Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEMA4C Gene

protein-coding   GIFtS: 52
GCID: GC02M097525

sema domain, immunoglobulin domain (Ig), transmembrane domain...


(Previous symbol: SEMAI)
 Explore 3 diseases affiliated with
SEMA4C via our new
 Human Malady Compendium 
Biological research products
for SEMA4C
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short
Cytoplasmic Domain, (Semaphorin) 4C1 2
     SEMACL12
SEMAI1 2 3     SEMAF2
Semacl11     M-Sema F2
Semaf1     Semaphorin-4C1
M-SEMA-F2     KIAA17393

External Ids:    HGNC: 107311   Entrez Gene: 549102   Ensembl: ENSG000001687587   OMIM: 6044625   UniProtKB: Q9C0C43   

Export aliases for SEMA4C gene to outside databases

Previous GC identifers: GC02M095302 GC02M095979 GC02M096993 GC02M097010 GC02M096947 GC02M096889 GC02M091485


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SEM4C_HUMAN, Q9C0C4
Function: Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes
downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon
guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic
differentiation through activation of the stress-activated MAPK cascade

Gene Wiki entry for SEMA4C


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022171.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEMA4C gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   AhR   STAT5B   oct-B3   oct-B2   POU2F2   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEMA4C promoter sequence
   Search SABiosciences Chromatin IP Primers for SEMA4C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA4C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.2

SEMA4C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA4C gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M097525:  view genomic region     (about GC identifiers)

Start:
97,525,453 bp from pter      End:
97,536,494 bp from pter
Size:
11,042 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SEM4C_HUMAN, Q9C0C4 (See protein sequence)
Recommended Name: Semaphorin-4C precursor  
Size: 833 amino acids; 92623 Da
Subunit: Interacts (via the PDZ-binding motif) with GIPC (via the PDZ domain) (By similarity). Interacts with NCDN (By
similarity). Interacts (via the PDZ-binding motif) with DLG4. Interacts with PLXNB2 (By similarity)
Subcellular location: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density; Single-pass type I
membrane protein (By similarity). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type
I membrane protein (By similarity)
Secondary accessions: Q32MJ3 Q7Z5X0

Explore the universe of human proteins at neXtProt for SEMA4C: NX_Q9C0C4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9C0C4

  • SEMA4C Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060259.4  
    ENSEMBL proteins: 
     ENSP00000306844   ENSP00000393498   ENSP00000391094  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: SEMA4C
    OriGene Custom Protein Services for SEMA4C 
    GenScript Custom Purified and Recombinant Proteins Services for SEMA4C
    Novus Biologicals SEMA4C Protein
    Novus Biologicals SEMA4C Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SEMA4C

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0014069postsynaptic density ISS--
    GO:0016021integral to membrane IEA--
    GO:0030054cell junction IEA--
    GO:0030672synaptic vesicle membrane ISS--


    SEMA4C for ontologies           About GeneDecksing



    SEMA4C Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for SEMA4C (Semaphorin 4C)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SEMA4C 
    GenScript Custom Superior Antibodies Services for SEMA4C
    Novus Biologicals SEMA4C Antibody
    Search for Antibodies for SEMA4C at Abcam  
    Uscn Antibodies for SEMA4C
    Search ThermoFisher Antibodies for SEMA4C

    Assay Products for SEMA4C: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SEMA4C
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SEMA4C


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SEMA4C for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR007110 Ig-like_dom
     IPR003659 Plexin-like
     IPR003599 Ig_sub
     IPR002165 Plexin_repeat
     IPR016201 Plexin-like_fold

    Graphical View of Domain Structure for InterPro Entry Q9C0C4

    ProtoNet protein and cluster: Q9C0C4

    2 Blocks protein families:
    IPB001627 Semaphorin/CD100 antigen
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: SEM4C_HUMAN, Q9C0C4
    Similarity: Belongs to the semaphorin family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 PSI domain
    Similarity: Contains 1 Sema domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SEM4C_HUMAN, Q9C0C4
    Function: Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes
    downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon
    guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic
    differentiation through activation of the stress-activated MAPK cascade

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: SEMA4C
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA4C
    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA4C (see all 51):
    hsa-miR-136 hsa-let-7d hsa-miR-449a hsa-miR-570 hsa-let-7g hsa-let-7a hsa-miR-28-5p hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidSEMA4C 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA4C (see all 7)
    OriGene shRNA RFP: SEMA4C
    OriGene siRNA: SEMA4C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA4C

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SEMA4C

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA4C (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA4C (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SEMA4C (NM_017789)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA4C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA4C 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SEMA4C
    Search LifeMap BioReagents cell lines for SEMA4C

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA4C

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----


    SEMA4C for ontologies           About GeneDecksing


    Animal Models:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sema4c):
     cellular  integument  mortality/aging  nervous system  pigmentation 

    SEMA4C for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Axon guidance
    Axon guidance1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for SEMA4C):
        Axon guidance


    SEMA4C for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SEMA4C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/11 Interacting proteins for SEMA4C (Q9C0C43 ENSP000003068444) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG4P783523, ENSP000002938134I2D: score=3 STRING: ENSP00000293813
    DLG3Q927963, ENSP000003634804I2D: score=2 STRING: ENSP00000363480
    DLG1Q129593, ENSP000003457314I2D: score=1 STRING: ENSP00000345731
    NCDNQ9UBB63, ENSP000003483944I2D: score=1 STRING: ENSP00000348394
    GIPC1O149083, ENSP000003406984I2D: score=2 STRING: ENSP00000340698
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001843neural tube closure ISS--
    GO:0021535cell migration in hindbrain ISS--
    GO:0021549cerebellum development IEA--
    GO:0032874positive regulation of stress-activated MAPK cascade IDA17498836
    GO:0042692muscle cell differentiation IDA17498836


    SEMA4C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEMA4C
    Search CenterWatch for drugs/clinical trials and news about SEMA4C / SEM4C 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SEMA4C gene: 
    NM_017789.4  

    Unigene Cluster for SEMA4C:

    Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
    Hs.516220  [show with all ESTs]
    Unigene Representative Sequence: NM_017789
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305476(uc002sxh.4) ENST00000474420 ENST00000482925(uc002sxg.4)
    ENST00000467747(uc002sxf.4 uc002sxe.3) ENST00000442264 ENST00000449330


    miRNA
    Products:
         
    OriGene 3'-UTR Clone: SEMA4C
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA4C
    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA4C (see all 51):
    hsa-miR-136 hsa-let-7d hsa-miR-449a hsa-miR-570 hsa-let-7g hsa-let-7a hsa-miR-28-5p hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidSEMA4C 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA4C (see all 7)
    OriGene shRNA RFP: SEMA4C
    OriGene siRNA: SEMA4C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA4C
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA4C (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA4C (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SEMA4C (NM_017789)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA4C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA4C 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEMA4C
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEMA4C
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA4C
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA4C

    Additional cDNA sequence: 

    AF258577.1 AK000376.1 AY358842.1 BC017476.1 BC062984.1 BC109103.1 BC109104.1 

    10 DOTS entries:

    DT.442761  DT.101982662  DT.87004199  DT.120945726  DT.91739074  DT.97803902  DT.95231985  DT.100829757 
    DT.40131323  DT.97766009 

    24/124 AceView cDNA sequences (see all 124):

    BC062984 AF370374 AI926069 BU856924 BE302196 BM971936 T51972 AK000376 
    CF243117 BQ646877 BQ926654 AB051526 AK075388 AA991513 BQ651466 BM685235 
    AI864089 BQ932835 BF109101 CD518993 CB851802 BC017476 BE612411 BU855862 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SEMA4C (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18
    SP1:              -           -                                                                             -                 -                     
    SP2:                                                                                                        -                 -                     
    SP3:                          -                                                                                                                     
    SP4:        -     -           -                                                                                                                     
    SP5:                                                                                                                          -                     


    ECgene alternative splicing isoforms for SEMA4C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEMA4C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTTTGTGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SEMA4C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEMA4C

    SOURCE GeneReport for Unigene cluster: Hs.516220
        SABiosciences Custom PCR Arrays for SEMA4C
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEMA4C
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEMA4C
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA4C
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA4C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA4C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SEMA4C gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    SEMA4C6
    (see all 3)
    --
    62(a)
    56(a)
    (see all 3)
    possible ortholog
    1 ↔ 1
    (see all 3)
    AAWZ02039418(2653-6879)
    GL343484.1(419566-451297)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL860809.22   -- 74.03(n)    AL860809.2 
    zebrafish
    (Danio rerio)
    Actinopterygii sema4e2 semaphorin 4e 78.31(n)   30251  AF073289.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sema-2a6
    Sema-2b6
    Semaphorin-2b
    23(a)
    22(a)
    possible ortholog
    possible ortholog
    2R(12387701-12420934)
    2R(12274029-12319263)
    worm
    (Caenorhabditis elegans)
    Secernentea mab-206
    smp-26
    SeMaPhorin related family member (smp-2)
    23(a)
    17(a)
    possible ortholog
    possible ortholog
    I(1644590-1651382)
    I(3667127-3671705)


    ENSEMBL Gene Tree for SEMA4C (if available)
    TreeFam Gene Tree for SEMA4C (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEMA4C gene
    SEMA3C2  SEMA4F2  SEMA3E2  SEMA4B2  SEMA3F2  SEMA4A2  SEMA4G2  SEMA4D2  
    SEMA3A2  SEMA3G2  SEMA3D2  
    18 SIMAP similar genes for SEMA4C using alignment to 5 protein entries:     SEM4C_HUMAN (see all proteins):
    SEMA4A    SEMA4G    SEMA4D variant protein    SEMA4D    SEMA3B    DKFZp686D04248
    SEMA3C    SEMA6D    SEMA4F    SEMA3E    SEMA4B    SEMA3A
    SEMA3F    PLXNC1    SEMA5A    SEMA3D    SEMA5B    DKFZp686A04130

    SEMA4C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/185 NCBI SNPs in SEMA4C are shown (see all 185    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1862819841,2
    --97525812(+) CCACCA/CCAAGC 1 -- ut310--------
    rs1161071731,2
    C,--97525962(+) AGGAGG/AACCCA 1 -- ut311Minor allele frequency- A:0.01WA 118
    rs1159474041,2
    F,--97526025(+) CGCGTG/ACACAC 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs1387957261,2
    C,--97526065(+) CAAAT-/ACAG  
            
    ACAAA
    1 -- ut310--------
    rs2020612831,2
    F--97526354(+) GGTGGG/AGGTTC 1 -- ut311Minor allele frequency- A:0.00EU 591
    rs2001623491,2
    F--97526357(+) GGGGGT/ATCCCC 1 -- ut311Minor allele frequency- A:0.00EU 575
    rs1996222891,2
    --97526359(+) GGGTTC/TCCCTC 1 -- ut310--------
    rs1887509061,2
    C,--97526438(+) TCCGCA/GAGCTC 2 L syn10--------
    rs2012907891,2
    C,--97526521(+) GTTCCA/GCCCAC 2 R W mis10--------
    rs2005267851,2
    --97526534(+) CCCAGA/GTGAAG 2 H syn10--------

    HapMap Linkage Disequilibrium report for SEMA4C (97525453 - 97536494 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SEMA4C: --
    Human Gene Mutation Database (HGMD): SEMA4C

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEMA4C
    DNA2.0 Custom Variant and Variant Library Synthesis for SEMA4C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SEMA4C for disorders           About GeneDecksing

    OMIM gene information: 604462    OMIM disorders: --

    3 diseases for SEMA4C:    About MalaCards
    cri-du-chat syndrome    night blindness    blindness


    Export disorders for SEMA4C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEMA4C gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with SEMA4C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sema4C participates in myogenic differentiation in vivo and in vitro through the p38 MAPK pathway. (PubMed id 17498836)1, 2 Wu H.... Fan M. (2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (2000)
    5. Identification of a member of mouse semaphorin family. (PubMed id 7656991)1, 3 Inagaki S....Iwahashi Y. (1995)
    6. Role of Sema4C in TGF-I^1-induced mitogen-activated pr otein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells. (PubMed id 20959347)1 Zeng R....Xu G. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Semaphorin 4B interacts with the post-synaptic density protein PSD-95/SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif. (PubMed id 15978582)1 Burkhardt C....Puschel A.W. (2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54910 HGNC: 10731 AceView: SEMA4C Ensembl:ENSG00000168758 euGenes: HUgn54910
    ECgene: SEMA4C Kegg: 54910 H-InvDB: SEMA4C

    (According to HUGE)
    About This Section
    HUGE: KIAA1739

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEMA4C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEMA4C gene:
    Search GeneIP for patents involving SEMA4C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for SEMA4C (Semaphorin 4C)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SEMA4C  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA4C   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEMA4C  
     OriGene Protein Over-expression Lysate for SEMA4C   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SEMA4C   OriGene 3'-UTR Clone for SEMA4C  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA4C   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA4C  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SEMA4C   OriGene Custom Protein Services for SEMA4C  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SEMA4C
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEMA4C
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA4C
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA4C
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA4C
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA4C
     GenScript Custom Purified and Recombinant Proteins Services for SEMA4C GenScript cDNA clones with any tag delivered in your preferred vector for SEMA4C
     GenScript Custom Assay Services for SEMA4C GenScript Custom Superior Antibodies Services for SEMA4C
     GenScript Custom overexpressing Cell Line Services for SEMA4C CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SEMA4C promoter
     Search Chromatin IP Primers for SEMA4C
     RT2 qPCR Primer Assay in human, mouse, rat SEMA4C
     GNC Network for SEMA4C
     SABiosciences Custom PCR Arrays for SEMA4C
     Search Tocris compounds for SEMA4C
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SEMA4C antibodies
     SEMA4C proteins
     SEMA4C lysates
     Search for Antibodies for SEMA4C at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SEMA4C
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SEMA4C Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SEMA4C
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA4C
     SwitchGear 3'UTR luciferase reporter plasmids for SEMA4C
     SwitchGear Promoter luciferase reporter plasmids for SEMA4C
     Search ThermoFisher Antibodies for SEMA4C
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA4C
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SEMA4C gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4