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Aliases for SEMA4F Gene

Aliases for SEMA4F Gene

  • Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4F 2 3
  • SEMAW 3 4 6
  • Semaphorin-M 3 4
  • Semaphorin-W 3 4
  • SEMAM 3 4
  • Semaphorin-4F 3
  • Semaphorin M 3
  • M-Sema M 2
  • M-Sema-M 3
  • PRO2353 3
  • M-SEMA 3
  • Sema M 4
  • Sema W 4
  • S4F 3

External Ids for SEMA4F Gene

Previous HGNC Symbols for SEMA4F Gene


Previous GeneCards Identifiers for SEMA4F Gene

  • GC01P099863
  • GC02P075094
  • GC02P074839
  • GC02P074855
  • GC02P074793
  • GC02P074618

Summaries for SEMA4F Gene

Entrez Gene Summary for SEMA4F Gene

  • This gene encodes a transmembrane class IV semaphorin family protein, which plays a role in neural development. This gene may be involved in neurogenesis in prostate cancer, the development of neurofibromas, and breast cancer tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for SEMA4F Gene

SEMA4F (Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4F) is a Protein Coding gene. Diseases associated with SEMA4F include prostate cancer and breast cancer. Among its related pathways are Axon guidance. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA4G.

UniProtKB/Swiss-Prot for SEMA4F Gene

  • Has growth cone collapse activity against retinal ganglion-cell axons.

Gene Wiki entry for SEMA4F Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMA4F Gene

Genomics for SEMA4F Gene

Regulatory Elements for SEMA4F Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SEMA4F Gene

74,654,228 bp from pter
74,683,854 bp from pter
29,627 bases
Plus strand

Genomic View for SEMA4F Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEMA4F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA4F Gene

Proteins for SEMA4F Gene

  • Protein details for SEMA4F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q542Y7
    • Q9NS35

    Protein attributes for SEMA4F Gene

    770 amino acids
    Molecular mass:
    83511 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SEMA4F Gene


neXtProt entry for SEMA4F Gene

Proteomics data for SEMA4F Gene at MOPED

Post-translational modifications for SEMA4F Gene

  • Glycosylation at Asn64, Asn133, and Asn509
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SEMA4F Gene

Domains for SEMA4F Gene

Gene Families for SEMA4F Gene


Suggested Antigen Peptide Sequences for SEMA4F Gene

Graphical View of Domain Structure for InterPro Entry



  • O95754
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 PSI domain.
  • Contains 1 Sema domain.
  • Belongs to the semaphorin family.
genes like me logo Genes that share domains with SEMA4F: view

Function for SEMA4F Gene

Molecular function for SEMA4F Gene

GENATLAS Biochemistry: semaphorin 4F,expressed at low levels in the developing embryo and at high levels in the adult central nervous system and lung,repellent of the nerve growth cone guidance
UniProtKB/Swiss-Prot Function: Has growth cone collapse activity against retinal ganglion-cell axons.

Gene Ontology (GO) - Molecular Function for SEMA4F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SEMA4F: view

Phenotypes for SEMA4F Gene

GenomeRNAi human phenotypes for SEMA4F:
genes like me logo Genes that share phenotypes with SEMA4F: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEMA4F

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SEMA4F Gene

Localization for SEMA4F Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA4F Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for SEMA4F Gene COMPARTMENTS Subcellular localization image for SEMA4F gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 4
cytosol 1
extracellular 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SEMA4F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005886 plasma membrane TAS 10051670
GO:0005887 integral component of plasma membrane TAS 10051670
GO:0016020 membrane TAS 10051670
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SEMA4F: view

Pathways for SEMA4F Gene

SuperPathways for SEMA4F Gene

Superpath Contained pathways
1 Axon guidance
genes like me logo Genes that share pathways with SEMA4F: view

Pathways by source for SEMA4F Gene

1 KEGG pathway for SEMA4F Gene

Interacting Proteins for SEMA4F Gene

Gene Ontology (GO) - Biological Process for SEMA4F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling TAS 10051670
GO:0007275 multicellular organismal development --
GO:0007399 nervous system development TAS 10051670
GO:0007411 axon guidance TAS 10051670
GO:0030517 negative regulation of axon extension IEA --
genes like me logo Genes that share ontologies with SEMA4F: view

Transcripts for SEMA4F Gene

Unigene Clusters for SEMA4F Gene

Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEMA4F

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SEMA4F

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA4F Gene

No ASD Table

Relevant External Links for SEMA4F Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEMA4F Gene

mRNA expression in normal human tissues for SEMA4F Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SEMA4F Gene

SOURCE GeneReport for Unigene cluster for SEMA4F Gene Hs.25887

genes like me logo Genes that share expressions with SEMA4F: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SEMA4F Gene

Orthologs for SEMA4F Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEMA4F Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SEMA4F 35
  • 99.18 (n)
  • 98.96 (a)
  • 99 (a)
(Bos Taurus)
Mammalia SEMA4F 35
  • 89.61 (n)
  • 91.63 (a)
  • 90 (a)
(Canis familiaris)
Mammalia SEMA4F 35
  • 91.26 (n)
  • 93.12 (a)
  • 90 (a)
(Mus musculus)
Mammalia Sema4f 35
  • 87.79 (n)
  • 91.3 (a)
Sema4f 16
Sema4f 36
  • 90 (a)
(Monodelphis domestica)
Mammalia SEMA4F 36
  • 68 (a)
(Rattus norvegicus)
Mammalia Sema4f 35
  • 87.92 (n)
  • 91.43 (a)
(Anolis carolinensis)
Reptilia SEMA4F 36
  • 50 (a)
(Danio rerio)
Actinopterygii sema4f 35
  • 48.63 (n)
  • 39.19 (a)
sema4f 36
  • 39 (a)
Species with no ortholog for SEMA4F:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEMA4F Gene

Gene Tree for SEMA4F (if available)
Gene Tree for SEMA4F (if available)

Paralogs for SEMA4F Gene

genes like me logo Genes that share paralogs with SEMA4F: view

Variants for SEMA4F Gene

Sequence variations from dbSNP and Humsavar for SEMA4F Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs183273 -- 74,668,930(+) tggcc(A/C)aaaaa intron-variant
rs205648 -- 74,673,368(+) TCGCT(A/G)CCCTG intron-variant
rs205649 -- 74,670,996(+) TCTTT(A/G)TTTAT intron-variant
rs205650 -- 74,657,484(+) GTTAT(A/G)GAACA intron-variant
rs363607 -- 74,669,798(+) TTTAC(A/T)CATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEMA4F Gene

Variant ID Type Subtype PubMed ID
nsv874292 CNV Gain 21882294
dgv4167n71 CNV Gain 21882294
nsv829464 CNV Loss 20364138
nsv819293 CNV Loss 19587683

Relevant External Links for SEMA4F Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEMA4F Gene

Disorders for SEMA4F Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for SEMA4F Gene including...

Search for SEMA4F Gene in MalaCards »

Relevant External Links for SEMA4F

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with SEMA4F: view

No data available for UniProtKB/Swiss-Prot for SEMA4F Gene

Publications for SEMA4F Gene

  1. Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1. (PMID: 11901358) Francks C. … Monaco A.P. (Psychiatr. Genet. 2002) 3 23 48
  2. Cloning, expression, and genetic mapping of Sema W, a member of the semaphorin family. (PMID: 10051670) Encinas J.A. … Kimura T. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4
  3. NF1 loss disrupts Schwann cell-axonal interactions: a novel role for semaphorin 4F. (PMID: 19056885) Parrinello S. … Lloyd A.C. (Genes Dev. 2008) 3 23
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for SEMA4F Gene

  • antibodies-online proteins for SEMA4F
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  • antibodies-online kits for SEMA4F

Sources for SEMA4F Gene

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