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Aliases for SEMA4G Gene

Aliases for SEMA4G Gene

  • Semaphorin 4G 2 3 5
  • Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4G 2 3
  • Semaphorin-4G 3
  • KIAA1619 4

External Ids for SEMA4G Gene

Previous GeneCards Identifiers for SEMA4G Gene

  • GC10P101625
  • GC10P101966
  • GC10P102860
  • GC10P102396
  • GC10P102719
  • GC10P096361
  • GC10P102729

Summaries for SEMA4G Gene

Entrez Gene Summary for SEMA4G Gene

  • Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for SEMA4G Gene

SEMA4G (Semaphorin 4G) is a Protein Coding gene. Among its related pathways are p70S6K Signaling and Akt Signaling. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA4C.

UniProtKB/Swiss-Prot for SEMA4G Gene

  • Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity).

Gene Wiki entry for SEMA4G Gene

Additional gene information for SEMA4G Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMA4G Gene

Genomics for SEMA4G Gene

Regulatory Elements for SEMA4G Gene

Enhancers for SEMA4G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H100995 1.4 ENCODE dbSUPER 12.4 +29.8 29823 7.4 HDGF ZFP64 ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ENSG00000231188 TPM4P1 SPCS2P2 MRPL43 SEMA4G MIR608 ENSG00000272572 KCNIP2 LZTS2 PDZD7
GH10H100909 1.6 Ensembl ENCODE dbSUPER 10.7 -57.5 -57518 4.8 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 MRPL43 TWNK ENSG00000272572 CHUK SEMA4G MIR608 CWF19L1 POLL SLF2 ENSG00000222072
GH10H100535 1.1 ENCODE 9.2 -433.5 -433546 1.6 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF207 ZNF143 SEC31B PHBP9 CWF19L1 SLC25A28 MRPL43 SLF2 SEMA4G HIF1AN NDUFB8 ENSG00000274660
GH10H101028 0.9 ENCODE dbSUPER 10.3 +59.8 59794 1.1 CTCF MAZ ZNF3 ZIC2 RARA TEAD3 GATA3 POLR2A PRDM10 CHD2 MRPL43 TWNK ENSG00000236662 SEMA4G PDZD7 LZTS2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SEMA4G on UCSC Golden Path with GeneCards custom track

Promoters for SEMA4G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000032557 218 1001 RB1 ARID4B DMAP1 RAD21 ZNF2 YY1 GLIS2 ZNF143 CREM MIXL1

Genomic Locations for SEMA4G Gene

Genomic Locations for SEMA4G Gene
16,390 bases
Plus strand

Genomic View for SEMA4G Gene

Genes around SEMA4G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEMA4G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEMA4G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA4G Gene

Proteins for SEMA4G Gene

  • Protein details for SEMA4G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A1A5C6
    • A6NJY8
    • Q58EY1
    • Q9HCF3

    Protein attributes for SEMA4G Gene

    838 amino acids
    Molecular mass:
    91497 Da
    Quaternary structure:
    • Interacts with PLXNB2.
    • Sequence=BAB13445.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SEMA4G Gene


neXtProt entry for SEMA4G Gene

Post-translational modifications for SEMA4G Gene

  • Glycosylation at isoforms=2, 355, isoforms=2, 3111, Asn126, Asn388, isoforms=2, 3542, and isoforms=2598
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SEMA4G Gene

Domains & Families for SEMA4G Gene

Gene Families for SEMA4G Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for SEMA4G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the semaphorin family.
  • Belongs to the semaphorin family.
genes like me logo Genes that share domains with SEMA4G: view

Function for SEMA4G Gene

Molecular function for SEMA4G Gene

UniProtKB/Swiss-Prot Function:
Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity).

Phenotypes From GWAS Catalog for SEMA4G Gene

Gene Ontology (GO) - Molecular Function for SEMA4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0038191 NOT neuropilin binding IBA --
genes like me logo Genes that share ontologies with SEMA4G: view
genes like me logo Genes that share phenotypes with SEMA4G: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEMA4G Gene

Localization for SEMA4G Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA4G Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEMA4G gene
Compartment Confidence
plasma membrane 5
extracellular 4
mitochondrion 1
peroxisome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SEMA4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SEMA4G: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SEMA4G Gene

Pathways & Interactions for SEMA4G Gene

genes like me logo Genes that share pathways with SEMA4G: view

Gene Ontology (GO) - Biological Process for SEMA4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
GO:0050919 negative chemotaxis IBA --
genes like me logo Genes that share ontologies with SEMA4G: view

No data available for SIGNOR curated interactions for SEMA4G Gene

Drugs & Compounds for SEMA4G Gene

No Compound Related Data Available

Transcripts for SEMA4G Gene

Unigene Clusters for SEMA4G Gene

Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA4G Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - - -
SP2: -

Relevant External Links for SEMA4G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEMA4G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEMA4G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEMA4G Gene

This gene is overexpressed in Colon - Transverse (x7.0) and Liver (x5.7).

Protein differential expression in normal tissues from HIPED for SEMA4G Gene

This gene is overexpressed in Rectum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SEMA4G Gene

Protein tissue co-expression partners for SEMA4G Gene

NURSA nuclear receptor signaling pathways regulating expression of SEMA4G Gene:


SOURCE GeneReport for Unigene cluster for SEMA4G Gene:


Evidence on tissue expression from TISSUES for SEMA4G Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SEMA4G: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEMA4G Gene

Orthologs for SEMA4G Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEMA4G Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SEMA4G 33 34
  • 90 (n)
(Canis familiaris)
Mammalia SEMA4G 33 34
  • 89.71 (n)
(Rattus norvegicus)
Mammalia Sema4g 33
  • 88.92 (n)
(Mus musculus)
Mammalia Sema4g 33 16 34
  • 88.56 (n)
(Monodelphis domestica)
Mammalia SEMA4G 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia SEMA4G 34
  • 66 (a)
(Gallus gallus)
Aves SEMA4G 34
  • 63 (a)
(Anolis carolinensis)
Reptilia SEMA4G 34
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sema4g 33
  • 58.07 (n)
(Danio rerio)
Actinopterygii sema4ga 33 34
  • 56.98 (n)
SEMA4G (2 of 2) 34
  • 48 (a)
Species where no ortholog for SEMA4G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEMA4G Gene

Gene Tree for SEMA4G (if available)
Gene Tree for SEMA4G (if available)

Paralogs for SEMA4G Gene

genes like me logo Genes that share paralogs with SEMA4G: view

Variants for SEMA4G Gene

Sequence variations from dbSNP and Humsavar for SEMA4G Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000038219 -- 100,976,030(+) GGCTG(A/G)GGGCA intron-variant
rs1000263318 -- 100,980,496(+) TCCTG(A/G)GCTGT intron-variant
rs1000336668 -- 100,969,778(+) GCGGG(A/G)TGCAA intron-variant, nc-transcript-variant
rs1000469814 -- 100,986,024(+) ACATG(G/T)ATTTT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1001397510 -- 100,968,114(+) AAAAT(G/T)AAGCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SEMA4G Gene

Variant ID Type Subtype PubMed ID
nsv831965 CNV loss 17160897
nsv552051 CNV loss 21841781
nsv517698 CNV loss 19592680
nsv467443 CNV loss 19166990
esv3624366 CNV loss 21293372

Variation tolerance for SEMA4G Gene

Residual Variation Intolerance Score: 61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEMA4G Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEMA4G Gene

Disorders for SEMA4G Gene

Relevant External Links for SEMA4G

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SEMA4G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEMA4G Gene

Publications for SEMA4G Gene

  1. Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. (PMID: 19047128) Horikawa Y … Wu X (Clinical cancer research : an official journal of the American Association for Cancer Research 2008) 3 45 60
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 45 60
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 60

Products for SEMA4G Gene

Sources for SEMA4G Gene

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