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Aliases for SEMA3G Gene

Aliases for SEMA3G Gene

  • Semaphorin 3G 2 3
  • Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3G 2 3 5
  • Semaphorin Sem2 3 4
  • Sem2 3

External Ids for SEMA3G Gene

Previous GeneCards Identifiers for SEMA3G Gene

  • GC03M052444

Summaries for SEMA3G Gene

GeneCards Summary for SEMA3G Gene

SEMA3G (Semaphorin 3G) is a Protein Coding gene. Among its related pathways are Axon guidance. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA3F.

UniProtKB/Swiss-Prot for SEMA3G Gene

  • Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMA3G Gene

Genomics for SEMA3G Gene

Regulatory Elements for SEMA3G Gene

Enhancers for SEMA3G Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SEMA3G on UCSC Golden Path with GeneCards custom track

Promoters for SEMA3G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SEMA3G on UCSC Golden Path with GeneCards custom track

Genomic Location for SEMA3G Gene

52,433,053 bp from pter
52,445,085 bp from pter
12,033 bases
Minus strand

Genomic View for SEMA3G Gene

Genes around SEMA3G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEMA3G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEMA3G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA3G Gene

Proteins for SEMA3G Gene

  • Protein details for SEMA3G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q7L9D9
    • Q9H7Q3

    Protein attributes for SEMA3G Gene

    782 amino acids
    Molecular mass:
    86701 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SEMA3G Gene

Proteomics data for SEMA3G Gene at MOPED

Post-translational modifications for SEMA3G Gene

  • Glycosylation at Asn 44 and Asn 127
  • Modification sites at PhosphoSitePlus

Other Protein References for SEMA3G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SEMA3G Gene

Domains & Families for SEMA3G Gene

Suggested Antigen Peptide Sequences for SEMA3G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Belongs to the semaphorin family.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Sema domain.
  • Belongs to the semaphorin family.
genes like me logo Genes that share domains with SEMA3G: view

Function for SEMA3G Gene

Molecular function for SEMA3G Gene

UniProtKB/Swiss-Prot Function:
Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity).
genes like me logo Genes that share phenotypes with SEMA3G: view

Animal Models for SEMA3G Gene

MGI Knock Outs for SEMA3G:

Animal Model Products

  • Taconic Biosciences Mouse Models for SEMA3G

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SEMA3G Gene

Localization for SEMA3G Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA3G Gene


Subcellular locations from

Jensen Localization Image for SEMA3G Gene COMPARTMENTS Subcellular localization image for SEMA3G gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for SEMA3G Gene

Pathways & Interactions for SEMA3G Gene

SuperPathways for SEMA3G Gene

Superpath Contained pathways
1 Axon guidance
genes like me logo Genes that share pathways with SEMA3G: view

Pathways by source for SEMA3G Gene

1 KEGG pathway for SEMA3G Gene

Interacting Proteins for SEMA3G Gene

Gene Ontology (GO) - Biological Process for SEMA3G Gene


No data available for SIGNOR curated interactions for SEMA3G Gene

Drugs & Compounds for SEMA3G Gene

No Compound Related Data Available

Transcripts for SEMA3G Gene

mRNA/cDNA for SEMA3G Gene

Unigene Clusters for SEMA3G Gene

Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA3G Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: -
SP2: - - -

Relevant External Links for SEMA3G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEMA3G Gene

mRNA expression in normal human tissues for SEMA3G Gene

mRNA differential expression in normal tissues according to GTEx for SEMA3G Gene

This gene is overexpressed in Adipose - Subcutaneous (x7.7), Adipose - Visceral (Omentum) (x6.2), and Breast - Mammary Tissue (x5.2).

Protein differential expression in normal tissues from HIPED for SEMA3G Gene

This gene is overexpressed in Cerebrospinal fluid (50.2) and Adipocyte (18.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SEMA3G Gene

SOURCE GeneReport for Unigene cluster for SEMA3G Gene Hs.59729

genes like me logo Genes that share expression patterns with SEMA3G: view

Protein tissue co-expression partners for SEMA3G Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SEMA3G Gene

Orthologs for SEMA3G Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEMA3G Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SEMA3G 35
  • 86.74 (n)
  • 88.56 (a)
  • 88 (a)
(Canis familiaris)
Mammalia SEMA3G 35
  • 87.44 (n)
  • 89.12 (a)
  • 89 (a)
(Mus musculus)
Mammalia Sema3g 35
  • 84.74 (n)
  • 86.54 (a)
Sema3g 16
Sema3g 36
  • 87 (a)
(Pan troglodytes)
Mammalia SEMA3G 35
  • 99.32 (n)
  • 99.62 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Sema3g 35
  • 85.2 (n)
  • 87.23 (a)
(Monodelphis domestica)
Mammalia SEMA3G 36
  • 78 (a)
(Gallus gallus)
Aves SEMA3G 35
  • 70.5 (n)
  • 66.34 (a)
  • 65 (a)
(Anolis carolinensis)
Reptilia SEMA3G 36
  • 64 (a)
(Danio rerio)
Actinopterygii sema3bl 35
  • 62.63 (n)
  • 61.9 (a)
sema3bl 36
  • 57 (a)
Species with no ortholog for SEMA3G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEMA3G Gene

Gene Tree for SEMA3G (if available)
Gene Tree for SEMA3G (if available)

Paralogs for SEMA3G Gene

(9) SIMAP similar genes for SEMA3G Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SEMA3G: view

Variants for SEMA3G Gene

Sequence variations from dbSNP and Humsavar for SEMA3G Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_030292 -
VAR_051929 -
rs34540591 - 52,440,758(+) CCTGA(C/T)GGTGC reference, missense
rs82825 -- 52,437,926(-) ACTCA(C/T)CCCTG intron-variant
rs613519 -- 52,434,924(+) AAGCC(A/C/G/T)GAGCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SEMA3G Gene

Variant ID Type Subtype PubMed ID
nsv876789 CNV Loss 21882294
nsv834696 CNV Loss 17160897
nsv834697 CNV Loss 17160897
dgv5137n71 CNV Loss 21882294
esv2725273 CNV Deletion 23290073
esv2725275 CNV Deletion 23290073
esv2725276 CNV Deletion 23290073
nsv236985 CNV Loss 16902084

Variation tolerance for SEMA3G Gene

Residual Variation Intolerance Score: 8.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.69; 46.21% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SEMA3G Gene

Disorders for SEMA3G Gene

Relevant External Links for SEMA3G

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SEMA3G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEMA3G Gene

Publications for SEMA3G Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48 67
  2. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A. … Ohara O. (DNA Res. 2000) 2 3
  3. PPAR-I^ promotes endothelial cell migration by inducing the expression of Sema3g. (PMID: 25335934) Liu W. … Wang N. (J. Cell. Biochem. 2015) 3
  4. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S. … Sullivan P.F. (Nat. Genet. 2013) 3
  5. Effects of SEMA3G on migration and invasion of glioma cells. (PMID: 22562223) Zhou X. … Yu R. (Oncol. Rep. 2012) 3

Products for SEMA3G Gene

Sources for SEMA3G Gene