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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEMA4C Gene

protein-coding   GIFtS: 54
GCID: GC02M097525

Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain...


(Previous symbol: SEMAI)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And
Short Cytoplasmic Domain, (Semaphorin) 4C1 2
     SEMACL12
SEMAI1 2 3     SEMAF2
M-Sema F1 2     semaphorin-4C2
M-SEMA-F2     KIAA17393

External Ids:    HGNC: 107311   Entrez Gene: 549102   Ensembl: ENSG000001687587   OMIM: 6044625   UniProtKB: Q9C0C43   

Export aliases for SEMA4C gene to outside databases

Previous GC identifers: GC02M095302 GC02M095979 GC02M096993 GC02M097010 GC02M096947 GC02M096889 GC02M091485


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SEMA4C Gene: 
SEMA4C (sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C) is a protein-coding gene. Diseases associated with SEMA4C include cri-du-chat syndrome, and night blindness. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA3C.

UniProtKB/Swiss-Prot: SEM4C_HUMAN, Q9C0C4
Function: Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding
promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain
development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role
in myogenic differentiation through activation of the stress-activated MAPK cascade

Gene Wiki entry for SEMA4C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022171.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEMA4C gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   AhR   STAT5B   oct-B3   oct-B2   POU2F2   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEMA4C promoter sequence
   Search SABiosciences Chromatin IP Primers for SEMA4C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA4C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.2

SEMA4C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA4C gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M097525:  view genomic region     (about GC identifiers)

Start:
97,525,453 bp from pter      End:
97,536,494 bp from pter
Size:
11,042 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SEM4C_HUMAN, Q9C0C4 (See protein sequence)
Recommended Name: Semaphorin-4C precursor  
Size: 833 amino acids; 92623 Da
Subunit: Interacts (via the PDZ-binding motif) with GIPC (via the PDZ domain) (By similarity). Interacts with NCDN
(By similarity). Interacts (via the PDZ-binding motif) with DLG4. Interacts with PLXNB2 (By similarity)
Subcellular location: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density; Single-pass type I
membrane protein (By similarity). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass
type I membrane protein (By similarity)
Secondary accessions: Q32MJ3 Q7Z5X0

Explore the universe of human proteins at neXtProt for SEMA4C: NX_Q9C0C4

Explore proteomics data for SEMA4C at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9C0C4

  • SEMA4C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SEMA4C Protein Expression
    REFSEQ proteins: NP_060259.4  
    ENSEMBL proteins: 
     ENSP00000306844   ENSP00000393498   ENSP00000391094  

    Human Recombinant Protein Products for SEMA4C: 
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    Novus Biologicals SEMA4C Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEMA4C 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0014069postsynaptic density ISS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--
    GO:0030054cell junction IEA--

    SEMA4C for ontologies           About GeneDecksing



    SEMA4C Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    SEMA: Semaphorins

    5/9 InterPro protein domains (see all 9):
     IPR007110 Ig-like_dom
     IPR003659 Plexin-like
     IPR003599 Ig_sub
     IPR002165 Plexin_repeat
     IPR016201 Plexin-like_fold

    Graphical View of Domain Structure for InterPro Entry Q9C0C4

    ProtoNet protein and cluster: Q9C0C4

    2 Blocks protein domains:
    IPB001627 Semaphorin/CD100 antigen
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: SEM4C_HUMAN, Q9C0C4
    Similarity: Belongs to the semaphorin family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 PSI domain
    Similarity: Contains 1 Sema domain


    SEMA4C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEM4C_HUMAN, Q9C0C4
    Function: Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding
    promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain
    development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role
    in myogenic differentiation through activation of the stress-activated MAPK cascade

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----
         
    SEMA4C for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sema4c):
     cellular  integument  mortality/aging  nervous system  pigmentation 

    SEMA4C for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SEMA4C 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SEMA4C

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEMA4C 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEMA4C 

    miRNA
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    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA4C (see all 51):
    hsa-miR-136 hsa-let-7d hsa-miR-449a hsa-miR-570 hsa-let-7g hsa-let-7a hsa-miR-28-5p hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidSEMA4C 3' UTR sequence
    Inhib. RNA
    Products:
        
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                         Customized lentivirus expression plasmids for stable overexpression of SEMA4C 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA4C


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SEMA4C About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Axon guidance

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for SEMA4C):
        Axon guidance


    SEMA4C for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SEMA4C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/12 Interacting proteins for SEMA4C (Q9C0C43 ENSP000003068444) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG3Q927963, ENSP000003634804I2D: score=2 STRING: ENSP00000363480
    DLG1Q129593, ENSP000003457314I2D: score=1 STRING: ENSP00000345731
    NCDNQ9UBB63, ENSP000003483944I2D: score=1 STRING: ENSP00000348394
    GIPC1O149083, ENSP000003406984I2D: score=2 STRING: ENSP00000340698
    DLG2Q157003, ENSP000003652724I2D: score=2 STRING: ENSP00000365272
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001843neural tube closure ISS--
    GO:0007275multicellular organismal development ----
    GO:0021535cell migration in hindbrain ISS--
    GO:0021549cerebellum development IEA--
    GO:0032874positive regulation of stress-activated MAPK cascade IDA17498836

    SEMA4C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEMA4C (SEM4C)

    Search CenterWatch for drugs/clinical trials and news about SEMA4C / SEM4C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SEMA4C gene: 
    NM_017789.4  

    Unigene Cluster for SEMA4C:

    Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
    Hs.516220  [show with all ESTs]
    Unigene Representative Sequence: NM_017789
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305476(uc002sxh.4) ENST00000474420 ENST00000482925(uc002sxg.4)
    ENST00000467747(uc002sxf.4 uc002sxe.3) ENST00000442264 ENST00000449330

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA4C
    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA4C (see all 51):
    hsa-miR-136 hsa-let-7d hsa-miR-449a hsa-miR-570 hsa-let-7g hsa-let-7a hsa-miR-28-5p hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidSEMA4C 3' UTR sequence
    Inhib. RNA
    Products:
         
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    GenScript: all cDNA clones in your preferred vector: SEMA4C (NM_017789)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA4C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA4C
    Sirion Biotech Customized lentivirus for stable overexpression of SEMA4C 
                         Customized lentivirus expression plasmids for stable overexpression of SEMA4C 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA4C

    Additional mRNA sequence: 

    AF258577.1 AK000376.1 AY358842.1 BC017476.1 BC062984.1 BC109103.1 BC109104.1 

    10 DOTS entries:

    DT.442761  DT.101982662  DT.87004199  DT.120945726  DT.91739074  DT.97803902  DT.95231985  DT.100829757 
    DT.40131323  DT.97766009 

    24/124 AceView cDNA sequences (see all 124):

    AI864089 BF109101 BE302196 T51972 BQ926654 AB051526 CB851802 BC062984 
    BQ651466 BM971936 BQ068313 AK000376 BC017476 BQ932835 AA991513 CD518993 
    AW468222 AF370374 BU856924 AI926069 AK075388 BM685235 AY358842 BU855862 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SEMA4C (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18
    SP1:              -           -                                                                             -                 -                     
    SP2:                                                                                                        -                 -                     
    SP3:                          -                                                                                                                     
    SP4:        -     -           -                                                                                                                     
    SP5:                                                                                                                          -                     


    ECgene alternative splicing isoforms for SEMA4C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEMA4C expression in normal human tissues (normalized intensities)      SEMA4C embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTTGTGTG
    SEMA4C Expression
    About this image


    SEMA4C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Umbilical Cord (Extraembryonic Tissues)
             stem cells (umbilical cord cd34+)   
     
     Blood (Extraembryonic Tissues)
             stem cells (umbilical cord cd34+)   
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Brain (Nervous System)
             superior temporal gyrus   

     -- (Nervous System)
             trigeminal ganglia   

    See SEMA4C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEMA4C

    SOURCE GeneReport for Unigene cluster: Hs.516220
        SABiosciences Custom PCR Arrays for SEMA4C
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA4C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA4C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SEMA4C gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sema4c1 , 5 sema domain, immunoglobulin domain (Ig), transmembrane more1, 5 85.35(n)1
    87.88(a)1
      1 (15.32 cM)5
    203531  NM_001126047.11  NP_001119519.11 
     365486425 
    lizard
    (Anolis carolinensis)
    Reptilia SEMA4C6
    sema domain, immunoglobulin domain (Ig), transmemb...
    54(a)
    1 ↔ 1
    GL343484.1(347223-451297)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL860809.22   -- 74.03(n)    AL860809.2 
    zebrafish
    (Danio rerio)
    Actinopterygii sema4e2 semaphorin 4e 78.31(n)   30251  AF073289.1 


    ENSEMBL Gene Tree for SEMA4C (if available)
    TreeFam Gene Tree for SEMA4C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEMA4C gene
    SEMA3C2  SEMA4F2  SEMA3E2  SEMA4B2  SEMA3F2  SEMA4A2  SEMA4D2  SEMA4G2  
    SEMA3A2  SEMA3G2  SEMA3D2  
    18 SIMAP similar genes for SEMA4C using alignment to 5 protein entries:     SEM4C_HUMAN (see all proteins):
    SEMA4A    SEMA4G    SEMA4D variant protein    SEMA4D    SEMA3B    DKFZp686D04248
    SEMA3C    SEMA6D    SEMA4F    SEMA3E    SEMA4B    SEMA3A
    SEMA3F    PLXNC1    SEMA5A    SEMA3D    SEMA5B    DKFZp686A04130

    SEMA4C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/284 SNPs in SEMA4C are shown (see all 284)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1862819841,2
    --97525812(+) CCACCA/CCAAGC 1 -- ut310--------
    rs1161071731,2
    C--97525962(+) AGGAGG/AACCCA 1 -- ut311Minor allele frequency- A:0.01WA 118
    rs1159474041,2
    F--97526025(+) CGCGTG/ACACAC 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs3717117851,2
    C--97526037(+) CACAT-/AC/CA 
            
    ACACA
    2 -- ut310--------
    rs1387957261,2
    C--97526065(+) CAAAT-/ACAG  
            
    ACAAA
    1 -- ut310--------
    rs2020612831,2
    C,F--97526354(+) GGTGGG/AGGTTC 1 -- ut311Minor allele frequency- A:0.00EU 591
    rs2001623491,2
    C,F--97526357(+) GGGGGT/ATCCCC 1 -- ut311Minor allele frequency- A:0.00EU 575
    rs1996222891,2
    --97526359(+) GGGTTC/TCCCTC 1 -- ut310--------
    rs1887509061,2
    C--97526438(+) TCCGCA/GAGCTC 2 L syn10--------
    rs2012907891,2
    C--97526521(+) GTTCCA/GCCCAC 2 R W mis10--------

    HapMap Linkage Disequilibrium report for SEMA4C (97525453 - 97536494 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SEMA4C:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv650e201CNV Deletion23290073
    dgv4249n71CNV Loss21882294
    nsv874680CNV Loss21882294
    nsv526313CNV Loss19592680
    nsv874677CNV Loss21882294
    esv5003CNV Complex18987735


    Human Gene Mutation Database (HGMD): SEMA4C
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SEMA4C
    DNA2.0 Custom Variant and Variant Library Synthesis for SEMA4C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604462    OMIM disorders: --

    3 diseases for SEMA4C:    About MalaCards
    cri-du-chat syndrome    night blindness    blindness


    SEMA4C for disorders           About GeneDecksing


    Export disorders for SEMA4C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEMA4C gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with SEMA4C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sema4C participates in myogenic differentiation in vivo and in vitro through the p38 MAPK pathway. (PubMed id 17498836)1, 2 Wu H.... Fan M. (2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (2000)
    5. Identification of a member of mouse semaphorin family. (PubMed id 7656991)1, 3 Inagaki S....Iwahashi Y. (1995)
    6. [Expression and clinical significance of Sema4C in eso phageal cancer, gastric cancer and rectal cancer]. (PubMed id 22944267)1 Ye S.M....Wang S.X. (2012)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Role of Sema4C in TGF-I^1-induced mitogen-activated pr otein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells. (PubMed id 20959347)1 Zeng R....Xu G. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54910 HGNC: 10731 AceView: SEMA4C Ensembl:ENSG00000168758 euGenes: HUgn54910
    ECgene: SEMA4C Kegg: 54910 H-InvDB: SEMA4C

    (According to HUGE)
    About This Section
    HUGE: KIAA1739

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEMA4C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEMA4C gene:
    Search GeneIP for patents involving SEMA4C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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