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Aliases for SEMA4C Gene

Aliases for SEMA4C Gene

  • Semaphorin 4C 2 3
  • Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4C 2 3 5
  • M-Sema F 2 3
  • SEMAI 3 4
  • M-SEMA-F 3
  • KIAA1739 4
  • SEMACL1 3
  • SEMAF 3

External Ids for SEMA4C Gene

Previous HGNC Symbols for SEMA4C Gene

  • SEMAI

Previous GeneCards Identifiers for SEMA4C Gene

  • GC02M095302
  • GC02M095979
  • GC02M096993
  • GC02M097010
  • GC02M096947
  • GC02M097525
  • GC02M091485

Summaries for SEMA4C Gene

GeneCards Summary for SEMA4C Gene

SEMA4C (Semaphorin 4C) is a Protein Coding gene. Among its related pathways are Axon guidance. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA3F.

UniProtKB/Swiss-Prot for SEMA4C Gene

  • Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at Tyr-1248. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.

Gene Wiki entry for SEMA4C Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMA4C Gene

Genomics for SEMA4C Gene

Regulatory Elements for SEMA4C Gene

Promoters for SEMA4C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SEMA4C on UCSC Golden Path with GeneCards custom track

Genomic Location for SEMA4C Gene

Chromosome:
2
Start:
96,859,716 bp from pter
End:
96,870,943 bp from pter
Size:
11,228 bases
Orientation:
Minus strand

Genomic View for SEMA4C Gene

Genes around SEMA4C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEMA4C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEMA4C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA4C Gene

Proteins for SEMA4C Gene

  • Protein details for SEMA4C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0C4-SEM4C_HUMAN
    Recommended name:
    Semaphorin-4C
    Protein Accession:
    Q9C0C4
    Secondary Accessions:
    • Q32MJ3
    • Q7Z5X0

    Protein attributes for SEMA4C Gene

    Size:
    833 amino acids
    Molecular mass:
    92623 Da
    Quaternary structure:
    • Interacts (via the PDZ-binding motif) with GIPC (via the PDZ domain) (By similarity). Interacts with NCDN (By similarity). Interacts (via the PDZ-binding motif) with DLG4. Interacts with PLXNB2 (By similarity).

neXtProt entry for SEMA4C Gene

Proteomics data for SEMA4C Gene at MOPED

Post-translational modifications for SEMA4C Gene

  • Ubiquitination at Lys 744
  • Glycosylation at Asn 106, Asn 121, Asn 310, Asn 419, Asn 522, and Asn 564
  • Modification sites at PhosphoSitePlus

Other Protein References for SEMA4C Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for SEMA4C (Semaphorin 4C)

No data available for DME Specific Peptides for SEMA4C Gene

Domains & Families for SEMA4C Gene

Suggested Antigen Peptide Sequences for SEMA4C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C0C4

UniProtKB/Swiss-Prot:

SEM4C_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Belongs to the semaphorin family.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 PSI domain.
  • Contains 1 Sema domain.
Family:
  • Belongs to the semaphorin family.
genes like me logo Genes that share domains with SEMA4C: view

Function for SEMA4C Gene

Molecular function for SEMA4C Gene

UniProtKB/Swiss-Prot Function:
Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at Tyr-1248. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.
genes like me logo Genes that share phenotypes with SEMA4C: view

Animal Models for SEMA4C Gene

MGI Knock Outs for SEMA4C:

Animal Model Products

  • Taconic Biosciences Mouse Models for SEMA4C

miRNA for SEMA4C Gene

miRTarBase miRNAs that target SEMA4C

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SEMA4C Gene

Localization for SEMA4C Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA4C Gene

Cell junction, synapse, postsynaptic cell membrane, postsynaptic density; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEMA4C Gene COMPARTMENTS Subcellular localization image for SEMA4C gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SEMA4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014069 postsynaptic density IEA,ISS --
GO:0016021 integral component of membrane IEA --
GO:0045211 postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with SEMA4C: view

Pathways & Interactions for SEMA4C Gene

SuperPathways for SEMA4C Gene

Superpath Contained pathways
1 Axon guidance
genes like me logo Genes that share pathways with SEMA4C: view

Pathways by source for SEMA4C Gene

1 KEGG pathway for SEMA4C Gene

Gene Ontology (GO) - Biological Process for SEMA4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001843 neural tube closure IEA,ISS --
GO:0021535 cell migration in hindbrain IEA,ISS --
GO:0021549 cerebellum development IEA --
GO:0030335 positive regulation of cell migration IBA --
GO:0048843 negative regulation of axon extension involved in axon guidance IBA --
genes like me logo Genes that share ontologies with SEMA4C: view

No data available for SIGNOR curated interactions for SEMA4C Gene

Drugs & Compounds for SEMA4C Gene

No Compound Related Data Available

Transcripts for SEMA4C Gene

Unigene Clusters for SEMA4C Gene

Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA4C Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18
SP1: - - - -
SP2: - -
SP3: -
SP4: - - -
SP5: -
SP6: -

Relevant External Links for SEMA4C Gene

GeneLoc Exon Structure for
SEMA4C
ECgene alternative splicing isoforms for
SEMA4C

Expression for SEMA4C Gene

mRNA expression in normal human tissues for SEMA4C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SEMA4C Gene

This gene is overexpressed in Fetal Brain (23.6), Heart (17.9), Spleen (7.3), and Placenta (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEMA4C Gene



SOURCE GeneReport for Unigene cluster for SEMA4C Gene Hs.516220

genes like me logo Genes that share expression patterns with SEMA4C: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SEMA4C Gene

Orthologs for SEMA4C Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEMA4C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEMA4C 36
  • 100 (a)
OneToOne
SEMA4C 35
  • 96.36 (n)
  • 95.32 (a)
cow
(Bos Taurus)
Mammalia SEMA4C 35
  • 87.43 (n)
  • 93.28 (a)
SEMA4C 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEMA4C 36
  • 93 (a)
OneToOne
SEMA4C 35
  • 88.4 (n)
  • 92.92 (a)
mouse
(Mus musculus)
Mammalia Sema4c 16
Sema4c 35
  • 85.35 (n)
  • 87.88 (a)
Sema4c 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEMA4C 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEMA4C 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sema4c 35
  • 84.83 (n)
  • 87.15 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 34 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia SEMA4C 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sema4c 35
  • 62.89 (n)
  • 60.34 (a)
zebrafish
(Danio rerio)
Actinopterygii sc:d411 35
  • 60.49 (n)
  • 57.55 (a)
sema4e 35
SEMA4C 36
  • 54 (a)
OneToOne
Species with no ortholog for SEMA4C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEMA4C Gene

ENSEMBL:
Gene Tree for SEMA4C (if available)
TreeFam:
Gene Tree for SEMA4C (if available)

Paralogs for SEMA4C Gene

genes like me logo Genes that share paralogs with SEMA4C: view

Variants for SEMA4C Gene

Sequence variations from dbSNP and Humsavar for SEMA4C Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs6752156 -- 96,871,357(+) GTGGG(C/G)AGGGA upstream-variant-2KB
rs6758174 -- 96,862,628(+) gaggc(C/T)gagtc intron-variant
rs7566053 -- 96,863,659(+) CAGTG(A/G)CAGAT intron-variant
rs7604991 -- 96,867,066(+) GCATG(C/T)AGGGC intron-variant
rs12471298 -- 96,861,051(+) CAGCT(A/C)TTCCC reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for SEMA4C Gene

Variant ID Type Subtype PubMed ID
dgv650e201 CNV Deletion 23290073
esv5003 CNV Complex 18987735
nsv874677 CNV Loss 21882294
nsv874680 CNV Loss 21882294
nsv526313 CNV Loss 19592680
dgv4249n71 CNV Loss 21882294

Variation tolerance for SEMA4C Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.98; 68.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEMA4C Gene

HapMap Linkage Disequilibrium report
SEMA4C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEMA4C Gene

Disorders for SEMA4C Gene

Relevant External Links for SEMA4C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEMA4C

No disorders were found for SEMA4C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEMA4C Gene

Publications for SEMA4C Gene

  1. Sema4C participates in myogenic differentiation in vivo and in vitro through the p38 MAPK pathway. (PMID: 17498836) Wu H. … Fan M. (Eur. J. Cell Biol. 2007) 3 4 67
  2. Identification of a member of mouse semaphorin family. (PMID: 7656991) Inagaki S. … Iwahashi Y. (FEBS Lett. 1995) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Erbin interacts with Sema4C and inhibits Sema4C-induced epithelial-mesenchymal transition in HK2 cells. (PMID: 24142719) Zhou Q.D. … Xu G. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2013) 3

Products for SEMA4C Gene

Sources for SEMA4C Gene

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