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Aliases for SEMA3G Gene

Aliases for SEMA3G Gene

  • Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3G 2 3
  • Semaphorin Sem2 3 4
  • Semaphorin-3G 3
  • Sem2 3

External Ids for SEMA3G Gene

Previous GeneCards Identifiers for SEMA3G Gene

  • GC03M052444

Summaries for SEMA3G Gene

GeneCards Summary for SEMA3G Gene

SEMA3G (Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3G) is a Protein Coding gene. Among its related pathways are Axon guidance. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA4G.

UniProtKB/Swiss-Prot for SEMA3G Gene

  • Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMA3G Gene

Genomics for SEMA3G Gene

Regulatory Elements for SEMA3G Gene

Genomic Location for SEMA3G Gene

Start:
52,433,053 bp from pter
End:
52,445,096 bp from pter
Size:
12,044 bases
Orientation:
Minus strand

Genomic View for SEMA3G Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEMA3G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA3G Gene

Proteins for SEMA3G Gene

  • Protein details for SEMA3G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS98-SEM3G_HUMAN
    Recommended name:
    Semaphorin-3G
    Protein Accession:
    Q9NS98
    Secondary Accessions:
    • Q7L9D9
    • Q9H7Q3

    Protein attributes for SEMA3G Gene

    Size:
    782 amino acids
    Molecular mass:
    86701 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SEMA3G Gene

Proteomics data for SEMA3G Gene at MOPED

Post-translational modifications for SEMA3G Gene

  • Glycosylation at Asn44 and Asn127
  • Modification sites at PhosphoSitePlus

Other Protein References for SEMA3G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SEMA3G Gene

Domains for SEMA3G Gene

Gene Families for SEMA3G Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • SEMA :Semaphorins

Suggested Antigen Peptide Sequences for SEMA3G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS98

UniProtKB/Swiss-Prot:

SEM3G_HUMAN :
  • Q9NS98
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Sema domain.
Family:
  • Belongs to the semaphorin family.
genes like me logo Genes that share domains with SEMA3G: view

Function for SEMA3G Gene

Molecular function for SEMA3G Gene

UniProtKB/Swiss-Prot Function: Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity).

Gene Ontology (GO) - Molecular Function for SEMA3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SEMA3G: view

Phenotypes for SEMA3G Gene

genes like me logo Genes that share phenotypes with SEMA3G: view

Animal Model Products

CRISPR Products

miRNA for SEMA3G Gene

miRTarBase miRNAs that target SEMA3G

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEMA3G

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEMA3G Gene

Localization for SEMA3G Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA3G Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEMA3G Gene COMPARTMENTS Subcellular localization image for SEMA3G gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SEMA3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with SEMA3G: view

Pathways for SEMA3G Gene

SuperPathways for SEMA3G Gene

Superpath Contained pathways
1 Axon guidance
genes like me logo Genes that share pathways with SEMA3G: view

Pathways by source for SEMA3G Gene

1 KEGG pathway for SEMA3G Gene

Interacting Proteins for SEMA3G Gene

Gene Ontology (GO) - Biological Process for SEMA3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
genes like me logo Genes that share ontologies with SEMA3G: view

Transcripts for SEMA3G Gene

mRNA/cDNA for SEMA3G Gene

Unigene Clusters for SEMA3G Gene

Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEMA3G

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SEMA3G

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA3G Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: -
SP2: - - -
SP3:

Relevant External Links for SEMA3G Gene

GeneLoc Exon Structure for
SEMA3G
ECgene alternative splicing isoforms for
SEMA3G

Expression for SEMA3G Gene

mRNA expression in normal human tissues for SEMA3G Gene

mRNA differential expression in normal tissues according to GTEx for SEMA3G Gene

This gene is overexpressed in Adipose - Subcutaneous (7.7), Adipose - Visceral (Omentum) (6.2), and Breast - Mammary Tissue (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SEMA3G Gene

SOURCE GeneReport for Unigene cluster for SEMA3G Gene Hs.59729

genes like me logo Genes that share expressions with SEMA3G: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SEMA3G Gene

Orthologs for SEMA3G Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEMA3G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEMA3G 35
  • 99.32 (n)
  • 99.62 (a)
SEMA3G 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SEMA3G 35
  • 86.74 (n)
  • 88.56 (a)
SEMA3G 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEMA3G 35
  • 87.44 (n)
  • 89.12 (a)
SEMA3G 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sema3g 35
  • 84.74 (n)
  • 86.54 (a)
Sema3g 16
Sema3g 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEMA3G 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sema3g 35
  • 85.2 (n)
  • 87.23 (a)
chicken
(Gallus gallus)
Aves SEMA3G 35
  • 70.5 (n)
  • 66.34 (a)
SEMA3G 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEMA3G 36
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii sema3bl 35
  • 62.63 (n)
  • 61.9 (a)
sema3bl 36
  • 57 (a)
OneToOne
Species with no ortholog for SEMA3G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEMA3G Gene

ENSEMBL:
Gene Tree for SEMA3G (if available)
TreeFam:
Gene Tree for SEMA3G (if available)

Paralogs for SEMA3G Gene

Selected SIMAP similar genes for SEMA3G Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SEMA3G: view

Variants for SEMA3G Gene

Sequence variations from dbSNP and Humsavar for SEMA3G Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs82825 -- 52,437,926(-) ACTCA(C/T)CCCTG intron-variant, downstream-variant-500B
rs559104 -- 52,444,463(+) CAAAC(A/T)GGGCA intron-variant
rs559107 -- 52,444,464(+) AAACA(C/G)GGCAC intron-variant
rs581072 -- 52,444,590(+) CGCAC(A/C)CAAAC intron-variant
rs613519 -- 52,434,924(+) AAGCC(A/C/G/T)GAGCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SEMA3G Gene

Variant ID Type Subtype PubMed ID
nsv876789 CNV Loss 21882294
nsv834696 CNV Loss 17160897
nsv834697 CNV Loss 17160897
dgv5137n71 CNV Loss 21882294
esv2725273 CNV Deletion 23290073
esv2725275 CNV Deletion 23290073
esv2725276 CNV Deletion 23290073
nsv236985 CNV Loss 16902084

Relevant External Links for SEMA3G Gene

HapMap Linkage Disequilibrium report
SEMA3G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEMA3G Gene

Disorders for SEMA3G Gene

Relevant External Links for SEMA3G

Genetic Association Database (GAD)
SEMA3G
Human Genome Epidemiology (HuGE) Navigator
SEMA3G
genes like me logo Genes that share disorders with SEMA3G: view

No data available for UniProtKB/Swiss-Prot for SEMA3G Gene

Publications for SEMA3G Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  4. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A. … Ohara O. (DNA Res. 2000) 2 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SEMA3G Gene

Sources for SEMA3G Gene

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