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Aliases for SEMA3G Gene

Aliases for SEMA3G Gene

  • Semaphorin 3G 2 3 5
  • Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3G 2 3
  • Semaphorin Sem2 3 4
  • Semaphorin-3G 3
  • Sem2 3

External Ids for SEMA3G Gene

Previous GeneCards Identifiers for SEMA3G Gene

  • GC03M052444

Summaries for SEMA3G Gene

Entrez Gene Summary for SEMA3G Gene

  • The transcription of this gene is activated by PPAR-gamma, and the resulting protein product plays a role in endothelial cell migration. Expression of this gene also inhibits tumor cell migration and invasion. [provided by RefSeq, Jul 2016]

GeneCards Summary for SEMA3G Gene

SEMA3G (Semaphorin 3G) is a Protein Coding gene. Among its related pathways are Axon guidance. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA3E.

UniProtKB/Swiss-Prot for SEMA3G Gene

  • Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMA3G Gene

Genomics for SEMA3G Gene

Regulatory Elements for SEMA3G Gene

Enhancers for SEMA3G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G052274 1.7 Ensembl ENCODE dbSUPER 10.7 +162.2 162231 17.3 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 SSRP1 LOC101929054 PPM1M TWF2 ITIH4 PBRM1 GLYCTK RRP9 RFT1 RAD54L2 ENSG00000173366
GH03G052466 1.2 VISTA FANTOM5 dbSUPER 12.2 -23.1 -23096 3.0 ZNF740 MNT ZNF623 ZIC2 NR2F2 ZNF121 SMARCA4 POLR2A ZNF652 PRDM1 NT5DC2 SEMA3G STAB1 SMIM4 RNU6-856P RNU6ATAC16P PBRM1 GNL3 SNORD69 SNORD19B
GH03G052408 1.1 ENCODE 12.4 +34.5 34546 3.9 HDGF PKNOX1 MLX CREB3L1 SIN3A ARID4B DMAP1 ZNF2 YY1 ZNF766 SEMA3G TNNC1 NISCH RAD54L2 GLYCTK-AS1 MIR135A1 WDR82 GLYCTK RNU6-856P NT5DC2
GH03G052339 1.2 Ensembl ENCODE 10.6 +105.3 105285 0.4 HDGF FOXA2 ARNT NFRKB ZSCAN4 ARID4B FEZF1 DMAP1 YBX1 ZNF2 DNAH1 GLYCTK-AS1 MIR135A1 GLYCTK WDR82 LOC101929054 TWF2 ENSG00000173366 TLR9 PPM1M
GH03G052482 0.9 ENCODE dbSUPER 11.8 -37.2 -37235 0.2 CTCF RAD21 POLR2A IKZF1 SCRT2 ZBTB33 KDM6A HNRNPL NISCH SMIM4 NT5DC2 TNNC1 SEMA3G GLYCTK-AS1 MIR135A1 WDR82 GLYCTK PIR37247
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SEMA3G on UCSC Golden Path with GeneCards custom track

Genomic Location for SEMA3G Gene

Chromosome:
3
Start:
52,433,053 bp from pter
End:
52,445,085 bp from pter
Size:
12,033 bases
Orientation:
Minus strand

Genomic View for SEMA3G Gene

Genes around SEMA3G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEMA3G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEMA3G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA3G Gene

Proteins for SEMA3G Gene

  • Protein details for SEMA3G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS98-SEM3G_HUMAN
    Recommended name:
    Semaphorin-3G
    Protein Accession:
    Q9NS98
    Secondary Accessions:
    • Q7L9D9
    • Q9H7Q3

    Protein attributes for SEMA3G Gene

    Size:
    782 amino acids
    Molecular mass:
    86701 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SEMA3G Gene

Post-translational modifications for SEMA3G Gene

  • Glycosylation at Asn44 and Asn127
  • Modification sites at PhosphoSitePlus

Other Protein References for SEMA3G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SEMA3G Gene

Domains & Families for SEMA3G Gene

Suggested Antigen Peptide Sequences for SEMA3G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS98

UniProtKB/Swiss-Prot:

SEM3G_HUMAN :
  • Belongs to the semaphorin family.
Family:
  • Belongs to the semaphorin family.
genes like me logo Genes that share domains with SEMA3G: view

Function for SEMA3G Gene

Molecular function for SEMA3G Gene

UniProtKB/Swiss-Prot Function:
Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity).

Gene Ontology (GO) - Molecular Function for SEMA3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding ISS --
genes like me logo Genes that share ontologies with SEMA3G: view
genes like me logo Genes that share phenotypes with SEMA3G: view

Animal Models for SEMA3G Gene

MGI Knock Outs for SEMA3G:

Animal Model Products

  • Taconic Biosciences Mouse Models for SEMA3G

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SEMA3G Gene

Localization for SEMA3G Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA3G Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEMA3G gene
Compartment Confidence
extracellular 5
plasma membrane 3
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SEMA3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with SEMA3G: view

Pathways & Interactions for SEMA3G Gene

SuperPathways for SEMA3G Gene

SuperPathway Contained pathways
1 Axon guidance
genes like me logo Genes that share pathways with SEMA3G: view

Pathways by source for SEMA3G Gene

1 KEGG pathway for SEMA3G Gene

Gene Ontology (GO) - Biological Process for SEMA3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030517 negative regulation of axon extension ISS --
genes like me logo Genes that share ontologies with SEMA3G: view

No data available for SIGNOR curated interactions for SEMA3G Gene

Drugs & Compounds for SEMA3G Gene

No Compound Related Data Available

Transcripts for SEMA3G Gene

mRNA/cDNA for SEMA3G Gene

Unigene Clusters for SEMA3G Gene

Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA3G Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: -
SP2: - - -
SP3:

Relevant External Links for SEMA3G Gene

GeneLoc Exon Structure for
SEMA3G
ECgene alternative splicing isoforms for
SEMA3G

Expression for SEMA3G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEMA3G Gene

mRNA differential expression in normal tissues according to GTEx for SEMA3G Gene

This gene is overexpressed in Adipose - Subcutaneous (x7.7), Adipose - Visceral (Omentum) (x6.2), and Breast - Mammary Tissue (x5.2).

Protein differential expression in normal tissues from HIPED for SEMA3G Gene

This gene is overexpressed in Cerebrospinal fluid (50.2) and Adipocyte (18.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SEMA3G Gene



Protein tissue co-expression partners for SEMA3G Gene

NURSA nuclear receptor signaling pathways regulating expression of SEMA3G Gene:

SEMA3G

SOURCE GeneReport for Unigene cluster for SEMA3G Gene:

Hs.59729

Evidence on tissue expression from TISSUES for SEMA3G Gene

  • Spleen(4.2)
  • Heart(2.4)
  • Muscle(2.3)
  • Blood(2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with SEMA3G: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEMA3G Gene

Orthologs for SEMA3G Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEMA3G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEMA3G 34 35
  • 99.32 (n)
dog
(Canis familiaris)
Mammalia SEMA3G 34 35
  • 87.44 (n)
cow
(Bos Taurus)
Mammalia SEMA3G 34 35
  • 86.74 (n)
rat
(Rattus norvegicus)
Mammalia Sema3g 34
  • 85.2 (n)
mouse
(Mus musculus)
Mammalia Sema3g 34 16 35
  • 84.74 (n)
oppossum
(Monodelphis domestica)
Mammalia SEMA3G 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEMA3G 34 35
  • 70.5 (n)
lizard
(Anolis carolinensis)
Reptilia SEMA3G 35
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii sema3bl 34 35
  • 62.63 (n)
Species where no ortholog for SEMA3G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEMA3G Gene

ENSEMBL:
Gene Tree for SEMA3G (if available)
TreeFam:
Gene Tree for SEMA3G (if available)

Paralogs for SEMA3G Gene

(9) SIMAP similar genes for SEMA3G Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SEMA3G: view

Variants for SEMA3G Gene

Sequence variations from dbSNP and Humsavar for SEMA3G Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000261205 -- 52,434,626(+) GGCTG(A/C/T)AGGGC utr-variant-3-prime
rs1000329877 -- 52,446,654(+) GGGTG(C/T)AAGCA intron-variant, upstream-variant-2KB
rs1000421456 -- 52,435,404(+) TAAGA(A/G)CACAG utr-variant-3-prime
rs1000628660 -- 52,440,655(+) CCAAG(C/G)CAAAG intron-variant
rs1001184700 -- 52,446,579(+) GCTGG(A/G)GAGCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SEMA3G Gene

Variant ID Type Subtype PubMed ID
esv2725273 CNV deletion 23290073
esv2725275 CNV deletion 23290073
esv2725276 CNV deletion 23290073
nsv1130796 CNV deletion 24896259
nsv1148206 CNV deletion 26484159
nsv236985 CNV deletion 16902084
nsv590303 CNV loss 21841781
nsv834696 CNV loss 17160897
nsv834697 CNV loss 17160897
nsv954860 CNV deletion 24416366

Variation tolerance for SEMA3G Gene

Residual Variation Intolerance Score: 8.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.69; 46.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEMA3G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEMA3G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEMA3G Gene

Disorders for SEMA3G Gene

Relevant External Links for SEMA3G

Genetic Association Database (GAD)
SEMA3G
Human Genome Epidemiology (HuGE) Navigator
SEMA3G
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEMA3G

No disorders were found for SEMA3G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEMA3G Gene

Publications for SEMA3G Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A. … Ohara O. (DNA Res. 2000) 2 3 64
  5. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. (PMID: 26598620) Dart A.E. … Wells C.M. (J. Cell Biol. 2015) 3 64

Products for SEMA3G Gene

Sources for SEMA3G Gene

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