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Aliases for SEMA4F Gene

Aliases for SEMA4F Gene

  • Ssemaphorin 4F 2 3
  • Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4F 2 3 5
  • Semaphorin-M 3 4
  • Semaphorin-W 3 4
  • SEMAM 3 4
  • SEMAW 3 4
  • Sema Domain Immunoglobulin Domain Transmembrane Domain (TM) And Short Cytoplasmic Domain (Semaphorin) 4F 3
  • Semaphorin M 3
  • M-Sema M 2
  • M-Sema-M 3
  • PRO2353 3
  • M-SEMA 3
  • Sema M 4
  • Sema W 4
  • S4F 3

External Ids for SEMA4F Gene

Previous HGNC Symbols for SEMA4F Gene


Previous GeneCards Identifiers for SEMA4F Gene

  • GC01P099863
  • GC02P075094
  • GC02P074839
  • GC02P074855
  • GC02P074793
  • GC02P074618

Summaries for SEMA4F Gene

Entrez Gene Summary for SEMA4F Gene

  • This gene encodes a transmembrane class IV semaphorin family protein, which plays a role in neural development. This gene may be involved in neurogenesis in prostate cancer, the development of neurofibromas, and breast cancer tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for SEMA4F Gene

SEMA4F (Ssemaphorin 4F) is a Protein Coding gene. Among its related pathways are Axon guidance. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA3F.

UniProtKB/Swiss-Prot for SEMA4F Gene

  • Has growth cone collapse activity against retinal ganglion-cell axons.

Gene Wiki entry for SEMA4F Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMA4F Gene

Genomics for SEMA4F Gene

Regulatory Elements for SEMA4F Gene

Enhancers for SEMA4F Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SEMA4F on UCSC Golden Path with GeneCards custom track

Promoters for SEMA4F Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SEMA4F on UCSC Golden Path with GeneCards custom track

Genomic Location for SEMA4F Gene

74,654,228 bp from pter
74,694,897 bp from pter
40,670 bases
Plus strand

Genomic View for SEMA4F Gene

Genes around SEMA4F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEMA4F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEMA4F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA4F Gene

Proteins for SEMA4F Gene

  • Protein details for SEMA4F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q542Y7
    • Q9NS35

    Protein attributes for SEMA4F Gene

    770 amino acids
    Molecular mass:
    83511 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SEMA4F Gene


neXtProt entry for SEMA4F Gene

Proteomics data for SEMA4F Gene at MOPED

Post-translational modifications for SEMA4F Gene

  • Glycosylation at Asn 64, Asn 133, and Asn 509
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for SEMA4F (Semaphorin 4F)

No data available for DME Specific Peptides for SEMA4F Gene

Domains & Families for SEMA4F Gene

Gene Families for SEMA4F Gene

Suggested Antigen Peptide Sequences for SEMA4F Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Belongs to the semaphorin family.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 PSI domain.
  • Contains 1 Sema domain.
  • Belongs to the semaphorin family.
genes like me logo Genes that share domains with SEMA4F: view

Function for SEMA4F Gene

Molecular function for SEMA4F Gene

GENATLAS Biochemistry:
semaphorin 4F,expressed at low levels in the developing embryo and at high levels in the adult central nervous system and lung,repellent of the nerve growth cone guidance
UniProtKB/Swiss-Prot Function:
Has growth cone collapse activity against retinal ganglion-cell axons.
genes like me logo Genes that share phenotypes with SEMA4F: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SEMA4F

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEMA4F Gene

Localization for SEMA4F Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA4F Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for SEMA4F Gene COMPARTMENTS Subcellular localization image for SEMA4F gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
extracellular 4
cytosol 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SEMA4F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0016021 integral component of membrane IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with SEMA4F: view

Pathways & Interactions for SEMA4F Gene

SuperPathways for SEMA4F Gene

Superpath Contained pathways
1 Axon guidance
genes like me logo Genes that share pathways with SEMA4F: view

Pathways by source for SEMA4F Gene

1 KEGG pathway for SEMA4F Gene

Interacting Proteins for SEMA4F Gene

Gene Ontology (GO) - Biological Process for SEMA4F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001755 neural crest cell migration IBA --
GO:0007411 axon guidance IEA,TAS 10051670
GO:0030335 positive regulation of cell migration IBA --
genes like me logo Genes that share ontologies with SEMA4F: view

No data available for SIGNOR curated interactions for SEMA4F Gene

Drugs & Compounds for SEMA4F Gene

No Compound Related Data Available

Transcripts for SEMA4F Gene

Unigene Clusters for SEMA4F Gene

Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA4F Gene

No ASD Table

Relevant External Links for SEMA4F Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEMA4F Gene

mRNA expression in normal human tissues for SEMA4F Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SEMA4F Gene

This gene is overexpressed in Plasma (58.8) and Peripheral blood mononuclear cells (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SEMA4F Gene

SOURCE GeneReport for Unigene cluster for SEMA4F Gene Hs.25887

genes like me logo Genes that share expression patterns with SEMA4F: view

Protein tissue co-expression partners for SEMA4F Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SEMA4F Gene

Orthologs for SEMA4F Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEMA4F Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SEMA4F 35
  • 89.61 (n)
  • 91.63 (a)
  • 90 (a)
(Canis familiaris)
Mammalia SEMA4F 35
  • 91.26 (n)
  • 93.12 (a)
  • 90 (a)
(Mus musculus)
Mammalia Sema4f 35
  • 87.79 (n)
  • 91.3 (a)
Sema4f 16
Sema4f 36
  • 90 (a)
(Pan troglodytes)
Mammalia SEMA4F 35
  • 99.18 (n)
  • 98.96 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Sema4f 35
  • 87.92 (n)
  • 91.43 (a)
(Monodelphis domestica)
Mammalia SEMA4F 36
  • 68 (a)
(Anolis carolinensis)
Reptilia SEMA4F 36
  • 50 (a)
(Danio rerio)
Actinopterygii sema4f 35
  • 48.63 (n)
  • 39.19 (a)
sema4f 36
  • 39 (a)
Species with no ortholog for SEMA4F:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEMA4F Gene

Gene Tree for SEMA4F (if available)
Gene Tree for SEMA4F (if available)

Paralogs for SEMA4F Gene

genes like me logo Genes that share paralogs with SEMA4F: view

Variants for SEMA4F Gene

Sequence variations from dbSNP and Humsavar for SEMA4F Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs363607 -- 74,669,798(+) TTTAC(A/T)CATAA intron-variant
rs363608 -- 74,674,475(+) AGAAC(C/G/T)TCCCA intron-variant
rs363609 -- 74,675,745(+) TTTTT(A/G)TAGAG intron-variant
rs363610 -- 74,678,612(+) CTCTG(C/G)GAGTG intron-variant
rs363611 -- 74,679,073(+) TGGAA(C/T)TTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEMA4F Gene

Variant ID Type Subtype PubMed ID
nsv874292 CNV Gain 21882294
dgv4167n71 CNV Gain 21882294
nsv829464 CNV Loss 20364138
nsv819293 CNV Loss 19587683

Variation tolerance for SEMA4F Gene

Residual Variation Intolerance Score: 16.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.89% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SEMA4F Gene

Disorders for SEMA4F Gene

Relevant External Links for SEMA4F

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SEMA4F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEMA4F Gene

Publications for SEMA4F Gene

  1. Cloning, expression, and genetic mapping of Sema W, a member of the semaphorin family. (PMID: 10051670) Encinas J.A. … Kimura T. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 67
  2. NF1 loss disrupts Schwann cell-axonal interactions: a novel role for semaphorin 4F. (PMID: 19056885) Parrinello S. … Lloyd A.C. (Genes Dev. 2008) 3 23
  3. Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1. (PMID: 11901358) Francks C. … Monaco A.P. (Psychiatr. Genet. 2002) 3 23
  4. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for SEMA4F Gene

Sources for SEMA4F Gene