SEMA4B Gene

Aliases
for SEMA4B gene

Previous GC identifers: GC15M087399 GC15P084251 GC15P088331 GC15P088474 GC15P088457 GC15P088529 GC15P090728 GC15P066843

Summaries
for SEMA4B gene

Genomic Views
for SEMA4B gene

RefSeq DNA sequence:

NC_000015.9  NC_018926.1  NT_010274.17  

SwitchGear Promoter luciferase reporter plasmid: SEMA4B promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA4B

SEMA4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P090703:  view genomic region     (about GC identifiers)

Proteins
for SEMA4B gene

Explore the universe of human proteins at neXtProt for SEMA4B: NX_Q9NPR2

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): SEMA4B OriGene Protein Over-expression Lysate (see all 2): SEMA4B OriGene Custom Protein Services for SEMA4B
	GenScript Custom Purified and Recombinant Proteins Services for SEMA4B
	Novus Biologicals SEMA4B Protein Novus Biologicals SEMA4B Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SEMA4B

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for SEMA4B (Semaphorin 4B)
	Cell Signaling Technology (CST) Antibodies for SEMA4B
	Browse OriGene Antibodies OriGene Custom Antibody Services for SEMA4B
	GenScript Custom Superior Antibodies Services for SEMA4B
	Novus Biologicals SEMA4B Antibodies
	Abcam antibodies for SEMA4B
	Uscn Antibodies for SEMA4B
	Search ThermoFisher Antibodies for SEMA4B

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SEMA4B
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SEMA4B

Protein Domains /
Families
for SEMA4B gene

ProtoNet protein and cluster: Q9NPR2

Function
for SEMA4B gene

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Sema4b)

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SEMA4B

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SEMA4B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA4B
		8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA4B (see all 35):
		hsa-miR-188-5p hsa-miR-4328 hsa-miR-106a hsa-miR-519a hsa-miR-449a hsa-miR-93 hsa-miR-23a hsa-miR-4293
		SwitchGear 3'UTR luciferase reporter plasmid: SEMA4B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA4B (see all 4) OriGene shRNA RFP: SEMA4B OriGene siRNA: SEMA4B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA4B
		Sirion Biotech Custom design and validation of potent shRNA sequences against SEMA4B

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SEMA4B
			Sirion Biotech Customized adenovirus for overexpression of SEMA4B  Sirion Biotech Customized adenovirus for potent knockdown of SEMA4B

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA4B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA4B (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SEMA4B (NM_020210)
		Sino Biological Human cDNA Clone for SEMA4B
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA4B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA4B

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SEMA4B
		Search LifeMap BioReagents cell lines for SEMA4B
		Sirion Biotech Customized stable knockdown cell line services for SEMA4B  Sirion Biotech Customized inducible knockdown cell line services for SEMA4B Sirion Biotech Customized stable overexpressing cell line services for SEMA4B Sirion Biotech Customized inducible overexpressing cell line services for SEMA4B

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA4B

Pathways & Interactions
for SEMA4B gene

	Super-pathway	contained gene-specific pathways
1	Apoptotic Pathways in Synovial Fibroblasts	8/14 pathways (see all 14) Apoptotic Pathways in Synovial Fibroblasts 1.00 ERK5 Signaling 0.61 p53 Mediated Apoptosis 0.84 eIF2 Pathway 0.60 Mitochondrial Apoptosis 0.73 Rac1 Pathway 0.58 Telomerase Components in Cell Signaling 0.72 Nuclear Receptor Activation by Vitamin-A 0.57
2	GPCR Pathway	GPCR Pathway 1.00 Estrogen Pathway 0.55 Ras Pathway 0.62 Pancreatic Adenocarcinoma 0.55 Breast Cancer Regulation by Stathmin1 0.58 Paxillin Interactions 0.53 NFAT in Immune Response 0.58
3	Rho Family GTPases	Rho Family GTPases 1.00 MAPK Signaling 0.51 ERK Signaling 0.61 ILK Signaling 0.45 Molecular Mechanisms of Cancer 0.51
4	TGF-Beta Pathway	TGF-Beta Pathway 1.00 JAK-STAT Pathway 0.57 MAPK Family Pathway 0.60 JNK Pathway 0.50
5	Nanog in Mammalian ESC Pluripotency	Nanog in Mammalian ESC Pluripotency 1.00 14-3-3 Induced Intracellular Signaling 0.59 GSK3 Signaling 0.61 eNOS Signaling 0.48

5/54 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SEMA4B

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

2 Cell Signaling Technology (CST) Pathways for SEMA4B

	Neuroscience
	PI3K / Akt Signaling

1         Kegg Pathway  (Kegg details for SEMA4B)

Axon guidance

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for SEMA4B gene

Transcripts
for SEMA4B gene

Expression
for SEMA4B gene

SEMA4B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTCCCAGG

About this image

SEMA4B expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEMA4B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEMA4B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA4B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA4B

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA4B

Orthologs
for SEMA4B gene

Paralogs
for SEMA4B gene

Paralogs for SEMA4B gene

SEMA3C²  SEMA4F²  SEMA3E²  SEMA3F²  SEMA4C²  SEMA4A²  SEMA4G²  SEMA4D²  

SEMA3A²  SEMA3G²  SEMA3D²  

18/20 SIMAP similar genes for SEMA4B using alignment to 14 protein entries:     SEM4B_HUMAN (see all proteins) (see all similar genes):

DKFZp686A04130    SEMA4D    DKFZp686D04248    SEMA4A    SEMA3A    SEMA4D variant protein

SEMA5B    SEMA3F    SEMA4G    SEMA3E    SEMA3C    SEMA6D

SEMA4C    SEMA5A    PLXNC1    SEMA3B    SEMA3D    SEMA3G

SEMA4B for paralogs           About GeneDecksing

Genomic Variants
for SEMA4B gene

10/1019 NCBI SNPs in SEMA4B are shown (see all 1019)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1395361501,2		--	90726210(+)	AATGTG/TATAGA	1	--	us2k1		0	--	--	--	--
rs1834810891,2		--	90726336(+)	GAAACC/TCCGTC	1	--	us2k1		0	--	--	--	--
rs1872205301,2		--	90726338(+)	AACCCC/TGTCTC	1	--	us2k1		0	--	--	--	--
rs1496614861,2		--	90726424(+)	AGAATC/TGCTTG	1	--	us2k1		0	--	--	--	--
rs1466804951,2		--	90726451(+)	GTTACA/GGTGAG	1	--	us2k1		0	--	--	--	--
rs1414147271,2		--	90726505(+)	GACTCA/CATCTC	1	--	us2k1		0	--	--	--	--
rs727604351,2	C,F	--	90726542(+)	GAATGA/C/TTGTCC	1	--	us2k1		1		WA	118
rs1917385381,2		--	90726758(+)	TGGCTC/TACGCC	1	--	us2k1		0	--	--	--	--
rs116337511,2	H	--	90726786(+)	gggggC/Gccaag	1	--	us2k1		0	--	--	--	--
rs1839154061,2		--	90726795(+)	AGGCGA/GGTGGG	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for SEMA4B (90703836 - 90772911 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for SEMA4B
     7 CNVs: 77066 8803 3976 3094 77067 9752 37691

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEMA4B

DNA2.0 Custom Variant and Variant Library Synthesis for SEMA4B

Disorders / Diseases
for SEMA4B gene

Publications
for SEMA4B gene

PubMed articles for SEMA4B gene, integrated from 9 sources (see all 19): (articles sorted by number of sources associating them with SEMA4B)

Utopia: connect your pdf to the dynamic world of online information

1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
7. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)^{1, 2} Nagase T.... Ohara O. (2000)
8. Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. (PubMed id 7748561)^{1, 3} Puschel A.W....Betz H. (1995)
9. CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells. (PubMed id 17213806)^{1, 9} Nagai H....Osada H. (2007)
10. Semaphorin 4B interacts with the post-synaptic density protein PSD-95/SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif. (PubMed id 15978582)^{1, 9} Burkhardt C....Puschel A.W. (2005)

External Searches for SEMA4B gene

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Products
for SEMA4B gene