Aliases for SEMA5B Gene
External Ids for SEMA5B Gene
Previous HGNC Symbols for SEMA5B Gene
Previous GeneCards Identifiers for SEMA5B Gene
This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
GeneCards Summary for SEMA5B Gene
SEMA5B (Semaphorin 5B) is a Protein Coding gene. Among its related pathways are O-glycosylation of TSR domain-containing proteins and Diseases of glycosylation. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA5A.
UniProtKB/Swiss-Prot for SEMA5B Gene
May act as positive axonal guidance cues.