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Aliases for SEMA3G Gene

Aliases for SEMA3G Gene

  • Semaphorin 3G 2 3 5
  • Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3G 2 3
  • Semaphorin Sem2 3 4
  • Semaphorin-3G 3
  • Sem2 3

External Ids for SEMA3G Gene

Previous GeneCards Identifiers for SEMA3G Gene

  • GC03M052444

Summaries for SEMA3G Gene

Entrez Gene Summary for SEMA3G Gene

  • The transcription of this gene is activated by PPAR-gamma, and the resulting protein product plays a role in endothelial cell migration. Expression of this gene also inhibits tumor cell migration and invasion. [provided by RefSeq, Jul 2016]

GeneCards Summary for SEMA3G Gene

SEMA3G (Semaphorin 3G) is a Protein Coding gene. Among its related pathways are Axon guidance. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA3E.

UniProtKB/Swiss-Prot for SEMA3G Gene

  • Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMA3G Gene

Genomics for SEMA3G Gene

Regulatory Elements for SEMA3G Gene

Enhancers for SEMA3G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F052274 1.4 Ensembl ENCODE 10.7 +162.2 162231 17.3 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 LOC101929054 PPM1M TWF2 ITIH4 PBRM1 GLYCTK RRP9 RFT1 RAD54L2 ENSG00000173366
GH03F052408 1.1 ENCODE 12.4 +34.5 34546 3.9 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SEMA3G TNNC1 NISCH GLYCTK-AS1 MIR135A1 GLYCTK WDR82 RNU6-856P NT5DC2 BAP1
GH03F052339 1.2 Ensembl ENCODE 10.6 +105.3 105252 0.3 NFRKB ARID4B YBX1 FEZF1 DMAP1 ZBTB40 ZNF2 RAD21 ZNF391 CREM DNAH1 GLYCTK-AS1 MIR135A1 WDR82 GLYCTK LOC101929054 TWF2 ENSG00000173366 TLR9 PPM1M
GH03F052466 1 VISTA FANTOM5 12.2 -23.1 -23096 3.0 ZNF740 MNT ZIC2 ZNF623 NR2F2 ZNF121 POLR2A SMARCA4 ZNF652 PRDM1 NT5DC2 SEMA3G STAB1 SMIM4 RNU6-856P RNU6ATAC16P PBRM1 GNL3 ENSG00000222345 ENSG00000252787
GH03F052372 0.7 Ensembl 11.3 +71.7 71728 1.4 CTCF RNF2 NFIA DPF2 ZBTB40 ZBTB7A EGR1 POLR2A ZBTB33 CREM PPM1M ITIH4 GLYCTK GLYCTK-AS1 MIR135A1 WDR82 SEMA3G NT5DC2 PPP2R5CP DNAH1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SEMA3G on UCSC Golden Path with GeneCards custom track

Promoters for SEMA3G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001364248 585 1401 ELF3 TBP ZNF133 ARID4B ZNF48 RAD21 RARA GATA4 ZNF366 SCRT2

Genomic Location for SEMA3G Gene

Chromosome:
3
Start:
52,433,053 bp from pter
End:
52,445,085 bp from pter
Size:
12,033 bases
Orientation:
Minus strand

Genomic View for SEMA3G Gene

Genes around SEMA3G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEMA3G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEMA3G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA3G Gene

Proteins for SEMA3G Gene

  • Protein details for SEMA3G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS98-SEM3G_HUMAN
    Recommended name:
    Semaphorin-3G
    Protein Accession:
    Q9NS98
    Secondary Accessions:
    • Q7L9D9
    • Q9H7Q3

    Protein attributes for SEMA3G Gene

    Size:
    782 amino acids
    Molecular mass:
    86701 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SEMA3G Gene

Post-translational modifications for SEMA3G Gene

  • Glycosylation at Asn 44 and Asn 127
  • Modification sites at PhosphoSitePlus

Other Protein References for SEMA3G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SEMA3G Gene

Domains & Families for SEMA3G Gene

Suggested Antigen Peptide Sequences for SEMA3G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS98

UniProtKB/Swiss-Prot:

SEM3G_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Belongs to the semaphorin family.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Sema domain.
Family:
  • Belongs to the semaphorin family.
genes like me logo Genes that share domains with SEMA3G: view

Function for SEMA3G Gene

Molecular function for SEMA3G Gene

UniProtKB/Swiss-Prot Function:
Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity).

Gene Ontology (GO) - Molecular Function for SEMA3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030215 semaphorin receptor binding IBA --
GO:0038191 neuropilin binding IBA --
GO:0045499 chemorepellent activity IBA --
genes like me logo Genes that share ontologies with SEMA3G: view
genes like me logo Genes that share phenotypes with SEMA3G: view

Animal Models for SEMA3G Gene

MGI Knock Outs for SEMA3G:

Animal Model Products

  • Taconic Biosciences Mouse Models for SEMA3G

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SEMA3G Gene

Localization for SEMA3G Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA3G Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEMA3G gene
Compartment Confidence
extracellular 5
plasma membrane 3
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SEMA3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with SEMA3G: view

Pathways & Interactions for SEMA3G Gene

SuperPathways for SEMA3G Gene

SuperPathway Contained pathways
1 Axon guidance
genes like me logo Genes that share pathways with SEMA3G: view

Pathways by source for SEMA3G Gene

1 KEGG pathway for SEMA3G Gene

Gene Ontology (GO) - Biological Process for SEMA3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001755 neural crest cell migration IBA --
GO:0030335 positive regulation of cell migration IBA --
GO:0048843 negative regulation of axon extension involved in axon guidance IBA --
GO:0050919 negative chemotaxis IBA --
GO:0071526 semaphorin-plexin signaling pathway IBA --
genes like me logo Genes that share ontologies with SEMA3G: view

No data available for SIGNOR curated interactions for SEMA3G Gene

Transcripts for SEMA3G Gene

mRNA/cDNA for SEMA3G Gene

Unigene Clusters for SEMA3G Gene

Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA3G Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: -
SP2: - - -
SP3:

Relevant External Links for SEMA3G Gene

GeneLoc Exon Structure for
SEMA3G
ECgene alternative splicing isoforms for
SEMA3G

Expression for SEMA3G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SEMA3G Gene

mRNA differential expression in normal tissues according to GTEx for SEMA3G Gene

This gene is overexpressed in Adipose - Subcutaneous (x7.7), Adipose - Visceral (Omentum) (x6.2), and Breast - Mammary Tissue (x5.2).

Protein differential expression in normal tissues from HIPED for SEMA3G Gene

This gene is overexpressed in Cerebrospinal fluid (50.2) and Adipocyte (18.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SEMA3G Gene



Protein tissue co-expression partners for SEMA3G Gene

NURSA nuclear receptor signaling pathways regulating expression of SEMA3G Gene:

SEMA3G

SOURCE GeneReport for Unigene cluster for SEMA3G Gene:

Hs.59729
genes like me logo Genes that share expression patterns with SEMA3G: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SEMA3G Gene

Orthologs for SEMA3G Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEMA3G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEMA3G 34 35
  • 99.32 (n)
dog
(Canis familiaris)
Mammalia SEMA3G 34 35
  • 87.44 (n)
cow
(Bos Taurus)
Mammalia SEMA3G 34 35
  • 86.74 (n)
rat
(Rattus norvegicus)
Mammalia Sema3g 34
  • 85.2 (n)
mouse
(Mus musculus)
Mammalia Sema3g 34 16 35
  • 84.74 (n)
oppossum
(Monodelphis domestica)
Mammalia SEMA3G 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEMA3G 34 35
  • 70.5 (n)
lizard
(Anolis carolinensis)
Reptilia SEMA3G 35
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii sema3bl 34 35
  • 62.63 (n)
Species where no ortholog for SEMA3G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEMA3G Gene

ENSEMBL:
Gene Tree for SEMA3G (if available)
TreeFam:
Gene Tree for SEMA3G (if available)

Paralogs for SEMA3G Gene

(9) SIMAP similar genes for SEMA3G Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SEMA3G: view

Variants for SEMA3G Gene

Sequence variations from dbSNP and Humsavar for SEMA3G Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs111275946 -- 52,433,457(+) TGAGT(A/G)CAGAG utr-variant-3-prime
rs111301698 -- 52,440,464(+) TTGAA(A/G)ACCTC reference, synonymous-codon
rs111410797 -- 52,436,141(+) GCCCC(A/T)GCTTT intron-variant
rs111456472 -- 52,437,558(+) TCTGC(A/G)AGAGC reference, missense
rs111617878 -- 52,441,573(+) CCTCA(C/G/T)CGTGC upstream-variant-2KB, splice-donor-variant

Structural Variations from Database of Genomic Variants (DGV) for SEMA3G Gene

Variant ID Type Subtype PubMed ID
nsv954860 CNV deletion 24416366
nsv834697 CNV loss 17160897
nsv834696 CNV loss 17160897
nsv590303 CNV loss 21841781
nsv236985 CNV deletion 16902084
nsv1148206 CNV deletion 26484159
nsv1130796 CNV deletion 24896259
esv2725276 CNV deletion 23290073
esv2725275 CNV deletion 23290073
esv2725273 CNV deletion 23290073

Variation tolerance for SEMA3G Gene

Residual Variation Intolerance Score: 8.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.69; 46.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEMA3G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEMA3G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEMA3G Gene

Disorders for SEMA3G Gene

Relevant External Links for SEMA3G

Genetic Association Database (GAD)
SEMA3G
Human Genome Epidemiology (HuGE) Navigator
SEMA3G
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEMA3G

No disorders were found for SEMA3G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEMA3G Gene

Publications for SEMA3G Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A. … Ohara O. (DNA Res. 2000) 2 3 64
  5. PPAR-I^ promotes endothelial cell migration by inducing the expression of Sema3g. (PMID: 25335934) Liu W. … Wang N. (J. Cell. Biochem. 2015) 3 64

Products for SEMA3G Gene

Sources for SEMA3G Gene

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