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SEMA4C Gene

protein-coding   GIFtS: 56
GCID: GC02M097525

Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain...


(Previous symbol: SEMAI)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And
Short Cytoplasmic Domain, (Semaphorin) 4C1 2
     SEMACL12
SEMAI1 2 3     SEMAF2
M-Sema F1 2     semaphorin-4C2
M-SEMA-F2     KIAA17393

External Ids:    HGNC: 107311   Entrez Gene: 549102   Ensembl: ENSG000001687587   OMIM: 6044625   UniProtKB: Q9C0C43   

Export aliases for SEMA4C gene to outside databases

Previous GC identifers: GC02M095302 GC02M095979 GC02M096993 GC02M097010 GC02M096947 GC02M096889 GC02M091485


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SEMA4C Gene:
SEMA4C (sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C) is a protein-coding gene. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA3C.

UniProtKB/Swiss-Prot: SEM4C_HUMAN, Q9C0C4
Function: Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding
promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain
development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role
in myogenic differentiation through activation of the stress-activated MAPK cascade

Gene Wiki entry for SEMA4C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEMA4C gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   AhR   STAT5B   oct-B3   oct-B2   POU2F2   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEMA4C promoter sequence
   Search Chromatin IP Primers for SEMA4C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEMA4C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.2

SEMA4C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA4C gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M097525:  view genomic region     (about GC identifiers)

Start:
97,525,453 bp from pter      End:
97,536,494 bp from pter
Size:
11,042 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SEM4C_HUMAN, Q9C0C4 (See protein sequence)
Recommended Name: Semaphorin-4C precursor  
Size: 833 amino acids; 92623 Da
Subunit: Interacts (via the PDZ-binding motif) with GIPC (via the PDZ domain) (By similarity). Interacts with NCDN
(By similarity). Interacts (via the PDZ-binding motif) with DLG4. Interacts with PLXNB2 (By similarity)
Secondary accessions: Q32MJ3 Q7Z5X0

Explore the universe of human proteins at neXtProt for SEMA4C: NX_Q9C0C4

Explore proteomics data for SEMA4C at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys744
  • Glycosylation2 at Asn106, Asn121, Asn310, Asn419, Asn522, Asn564
  • Modification sites at PhosphoSitePlus

  • See SEMA4C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060259.4  
    ENSEMBL proteins: 
     ENSP00000306844   ENSP00000393498   ENSP00000391094  

    SEMA4C Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for SEMA4C
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    Novus Biologicals SEMA4C Protein
    Novus Biologicals SEMA4C Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEMA4C

     
    Search eBioscience for Proteins for SEMA4C 

    SEMA4C Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for SEMA4C (Semaphorin 4C)
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    Novus Biologicals SEMA4C Antibody
    Abcam antibodies for SEMA4C
    Cloud-Clone Corp. Antibodies for SEMA4C
    Search ThermoFisher Antibodies for SEMA4C
    LSBio Antibodies in human, mouse, rat for SEMA4C

    SEMA4C Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for SEMA4C
    Cloud-Clone Corp. CLIAs for SEMA4C
    Search eBioscience for ELISAs for SEMA4C 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    SEMA: Semaphorins

    Selected InterPro protein domains (see all 8):
     IPR002165 Plexin_repeat
     IPR013783 Ig-like_fold
     IPR027231 Semaphorin
     IPR001627 Semap_dom
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9C0C4

    ProtoNet protein and cluster: Q9C0C4

    2 Blocks protein domains:
    IPB001627 Semaphorin/CD100 antigen
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: SEM4C_HUMAN, Q9C0C4
    Similarity: Belongs to the semaphorin family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 PSI domain
    Similarity: Contains 1 Sema domain


    Find genes that share domains with SEMA4C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEM4C_HUMAN, Q9C0C4
    Function: Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding
    promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain
    development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role
    in myogenic differentiation through activation of the stress-activated MAPK cascade

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SEMA4C           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sema4c):
     cellular  integument  mortality/aging  nervous system  pigmentation 

    Find genes that share phenotypes with SEMA4C           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEMA4C
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SEMA4C

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEMA4C
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEMA4C

    miRNA
    Products:
        
    miRTarBase miRNAs that target SEMA4C:
    hsa-mir-16-5p (MIRT051307), hsa-mir-193b-3p (MIRT041553), hsa-mir-19b-3p (MIRT031208)

    Block miRNA regulation of human, mouse, rat SEMA4C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEMA4C (see all 51):
    hsa-miR-136 hsa-let-7d hsa-miR-449a hsa-miR-570 hsa-let-7g hsa-let-7a hsa-miR-28-5p hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidSEMA4C 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SEMA4C
    Predesigned siRNA for gene silencing in human, mouse, rat SEMA4C

    Gene Editing
    Products:
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    Clone
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    OriGene clones in human, mouse for SEMA4C (see all 8)
    OriGene ORF clones in mouse, rat for SEMA4C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEMA4C (NM_017789)
    Sino Biological Human cDNA Clone for SEMA4C
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA4C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA4C

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SEMA4C 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA4C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SEM4C_HUMAN, Q9C0C4: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density; Single-pass type I
    membrane protein (By similarity). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass
    type I membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane3
    cytosol1
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0014069postsynaptic density ISS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0030054cell junction IEA--

    Find genes that share ontologies with SEMA4C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SEMA4C About    
    See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Axon guidance


    Find genes that share SuperPaths with SEMA4C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for SEMA4C):
        Axon guidance

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEMA4C
    Interactions:

        GeneGlobe Interaction Network for SEMA4C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for SEMA4C (Q9C0C43 ENSP000003068444) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG3Q927963, ENSP000003634804I2D: score=2 STRING: ENSP00000363480
    DLG1Q129593, ENSP000003457314I2D: score=1 STRING: ENSP00000345731
    GIPC2Q8TF653, ENSP000003597954I2D: score=1 STRING: ENSP00000359795
    NCDNQ9UBB63, ENSP000003483944I2D: score=1 STRING: ENSP00000348394
    GIPC1O149083, ENSP000003406984I2D: score=2 STRING: ENSP00000340698
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001843neural tube closure ISS--
    GO:0007275multicellular organismal development ----
    GO:0021535cell migration in hindbrain ISS--
    GO:0021549cerebellum development IEA--
    GO:0032874positive regulation of stress-activated MAPK cascade IDA17498836

    Find genes that share ontologies with SEMA4C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEMA4C (SEM4C)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SEMA4C gene: 
    NM_017789.4  

    Unigene Cluster for SEMA4C:

    Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
    Hs.516220  [show with all ESTs]
    Unigene Representative Sequence: NM_017789
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305476(uc002sxh.4) ENST00000474420 ENST00000482925(uc002sxg.4)
    ENST00000467747(uc002sxf.4 uc002sxe.3) ENST00000442264 ENST00000449330

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SEMA4C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEMA4C (see all 51):
    hsa-miR-136 hsa-let-7d hsa-miR-449a hsa-miR-570 hsa-let-7g hsa-let-7a hsa-miR-28-5p hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidSEMA4C 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SEMA4C
    Predesigned siRNA for gene silencing in human, mouse, rat SEMA4C
    Clone
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    OriGene clones in human, mouse for SEMA4C (see all 8)
    OriGene ORF clones in mouse, rat for SEMA4C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEMA4C (NM_017789)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA4C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA4C
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SEMA4C
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEMA4C
      QuantiTect SYBR Green Assays in human, mouse, rat SEMA4C
      QuantiFast Probe-based Assays in human, mouse, rat SEMA4C

    Additional mRNA sequence: 

    AF258577.1 AK000376.1 AY358842.1 BC017476.1 BC062984.1 BC109103.1 BC109104.1 

    10 DOTS entries:

    DT.442761  DT.101982662  DT.87004199  DT.120945726  DT.91739074  DT.97803902  DT.95231985  DT.100829757 
    DT.40131323  DT.97766009 

    Selected AceView cDNA sequences (see all 124):

    AI926069 BC062984 AF370374 BE612411 CF243117 BQ068313 BM971936 AK000376 
    CB851802 BU855862 NM_017789 AA991513 BU856924 AW468222 BQ926654 BQ932835 
    BM685235 BF109101 T51972 CD518993 BQ646877 AB051526 BC017476 AK075388 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SEMA4C (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18
    SP1:              -           -                                                                             -                 -                     
    SP2:                                                                                                        -                 -                     
    SP3:                          -                                                                                                                     
    SP4:        -     -           -                                                                                                                     
    SP5:                                                                                                                          -                     


    ECgene alternative splicing isoforms for SEMA4C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SEMA4C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTTGTGTG
    SEMA4C Expression
    About this image


    SEMA4C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Tube (Nervous System)
             Metencephalon
    SEMA4C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEMA4C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516220
        Custom PCR Arrays for SEMA4C
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SEMA4C
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEMA4C
    QuantiTect SYBR Green Assays in human, mouse, rat SEMA4C
    QuantiFast Probe-based Assays in human, mouse, rat SEMA4C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA4C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SEMA4C gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sema4c1 , 5 sema domain, immunoglobulin domain (Ig), transmembrane more1, 5 85.35(n)1
    87.88(a)1
      1 (15.32 cM)5
    203531  NM_001126047.21  NP_001119519.11 
     365486425 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    34(a)
    many ↔ many
    28(3448567-3457702) ENSGALG00000003058
    lizard
    (Anolis carolinensis)
    Reptilia SEMA4C6
    sema domain, immunoglobulin domain (Ig), transmemb...
    55(a)
    1 ↔ 1
    GL343484.1(347223-451297)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL860809.22   -- 74.03(n)    AL860809.2 
    zebrafish
    (Danio rerio)
    Actinopterygii sema4e2 semaphorin 4e 78.31(n)   30251  AF073289.1 


    ENSEMBL Gene Tree for SEMA4C (if available)
    TreeFam Gene Tree for SEMA4C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SEMA4C gene
    SEMA3C2  SEMA4F2  SEMA3E2  SEMA4B2  SEMA3F2  SEMA4A2  SEMA4D2  SEMA4G2  
    SEMA3A2  SEMA3G2  SEMA3D2  
    18 SIMAP similar genes for SEMA4C using alignment to 5 protein entries:     SEM4C_HUMAN (see all proteins):
    SEMA4A    SEMA4G    SEMA4D variant protein    SEMA4D    SEMA3B    DKFZp686D04248
    SEMA3C    SEMA6D    SEMA4F    SEMA3E    SEMA4B    SEMA3A
    SEMA3F    PLXNC1    SEMA5A    SEMA3D    SEMA5B    DKFZp686A04130

    Find genes that share paralogs with SEMA4C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SEMA4C (see all 284)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1862819841,2
    --97525812(+) CCACCA/CCAAGC 1 -- ut310--------
    rs1161071731,2
    C--97525962(+) AGGAGG/AACCCA 1 -- ut311Minor allele frequency- A:0.01WA 118
    rs1159474041,2
    F--97526025(+) CGCGTG/ACACAC 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs3717117851,2
    C--97526037(+) CACAT-/AC/CA 
            
    ACACA
    2 -- ut310--------
    rs1387957261,2
    C--97526065(+) CAAAT-/ACAG  
            
    ACAAA
    1 -- ut310--------
    rs2020612831,2
    C,F--97526354(+) GGTGGG/AGGTTC 1 -- ut311Minor allele frequency- A:0.00EU 591
    rs2001623491,2
    C,F--97526357(+) GGGGGT/ATCCCC 1 -- ut311Minor allele frequency- A:0.00EU 575
    rs1996222891,2
    --97526359(+) GGGTTC/TCCCTC 1 -- ut310--------
    rs1887509061,2
    C--97526438(+) TCCGCA/GAGCTC 2 L syn10--------
    rs2012907891,2
    C--97526521(+) GTTCCA/GCCCAC 2 R W mis10--------

    HapMap Linkage Disequilibrium report for SEMA4C (97525453 - 97536494 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SEMA4C:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv650e201CNV Deletion23290073
    dgv4249n71CNV Loss21882294
    nsv874680CNV Loss21882294
    nsv526313CNV Loss19592680
    nsv874677CNV Loss21882294
    esv5003CNV Complex18987735

    Human Gene Mutation Database (HGMD): SEMA4C
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEMA4C
    DNA2.0 Custom Variant and Variant Library Synthesis for SEMA4C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604462    OMIM disorders: --


    Find genes that share disorders with SEMA4C           About GenesLikeMe


    Export disorders for SEMA4C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SEMA4C gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with SEMA4C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sema4C participates in myogenic differentiation in vivo and in vitro through the p38 MAPK pathway. (PubMed id 17498836)1, 2 Wu H.... Fan M. (Eur. J. Cell Biol. 2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    5. Identification of a member of mouse semaphorin family. (PubMed id 7656991)1, 3 Inagaki S....Iwahashi Y. (FEBS Lett. 1995)
    6. [Expression and clinical significance of Sema4C in esophageal cancer, gastric cancer and rectal cancer]. (PubMed id 22944267)1 Ye S.M....Wang S.X. (Zhonghua Yi Xue Za Zhi 2012)
    7. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Role of Sema4C in TGF-I^1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells. (PubMed id 20959347)1 Zeng R....Xu G. (Nephrol. Dial. Transplant. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54910 HGNC: 10731 AceView: SEMA4C Ensembl:ENSG00000168758 euGenes: HUgn54910
    ECgene: SEMA4C Kegg: 54910 H-InvDB: SEMA4C

    (According to HUGE)
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    HUGE: KIAA1739

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SEMA4C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SEMA4C gene:
    Search GeneIP for patents involving SEMA4C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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