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Aliases for SEMA4C Gene

Aliases for SEMA4C Gene

  • Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4C 2 3
  • M-Sema F 2 3
  • SEMAI 3 4
  • Semaphorin-4C 3
  • M-SEMA-F 3
  • KIAA1739 4
  • SEMACL1 3
  • SEMAF 3

External Ids for SEMA4C Gene

Previous HGNC Symbols for SEMA4C Gene

  • SEMAI

Previous GeneCards Identifiers for SEMA4C Gene

  • GC02M095302
  • GC02M095979
  • GC02M096993
  • GC02M097010
  • GC02M096947
  • GC02M097525
  • GC02M091485

Summaries for SEMA4C Gene

GeneCards Summary for SEMA4C Gene

SEMA4C (Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4C) is a Protein Coding gene. Diseases associated with SEMA4C include esophageal cancer. Among its related pathways are Axon guidance. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA4G.

UniProtKB/Swiss-Prot for SEMA4C Gene

  • Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at Tyr-1248. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.

Gene Wiki entry for SEMA4C Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMA4C Gene

Genomics for SEMA4C Gene

Regulatory Elements for SEMA4C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SEMA4C Gene

Start:
96,859,716 bp from pter
End:
96,870,757 bp from pter
Size:
11,042 bases
Orientation:
Minus strand

Genomic View for SEMA4C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEMA4C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA4C Gene

Proteins for SEMA4C Gene

  • Protein details for SEMA4C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0C4-SEM4C_HUMAN
    Recommended name:
    Semaphorin-4C
    Protein Accession:
    Q9C0C4
    Secondary Accessions:
    • Q32MJ3
    • Q7Z5X0

    Protein attributes for SEMA4C Gene

    Size:
    833 amino acids
    Molecular mass:
    92623 Da
    Quaternary structure:
    • Interacts (via the PDZ-binding motif) with GIPC (via the PDZ domain) (By similarity). Interacts with NCDN (By similarity). Interacts (via the PDZ-binding motif) with DLG4. Interacts with PLXNB2 (By similarity).

neXtProt entry for SEMA4C Gene

Proteomics data for SEMA4C Gene at MOPED

Post-translational modifications for SEMA4C Gene

  • Ubiquitination at Lys744
  • Glycosylation at Asn106, Asn121, Asn310, Asn419, Asn522, and Asn564
  • Modification sites at PhosphoSitePlus

Other Protein References for SEMA4C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SEMA4C Gene

Domains for SEMA4C Gene

Gene Families for SEMA4C Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • SEMA :Semaphorins

Suggested Antigen Peptide Sequences for SEMA4C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C0C4

UniProtKB/Swiss-Prot:

SEM4C_HUMAN :
  • Q9C0C4
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 PSI domain.
  • Contains 1 Sema domain.
Family:
  • Belongs to the semaphorin family.
genes like me logo Genes that share domains with SEMA4C: view

Function for SEMA4C Gene

Molecular function for SEMA4C Gene

UniProtKB/Swiss-Prot Function: Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at Tyr-1248. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.

Gene Ontology (GO) - Molecular Function for SEMA4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SEMA4C: view
genes like me logo Genes that share phenotypes with SEMA4C: view

Animal Model Products

CRISPR Products

miRNA for SEMA4C Gene

miRTarBase miRNAs that target SEMA4C

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEMA4C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEMA4C Gene

Localization for SEMA4C Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA4C Gene

Cell junction, synapse, postsynaptic cell membrane, postsynaptic density; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEMA4C Gene COMPARTMENTS Subcellular localization image for SEMA4C gene
Compartment Confidence
cytoskeleton 5
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SEMA4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0014069 postsynaptic density ISS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with SEMA4C: view

Pathways for SEMA4C Gene

SuperPathways for SEMA4C Gene

Superpath Contained pathways
1 Axon guidance
genes like me logo Genes that share pathways with SEMA4C: view

Pathways by source for SEMA4C Gene

1 KEGG pathway for SEMA4C Gene

Gene Ontology (GO) - Biological Process for SEMA4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001843 neural tube closure ISS --
GO:0007275 multicellular organismal development --
GO:0021535 cell migration in hindbrain ISS --
GO:0021549 cerebellum development IEA --
GO:0032874 positive regulation of stress-activated MAPK cascade IDA 17498836
genes like me logo Genes that share ontologies with SEMA4C: view

Transcripts for SEMA4C Gene

Unigene Clusters for SEMA4C Gene

Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEMA4C

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SEMA4C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA4C Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18
SP1: - - - -
SP2: - -
SP3: -
SP4: - - -
SP5: -
SP6: -

Relevant External Links for SEMA4C Gene

GeneLoc Exon Structure for
SEMA4C
ECgene alternative splicing isoforms for
SEMA4C

Expression for SEMA4C Gene

mRNA expression in normal human tissues for SEMA4C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEMA4C Gene

SOURCE GeneReport for Unigene cluster for SEMA4C Gene Hs.516220

genes like me logo Genes that share expressions with SEMA4C: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SEMA4C Gene

Orthologs for SEMA4C Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEMA4C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEMA4C 35
  • 96.36 (n)
  • 95.32 (a)
SEMA4C 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SEMA4C 35
  • 87.43 (n)
  • 93.28 (a)
SEMA4C 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEMA4C 35
  • 88.4 (n)
  • 92.92 (a)
SEMA4C 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sema4c 35
  • 85.35 (n)
  • 87.88 (a)
Sema4c 16
Sema4c 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEMA4C 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEMA4C 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sema4c 35
  • 84.83 (n)
  • 87.15 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 34 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia SEMA4C 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sema4c 35
  • 62.89 (n)
  • 60.34 (a)
zebrafish
(Danio rerio)
Actinopterygii sc:d411 35
  • 60.49 (n)
  • 57.55 (a)
SEMA4C 36
  • 54 (a)
OneToOne
sema4e 35
Species with no ortholog for SEMA4C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEMA4C Gene

ENSEMBL:
Gene Tree for SEMA4C (if available)
TreeFam:
Gene Tree for SEMA4C (if available)

Paralogs for SEMA4C Gene

genes like me logo Genes that share paralogs with SEMA4C: view

Variants for SEMA4C Gene

Sequence variations from dbSNP and Humsavar for SEMA4C Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2314649 -- 96,867,347(-) TTGCC(A/G)GGGCA intron-variant
rs6758045 -- 96,862,498(+) gcaaa(C/T)cactt intron-variant
rs6758174 -- 96,862,628(+) gaggc(C/T)gagtc intron-variant
rs7566053 -- 96,863,659(+) CAGTG(A/G)CAGAT intron-variant
rs7604991 -- 96,867,066(+) GCATG(C/T)AGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEMA4C Gene

Variant ID Type Subtype PubMed ID
dgv650e201 CNV Deletion 23290073
esv5003 CNV Complex 18987735
nsv874677 CNV Loss 21882294
nsv874680 CNV Loss 21882294
nsv526313 CNV Loss 19592680
dgv4249n71 CNV Loss 21882294

Relevant External Links for SEMA4C Gene

HapMap Linkage Disequilibrium report
SEMA4C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEMA4C Gene

Disorders for SEMA4C Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SEMA4C Gene including...

Search for SEMA4C Gene in MalaCards »
genes like me logo Genes that share disorders with SEMA4C: view

No data available for UniProtKB/Swiss-Prot for SEMA4C Gene

Publications for SEMA4C Gene

  1. Identification of a member of mouse semaphorin family. (PMID: 7656991) Inagaki S. … Iwahashi Y. (FEBS Lett. 1995) 2 3
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Sema4C participates in myogenic differentiation in vivo and in vitro through the p38 MAPK pathway. (PMID: 17498836) Wu H. … Fan M. (Eur. J. Cell Biol. 2007) 3 4

Products for SEMA4C Gene

Sources for SEMA4C Gene

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