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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEMA4B Gene

protein-coding   GIFtS: 58
GCID: GC15P090703

Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain...


(Previous symbol: SEMAC)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And
Short Cytoplasmic Domain, (Semaphorin) 4B1 2
SEMAC1 2 3
SemC2
Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And
Short Cytoplasmic Domain, 4B2
semaphorin-4B2
KIAA17453

External Ids:    HGNC: 107301   Entrez Gene: 105092   Ensembl: ENSG000001850337   UniProtKB: Q9NPR23   

Export aliases for SEMA4B gene to outside databases

Previous GC identifers: GC15M087399 GC15P084251 GC15P088331 GC15P088474 GC15P088457 GC15P088529 GC15P090728 GC15P066843


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SEMA4B Gene: 
SEMA4B (sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B) is a protein-coding gene. Diseases associated with SEMA4B include klippel-trenaunay syndrome, and radiculopathy, and among its related super-pathways are Rac1 Pathway and Ras Pathway. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA3C.

UniProtKB/Swiss-Prot: SEM4B_HUMAN, Q9NPR2
Function: Inhibits axonal extension by providing local signals to specify territories inaccessible for growing
axons (By similarity)

Gene Wiki entry for SEMA4B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010274.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEMA4B gene promoter:
         HEN1   Max1   Spz1   Pax-4a   GATA-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEMA4B promoter sequence
   Search SABiosciences Chromatin IP Primers for SEMA4B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q25

SEMA4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA4B gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P090703:  view genomic region     (about GC identifiers)

Start:
90,703,836 bp from pter      End:
90,772,911 bp from pter
Size:
69,076 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SEM4B_HUMAN, Q9NPR2 (See protein sequence)
Recommended Name: Semaphorin-4B precursor  
Size: 832 amino acids; 92193 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Sequence caution: Sequence=AAQ88758.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAR15707.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB15372.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB21836.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q6UXE3 Q8WVP9 Q96FK5 Q9C0B8 Q9H691 Q9NPM8 Q9NPN0
Alternative splicing: 2 isoforms:  Q9NPR2-1   Q9NPR2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEMA4B: NX_Q9NPR2

Explore proteomics data for SEMA4B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NPR2

  • SEMA4B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SEMA4B Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_064595.2  NP_945119.1  

    ENSEMBL proteins: 
     ENSP00000453272   ENSP00000452957   ENSP00000453951   ENSP00000332204   ENSP00000453705  
     ENSP00000453563   ENSP00000394720   ENSP00000453484   ENSP00000452886   ENSP00000453804  
     ENSP00000453866   ENSP00000454068   ENSP00000368417  

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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEMA4B 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    SEMA4B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SEMA: Semaphorins

    5/6 InterPro protein domains (see all 6):
     IPR003659 Plexin-like
     IPR002165 Plexin_repeat
     IPR016201 Plexin-like_fold
     IPR027231 Semaphorin
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9NPR2

    ProtoNet protein and cluster: Q9NPR2

    1 Blocks protein domain: IPB001627 Semaphorin/CD100 antigen

    UniProtKB/Swiss-Prot: SEM4B_HUMAN, Q9NPR2
    Similarity: Belongs to the semaphorin family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 PSI domain
    Similarity: Contains 1 Sema domain


    SEMA4B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEM4B_HUMAN, Q9NPR2
    Function: Inhibits axonal extension by providing local signals to specify territories inaccessible for growing
    axons (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----
         
    SEMA4B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SEMA4B:
     Decreased Hepatitis C virus re 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sema4b):
     immune system  nervous system 

    SEMA4B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sema4btm1Akum for SEMA4B

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SEMA4B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SEMA4B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEMA4B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEMA4B 

    miRNA
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    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA4B (see all 35):
    hsa-miR-188-5p hsa-miR-4328 hsa-miR-106a hsa-miR-519a hsa-miR-449a hsa-miR-93 hsa-miR-23a hsa-miR-4293
    SwitchGear 3'UTR luciferase reporter plasmidSEMA4B 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA4B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SEMA4B About   (see all 15)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    3Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/54 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SEMA4B (see all 54)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for SEMA4B
        Neuroscience
    PI3K / Akt Signaling



    1         Kegg Pathway  (Kegg details for SEMA4B):
        Axon guidance


    SEMA4B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEMA4B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/9 Interacting proteins for SEMA4B (Q9NPR23 ENSP000003322044) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GIPC1O149083, ENSP000003406984I2D: score=2 STRING: ENSP00000340698
    DLG4P783523I2D: score=1 
    GIPC2Q8TF653I2D: score=1 
    PLXNB2ENSP000003522884STRING: ENSP00000352288
    PLXNB3ENSP000003553784STRING: ENSP00000355378
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development ----
    GO:0007399nervous system development IEA--
    GO:0030154cell differentiation IEA--

    SEMA4B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEMA4B (SEM4B)

    Search CenterWatch for drugs/clinical trials and news about SEMA4B / SEM4B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SEMA4B gene (2 alternative transcripts): 
    NM_020210.3  NM_198925.2  

    Unigene Cluster for SEMA4B:

    Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
    Hs.474935  [show with all ESTs]
    Unigene Representative Sequence: NM_020210
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000559322 ENST00000559300 ENST00000561085 ENST00000332496(uc002boy.3)
    ENST00000558895 ENST00000560263 ENST00000559792 ENST00000411539(uc002boz.3 uc010uqd.2)
    ENST00000560089 ENST00000558051 ENST00000560003 ENST00000558848 ENST00000558065(uc002bpa.3)
    ENST00000558975 ENST00000559074 ENST00000560993 ENST00000561252 ENST00000559983

    miRNA
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    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA4B (see all 35):
    hsa-miR-188-5p hsa-miR-4328 hsa-miR-106a hsa-miR-519a hsa-miR-449a hsa-miR-93 hsa-miR-23a hsa-miR-4293
    SwitchGear 3'UTR luciferase reporter plasmidSEMA4B 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB051532.1 AF258561.1 AK026108.1 AK026133.1 AK027083.1 AK289991.1 AL390080.1 AL390081.1 
    AL390082.1 AY358392.1 AY445887.1 BC010701.1 BC017658.1 BC019013.2 BC094849.1 BC110853.1 
    BC126438.1 BC144141.1 BX537671.1 

    21 DOTS entries:

    DT.453192  DT.91763674  DT.99982783  DT.121053404  DT.121053425  DT.86845966  DT.95364186  DT.121053367 
    DT.121053406  DT.121053436  DT.91763678  DT.95259102  DT.95364189  DT.100766577  DT.121053388  DT.121053398 
    DT.91667056  DT.91677628  DT.91788245  DT.95358436  DT.95364185 

    24/348 AceView cDNA sequences (see all 348):

    AA634725 BQ216757 BM977614 CA950964 AL390080 AY358392 BG386070 AL390082 
    BG058575 AA827526 BF725666 AI583396 BG424478 BM693948 BG470201 AK026108 
    CR605527 BU542955 BU552547 AI276415 BF590292 NM_198925 AA994956 AW188080 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SEMA4B (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17
    SP1:                                -           -                                   -                                   -           -                           
    SP2:                                            -                                   -                                   -           -                           
    SP3:                                                                                -                                   -           -                 -         
    SP4:                                                                                                                    -                                       
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for SEMA4B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEMA4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTCCCAGG
    SEMA4B Expression
    About this image


    See SEMA4B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEMA4B

    SOURCE GeneReport for Unigene cluster: Hs.474935
        SABiosciences Custom PCR Arrays for SEMA4B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA4B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SEMA4B gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sema4b1 , 5 sema domain, immunoglobulin domain (Ig), transmembrane more1, 5 83.11(n)1
    85.17(a)1
      7 (45.51 cM)5
    203521  NM_013659.41  NP_038687.21 
     801868415 
    chicken
    (Gallus gallus)
    Aves SEMA4B1 sema domain, immunoglobulin domain (Ig), transmembrane more 69.36(n)
    62.24(a)
      415582  XM_413950.3  XP_413950.3 
    zebrafish
    (Danio rerio)
    Actinopterygii sema4ba1 sema domain, immunoglobulin domain (Ig), transmembrane more 58.1(n)
    53.62(a)
      572261  NM_001128352.1  NP_001121824.1 


    ENSEMBL Gene Tree for SEMA4B (if available)
    TreeFam Gene Tree for SEMA4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEMA4B gene
    SEMA3C2  SEMA4F2  SEMA3E2  SEMA4C2  SEMA3F2  SEMA4A2  SEMA4D2  SEMA4G2  
    SEMA3A2  SEMA3G2  SEMA3D2  
    18/20 SIMAP similar genes for SEMA4B using alignment to 14 protein entries:     SEM4B_HUMAN (see all proteins) (see all similar genes):
    DKFZp686A04130    SEMA4D    DKFZp686D04248    SEMA4A    SEMA3A    SEMA4D variant protein
    SEMA5B    SEMA3F    SEMA4G    SEMA3E    SEMA3C    SEMA6D
    SEMA4C    SEMA5A    PLXNC1    SEMA3B    SEMA3D    SEMA3G

    SEMA4B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1236 SNPs in SEMA4B are shown (see all 1236)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0107584
    ----see VAR_0107582 S A mis40--------
    rs1395361501,2
    --90726210(+) AATGTG/TATAGA 1 -- us2k10--------
    rs1834810891,2
    --90726336(+) GAAACC/TCCGTC 1 -- us2k10--------
    rs1872205301,2
    --90726338(+) AACCCC/TGTCTC 1 -- us2k10--------
    rs1496614861,2
    C--90726424(+) AGAATC/TGCTTG 1 -- us2k10--------
    rs1466804951,2
    C--90726451(+) GTTACA/GGTGAG 1 -- us2k10--------
    rs1414147271,2
    --90726505(+) GACTCA/CATCTC 1 -- us2k10--------
    rs727604351,2
    C,F--90726542(+) GAATGA/C/TTGTCC 1 -- us2k11WA 118
    rs1917385381,2
    --90726758(+) TGGCTC/TACGCC 1 -- us2k10--------
    rs116337511,2
    H--90726786(+) gggggC/Gccaag 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SEMA4B (90703836 - 90772911 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for SEMA4B (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv904491CNV Loss21882294
    nsv833087CNV Loss17160897
    dgv2435n71CNV Loss21882294
    nsv904487CNV Loss21882294
    nsv904489CNV Loss21882294
    nsv904488CNV Gain21882294
    nsv817707CNV Gain17921354
    dgv112e55CNV Gain17911159
    nsv442384CNV CNV18776908
    dgv776e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    6 diseases for SEMA4B:    About MalaCards
    klippel-trenaunay syndrome    radiculopathy    lung cancer    adenocarcinoma
    pancreatitis    breast cancer


    SEMA4B for disorders           About GeneDecksing

    Genetic Association Database (GAD): SEMA4B
    Human Genome Epidemiology (HuGE) Navigator: SEMA4B (3 documents)

    Export disorders for SEMA4B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEMA4B gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with SEMA4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    8. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (2000)
    9. Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. (PubMed id 7748561)1, 3 Puschel A.W....Betz H. (1995)
    10. CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells. (PubMed id 17213806)1, 9 Nagai H....Osada H. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10509 HGNC: 10730 AceView: SEMA4B Ensembl:ENSG00000185033 euGenes: HUgn10509
    ECgene: SEMA4B Kegg: 10509 H-InvDB: SEMA4B

    (According to HUGE)
    About This Section
    HUGE: KIAA1745

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEMA4B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEMA4B gene:
    Search GeneIP for patents involving SEMA4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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