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Aliases for SEMA3G Gene

Aliases for SEMA3G Gene

  • Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3G 2 3
  • Semaphorin Sem2 3 4
  • Sem2 3

External Ids for SEMA3G Gene

Previous GeneCards Identifiers for SEMA3G Gene

  • GC03M052444

Summaries for SEMA3G Gene

GeneCards Summary for SEMA3G Gene

SEMA3G (Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3G) is a Protein Coding gene. Among its related pathways are Axon guidance. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA4G.

UniProtKB/Swiss-Prot for SEMA3G Gene

  • Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMA3G Gene

Genomics for SEMA3G Gene

Regulatory Elements for SEMA3G Gene

Genomic Location for SEMA3G Gene

Chromosome:
3
Start:
52,433,053 bp from pter
End:
52,445,085 bp from pter
Size:
12,033 bases
Orientation:
Minus strand

Genomic View for SEMA3G Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEMA3G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA3G Gene

Proteins for SEMA3G Gene

  • Protein details for SEMA3G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS98-SEM3G_HUMAN
    Recommended name:
    Semaphorin-3G
    Protein Accession:
    Q9NS98
    Secondary Accessions:
    • Q7L9D9
    • Q9H7Q3

    Protein attributes for SEMA3G Gene

    Size:
    782 amino acids
    Molecular mass:
    86701 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SEMA3G Gene

Proteomics data for SEMA3G Gene at MOPED

Post-translational modifications for SEMA3G Gene

  • Glycosylation at Asn 44 and Asn 127
  • Modification sites at PhosphoSitePlus

Other Protein References for SEMA3G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SEMA3G Gene

Domains & Families for SEMA3G Gene

Gene Families for SEMA3G Gene

Suggested Antigen Peptide Sequences for SEMA3G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS98

UniProtKB/Swiss-Prot:

SEM3G_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Belongs to the semaphorin family.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Sema domain.
Family:
  • Belongs to the semaphorin family.
genes like me logo Genes that share domains with SEMA3G: view

Function for SEMA3G Gene

Molecular function for SEMA3G Gene

UniProtKB/Swiss-Prot Function:
Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity).

Gene Ontology (GO) - Molecular Function for SEMA3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0030215 semaphorin receptor binding IBA --
GO:0038191 neuropilin binding IBA --
GO:0045499 chemorepellent activity IBA --
genes like me logo Genes that share ontologies with SEMA3G: view
genes like me logo Genes that share phenotypes with SEMA3G: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEMA3G

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SEMA3G Gene

Localization for SEMA3G Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA3G Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEMA3G Gene COMPARTMENTS Subcellular localization image for SEMA3G gene
Compartment Confidence
extracellular 5
cytosol 1

Gene Ontology (GO) - Cellular Components for SEMA3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0016020 membrane --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with SEMA3G: view

Pathways & Interactions for SEMA3G Gene

SuperPathways for SEMA3G Gene

Superpath Contained pathways
1 Axon guidance
genes like me logo Genes that share pathways with SEMA3G: view

Pathways by source for SEMA3G Gene

1 KEGG pathway for SEMA3G Gene

Interacting Proteins for SEMA3G Gene

Gene Ontology (GO) - Biological Process for SEMA3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001755 neural crest cell migration IBA --
GO:0030335 positive regulation of cell migration IBA --
GO:0048843 negative regulation of axon extension involved in axon guidance IBA --
GO:0050919 negative chemotaxis IBA --
GO:0071526 semaphorin-plexin signaling pathway IBA --
genes like me logo Genes that share ontologies with SEMA3G: view

No data available for SIGNOR curated interactions for SEMA3G Gene

Drugs & Compounds for SEMA3G Gene

No Compound Related Data Available

Transcripts for SEMA3G Gene

mRNA/cDNA for SEMA3G Gene

Unigene Clusters for SEMA3G Gene

Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEMA3G

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA3G Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: -
SP2: - - -
SP3:

Relevant External Links for SEMA3G Gene

GeneLoc Exon Structure for
SEMA3G
ECgene alternative splicing isoforms for
SEMA3G

Expression for SEMA3G Gene

mRNA expression in normal human tissues for SEMA3G Gene

mRNA differential expression in normal tissues according to GTEx for SEMA3G Gene

This gene is overexpressed in Adipose - Subcutaneous (x7.7), Adipose - Visceral (Omentum) (x6.2), and Breast - Mammary Tissue (x5.2).

Protein differential expression in normal tissues from HIPED for SEMA3G Gene

This gene is overexpressed in Cerebrospinal fluid (50.2) and Adipocyte (18.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SEMA3G Gene



SOURCE GeneReport for Unigene cluster for SEMA3G Gene Hs.59729

genes like me logo Genes that share expression patterns with SEMA3G: view

Protein tissue co-expression partners for SEMA3G Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SEMA3G Gene

Orthologs for SEMA3G Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEMA3G Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SEMA3G 35
  • 86.74 (n)
  • 88.56 (a)
SEMA3G 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEMA3G 35
  • 87.44 (n)
  • 89.12 (a)
SEMA3G 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sema3g 35
  • 84.74 (n)
  • 86.54 (a)
Sema3g 16
Sema3g 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SEMA3G 35
  • 99.32 (n)
  • 99.62 (a)
SEMA3G 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sema3g 35
  • 85.2 (n)
  • 87.23 (a)
oppossum
(Monodelphis domestica)
Mammalia SEMA3G 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEMA3G 35
  • 70.5 (n)
  • 66.34 (a)
SEMA3G 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEMA3G 36
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii sema3bl 35
  • 62.63 (n)
  • 61.9 (a)
sema3bl 36
  • 57 (a)
OneToOne
Species with no ortholog for SEMA3G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEMA3G Gene

ENSEMBL:
Gene Tree for SEMA3G (if available)
TreeFam:
Gene Tree for SEMA3G (if available)

Paralogs for SEMA3G Gene

(9) SIMAP similar genes for SEMA3G Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SEMA3G: view

Variants for SEMA3G Gene

Sequence variations from dbSNP and Humsavar for SEMA3G Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs82825 -- 52,437,926(-) ACTCA(C/T)CCCTG intron-variant
rs111275946 -- 52,433,457(+) TGAGT(A/G/T)CAGAG utr-variant-3-prime
rs111301698 -- 52,440,464(+) TTGAA(A/G)ACCTC synonymous-codon, reference
rs141952351 -- 52,438,595(+) GGAGA(C/T)GGGTT intron-variant
rs142042017 -- 52,436,025(+) CCTGC(A/G)GAACA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SEMA3G Gene

Variant ID Type Subtype PubMed ID
nsv876789 CNV Loss 21882294
nsv834696 CNV Loss 17160897
nsv834697 CNV Loss 17160897
dgv5137n71 CNV Loss 21882294
esv2725273 CNV Deletion 23290073
esv2725275 CNV Deletion 23290073
esv2725276 CNV Deletion 23290073
nsv236985 CNV Loss 16902084

Variation tolerance for SEMA3G Gene

Residual Variation Intolerance Score: 8.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.69; 46.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEMA3G Gene

HapMap Linkage Disequilibrium report
SEMA3G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEMA3G Gene

Disorders for SEMA3G Gene

Relevant External Links for SEMA3G

Genetic Association Database (GAD)
SEMA3G
Human Genome Epidemiology (HuGE) Navigator
SEMA3G
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEMA3G
genes like me logo Genes that share disorders with SEMA3G: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEMA3G Gene

Publications for SEMA3G Gene

  1. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A. … Ohara O. (DNA Res. 2000) 2 67
  2. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S. … Sullivan P.F. (Nat. Genet. 2013) 67
  3. Effects of SEMA3G on migration and invasion of glioma cells. (PMID: 22562223) Zhou X. … Yu R. (Oncol. Rep. 2012) 67
  4. Differential endothelial transcriptomics identifies semaphorin 3G as a vascular class 3 semaphorin. (PMID: 20947821) Kutschera S. … Augustin H.G. (Arterioscler. Thromb. Vasc. Biol. 2011) 67
  5. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) (Nat. Genet. 2011) 67

Products for SEMA3G Gene

Sources for SEMA3G Gene

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