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Aliases for SEMA4B Gene

Aliases for SEMA4B Gene

  • Semaphorin 4B 2 3
  • Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4B 2 3 5
  • SEMAC 3 4
  • Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, 4B 3
  • KIAA1745 4
  • SemC 3

External Ids for SEMA4B Gene

Previous HGNC Symbols for SEMA4B Gene

  • SEMAC

Previous GeneCards Identifiers for SEMA4B Gene

  • GC15M087399
  • GC15P084251
  • GC15P088331
  • GC15P088474
  • GC15P088457
  • GC15P088529
  • GC15P090728
  • GC15P066843
  • GC15P090703

Summaries for SEMA4B Gene

GeneCards Summary for SEMA4B Gene

SEMA4B (Semaphorin 4B) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA3F.

UniProtKB/Swiss-Prot for SEMA4B Gene

  • Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.

Gene Wiki entry for SEMA4B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMA4B Gene

Genomics for SEMA4B Gene

Regulatory Elements for SEMA4B Gene

Genomic Location for SEMA4B Gene

Chromosome:
15
Start:
90,160,604 bp from pter
End:
90,229,679 bp from pter
Size:
69,076 bases
Orientation:
Plus strand

Genomic View for SEMA4B Gene

Genes around SEMA4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEMA4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEMA4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA4B Gene

Proteins for SEMA4B Gene

  • Protein details for SEMA4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPR2-SEM4B_HUMAN
    Recommended name:
    Semaphorin-4B
    Protein Accession:
    Q9NPR2
    Secondary Accessions:
    • Q6UXE3
    • Q8WVP9
    • Q96FK5
    • Q9C0B8
    • Q9H691
    • Q9NPM8
    • Q9NPN0

    Protein attributes for SEMA4B Gene

    Size:
    832 amino acids
    Molecular mass:
    92193 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ88758.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAR15707.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB15372.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB21836.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SEMA4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEMA4B Gene

Proteomics data for SEMA4B Gene at MOPED

Post-translational modifications for SEMA4B Gene

  • Glycosylation at Asn 64, Asn 91, Asn 160, Asn 405, Asn 520, and Asn 625
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for SEMA4B (Semaphorin 4B)
  • Cell Signaling Technology (CST) Antibodies for SEMA4B (SEMA4B)

No data available for DME Specific Peptides for SEMA4B Gene

Domains & Families for SEMA4B Gene

Gene Families for SEMA4B Gene

Graphical View of Domain Structure for InterPro Entry

Q9NPR2

UniProtKB/Swiss-Prot:

SEM4B_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Belongs to the semaphorin family.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 PSI domain.
  • Contains 1 Sema domain.
Family:
  • Belongs to the semaphorin family.
genes like me logo Genes that share domains with SEMA4B: view

Function for SEMA4B Gene

Molecular function for SEMA4B Gene

UniProtKB/Swiss-Prot Function:
Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
genes like me logo Genes that share phenotypes with SEMA4B: view

Animal Models for SEMA4B Gene

MGI Knock Outs for SEMA4B:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SEMA4B Gene

Localization for SEMA4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA4B Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEMA4B Gene COMPARTMENTS Subcellular localization image for SEMA4B gene
Compartment Confidence
plasma membrane 5
extracellular 4
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SEMA4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with SEMA4B: view

Pathways & Interactions for SEMA4B Gene

genes like me logo Genes that share pathways with SEMA4B: view

Pathways by source for SEMA4B Gene

Gene Ontology (GO) - Biological Process for SEMA4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030335 positive regulation of cell migration IBA --
genes like me logo Genes that share ontologies with SEMA4B: view

No data available for SIGNOR curated interactions for SEMA4B Gene

Drugs & Compounds for SEMA4B Gene

No Compound Related Data Available

Transcripts for SEMA4B Gene

Unigene Clusters for SEMA4B Gene

Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA4B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -

Relevant External Links for SEMA4B Gene

GeneLoc Exon Structure for
SEMA4B
ECgene alternative splicing isoforms for
SEMA4B

Expression for SEMA4B Gene

mRNA expression in normal human tissues for SEMA4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEMA4B Gene

This gene is overexpressed in Esophagus - Mucosa (x4.2).

Protein differential expression in normal tissues from HIPED for SEMA4B Gene

This gene is overexpressed in Serum (38.4) and Cervix (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SEMA4B Gene



SOURCE GeneReport for Unigene cluster for SEMA4B Gene Hs.474935

genes like me logo Genes that share expression patterns with SEMA4B: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SEMA4B Gene

Orthologs for SEMA4B Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEMA4B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SEMA4B 35
  • 84.72 (n)
  • 81.94 (a)
SEMA4B 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEMA4B 35
  • 86.81 (n)
  • 87.48 (a)
SEMA4B 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sema4b 35
  • 83.19 (n)
  • 85.53 (a)
Sema4b 16
Sema4b 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SEMA4B 35
  • 96.77 (n)
  • 95.56 (a)
SEMA4B 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sema4b 35
  • 82.98 (n)
  • 86.13 (a)
oppossum
(Monodelphis domestica)
Mammalia SEMA4B 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEMA4B 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEMA4B 35
  • 70.14 (n)
  • 63.45 (a)
SEMA4B 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sema4b 35
  • 60.94 (n)
  • 59.41 (a)
zebrafish
(Danio rerio)
Actinopterygii SEMA4B (2 of 2) 36
  • 47 (a)
OneToMany
sema4ba 36
  • 50 (a)
OneToMany
Species with no ortholog for SEMA4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEMA4B Gene

ENSEMBL:
Gene Tree for SEMA4B (if available)
TreeFam:
Gene Tree for SEMA4B (if available)

Paralogs for SEMA4B Gene

genes like me logo Genes that share paralogs with SEMA4B: view

Variants for SEMA4B Gene

Sequence variations from dbSNP and Humsavar for SEMA4B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_010758 -
rs7024 -- 90,229,599(-) AAAAT(A/G)TATAA utr-variant-3-prime
rs1107460 -- 90,224,628(+) TGGGA(C/T)GCTCT intron-variant
rs1107461 -- 90,224,643(+) GGCCA(C/G)GGCTT intron-variant
rs1113197 -- 90,219,079(+) TAGAG(A/T)AGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEMA4B Gene

Variant ID Type Subtype PubMed ID
dgv776e1 CNV Complex 17122850
dgv112e55 CNV Gain 17911159
dgv777e1 CNV Complex 17122850
nsv442384 CNV CNV 18776908
nsv817707 CNV Gain 17921354
nsv904487 CNV Loss 21882294
nsv904488 CNV Gain 21882294
nsv904489 CNV Loss 21882294
dgv2435n71 CNV Loss 21882294
nsv904491 CNV Loss 21882294
nsv833087 CNV Loss 17160897

Variation tolerance for SEMA4B Gene

Residual Variation Intolerance Score: 47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.07; 80.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEMA4B Gene

HapMap Linkage Disequilibrium report
SEMA4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEMA4B Gene

Disorders for SEMA4B Gene

Relevant External Links for SEMA4B

Genetic Association Database (GAD)
SEMA4B
Human Genome Epidemiology (HuGE) Navigator
SEMA4B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEMA4B

No disorders were found for SEMA4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEMA4B Gene

Publications for SEMA4B Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48 67
  2. CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells. (PMID: 17213806) Nagai H. … Osada H. (Oncogene 2007) 3 23
  3. Semaphorin 4B interacts with the post-synaptic density protein PSD-95/SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif. (PMID: 15978582) Burkhardt C. … PA1schel A.W. (FEBS Lett. 2005) 3 23
  4. Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. (PMID: 7748561) PA1schel A.W. … Betz H. (Neuron 1995) 2 3
  5. Hypoxia and hypoxia-inducible factor 1 repress SEMA4B expression to promote non-small cell lung cancer invasion. (PMID: 24474252) Jian H. … Zhang J. (Tumour Biol. 2014) 3

Products for SEMA4B Gene

Sources for SEMA4B Gene

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