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Aliases for SEMA4G Gene

Aliases for SEMA4G Gene

  • Semaphorin 4G 2 3 5
  • Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4G 2 3
  • Semaphorin-4G 3
  • KIAA1619 4

External Ids for SEMA4G Gene

Previous GeneCards Identifiers for SEMA4G Gene

  • GC10P101625
  • GC10P101966
  • GC10P102860
  • GC10P102396
  • GC10P102719
  • GC10P096361
  • GC10P102729

Summaries for SEMA4G Gene

Entrez Gene Summary for SEMA4G Gene

  • Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for SEMA4G Gene

SEMA4G (Semaphorin 4G) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and GPCR Pathway. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA4C.

UniProtKB/Swiss-Prot for SEMA4G Gene

  • Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity).

Gene Wiki entry for SEMA4G Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMA4G Gene

Genomics for SEMA4G Gene

Regulatory Elements for SEMA4G Gene

Enhancers for SEMA4G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F100995 1 ENCODE 12.4 +29.8 29823 7.4 HDGF ZFP64 ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ENSG00000231188 TPM4P1 SPCS2P2 MRPL43 SEMA4G MIR608 ENSG00000272572 KCNIP2 LZTS2 PDZD7
GH10F100939 0.7 ENCODE 11.9 -29.5 -29504 0.2 PRDM1 SEMA4G SLF2 MIR608 ENSG00000236662 MRPL43 TWNK ENSG00000272572 ENSG00000273476
GH10F100909 0.8 Ensembl ENCODE 10.7 -57.6 -57587 5.0 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 MRPL43 TWNK ENSG00000272572 CHUK SEMA4G MIR608 SLF2 ENSG00000222072
GH10F100900 0.6 ENCODE 10.5 -68.1 -68129 1.4 ELF3 HDGF MLX ZFP64 ARID4B KLF17 RAD21 ZNF48 SLC30A9 GLIS2 SEMA4G ENSG00000236662 MRPL43 TWNK SLF2 ENSG00000222072 GC10P100864
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SEMA4G on UCSC Golden Path with GeneCards custom track

Promoters for SEMA4G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000360520 118 1601 ARID4B DMAP1 ZNF2 ZNF48 GLIS2 ZNF143 SP3 SP5 REST PPARG

Genomic Location for SEMA4G Gene

100,969,482 bp from pter
100,985,871 bp from pter
16,390 bases
Plus strand

Genomic View for SEMA4G Gene

Genes around SEMA4G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEMA4G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEMA4G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA4G Gene

Proteins for SEMA4G Gene

  • Protein details for SEMA4G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A1A5C6
    • A6NJY8
    • Q58EY1
    • Q9HCF3

    Protein attributes for SEMA4G Gene

    838 amino acids
    Molecular mass:
    91497 Da
    Quaternary structure:
    • Interacts with PLXNB2.
    • Sequence=BAB13445.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SEMA4G Gene


neXtProt entry for SEMA4G Gene

Post-translational modifications for SEMA4G Gene

  • Glycosylation at Asn 55, Asn 111, Asn 126, Asn 388, Asn 542, and Asn 598
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SEMA4G Gene

Domains & Families for SEMA4G Gene

Suggested Antigen Peptide Sequences for SEMA4G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Belongs to the semaphorin family.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 PSI domain.
  • Contains 1 Sema domain.
  • Belongs to the semaphorin family.
genes like me logo Genes that share domains with SEMA4G: view

Function for SEMA4G Gene

Molecular function for SEMA4G Gene

UniProtKB/Swiss-Prot Function:
Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity).

Gene Ontology (GO) - Molecular Function for SEMA4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0030215 semaphorin receptor binding IBA --
GO:0038191 NOT neuropilin binding IBA --
GO:0045499 chemorepellent activity IBA --
genes like me logo Genes that share ontologies with SEMA4G: view
genes like me logo Genes that share phenotypes with SEMA4G: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SEMA4G

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEMA4G Gene

Localization for SEMA4G Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA4G Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for SEMA4G Gene COMPARTMENTS Subcellular localization image for SEMA4G gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytosol 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SEMA4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SEMA4G: view

Pathways & Interactions for SEMA4G Gene

genes like me logo Genes that share pathways with SEMA4G: view

Gene Ontology (GO) - Biological Process for SEMA4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001755 neural crest cell migration IBA --
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
GO:0030335 positive regulation of cell migration IBA --
genes like me logo Genes that share ontologies with SEMA4G: view

No data available for SIGNOR curated interactions for SEMA4G Gene

Transcripts for SEMA4G Gene

Unigene Clusters for SEMA4G Gene

Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA4G Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - - -
SP2: -

Relevant External Links for SEMA4G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEMA4G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SEMA4G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEMA4G Gene

This gene is overexpressed in Colon - Transverse (x7.0) and Liver (x5.7).

Protein differential expression in normal tissues from HIPED for SEMA4G Gene

This gene is overexpressed in Rectum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SEMA4G Gene

Protein tissue co-expression partners for SEMA4G Gene

NURSA nuclear receptor signaling pathways regulating expression of SEMA4G Gene:


SOURCE GeneReport for Unigene cluster for SEMA4G Gene:

genes like me logo Genes that share expression patterns with SEMA4G: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SEMA4G Gene

Orthologs for SEMA4G Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEMA4G Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SEMA4G 34 35
  • 90 (n)
(Canis familiaris)
Mammalia SEMA4G 34 35
  • 89.71 (n)
(Rattus norvegicus)
Mammalia Sema4g 34
  • 88.92 (n)
(Mus musculus)
Mammalia Sema4g 34 16 35
  • 88.56 (n)
(Monodelphis domestica)
Mammalia SEMA4G 35
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia SEMA4G 35
  • 66 (a)
(Gallus gallus)
Aves SEMA4G 35
  • 63 (a)
(Anolis carolinensis)
Reptilia SEMA4G 35
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sema4g 34
  • 58.07 (n)
(Danio rerio)
Actinopterygii sema4ga 34 35
  • 56.98 (n)
SEMA4G (2 of 2) 35
  • 48 (a)
Species where no ortholog for SEMA4G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEMA4G Gene

Gene Tree for SEMA4G (if available)
Gene Tree for SEMA4G (if available)

Paralogs for SEMA4G Gene

genes like me logo Genes that share paralogs with SEMA4G: view

Variants for SEMA4G Gene

Sequence variations from dbSNP and Humsavar for SEMA4G Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10563529 -- 100,971,117(+) GAACA(-/TG)TGTGT intron-variant, upstream-variant-2KB
rs1058101 -- 100,985,134(+) TCTTT(G/T)GGGGA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs10748803 -- 100,981,915(+) tagcc(A/G)ggtgt intron-variant
rs111375222 -- 100,981,796(+) CTCAC(A/G)CCTGT intron-variant
rs111542775 -- 100,980,795(+) GCTGC(A/C/T)GACCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEMA4G Gene

Variant ID Type Subtype PubMed ID
esv3624366 CNV loss 21293372
nsv467443 CNV loss 19166990
nsv517698 CNV loss 19592680
nsv552051 CNV loss 21841781
nsv831965 CNV loss 17160897

Variation tolerance for SEMA4G Gene

Residual Variation Intolerance Score: 61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEMA4G Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEMA4G Gene

Disorders for SEMA4G Gene

Relevant External Links for SEMA4G

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SEMA4G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEMA4G Gene

Publications for SEMA4G Gene

  1. Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. (PMID: 19047128) Horikawa Y. … Wu X. (Clin. Cancer Res. 2008) 3 46 64
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64

Products for SEMA4G Gene

Sources for SEMA4G Gene

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