic View for SEMA6A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEMA6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA6A Gene

Regulatory Elements for SEMA6A Gene

Proteins for SEMA6A Gene

  • Protein details for SEMA6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2E6-SEM6A_HUMAN
    Recommended name:
    Semaphorin-6A
    Protein Accession:
    Q9H2E6
    Secondary Accessions:
    • Q9P2H9

    Protein attributes for SEMA6A Gene

    Size:
    1030 amino acids
    Molecular mass:
    114395 Da
    Quaternary structure:
    • Active as a homodimer or oligomer. The SEMA6A homodimer interacts with a PLXNA2 homodimer, giving rise to a heterotetramer (By similarity). Interacts with EVL.
    SequenceCaution:
    • Sequence=BAA92606.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SEMA6A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEMA6A Gene

Proteomics data for SEMA6A Gene at MOPED

Post-translational modifications for SEMA6A Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn33, Asn49, Asn65, Asn282, Asn434, and Asn461

Other Protein References for SEMA6A Gene

No data available for DME Specific Peptides for SEMA6A Gene

Domains for SEMA6A Gene

Gene Families for SEMA6A Gene

HGNC:

UniProtKB/Swiss-Prot:

SEM6A_HUMAN
Domain:
  • Contains 1 PSI domain.:
    • Q9H2E6
  • Contains 1 Sema domain.:
    • Q9H2E6
Family:
  • Belongs to the semaphorin family.:
    • Q9H2E6
genes like me logo Genes that share domains with SEMA6A: view

Function for SEMA6A Gene

Molecular function for SEMA6A Gene

UniProtKB/Swiss-Prot Function: Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation (By similarity).

Gene Ontology (GO) - Molecular Function for SEMA6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0004888 transmembrane signaling receptor activity --
GO:0005515 protein binding IPI 10993894
GO:0030215 semaphorin receptor binding --
genes like me logo Genes that share ontologies with SEMA6A: view
genes like me logo Genes that share phenotypes with SEMA6A: view

miRNA for SEMA6A Gene

miRTarBase miRNAs that target SEMA6A

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEMA6A Gene

Localization for SEMA6A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA6A Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEMA6A Gene COMPARTMENTS Subcellular localization image for SEMA6A gene
Compartment Confidence
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SEMA6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane --
GO:0016020 membrane --
GO:0016021 integral component of membrane NAS 10993894
GO:0030424 axon NAS 10993894
genes like me logo Genes that share ontologies with SEMA6A: view

Pathways for SEMA6A Gene

genes like me logo Genes that share pathways with SEMA6A: view

Pathways by source for SEMA6A Gene

1 BioSystems pathway for SEMA6A Gene
1 KEGG pathway for SEMA6A Gene

Gene Ontology (GO) - Biological Process for SEMA6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration --
GO:0006915 apoptotic process NAS 10993894
GO:0007010 cytoskeleton organization NAS 10993894
GO:0007166 cell surface receptor signaling pathway NAS 10993894
GO:0007275 multicellular organismal development --
genes like me logo Genes that share ontologies with SEMA6A: view

Transcripts for SEMA6A Gene

Unigene Clusters for SEMA6A Gene

Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA6A Gene

No ASD Table

Relevant External Links for SEMA6A Gene

GeneLoc Exon Structure for
SEMA6A
ECgene alternative splicing isoforms for
SEMA6A

Expression for SEMA6A Gene

mRNA expression in normal human tissues for SEMA6A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEMA6A Gene

This gene is overexpressed in Adrenal Gland (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SEMA6A Gene

SOURCE GeneReport for Unigene cluster for SEMA6A Gene Hs.156967

genes like me logo Genes that share expressions with SEMA6A: view

Orthologs for SEMA6A Gene

This gene was present in the common ancestor of animals.

Orthologs for SEMA6A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEMA6A 36
  • 99.61 (n)
  • 99.71 (a)
SEMA6A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SEMA6A 36
  • 91.04 (n)
  • 95.81 (a)
SEMA6A 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEMA6A 36
  • 92.3 (n)
  • 95.73 (a)
SEMA6A 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sema6a 36
  • 89.97 (n)
  • 95.15 (a)
Sema6a 16
Sema6a 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEMA6A 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEMA6A 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sema6a 36
  • 90.06 (n)
  • 94.37 (a)
chicken
(Gallus gallus)
Aves SEMA6A 36
  • 82.99 (n)
  • 90.17 (a)
SEMA6A 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEMA6A 37
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16239 36
tropical clawed frog
(Silurana tropicalis)
Amphibia sema6a 36
  • 74.86 (n)
  • 84.1 (a)
Str.2597 36
zebrafish
(Danio rerio)
Actinopterygii sema6a 36
  • 69.5 (n)
  • 73.16 (a)
sema6a 37
  • 72 (a)
OneToOne
wufj46c12 36
fruit fly
(Drosophila melanogaster)
Insecta Sema-2a 37
  • 29 (a)
ManyToMany
Sema-2b 37
  • 26 (a)
ManyToMany
Sema-1b 38
  • 41 (a)
Sema-1a 38
  • 35 (a)
Sema-2a 38
  • 33 (a)
CG4383 38
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea mab-20 38
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 29 (a)
OneToMany
Species with no ortholog for SEMA6A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEMA6A Gene

ENSEMBL:
Gene Tree for SEMA6A (if available)
TreeFam:
Gene Tree for SEMA6A (if available)

Paralogs for SEMA6A Gene

Paralogs for SEMA6A Gene

Selected SIMAP similar genes for SEMA6A Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SEMA6A: view

Variants for SEMA6A Gene

Sequence variations from dbSNP and Humsavar for SEMA6A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs27495 -- 116,479,988(-) AAATG(C/G)TGGCC intron-variant
rs28028 -- 116,481,211(+) GTGCT(A/G)GTATT intron-variant
rs28308 -- 116,479,639(+) CCCTT(C/T)GCTGT intron-variant
rs28309 -- 116,479,477(-) TACTA(C/T)GACTT intron-variant
rs32972 -- 116,495,396(-) TTGTC(A/G)GTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEMA6A Gene

Variant ID Type Subtype PubMed ID
nsv518494 CNV Loss 19592680
esv2549113 CNV Deletion 19546169
esv2061795 CNV Deletion 18987734
esv3227 CNV Deletion 18987735
esv2730635 CNV Deletion 23290073
dgv210n6 CNV Loss 16902084
esv5985 CNV Loss 19470904

Relevant External Links for SEMA6A Gene

HapMap Linkage Disequilibrium report
SEMA6A

Disorders for SEMA6A Gene

(1) University of Copenhagen DISEASES for SEMA6A Gene

Relevant External Links for SEMA6A

Genetic Association Database (GAD)
SEMA6A
Human Genome Epidemiology (HuGE) Navigator
SEMA6A
genes like me logo Genes that share disorders with SEMA6A: view

No data available for UniProtKB/Swiss-Prot for SEMA6A Gene

Publications for SEMA6A Gene

  1. The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A- 1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein- like protein (EVL) via a novel carboxyl-terminal zyxin-like domain. (PMID: 10993894) Klostermann A. … Behl C. (J. Biol. Chem. 2000) 2 3 4
  2. The class 6 semaphorin SEMA6A is induced by interferon-gamma and defines an activation status of langerhans cells observed in pathological situations. (PMID: 16436660) Gautier G. … Garrone P. (Am. J. Pathol. 2006) 3 23
  3. From plasma membrane to cytoskeleton: a novel function for semaphorin 6A. (PMID: 18187809) Prislei S. … Ferlini C. (Mol. Cancer Ther. 2008) 3 23
  4. Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. (PMID: 19451621) Landers J.E. … Brown R.H. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 49
  5. The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations. (PMID: 19578876) Johnson M.P. … Moses E.K. (Hum. Genet. 2009) 3 49

Products for SEMA6A Gene

Sources for SEMA6A Gene

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