SEMA3G Gene
protein-coding GIFtS: 47
GCID: GC03M052467
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sema domain, immunoglobulin domain (Ig), short basic domain,...
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Aliases
for SEMA3G gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted,(Semaphorin) 3G1 2 | | Sem21 | | Semaphorin Sem22 3 | | FLJ000141 | | Semaphorin-3G1 |
Export aliases for SEMA3G gene to outside databasesPrevious GC identifer: GC03M052444 |
Summaries
for SEMA3G gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SEM3G_HUMAN, Q9NS98Function: Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity)
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Genomic Views
for SEMA3G gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SEMA3G gene promoter:
Max1 Sp1 COUP Olf-1 COUP-TF Pax-4a ATF c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for SEMA3G
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA3G |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.1 Ensembl cytogenetic band: 3p21.1 HGNC cytogenetic band: 3p21.1SEMA3G Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M052467: view genomic region
(about GC identifiers)
Start:
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52,467,069 bp from pter |
End:
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52,479,101 bp from pter |
Size:
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12,033 bases |
Orientation:
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minus strand |
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Proteins
for SEMA3G gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SEM3G_HUMAN, Q9NS98 (See
protein sequence)Recommended Name: Semaphorin-3G precursor Size: 782 amino acids; 86701 Da
Subcellular location: Secreted (By similarity)
Secondary accessions: Q7L9D9 Q9H7Q3Explore the universe of human proteins at neXtProt for SEMA3G: NX_Q9NS98
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NS98
SEMA3G Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_064548.1
ENSEMBL proteins: ENSP00000231721 ENSP00000420291 ENSP00000419181
Human Recombinant Protein Products for SEMA3G:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | | GO:0016020 | membrane |
IEA | -- |
SEMA3G for ontologies About GeneDecksing
SEMA3G Antibody Products:
Assay Products for SEMA3G: |
Protein
Domains /
Families
for SEMA3G gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SEMA3G for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry Q9NS98ProtoNet protein and cluster: Q9NS98 2 Blocks protein families: IPB001627 Semaphorin/CD100 antigen IPB003599 Immunoglobulin subtype
UniProtKB/Swiss-Prot: SEM3G_HUMAN, Q9NS98Similarity: Belongs to the semaphorin familySimilarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domainSimilarity: Contains 1 Sema domain |
Function
for SEMA3G gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SEM3G_HUMAN, Q9NS98Function: Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity) Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
IEA | -- |
SEMA3G for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for SEMA3G:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Sema3g):
SEMA3G for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA3G (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA3G
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SEMA3G (NM_020163) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SEMA3G | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA3G |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3G |
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Pathways & Interactions
for SEMA3G gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Axon guidance | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for SEMA3G):
SEMA3G for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEMA3G
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for SEMA3G (ENSP000002317214) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- |
SEMA3G for ontologies About GeneDecksing
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Drugs & Compounds
for SEMA3G gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SEMA3G
Search CenterWatch for drugs/clinical trials and news about SEMA3G / SEM3G
|
Transcripts
for SEMA3G gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SEMA3G gene: NM_020163.1 Unigene Cluster for SEMA3G: Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G Hs.59729 [show with all ESTs]Unigene Representative Sequence: NM_0201633 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000231721(uc003dea.1) ENST00000465657 ENST00000475739
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA3G (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA3G
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SEMA3G (NM_020163) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SEMA3G | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA3G |
Additional cDNA sequence: AB029496.1 AK024425.1 BC098104.1 BC098137.1 BC099724.1 1 DOTS entry: DT.211077 24/62 AceView cDNA sequences (see all 62): CA428183 CA449632 BF589439 BG152318 BQ614403 AK024425 AI750874 BM698350 NM_020163 BM509058 BM682454 BM511949 CA427097 AB029496 BV199087 BU145486 AA340640 AA321136 BQ017460 CB270779 BG115775 AI401364 CA427284 CD245766
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for SEMA3G About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
|---|
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| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SEMA3G
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Expression
for SEMA3G gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SEMA3G expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SEMA3G Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEMA3G
SOURCE GeneReport for Unigene cluster: Hs.59729
SABiosciences Custom PCR Arrays for SEMA3G
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEMA3G
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEMA3G | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA3G | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA3G | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3G |
Orthologs
for SEMA3G gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SEMA3G gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for SEMA3G (if available)
TreeFam Gene Tree for SEMA3G (if available) |
Paralogs
for SEMA3G gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SEMA3G gene
- SEMA3C2 SEMA4F2 SEMA3E2 SEMA4B2 SEMA3F2 SEMA4C2 SEMA4A2 SEMA4G2
- SEMA4D2 SEMA3A2 SEMA3D2
9 SIMAP similar genes for SEMA3G using alignment to 3 protein entries: SEM3G_HUMAN (see all proteins):SEMA3E SEMA3D SEMA3F SEMA3A SEMA3B SEMA3C
SEMA4B SEMA4D SEMA4D variant protein
SEMA3G for paralogs About GeneDecksing
|
Genomic Variants
for SEMA3G gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SEMA3G (52467069 - 52479101 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SEMA3G
1 CNV: 4338 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEMA3G |
|
Disorders
/ Diseases
for SEMA3G gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SEMA3G for disorders About MalaCards
SEMA3G for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: SEMA3G (3 documents)
Export disorders for SEMA3G gene to outside databases
|
Publications
for SEMA3G gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SEMA3G gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with SEMA3G) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)1, 3 Hattori A.... Ohara O. (2000)
- Effects of SEMA3G on migration and invasion of glioma cells. (PubMed id 22562223)1 Zhou X....Yu R. (2012)
- Differential endothelial transcriptomics identifies s emaphorin 3G as a vascular class 3 semaphorin. (PubMed id 20947821)1 Kutschera S....Augustin H.G. (2011)
- Large-scale genome-wide association analysis of bipol ar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1 Sklar P....Purcell S.M. (2011)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Semaphorin, neuropilin and VEGF expression in glial tumours: SEMA3G, a prognostic marker? (PubMed id 18781179)1 Karayan-Tapon L....Roche J. (2008)
- Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells. (PubMed id 18818766)1 Kigel B....Neufeld G. (2008)
|
External Searches for SEMA3G gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SEMA3G gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SEMA3G gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SEMA3G gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SEMA3G | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SEMA3G gene:
Search GeneIP for patents involving SEMA3G
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SEMA3G gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3G |
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