SEMA5A Gene

Aliases
for SEMA5A gene

Previous GC identifers: GC05M009206 GC05M009071 GC05M009091

Summaries
for SEMA5A gene

Genomic Views
for SEMA5A gene

RefSeq DNA sequence:

NC_000005.9  NC_018916.1  NT_006576.16  

SwitchGear Promoter luciferase reporter plasmid: SEMA5A promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA5A

SEMA5A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M009036:  view genomic region     (about GC identifiers)

Proteins
for SEMA5A gene

Explore the universe of human proteins at neXtProt for SEMA5A: NX_Q13591

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for SEMA5A (Semaphorin 5A)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: SEMA5A OriGene Protein Over-expression Lysate: SEMA5A OriGene Custom Protein Services for SEMA5A
	GenScript Custom Purified and Recombinant Proteins Services for SEMA5A
	Novus Biologicals SEMA5A Protein Novus Biologicals SEMA5A Lysate
	Sino Biological Recombinant Protein for SEMA5A
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SEMA5A

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for SEMA5A (Semaphorin 5A)
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	GenScript Custom Superior Antibodies Services for SEMA5A
	Novus Biologicals SEMA5A Antibodies
	Abcam antibodies for SEMA5A
	Uscn Antibodies for SEMA5A
	ThermoFisher Antibodies for SEMA5A

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SEMA5A
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SEMA5A

Protein Domains /
Families
for SEMA5A gene

ProtoNet protein and cluster: Q13591

Function
for SEMA5A gene

miRNA Products:		OriGene 3'-UTR Clone: SEMA5A Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA5A
		8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA5A (see all 78):
		hsa-miR-3938 hsa-miR-106a hsa-miR-374a hsa-miR-578 hsa-miR-3142 hsa-miR-298 hsa-miR-93 hsa-miR-4325
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA5A (see all 7) OriGene shRNA RFP: SEMA5A OriGene siRNA: SEMA5A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA5A

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SEMA5A

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA5A (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA5A OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SEMA5A (NM_003966)
		Sino Biological Human cDNA Clone for SEMA5A
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA5A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA5A

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SEMA5A
		Search LifeMap BioReagents cell lines for SEMA5A

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA5A

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

(inferred from 4 alleles) (MGI details for Sema5a)

Pathways & Interactions
for SEMA5A gene

	Super-pathway	contained gene-specific pathways
1	Apoptotic Pathways in Synovial Fibroblasts	8/14 pathways (see all 14) Apoptotic Pathways in Synovial Fibroblasts 1.00 ERK5 Signaling 0.61 p53 Mediated Apoptosis 0.84 eIF2 Pathway 0.60 Mitochondrial Apoptosis 0.73 Rac1 Pathway 0.58 Telomerase Components in Cell Signaling 0.72 Nuclear Receptor Activation by Vitamin-A 0.57
2	GPCR Pathway	GPCR Pathway 1.00 Estrogen Pathway 0.55 Ras Pathway 0.62 Pancreatic Adenocarcinoma 0.55 Breast Cancer Regulation by Stathmin1 0.58 Paxillin Interactions 0.53 NFAT in Immune Response 0.58
3	Rho Family GTPases	Rho Family GTPases 1.00 MAPK Signaling 0.51 ERK Signaling 0.61 ILK Signaling 0.45 Molecular Mechanisms of Cancer 0.51
4	TGF-Beta Pathway	TGF-Beta Pathway 1.00 JAK-STAT Pathway 0.57 MAPK Family Pathway 0.60 JNK Pathway 0.50
5	Nanog in Mammalian ESC Pluripotency	Nanog in Mammalian ESC Pluripotency 1.00 14-3-3 Induced Intracellular Signaling 0.59 GSK3 Signaling 0.61 eNOS Signaling 0.48

5/54 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SEMA5A

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

4        Reactome Pathways for SEMA5A

	Developmental Biology
	Semaphorin interactions
	Other semaphorin interactions
	Axon guidance

1         Kegg Pathway  (Kegg details for SEMA5A)

Axon guidance

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

Drugs & Compounds
for SEMA5A gene

Transcripts
for SEMA5A gene

Expression
for SEMA5A gene

SEMA5A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

10/13 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 13)
	Tissue Anatomical Compartment Cell			Category (developmental path)
	KidneyS-shaped BodyS-shaped Body Cells			Kidney
	Reproductive SystemMesonephrosMesonephric cells			Reproductive System
	BrainHypothalamus			Brain
	BrainThalamus			Brain
	KidneyEpithelial Tubule			Kidney
	KidneyGlomerulus			Kidney
	KidneyInterstitial Stroma			Kidney
	KidneyMetanephros			Kidney
	KidneyS-shaped Body			Kidney
	Lower Urinary TractUreter			Lower Urinary Tract
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 6 LifeMap Cells
	Name			Category
	PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)			Adipose, Bone, Cartilage
	PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
	PureStem™ progenitor U31 (Embryonic Progenitor Cell)
	Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)			Early Embryo, Inner Cell Mass
	Definitive endoderm-like cells (A scalable, suspensi...)
	Mature follicles (In-vitro growth and ...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEMA5A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEMA5A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA5A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA5A

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA5A

Orthologs
for SEMA5A gene

Paralogs
for SEMA5A gene

Paralogs for SEMA5A gene

SEMA6D²  SEMA6B²  SEMA6C²  SEMA6A²  SEMA7A²  SEMA5B²  

9 SIMAP similar genes for SEMA5A using alignment to 4 protein entries:     SEM5A_HUMAN (see all proteins):

SEMA5B    SEMA6D    SEMA4F    SEMA4A    SEMA3F    SEMA3C

SEMA4B    SEMA4C    SEMA4G

SEMA5A for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for SEMA5A
PGOHUM00000235118 PGOHUM00000235501

Genomic Variants
for SEMA5A gene

10/9985 NCBI SNPs in SEMA5A are shown (see all 9985)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs744935551,2		--	9020123(+)	GCATGT/CATATT	1	--	ds5001		1		WA	118
rs14577681,2	C,F,O,H,	--	9020154(-)	TTTCAA/CTGTTC	1	--	ds5001		11		NS EA NA WA	804
rs1150024811,2	C,F,	--	9020300(+)	GGTAAG/ATATAA	1	--	ds5001		1		WA	118
rs168818711,2	C,F,H,	--	9020476(+)	GAAGAT/CAAACA	1	--	ds5001		9		NA NS EA	738
rs730436241,2	C,	--	9021002(+)	GGTGTG/CAGTTG	1	--	ut31		2		WA	120
rs1997333961,2	C	--	9021551(+)	TTTCAA/CAAAAA	1	--	ut31		0	--	--	--	--
rs100460851,2	C,F,H,	--	9021644(+)	CATTTG/TATAAC	1	--	ut31 ese3		5		NS EA WA	538
rs784567831,2	F,	--	9022815(+)	CTGTAA/CAACAT	1	--	ut31		2		WA NA	238
rs775226961,2	C,F,	--	9023046(+)	TTCCTC/TATGCT	1	--	ut31		1		NA	120
rs168818751,2	C,F,H,	--	9023518(+)	TATGCG/ATTTCT	1	--	ut31 ese3		23		NA NS EA WA	2904

HapMap Linkage Disequilibrium report for SEMA5A (9035138 - 9285138 bp, first 250kb of SEMA5A)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 15 variations for SEMA5A
     1 CNV: 99056
     14 Indels: 62344 12651 46941 46943 28033 12652 41876 40731 62343 64114 99055 42365 28032 46942

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEMA5A

DNA2.0 Custom Variant and Variant Library Synthesis for SEMA5A

Disorders / Diseases
for SEMA5A gene

Publications
for SEMA5A gene

PubMed articles for SEMA5A gene, integrated from 9 sources (see all 41): (articles sorted by number of sources associating them with SEMA5A)

Utopia: connect your pdf to the dynamic world of online information

1. Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval. (PubMed id 9464278)^{1, 2, 3, 9} Simmons A.D....Lovett M. (1998)
2. Plexin-B3 is a functional receptor for semaphorin 5A. (PubMed id 15218527)^{1, 2, 9} Artigiani S.... Tamagnone L. (2004)
3. Semaphorin 5A and plexin-B3 regulate human glioma cell motility and morphology through Rac1 and the actin cytoskeleton. (PubMed id 21706053)^{1, 2} Li X....Lee A.Y. (2012)
4. Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase. (PubMed id 20696765)^{1, 2} Li X. and Lee A.Y. (2010)
5. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)^{1, 2} Schmutz J.... Rubin E.M. (2004)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
7. A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis. (PubMed id 8817451)^{1, 3} Adams R.H....Puschel A.W. (1996)
8. Semaphorin 5A promotes angiogenesis by increasing end othelial cell proliferation, migration, and decreasing apoptosis. (PubMed id 19850054)^{2, 9} Sadanandam A....Singh R.K. (2010)
9. [Correlation study of semaphorin 5a with risk of Park inson's disease in a Chinese Han population] (PubMed id 19957501)^{1, 9} Dong H.R....Ding X.S. (2009)
10. Association study of semaphorin 5A with risk of Parkinson's disease in a Chinese Han population. (PubMed id 18950607)^{1, 9} Ding H....Zhang Q. (2008)

External Searches for SEMA5A gene

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Products
for SEMA5A gene