SEMA4A Gene
protein-coding GIFtS: 55
GCID: GC01P156119
|
|
sema domain, immunoglobulin domain (Ig), transmembrane domain...
(Previous symbol: SEMAB)
| |
Aliases
for SEMA4A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And ShortCytoplasmic Domain, (Semaphorin) 4A1 2 | | FLJ122871 | | SEMAB1 2 3 | | SemB1 | | CORD101 2 5 | | Semaphorin-4A1 | | SEMB2 3 5 | | Semaphorin-B3 | | Sema B2 3 | | Semaphorin-B3 | | RP352 5 | | |
Export aliases for SEMA4A gene to outside databasesPrevious GC identifers: GC00U990481 GC01P153341 GC01P152934 GC01P154386 GC01P127481 |
Summaries
for SEMA4A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SEMA4A:
This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved innumerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded proteinis a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a semadomain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediatedendothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associatedwith retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10(CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have beenidentified.(provided by RefSeq, Sep 2010)
UniProtKB/Swiss-Prot: SEM4A_HUMAN, Q9H3S1Function: Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cellsignaling. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, andthereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axongrowth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible forgrowing axons (By similarity)
Gene Wiki entry for SEMA4A
|
Genomic Views
for SEMA4A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SEMA4A gene promoter:
c-Fos Max1 AP-1 Pax-5 Lmo2 Arnt C/EBPalpha HEN1 c-Jun c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for SEMA4A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA4A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q22 Ensembl cytogenetic band: 1q22 HGNC cytogenetic band: 1q22SEMA4A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P156119: view genomic region
(about GC identifiers)
Start:
|
156,117,157 bp from pter |
End:
|
156,147,543 bp from pter |
Size:
|
30,387 bases |
Orientation:
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plus strand |
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Proteins
for SEMA4A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SEM4A_HUMAN, Q9H3S1 (See
protein sequence)Recommended Name: Semaphorin-4A precursor Size: 761 amino acids; 83574 Da
Subunit: Interacts with PLXNB1, PLXNB2, PLXNB3 and PLXND1. Probable ligand for TIMD2 (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity)
Secondary accessions: B2RDH8 Q5TCI5 Q8WUA9Explore the universe of human proteins at neXtProt for SEMA4A: NX_Q9H3S1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H3S1
SEMA4A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001180229.1 NP_001180230.1 NP_001180231.1 NP_071762.2
ENSEMBL proteins: ENSP00000401391 ENSP00000399230 ENSP00000347117 ENSP00000357268 ENSP00000357267 ENSP00000357266 ENSP00000392865 ENSP00000357265 ENSP00000357269 Reactome Protein details: Q9H3S1
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
SEMA4A for ontologies About GeneDecksing
SEMA4A Antibody Products:
Assay Products for SEMA4A: |
Protein
Domains /
Families
for SEMA4A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SEMA4A for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9H3S1ProtoNet protein and cluster: Q9H3S1 1 Blocks protein family: IPB001627 Semaphorin/CD100 antigen
UniProtKB/Swiss-Prot: SEM4A_HUMAN, Q9H3S1Similarity: Belongs to the semaphorin familySimilarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domainSimilarity: Contains 1 PSI domainSimilarity: Contains 1 Sema domain |
Function
for SEMA4A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SEM4A_HUMAN, Q9H3S1Function: Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cellsignaling. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, andthereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axongrowth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible forgrowing axons (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA4A (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA4A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): SEMA4A (NM_022367) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SEMA4A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA4A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA4A |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
IEA | -- |
SEMA4A for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Sema4atm1Kik for SEMA4A
6 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Sema4a):
SEMA4A for phenotypes About GeneDecksing
|
Pathways & Interactions
for SEMA4A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Axon guidance | | | 2 | Other semaphorin interactions | | | 3 | Axon guidance | | | 4 | Sema4D in semaphorin signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for SEMA4A
1 
Kegg Pathway (Kegg details for SEMA4A):
SEMA4A for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEMA4A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/6 Interacting proteins for SEMA4A (Q9H3S12, 3 ENSP000003471174) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table
SEMA4A for ontologies About GeneDecksing
|
Drugs & Compounds
for SEMA4A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SEMA4A
Search CenterWatch for drugs/clinical trials and news about SEMA4A / SEM4A
|
Transcripts
for SEMA4A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SEMA4A gene (4 alternative transcripts): NM_001193300.1 NM_001193301.1 NM_001193302.1 NM_022367.3 Unigene Cluster for SEMA4A: Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A Hs.408846 [show with all ESTs]Unigene Representative Sequence: NM_02236716 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000435124 ENST00000414683 ENST00000355014(uc001fnl.3) ENST00000485575
ENST00000368285(uc009wrq.3 uc001fnm.3 uc001fnn.3) ENST00000368284
ENST00000368283 ENST00000438830 ENST00000368282(uc001fno.3) ENST00000470306
ENST00000487358 ENST00000466698 ENST00000469065 ENST00000462892 ENST00000484155
ENST00000368286
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA4A (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA4A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): SEMA4A (NM_022367) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SEMA4A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA4A |
Additional cDNA sequence: AB029394.1 AK022349.1 AK091127.1 AK290353.1 AK296693.1 AK315547.1 AY358531.1 BC020974.1 BX640891.1 13 DOTS entries: DT.213060 DT.101979818 DT.100754109 DT.95227693 DT.100022714 DT.121420323 DT.86842043 DT.91803467 DT.100720190 DT.40229237 DT.91675054 DT.92420163 DT.95132610 24/102 AceView cDNA sequences (see all 102): BM694992 AA971074 AU122411 BC020974 BM666780 BX640891 BM806752 CA393520 NM_022367 AY358531 BQ057192 CR623694 BI914790 BP346261 AK022416 BP357148 BX367243 AB029394 BQ883972 CK819349 BG618720 BX384966 AW593031 BX390196
GeneLoc Exon Structure
5/21 Alternative Splicing Database (ASD) splice patterns (SP) for SEMA4A (see all 21) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | · | 6g | · | 6h | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | · | 9d | · | 9e | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | |
| ExUns: | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21a | · | 21b | · | 21c |
|---|
|
| SP1: | | | | | - | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | - | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | - | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SEMA4A
|
Expression
for SEMA4A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SEMA4A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGGGATCTG
About this image
See SEMA4A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEMA4A
SOURCE GeneReport for Unigene cluster: Hs.408846
SABiosciences Custom PCR Arrays for SEMA4A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEMA4A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEMA4A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA4A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA4A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA4A |
Orthologs
for SEMA4A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SEMA4A gene from 5/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
SEMA3F6 |
-- |
30(a) |
possible ortholog |
GL343512.1(1500-9205) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.104452 |
Transcribed sequence with weak similarity to protein more |
75.75(n) |
|
137710594 |
zebrafish
(Danio rerio) |
Actinopterygii |
si:dkey-78d16.21 |
si:dkey-78d16.2 |
49.97(n)
42.02(a) |
|
571290 XM_694864.3 XP_699956.3 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Sema-2a6Sema-2b6 |
Semaphorin-2b |
22(a)21(a) |
possible orthologpossible ortholog |
2R(12387701-12420934) 2R(12274029-12319263) |
worm
(Caenorhabditis elegans) |
Secernentea |
mab-206smp-26 |
SeMaPhorin related family member (smp-2) |
20(a)18(a) |
possible orthologpossible ortholog |
I(1644590-1651382) I(3667127-3671705) |
ENSEMBL Gene Tree for SEMA4A (if available)
TreeFam Gene Tree for SEMA4A (if available) |
Paralogs
for SEMA4A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SEMA4A gene
- SEMA3C2 SEMA4F2 SEMA3E2 SEMA4B2 SEMA3F2 SEMA4C2 SEMA4G2 SEMA4D2
- SEMA3A2 SEMA3G2 SEMA3D2
18/20 SIMAP similar genes for SEMA4A using alignment to 6 protein entries: SEM4A_HUMAN (see all proteins)
(see all similar genes):DKFZp686D04248 SEMA6B SEMA4C SEMA5B SEMA6A DKFZp686A04130
SEMA4D SEMA4B SEMA4D variant protein SEMA6C SEMA3F SEMA5A
SEMA3D SEMA6D SEMA4G SEMA4F PLXNC1 SEMA3A
SEMA4A for paralogs About GeneDecksing
|
Genomic Variants
for SEMA4A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SEMA4A (156117157 - 156147543 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SEMA4A: --
Human Gene Mutation Database (HGMD): SEMA4A
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEMA4A |
|
Disorders
/ Diseases
for SEMA4A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SEMA4A for disorders About GeneDecksing
OMIM gene information: 607292
OMIM disorders: 610282 610283
UniProtKB/Swiss-Prot: SEM4A_HUMAN, Q9H3S1
Defects in SEMA4A are the cause of retinitis pigmentosa type 35 (RP35) [MIM:610282]. RP leads to degenerationof retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field.As their condition progresses, they lose their far peripheral visual field and eventually central vision as well Defects in SEMA4A are the cause of cone-rod dystrophy type 10 (CORD10) [MIM:610283]. CORDs are inheritedretinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigmentdeposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptorsfollowed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field,followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa
11  diseases for SEMA4A: About MalaCardscone-rod dystrophy retinitis pigmentosa cone-rod dystrophy 10 retinitis pigmentosa 35
retinitis pigmentary retinopathy hepatitis b retinal disease
blindness hepatitis hypoxia
Human Genome Epidemiology (HuGE) Navigator: SEMA4A (2 documents)
Export disorders for SEMA4A gene to outside databases
|
Publications
for SEMA4A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SEMA4A gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with SEMA4A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of novel mutations in the SEMA4A gene associated with retinal degenerative diseases. (PubMed id 16199541)1, 2, 9 Abid A.... Khaliq S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. (PubMed id 7748561)1, 3 Puschel A.W....Betz H. (1995)
- Immune semaphorins: a new area of semaphorin research. (PubMed id 12893810)1, 9 Kumanogoh A. and Kikutani H. (2003)
- Elevation of Sema4A implicates Th cell skewing and the efficacy of IFN-b therapy in multiple sclerosis. (PubMed id 22491253)1 Nakatsuji Y....Kumanogoh A. (2012)
- SEMA4A mutations lead to susceptibility to light irrad iation, oxidative stress, and ER stress in retinal pigment epithelial cells. (PubMed id 22956603)1 Tsuruma K....Hara H. (2012)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Simultaneous Mutation Detection in 90 Retinal Disease Genes in Multiple Patients Using a Custom-designed 300-kb Retinal Resequencing Chip. (PubMed id 20801516)1 Booij J.C....Florijn R.J. (2010)
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External Searches for SEMA4A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing SEMA4A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing SEMA4A gene
(According to HUGE)
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Specialized Databases showing SEMA4A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for SEMA4A | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for SEMA4A gene:
Search GeneIP for patents involving SEMA4A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SEMA4A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA4A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEMA4A | | | OriGene Protein Over-expression Lysate for SEMA4A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SEMA4A | | OriGene 3'-UTR Clone for SEMA4A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA4A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA4A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SEMA4A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SEMA4A | | OriGene Custom Protein Services for SEMA4A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SEMA4A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEMA4A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA4A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA4A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA4A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA4A |
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| | | | Search Tocris compounds for SEMA4A |
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 | | | SEMA4A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA4A |
|  |  |  | | | | Search ThermoFisher Antibodies for SEMA4A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA4A |
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