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Aliases for SEMA6A Gene

Aliases for SEMA6A Gene

  • Semaphorin 6A 2 3
  • Sema Domain, Transmembrane Domain (TM), And Cytoplasmic Domain, (Semaphorin) 6A 2 3 5
  • Semaphorin-6A-1 3 4
  • Semaphorin VIA 3 4
  • Sema VIa 2 3
  • SEMA6A-1 3 4
  • SEMAQ 3 4
  • Semaphorin 6A-1 3
  • KIAA1368 4
  • Sema VIA 4
  • SEMA6A1 3
  • HT018 3
  • SemA 3
  • VIA 3

External Ids for SEMA6A Gene

Previous HGNC Symbols for SEMA6A Gene

  • SEMAQ

Previous GeneCards Identifiers for SEMA6A Gene

  • GC05M115548
  • GC05M116186
  • GC05M115810
  • GC05M115855
  • GC05M115858
  • GC05M115807
  • GC05M110960

Summaries for SEMA6A Gene

Entrez Gene Summary for SEMA6A Gene

  • The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011]

GeneCards Summary for SEMA6A Gene

SEMA6A (Semaphorin 6A) is a Protein Coding gene. Among its related pathways are Developmental Biology and Axon guidance. GO annotations related to this gene include receptor activity and semaphorin receptor binding. An important paralog of this gene is SEMA6C.

UniProtKB/Swiss-Prot for SEMA6A Gene

  • Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation (By similarity).

Gene Wiki entry for SEMA6A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMA6A Gene

Genomics for SEMA6A Gene

Regulatory Elements for SEMA6A Gene

Promoters for SEMA6A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SEMA6A on UCSC Golden Path with GeneCards custom track

Genomic Location for SEMA6A Gene

Chromosome:
5
Start:
116,443,555 bp from pter
End:
116,574,934 bp from pter
Size:
131,380 bases
Orientation:
Minus strand

Genomic View for SEMA6A Gene

Genes around SEMA6A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEMA6A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEMA6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA6A Gene

Proteins for SEMA6A Gene

  • Protein details for SEMA6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2E6-SEM6A_HUMAN
    Recommended name:
    Semaphorin-6A
    Protein Accession:
    Q9H2E6
    Secondary Accessions:
    • Q9P2H9

    Protein attributes for SEMA6A Gene

    Size:
    1030 amino acids
    Molecular mass:
    114395 Da
    Quaternary structure:
    • Active as a homodimer or oligomer. The SEMA6A homodimer interacts with a PLXNA2 homodimer, giving rise to a heterotetramer (By similarity). Interacts with EVL.
    SequenceCaution:
    • Sequence=BAA92606.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SEMA6A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEMA6A Gene

Proteomics data for SEMA6A Gene at MOPED

Post-translational modifications for SEMA6A Gene

  • Glycosylation at Asn 33, Asn 49, Asn 65, Asn 282, Asn 434, and Asn 461
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for SEMA6A (Semaphorin 6A)

No data available for DME Specific Peptides for SEMA6A Gene

Domains & Families for SEMA6A Gene

Gene Families for SEMA6A Gene

Suggested Antigen Peptide Sequences for SEMA6A Gene

Graphical View of Domain Structure for InterPro Entry

Q9H2E6

UniProtKB/Swiss-Prot:

SEM6A_HUMAN :
  • Contains 1 PSI domain.
  • Belongs to the semaphorin family.
Domain:
  • Contains 1 PSI domain.
  • Contains 1 Sema domain.
Family:
  • Belongs to the semaphorin family.
genes like me logo Genes that share domains with SEMA6A: view

Function for SEMA6A Gene

Molecular function for SEMA6A Gene

UniProtKB/Swiss-Prot Function:
Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation (By similarity).

Gene Ontology (GO) - Molecular Function for SEMA6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
genes like me logo Genes that share ontologies with SEMA6A: view
genes like me logo Genes that share phenotypes with SEMA6A: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEMA6A Gene

Localization for SEMA6A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA6A Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEMA6A Gene COMPARTMENTS Subcellular localization image for SEMA6A gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SEMA6A Gene

Pathways & Interactions for SEMA6A Gene

genes like me logo Genes that share pathways with SEMA6A: view

Pathways by source for SEMA6A Gene

1 BioSystems pathway for SEMA6A Gene
1 KEGG pathway for SEMA6A Gene

Gene Ontology (GO) - Biological Process for SEMA6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001755 neural crest cell migration IBA --
GO:0006915 apoptotic process NAS 10993894
GO:0007010 cytoskeleton organization NAS 10993894
GO:0007166 cell surface receptor signaling pathway NAS 10993894
GO:0007399 nervous system development NAS 10993894
genes like me logo Genes that share ontologies with SEMA6A: view

No data available for SIGNOR curated interactions for SEMA6A Gene

Drugs & Compounds for SEMA6A Gene

No Compound Related Data Available

Transcripts for SEMA6A Gene

Unigene Clusters for SEMA6A Gene

Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA6A Gene

No ASD Table

Relevant External Links for SEMA6A Gene

GeneLoc Exon Structure for
SEMA6A
ECgene alternative splicing isoforms for
SEMA6A

Expression for SEMA6A Gene

mRNA expression in normal human tissues for SEMA6A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEMA6A Gene

This gene is overexpressed in Adrenal Gland (x5.0).

Protein differential expression in normal tissues from HIPED for SEMA6A Gene

This gene is overexpressed in Vitreous humor (57.6) and Peripheral blood mononuclear cells (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SEMA6A Gene



SOURCE GeneReport for Unigene cluster for SEMA6A Gene Hs.156967

genes like me logo Genes that share expression patterns with SEMA6A: view

Protein tissue co-expression partners for SEMA6A Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SEMA6A Gene

Orthologs for SEMA6A Gene

This gene was present in the common ancestor of animals.

Orthologs for SEMA6A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEMA6A 36
  • 100 (a)
OneToOne
SEMA6A 35
  • 99.61 (n)
  • 99.71 (a)
cow
(Bos Taurus)
Mammalia SEMA6A 35
  • 91.04 (n)
  • 95.81 (a)
SEMA6A 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEMA6A 36
  • 96 (a)
OneToOne
SEMA6A 35
  • 92.3 (n)
  • 95.73 (a)
mouse
(Mus musculus)
Mammalia Sema6a 16
Sema6a 35
  • 89.97 (n)
  • 95.15 (a)
Sema6a 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEMA6A 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEMA6A 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sema6a 35
  • 90.06 (n)
  • 94.37 (a)
chicken
(Gallus gallus)
Aves SEMA6A 35
  • 82.99 (n)
  • 90.17 (a)
SEMA6A 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEMA6A 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16239 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sema6a 35
  • 74.86 (n)
  • 84.1 (a)
Str.2597 35
zebrafish
(Danio rerio)
Actinopterygii sema6a 35
  • 69.5 (n)
  • 73.16 (a)
wufj46c12 35
sema6a 36
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4383 37
  • 35 (a)
Sema-1a 37
  • 35 (a)
Sema-1b 37
  • 41 (a)
Sema-2a 37
  • 33 (a)
Sema-2a 36
  • 29 (a)
ManyToMany
Sema-2b 36
  • 26 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea mab-20 37
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToMany
Species with no ortholog for SEMA6A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEMA6A Gene

ENSEMBL:
Gene Tree for SEMA6A (if available)
TreeFam:
Gene Tree for SEMA6A (if available)

Paralogs for SEMA6A Gene

Paralogs for SEMA6A Gene

genes like me logo Genes that share paralogs with SEMA6A: view

Variants for SEMA6A Gene

Sequence variations from dbSNP and Humsavar for SEMA6A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs34966 - 116,478,030(-) AACGA(C/T)ATGGG reference, missense
rs17432496 - 116,475,577(+) TGCCA(C/T)GCTCT reference, missense
rs12516652 - 116,475,552(+) TGACA(G/T)TCCCC reference, missense
rs28308 -- 116,479,639(+) CCCTT(C/T)GCTGT intron-variant
rs28309 -- 116,479,477(-) TACTA(C/T)GACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEMA6A Gene

Variant ID Type Subtype PubMed ID
nsv518494 CNV Loss 19592680
esv2549113 CNV Deletion 19546169
esv2061795 CNV Deletion 18987734
esv3227 CNV Deletion 18987735
esv2730635 CNV Deletion 23290073
dgv210n6 CNV Loss 16902084
esv5985 CNV Loss 19470904

Variation tolerance for SEMA6A Gene

Residual Variation Intolerance Score: 9.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.46; 64.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEMA6A Gene

HapMap Linkage Disequilibrium report
SEMA6A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEMA6A Gene

Disorders for SEMA6A Gene

Relevant External Links for SEMA6A

Genetic Association Database (GAD)
SEMA6A
Human Genome Epidemiology (HuGE) Navigator
SEMA6A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEMA6A

No disorders were found for SEMA6A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEMA6A Gene

Publications for SEMA6A Gene

  1. The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A- 1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein- like protein (EVL) via a novel carboxyl-terminal zyxin-like domain. (PMID: 10993894) Klostermann A. … Behl C. (J. Biol. Chem. 2000) 2 3 4 67
  2. From plasma membrane to cytoskeleton: a novel function for semaphorin 6A. (PMID: 18187809) Prislei S. … Ferlini C. (Mol. Cancer Ther. 2008) 3 23
  3. The class 6 semaphorin SEMA6A is induced by interferon-gamma and defines an activation status of langerhans cells observed in pathological situations. (PMID: 16436660) Gautier G. … Garrone P. (Am. J. Pathol. 2006) 3 23
  4. Cloning and expression of a novel murine semaphorin with structural similarity to insect semaphorin I. (PMID: 9204478) Zhou L. … Snider W.D. (Mol. Cell. Neurosci. 1997) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for SEMA6A Gene

Sources for SEMA6A Gene

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