Aliases for SEMA6A Gene
External Ids for SEMA6A Gene
Previous HGNC Symbols for SEMA6A Gene
Previous GeneCards Identifiers for SEMA6A Gene
The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011]
GeneCards Summary for SEMA6A Gene
SEMA6A (Sema Domain, Transmembrane Domain (TM), And Cytoplasmic Domain, (Semaphorin) 6A) is a Protein Coding gene. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include transmembrane signaling receptor activity and semaphorin receptor binding. An important paralog of this gene is SEMA6C.
UniProtKB/Swiss-Prot for SEMA6A Gene
Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation (By similarity).