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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEMA4F Gene

protein-coding   GIFtS: 57
GCID: GC02P074793

sema domain, immunoglobulin domain (Ig), transmembrane domain...


(Previous symbol: SEMAM)
 Explore 2 diseases affiliated with
SEMA4F via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SEMA4F    

Aliases
for SEMA4F gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short
Cytoplasmic Domain, (Semaphorin) 4F1 2
     Semaphorin-4F1
SEMAW1 2 3 5     Semaphorin-M3
SEMAM1 2 3     Semaphorin-W3
M-SEMA2     Semaphorin-M3
PRO23532     Semaphorin-W3
S4F2     Sema M3
M-Sema-M1     Sema W3
Semaphorin M2     

External Ids:    HGNC: 107341   Entrez Gene: 105052   Ensembl: ENSG000001356227   OMIM: 6037065   UniProtKB: O957543   

Export aliases for SEMA4F gene to outside databases

Previous GC identifers: GC01P099863 GC02P075094 GC02P074839 GC02P074855 GC02P074618


Summaries
for SEMA4F gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SEMA4F:
This gene encodes a transmembrane class IV semaphorin family protein, which plays a role in neural development. This
gene may be involved in neurogenesis in prostate cancer, the development of neurofibromas, and breast cancer
tumorigenesis. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Nov 2012)

UniProtKB/Swiss-Prot: SEM4F_HUMAN, O95754
Function: Has growth cone collapse activity against retinal ganglion-cell axons (By similarity)

Gene Wiki entry for SEMA4F


Genomic Views
for SEMA4F gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEMA4F gene promoter:
         COUP-TF1   AML1a   Pax-5   Tal-1   COUP   HNF-4alpha2   HNF-4alpha1   COUP-TF   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SEMA4F promoter sequence
   Search SABiosciences Chromatin IP Primers for SEMA4F

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA4F


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.1   Ensembl cytogenetic band:  2p13.1   HGNC cytogenetic band: 2p13.1

SEMA4F Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA4F gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P074793:  view genomic region     (about GC identifiers)

Start:
 74,881,355 bp from pter      End:
 74,909,186 bp from pter
Size:
 27,832 bases      Orientation:
 plus strand

Proteins
for SEMA4F gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SEM4F_HUMAN, O95754 (See protein sequence)
Recommended Name: Semaphorin-4F precursor  
Size: 770 amino acids; 83511 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q542Y7 Q9NS35
Alternative splicing: 2 isoforms:  O95754-1   O95754-2   

Explore the universe of human proteins at neXtProt for SEMA4F: NX_O95754

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95754

    • SEMA4F Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001258590.1  NP_001258591.1  NP_004254.2  

    ENSEMBL proteins: 
     ENSP00000350547   ENSP00000416490   ENSP00000413882   ENSP00000342675   ENSP00000407698  
     ENSP00000396703   ENSP00000409141   ENSP00000413916  

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    Novus Biologicals SEMA4F Protein
    Novus Biologicals SEMA4F Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SEMA4F

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000299integral to membrane of membrane fraction ----
    GO:0005624membrane fraction ----
    GO:0005783endoplasmic reticulum IDA--
    GO:0005886plasma membrane TAS10051670
    GO:0005887integral to plasma membrane TAS10051670


    SEMA4F for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SEMA4F gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SEMA4F for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR003659 Plexin-like
     IPR002165 Plexin_repeat
     IPR016201 Plexin-like_fold
     IPR015512 Seamphorin_4F
     IPR027231 Semaphorin

    Graphical View of Domain Structure for InterPro Entry O95754

    ProtoNet protein and cluster: O95754

    1 Blocks protein family: IPB001627 Semaphorin/CD100 antigen

    UniProtKB/Swiss-Prot: SEM4F_HUMAN, O95754
    Similarity: Belongs to the semaphorin family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 PSI domain
    Similarity: Contains 1 Sema domain


    Function
    for SEMA4F gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SEM4F_HUMAN, O95754
    Function: Has growth cone collapse activity against retinal ganglion-cell axons (By similarity)

         Genatlas biochemistry entry for SEMA4F:
    semaphorin 4F,expressed at low levels in the developing embryo and at high levels in the adult central nervous system
    and lung,repellent of the nerve growth cone guidance

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA4F
    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA4F (see all 47):
    hsa-let-7d hsa-miR-513a-5p hsa-miR-1260b hsa-miR-500a hsa-miR-449a hsa-let-7g hsa-miR-3142 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmid: SEMA4F 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA4F (see all 7)
    OriGene shRNA RFP: SEMA4F
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA4F

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SEMA4F

    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----


    SEMA4F for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for SEMA4F:
     Increased S DNA content  Synthetic lethal with Ras 


    Pathways & Interactions
    for SEMA4F gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Axon guidance
    		Axon guidance1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for SEMA4F):
        Axon guidance


    SEMA4F for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SEMA4F

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for SEMA4F (O957543 ENSP000003505474) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NRP2O604623, ENSP000003535824I2D: score=2 STRING: ENSP00000353582
    DLG4P783523, ENSP000002938134I2D: score=1 STRING: ENSP00000293813
    PLXNB1ENSP000002964404STRING: ENSP00000296440
    PLXNB2ENSP000003522884STRING: ENSP00000352288
    PLXNB3ENSP000003553784STRING: ENSP00000355378
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007267cell-cell signaling TAS10051670
    GO:0007399nervous system development TAS10051670
    GO:0007411axon guidance TAS10051670
    GO:0030517negative regulation of axon extension IEA--
    GO:0031290retinal ganglion cell axon guidance IEA--


    SEMA4F for ontologies           About GeneDecksing



    Drugs & Compounds
    for SEMA4F gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEMA4F
    Search CenterWatch for drugs/clinical trials and news about SEMA4F / SEM4F 

    Transcripts
    for SEMA4F gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SEMA4F gene (3 alternative transcripts): 
    NM_001271661.1  NM_001271662.1  NM_004263.4  

    Unigene Cluster for SEMA4F:

    Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
    Hs.25887  [show with all ESTs]
    Unigene Representative Sequence: NM_004263
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357877(uc010ysb.1 uc021vjn.1 uc010ffq.1 uc002sna.1 uc010ffr.1 uc002snb.1 uc002snc.1)
    ENST00000420077 ENST00000458114 ENST00000339773 ENST00000434486 ENST00000416236
    ENST00000453930 ENST00000446927 ENST00000473350

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA4F
    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA4F (see all 47):
    hsa-let-7d hsa-miR-513a-5p hsa-miR-1260b hsa-miR-500a hsa-miR-449a hsa-let-7g hsa-miR-3142 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmid: SEMA4F 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA4F (see all 7)
    OriGene shRNA RFP: SEMA4F
    OriGene siRNA: SEMA4F
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA4F
    Clone
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    GenScript: all cDNA clones in your preferred vector: SEMA4F (NM_004263)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA4F
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA4F

    Additional cDNA sequence: 

    AB021292.1 AB022317.1 AF053369.1 AK075384.1 AK095587.1 AK291023.1 AK304358.1 AK308166.1 
    AK312728.1 AL136552.1 BC018361.1 BC038411.1 NR_073398.1 NR_073399.1 

    9 DOTS entries:

    DT.107478  DT.100024488  DT.102822463  DT.92423256  DT.99993166  DT.100751727  DT.95153855  DT.102822462 
    DT.95161449 

    24/86 AceView cDNA sequences (see all 86):

    NM_004263 BC018361 BE464822 AI289278 AB022317 BM833881 CA423139 AW953466 
    AL136552 BU618204 BM704458 AW206442 BU736624 AK075384 AW957134 CD673852 
    BM987806 BC038411 BG774505 BE504297 BG323723 CA446774 F08995 BQ213659 

    GeneLoc Exon Structure


    Expression
    for SEMA4F gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEMA4F expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCTCTAGGCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SEMA4F expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyRenal VesicleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SEMA4F Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEMA4F

    SOURCE GeneReport for Unigene cluster: Hs.25887
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    In Situ
    Assay Products:     
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    Orthologs
    for SEMA4F gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SEMA4F gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia SEMA4F6
    SEMA3F6
    		 --
    		 50(a)
    27(a)
    		 1 ↔ 1
    possible ortholog
    		 GL344170.1(33541-47086)
    GL343512.1(1500-9205)
    zebrafish
    (Danio rerio)    		 Actinopterygii BX957253.26
    		 --
    		 40(a)
    		 1 ↔ 1
    		 7(65850912-65972937)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Sema-2b6
    Sema-2a6
    		 Sema-2a
    		 21(a)
    21(a)
    		 possible ortholog
    possible ortholog
    		 2R(12274029-12319263)
    2R(12387701-12420934)
    worm
    (Caenorhabditis elegans)    		 Secernentea mab-206
    smp-26
    		 SeMaPhorin related family member (smp-2)
    		 20(a)
    19(a)
    		 possible ortholog
    possible ortholog
    		 I(1644590-1651382)
    I(3667127-3671705)


    ENSEMBL Gene Tree for SEMA4F (if available)
    TreeFam Gene Tree for SEMA4F (if available) 

    Paralogs
    for SEMA4F gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEMA4F gene
    SEMA3C2  SEMA3E2  SEMA4B2  SEMA3F2  SEMA4C2  SEMA4A2  SEMA4G2  SEMA4D2  
    SEMA3A2  SEMA3G2  SEMA3D2  
    15 SIMAP similar genes for SEMA4F using alignment to 7 protein entries:     SEM4F_HUMAN (see all proteins):
    SEMA4D    DKFZp686A04130    SEMA3E    SEMA5A    SEMA4D variant protein    SEMA6A
    SEMA4C    DKFZp686D04248    SEMA3A    SEMA4A    SEMA6D    SEMA3B
    SEMA4G    SEMA4B    SEMA3D

    SEMA4F for paralogs           About GeneDecksing



    Genomic Variants
    for SEMA4F gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/560 NCBI SNPs in SEMA4F are shown (see all 560)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1463648981,2
    		--74879530(+) CCTGAA/GCTATG 5 -- us2k10--------
    rs1905623151,2
    		--74879557(+) AAGGAC/TGGATT 5 -- us2k10--------
    rs1391676201,2
    		--74879695(+) GTCCCA/CTTCCA 5 -- us2k10--------
    rs1440501581,2
    		--74879716(+) GGGCTA/GCCCTG 5 -- us2k10--------
    rs1818891331,2
    		--74879879(+) ATTCAC/TGTGGA 5 -- us2k10--------
    rs1383026751,2
    		--74879907(+) GCCAA-/CCC   
      CCCCCC    CAGCC     		5 -- us2k10--------
    rs1862206391,2
    		--74879997(+) TGCCCC/TGTTTG 5 -- us2k10--------
    rs1889779581,2
    		--74880071(+) TTTCTA/GACGCA 5 -- us2k10--------
    rs1815181201,2
    		--74880141(+) AGCAAA/TTCGAA 5 -- us2k10--------
    rs1147954061,2
    		--74880217(+) TTGTTT/CTGCAG 5 -- us2k11Minor allele frequency- C:0.01NA 120

    HapMap Linkage Disequilibrium report for SEMA4F (74881355 - 74909186 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SEMA4F
         1 Indel: 59003

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for SEMA4F gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SEMA4F for disorders           About GeneDecksing

    OMIM gene information: 603706    OMIM disorders: --

    2 diseases for SEMA4F:    About MalaCards
    dyslexia    retinitis

    Genetic Association Database (GAD): SEMA4F

    Export disorders for SEMA4F gene to outside databases

    Publications
    for SEMA4F gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEMA4F gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with SEMA4F)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression, and genetic mapping of Sema W, a member of the semaphorin family. (PubMed id 10051670)1, 2, 3 Encinas J.A....Kimura T. (1999)
    2. Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1. (PubMed id 11901358)1, 4, 9 Francks C....Monaco A.P. (2002)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    7. NF1 loss disrupts Schwann cell-axonal interactions: a novel role for semaphorin 4F. (PubMed id 19056885)1, 9 Parrinello S....Lloyd A.C. (2008)
    8. Comprehensive gene and microRNA expression profiling r eveals the crucial role of hsa-let-7i and its target genes in colorectal cancer metastasis. (PubMed id 21625861)1 Zhang P....Qin H. (2012)
    9. Expression of Semaphorin 4F in neurons and brain oligo dendrocytes and the regulation of oligodendrocyte precursor migration in the opt ic nerve. (PubMed id 21945643)1 Armendariz B.G....Burgaya F. (2012)
    10. Genetic variants on chromosome 1q41 influence ocular a xial length and high myopia. (PubMed id 22685421)1 Fan Q....Saw S.M. (2012)

    External Searches for SEMA4F gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing SEMA4F gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10505 HGNC: 10734 AceView: SEMA4F Ensembl:ENSG00000135622 euGenes: HUgn10505
    ECgene: SEMA4F Kegg: 10505 H-InvDB: SEMA4F

    Other Databases showing SEMA4F gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SEMA4F gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEMA4F Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SEMA4F Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SEMA4F gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SEMA4F gene:
    Search GeneIP for patents involving SEMA4F

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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