Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SEMA5B Gene

protein-coding   GIFtS: 57
GCID: GC03M122628

Sema Domain, Seven Thrombospondin Repeats (Type 1 And Type...


(Previous symbol: SEMAG)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Sema Domain, Seven Thrombospondin Repeats (Type 1 And Type 1-Like),
Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin)
5B1 2
SEMAG1 2 3
SemG2
semaphorin-5B2
KIAA14453

External Ids:    HGNC: 107371   Entrez Gene: 544372   Ensembl: ENSG000000826847   OMIM: 6092985   UniProtKB: Q9P2833   

Export aliases for SEMA5B gene to outside databases

Previous GC identifers: GC03M119346 GC03M122576 GC03M123909 GC03M123948 GC03M124110 GC03M120001


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SEMA5B Gene:
This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the
nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which
semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The
protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for SEMA5B Gene:
SEMA5B (sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B) is a protein-coding gene. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA6D.

UniProtKB/Swiss-Prot: SEM5B_HUMAN, Q9P283
Function: May act as positive axonal guidance cues (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEMA5B gene promoter:
         NRSF form 1   Pax-2   Pax-2a   NRSF form 2   POU2F1   POU2F1a   Chx10   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SEMA5B promoter sequence
   Search Chromatin IP Primers for SEMA5B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEMA5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.1   Ensembl cytogenetic band:  3q21.1   HGNC cytogenetic band: 3q21.1

SEMA5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA5B gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M122628:  view genomic region     (about GC identifiers)

Start:
122,628,041 bp from pter      End:
122,747,452 bp from pter
Size:
119,412 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SEM5B_HUMAN, Q9P283 (See protein sequence)
Recommended Name: Semaphorin-5B  
Size: 1151 amino acids; 125913 Da
Caution: It is uncertain whether Met-1 or Met-59 is the initiator
Sequence caution: Sequence=BAA91570.1; Type=Erroneous initiation; Sequence=BAA95969.1; Type=Erroneous initiation;
Secondary accessions: A8K5U2 B7Z393 F8W9U8 Q6DD89 Q6UY12 Q9NW17
Alternative splicing: 4 isoforms:  Q9P283-1   Q9P283-2   Q9P283-3   Q9P283-4   (No experimental confirmation available. Ref.3 (BAH12129) sequence is in conflict in position: 14:R->K)

Explore the universe of human proteins at neXtProt for SEMA5B: NX_Q9P283

Explore proteomics data for SEMA5B at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn153, Asn236, Asn345, Asn436, Thr788
  • Modification sites at PhosphoSitePlus

  • See SEMA5B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001026872.2  NP_001243275.1  NP_001243276.1  NP_001243277.1  

    ENSEMBL proteins: 
     ENSP00000400828   ENSP00000350215   ENSP00000417570   ENSP00000377208   ENSP00000401056  
     ENSP00000401038   ENSP00000389588   ENSP00000195173  
    Reactome Protein details: Q9P283

    SEMA5B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for SEMA5B (Semaphorin 5B)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SEMA5B
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SEMA5B
    GenScript Custom Purified and Recombinant Proteins Services for SEMA5B
    Novus Biologicals SEMA5B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEMA5B

     
    Search eBioscience for Proteins for SEMA5B 

    SEMA5B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SEMA5B
    Novus Biologicals SEMA5B Antibody
    Abcam antibodies for SEMA5B
    Cloud-Clone Corp. Antibodies for SEMA5B
    Search ThermoFisher Antibodies for SEMA5B
    Search LSBio for Antibodies for SEMA5B

    SEMA5B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SEMA5B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SEMA5B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SEMA5B
    Cloud-Clone Corp. CLIAs for SEMA5B
    Search eBioscience for ELISAs for SEMA5B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SEMA: Semaphorins

    Selected InterPro protein domains (see all 6):
     IPR000884 Thrombospondin_1_rpt
     IPR002165 Plexin_repeat
     IPR027231 Semaphorin
     IPR001627 Semap_dom
     IPR016201 Plexin-like_fold

    Graphical View of Domain Structure for InterPro Entry Q9P283

    ProtoNet protein and cluster: Q9P283

    1 Blocks protein domain: IPB000884 Thrombospondin

    UniProtKB/Swiss-Prot: SEM5B_HUMAN, Q9P283
    Similarity: Belongs to the semaphorin family
    Similarity: Contains 1 PSI domain
    Similarity: Contains 1 Sema domain
    Similarity: Contains 5 TSP type-1 domains


    Find genes that share domains with SEMA5B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEM5B_HUMAN, Q9P283
    Function: May act as positive axonal guidance cues (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SEMA5B           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Sema5b):
     behavior/neurological  hematopoietic system  homeostasis/metabolism  immune system  nervous system 
     no phenotypic analysis  vision/eye 

    Find genes that share phenotypes with SEMA5B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sema5btm1.2Alk for SEMA5B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEMA5B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SEMA5B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEMA5B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEMA5B

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SEMA5B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEMA5B (see all 22):
    hsa-miR-3194-5p hsa-miR-631 hsa-miR-15a hsa-miR-29a hsa-miR-29c hsa-miR-486-3p hsa-miR-3661 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidSEMA5B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SEMA5B
    Predesigned siRNA for gene silencing in human, mouse, rat SEMA5B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SEMA5B

    Clone
    Products:
         
    OriGene clones in human, mouse for SEMA5B (see all 7)
    OriGene ORF clones in mouse, rat for SEMA5B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEMA5B (NM_001031702)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA5B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA5B

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SEMA5B
    Browse ESI BIO Cell Lines and PureStem Progenitors for SEMA5B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA5B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SEM5B_HUMAN, Q9P283: Membrane; Single-pass type III membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol2
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SEMA5B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SEMA5B About    
    See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Axon guidance


    Find genes that share SuperPaths with SEMA5B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SEMA5B
        O-glycosylation of TSR domain-containing proteins


    1 Kegg Pathway  (Kegg details for SEMA5B):
        Axon guidance

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEMA5B
    Interactions:

        Search GeneGlobe Interaction Network for SEMA5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for SEMA5B (Q9P2832, 3 ENSP000003502154) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271498 I2D: score=2 
    SMN2Q166372, 3MINT-8271498 I2D: score=2 
    ANXA7P200732, 3MINT-8248702 I2D: score=2 
    C11orf58O001932, 3MINT-8249876 I2D: score=2 
    FAM118BQ9BPY32, 3MINT-8255200 I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development ----
    GO:0007399nervous system development IEA--
    GO:0030154cell differentiation IEA--

    Find genes that share ontologies with SEMA5B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEMA5B (SEM5B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SEMA5B gene (5 alternative transcripts): 
    NM_018987.1  NM_001031702.3  NM_001256346.1  NM_001256347.1  NM_001256348.1  

    Unigene Cluster for SEMA5B:

    Sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
    Hs.210870  [show with all ESTs]
    Unigene Representative Sequence: NM_001256346
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000451541(uc003efy.1) ENST00000357599(uc003efz.1 uc011bju.1 uc010hro.1 uc010hrp.1)
    ENST00000475244(uc003ega.1) ENST00000393583(uc003egb.1) ENST00000465147
    ENST00000421053 ENST00000477001 ENST00000449546 ENST00000451055 ENST00000195173

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SEMA5B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEMA5B (see all 22):
    hsa-miR-3194-5p hsa-miR-631 hsa-miR-15a hsa-miR-29a hsa-miR-29c hsa-miR-486-3p hsa-miR-3661 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidSEMA5B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SEMA5B
    Predesigned siRNA for gene silencing in human, mouse, rat SEMA5B
    Clone
    Products:
         
    OriGene clones in human, mouse for SEMA5B (see all 7)
    OriGene ORF clones in mouse, rat for SEMA5B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEMA5B (NM_001031702)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA5B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA5B
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SEMA5B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEMA5B
      QuantiTect SYBR Green Assays in human, mouse, rat SEMA5B
      QuantiFast Probe-based Assays in human, mouse, rat SEMA5B

    Additional mRNA sequence: 

    AB040878.1 AK001234.1 AK091481.1 AK291407.1 AK294528.1 AK295619.1 AK309834.1 AK309848.1 
    BC002776.2 BC077726.1 NR_046079.1 

    6 DOTS entries:

    DT.75100789  DT.101980637  DT.92016969  DT.92422031  DT.92422033  DT.100662283 

    Selected AceView cDNA sequences (see all 53):

    AK091481 AI479935 CR593104 AA862794 BC002776 BE301167 BM721339 BQ882487 
    BF436238 AI371424 BG325965 CB045671 BM701601 BF345903 AA045047 BF527649 
    BF529151 AU124266 BX419230 AA026150 AK001234 BQ012509 BG419769 AW149370 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SEMA5B (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^
    SP1:        -     -     -     -     -     -                                                                       -                                             
    SP2:                          -     -     -                                                                       -                                             
    SP3:                                      -                                                                       -                                             
    SP4:                          -     -     -     -                 -     -                                                                                       
    SP5:                                -     -                                                                                                                     

    ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b · 26c ^ 27a · 27b
    SP1:                                            -                           
    SP2:                                      -     -                           
    SP3:                                      -     -                           
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for SEMA5B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SEMA5B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGACCAAGGC
    SEMA5B Expression
    About this image


    SEMA5B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Mature Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Endothelium (Cardiovascular System)
             Mature Endothelial Cells Blood Brain Barrier
     
     Eye (Sensory Organs)
             Retina
    SEMA5B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEMA5B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.210870
        Custom PCR Arrays for SEMA5B
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SEMA5B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEMA5B
    QuantiTect SYBR Green Assays in human, mouse, rat SEMA5B
    QuantiFast Probe-based Assays in human, mouse, rat SEMA5B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA5B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SEMA5B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sema5b1 , 5 sema domain, seven thrombospondin repeats (type 1 and more1, 5 89.08(n)1
    93.6(a)1
      16 (25.37 cM)5
    203571  NM_013661.21  NP_038689.21 
     355411455 
    chicken
    (Gallus gallus)
    Aves SEMA5B1 sema domain, seven thrombospondin repeats (type 1 and more 71.99(n)
    78.52(a)
      424248  XM_422096.3  XP_422096.2 
    lizard
    (Anolis carolinensis)
    Reptilia SEMA5B6
    sema domain, seven thrombospondin repeats (type 1 ...
    78(a)
    1 ↔ 1
    1(83129175-83269448)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC688352 hypothetical protein MGC68835 78.35(n)    BC059288.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sema5ba1 sema domain, seven thrombospondin repeats (type 1 and more 67.4(n)
    69.18(a)
      556471  XM_679287.3  XP_684379.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sema-1a3
    Sema-5c1
    axon guidance3
    Semaphorin-5c1
    40(a)
    (best of 5)3
    51.04(n)1
    42.73(a)1
      370661  NM_137449.21  NP_611293.31 


    ENSEMBL Gene Tree for SEMA5B (if available)
    TreeFam Gene Tree for SEMA5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SEMA5B gene
    SEMA6D2  SEMA6B2  SEMA6C2  SEMA5A2  SEMA6A2  SEMA7A2  
    11 SIMAP similar genes for SEMA5B using alignment to 7 protein entries:     SEM5B_HUMAN (see all proteins):
    SEMA5A    SEMA6C    SEMA3A    SEMA4A    SEMA3C    SEMA4B
    SEMA6D    SEMA6B    SEMA3F    SEMA4D    SEMA4C

    Find genes that share paralogs with SEMA5B           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for SEMA5B
    PGOHUM00000258303 PGOHUM00000258307


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SEMA5B (see all 2814)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0371964
    A breast cancer sample4--see VAR_0371962 G S mis40--------
    VAR_0371984
    A breast cancer sample4--see VAR_0371982 I M mis40--------
    rs1924293131,2
    --122627704(+) CATCAA/GCACTC 5 -- ds50010--------
    rs1138362931,2
    C,F--122627877(+) ACACTG/CTATGT 5 -- ds50012Minor allele frequency- C:0.09NA 122
    rs1833803181,2
    --122627904(+) AATGGA/TAAGAT 5 -- ds50010--------
    rs1404058671,2
    --122627929(+) ATAAGG/TCTACT 5 -- ds50010--------
    rs1444063741,2
    --122627950(+) CCCCCA/GCCTTG 5 -- ds50010--------
    rs1478345581,2
    C--122627976(+) CCCTGA/GTGCAT 5 -- ds50010--------
    rs1878424851,2
    --122628051(+) TGGATA/GTCATC 5 -- ut31 nc-transcript-variant0--------
    rs803539161,2
    C,F--122628071(+) TAATGC/TCACAG 5 -- ut31 nc-transcript-variant2Minor allele frequency- T:0.04NA EA 240

    HapMap Linkage Disequilibrium report for SEMA5B (122628041 - 122747452 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SEMA5B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678374CNV Deletion23128226
    esv998863CNV Insertion20482838
    nsv460836CNV Loss19166990
    nsv517695CNV Loss19592680
    nsv460835CNV Gain19166990
    nsv829706CNV Gain17160897
    nsv877393CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEMA5B
    DNA2.0 Custom Variant and Variant Library Synthesis for SEMA5B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609298    OMIM disorders: --


    Find genes that share disorders with SEMA5B           About GenesLikeMe

    Genetic Association Database (GAD): SEMA5B
    Human Genome Epidemiology (HuGE) Navigator: SEMA5B (4 documents)

    Export disorders for SEMA5B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SEMA5B gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with SEMA5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. (PubMed id 21642993)1, 4 Wu C....Lin D. (Nat. Genet. 2011)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    7. A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis. (PubMed id 8817451)1, 3 Adams R.H....PA1schel A.W. (Mech. Dev. 1996)
    8. Semaphorin 5B mediates synapse elimination in hippocampal neurons. (PubMed id 19463192)1, 9 O'Connor T.P....Bamji S.X. (Neural Dev 2009)
    9. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    10. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 54437 HGNC: 10737 AceView: SEMA5B Ensembl:ENSG00000082684 euGenes: HUgn54437
    ECgene: SEMA5B Kegg: 54437 H-InvDB: SEMA5B

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1445

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SEMA5B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SEMA5B gene:
    Search GeneIP for patents involving SEMA5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for SEMA5B (Semaphorin 5B)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SEMA5B  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SEMA5B  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SEMA5B  
     OriGene qSTAR qPCR primer pairs in human, mouse for SEMA5B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SEMA5B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SEMA5B   OriGene Custom Protein Services for SEMA5B  

     
     
     Block miRNA regulation of human, mouse, rat SEMA5B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SEMA5B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEMA5B Predesigned siRNA for gene silencing in human, mouse, rat SEMA5B
     QuantiFast Probe-based Assays in human, mouse, rat SEMA5B QuantiTect SYBR Green Assays in human, mouse, rat SEMA5B
     Custom PCR Arrays for SEMA5B Search Chromatin IP Primers for SEMA5B
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEMA5B  Search GeneGlobe Interaction Network for SEMA5B
     Regulatory tfbs in SEMA5B promoter
     GenScript Custom Purified and Recombinant Proteins Services for SEMA5B GenScript cDNA clones with any tag delivered in your preferred vector for SEMA5B
     GenScript Custom Assay Services for SEMA5B GenScript Custom overexpressing Cell Line Services for SEMA5B
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SEMA5B (SEM5B)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SEMA5B antibodies
     SEMA5B lysates
     Antibodies for SEMA5B
     See all of Abcam's Antibodies, Kits and Proteins for SEMA5B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SEMA5B
     Antibodies for SEMA5B
     ELISAs for SEMA5B
     CLIAs for SEMA5B



     Browse ESI BIO Cell Lines and PureStem Progenitors for SEMA5B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA5B
     SwitchGear 3'UTR luciferase reporter plasmids for SEMA5B
     SwitchGear Promoter luciferase reporter plasmids for SEMA5B
     Search ThermoFisher Antibodies for SEMA5B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA5B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEMA5B
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SEMA5B
     Search LSBio for Antibodies for SEMA5B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for SEMA5B
      Search eBioscience for proteins for SEMA5B
      Search eBioscience for elisas for SEMA5B
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SEMA5B gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4