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SEMA4G Gene(Protein Coding)

Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4G

Aliases for SEMA4G Gene

Aliases for SEMA4G Gene

  • Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4G 2 3
  • Semaphorin-4G 3
  • KIAA1619 4

External Ids for SEMA4G Gene

Summaries for SEMA4G Gene

Entrez Gene Summary for SEMA4G Gene

  • Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for SEMA4G Gene

SEMA4G (Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4G) is a Protein Coding gene. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA3F.

UniProtKB/Swiss-Prot for SEMA4G Gene

  • Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity).

Gene Wiki entry for SEMA4G Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMA4G Gene

Genomics for SEMA4G Gene

Genomic Location for SEMA4G Gene

100,969,497 bp from pter
100,985,871 bp from pter
16,375 bases
Plus strand

Genomic View for SEMA4G Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEMA4G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA4G Gene

Regulatory Elements for SEMA4G Gene

Proteins for SEMA4G Gene

  • Protein details for SEMA4G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A1A5C6
    • A6NJY8
    • Q58EY1
    • Q9HCF3

    Protein attributes for SEMA4G Gene

    838 amino acids
    Molecular mass:
    91497 Da
    Quaternary structure:
    • Interacts with PLXNB2.
    • Sequence=BAB13445.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SEMA4G Gene


neXtProt entry for SEMA4G Gene

Proteomics data for SEMA4G Gene at MOPED

Post-translational modifications for SEMA4G Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn55, Asn111, Asn126, Asn388, Asn542, and Asn598

No data available for DME Specific Peptides for SEMA4G Gene

Domains for SEMA4G Gene

Gene Families for SEMA4G Gene

  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • SEMA :Semaphorins


  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.:
    • Q9NTN9
  • Contains 1 PSI domain.:
    • Q9NTN9
  • Contains 1 Sema domain.:
    • Q9NTN9
  • Belongs to the semaphorin family.:
    • Q9NTN9
genes like me logo Genes that share domains with SEMA4G: view

Function for SEMA4G Gene

Molecular function for SEMA4G Gene

UniProtKB/Swiss-Prot Function: Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity).

Gene Ontology (GO) - Molecular Function for SEMA4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SEMA4G: view

Phenotypes for SEMA4G Gene

genes like me logo Genes that share phenotypes with SEMA4G: view

miRNA for SEMA4G Gene

miRTarBase miRNAs that target SEMA4G

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEMA4G Gene

Localization for SEMA4G Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA4G Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for SEMA4G Gene COMPARTMENTS Subcellular localization image for SEMA4G gene
Compartment Confidence
plasma membrane 5
cytosol 1
extracellular 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SEMA4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SEMA4G: view

Pathways for SEMA4G Gene

genes like me logo Genes that share pathways with SEMA4G: view

Pathways by source for SEMA4G Gene

Gene Ontology (GO) - Biological Process for SEMA4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development --
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SEMA4G: view

Transcripts for SEMA4G Gene

Unigene Clusters for SEMA4G Gene

Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA4G Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - - -
SP2: -

Relevant External Links for SEMA4G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEMA4G Gene

mRNA expression in normal human tissues for SEMA4G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEMA4G Gene

This gene is overexpressed in Colon - Transverse (7.0) and Liver (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SEMA4G Gene

SOURCE GeneReport for Unigene cluster for SEMA4G Gene Hs.591923

genes like me logo Genes that share expressions with SEMA4G: view

Orthologs for SEMA4G Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEMA4G Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SEMA4G 36
  • 90 (n)
  • 92.53 (a)
  • 93 (a)
(Canis familiaris)
Mammalia SEMA4G 36
  • 89.71 (n)
  • 92.97 (a)
  • 93 (a)
(Mus musculus)
Mammalia Sema4g 36
  • 88.56 (n)
  • 90.55 (a)
Sema4g 16
Sema4g 37
  • 91 (a)
(Monodelphis domestica)
Mammalia SEMA4G 37
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia SEMA4G 37
  • 66 (a)
(Rattus norvegicus)
Mammalia Sema4g 36
  • 88.92 (n)
  • 91.99 (a)
(Gallus gallus)
Aves SEMA4G 37
  • 63 (a)
(Anolis carolinensis)
Reptilia SEMA4G 37
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sema4g 36
  • 58.07 (n)
  • 56.8 (a)
(Danio rerio)
Actinopterygii SEMA4G (2 of 2) 37
  • 48 (a)
sema4ga 36
  • 56.98 (n)
  • 53.08 (a)
sema4ga 37
  • 49 (a)
Species with no ortholog for SEMA4G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEMA4G Gene

Gene Tree for SEMA4G (if available)
Gene Tree for SEMA4G (if available)

Paralogs for SEMA4G Gene

genes like me logo Genes that share paralogs with SEMA4G: view

Variants for SEMA4G Gene

Sequence variations from dbSNP and Humsavar for SEMA4G Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs735137 -- 100,976,078(-) CCCCC(C/G)TCTCC intron-variant
rs1570171 -- 100,972,002(-) TGCAC(A/T)TCTCT upstream-variant-2KB, intron-variant
rs7091358 -- 100,976,429(+) tgcag(A/C)ctcga intron-variant
rs7918869 -- 100,976,862(+) AAGTC(A/G)TTTTT intron-variant
rs9888046 -- 100,969,406(+) GAGAG(C/T)GGCGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SEMA4G Gene

Variant ID Type Subtype PubMed ID
nsv831965 CNV Loss 17160897
nsv467443 CNV Loss 19166990
nsv517698 CNV Loss 19592680
nsv895961 CNV Loss 21882294

Relevant External Links for SEMA4G Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for SEMA4G Gene

Relevant External Links for SEMA4G

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SEMA4G: view

No data available for UniProtKB/Swiss-Prot for SEMA4G Gene

Publications for SEMA4G Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 49
  5. Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. (PMID: 19047128) Horikawa Y. … Wu X. (Clin. Cancer Res. 2008) 3 49

Products for SEMA4G Gene

Sources for SEMA4G Gene

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