Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SEMA4G Gene

protein-coding   GIFtS: 58
GCID: GC10P102729

Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain...

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And
Short Cytoplasmic Domain, (Semaphorin) 4G1 2
semaphorin-4G2
KIAA16193

External Ids:    HGNC: 107351   Entrez Gene: 577152   Ensembl: ENSG000000955397   UniProtKB: Q9NTN93   

Export aliases for SEMA4G gene to outside databases

Previous GC identifers: GC10P101625 GC10P101966 GC10P102860 GC10P102396 GC10P102719 GC10P096361


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SEMA4G Gene:
Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin
(Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular
portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates
contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon
guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Feb 2011)

GeneCards Summary for SEMA4G Gene:
SEMA4G (sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G) is a protein-coding gene. Diseases associated with SEMA4G include renal cell carcinoma, and alzheimer's disease. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA3C.

UniProtKB/Swiss-Prot: SEM4G_HUMAN, Q9NTN9
Function: Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity)

Gene Wiki entry for SEMA4G Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEMA4G gene promoter:
         RFX1   p53   FOXO3   Lmo2   FOXD3   CUTL1   E47   FOXO3b   HNF-4alpha1   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEMA4G promoter sequence
   Search Chromatin IP Primers for SEMA4G

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEMA4G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.31   Ensembl cytogenetic band:  10q24.31   HGNC cytogenetic band: 10q24.31

SEMA4G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA4G gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P102729:  view genomic region     (about GC identifiers)

Start:
102,729,275 bp from pter      End:
102,745,628 bp from pter
Size:
16,354 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SEM4G_HUMAN, Q9NTN9 (See protein sequence)
Recommended Name: Semaphorin-4G precursor  
Size: 838 amino acids; 91497 Da
Subunit: Interacts with PLXNB2 (By similarity)
Sequence caution: Sequence=BAB13445.1; Type=Erroneous initiation;
Secondary accessions: A1A5C6 A6NJY8 Q58EY1 Q9HCF3
Alternative splicing: 3 isoforms:  Q9NTN9-1   Q9NTN9-2   Q9NTN9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEMA4G: NX_Q9NTN9

Explore proteomics data for SEMA4G at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn55, Asn111, Asn126, Asn388, Asn542, Asn598
  • Modification sites at PhosphoSitePlus

  • See SEMA4G Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_060363.2  NP_001190173.1  

    ENSEMBL proteins: 
     ENSP00000428896   ENSP00000430881   ENSP00000430103   ENSP00000359270   ENSP00000430175  
     ENSP00000210633   ENSP00000429888  

    SEMA4G Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for SEMA4G (Semaphorin 4G)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SEMA4G
    GenScript Custom Purified and Recombinant Proteins Services for SEMA4G
    Novus Biologicals SEMA4G Proteins
    Novus Biologicals SEMA4G Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEMA4G

    SEMA4G Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for SEMA4G (Semaphorin 4G)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SEMA4G
    Novus Biologicals SEMA4G Antibodies
    Abcam antibodies for SEMA4G
    Cloud-Clone Corp. Antibodies for SEMA4G
    Search ThermoFisher Antibodies for SEMA4G
    LSBio Antibodies in human, mouse, rat for SEMA4G

    SEMA4G Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SEMA4G
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SEMA4G
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SEMA4G
    Cloud-Clone Corp. CLIAs for SEMA4G


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    SEMA: Semaphorins

    Selected InterPro protein domains (see all 8):
     IPR002165 Plexin_repeat
     IPR013783 Ig-like_fold
     IPR027231 Semaphorin
     IPR001627 Semap_dom
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9NTN9

    ProtoNet protein and cluster: Q9NTN9

    2 Blocks protein domains:
    IPB001627 Semaphorin/CD100 antigen
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: SEM4G_HUMAN, Q9NTN9
    Similarity: Belongs to the semaphorin family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 PSI domain
    Similarity: Contains 1 Sema domain


    SEMA4G for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEM4G_HUMAN, Q9NTN9
    Function: Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----
         
    SEMA4G for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sema4g):
     cellular  nervous system  normal 

    SEMA4G for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEMA4G
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SEMA4G

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEMA4G
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEMA4G

    miRNA
    Products:
        
    miRTarBase miRNAs that target SEMA4G:
    hsa-mir-18a-3p (MIRT040791)

    Block miRNA regulation of human, mouse, rat SEMA4G using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEMA4G (see all 59):
    hsa-let-7d hsa-miR-1197 hsa-miR-1224-3p hsa-miR-106a hsa-miR-765 hsa-miR-938 hsa-miR-219-5p hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidSEMA4G 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SEMA4G
    Predesigned siRNA for gene silencing in human, mouse, rat SEMA4G

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SEMA4G

    Clone
    Products:
         
    OriGene clones in human, mouse for SEMA4G (see all 8)
    OriGene ORF clones in mouse, rat for SEMA4G
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SEMA4G (NM_017893)
    Sino Biological Human cDNA Clone for SEMA4G
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA4G
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA4G

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SEMA4G
    Browse ESI BIO Cell Lines and PureStem Progenitors for SEMA4G 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA4G


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SEM4G_HUMAN, Q9NTN9: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    extracellular1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    SEMA4G for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SEMA4G About   (see all 13)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SEMA4G (see all 54)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer



    1 Kegg Pathway  (Kegg details for SEMA4G):
        Axon guidance


    SEMA4G for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEMA4G
    Interactions:

        Search GeneGlobe Interaction Network for SEMA4G

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for SEMA4G (Q9NTN92, 3 ENSP000002106334) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIP13Q156452, 3, ENSP000001663454MINT-68011 I2D: score=4 STRING: ENSP00000166345
    DLG4P783523I2D: score=2 
    PLXNB1ENSP000002964404STRING: ENSP00000296440
    PLXNB2ENSP000003522884STRING: ENSP00000352288
    PLXNB3ENSP000003553784STRING: ENSP00000355378
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development ----
    GO:0007399nervous system development IEA--
    GO:0030154cell differentiation IEA--

    SEMA4G for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEMA4G (SEM4G)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SEMA4G gene (2 alternative transcripts): 
    NM_017893.3  NM_001203244.1  

    Unigene Cluster for SEMA4G:

    Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
    Hs.591923  [show with all ESTs]
    Unigene Representative Sequence: BC051030
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000519649 ENST00000521006(uc001krv.3 uc010qpt.1 uc001krx.3 uc001krw.2)
    ENST00000518124 ENST00000518244 ENST00000370250 ENST00000517724 ENST00000210633
    ENST00000519756 ENST00000518948 ENST00000476171 ENST00000484128

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SEMA4G using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEMA4G (see all 59):
    hsa-let-7d hsa-miR-1197 hsa-miR-1224-3p hsa-miR-106a hsa-miR-765 hsa-miR-938 hsa-miR-219-5p hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidSEMA4G 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SEMA4G
    Predesigned siRNA for gene silencing in human, mouse, rat SEMA4G
    Clone
    Products:
         
    OriGene clones in human, mouse for SEMA4G (see all 8)
    OriGene ORF clones in mouse, rat for SEMA4G
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SEMA4G (NM_017893)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA4G
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA4G
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SEMA4G
    OriGene qSTAR qPCR primer pairs in human, mouse for SEMA4G
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEMA4G
      QuantiTect SYBR Green Assays in human, mouse, rat SEMA4G
      QuantiFast Probe-based Assays in human, mouse, rat SEMA4G

    Additional mRNA sequence: 

    AB046839.1 AK000597.1 AK297431.1 BC020960.1 BC051030.1 BC053507.1 BC068039.1 BC110382.1 
    BC128579.1 

    10 DOTS entries:

    DT.453396  DT.95098189  DT.121293586  DT.121293570  DT.91745137  DT.91745138  DT.95268102  DT.430205 
    DT.75126161  DT.97846895 

    Selected AceView cDNA sequences (see all 81):

    BC053507 NM_017893 BQ084390 BC068039 AI016001 AI078359 BC051030 BM672529 
    BM769582 AI651586 AB046839 BC020960 BQ645660 AI758186 BM769795 Z42132 
    BI519944 BG393055 AI686177 AA706949 BF802506 BP872160 BX090089 BQ646403 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SEMA4G    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:              -     -     -                                       
    SP2:              -                                                   
    SP3:                                                                  
    SP4:                                                                  


    ECgene alternative splicing isoforms for SEMA4G

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SEMA4G expression in normal human tissues (normalized intensities)      SEMA4G embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACAGAGTG
    SEMA4G Expression
    About this image


    SEMA4G expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Liver (Hepatobiliary System)
             Liver Lobule
    SEMA4G Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEMA4G Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591923
        Custom PCR Arrays for SEMA4G
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SEMA4G
    OriGene qSTAR qPCR primer pairs in human, mouse for SEMA4G
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEMA4G
    QuantiTect SYBR Green Assays in human, mouse, rat SEMA4G
    QuantiFast Probe-based Assays in human, mouse, rat SEMA4G
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA4G

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for SEMA4G gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sema4g1 , 5 sema domain, immunoglobulin domain (Ig), transmembrane more1, 5 88.56(n)1
    90.55(a)1
      19 (38.16 cM)5
    264561  NM_011976.11  NP_036106.11 
     449891015 
    chicken
    (Gallus gallus)
    Aves SEMA4G6
    sema domain, immunoglobulin domain (Ig), transmemb...
    63(a)
    1 ↔ 1
    6(22627559-22632201)
    lizard
    (Anolis carolinensis)
    Reptilia SEMA4G6
    sema domain, immunoglobulin domain (Ig), transmemb...
    58(a)
    1 ↔ 1
    3(39307632-39473738)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sema4g1 sema domain, immunoglobulin domain (Ig), transmembrane more 58.07(n)
    56.8(a)
      100038182  XM_002938721.2  XP_002938767.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sema4ga1 sema domain, immunoglobulin domain (Ig), transmembrane more 56.98(n)
    53.08(a)
      563785  XM_001921388.3  XP_001921423.3 


    ENSEMBL Gene Tree for SEMA4G (if available)
    TreeFam Gene Tree for SEMA4G (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SEMA4G gene
    SEMA3C2  SEMA4F2  SEMA3E2  SEMA4B2  SEMA4C2  SEMA3F2  SEMA4A2  SEMA4D2  
    SEMA3A2  SEMA3G2  SEMA3D2  
    15 SIMAP similar genes for SEMA4G using alignment to 5 protein entries:     SEM4G_HUMAN (see all proteins):
    SEMA4C    SEMA4D    SEMA3E    DKFZp686A04130    SEMA4D variant protein    SEMA4B
    SEMA3A    SEMA3D    SEMA4A    DKFZp686D04248    SEMA3C    SEMA4F
    SEMA3F    SEMA3B    SEMA5A

    SEMA4G for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SEMA4G (see all 80)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1418649961,2
    C--102730287(+) GTCAGA/GAGCCT 2 -- us2k10--------
    rs720975491,2
    C--102730303(+) TCACC-/CAACACA 2 -- us2k10--------
    rs1167237321,2
    F--102730311(+) ACACAC/TACACA 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs353241661,2
    C--102730322(+) ACACA-/C/CA  
            
    ACCCC
    2 -- us2k11NA 2
    rs1910117781,2
    --102730329(+) CCCCCA/TCACCA 2 -- us2k10--------
    rs1178361171,2
    F--102730586(+) ATGGGT/CTTGTG 2 -- us2k11Minor allele frequency- C:0.01EA 120
    rs1388935621,2
    --102730627(+) TAGGAC/TCCTCC 2 -- us2k10--------
    rs1429149901,2
    --102730629(+) GGACCC/GTCCTG 2 -- us2k10--------
    rs1146236451,2
    F--102730714(+) ACCTGC/ATGAAT 2 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1147860021,2
    F--102730741(+) TCAACG/ATCACA 2 -- us2k11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for SEMA4G (102729275 - 102745628 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SEMA4G:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv517698CNV Loss19592680
    nsv467443CNV Loss19166990
    nsv895961CNV Loss21882294
    nsv831965CNV Loss17160897

    Human Gene Mutation Database (HGMD): SEMA4G
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEMA4G
    DNA2.0 Custom Variant and Variant Library Synthesis for SEMA4G

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    5 diseases for SEMA4G:    About MalaCards
    renal cell carcinoma    alzheimer's disease    adenocarcinoma    pancreatitis
    breast cancer


    SEMA4G for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): SEMA4G
    Human Genome Epidemiology (HuGE) Navigator: SEMA4G (2 documents)

    Export disorders for SEMA4G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SEMA4G gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with SEMA4G)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. (PubMed id 19047128)1, 4 Horikawa Y....Wu X. (Clin. Cancer Res. 2008)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    5. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    6. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (Nucleic Acids Res. 2013)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    9. Semaphorin 4B interacts with the post-synaptic density protein PSD-95/SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif. (PubMed id 15978582)1 Burkhardt C....PA1schel A.W. (FEBS Lett. 2005)
    10. Semaphorin junction: making tracks toward neural connectivity. (PubMed id 12593985)1 Pasterkamp R.J. and Kolodkin A.L. (Curr. Opin. Neurobiol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 57715 HGNC: 10735 AceView: SEMA4G Ensembl:ENSG00000095539 euGenes: HUgn57715
    ECgene: SEMA4G Kegg: 57715 H-InvDB: SEMA4G

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1619

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SEMA4G Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SEMA4G gene:
    Search GeneIP for patents involving SEMA4G

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for SEMA4G (Semaphorin 4G)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for SEMA4G (Semaphorin 4G)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SEMA4G  
     OriGene qPCR primer pairs and template standards for SEMA4G   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SEMA4G  
     OriGene qSTAR qPCR primer pairs in human, mouse for SEMA4G   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SEMA4G   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SEMA4G   OriGene Custom Protein Services for SEMA4G  

     
     
     Block miRNA regulation of human, mouse, rat SEMA4G using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SEMA4G
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEMA4G Predesigned siRNA for gene silencing in human, mouse, rat SEMA4G
     QuantiFast Probe-based Assays in human, mouse, rat SEMA4G QuantiTect SYBR Green Assays in human, mouse, rat SEMA4G
     Custom PCR Arrays for SEMA4G Search Chromatin IP Primers for SEMA4G
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEMA4G  Search GeneGlobe Interaction Network for SEMA4G
     Regulatory tfbs in SEMA4G promoter
     GenScript Custom Purified and Recombinant Proteins Services for SEMA4G GenScript cDNA clones with any tag delivered in your preferred vector for SEMA4G
     GenScript Custom Assay Services for SEMA4G GenScript Custom overexpressing Cell Line Services for SEMA4G
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SEMA4G (SEM4G)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for SEMA4G
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SEMA4G antibodies
     SEMA4G proteins
     SEMA4G lysates
     Antibodies for SEMA4G
     See all of Abcam's Antibodies, Kits and Proteins for SEMA4G
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SEMA4G
     Antibodies for SEMA4G
     ELISAs for SEMA4G
     CLIAs for SEMA4G



     Browse ESI BIO Cell Lines and PureStem Progenitors for SEMA4G
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA4G
     SwitchGear 3'UTR luciferase reporter plasmids for SEMA4G
     SwitchGear Promoter luciferase reporter plasmids for SEMA4G
     Search ThermoFisher Antibodies for SEMA4G
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA4G
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEMA4G
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SEMA4G
     LSBio Antibodies in human, mouse, rat for SEMA4G
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SEMA4G gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4