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SEMA5B Gene

protein-coding GIFtS: 57
GCID: GC03M122628

Sema Domain, Seven Thrombospondin Repeats (Type 1 And Type...

(Previous symbol: SEMAG)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Sema Domain, Seven Thrombospondin Repeats (Type 1 And Type 1-Like), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 5B¹ ²
SEMAG¹ ² ³
SemG²
semaphorin-5B²
KIAA1445³

External Ids:	HGNC: 10737¹	Entrez Gene: 54437²	Ensembl: ENSG00000082684⁷	OMIM: 609298⁵	UniProtKB: Q9P283³

Export aliases for SEMA5B gene to outside databases

Previous GC identifers: GC03M119346 GC03M122576 GC03M123909 GC03M123948 GC03M124110 GC03M120001

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SEMA5B Gene:

This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the

nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which

semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The

protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants

encoding different isoforms have been found for this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for SEMA5B Gene:

SEMA5B (sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B) is a protein-coding gene. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA6D.

UniProtKB/Swiss-Prot: SEM5B_HUMAN, Q9P283

Function: May act as positive axonal guidance cues (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000003.11 NC_018914.2 NT_005612.17

Regulatory elements:

Regulatory transcription factor binding sites in the SEMA5B gene promoter:
NRSF form 1 Pax-2 Pax-2a NRSF form 2 POU2F1 POU2F1a Chx10 Ik-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SEMA5B promoter sequence

Search Chromatin IP Primers for SEMA5B

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEMA5B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.1 Ensembl cytogenetic band: 3q21.1 HGNC cytogenetic band: 3q21.1

SEMA5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA5B gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M122628: view genomic region (about GC identifiers)

Start:	122,628,041 bp from pter	End:	122,747,452 bp from pter
Size:	119,412 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SEM5B_HUMAN, Q9P283 (See protein sequence)

Recommended Name: Semaphorin-5B

Size: 1151 amino acids; 125913 Da

Caution: It is uncertain whether Met-1 or Met-59 is the initiator

Sequence caution: Sequence=BAA91570.1; Type=Erroneous initiation; Sequence=BAA95969.1; Type=Erroneous initiation;

Secondary accessions: A8K5U2 B7Z393 F8W9U8 Q6DD89 Q6UY12 Q9NW17

Alternative splicing: 4 isoforms: Q9P283-1 Q9P283-2 Q9P283-3 Q9P283-4 (No experimental confirmation available. Ref.3 (BAH12129) sequence is in conflict in position: 14:R->K)

Explore the universe of human proteins at neXtProt for SEMA5B: NX_Q9P283

Explore proteomics data for SEMA5B at MOPED

Post-translational modifications:

Glycosylation² at Asn153, Asn236, Asn345, Asn436, Thr788

Modification sites at PhosphoSitePlus

See SEMA5B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (4 alternative transcripts):

NP_001026872.2 NP_001243275.1 NP_001243276.1 NP_001243277.1

ENSEMBL proteins:

ENSP00000400828 ENSP00000350215 ENSP00000417570 ENSP00000377208 ENSP00000401056

ENSP00000401038 ENSP00000389588 ENSP00000195173

Reactome Protein details: Q9P283

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

SEMA: Semaphorins

Selected InterPro protein domains (see all 6):

IPR000884 Thrombospondin_1_rpt

IPR002165 Plexin_repeat

IPR027231 Semaphorin

IPR001627 Semap_dom

IPR016201 Plexin-like_fold

Graphical View of Domain Structure for InterPro Entry Q9P283

ProtoNet protein and cluster: Q9P283

1 Blocks protein domain: IPB000884 Thrombospondin

UniProtKB/Swiss-Prot: SEM5B_HUMAN, Q9P283

Similarity: Belongs to the semaphorin family

Similarity: Contains 1 PSI domain

Similarity: Contains 1 Sema domain

Similarity: Contains 5 TSP type-1 domains

Find genes that share domains with SEMA5B About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: SEM5B_HUMAN, Q9P283

Function: May act as positive axonal guidance cues (By similarity)

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0005515	protein binding	--	--

Find genes that share ontologies with SEMA5B About GenesLikeMe

Phenotypes:
7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Sema5b):

behavior/neurological	hematopoietic system	homeostasis/metabolism	immune system	nervous system
no phenotypic analysis	vision/eye

Find genes that share phenotypes with SEMA5B About GenesLikeMe

Animal Models:
MGI mouse knock-out Sema5b^tm1.2Alk for SEMA5B

genOway: Develop your customized and physiologically relevant rodent model for SEMA5B

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		Selected qRT-PCR Assays for microRNAs that regulate SEMA5B (see all 22):
		hsa-miR-3194-5p hsa-miR-631 hsa-miR-15a hsa-miR-29a hsa-miR-29c hsa-miR-486-3p hsa-miR-3661 hsa-miR-424

		SwitchGear 3'UTR luciferase reporter plasmid: SEMA5B 3' UTR sequence

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA5B

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

SEM5B_HUMAN, Q9P283: Membrane; Single-pass type III membrane protein

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	3
cytosol	2
extracellular	1
nucleus	1
peroxisome	1

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Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	--	--
GO:0016021	integral component of membrane	IEA	--

Find genes that share ontologies with SEMA5B About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for SEMA5B About

See pathways by source

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SuperPath

Contained pathways About

Axon guidance

Axon guidance

Find genes that share SuperPaths with SEMA5B About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 Reactome Pathway for SEMA5B

O-glycosylation of TSR domain-containing proteins

1 Kegg Pathway (Kegg details for SEMA5B):

Axon guidance

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for SEMA5B
Interactions:

Search GeneGlobe Interaction Network for SEMA5B

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

Selected Interacting proteins for SEMA5B (Q9P283^{2, 3} ENSP00000350215⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMN1	Q16637²^,³	MINT-8271498 I2D: score=2
SMN2	Q16637²^,³	MINT-8271498 I2D: score=2
ANXA7	P20073²^,³	MINT-8248702 I2D: score=2
C11orf58	O00193²^,³	MINT-8249876 I2D: score=2
FAM118B	Q9BPY3²^,³	MINT-8255200 I2D: score=2

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Gene Ontology (GO): 3 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007275	multicellular organismal development	--	--
GO:0007399	nervous system development	IEA	--
GO:0030154	cell differentiation	IEA	--

Find genes that share ontologies with SEMA5B About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for SEMA5B (SEM5B)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SEMA5B gene (5 alternative transcripts):

NM_018987.1 NM_001031702.3 NM_001256346.1 NM_001256347.1 NM_001256348.1

Unigene Cluster for SEMA5B:

Sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B

Hs.210870 [show with all ESTs]

Unigene Representative Sequence: NM_001256346

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000451541(uc003efy.1) ENST00000357599(uc003efz.1 uc011bju.1 uc010hro.1 uc010hrp.1)

ENST00000475244(uc003ega.1) ENST00000393583(uc003egb.1) ENST00000465147

ENST00000421053 ENST00000477001 ENST00000449546 ENST00000451055 ENST00000195173

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		hsa-miR-3194-5p hsa-miR-631 hsa-miR-15a hsa-miR-29a hsa-miR-29c hsa-miR-486-3p hsa-miR-3661 hsa-miR-424

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Additional mRNA sequence:

AB040878.1 AK001234.1 AK091481.1 AK291407.1 AK294528.1 AK295619.1 AK309834.1 AK309848.1

BC002776.2 BC077726.1 NR_046079.1

6 DOTS entries:

DT.75100789 DT.101980637 DT.92016969 DT.92422031 DT.92422033 DT.100662283

Selected AceView cDNA sequences (see all 53):

AK091481 AI479935 CR593104 AA862794 BC002776 BE301167 BM721339 BQ882487

BF436238 AI371424 BG325965 CB045671 BM701601 BF345903 AA045047 BF527649

BF529151 AU124266 BX419230 AA026150 AK001234 BQ012509 BG419769 AW149370

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for SEMA5B (see all 9) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14a	·	14b	^	15	^	16a	·	16b	^	17	^	18	^	19	^
SP1:			-		-		-		-		-		-																								-
SP2:									-		-		-																								-
SP3:													-																								-
SP4:									-		-		-		-						-		-
SP5:											-		-

ExUns:	20	^	21	^	22	^	23	^	24	^	25a	·	25b	^	26a	·	26b	·	26c	^	27a	·	27b
SP1:															-
SP2:													-		-
SP3:													-		-
SP4:
SP5:

ECgene alternative splicing isoforms for SEMA5B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SEMA5B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GGACCAAGGC

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SEMA5B expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 4) fully expand


Brain (Nervous System) fully expand to see all 5 entries
Mature Endothelial Cells Blood Brain Barrier
Cerebral Cortex

Testis (Reproductive System)
Leydig Cells Testis Interstitium

Endothelium (Cardiovascular System)
Mature Endothelial Cells Blood Brain Barrier

Eye (Sensory Organs)
Retina

SEMA5B Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

SEMA5B Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.210870

Custom PCR Arrays for SEMA5B

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for SEMA5B gene from Selected species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sema5b^{1 , 5}	sema domain, seven thrombospondin repeats (type 1 and more^{1, 5}	89.08(n)¹ 93.6(a)¹		16 (25.37 cM)⁵ 20357¹ NM_013661.2¹ NP_038689.2¹ 35541145⁵
chicken (Gallus gallus)	Aves	SEMA5B¹	sema domain, seven thrombospondin repeats (type 1 and more	71.99(n) 78.52(a)		424248 XM_422096.3 XP_422096.2
lizard (Anolis carolinensis)	Reptilia	SEMA5B⁶	sema domain, seven thrombospondin repeats (type 1 ...	78(a)	1 ↔ 1	1(83129175-83269448)
African clawed frog (Xenopus laevis)	Amphibia	MGC68835²	hypothetical protein MGC68835	78.35(n)		BC059288.1
zebrafish (Danio rerio)	Actinopterygii	sema5ba¹	sema domain, seven thrombospondin repeats (type 1 and more	67.4(n) 69.18(a)		556471 XM_679287.3 XP_684379.3
fruit fly (Drosophila melanogaster)	Insecta	Sema-1a³ Sema-5c¹	axon guidance³ Semaphorin-5c¹	40(a) (best of 5)³ 51.04(n)¹ 42.73(a)¹		37066¹ NM_137449.2¹ NP_611293.3¹

ENSEMBL Gene Tree for SEMA5B (if available)
TreeFam Gene Tree for SEMA5B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for SEMA5B gene

SEMA6D² SEMA6B² SEMA6C² SEMA5A² SEMA6A² SEMA7A²

11 SIMAP similar genes for SEMA5B using alignment to 7 protein entries: SEM5B_HUMAN (see all proteins):

SEMA5A SEMA6C SEMA3A SEMA4A SEMA3C SEMA4B

SEMA6D SEMA6B SEMA3F SEMA4D SEMA4C

Find genes that share paralogs with SEMA5B About GenesLikeMe

2 Pseudogenes.org Pseudogenes for SEMA5B
PGOHUM00000258303 PGOHUM00000258307

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_037196⁴		A breast cancer sample⁴	--	see VAR_037196	2	G S	mis⁴		0	--	--	--	--
VAR_037198⁴		A breast cancer sample⁴	--	see VAR_037198	2	I M	mis⁴		0	--	--	--	--
rs192429313^1,2		--	122627704(+)	`CATCAA/GCACTC`	5	--	ds500¹		0	--	--	--	--
rs113836293^1,2	C,F	--	122627877(+)	`ACACTG/CTATGT`	5	--	ds500¹		2		NA	122
rs183380318^1,2		--	122627904(+)	`AATGGA/TAAGAT`	5	--	ds500¹		0	--	--	--	--
rs140405867^1,2		--	122627929(+)	`ATAAGG/TCTACT`	5	--	ds500¹		0	--	--	--	--
rs144406374^1,2		--	122627950(+)	`CCCCCA/GCCTTG`	5	--	ds500¹		0	--	--	--	--
rs147834558^1,2	C	--	122627976(+)	`CCCTGA/GTGCAT`	5	--	ds500¹		0	--	--	--	--
rs187842485^1,2		--	122628051(+)	`TGGATA/GTCATC`	5	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs80353916^1,2	C,F	--	122628071(+)	`TAATGC/TCACAG`	5	--	ut3¹ nc-transcript-variant		2		NA EA	240

HapMap Linkage Disequilibrium report for SEMA5B (122628041 - 122747452 bp)

Structural Variations
Database of Genomic Variants (DGV) 7 variations for SEMA5B: About this table

Variant ID	Type	Subtype	PubMed ID
esv2678374	CNV	Deletion	23128226
esv998863	CNV	Insertion	20482838
nsv460836	CNV	Loss	19166990
nsv517695	CNV	Loss	19592680
nsv460835	CNV	Gain	19166990
nsv829706	CNV	Gain	17160897
nsv877393	CNV	Gain	21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 609298 OMIM disorders: --

Find genes that share disorders with SEMA5B About GenesLikeMe

Genetic Association Database (GAD): SEMA5B
Human Genome Epidemiology (HuGE) Navigator: SEMA5B (4 documents)

Export disorders for SEMA5B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SEMA5B gene, integrated from 10 sources (see all 20):
(articles sorted by number of sources associating them with SEMA5B)

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Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. (PubMed id 21642993)^{1, 4} Wu C....Lin D. (Nat. Genet. 2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (Genome Res. 2003)
Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)^{1, 2} Nagase T.... Ohara O. (DNA Res. 2000)
A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis. (PubMed id 8817451)^{1, 3} Adams R.H....PA1schel A.W. (Mech. Dev. 1996)
Semaphorin 5B mediates synapse elimination in hippocampal neurons. (PubMed id 19463192)^{1, 9} O'Connor T.P....Bamji S.X. (Neural Dev 2009)
A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (Sci Signal 2011)
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (Am. J. Hum. Genet. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 54437	HGNC: 10737	AceView: SEMA5B	Ensembl:ENSG00000082684	euGenes: HUgn54437
ECgene: SEMA5B	Kegg: 54437	H-InvDB: SEMA5B

(According to HUGE)
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HUGE: KIAA1445

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SEMA5B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SEMA5B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SEMA5B gene:
Search GeneIP for patents involving SEMA5B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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