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Aliases for SEMA4B Gene

Aliases for SEMA4B Gene

  • Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4B 2 3
  • SEMAC 3 4
  • Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, 4B 3
  • Semaphorin-4B 3
  • KIAA1745 4
  • SemC 3

External Ids for SEMA4B Gene

Previous HGNC Symbols for SEMA4B Gene

  • SEMAC

Previous GeneCards Identifiers for SEMA4B Gene

  • GC15M087399
  • GC15P084251
  • GC15P088331
  • GC15P088474
  • GC15P088457
  • GC15P088529
  • GC15P090728
  • GC15P066843
  • GC15P090703

Summaries for SEMA4B Gene

GeneCards Summary for SEMA4B Gene

SEMA4B (Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4B) is a Protein Coding gene. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA4G.

UniProtKB/Swiss-Prot for SEMA4B Gene

  • Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.

Gene Wiki entry for SEMA4B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMA4B Gene

Genomics for SEMA4B Gene

Regulatory Elements for SEMA4B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SEMA4B Gene

Start:
90,160,604 bp from pter
End:
90,229,679 bp from pter
Size:
69,076 bases
Orientation:
Plus strand

Genomic View for SEMA4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEMA4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA4B Gene

Proteins for SEMA4B Gene

  • Protein details for SEMA4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPR2-SEM4B_HUMAN
    Recommended name:
    Semaphorin-4B
    Protein Accession:
    Q9NPR2
    Secondary Accessions:
    • Q6UXE3
    • Q8WVP9
    • Q96FK5
    • Q9C0B8
    • Q9H691
    • Q9NPM8
    • Q9NPN0

    Protein attributes for SEMA4B Gene

    Size:
    832 amino acids
    Molecular mass:
    92193 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ88758.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAR15707.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB15372.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB21836.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SEMA4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEMA4B Gene

Proteomics data for SEMA4B Gene at MOPED

Post-translational modifications for SEMA4B Gene

  • Glycosylation at Asn64, Asn91, Asn160, Asn405, Asn520, and Asn625
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for SEMA4B (Semaphorin 4B)
  • Cell Signaling Technology (CST) Antibodies for SEMA4B (SEMA4B iso3)

No data available for DME Specific Peptides for SEMA4B Gene

Domains for SEMA4B Gene

Gene Families for SEMA4B Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

Q9NPR2

UniProtKB/Swiss-Prot:

SEM4B_HUMAN :
  • Q9NPR2
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 PSI domain.
  • Contains 1 Sema domain.
Family:
  • Belongs to the semaphorin family.
genes like me logo Genes that share domains with SEMA4B: view

Function for SEMA4B Gene

Molecular function for SEMA4B Gene

UniProtKB/Swiss-Prot Function: Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.

Gene Ontology (GO) - Molecular Function for SEMA4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SEMA4B: view

Phenotypes for SEMA4B Gene

genes like me logo Genes that share phenotypes with SEMA4B: view

Animal Models for SEMA4B Gene

MGI Knock Outs for SEMA4B:

Animal Model Products

CRISPR Products

miRNA for SEMA4B Gene

miRTarBase miRNAs that target SEMA4B

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEMA4B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SEMA4B Gene

Localization for SEMA4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA4B Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEMA4B Gene COMPARTMENTS Subcellular localization image for SEMA4B gene
Compartment Confidence
plasma membrane 3
extracellular 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SEMA4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0045202 synapse --
genes like me logo Genes that share ontologies with SEMA4B: view

Pathways for SEMA4B Gene

genes like me logo Genes that share pathways with SEMA4B: view

Pathways by source for SEMA4B Gene

2 Cell Signaling Technology pathways for SEMA4B Gene
1 KEGG pathway for SEMA4B Gene

Gene Ontology (GO) - Biological Process for SEMA4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development --
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SEMA4B: view

Transcripts for SEMA4B Gene

Unigene Clusters for SEMA4B Gene

Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEMA4B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SEMA4B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA4B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -

Relevant External Links for SEMA4B Gene

GeneLoc Exon Structure for
SEMA4B
ECgene alternative splicing isoforms for
SEMA4B

Expression for SEMA4B Gene

mRNA expression in normal human tissues for SEMA4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEMA4B Gene

This gene is overexpressed in Esophagus - Mucosa (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SEMA4B Gene

SOURCE GeneReport for Unigene cluster for SEMA4B Gene Hs.474935

genes like me logo Genes that share expressions with SEMA4B: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SEMA4B Gene

Orthologs for SEMA4B Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEMA4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEMA4B 35
  • 96.77 (n)
  • 95.56 (a)
SEMA4B 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SEMA4B 35
  • 84.72 (n)
  • 81.94 (a)
SEMA4B 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEMA4B 35
  • 86.81 (n)
  • 87.48 (a)
SEMA4B 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sema4b 35
  • 83.19 (n)
  • 85.53 (a)
Sema4b 16
Sema4b 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEMA4B 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEMA4B 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sema4b 35
  • 82.98 (n)
  • 86.13 (a)
chicken
(Gallus gallus)
Aves SEMA4B 35
  • 70.14 (n)
  • 63.45 (a)
SEMA4B 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sema4b 35
  • 60.94 (n)
  • 59.41 (a)
zebrafish
(Danio rerio)
Actinopterygii SEMA4B (2 of 2) 36
  • 47 (a)
OneToMany
sema4ba 36
  • 50 (a)
OneToMany
Species with no ortholog for SEMA4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEMA4B Gene

ENSEMBL:
Gene Tree for SEMA4B (if available)
TreeFam:
Gene Tree for SEMA4B (if available)

Paralogs for SEMA4B Gene

genes like me logo Genes that share paralogs with SEMA4B: view

Variants for SEMA4B Gene

Sequence variations from dbSNP and Humsavar for SEMA4B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs7024 -- 90,229,599(-) AAAAT(A/G)TATAA utr-variant-3-prime
rs868285 -- 90,193,289(-) CCACA(C/G)GAGGA intron-variant
rs883408 -- 90,192,544(+) GCTTT(A/T)TACTT intron-variant
rs908044 -- 90,225,727(-) GCTCC(G/T)GTACA reference, synonymous-codon
rs908047 -- 90,223,369(+) TTAGT(C/T)ACAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEMA4B Gene

Variant ID Type Subtype PubMed ID
dgv776e1 CNV Complex 17122850
dgv112e55 CNV Gain 17911159
dgv777e1 CNV Complex 17122850
nsv442384 CNV CNV 18776908
nsv817707 CNV Gain 17921354
nsv904487 CNV Loss 21882294
nsv904488 CNV Gain 21882294
nsv904489 CNV Loss 21882294
dgv2435n71 CNV Loss 21882294
nsv904491 CNV Loss 21882294
nsv833087 CNV Loss 17160897

Relevant External Links for SEMA4B Gene

HapMap Linkage Disequilibrium report
SEMA4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEMA4B Gene

Disorders for SEMA4B Gene

Relevant External Links for SEMA4B

Genetic Association Database (GAD)
SEMA4B
Human Genome Epidemiology (HuGE) Navigator
SEMA4B
genes like me logo Genes that share disorders with SEMA4B: view

No data available for UniProtKB/Swiss-Prot for SEMA4B Gene

Publications for SEMA4B Gene

  1. Semaphorin 4B interacts with the post-synaptic density protein PSD-95/SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif. (PMID: 15978582) Burkhardt C. … PA1schel A.W. (FEBS Lett. 2005) 3 23
  2. CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells. (PMID: 17213806) Nagai H. … Osada H. (Oncogene 2007) 3 23
  3. Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. (PMID: 7748561) PA1schel A.W. … Betz H. (Neuron 1995) 2 3
  4. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4

Products for SEMA4B Gene

Sources for SEMA4B Gene

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