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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SEMA5B Gene

protein-coding GIFtS: 55
GCID: GC03M122628

sema domain, seven thrombospondin repeats (type 1 and type...

(Previous symbol: SEMAG)

Explore 9 diseases affiliated with
SEMA5B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sema Domain, Seven Thrombospondin Repeats (Type 1 And Type 1-Like), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 5B¹ ²
SEMAG¹ ² ³
SemG¹ ²
KIAA1445¹ ³
FLJ10372¹
Semaphorin-5B¹

External Ids:	HGNC: 10737¹	Entrez Gene: 54437²	Ensembl: ENSG00000082684⁷	OMIM: 609298⁵	UniProtKB: Q9P283³

Export aliases for SEMA5B gene to outside databases

Previous GC identifers: GC03M119346 GC03M122576 GC03M123909 GC03M123948 GC03M124110 GC03M120001

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEMA5B:

This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the

nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins

bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product

may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different

isoforms have been found for this gene. (provided by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: SEM5B_HUMAN, Q9P283

Function: May act as positive axonal guidance cues (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SEMA5B gene promoter:
NRSF form 1 Pax-2 Pax-2a NRSF form 2 POU2F1 POU2F1a Chx10 Ik-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SEMA5B promoter sequence

Search SABiosciences Chromatin IP Primers for SEMA5B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA5B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.1 Ensembl cytogenetic band: 3q21.1 HGNC cytogenetic band: 3q21.1

SEMA5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA5B gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M122628: view genomic region (about GC identifiers)

Start:	122,628,041 bp from pter	End:	122,747,452 bp from pter
Size:	119,412 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SEM5B_HUMAN, Q9P283 (See protein sequence)

Recommended Name: Semaphorin-5B

Size: 1151 amino acids; 125913 Da

Subcellular location: Membrane; Single-pass type III membrane protein

Caution: It is uncertain whether Met-1 or Met-59 is the initiator

Sequence caution: Sequence=BAA91570.1; Type=Erroneous initiation; Sequence=BAA95969.1; Type=Erroneous initiation;

Secondary accessions: A8K5U2 B7Z393 F8W9U8 Q6DD89 Q6UY12 Q9NW17

Alternative splicing: 4 isoforms: Q9P283-1 Q9P283-2 Q9P283-3 Q9P283-4 (No experimental confirmation available. Ref.3 (BAH12129) sequence is in conflict in position: 14:R->K)

Explore the universe of human proteins at neXtProt for SEMA5B: NX_Q9P283

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9P283

SEMA5B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001026872.2 NP_001243275.1 NP_001243276.1 NP_001243277.1

ENSEMBL proteins:

ENSP00000350215 ENSP00000417570 ENSP00000400828 ENSP00000377208 ENSP00000401056

ENSP00000401038 ENSP00000389588 ENSP00000195173

Human Recombinant Protein Products:

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	Novus Biologicals SEMA5B Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SEMA5B

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

SEMA5B for ontologies About GeneDecksing

SEMA5B Antibody Products:

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	Uscn ELISAs and CLIAs for SEMA5B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SEMA5B for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR000884 Thrombospondin_1_rpt

IPR003659 Plexin-like

IPR002165 Plexin_repeat

IPR016201 Plexin-like_fold

IPR027231 Semaphorin

Graphical View of Domain Structure for InterPro Entry Q9P283

ProtoNet protein and cluster: Q9P283

1 Blocks protein family: IPB000884 Thrombospondin

UniProtKB/Swiss-Prot: SEM5B_HUMAN, Q9P283

Similarity: Belongs to the semaphorin family

Similarity: Contains 1 PSI domain

Similarity: Contains 1 Sema domain

Similarity: Contains 5 TSP type-1 domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SEM5B_HUMAN, Q9P283

Function: May act as positive axonal guidance cues (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: SEMA5B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA5B
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA5B (see all 22):
		hsa-miR-3194-5p hsa-miR-631 hsa-miR-15a hsa-miR-29a hsa-miR-29c hsa-miR-486-3p hsa-miR-3661 hsa-miR-424

		SwitchGear 3'UTR luciferase reporter plasmid: SEMA5B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA5B (see all 7) OriGene shRNA RFP: SEMA5B OriGene siRNA: SEMA5B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA5B

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SEMA5B

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA5B (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA5B OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SEMA5B (NM_001031702)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA5B
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SEMA5B
		Search LifeMap BioReagents cell lines for SEMA5B

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA5B

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--

SEMA5B for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Sema5b^tm1.2Alk for SEMA5B
     7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Sema5b):

behavior/neurological	hematopoietic system	homeostasis/metabolism	immune system	nervous system
no phenotypic analysis	vision/eye

SEMA5B for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Axon guidance

Axon guidance

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Kegg Pathway (Kegg details for SEMA5B):

Axon guidance

SEMA5B for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SEMA5B

5/9 Interacting proteins for SEMA5B (Q9P283^{2, 3}) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMN1	Q16637²^,³	MINT-8271498 I2D: score=2
SMN2	Q16637²^,³	MINT-8271498 I2D: score=2
ANXA7	P20073²^,³	MINT-8248702 I2D: score=2
C11orf58	O00193²^,³	MINT-8249876 I2D: score=2
FAM118B	Q9BPY3²^,³	MINT-8255200 I2D: score=2

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007275	multicellular organismal development	--	--
GO:0007399	nervous system development	IEA	--
GO:0030154	cell differentiation	IEA	--

SEMA5B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SEMA5B
Search CenterWatch for drugs/clinical trials and news about SEMA5B / SEM5B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SEMA5B gene (5 alternative transcripts):

NM_018987.1 NM_001031702.3 NM_001256346.1 NM_001256347.1 NM_001256348.1

Unigene Cluster for SEMA5B:

Sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B

Hs.210870 [show with all ESTs]

Unigene Representative Sequence: NM_001256346

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000357599(uc003efz.1 uc011bju.1 uc010hro.1 uc010hrp.1)

ENST00000475244(uc003ega.1) ENST00000451541(uc003efy.1) ENST00000393583(uc003egb.1)

ENST00000465147 ENST00000421053 ENST00000477001 ENST00000449546 ENST00000451055

ENST00000195173

miRNA Products:		OriGene 3'-UTR Clone: SEMA5B Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA5B
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA5B (see all 22):
		hsa-miR-3194-5p hsa-miR-631 hsa-miR-15a hsa-miR-29a hsa-miR-29c hsa-miR-486-3p hsa-miR-3661 hsa-miR-424

		SwitchGear 3'UTR luciferase reporter plasmid: SEMA5B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA5B (see all 7) OriGene shRNA RFP: SEMA5B OriGene siRNA: SEMA5B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA5B

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA5B (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA5B OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SEMA5B (NM_001031702)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA5B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA5B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEMA5B Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA5B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA5B

Additional cDNA sequence:

AB040878.1 AK001234.1 AK091481.1 AK291407.1 AK294528.1 AK295619.1 AK309834.1 AK309848.1

BC002776.2 BC077726.1 NR_046079.1

6 DOTS entries:

DT.75100789 DT.101980637 DT.92016969 DT.92422031 DT.92422033 DT.100662283

24/53 AceView cDNA sequences (see all 53):

AI479935 CR593104 BE301167 BC002776 AK091481 AA862794 AI371424 BF527649

BG325965 BQ882487 BF345903 AA045047 BM721339 BF436238 BM713996 AA026150

AA045048 BG913276 BX411341 BM677077 BX431010 BG913542 BX431009 AI500330

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SEMA5B (see all 9) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14a	·	14b	^	15	^	16a	·	16b	^	17	^	18	^	19	^
SP1:			-		-		-		-		-		-																								-
SP2:									-		-		-																								-
SP3:													-																								-
SP4:									-		-		-		-						-		-
SP5:											-		-

ExUns:	20	^	21	^	22	^	23	^	24	^	25a	·	25b	^	26a	·	26b	·	26c	^	27a	·	27b
SP1:															-
SP2:													-		-
SP3:													-		-
SP4:
SP5:

ECgene alternative splicing isoforms for SEMA5B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SEMA5B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGACCAAGGC

About this image

SEMA5B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SEMA5B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEMA5B

SOURCE GeneReport for Unigene cluster: Hs.210870

SABiosciences Custom PCR Arrays for SEMA5B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEMA5B Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA5B

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA5B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SEMA5B gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SEMA5B¹	sema domain, seven thrombospondin repeats (type 1 and more	71.67(n) 78.02(a)		424248 XM_422096.2 XP_422096.2
lizard (Anolis carolinensis)	Reptilia	SEMA5B⁶	--	78(a)	1 ↔ 1	1(83129175-83269448)
African clawed frog (Xenopus laevis)	Amphibia	MGC68835²	hypothetical protein MGC68835	78.35(n)		BC059288.1
zebrafish (Danio rerio)	Actinopterygii	sema5b¹	sema domain, seven thrombospondin repeats (type 1 and more	66.42(n) 67.78(a)		556471 XM_679287.2 XP_684379.2
fruit fly (Drosophila melanogaster)	Insecta	Sema-1a³ Sema-5c¹	axon guidance³ Semaphorin-5c¹	40(a) (best of 5)³ 50.96(n)¹ 42.73(a)¹		37066¹ NM_137449.2¹ NP_611293.3¹
worm (Caenorhabditis elegans)	Secernentea	C36B7.5a³	type-I thrombospondin TSR repeats	31(a) (best of 4)		X(7124484-7131593) --

ENSEMBL Gene Tree for SEMA5B (if available)
TreeFam Gene Tree for SEMA5B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SEMA5B gene

SEMA6D² SEMA6B² SEMA6C² SEMA6A² SEMA7A² SEMA5A²

11 SIMAP similar genes for SEMA5B using alignment to 7 protein entries: SEM5B_HUMAN (see all proteins):

SEMA5A SEMA6C SEMA3A SEMA4A SEMA3C SEMA4B

SEMA6D SEMA6B SEMA3F SEMA4D SEMA4C

SEMA5B for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for SEMA5B
PGOHUM00000258303 PGOHUM00000258307

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs192429313^1,2		--	122627704(+)	`CATCAA/GCACTC`	5	--	ds500¹		0	--	--	--	--
rs113836293^1,2	C,	--	122627877(+)	`ACACTG/CTATGT`	5	--	ds500¹		2		NA	122
rs183380318^1,2		--	122627904(+)	`AATGGA/TAAGAT`	5	--	ds500¹		0	--	--	--	--
rs140405867^1,2		--	122627929(+)	`ATAAGG/TCTACT`	5	--	ds500¹		0	--	--	--	--
rs144406374^1,2		--	122627950(+)	`CCCCCA/GCCTTG`	5	--	ds500¹		0	--	--	--	--
rs147834558^1,2		--	122627976(+)	`CCCTGA/GTGCAT`	5	--	ds500¹		0	--	--	--	--
rs187842485^1,2		--	122628051(+)	`TGGATA/GTCATC`	5	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs80353916^1,2	F,	--	122628071(+)	`TAATGC/TCACAG`	5	--	ut3¹ nc-transcript-variant		2		NA EA	240
rs10524993^1,2	C,	--	122628113(+)	`GTGAT-/TGTG TGTGCGTGTGT`	5	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs71845812^1,2	C,	--	122628130(+)	`GTGAG-/GTTGTGT`	5	--	ut3¹ nc-transcript-variant		0	--	--	--	--

HapMap Linkage Disequilibrium report for SEMA5B (122628041 - 122747452 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SEMA5B
1 CNV: 50918
1 Indel: 50919

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEMA5B

DNA2.0 Custom Variant and Variant Library Synthesis for SEMA5B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SEMA5B for disorders           About GeneDecksing

OMIM gene information: 609298    OMIM disorders: --

9 diseases for SEMA5B:    About MalaCards

clear cell renal cell carcinoma esophageal squamous cell carcinoma renal cell carcinoma squamous cell carcinoma

cerebral palsy cerebritis esophagitis carcinoma

neuronitis

Human Genome Epidemiology (HuGE) Navigator: SEMA5B (4 documents)

Export disorders for SEMA5B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SEMA5B gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with SEMA5B)

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Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)^{1, 2} Nagase T.... Ohara O. (2000)
A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis. (PubMed id 8817451)^{1, 3} Adams R.H....Puschel A.W. (1996)
Semaphorin 5B mediates synapse elimination in hippoca mpal neurons. (PubMed id 19463192)^{1, 9} O'Connor T.P....Bamji S.X. (2009)
A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
Genome-wide association study identifies three new su sceptibility loci for esophageal squamous-cell carcinoma in Chinese populations . (PubMed id 21642993)¹ Wu C....Lin D. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 54437	HGNC: 10737	AceView: SEMA5B	Ensembl:ENSG00000082684	euGenes: HUgn54437
ECgene: SEMA5B	Kegg: 54437	H-InvDB: SEMA5B

(According to HUGE)
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HUGE: KIAA1445

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SEMA5B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SEMA5B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SEMA5B gene:
Search GeneIP for patents involving SEMA5B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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sema domain, seven thrombospondin repeats (type 1 and type...

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