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SEMA4F Gene

protein-coding   GIFtS: 57
GCID: GC02P074793

Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain...


(Previous symbol: SEMAM)
  See SEMA4F-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And
Short Cytoplasmic Domain, (Semaphorin) 4F1 2
     Semaphorin M2
SEMAM1 2 3     semaphorin-4F2
SEMAW2 3 5     semaphorin-M2
M-Sema M1     semaphorin-W2
M-SEMA2     Semaphorin-M3
PRO23532     Semaphorin-W3
S4F2     Sema M3
m-Sema-M2     Sema W3

External Ids:    HGNC: 107341   Entrez Gene: 105052   Ensembl: ENSG000001356227   OMIM: 6037065   UniProtKB: O957543   

Export aliases for SEMA4F gene to outside databases

Previous GC identifers: GC01P099863 GC02P075094 GC02P074839 GC02P074855 GC02P074618


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SEMA4F Gene:
This gene encodes a transmembrane class IV semaphorin family protein, which plays a role in neural development.
This gene may be involved in neurogenesis in prostate cancer, the development of neurofibromas, and breast cancer
tumorigenesis. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Nov 2012)

GeneCards Summary for SEMA4F Gene:
SEMA4F (sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F) is a protein-coding gene. Diseases associated with SEMA4F include prostate cancer, and breast cancer. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA3C.

UniProtKB/Swiss-Prot: SEM4F_HUMAN, O95754
Function: Has growth cone collapse activity against retinal ganglion-cell axons (By similarity)

Gene Wiki entry for SEMA4F Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEMA4F gene promoter:
         COUP-TF1   AML1a   Pax-5   Tal-1   COUP   HNF-4alpha2   HNF-4alpha1   COUP-TF   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEMA4F promoter sequence
   Search Chromatin IP Primers for SEMA4F

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEMA4F


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.1   Ensembl cytogenetic band:  2p13.1   HGNC cytogenetic band: 2p13.1

SEMA4F Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA4F gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P074793:  view genomic region     (about GC identifiers)

Start:
74,881,355 bp from pter      End:
74,909,186 bp from pter
Size:
27,832 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SEM4F_HUMAN, O95754 (See protein sequence)
Recommended Name: Semaphorin-4F precursor  
Size: 770 amino acids; 83511 Da
Secondary accessions: Q542Y7 Q9NS35
Alternative splicing: 2 isoforms:  O95754-1   O95754-2   

Explore the universe of human proteins at neXtProt for SEMA4F: NX_O95754

Explore proteomics data for SEMA4F at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn64, Asn133, Asn509
  • Modification sites at PhosphoSitePlus

  • See SEMA4F Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001258590.1  NP_001258591.1  NP_004254.2  

    ENSEMBL proteins: 
     ENSP00000350547   ENSP00000416490   ENSP00000413882   ENSP00000342675   ENSP00000407698  
     ENSP00000396703   ENSP00000409141   ENSP00000413916  

    SEMA4F Human Recombinant Protein Products:

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    OriGene Purified Protein for SEMA4F
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    Novus Biologicals SEMA4F Protein
    Novus Biologicals SEMA4F Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEMA4F

     
    Search eBioscience for Proteins for SEMA4F 

     
    antibodies-online proteins for SEMA4F (3 products) 

     
    Search antibodies-online for peptides for SEMA4F

    SEMA4F Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for SEMA4F
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    antibodies-online antibodies for SEMA4F (28 products) 

    SEMA4F Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for SEMA4F
    Cloud-Clone Corp. CLIAs for SEMA4F
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    antibodies-online kits for SEMA4F (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SEMA: Semaphorins

    Selected InterPro protein domains (see all 6):
     IPR002165 Plexin_repeat
     IPR015512 Seamphorin_4F
     IPR027231 Semaphorin
     IPR001627 Semap_dom
     IPR016201 Plexin-like_fold

    Graphical View of Domain Structure for InterPro Entry O95754

    ProtoNet protein and cluster: O95754

    1 Blocks protein domain: IPB001627 Semaphorin/CD100 antigen

    UniProtKB/Swiss-Prot: SEM4F_HUMAN, O95754
    Similarity: Belongs to the semaphorin family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 PSI domain
    Similarity: Contains 1 Sema domain


    Find genes that share domains with SEMA4F           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEM4F_HUMAN, O95754
    Function: Has growth cone collapse activity against retinal ganglion-cell axons (By similarity)

         Genatlas biochemistry entry for SEMA4F:
    semaphorin 4F,expressed at low levels in the developing embryo and at high levels in the adult central nervous
    system and lung,repellent of the nerve growth cone guidance

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SEMA4F           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SEMA4F:
     Increased S DNA content  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SEMA4F

    miRNA
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    Block miRNA regulation of human, mouse, rat SEMA4F using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEMA4F (see all 47):
    hsa-let-7d hsa-miR-513a-5p hsa-miR-1260b hsa-miR-500a hsa-miR-449a hsa-let-7g hsa-miR-3142 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidSEMA4F 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SEMA4F
    Predesigned siRNA for gene silencing in human, mouse, rat SEMA4F

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SEMA4F

    Clone
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    OriGene clones in human, mouse for SEMA4F (see all 7)
    OriGene ORF clones in mouse, rat for SEMA4F
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEMA4F (NM_004263)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA4F
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA4F

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SEMA4F 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA4F


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SEM4F_HUMAN, O95754: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    plasma membrane4
    cytosol1
    extracellular1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005886plasma membrane TAS10051670
    GO:0005887integral component of plasma membrane TAS10051670
    GO:0016020membrane TAS10051670
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with SEMA4F           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SEMA4F About    
    See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Axon guidance


    Find genes that share SuperPaths with SEMA4F           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for SEMA4F):
        Axon guidance

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEMA4F
    Interactions:

        GeneGlobe Interaction Network for SEMA4F

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for SEMA4F (O957543 ENSP000003505474) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NRP2O604623, ENSP000003535824I2D: score=2 STRING: ENSP00000353582
    DLG4P783523I2D: score=1 
    PLXNB1ENSP000002964404STRING: ENSP00000296440
    PLXNB2ENSP000003522884STRING: ENSP00000352288
    PLXNB3ENSP000003553784STRING: ENSP00000355378
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007267cell-cell signaling TAS10051670
    GO:0007275multicellular organismal development ----
    GO:0007399nervous system development TAS10051670
    GO:0007411axon guidance TAS10051670
    GO:0030517negative regulation of axon extension IEA--

    Find genes that share ontologies with SEMA4F           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEMA4F (SEM4F)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SEMA4F gene (3 alternative transcripts): 
    NM_001271661.1  NM_001271662.1  NM_004263.4  

    Unigene Cluster for SEMA4F:

    Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
    Hs.25887  [show with all ESTs]
    Unigene Representative Sequence: NM_004263
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357877(uc010ysb.1 uc021vjn.1 uc010ffq.1 uc002sna.1 uc010ffr.1 uc002snb.1 uc002snc.1)
    ENST00000420077 ENST00000458114 ENST00000339773 ENST00000434486 ENST00000416236
    ENST00000453930 ENST00000446927 ENST00000473350
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SEMA4F using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEMA4F (see all 47):
    hsa-let-7d hsa-miR-513a-5p hsa-miR-1260b hsa-miR-500a hsa-miR-449a hsa-let-7g hsa-miR-3142 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidSEMA4F 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat SEMA4F
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEMA4F (NM_004263)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA4F
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SEMA4F
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEMA4F
      QuantiTect SYBR Green Assays in human, mouse, rat SEMA4F
      QuantiFast Probe-based Assays in human, mouse, rat SEMA4F

    Additional mRNA sequence: 

    AB021292.1 AB022317.1 AF053369.1 AK075384.1 AK095587.1 AK291023.1 AK304358.1 AK308166.1 
    AK312728.1 AL136552.1 BC018361.1 BC038411.1 NR_073398.1 NR_073399.1 

    9 DOTS entries:

    DT.107478  DT.100024488  DT.102822463  DT.92423256  DT.99993166  DT.100751727  DT.95153855  DT.102822462 
    DT.95161449 

    Selected AceView cDNA sequences (see all 86):

    AB022317 BM704458 BE464822 BC018361 AW953466 BE504297 BC038411 AI289278 
    CD673852 CA423139 AL136552 BM987806 AK075384 AW957134 NM_004263 AW206442 
    BM833881 BG774505 BU618204 BU736624 AI133725 Z41043 BE734978 BM462308 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SEMA4F expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTCTAGGCT
    SEMA4F Expression
    About this image


    SEMA4F expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Conventional Dendritic Cells I Spleen
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
     
     Liver (Hepatobiliary System)
             Hematopoietic Stem Cells Liver Bud
     
     Bone (Muscoskeletal System)
             Mandibular Condyle
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
    SEMA4F Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEMA4F Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.25887
        Custom PCR Arrays for SEMA4F
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SEMA4F
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA4F

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SEMA4F gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sema4f1 , 5 sema domain, immunoglobulin domain (Ig), TM domain, more1, 5 87.79(n)1
    91.3(a)1
      6 (35.94 cM)5
    203551  NM_011350.31  NP_035480.31 
     829118855 
    lizard
    (Anolis carolinensis)
    Reptilia SEMA4F6
    sema domain, immunoglobulin domain (Ig), transmemb...
    50(a)
    1 ↔ 1
    GL344170.1(32636-47086)
    zebrafish
    (Danio rerio)
    Actinopterygii sema4f1 sema domain, immunoglobulin domain (Ig), transmembrane more 48.63(n)
    39.19(a)
      556003  XM_678693.5  XP_683785.5 


    ENSEMBL Gene Tree for SEMA4F (if available)
    TreeFam Gene Tree for SEMA4F (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SEMA4F gene
    SEMA3C2  SEMA3E2  SEMA4B2  SEMA4C2  SEMA3F2  SEMA4A2  SEMA4D2  SEMA4G2  
    SEMA3A2  SEMA3G2  SEMA3D2  
    15 SIMAP similar genes for SEMA4F using alignment to 7 protein entries:     SEM4F_HUMAN (see all proteins):
    SEMA4D    DKFZp686A04130    SEMA3E    SEMA5A    SEMA4D variant protein    SEMA6A
    SEMA4C    DKFZp686D04248    SEMA3A    SEMA4A    SEMA6D    SEMA3B
    SEMA4G    SEMA4B    SEMA3D

    Find genes that share paralogs with SEMA4F           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SEMA4F (see all 733)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1463648981,2
    --74879530(+) CCTGAA/GCTATG 5 -- us2k10--------
    rs1905623151,2
    --74879557(+) AAGGAC/TGGATT 5 -- us2k10--------
    rs1391676201,2
    --74879695(+) GTCCCA/CTTCCA 5 -- us2k10--------
    rs1440501581,2
    --74879716(+) GGGCTA/GCCCTG 5 -- us2k10--------
    rs1818891331,2
    --74879879(+) ATTCAC/TGTGGA 5 -- us2k10--------
    rs1383026751,2
    C--74879907(+) GCCAA-/CCCCCCCCC
    /CCCCCCCCCC
    CAGCC
    8 -- us2k1 cds10--------
    rs1862206391,2
    --74879997(+) TGCCCC/TGTTTG 5 -- us2k10--------
    rs1889779581,2
    --74880071(+) TTTCTA/GACGCA 5 -- us2k10--------
    rs1815181201,2
    --74880141(+) AGCAAA/TTCGAA 5 -- us2k10--------
    rs1147954061,2
    F--74880217(+) TTGTTT/CTGCAG 5 -- us2k11Minor allele frequency- C:0.01NA 120

    HapMap Linkage Disequilibrium report for SEMA4F (74881355 - 74909186 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SEMA4F:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829464CNV Loss20364138
    nsv819293CNV Loss19587683
    dgv4167n71CNV Gain21882294
    nsv874292CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603706    OMIM disorders: --

    2 diseases for SEMA4F:    
    About MalaCards
    prostate cancer    breast cancer


    Find genes that share disorders with SEMA4F           About GenesLikeMe

    Genetic Association Database (GAD): SEMA4F

    Export disorders for SEMA4F gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SEMA4F gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with SEMA4F)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression, and genetic mapping of Sema W, a member of the semaphorin family. (PubMed id 10051670)1, 2, 3 Encinas J.A....Kimura T. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    2. Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1. (PubMed id 11901358)1, 4, 9 Francks C....Monaco A.P. (Psychiatr. Genet. 2002)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    7. NF1 loss disrupts Schwann cell-axonal interactions: a novel role for semaphorin 4F. (PubMed id 19056885)1, 9 Parrinello S....Lloyd A.C. (amp 2008)
    8. Comprehensive gene and microRNA expression profiling reveals the crucial role of hsa-let-7i and its target genes in colorectal cancer metastasis. (PubMed id 21625861)1 Zhang P....Qin H. (Mol. Biol. Rep. 2012)
    9. Expression of Semaphorin 4F in neurons and brain oligodendrocytes and the regulation of oligodendrocyte precursor migration in the optic nerve. (PubMed id 21945643)1 ArmendA!riz B.G....Burgaya F. (Mol. Cell. Neurosci. 2012)
    10. Genetic variants on chromosome 1q41 influence ocular axial length and high myopia. (PubMed id 22685421)1 Fan Q....Saw S.M. (PLoS Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10505 HGNC: 10734 AceView: SEMA4F Ensembl:ENSG00000135622 euGenes: HUgn10505
    ECgene: SEMA4F Kegg: 10505 H-InvDB: SEMA4F

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SEMA4F Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SEMA4F Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SEMA4F gene:
    Search GeneIP for patents involving SEMA4F

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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