Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SEMA4G Gene

protein-coding GIFtS: 55
GCID: GC10P102719

sema domain, immunoglobulin domain (Ig), transmembrane domain...

Explore 6 diseases affiliated with
SEMA4G via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4G¹ ²
KIAA1619¹ ³
FLJ20590¹
Semaphorin-4G¹

External Ids:	HGNC: 10735¹	Entrez Gene: 57715²	Ensembl: ENSG00000095539⁷	UniProtKB: Q9NTN9³

Export aliases for SEMA4G gene to outside databases

Previous GC identifers: GC10P101625 GC10P101966 GC10P102860 GC10P102396 GC10P096361

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEMA4G:

Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema)

domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based

on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and

2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via

multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding

different isoforms have been found for this gene. (provided by RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: SEM4G_HUMAN, Q9NTN9

Function: Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity)

Gene Wiki entry for SEMA4G

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SEMA4G gene promoter:
RFX1 p53 FOXO3 Lmo2 FOXD3 CUTL1 E47 FOXO3b HNF-4alpha1 FOXO3a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SEMA4G promoter sequence

Search SABiosciences Chromatin IP Primers for SEMA4G

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA4G

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.31 Ensembl cytogenetic band: 10q24.31 HGNC cytogenetic band: 10q24.31

SEMA4G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA4G gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P102719: view genomic region (about GC identifiers)

Start:	102,729,275 bp from pter	End:	102,745,628 bp from pter
Size:	16,354 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SEM4G_HUMAN, Q9NTN9 (See protein sequence)

Recommended Name: Semaphorin-4G precursor

Size: 838 amino acids; 91497 Da

Subunit: Interacts with PLXNB2 (By similarity)

Subcellular location: Cell membrane; Single-pass type I membrane protein

Sequence caution: Sequence=BAB13445.1; Type=Erroneous initiation;

Secondary accessions: A1A5C6 A6NJY8 Q58EY1 Q9HCF3

Alternative splicing: 3 isoforms: Q9NTN9-1 Q9NTN9-2 Q9NTN9-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEMA4G: NX_Q9NTN9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NTN9

SEMA4G Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_060363.2 NP_001190173.1

ENSEMBL proteins:

ENSP00000428896 ENSP00000430881 ENSP00000430103 ENSP00000359270 ENSP00000430175

ENSP00000210633 ENSP00000429888

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for SEMA4G (Semaphorin 4G)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for SEMA4G
	GenScript Custom Purified and Recombinant Proteins Services for SEMA4G
	Novus Biologicals SEMA4G Proteins Novus Biologicals SEMA4G Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SEMA4G

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

SEMA4G for ontologies About GeneDecksing

SEMA4G Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for SEMA4G (Semaphorin 4G)
	Browse OriGene Antibodies OriGene Custom Antibody Services for SEMA4G
	GenScript Custom Superior Antibodies Services for SEMA4G
	Novus Biologicals SEMA4G Antibodies
	Search for Antibodies for SEMA4G at Abcam
	Uscn Antibodies for SEMA4G
	Search ThermoFisher Antibodies for SEMA4G

Assay Products for SEMA4G:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SEMA4G
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SEMA4G

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SEMA4G for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR007110 Ig-like_dom

IPR003659 Plexin-like

IPR003599 Ig_sub

IPR002165 Plexin_repeat

IPR016201 Plexin-like_fold

Graphical View of Domain Structure for InterPro Entry Q9NTN9

ProtoNet protein and cluster: Q9NTN9

2 Blocks protein families:

IPB001627 Semaphorin/CD100 antigen

IPB003599 Immunoglobulin subtype

UniProtKB/Swiss-Prot: SEM4G_HUMAN, Q9NTN9

Similarity: Belongs to the semaphorin family

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

Similarity: Contains 1 PSI domain

Similarity: Contains 1 Sema domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SEM4G_HUMAN, Q9NTN9

Function: Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: SEMA4G Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA4G
		8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA4G (see all 59):
		hsa-let-7d hsa-miR-1197 hsa-miR-1224-3p hsa-miR-106a hsa-miR-765 hsa-miR-938 hsa-miR-219-5p hsa-let-7g

		SwitchGear 3'UTR luciferase reporter plasmid: SEMA4G 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA4G (see all 7) OriGene shRNA RFP: SEMA4G OriGene siRNA: SEMA4G
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA4G

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SEMA4G

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA4G (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA4G (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SEMA4G (NM_017893)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA4G
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA4G

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SEMA4G
		Search LifeMap BioReagents cell lines for SEMA4G

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA4G

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--

SEMA4G for ontologies About GeneDecksing

Animal Models:
3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Sema4g):

cellular

nervous system

normal

SEMA4G for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic Pathways in Synovial Fibroblasts

8/14 pathways (see all 14)
Apoptotic Pathways in Synovial Fibroblasts	1.00	ERK5 Signaling	0.61
p53 Mediated Apoptosis	0.84	eIF2 Pathway	0.60
Mitochondrial Apoptosis	0.73	Rac1 Pathway	0.58
Telomerase Components in Cell Signaling	0.72	Nuclear Receptor Activation by Vitamin-A	0.57

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

TGF-Beta Pathway

	TGF-Beta Pathway	1.00			JAK-STAT Pathway	0.57
	MAPK Family Pathway	0.60			JNK Pathway	0.50

Nanog in Mammalian ESC Pluripotency

	Nanog in Mammalian ESC Pluripotency	1.00			14-3-3 Induced Intracellular Signaling	0.59
	GSK3 Signaling	0.61			eNOS Signaling	0.48

Pathway sources
See GeneCards unified pathways
Show all pathways

5/54 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SEMA4G (see all 54)

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

1 Kegg Pathway (Kegg details for SEMA4G):

Axon guidance

SEMA4G for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SEMA4G

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for SEMA4G (Q9NTN9^{2, 3} ENSP00000210633⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRIP13	Q15645²^,³, ENSP00000166345⁴	MINT-68011 I2D: score=4 STRING: ENSP00000166345
DLG4	P78352³, ENSP00000293813⁴	I2D: score=2 STRING: ENSP00000293813
PLXNB1	ENSP00000296440⁴	STRING: ENSP00000296440
PLXNB2	ENSP00000352288⁴	STRING: ENSP00000352288
PLXNB3	ENSP00000355378⁴	STRING: ENSP00000355378

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007399	nervous system development	IEA	--
GO:0030154	cell differentiation	IEA	--

SEMA4G for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SEMA4G
Search CenterWatch for drugs/clinical trials and news about SEMA4G / SEM4G

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SEMA4G gene (2 alternative transcripts):

NM_017893.3 NM_001203244.1

Unigene Cluster for SEMA4G:

Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

Hs.591923 [show with all ESTs]

Unigene Representative Sequence: BC051030

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000519649 ENST00000521006(uc001krv.3 uc010qpt.1 uc001krx.3 uc001krw.2)

ENST00000518124 ENST00000518244 ENST00000370250 ENST00000517724 ENST00000210633

ENST00000519756 ENST00000518948 ENST00000476171 ENST00000484128

miRNA Products:		OriGene 3'-UTR Clone: SEMA4G Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA4G
		8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA4G (see all 59):
		hsa-let-7d hsa-miR-1197 hsa-miR-1224-3p hsa-miR-106a hsa-miR-765 hsa-miR-938 hsa-miR-219-5p hsa-let-7g

		SwitchGear 3'UTR luciferase reporter plasmid: SEMA4G 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA4G (see all 7) OriGene shRNA RFP: SEMA4G OriGene siRNA: SEMA4G
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA4G

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA4G (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA4G (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SEMA4G (NM_017893)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA4G
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA4G

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEMA4G Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SEMA4G
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA4G
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA4G

Additional cDNA sequence:

AB046839.1 AK000597.1 AK297431.1 BC020960.1 BC051030.1 BC053507.1 BC068039.1 BC110382.1

BC128579.1

10 DOTS entries:

DT.453396 DT.95098189 DT.121293586 DT.121293570 DT.91745137 DT.91745138 DT.95268102 DT.430205

DT.75126161 DT.97846895

24/81 AceView cDNA sequences (see all 81):

BC020960 BM672529 AI651586 AI758186 BM769795 AB046839 BQ645660 NM_017893

AI016001 BQ084390 BM769582 BC051030 BC068039 AI078359 BC053507 BI758458

BX331625 BI832371 BF802506 BG393055 BF345508 BI489946 AI686177 BX090089

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for SEMA4G About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b
SP1:					-		-		-
SP2:					-
SP3:
SP4:

ECgene alternative splicing isoforms for SEMA4G

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SEMA4G expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGACAGAGTG

About this image

SEMA4G expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SEMA4G Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEMA4G

SOURCE GeneReport for Unigene cluster: Hs.591923

SABiosciences Custom PCR Arrays for SEMA4G

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEMA4G Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SEMA4G
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA4G
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA4G

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA4G

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SEMA4G gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SEMA3F⁶	Uncharacterized protein	79(a)	1 ↔ 1	6(24518147-24519237)
lizard (Anolis carolinensis)	Reptilia	SEMA4G⁶ SEMA3F⁶	--	59(a) 30(a)	1 ↔ 1 possible ortholog	3(39310411-39346991) GL343512.1(1500-9205)
zebrafish (Danio rerio)	Actinopterygii	sema4g¹	semaphorin 4g	57.61(n) 54.44(a)		563785 XM_001921388.2 XP_001921423.2
fruit fly (Drosophila melanogaster)	Insecta	Sema-2a⁶ Sema-2b⁶	Semaphorin-2b	24(a) 21(a)	possible ortholog possible ortholog	2R(12387701-12420934) 2R(12274029-12319263)
worm (Caenorhabditis elegans)	Secernentea	mab-20⁶ smp-2⁶	SeMaPhorin related family member (smp-2)	20(a) 19(a)	possible ortholog possible ortholog	I(1644590-1651382) I(3667127-3671705)

ENSEMBL Gene Tree for SEMA4G (if available)
TreeFam Gene Tree for SEMA4G (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SEMA4G gene

SEMA3C² SEMA4F² SEMA3E² SEMA4B² SEMA3F² SEMA4C² SEMA4A² SEMA4D²

SEMA3A² SEMA3G² SEMA3D²

15 SIMAP similar genes for SEMA4G using alignment to 5 protein entries: SEM4G_HUMAN (see all proteins):

SEMA4C SEMA4D SEMA3E DKFZp686A04130 SEMA4D variant protein SEMA4B

SEMA3A SEMA3D SEMA4A DKFZp686D04248 SEMA3C SEMA4F

SEMA3F SEMA3B SEMA5A

SEMA4G for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141864996^1,2		--	102730287(+)	`GTCAGA/GAGCCT`	2	--	us2k¹		0	--	--	--	--
rs148450832^1,2	C,	--	102730300(+)	`ATCAC-/CACACAC`	2	--	us2k¹		0	--	--	--	--
rs116723732^1,2		--	102730311(+)	`ACACAC/TACACA`	2	--	us2k¹		1		WA	118
rs191011778^1,2		--	102730329(+)	`CCCCCA/TCACCA`	2	--	us2k¹		0	--	--	--	--
rs117836117^1,2		--	102730586(+)	`ATGGGT/CTTGTG`	2	--	us2k¹		1		EA	120
rs138893562^1,2		--	102730627(+)	`TAGGAC/TCCTCC`	2	--	us2k¹		0	--	--	--	--
rs142914990^1,2		--	102730629(+)	`GGACCC/GTCCTG`	2	--	us2k¹		0	--	--	--	--
rs114623645^1,2	F,	--	102730714(+)	`ACCTGC/ATGAAT`	2	--	us2k¹		1		WA	118
rs114786002^1,2		--	102730741(+)	`TCAACG/ATCACA`	2	--	us2k¹		1		WA	118
rs138143302^1,2		--	102730784(+)	`CCTCTC/GTATGA`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SEMA4G (102729275 - 102745628 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SEMA4G
1 CNV: 4711
Human Gene Mutation Database (HGMD): SEMA4G

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEMA4G

DNA2.0 Custom Variant and Variant Library Synthesis for SEMA4G

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SEMA4G for disorders About GeneDecksing

6 diseases for SEMA4G: About MalaCards

renal cell carcinoma alzheimer's disease carcinoma breast cancer

adenocarcinoma pancreatitis

Human Genome Epidemiology (HuGE) Navigator: SEMA4G (2 documents)

Export disorders for SEMA4G gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SEMA4G gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with SEMA4G)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{1, 2} Deloukas P.... Rogers J. (2004)
Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)^{1, 2} Nagase T.... Ohara O. (2000)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (2012)
Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. (PubMed id 19047128)¹ Horikawa Y....Wu X. (2008)
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)¹ Grupe A....Goate A. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)
Semaphorin 4B interacts with the post-synaptic density protein PSD-95/SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif. (PubMed id 15978582)¹ Burkhardt C....Puschel A.W. (2005)
Semaphorin junction: making tracks toward neural connectivity. (PubMed id 12593985)¹ Pasterkamp R.J. and Kolodkin A.L. (2003)
Molecular mechanisms of axon guidance. (PubMed id 12471249)¹ Dickson B.J. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 57715	HGNC: 10735	AceView: SEMA4G	Ensembl:ENSG00000095539	euGenes: HUgn57715
ECgene: SEMA4G	Kegg: 57715	H-InvDB: SEMA4G

(According to HUGE)
About This Section

HUGE: KIAA1619

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SEMA4G	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SEMA4G gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SEMA4G gene:
Search GeneIP for patents involving SEMA4G

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for SEMA4G (Semaphorin 4G)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for SEMA4G (Semaphorin 4G)

	Browse OriGene Antibodies		OriGene shRNA RFP for SEMA4G
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA4G		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEMA4G
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SEMA4G		OriGene 3'-UTR Clone for SEMA4G
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA4G		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA4G
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SEMA4G		OriGene Custom Protein Services for SEMA4G
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SEMA4G
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEMA4G
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA4G
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA4G
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA4G
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA4G

	GenScript Custom Purified and Recombinant Proteins Services for SEMA4G		GenScript cDNA clones with any tag delivered in your preferred vector for SEMA4G
	GenScript Custom Assay Services for SEMA4G		GenScript Custom Superior Antibodies Services for SEMA4G
	GenScript Custom overexpressing Cell Line Services for SEMA4G		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in SEMA4G promoter
	Search Chromatin IP Primers for SEMA4G
	RT² qPCR Primer Assay in human, mouse, rat SEMA4G
	Search GNC Networks for SEMA4G
	SABiosciences PCR Arrays including human, mouse, rat SEMA4G

Search Tocris compounds for SEMA4G

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SEMA4G antibodies
	SEMA4G proteins
	SEMA4G lysates

	Search for Antibodies for SEMA4G at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for SEMA4G
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

SEMA4G Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for SEMA4G

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA4G

	SwitchGear 3'UTR luciferase reporter plasmids for SEMA4G
	SwitchGear Promoter luciferase reporter plasmids for SEMA4G

Search ThermoFisher Antibodies for SEMA4G

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA4G

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SEMA4G gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

SEMA4G Gene

sema domain, immunoglobulin domain (Ig), transmembrane domain...

Aliases
for SEMA4G gene

Summaries
for SEMA4G gene

Genomic Views
for SEMA4G gene

Proteins
for SEMA4G gene

Protein Domains /
Families
for SEMA4G gene

Function
for SEMA4G gene

Pathways & Interactions
for SEMA4G gene

Drugs & Compounds
for SEMA4G gene

Transcripts
for SEMA4G gene

Expression
for SEMA4G gene

Orthologs
for SEMA4G gene

Paralogs
for SEMA4G gene

Genomic Variants
for SEMA4G gene

Disorders / Diseases
for SEMA4G gene

Publications
for SEMA4G gene

External Searches for SEMA4G gene

Genome Databases showing SEMA4G gene

Other Databases showing SEMA4G gene

Specialized Databases showing SEMA4G gene

Intellectual Property
for SEMA4G gene

Products
for SEMA4G gene

View Random Gene

Advanced Search

Export list of displayed genes

SEMA4G Gene

sema domain, immunoglobulin domain (Ig), transmembrane domain...

Aliasesfor SEMA4G gene

Summariesfor SEMA4G gene

Genomic Viewsfor SEMA4G gene

Proteinsfor SEMA4G gene

Protein Domains /Familiesfor SEMA4G gene

Functionfor SEMA4G gene

Pathways & Interactionsfor SEMA4G gene

Drugs & Compoundsfor SEMA4G gene

Transcriptsfor SEMA4G gene

Expression for SEMA4G gene

Orthologsfor SEMA4G gene

Paralogsfor SEMA4G gene

Genomic Variantsfor SEMA4G gene

Disorders / Diseasesfor SEMA4G gene

Publicationsfor SEMA4G gene

External Searches for SEMA4G gene

Genome Databases showing SEMA4G gene

Other Databases showing SEMA4G gene

Specialized Databases showing SEMA4G gene

Intellectual Propertyfor SEMA4G gene

Productsfor SEMA4G gene

View Random Gene

Aliases
for SEMA4G gene

Summaries
for SEMA4G gene

Genomic Views
for SEMA4G gene

Proteins
for SEMA4G gene

Protein Domains /
Families
for SEMA4G gene

Function
for SEMA4G gene

Pathways & Interactions
for SEMA4G gene

Drugs & Compounds
for SEMA4G gene

Transcripts
for SEMA4G gene

Expression
for SEMA4G gene

Orthologs
for SEMA4G gene

Paralogs
for SEMA4G gene

Genomic Variants
for SEMA4G gene

Disorders / Diseases
for SEMA4G gene

Publications
for SEMA4G gene

Intellectual Property
for SEMA4G gene

Products
for SEMA4G gene