Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SEMA4F Gene

Aliases for SEMA4F Gene

  • Ssemaphorin 4F 2 3 5
  • Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4F 2 3
  • Semaphorin-W 3 4
  • SEMAM 3 4
  • SEMAW 3 4
  • Sema Domain Immunoglobulin Domain Transmembrane Domain (TM) And Short Cytoplasmic Domain (Semaphorin) 4F 3
  • Semaphorin-4F 3
  • Semaphorin M 3
  • Semaphorin-M 4
  • M-Sema M 2
  • M-Sema-M 3
  • PRO2353 3
  • M-SEMA 3
  • Sema M 4
  • Sema W 4
  • S4F 3

External Ids for SEMA4F Gene

Previous HGNC Symbols for SEMA4F Gene


Previous GeneCards Identifiers for SEMA4F Gene

  • GC01P099863
  • GC02P075094
  • GC02P074839
  • GC02P074855
  • GC02P074793
  • GC02P074618

Summaries for SEMA4F Gene

Entrez Gene Summary for SEMA4F Gene

  • This gene encodes a transmembrane class IV semaphorin family protein, which plays a role in neural development. This gene may be involved in neurogenesis in prostate cancer, the development of neurofibromas, and breast cancer tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for SEMA4F Gene

SEMA4F (Ssemaphorin 4F) is a Protein Coding gene. Among its related pathways are Axon guidance. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA4B.

UniProtKB/Swiss-Prot for SEMA4F Gene

  • Has growth cone collapse activity against retinal ganglion-cell axons.

Gene Wiki entry for SEMA4F Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMA4F Gene

Genomics for SEMA4F Gene

Regulatory Elements for SEMA4F Gene

Enhancers for SEMA4F Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G074566 1.6 FANTOM5 Ensembl ENCODE dbSUPER 22.2 -86.4 -86401 3.1 ZFP64 EBF1 ZNF697 CBX5 SCRT2 FOS RELB IKZF2 NFE2L2 EZH2 SEMA4F LBX2 BOLA3-AS1 DUSP11 WBP1 HTRA2 AUP1 TLX2 PCGF1 ENSG00000270571
GH02G074739 1.5 FANTOM5 Ensembl ENCODE 16.6 +86.8 86789 3.6 PKNOX1 ATF1 ARNT MLX ARID4B SIN3A DMAP1 BRCA1 ZNF48 GTF3C2 MOGS SEMA4F DUSP11 PCGF1 WBP1 ENSG00000273245 DGUOK-AS1 CCDC142 M1AP TLX2
GH02G073969 1.7 Ensembl ENCODE dbSUPER 12.6 -683.2 -683208 2.8 CREB3L1 AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC DUSP11 PCGF1 DGUOK-AS1 ENSG00000273245 SEMA4F DCTN1 CCDC142 MOGS WBP1 LOC107985899
GH02G074842 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +193.4 193376 10.0 FOXA2 ZFP64 ARID4B SIN3A GATA2 FOS DEK ZHX2 JUNB PPARG HK2 SEMA4F M1AP ENSG00000236209 LINC01293 LBX2 GC02M074813 GC02M074860
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SEMA4F on UCSC Golden Path with GeneCards custom track

Promoters for SEMA4F Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000119201 -27 1200 PKNOX1 ATF1 AGO1 GLI4 ZNF2 SLC30A9 ELK1 KLF7 FOS KLF13

Genomic Location for SEMA4F Gene

74,654,228 bp from pter
74,694,897 bp from pter
40,670 bases
Plus strand

Genomic View for SEMA4F Gene

Genes around SEMA4F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEMA4F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEMA4F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA4F Gene

Proteins for SEMA4F Gene

  • Protein details for SEMA4F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q542Y7
    • Q9NS35

    Protein attributes for SEMA4F Gene

    770 amino acids
    Molecular mass:
    83511 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SEMA4F Gene


neXtProt entry for SEMA4F Gene

Post-translational modifications for SEMA4F Gene

  • Glycosylation at isoforms=264, Asn133, and Asn509
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SEMA4F Gene

Domains & Families for SEMA4F Gene

Gene Families for SEMA4F Gene

Suggested Antigen Peptide Sequences for SEMA4F Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the semaphorin family.
  • Belongs to the semaphorin family.
genes like me logo Genes that share domains with SEMA4F: view

Function for SEMA4F Gene

Molecular function for SEMA4F Gene

GENATLAS Biochemistry:
semaphorin 4F,expressed at low levels in the developing embryo and at high levels in the adult central nervous system and lung,repellent of the nerve growth cone guidance
UniProtKB/Swiss-Prot Function:
Has growth cone collapse activity against retinal ganglion-cell axons.
genes like me logo Genes that share phenotypes with SEMA4F: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SEMA4F

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEMA4F Gene

Localization for SEMA4F Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA4F Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEMA4F gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
extracellular 1
mitochondrion 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SEMA4F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005886 plasma membrane TAS 10051670
GO:0005887 integral component of plasma membrane TAS 10051670
GO:0016020 membrane IEA,TAS 10051670
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SEMA4F: view

Pathways & Interactions for SEMA4F Gene

SuperPathways for SEMA4F Gene

SuperPathway Contained pathways
1 Axon guidance
genes like me logo Genes that share pathways with SEMA4F: view

Pathways by source for SEMA4F Gene

1 KEGG pathway for SEMA4F Gene

Gene Ontology (GO) - Biological Process for SEMA4F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling TAS 10051670
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development TAS 10051670
GO:0007411 axon guidance TAS,IEA 10051670
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SEMA4F: view

No data available for SIGNOR curated interactions for SEMA4F Gene

Drugs & Compounds for SEMA4F Gene

No Compound Related Data Available

Transcripts for SEMA4F Gene

Unigene Clusters for SEMA4F Gene

Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA4F Gene

No ASD Table

Relevant External Links for SEMA4F Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEMA4F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEMA4F Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SEMA4F Gene

This gene is overexpressed in Plasma (58.8) and Peripheral blood mononuclear cells (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SEMA4F Gene

Protein tissue co-expression partners for SEMA4F Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SEMA4F Gene:


SOURCE GeneReport for Unigene cluster for SEMA4F Gene:


Evidence on tissue expression from TISSUES for SEMA4F Gene

  • Nervous system(4.9)
  • Pancreas(3)
genes like me logo Genes that share expression patterns with SEMA4F: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEMA4F Gene

Orthologs for SEMA4F Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEMA4F Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SEMA4F 34 35
  • 99.18 (n)
(Canis familiaris)
Mammalia SEMA4F 34 35
  • 91.26 (n)
(Bos Taurus)
Mammalia SEMA4F 34 35
  • 89.61 (n)
(Rattus norvegicus)
Mammalia Sema4f 34
  • 87.92 (n)
(Mus musculus)
Mammalia Sema4f 34 16 35
  • 87.79 (n)
(Monodelphis domestica)
Mammalia SEMA4F 35
  • 68 (a)
(Anolis carolinensis)
Reptilia SEMA4F 35
  • 50 (a)
(Danio rerio)
Actinopterygii sema4f 34 35
  • 48.63 (n)
Species where no ortholog for SEMA4F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEMA4F Gene

Gene Tree for SEMA4F (if available)
Gene Tree for SEMA4F (if available)

Paralogs for SEMA4F Gene

Variants for SEMA4F Gene

Sequence variations from dbSNP and Humsavar for SEMA4F Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000050839 -- 74,667,040(+) TTTAT(C/T)ATAAC intron-variant
rs1000086577 -- 74,654,579(+) CACCC(A/G)CCTGC intron-variant
rs1000113419 -- 74,674,034(+) TGTCT(A/G)CAGTG intron-variant
rs1000119499 -- 74,669,221(+) GAGAA(A/T)TGCTT intron-variant
rs1000255931 -- 74,668,892(+) CCCAA(A/G)GTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEMA4F Gene

Variant ID Type Subtype PubMed ID
esv3591284 CNV gain 21293372
esv3591285 CNV gain 21293372
nsv1001495 CNV gain 25217958
nsv1003960 CNV gain 25217958
nsv582216 CNV gain 21841781
nsv819293 CNV loss 19587683
nsv829464 CNV loss 20364138

Variation tolerance for SEMA4F Gene

Residual Variation Intolerance Score: 16.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEMA4F Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEMA4F Gene

Disorders for SEMA4F Gene

Relevant External Links for SEMA4F

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SEMA4F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEMA4F Gene

Publications for SEMA4F Gene

  1. Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1. (PMID: 11901358) Francks C. … Monaco A.P. (Psychiatr. Genet. 2002) 3 22 46 64
  2. Cloning, expression, and genetic mapping of Sema W, a member of the semaphorin family. (PMID: 10051670) Encinas J.A. … Kimura T. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 64
  3. NF1 loss disrupts Schwann cell-axonal interactions: a novel role for semaphorin 4F. (PMID: 19056885) Parrinello S. … Lloyd A.C. (Genes Dev. 2008) 3 22 64
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64

Products for SEMA4F Gene

Sources for SEMA4F Gene

Loading form....