Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SEMA5B Gene

protein-coding GIFtS: 55
GCID: GC03M122628

Sema Domain, Seven Thrombospondin Repeats (Type 1 And Type...

(Previous symbol: SEMAG)

8 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Sema Domain, Seven Thrombospondin Repeats (Type 1 And Type 1-Like), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 5B¹ ²
SEMAG¹ ² ³
SemG²
semaphorin-5B²
KIAA1445³

External Ids:	HGNC: 10737¹	Entrez Gene: 54437²	Ensembl: ENSG00000082684⁷	OMIM: 609298⁵	UniProtKB: Q9P283³

Export aliases for SEMA5B gene to outside databases

Previous GC identifers: GC03M119346 GC03M122576 GC03M123909 GC03M123948 GC03M124110 GC03M120001

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEMA5B Gene:

This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the

nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which

semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The

protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants

encoding different isoforms have been found for this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for SEMA5B Gene:

SEMA5B (sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B) is a protein-coding gene. Diseases associated with SEMA5B include clear cell renal cell carcinoma, and cerebral palsy. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA6D.

UniProtKB/Swiss-Prot: SEM5B_HUMAN, Q9P283

Function: May act as positive axonal guidance cues (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.2 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SEMA5B gene promoter:
NRSF form 1 Pax-2 Pax-2a NRSF form 2 POU2F1 POU2F1a Chx10 Ik-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SEMA5B promoter sequence

Search SABiosciences Chromatin IP Primers for SEMA5B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA5B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.1 Ensembl cytogenetic band: 3q21.1 HGNC cytogenetic band: 3q21.1

SEMA5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA5B gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M122628: view genomic region (about GC identifiers)

Start:	122,628,041 bp from pter	End:	122,747,452 bp from pter
Size:	119,412 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SEM5B_HUMAN, Q9P283 (See protein sequence)

Recommended Name: Semaphorin-5B

Size: 1151 amino acids; 125913 Da

Subcellular location: Membrane; Single-pass type III membrane protein

Caution: It is uncertain whether Met-1 or Met-59 is the initiator

Sequence caution: Sequence=BAA91570.1; Type=Erroneous initiation; Sequence=BAA95969.1; Type=Erroneous initiation;

Secondary accessions: A8K5U2 B7Z393 F8W9U8 Q6DD89 Q6UY12 Q9NW17

Alternative splicing: 4 isoforms: Q9P283-1 Q9P283-2 Q9P283-3 Q9P283-4 (No experimental confirmation available. Ref.3 (BAH12129) sequence is in conflict in position: 14:R->K)

Explore the universe of human proteins at neXtProt for SEMA5B: NX_Q9P283

Explore proteomics data for SEMA5B at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9P283

SEMA5B Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (4 alternative transcripts):

NP_001026872.2 NP_001243275.1 NP_001243276.1 NP_001243277.1

ENSEMBL proteins:

ENSP00000400828 ENSP00000350215 ENSP00000417570 ENSP00000377208 ENSP00000401056

ENSP00000401038 ENSP00000389588 ENSP00000195173

Human Recombinant Protein Products for SEMA5B:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for SEMA5B (Semaphorin 5B)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for SEMA5B OriGene Custom MassSpec OriGene Custom Protein Services for SEMA5B
	GenScript Custom Purified and Recombinant Proteins Services for SEMA5B
	Novus Biologicals SEMA5B Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for SEMA5B

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	IEA	--

SEMA5B for ontologies About GeneDecksing

SEMA5B Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for SEMA5B
	GenScript Custom Superior Antibodies Services for SEMA5B
	Novus Biologicals SEMA5B Antibody
	Abcam antibodies for SEMA5B
	Cloud-Clone Corp. Antibodies for SEMA5B
	Search ThermoFisher Antibodies for SEMA5B
	Search LSBio for Antibodies for SEMA5B

Assay Products for SEMA5B:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for SEMA5B
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SEMA5B
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for SEMA5B Cloud-Clone Corp. CLIAs for SEMA5B

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

SEMA: Semaphorins

5/7 InterPro protein domains (see all 7):

IPR000884 Thrombospondin_1_rpt

IPR003659 Plexin-like

IPR002165 Plexin_repeat

IPR016201 Plexin-like_fold

IPR027231 Semaphorin

Graphical View of Domain Structure for InterPro Entry Q9P283

ProtoNet protein and cluster: Q9P283

1 Blocks protein domain: IPB000884 Thrombospondin

UniProtKB/Swiss-Prot: SEM5B_HUMAN, Q9P283

Similarity: Belongs to the semaphorin family

Similarity: Contains 1 PSI domain

Similarity: Contains 1 Sema domain

Similarity: Contains 5 TSP type-1 domains

SEMA5B for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SEM5B_HUMAN, Q9P283

Function: May act as positive axonal guidance cues (By similarity)

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0005515	protein binding	--	--

SEMA5B for ontologies About GeneDecksing

Phenotypes:
7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Sema5b):

behavior/neurological	hematopoietic system	homeostasis/metabolism	immune system	nervous system
no phenotypic analysis	vision/eye

SEMA5B for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Sema5b^tm1.2Alk for SEMA5B

inGenious Targeting Laboratory - Custom generated mouse model solutions for SEMA5B

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SEMA5B

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEMA5B

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEMA5B

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA5B
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA5B (see all 22):
		hsa-miR-3194-5p hsa-miR-631 hsa-miR-15a hsa-miR-29a hsa-miR-29c hsa-miR-486-3p hsa-miR-3661 hsa-miR-424

		SwitchGear 3'UTR luciferase reporter plasmid: SEMA5B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for SEMA5B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA5B

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SEMA5B
			Sirion Biotech Customized adenovirus for overexpression of SEMA5B

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for SEMA5B (see all 7) OriGene ORF clones in mouse, rat for SEMA5B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SEMA5B (NM_001031702)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA5B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA5B
		Sirion Biotech Customized lentivirus for stable overexpression of SEMA5B Customized lentivirus expression plasmids for stable overexpression of SEMA5B

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SEMA5B
		Search LifeMap BioReagents cell lines for SEMA5B

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA5B

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for SEMA5B About

See pathways by source

SuperPath

Contained pathways About

Axon guidance

Axon guidance

Pathways by source See SuperPaths
Show all pathways

1 Kegg Pathway (Kegg details for SEMA5B):

Axon guidance

SEMA5B for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SEMA5B

5/9 Interacting proteins for SEMA5B (Q9P283^{2, 3}) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMN1	Q16637²^,³	MINT-8271498 I2D: score=2
SMN2	Q16637²^,³	MINT-8271498 I2D: score=2
ANXA7	P20073²^,³	MINT-8248702 I2D: score=2
C11orf58	O00193²^,³	MINT-8249876 I2D: score=2
FAM118B	Q9BPY3²^,³	MINT-8255200 I2D: score=2

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007275	multicellular organismal development	--	--
GO:0007399	nervous system development	IEA	--
GO:0030154	cell differentiation	IEA	--

SEMA5B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SEMA5B (SEM5B)

Search CenterWatch for drugs/clinical trials and news about SEMA5B / SEM5B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SEMA5B gene (5 alternative transcripts):

NM_018987.1 NM_001031702.3 NM_001256346.1 NM_001256347.1 NM_001256348.1

Unigene Cluster for SEMA5B:

Sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B

Hs.210870 [show with all ESTs]

Unigene Representative Sequence: NM_001256346

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000451541(uc003efy.1) ENST00000357599(uc003efz.1 uc011bju.1 uc010hro.1 uc010hrp.1)

ENST00000475244(uc003ega.1) ENST00000393583(uc003egb.1) ENST00000465147

ENST00000421053 ENST00000477001 ENST00000449546 ENST00000451055 ENST00000195173

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA5B
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA5B (see all 22):
		hsa-miR-3194-5p hsa-miR-631 hsa-miR-15a hsa-miR-29a hsa-miR-29c hsa-miR-486-3p hsa-miR-3661 hsa-miR-424

		SwitchGear 3'UTR luciferase reporter plasmid: SEMA5B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for SEMA5B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA5B

Clone Products:		OriGene clones in human, mouse for SEMA5B (see all 7) OriGene ORF clones in mouse, rat for SEMA5B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SEMA5B (NM_001031702)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA5B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA5B
		Sirion Biotech Customized lentivirus for stable overexpression of SEMA5B Customized lentivirus expression plasmids for stable overexpression of SEMA5B

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for SEMA5B
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SEMA5B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA5B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA5B

Additional mRNA sequence:

AB040878.1 AK001234.1 AK091481.1 AK291407.1 AK294528.1 AK295619.1 AK309834.1 AK309848.1

BC002776.2 BC077726.1 NR_046079.1

6 DOTS entries:

DT.75100789 DT.101980637 DT.92016969 DT.92422031 DT.92422033 DT.100662283

24/53 AceView cDNA sequences (see all 53):

AI479935 CR593104 AK091481 AA862794 BC002776 BE301167 AK001234 BM713996

CB045671 BG422528 AA045047 BM701601 BF527649 BF436238 AI371424 BM721339

BE044353 BF345903 BQ882487 BQ012509 AA026150 BF529151 AU124266 BF037176

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SEMA5B (see all 9) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14a	·	14b	^	15	^	16a	·	16b	^	17	^	18	^	19	^
SP1:			-		-		-		-		-		-																								-
SP2:									-		-		-																								-
SP3:													-																								-
SP4:									-		-		-		-						-		-
SP5:											-		-

ExUns:	20	^	21	^	22	^	23	^	24	^	25a	·	25b	^	26a	·	26b	·	26c	^	27a	·	27b
SP1:															-
SP2:													-		-
SP3:													-		-
SP4:
SP5:

ECgene alternative splicing isoforms for SEMA5B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SEMA5B expression in normal human tissues (normalized intensities) SEMA5B embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GGACCAAGGC

About this image

SEMA5B expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/15 selected tissues (see all 15) fully expand


Brain (Nervous System) fully expand to see all 5 entries
Postnatal Endothelial Cells Blood Brain Barrier
Cerebral Cortex

Lung (Respiratory System) fully expand to see all 2 entries
bronchus ; respiratory epithelial cells

Epithelium (Uncategorized) fully expand to see all 2 entries
vagina ; squamous epithelial cells

Testis (Reproductive System)
Leydig Cells Testis Interstitium

Blood Brain Barrier (Nervous System)
Postnatal Endothelial Cells Blood Brain Barrier

See SEMA5B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEMA5B

SOURCE GeneReport for Unigene cluster: Hs.210870

SABiosciences Custom PCR Arrays for SEMA5B

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for SEMA5B
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SEMA5B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA5B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA5B

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA5B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SEMA5B gene from 6/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sema5b^{1 , 5}	sema domain, seven thrombospondin repeats (type 1 and more^{1, 5}	89.08(n)¹ 93.6(a)¹		16 (25.37 cM)⁵ 20357¹ NM_013661.2¹ NP_038689.2¹ 35541145⁵
chicken (Gallus gallus)	Aves	SEMA5B¹	sema domain, seven thrombospondin repeats (type 1 and more	71.67(n) 78.02(a)		424248 XM_422096.2 XP_422096.2
lizard (Anolis carolinensis)	Reptilia	SEMA5B⁶	Uncharacterized protein	78(a)	1 ↔ 1	1(83129175-83269448)
African clawed frog (Xenopus laevis)	Amphibia	MGC68835²	hypothetical protein MGC68835	78.35(n)		BC059288.1
zebrafish (Danio rerio)	Actinopterygii	sema5b¹	sema domain, seven thrombospondin repeats (type 1 and more	66.42(n) 67.78(a)		556471 XM_679287.2 XP_684379.2
fruit fly (Drosophila melanogaster)	Insecta	Sema-1a³ Sema-5c¹	axon guidance³ Semaphorin-5c¹	40(a) (best of 5)³ 50.96(n)¹ 42.73(a)¹		37066¹ NM_137449.2¹ NP_611293.3¹

ENSEMBL Gene Tree for SEMA5B (if available)
TreeFam Gene Tree for SEMA5B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SEMA5B gene

SEMA6D² SEMA6B² SEMA6C² SEMA5A² SEMA6A² SEMA7A²

11 SIMAP similar genes for SEMA5B using alignment to 7 protein entries: SEM5B_HUMAN (see all proteins):

SEMA5A SEMA6C SEMA3A SEMA4A SEMA3C SEMA4B

SEMA6D SEMA6B SEMA3F SEMA4D SEMA4C

SEMA5B for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for SEMA5B
PGOHUM00000258303 PGOHUM00000258307

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_037196⁴		A breast cancer sample⁴	--	see VAR_037196	2	G S	mis⁴		0	--	--	--	--
VAR_037198⁴		A breast cancer sample⁴	--	see VAR_037198	2	I M	mis⁴		0	--	--	--	--
rs192429313^1,2		--	122627704(+)	`CATCAA/GCACTC`	5	--	ds500¹		0	--	--	--	--
rs113836293^1,2	C,F	--	122627877(+)	`ACACTG/CTATGT`	5	--	ds500¹		2		NA	122
rs183380318^1,2		--	122627904(+)	`AATGGA/TAAGAT`	5	--	ds500¹		0	--	--	--	--
rs140405867^1,2		--	122627929(+)	`ATAAGG/TCTACT`	5	--	ds500¹		0	--	--	--	--
rs144406374^1,2		--	122627950(+)	`CCCCCA/GCCTTG`	5	--	ds500¹		0	--	--	--	--
rs147834558^1,2	C	--	122627976(+)	`CCCTGA/GTGCAT`	5	--	ds500¹		0	--	--	--	--
rs187842485^1,2		--	122628051(+)	`TGGATA/GTCATC`	5	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs80353916^1,2	C,F	--	122628071(+)	`TAATGC/TCACAG`	5	--	ut3¹ nc-transcript-variant		2		NA EA	240

HapMap Linkage Disequilibrium report for SEMA5B (122628041 - 122747452 bp)

Structural Variations
Database of Genomic Variants (DGV) 7 variations for SEMA5B: About this table

Variant ID	Type	Subtype	PubMed ID
esv2678374	CNV	Deletion	23128226
esv998863	CNV	Insertion	20482838
nsv460836	CNV	Loss	19166990
nsv517695	CNV	Loss	19592680
nsv460835	CNV	Gain	19166990
nsv829706	CNV	Gain	17160897
nsv877393	CNV	Gain	21882294

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEMA5B

DNA2.0 Custom Variant and Variant Library Synthesis for SEMA5B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 609298 OMIM disorders: --

8 diseases for SEMA5B: About MalaCards

clear cell renal cell carcinoma cerebral palsy renal cell carcinoma esophageal squamous cell carcinoma

cerebritis esophagitis squamous cell carcinoma neuronitis

SEMA5B for disorders About GeneDecksing

Genetic Association Database (GAD): SEMA5B
Human Genome Epidemiology (HuGE) Navigator: SEMA5B (4 documents)

Export disorders for SEMA5B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SEMA5B gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with SEMA5B)

Utopia: connect your pdf to the dynamic
world of online information

Genome-wide association study identifies three new su sceptibility loci for esophageal squamous-cell carcinoma in Chinese populations . (PubMed id 21642993)^{1, 4} Wu C....Lin D. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)^{1, 2} Nagase T.... Ohara O. (2000)
A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis. (PubMed id 8817451)^{1, 3} Adams R.H....Puschel A.W. (1996)
Semaphorin 5B mediates synapse elimination in hippoca mpal neurons. (PubMed id 19463192)^{1, 9} O'Connor T.P....Bamji S.X. (2009)
A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 54437	HGNC: 10737	AceView: SEMA5B	Ensembl:ENSG00000082684	euGenes: HUgn54437
ECgene: SEMA5B	Kegg: 54437	H-InvDB: SEMA5B

(According to HUGE)
About This Section

HUGE: KIAA1445

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SEMA5B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SEMA5B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SEMA5B gene:
Search GeneIP for patents involving SEMA5B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Recombinant/Natural Proteins for SEMA5B (Semaphorin 5B)
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for SEMA5B
	Browse OriGene qPCR primer pairs and template standards		OriGene Protein Over-expression Lysate for SEMA5B
	OriGene Custom Mass Spec		OriGene clones in human, mouse for SEMA5B
	OriGene qSTAR qPCR primer pairs in human, mouse for SEMA5B		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for SEMA5B		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SEMA5B		OriGene Custom Protein Services for SEMA5B

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SEMA5B
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEMA5B
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA5B
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA5B
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA5B
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA5B

	GenScript Custom Purified and Recombinant Proteins Services for SEMA5B		GenScript cDNA clones with any tag delivered in your preferred vector for SEMA5B
	GenScript Custom Assay Services for SEMA5B		GenScript Custom Superior Antibodies Services for SEMA5B
	GenScript Custom overexpressing Cell Line Services for SEMA5B		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in SEMA5B promoter
	Search Chromatin IP Primers for SEMA5B
	RT² qPCR Primer Assay in human, mouse, rat SEMA5B
	Search GNC Networks for SEMA5B
	SABiosciences Custom PCR Arrays for SEMA5B

Search Tocris compounds for SEMA5B (SEM5B)

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SEMA5B antibodies
	SEMA5B lysates

	Antibodies for SEMA5B
	See all of Abcam's Antibodies, Kits and Proteins for SEMA5B
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for SEMA5B
	Antibodies for SEMA5B
	ELISAs for SEMA5B
	CLIAs for SEMA5B

Search LifeMap BioReagents cell lines for SEMA5B

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA5B

	SwitchGear 3'UTR luciferase reporter plasmids for SEMA5B
	SwitchGear Promoter luciferase reporter plasmids for SEMA5B

Search ThermoFisher Antibodies for SEMA5B

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA5B

	inGenious Targeting Laboratory - Custom generated mouse model solutions for SEMA5B
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SEMA5B

Customized:

	lentivirus for stable overexpression of SEMA5B
	lentivirus expression plasmids for stable overexpression of SEMA5B
	adenovirus for overexpression of SEMA5B

Search LSBio for Antibodies for SEMA5B

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SEMA5B gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

SEMA5B Gene

Sema Domain, Seven Thrombospondin Repeats (Type 1 And Type...

Aliases
for SEMA5B gene

Summaries
for SEMA5B gene

Genomic Views
for SEMA5B gene

Proteins
for SEMA5B gene

Protein Domains /
Families
for SEMA5B gene

Function
for SEMA5B gene

Pathways & Interactions
for SEMA5B gene

Drugs & Compounds
for SEMA5B gene

Transcripts
for SEMA5B gene

Expression
for SEMA5B gene

Orthologs
for SEMA5B gene

Paralogs
for SEMA5B gene

Genomic Variants
for SEMA5B gene

Disorders / Diseases
for SEMA5B gene

Publications
for SEMA5B gene

External Searches for SEMA5B gene

Genome Databases showing SEMA5B gene

Other Databases showing SEMA5B gene

Specialized Databases showing SEMA5B gene

Intellectual Property
for SEMA5B gene

Products
for SEMA5B gene

View Random Gene

Advanced Search

Export list of displayed genes

SEMA5B Gene

Sema Domain, Seven Thrombospondin Repeats (Type 1 And Type...

Aliasesfor SEMA5B gene

Summariesfor SEMA5B gene

Genomic Viewsfor SEMA5B gene

Proteinsfor SEMA5B gene

Protein Domains /Familiesfor SEMA5B gene

Functionfor SEMA5B gene

Pathways & Interactionsfor SEMA5B gene

Drugs & Compoundsfor SEMA5B gene

Transcriptsfor SEMA5B gene

Expression for SEMA5B gene

Orthologsfor SEMA5B gene

Paralogsfor SEMA5B gene

Genomic Variantsfor SEMA5B gene

Disorders / Diseasesfor SEMA5B gene

Publicationsfor SEMA5B gene

External Searches for SEMA5B gene

Genome Databases showing SEMA5B gene

Other Databases showing SEMA5B gene

Specialized Databases showing SEMA5B gene

Intellectual Propertyfor SEMA5B gene

Productsfor SEMA5B gene

View Random Gene

Aliases
for SEMA5B gene

Summaries
for SEMA5B gene

Genomic Views
for SEMA5B gene

Proteins
for SEMA5B gene

Protein Domains /
Families
for SEMA5B gene

Function
for SEMA5B gene

Pathways & Interactions
for SEMA5B gene

Drugs & Compounds
for SEMA5B gene

Transcripts
for SEMA5B gene

Expression
for SEMA5B gene

Orthologs
for SEMA5B gene

Paralogs
for SEMA5B gene

Genomic Variants
for SEMA5B gene

Disorders / Diseases
for SEMA5B gene

Publications
for SEMA5B gene

Intellectual Property
for SEMA5B gene

Products
for SEMA5B gene