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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEMA5B Gene

protein-coding   GIFtS: 55
GCID: GC03M122628

Sema Domain, Seven Thrombospondin Repeats (Type 1 And Type...


(Previous symbol: SEMAG)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sema Domain, Seven Thrombospondin Repeats (Type 1 And Type 1-Like),
Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin)
5B1 2
SEMAG1 2 3
SemG2
semaphorin-5B2
KIAA14453

External Ids:    HGNC: 107371   Entrez Gene: 544372   Ensembl: ENSG000000826847   OMIM: 6092985   UniProtKB: Q9P2833   

Export aliases for SEMA5B gene to outside databases

Previous GC identifers: GC03M119346 GC03M122576 GC03M123909 GC03M123948 GC03M124110 GC03M120001


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEMA5B Gene:
This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the
nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which
semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The
protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for SEMA5B Gene: 
SEMA5B (sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B) is a protein-coding gene. Diseases associated with SEMA5B include clear cell renal cell carcinoma, and cerebral palsy. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA6D.

UniProtKB/Swiss-Prot: SEM5B_HUMAN, Q9P283
Function: May act as positive axonal guidance cues (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEMA5B gene promoter:
         NRSF form 1   Pax-2   Pax-2a   NRSF form 2   POU2F1   POU2F1a   Chx10   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SEMA5B promoter sequence
   Search SABiosciences Chromatin IP Primers for SEMA5B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.1   Ensembl cytogenetic band:  3q21.1   HGNC cytogenetic band: 3q21.1

SEMA5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA5B gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M122628:  view genomic region     (about GC identifiers)

Start:
122,628,041 bp from pter      End:
122,747,452 bp from pter
Size:
119,412 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SEM5B_HUMAN, Q9P283 (See protein sequence)
Recommended Name: Semaphorin-5B  
Size: 1151 amino acids; 125913 Da
Subcellular location: Membrane; Single-pass type III membrane protein
Caution: It is uncertain whether Met-1 or Met-59 is the initiator
Sequence caution: Sequence=BAA91570.1; Type=Erroneous initiation; Sequence=BAA95969.1; Type=Erroneous initiation;
Secondary accessions: A8K5U2 B7Z393 F8W9U8 Q6DD89 Q6UY12 Q9NW17
Alternative splicing: 4 isoforms:  Q9P283-1   Q9P283-2   Q9P283-3   Q9P283-4   (No experimental confirmation available. Ref.3 (BAH12129) sequence is in conflict in position: 14:R->K)

Explore the universe of human proteins at neXtProt for SEMA5B: NX_Q9P283

Explore proteomics data for SEMA5B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P283

  • SEMA5B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SEMA5B Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001026872.2  NP_001243275.1  NP_001243276.1  NP_001243277.1  

    ENSEMBL proteins: 
     ENSP00000400828   ENSP00000350215   ENSP00000417570   ENSP00000377208   ENSP00000401056  
     ENSP00000401038   ENSP00000389588   ENSP00000195173  

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    Cloud-Clone Corp. Proteins for SEMA5B 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    SEMA5B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SEMA: Semaphorins

    5/7 InterPro protein domains (see all 7):
     IPR000884 Thrombospondin_1_rpt
     IPR003659 Plexin-like
     IPR002165 Plexin_repeat
     IPR016201 Plexin-like_fold
     IPR027231 Semaphorin

    Graphical View of Domain Structure for InterPro Entry Q9P283

    ProtoNet protein and cluster: Q9P283

    1 Blocks protein domain: IPB000884 Thrombospondin

    UniProtKB/Swiss-Prot: SEM5B_HUMAN, Q9P283
    Similarity: Belongs to the semaphorin family
    Similarity: Contains 1 PSI domain
    Similarity: Contains 1 Sema domain
    Similarity: Contains 5 TSP type-1 domains


    SEMA5B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEM5B_HUMAN, Q9P283
    Function: May act as positive axonal guidance cues (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----
         
    SEMA5B for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Sema5b):
     behavior/neurological  hematopoietic system  homeostasis/metabolism  immune system  nervous system 
     no phenotypic analysis  vision/eye 

    SEMA5B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sema5btm1.2Alk for SEMA5B

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SEMA5B 
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    SwitchGear 3'UTR luciferase reporter plasmidSEMA5B 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA5B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SEMA5B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Axon guidance

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for SEMA5B):
        Axon guidance


    SEMA5B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEMA5B

    5/9 Interacting proteins for SEMA5B (Q9P2832, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271498 I2D: score=2 
    SMN2Q166372, 3MINT-8271498 I2D: score=2 
    ANXA7P200732, 3MINT-8248702 I2D: score=2 
    C11orf58O001932, 3MINT-8249876 I2D: score=2 
    FAM118BQ9BPY32, 3MINT-8255200 I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development ----
    GO:0007399nervous system development IEA--
    GO:0030154cell differentiation IEA--

    SEMA5B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEMA5B (SEM5B)

    Search CenterWatch for drugs/clinical trials and news about SEMA5B / SEM5B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SEMA5B gene (5 alternative transcripts): 
    NM_018987.1  NM_001031702.3  NM_001256346.1  NM_001256347.1  NM_001256348.1  

    Unigene Cluster for SEMA5B:

    Sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
    Hs.210870  [show with all ESTs]
    Unigene Representative Sequence: NM_001256346
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000451541(uc003efy.1) ENST00000357599(uc003efz.1 uc011bju.1 uc010hro.1 uc010hrp.1)
    ENST00000475244(uc003ega.1) ENST00000393583(uc003egb.1) ENST00000465147
    ENST00000421053 ENST00000477001 ENST00000449546 ENST00000451055 ENST00000195173

    miRNA
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    hsa-miR-3194-5p hsa-miR-631 hsa-miR-15a hsa-miR-29a hsa-miR-29c hsa-miR-486-3p hsa-miR-3661 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidSEMA5B 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB040878.1 AK001234.1 AK091481.1 AK291407.1 AK294528.1 AK295619.1 AK309834.1 AK309848.1 
    BC002776.2 BC077726.1 NR_046079.1 

    6 DOTS entries:

    DT.75100789  DT.101980637  DT.92016969  DT.92422031  DT.92422033  DT.100662283 

    24/53 AceView cDNA sequences (see all 53):

    AI479935 CR593104 AK091481 AA862794 BC002776 BE301167 AK001234 BM713996 
    CB045671 BG422528 AA045047 BM701601 BF527649 BF436238 AI371424 BM721339 
    BE044353 BF345903 BQ882487 BQ012509 AA026150 BF529151 AU124266 BF037176 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SEMA5B (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^
    SP1:        -     -     -     -     -     -                                                                       -                                             
    SP2:                          -     -     -                                                                       -                                             
    SP3:                                      -                                                                       -                                             
    SP4:                          -     -     -     -                 -     -                                                                                       
    SP5:                                -     -                                                                                                                     

    ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b · 26c ^ 27a · 27b
    SP1:                                            -                           
    SP2:                                      -     -                           
    SP3:                                      -     -                           
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for SEMA5B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEMA5B expression in normal human tissues (normalized intensities)      SEMA5B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGACCAAGGC
    SEMA5B Expression
    About this image


    SEMA5B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Postnatal Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             bronchus ; respiratory epithelial cells   
     
     Epithelium (Uncategorized)    fully expand to see all 2 entries
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Blood Brain Barrier (Nervous System)
             Postnatal Endothelial Cells Blood Brain Barrier

    See SEMA5B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEMA5B

    SOURCE GeneReport for Unigene cluster: Hs.210870
        SABiosciences Custom PCR Arrays for SEMA5B
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA5B
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA5B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SEMA5B gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sema5b1 , 5 sema domain, seven thrombospondin repeats (type 1 and more1, 5 89.08(n)1
    93.6(a)1
      16 (25.37 cM)5
    203571  NM_013661.21  NP_038689.21 
     355411455 
    chicken
    (Gallus gallus)
    Aves SEMA5B1 sema domain, seven thrombospondin repeats (type 1 and more 71.67(n)
    78.02(a)
      424248  XM_422096.2  XP_422096.2 
    lizard
    (Anolis carolinensis)
    Reptilia SEMA5B6
    Uncharacterized protein
    78(a)
    1 ↔ 1
    1(83129175-83269448)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC688352 hypothetical protein MGC68835 78.35(n)    BC059288.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sema5b1 sema domain, seven thrombospondin repeats (type 1 and more 66.42(n)
    67.78(a)
      556471  XM_679287.2  XP_684379.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sema-1a3
    Sema-5c1
    axon guidance3
    Semaphorin-5c1
    40(a)
    (best of 5)3
    50.96(n)1
    42.73(a)1
      370661  NM_137449.21  NP_611293.31 


    ENSEMBL Gene Tree for SEMA5B (if available)
    TreeFam Gene Tree for SEMA5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEMA5B gene
    SEMA6D2  SEMA6B2  SEMA6C2  SEMA5A2  SEMA6A2  SEMA7A2  
    11 SIMAP similar genes for SEMA5B using alignment to 7 protein entries:     SEM5B_HUMAN (see all proteins):
    SEMA5A    SEMA6C    SEMA3A    SEMA4A    SEMA3C    SEMA4B
    SEMA6D    SEMA6B    SEMA3F    SEMA4D    SEMA4C

    SEMA5B for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SEMA5B
    PGOHUM00000258303 PGOHUM00000258307


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2814 SNPs in SEMA5B are shown (see all 2814)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0371964
    A breast cancer sample4--see VAR_0371962 G S mis40--------
    VAR_0371984
    A breast cancer sample4--see VAR_0371982 I M mis40--------
    rs1924293131,2
    --122627704(+) CATCAA/GCACTC 5 -- ds50010--------
    rs1138362931,2
    C,F--122627877(+) ACACTG/CTATGT 5 -- ds50012Minor allele frequency- C:0.09NA 122
    rs1833803181,2
    --122627904(+) AATGGA/TAAGAT 5 -- ds50010--------
    rs1404058671,2
    --122627929(+) ATAAGG/TCTACT 5 -- ds50010--------
    rs1444063741,2
    --122627950(+) CCCCCA/GCCTTG 5 -- ds50010--------
    rs1478345581,2
    C--122627976(+) CCCTGA/GTGCAT 5 -- ds50010--------
    rs1878424851,2
    --122628051(+) TGGATA/GTCATC 5 -- ut31 nc-transcript-variant0--------
    rs803539161,2
    C,F--122628071(+) TAATGC/TCACAG 5 -- ut31 nc-transcript-variant2Minor allele frequency- T:0.04NA EA 240

    HapMap Linkage Disequilibrium report for SEMA5B (122628041 - 122747452 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SEMA5B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2678374CNV Deletion23128226
    esv998863CNV Insertion20482838
    nsv460836CNV Loss19166990
    nsv517695CNV Loss19592680
    nsv460835CNV Gain19166990
    nsv829706CNV Gain17160897
    nsv877393CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609298    OMIM disorders: --

    8 diseases for SEMA5B:    About MalaCards
    clear cell renal cell carcinoma    cerebral palsy    renal cell carcinoma    esophageal squamous cell carcinoma
    cerebritis    esophagitis    squamous cell carcinoma    neuronitis


    SEMA5B for disorders           About GeneDecksing

    Genetic Association Database (GAD): SEMA5B
    Human Genome Epidemiology (HuGE) Navigator: SEMA5B (4 documents)

    Export disorders for SEMA5B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEMA5B gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with SEMA5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies three new su sceptibility loci for esophageal squamous-cell carcinoma in Chinese populations . (PubMed id 21642993)1, 4 Wu C....Lin D. (2011)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
    7. A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis. (PubMed id 8817451)1, 3 Adams R.H....Puschel A.W. (1996)
    8. Semaphorin 5B mediates synapse elimination in hippoca mpal neurons. (PubMed id 19463192)1, 9 O'Connor T.P....Bamji S.X. (2009)
    9. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    10. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54437 HGNC: 10737 AceView: SEMA5B Ensembl:ENSG00000082684 euGenes: HUgn54437
    ECgene: SEMA5B Kegg: 54437 H-InvDB: SEMA5B

    (According to HUGE)
    About This Section
    HUGE: KIAA1445

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEMA5B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEMA5B gene:
    Search GeneIP for patents involving SEMA5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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