Aliases for SEMA4G Gene
External Ids for SEMA4G Gene
Previous GeneCards Identifiers for SEMA4G Gene
Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
GeneCards Summary for SEMA4G Gene
SEMA4G (Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4G) is a Protein Coding gene. Among its related pathways are NF-KappaB Family Pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA3F.
UniProtKB/Swiss-Prot for SEMA4G Gene
Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity).