Aliases for SEMA5B Gene
External Ids for SEMA5B Gene
Previous HGNC Symbols for SEMA5B Gene
Previous GeneCards Identifiers for SEMA5B Gene
This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
GeneCards Summary for SEMA5B Gene
SEMA5B (Sema Domain, Seven Thrombospondin Repeats (Type 1 And Type 1-Like), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 5B) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Axon guidance. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA6C.
UniProtKB/Swiss-Prot for SEMA5B Gene
May act as positive axonal guidance cues.