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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEMA4G Gene

protein-coding   GIFtS: 57
GCID: GC10P102719

Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And
Short Cytoplasmic Domain, (Semaphorin) 4G1 2
semaphorin-4G2
KIAA16193

External Ids:    HGNC: 107351   Entrez Gene: 577152   Ensembl: ENSG000000955397   UniProtKB: Q9NTN93   

Export aliases for SEMA4G gene to outside databases

Previous GC identifers: GC10P101625 GC10P101966 GC10P102860 GC10P102396 GC10P096361


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEMA4G Gene:
Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin
(Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular
portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates
contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon
guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Feb 2011)

GeneCards Summary for SEMA4G Gene: 
SEMA4G (sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G) is a protein-coding gene. Diseases associated with SEMA4G include renal cell carcinoma, and alzheimer's disease, and among its related super-pathways are Rac1 Pathway and Ras Pathway. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA3C.

UniProtKB/Swiss-Prot: SEM4G_HUMAN, Q9NTN9
Function: Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity)

Gene Wiki entry for SEMA4G Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEMA4G gene promoter:
         RFX1   p53   FOXO3   Lmo2   FOXD3   CUTL1   E47   FOXO3b   HNF-4alpha1   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEMA4G promoter sequence
   Search SABiosciences Chromatin IP Primers for SEMA4G

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA4G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.31   Ensembl cytogenetic band:  10q24.31   HGNC cytogenetic band: 10q24.31

SEMA4G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA4G gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P102719:  view genomic region     (about GC identifiers)

Start:
102,729,275 bp from pter      End:
102,745,628 bp from pter
Size:
16,354 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SEM4G_HUMAN, Q9NTN9 (See protein sequence)
Recommended Name: Semaphorin-4G precursor  
Size: 838 amino acids; 91497 Da
Subunit: Interacts with PLXNB2 (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein
Sequence caution: Sequence=BAB13445.1; Type=Erroneous initiation;
Secondary accessions: A1A5C6 A6NJY8 Q58EY1 Q9HCF3
Alternative splicing: 3 isoforms:  Q9NTN9-1   Q9NTN9-2   Q9NTN9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEMA4G: NX_Q9NTN9

Explore proteomics data for SEMA4G at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NTN9

  • SEMA4G Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SEMA4G Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_060363.2  NP_001190173.1  

    ENSEMBL proteins: 
     ENSP00000428896   ENSP00000430881   ENSP00000430103   ENSP00000359270   ENSP00000430175  
     ENSP00000210633   ENSP00000429888  

    Human Recombinant Protein Products for SEMA4G: 
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    Novus Biologicals SEMA4G Proteins
    Novus Biologicals SEMA4G Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEMA4G 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    SEMA4G for ontologies           About GeneDecksing



    SEMA4G Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    SEMA: Semaphorins

    5/9 InterPro protein domains (see all 9):
     IPR007110 Ig-like_dom
     IPR003659 Plexin-like
     IPR003599 Ig_sub
     IPR002165 Plexin_repeat
     IPR016201 Plexin-like_fold

    Graphical View of Domain Structure for InterPro Entry Q9NTN9

    ProtoNet protein and cluster: Q9NTN9

    2 Blocks protein domains:
    IPB001627 Semaphorin/CD100 antigen
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: SEM4G_HUMAN, Q9NTN9
    Similarity: Belongs to the semaphorin family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 PSI domain
    Similarity: Contains 1 Sema domain


    SEMA4G for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEM4G_HUMAN, Q9NTN9
    Function: Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----
         
    SEMA4G for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sema4g):
     cellular  nervous system  normal 

    SEMA4G for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SEMA4G 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEMA4G 
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    miRNA
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    hsa-let-7d hsa-miR-1197 hsa-miR-1224-3p hsa-miR-106a hsa-miR-765 hsa-miR-938 hsa-miR-219-5p hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidSEMA4G 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SEMA4G About   (see all 13)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    3Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/54 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SEMA4G (see all 54)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer



    1         Kegg Pathway  (Kegg details for SEMA4G):
        Axon guidance


    SEMA4G for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEMA4G

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for SEMA4G (Q9NTN92, 3 ENSP000002106334) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIP13Q156452, 3, ENSP000001663454MINT-68011 I2D: score=4 STRING: ENSP00000166345
    DLG4P783523I2D: score=2 
    PLXNB1ENSP000002964404STRING: ENSP00000296440
    PLXNB2ENSP000003522884STRING: ENSP00000352288
    PLXNB3ENSP000003553784STRING: ENSP00000355378
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development ----
    GO:0007399nervous system development IEA--
    GO:0030154cell differentiation IEA--

    SEMA4G for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEMA4G (SEM4G)

    Search CenterWatch for drugs/clinical trials and news about SEMA4G / SEM4G

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SEMA4G gene (2 alternative transcripts): 
    NM_017893.3  NM_001203244.1  

    Unigene Cluster for SEMA4G:

    Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
    Hs.591923  [show with all ESTs]
    Unigene Representative Sequence: BC051030
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000519649 ENST00000521006(uc001krv.3 uc010qpt.1 uc001krx.3 uc001krw.2)
    ENST00000518124 ENST00000518244 ENST00000370250 ENST00000517724 ENST00000210633
    ENST00000519756 ENST00000518948 ENST00000476171 ENST00000484128

    miRNA
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    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA4G (see all 59):
    hsa-let-7d hsa-miR-1197 hsa-miR-1224-3p hsa-miR-106a hsa-miR-765 hsa-miR-938 hsa-miR-219-5p hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidSEMA4G 3' UTR sequence
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    Additional mRNA sequence: 

    AB046839.1 AK000597.1 AK297431.1 BC020960.1 BC051030.1 BC053507.1 BC068039.1 BC110382.1 
    BC128579.1 

    10 DOTS entries:

    DT.453396  DT.95098189  DT.121293586  DT.121293570  DT.91745137  DT.91745138  DT.95268102  DT.430205 
    DT.75126161  DT.97846895 

    24/81 AceView cDNA sequences (see all 81):

    BQ645660 NM_017893 AI016001 BC053507 BM672529 AI078359 BM769795 BC051030 
    BM769582 BC068039 AI651586 AI758186 BQ084390 AB046839 BC020960 BI519944 
    AI686177 AK000597 BQ083817 AA298655 BF802506 BE870613 AA706949 BI832371 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SEMA4G    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:              -     -     -                                       
    SP2:              -                                                   
    SP3:                                                                  
    SP4:                                                                  


    ECgene alternative splicing isoforms for SEMA4G

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEMA4G expression in normal human tissues (normalized intensities)      SEMA4G embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACAGAGTG
    SEMA4G Expression
    About this image


    SEMA4G expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Lower Urinary Tract (Urinary System)
             visceral organ/urethra of male   

    See SEMA4G Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEMA4G

    SOURCE GeneReport for Unigene cluster: Hs.591923
        SABiosciences Custom PCR Arrays for SEMA4G
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA4G
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA4G

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SEMA4G gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sema4g1 , 5 sema domain, immunoglobulin domain (Ig), transmembrane more1, 5 88.92(n)1
    91.27(a)1
      19 (38.16 cM)5
    264561  NM_011976.11  NP_036106.11 
     449891015 
    chicken
    (Gallus gallus)
    Aves SEMA4G6
    sema domain, immunoglobulin domain (Ig), transmemb...
    62(a)
    1 ↔ 1
    6(22627559-22632201)
    lizard
    (Anolis carolinensis)
    Reptilia SEMA4G6
    sema domain, immunoglobulin domain (Ig), transmemb...
    57(a)
    1 ↔ 1
    3(39307632-39473738)
    zebrafish
    (Danio rerio)
    Actinopterygii sema4g1 semaphorin 4g 57.61(n)
    54.44(a)
      563785  XM_001921388.2  XP_001921423.2 


    ENSEMBL Gene Tree for SEMA4G (if available)
    TreeFam Gene Tree for SEMA4G (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEMA4G gene
    SEMA3C2  SEMA4F2  SEMA3E2  SEMA4B2  SEMA4C2  SEMA3F2  SEMA4A2  SEMA4D2  
    SEMA3A2  SEMA3G2  SEMA3D2  
    15 SIMAP similar genes for SEMA4G using alignment to 5 protein entries:     SEM4G_HUMAN (see all proteins):
    SEMA4C    SEMA4D    SEMA3E    DKFZp686A04130    SEMA4D variant protein    SEMA4B
    SEMA3A    SEMA3D    SEMA4A    DKFZp686D04248    SEMA3C    SEMA4F
    SEMA3F    SEMA3B    SEMA5A

    SEMA4G for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/80 SNPs in SEMA4G are shown (see all 80)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1418649961,2
    C--102730287(+) GTCAGA/GAGCCT 2 -- us2k10--------
    rs720975491,2
    C--102730303(+) TCACC-/CAACACA 2 -- us2k10--------
    rs1167237321,2
    F--102730311(+) ACACAC/TACACA 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs353241661,2
    C--102730322(+) ACACA-/C/CA  
            
    ACCCC
    2 -- us2k11NA 2
    rs1910117781,2
    --102730329(+) CCCCCA/TCACCA 2 -- us2k10--------
    rs1178361171,2
    F--102730586(+) ATGGGT/CTTGTG 2 -- us2k11Minor allele frequency- C:0.01EA 120
    rs1388935621,2
    --102730627(+) TAGGAC/TCCTCC 2 -- us2k10--------
    rs1429149901,2
    --102730629(+) GGACCC/GTCCTG 2 -- us2k10--------
    rs1146236451,2
    F--102730714(+) ACCTGC/ATGAAT 2 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1147860021,2
    F--102730741(+) TCAACG/ATCACA 2 -- us2k11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for SEMA4G (102729275 - 102745628 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SEMA4G:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv517698CNV Loss19592680
    nsv467443CNV Loss19166990
    nsv895961CNV Loss21882294
    nsv831965CNV Loss17160897


    Human Gene Mutation Database (HGMD): SEMA4G
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SEMA4G
    DNA2.0 Custom Variant and Variant Library Synthesis for SEMA4G

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    5 diseases for SEMA4G:    About MalaCards
    renal cell carcinoma    alzheimer's disease    adenocarcinoma    pancreatitis
    breast cancer


    SEMA4G for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): SEMA4G
    Human Genome Epidemiology (HuGE) Navigator: SEMA4G (2 documents)

    Export disorders for SEMA4G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEMA4G gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with SEMA4G)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. (PubMed id 19047128)1, 4 Horikawa Y....Wu X. (2008)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    5. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (2000)
    6. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (2013)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    9. Semaphorin 4B interacts with the post-synaptic density protein PSD-95/SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif. (PubMed id 15978582)1 Burkhardt C....Puschel A.W. (2005)
    10. Semaphorin junction: making tracks toward neural connectivity. (PubMed id 12593985)1 Pasterkamp R.J. and Kolodkin A.L. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57715 HGNC: 10735 AceView: SEMA4G Ensembl:ENSG00000095539 euGenes: HUgn57715
    ECgene: SEMA4G Kegg: 57715 H-InvDB: SEMA4G

    (According to HUGE)
    About This Section
    HUGE: KIAA1619

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEMA4G Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEMA4G gene:
    Search GeneIP for patents involving SEMA4G

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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