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Aliases for SEMA4G Gene

Aliases for SEMA4G Gene

  • Semaphorin 4G 2 3
  • Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4G 2 5
  • KIAA1619 4

External Ids for SEMA4G Gene

Previous GeneCards Identifiers for SEMA4G Gene

  • GC10P101625
  • GC10P101966
  • GC10P102860
  • GC10P102396
  • GC10P102719
  • GC10P096361
  • GC10P102729

Summaries for SEMA4G Gene

Entrez Gene Summary for SEMA4G Gene

  • Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for SEMA4G Gene

SEMA4G (Semaphorin 4G) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA3F.

UniProtKB/Swiss-Prot for SEMA4G Gene

  • Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity).

Gene Wiki entry for SEMA4G Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMA4G Gene

Genomics for SEMA4G Gene

Regulatory Elements for SEMA4G Gene

Promoters for SEMA4G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SEMA4G on UCSC Golden Path with GeneCards custom track

Genomic Location for SEMA4G Gene

Chromosome:
10
Start:
100,969,482 bp from pter
End:
100,985,871 bp from pter
Size:
16,390 bases
Orientation:
Plus strand

Genomic View for SEMA4G Gene

Genes around SEMA4G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEMA4G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEMA4G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA4G Gene

Proteins for SEMA4G Gene

  • Protein details for SEMA4G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTN9-SEM4G_HUMAN
    Recommended name:
    Semaphorin-4G
    Protein Accession:
    Q9NTN9
    Secondary Accessions:
    • A1A5C6
    • A6NJY8
    • Q58EY1
    • Q9HCF3

    Protein attributes for SEMA4G Gene

    Size:
    838 amino acids
    Molecular mass:
    91497 Da
    Quaternary structure:
    • Interacts with PLXNB2.
    SequenceCaution:
    • Sequence=BAB13445.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SEMA4G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEMA4G Gene

Proteomics data for SEMA4G Gene at MOPED

Post-translational modifications for SEMA4G Gene

  • Glycosylation at Asn 55, Asn 111, Asn 126, Asn 388, Asn 542, and Asn 598
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for SEMA4G (Semaphorin 4G)

No data available for DME Specific Peptides for SEMA4G Gene

Domains & Families for SEMA4G Gene

Suggested Antigen Peptide Sequences for SEMA4G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NTN9

UniProtKB/Swiss-Prot:

SEM4G_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Belongs to the semaphorin family.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 PSI domain.
  • Contains 1 Sema domain.
Family:
  • Belongs to the semaphorin family.
genes like me logo Genes that share domains with SEMA4G: view

Function for SEMA4G Gene

Molecular function for SEMA4G Gene

UniProtKB/Swiss-Prot Function:
Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity).
genes like me logo Genes that share phenotypes with SEMA4G: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEMA4G Gene

Localization for SEMA4G Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA4G Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEMA4G Gene COMPARTMENTS Subcellular localization image for SEMA4G gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytosol 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SEMA4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SEMA4G: view

Pathways & Interactions for SEMA4G Gene

genes like me logo Genes that share pathways with SEMA4G: view

Pathways by source for SEMA4G Gene

Gene Ontology (GO) - Biological Process for SEMA4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030335 positive regulation of cell migration IBA --
genes like me logo Genes that share ontologies with SEMA4G: view

No data available for SIGNOR curated interactions for SEMA4G Gene

Drugs & Compounds for SEMA4G Gene

No Compound Related Data Available

Transcripts for SEMA4G Gene

Unigene Clusters for SEMA4G Gene

Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA4G Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - - -
SP2: -
SP3:
SP4:

Relevant External Links for SEMA4G Gene

GeneLoc Exon Structure for
SEMA4G
ECgene alternative splicing isoforms for
SEMA4G

Expression for SEMA4G Gene

mRNA expression in normal human tissues for SEMA4G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEMA4G Gene

This gene is overexpressed in Colon - Transverse (x7.0) and Liver (x5.7).

Protein differential expression in normal tissues from HIPED for SEMA4G Gene

This gene is overexpressed in Rectum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SEMA4G Gene



SOURCE GeneReport for Unigene cluster for SEMA4G Gene Hs.591923

genes like me logo Genes that share expression patterns with SEMA4G: view

Protein tissue co-expression partners for SEMA4G Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SEMA4G Gene

Orthologs for SEMA4G Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEMA4G Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SEMA4G 35
  • 90 (n)
  • 92.53 (a)
SEMA4G 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEMA4G 35
  • 89.71 (n)
  • 92.97 (a)
SEMA4G 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sema4g 35
  • 88.56 (n)
  • 90.55 (a)
Sema4g 16
Sema4g 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sema4g 35
  • 88.92 (n)
  • 91.99 (a)
oppossum
(Monodelphis domestica)
Mammalia SEMA4G 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEMA4G 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEMA4G 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEMA4G 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sema4g 35
  • 58.07 (n)
  • 56.8 (a)
zebrafish
(Danio rerio)
Actinopterygii sema4ga 35
  • 56.98 (n)
  • 53.08 (a)
SEMA4G (2 of 2) 36
  • 48 (a)
OneToMany
sema4ga 36
  • 49 (a)
OneToMany
Species with no ortholog for SEMA4G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEMA4G Gene

ENSEMBL:
Gene Tree for SEMA4G (if available)
TreeFam:
Gene Tree for SEMA4G (if available)

Paralogs for SEMA4G Gene

genes like me logo Genes that share paralogs with SEMA4G: view

Variants for SEMA4G Gene

Sequence variations from dbSNP and Humsavar for SEMA4G Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs735137 -- 100,976,078(-) CCCCC(A/C/G)TCTCC intron-variant
rs1570171 -- 100,972,002(-) TGCAC(A/T)TCTCT intron-variant, upstream-variant-2KB
rs7091358 -- 100,976,429(+) tgcag(A/C)ctcga intron-variant
rs7918869 -- 100,976,862(+) AAGTC(A/G)TTTTT intron-variant
rs9888046 -- 100,969,406(+) GAGAG(C/T)GGCGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SEMA4G Gene

Variant ID Type Subtype PubMed ID
nsv831965 CNV Loss 17160897
nsv467443 CNV Loss 19166990
nsv517698 CNV Loss 19592680
nsv895961 CNV Loss 21882294

Variation tolerance for SEMA4G Gene

Residual Variation Intolerance Score: 61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEMA4G Gene

HapMap Linkage Disequilibrium report
SEMA4G
Human Gene Mutation Database (HGMD)
SEMA4G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEMA4G Gene

Disorders for SEMA4G Gene

Relevant External Links for SEMA4G

Genetic Association Database (GAD)
SEMA4G
Human Genome Epidemiology (HuGE) Navigator
SEMA4G
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEMA4G

No disorders were found for SEMA4G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEMA4G Gene

Publications for SEMA4G Gene

  1. Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. (PMID: 19047128) Horikawa Y. … Wu X. (Clin. Cancer Res. 2008) 3 48 67
  2. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Development and application of a DNA microarray-based yeast two-hybrid system. (PMID: 23275563) Suter B. … Wanker E.E. (Nucleic Acids Res. 2013) 3
  5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3

Products for SEMA4G Gene

Sources for SEMA4G Gene

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