Aliases for SEMA3F Gene
External Ids for SEMA3F Gene
Previous GeneCards Identifiers for SEMA3F Gene
The semaphorins are a family of proteins that are involved in signaling. All the family members have a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues (Kolodkin et al., 1993 [PubMed 8269517]). Sequence comparisons have grouped the secreted semaphorins into 3 general classes, all of which also have an immunoglobulin domain. The semaphorin III family, consisting of human semaphorin III (SEMA3A; MIM 603961), chicken collapsin, and mouse semaphorins A, D, and E, all have a basic domain at the C terminus. Chicken collapsin contributes to path finding by axons during development by inhibiting extension of growth cones (Luo et al., 1993 [PubMed 8402908]) through an interaction with a collapsin response mediator protein of relative molecular mass 62K (CRMP62) (Goshima et al., 1995 [PubMed 7637782]), a putative homolog of an axonal guidance associated UNC33 gene product (MIM 601168). SEMA3F is a secreted member of the semaphorin III family.[supplied by OMIM, Mar 2008]
GeneCards Summary for SEMA3F Gene
SEMA3F (Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3F) is a Protein Coding gene. Diseases associated with SEMA3F include brachial plexus lesion and wallerian degeneration. Among its related pathways are Axon guidance. GO annotations related to this gene include receptor activity and chemorepellent activity. An important paralog of this gene is SEMA4G.
UniProtKB/Swiss-Prot for SEMA3F Gene
May play a role in cell motility and cell adhesion