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SEMA4B Gene

protein-coding   GIFtS: 59
GCID: GC15P090703

Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain...


(Previous symbol: SEMAC)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And
Short Cytoplasmic Domain, (Semaphorin) 4B1 2
SEMAC1 2 3
SemC2
Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And
Short Cytoplasmic Domain, 4B2
semaphorin-4B2
KIAA17453

External Ids:    HGNC: 107301   Entrez Gene: 105092   Ensembl: ENSG000001850337   UniProtKB: Q9NPR23   

Export aliases for SEMA4B gene to outside databases

Previous GC identifers: GC15M087399 GC15P084251 GC15P088331 GC15P088474 GC15P088457 GC15P088529 GC15P090728 GC15P066843


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SEMA4B Gene:
SEMA4B (sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B) is a protein-coding gene. Diseases associated with SEMA4B include klippel-trenaunay syndrome, and radiculopathy. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA3C.

UniProtKB/Swiss-Prot: SEM4B_HUMAN, Q9NPR2
Function: Inhibits axonal extension by providing local signals to specify territories inaccessible for growing
axons (By similarity)

Gene Wiki entry for SEMA4B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEMA4B gene promoter:
         HEN1   Max1   Spz1   Pax-4a   GATA-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEMA4B promoter sequence
   Search Chromatin IP Primers for SEMA4B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEMA4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q25

SEMA4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA4B gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P090703:  view genomic region     (about GC identifiers)

Start:
90,703,836 bp from pter      End:
90,772,911 bp from pter
Size:
69,076 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SEM4B_HUMAN, Q9NPR2 (See protein sequence)
Recommended Name: Semaphorin-4B precursor  
Size: 832 amino acids; 92193 Da
Sequence caution: Sequence=AAQ88758.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAR15707.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB15372.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB21836.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q6UXE3 Q8WVP9 Q96FK5 Q9C0B8 Q9H691 Q9NPM8 Q9NPN0
Alternative splicing: 2 isoforms:  Q9NPR2-1   Q9NPR2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEMA4B: NX_Q9NPR2

Explore proteomics data for SEMA4B at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn64, Asn91, Asn160, Asn405, Asn520, Asn625
  • Modification sites at PhosphoSitePlus

  • See SEMA4B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_064595.2  NP_945119.1  

    ENSEMBL proteins: 
     ENSP00000453272   ENSP00000452957   ENSP00000453951   ENSP00000332204   ENSP00000453705  
     ENSP00000453563   ENSP00000394720   ENSP00000453484   ENSP00000452886   ENSP00000453804  
     ENSP00000453866   ENSP00000454068   ENSP00000368417  

    SEMA4B Human Recombinant Protein Products:

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    Novus Biologicals SEMA4B Protein
    Novus Biologicals SEMA4B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEMA4B

    SEMA4B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for SEMA4B (Semaphorin 4B)
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    Abcam antibodies for SEMA4B
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    SEMA4B Assay Products:

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    GenScript Custom Assay Services for SEMA4B
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    Cloud-Clone Corp. ELISAs for SEMA4B
    Cloud-Clone Corp. CLIAs for SEMA4B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SEMA: Semaphorins

    5 InterPro protein domains:
     IPR002165 Plexin_repeat
     IPR027231 Semaphorin
     IPR001627 Semap_dom
     IPR016201 Plexin-like_fold
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9NPR2

    ProtoNet protein and cluster: Q9NPR2

    1 Blocks protein domain: IPB001627 Semaphorin/CD100 antigen

    UniProtKB/Swiss-Prot: SEM4B_HUMAN, Q9NPR2
    Similarity: Belongs to the semaphorin family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 PSI domain
    Similarity: Contains 1 Sema domain


    SEMA4B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEM4B_HUMAN, Q9NPR2
    Function: Inhibits axonal extension by providing local signals to specify territories inaccessible for growing
    axons (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----
         
    SEMA4B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SEMA4B:
     Decreased Hepatitis C virus re 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sema4b):
     hematopoietic system  immune system  nervous system 

    SEMA4B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sema4btm1Akum for SEMA4B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEMA4B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEMA4B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEMA4B

    miRNA
    Products:
        
    miRTarBase miRNAs that target SEMA4B:
    hsa-let-7e-5p (MIRT051498), hsa-mir-335-5p (MIRT017490)

    Block miRNA regulation of human, mouse, rat SEMA4B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEMA4B (see all 35):
    hsa-miR-188-5p hsa-miR-4328 hsa-miR-106a hsa-miR-519a hsa-miR-449a hsa-miR-93 hsa-miR-23a hsa-miR-4293
    SwitchGear 3'UTR luciferase reporter plasmidSEMA4B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SEMA4B
    Predesigned siRNA for gene silencing in human, mouse, rat SEMA4B

    Gene Editing
    Products:
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    Clone
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    OriGene ORF clones in mouse, rat for SEMA4B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SEMA4B (NM_020210)
    Sino Biological Human cDNA Clone for SEMA4B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA4B

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SEMA4B
    Browse ESI BIO Cell Lines and PureStem Progenitors for SEMA4B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA4B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SEM4B_HUMAN, Q9NPR2: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    SEMA4B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SEMA4B About   (see all 15)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SEMA4B (see all 54)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for SEMA4B
        Neuroscience
    PI3K / Akt Signaling



    1 Kegg Pathway  (Kegg details for SEMA4B):
        Axon guidance


    SEMA4B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEMA4B
    Interactions:

        Search GeneGlobe Interaction Network for SEMA4B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for SEMA4B (Q9NPR23 ENSP000003322044) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GIPC2Q8TF653, ENSP000003597954I2D: score=1 STRING: ENSP00000359795
    GIPC1O149083, ENSP000003406984I2D: score=2 STRING: ENSP00000340698
    DLG4P783523I2D: score=1 
    PLXNB2ENSP000003522884STRING: ENSP00000352288
    PLXNB3ENSP000003553784STRING: ENSP00000355378
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development ----
    GO:0007399nervous system development IEA--
    GO:0030154cell differentiation IEA--

    SEMA4B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEMA4B (SEM4B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SEMA4B gene (2 alternative transcripts): 
    NM_020210.3  NM_198925.2  

    Unigene Cluster for SEMA4B:

    Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
    Hs.474935  [show with all ESTs]
    Unigene Representative Sequence: NM_020210
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000559322 ENST00000559300 ENST00000561085 ENST00000332496(uc002boy.3)
    ENST00000558895 ENST00000560263 ENST00000559792 ENST00000411539(uc002boz.3 uc010uqd.2)
    ENST00000560089 ENST00000558051 ENST00000560003 ENST00000558848 ENST00000558065(uc002bpa.3)
    ENST00000558975 ENST00000559074 ENST00000560993 ENST00000561252 ENST00000559983

    miRNA
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    Block miRNA regulation of human, mouse, rat SEMA4B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEMA4B (see all 35):
    hsa-miR-188-5p hsa-miR-4328 hsa-miR-106a hsa-miR-519a hsa-miR-449a hsa-miR-93 hsa-miR-23a hsa-miR-4293
    SwitchGear 3'UTR luciferase reporter plasmidSEMA4B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SEMA4B
    Predesigned siRNA for gene silencing in human, mouse, rat SEMA4B
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SEMA4B (NM_020210)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA4B
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEMA4B
      QuantiTect SYBR Green Assays in human, mouse, rat SEMA4B
      QuantiFast Probe-based Assays in human, mouse, rat SEMA4B

    Additional mRNA sequence: 

    AB051532.1 AF258561.1 AK026108.1 AK026133.1 AK027083.1 AK289991.1 AL390080.1 AL390081.1 
    AL390082.1 AY358392.1 AY445887.1 BC010701.1 BC017658.1 BC019013.2 BC094849.1 BC110853.1 
    BC126438.1 BC144141.1 BX537671.1 

    21 DOTS entries:

    DT.453192  DT.91763674  DT.99982783  DT.121053404  DT.121053425  DT.86845966  DT.95364186  DT.121053367 
    DT.121053406  DT.121053436  DT.91763678  DT.95259102  DT.95364189  DT.100766577  DT.121053388  DT.121053398 
    DT.91667056  DT.91677628  DT.91788245  DT.95358436  DT.95364185 

    Selected AceView cDNA sequences (see all 348):

    BM563293 AA994956 AI276415 BX331913 AA293300 BU541977 CR605527 BU540882 
    BG424478 BU543096 AK026133 AW188080 BQ961691 AA405790 AW058649 BM768988 
    AY358392 BQ224963 AI583396 BQ944697 AI985743 CD673203 CA950964 BQ218453 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SEMA4B (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17
    SP1:                                -           -                                   -                                   -           -                           
    SP2:                                            -                                   -                                   -           -                           
    SP3:                                                                                -                                   -           -                 -         
    SP4:                                                                                                                    -                                       
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for SEMA4B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SEMA4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTCCCAGG
    SEMA4B Expression
    About this image


    SEMA4B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Endothelium (Cardiovascular System)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Extraembryonic Mesoderm (Extraembryonic Tissues)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
    SEMA4B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEMA4B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.474935
        Custom PCR Arrays for SEMA4B
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat SEMA4B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA4B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SEMA4B gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sema4b1 , 5 sema domain, immunoglobulin domain (Ig), transmembrane more1, 5 83.19(n)1
    85.53(a)1
      7 (45.51 cM)5
    203521  NM_013659.41  NP_038687.21 
     801868415 
    chicken
    (Gallus gallus)
    Aves SEMA4B1 sema domain, immunoglobulin domain (Ig), transmembrane more 70.14(n)
    63.45(a)
      415582  XM_004943956.1  XP_004944013.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sema4b1 sema domain, immunoglobulin domain (Ig), transmembrane more 60.94(n)
    59.41(a)
      100489037  XM_002932239.2  XP_002932285.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sema4ba6
    SEMA4B (2 of 2)6
    sema domain, immunoglobulin domain (Ig), transmemb...
    sema domain, immunoglobulin domain (Ig), transmemb...
    50(a)
    47(a)
    1 ↔ many
    1 ↔ many
    18(25561623-25689293) ENSDARG00000074414
    7(31582648-31603677) ENSDARG00000076104


    ENSEMBL Gene Tree for SEMA4B (if available)
    TreeFam Gene Tree for SEMA4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SEMA4B gene
    SEMA3C2  SEMA4F2  SEMA3E2  SEMA4C2  SEMA3F2  SEMA4A2  SEMA4D2  SEMA4G2  
    SEMA3A2  SEMA3G2  SEMA3D2  
    Selected SIMAP similar genes for SEMA4B using alignment to 14 protein entries:     SEM4B_HUMAN (see all proteins) (see all similar genes):
    DKFZp686A04130    SEMA4D    DKFZp686D04248    SEMA4A    SEMA3A    SEMA4D variant protein
    SEMA5B    SEMA3F    SEMA4G    SEMA3E    SEMA3C    SEMA6D
    SEMA4C    SEMA5A    PLXNC1    SEMA3B    SEMA3D    SEMA3G

    SEMA4B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SEMA4B (see all 1236)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1395361501,2
    --90726210(+) AATGTG/TATAGA 1 -- us2k10--------
    rs1834810891,2
    --90726336(+) GAAACC/TCCGTC 1 -- us2k10--------
    rs1872205301,2
    --90726338(+) AACCCC/TGTCTC 1 -- us2k10--------
    rs1496614861,2
    C--90726424(+) AGAATC/TGCTTG 1 -- us2k10--------
    rs1466804951,2
    C--90726451(+) GTTACA/GGTGAG 1 -- us2k10--------
    rs1414147271,2
    --90726505(+) GACTCA/CATCTC 1 -- us2k10--------
    rs727604351,2
    C,F--90726542(+) GAATGA/C/TTGTCC 1 -- us2k11WA 118
    rs1917385381,2
    --90726758(+) TGGCTC/TACGCC 1 -- us2k10--------
    rs116337511,2
    H--90726786(+) gggggC/Gccaag 1 -- us2k10--------
    rs1839154061,2
    --90726795(+) AGGCGA/GGTGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SEMA4B (90703836 - 90772911 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SEMA4B (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv904491CNV Loss21882294
    nsv833087CNV Loss17160897
    dgv2435n71CNV Loss21882294
    nsv904487CNV Loss21882294
    nsv904489CNV Loss21882294
    nsv904488CNV Gain21882294
    nsv817707CNV Gain17921354
    dgv112e55CNV Gain17911159
    nsv442384CNV CNV18776908
    dgv776e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEMA4B
    DNA2.0 Custom Variant and Variant Library Synthesis for SEMA4B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    6 diseases for SEMA4B:    
    About MalaCards
    klippel-trenaunay syndrome    radiculopathy    lung cancer    adenocarcinoma
    pancreatitis    breast cancer


    SEMA4B for disorders           About GeneDecksing

    Genetic Association Database (GAD): SEMA4B
    Human Genome Epidemiology (HuGE) Navigator: SEMA4B (3 documents)

    Export disorders for SEMA4B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SEMA4B gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with SEMA4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    8. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    9. Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. (PubMed id 7748561)1, 3 PA1schel A.W....Betz H. (Neuron 1995)
    10. CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells. (PubMed id 17213806)1, 9 Nagai H....Osada H. (Oncogene 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10509 HGNC: 10730 AceView: SEMA4B Ensembl:ENSG00000185033 euGenes: HUgn10509
    ECgene: SEMA4B Kegg: 10509 H-InvDB: SEMA4B

    (According to HUGE)
    About This Section

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    HUGE: KIAA1745

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SEMA4B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SEMA4B gene:
    Search GeneIP for patents involving SEMA4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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