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Aliases for SEMA3F Gene

Aliases for SEMA3F Gene

  • Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3F 2 3
  • Sema IV 2 3 4
  • Semaphorin IV 3 4
  • Sema III/F 3 4
  • Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, 3F 3
  • Semaphorin III/F 3
  • SEMA-IV 3
  • SEMA4 3
  • SEMAK 3

External Ids for SEMA3F Gene

Previous GeneCards Identifiers for SEMA3F Gene

  • GC03M049760
  • GC03M049931
  • GC03P050046
  • GC03P050151

Summaries for SEMA3F Gene

Entrez Gene Summary for SEMA3F Gene

  • The semaphorins are a family of proteins that are involved in signaling. All the family members have a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues (Kolodkin et al., 1993 [PubMed 8269517]). Sequence comparisons have grouped the secreted semaphorins into 3 general classes, all of which also have an immunoglobulin domain. The semaphorin III family, consisting of human semaphorin III (SEMA3A; MIM 603961), chicken collapsin, and mouse semaphorins A, D, and E, all have a basic domain at the C terminus. Chicken collapsin contributes to path finding by axons during development by inhibiting extension of growth cones (Luo et al., 1993 [PubMed 8402908]) through an interaction with a collapsin response mediator protein of relative molecular mass 62K (CRMP62) (Goshima et al., 1995 [PubMed 7637782]), a putative homolog of an axonal guidance associated UNC33 gene product (MIM 601168). SEMA3F is a secreted member of the semaphorin III family.[supplied by OMIM, Mar 2008]

GeneCards Summary for SEMA3F Gene

SEMA3F (Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3F) is a Protein Coding gene. Diseases associated with SEMA3F include brachial plexus lesion and wallerian degeneration. Among its related pathways are Axon guidance. GO annotations related to this gene include receptor activity and chemorepellent activity. An important paralog of this gene is SEMA4G.

UniProtKB/Swiss-Prot for SEMA3F Gene

  • May play a role in cell motility and cell adhesion

Gene Wiki entry for SEMA3F Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMA3F Gene

Genomics for SEMA3F Gene

Regulatory Elements for SEMA3F Gene

Transcription factor binding sites by QIAGEN in the SEMA3F gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SEMA3F Gene

50,155,045 bp from pter
50,189,075 bp from pter
34,031 bases
Plus strand

Genomic View for SEMA3F Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEMA3F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA3F Gene

Proteins for SEMA3F Gene

  • Protein details for SEMA3F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • C9JQ85
    • Q13274
    • Q13372
    • Q15704
    • Q6GTR4

    Protein attributes for SEMA3F Gene

    785 amino acids
    Molecular mass:
    88381 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SEMA3F Gene


neXtProt entry for SEMA3F Gene

Proteomics data for SEMA3F Gene at MOPED

Post-translational modifications for SEMA3F Gene

  • Glycosylation at Asn 53 and Asn 126
  • Modification sites at PhosphoSitePlus

Other Protein References for SEMA3F Gene

Antibody Products

  • R&D Systems Antibodies for SEMA3F (Semaphorin 3F)

No data available for DME Specific Peptides for SEMA3F Gene

Domains & Families for SEMA3F Gene

Gene Families for SEMA3F Gene

Suggested Antigen Peptide Sequences for SEMA3F Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Belongs to the semaphorin family.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Sema domain.
  • Belongs to the semaphorin family.
genes like me logo Genes that share domains with SEMA3F: view

Function for SEMA3F Gene

Molecular function for SEMA3F Gene

GENATLAS Biochemistry:
semaphorin 3F,secreted,expressed in mammary gland,kidney,fetal brain,lung,repellent of the nerve growth cone guidance
UniProtKB/Swiss-Prot Function:
May play a role in cell motility and cell adhesion

Gene Ontology (GO) - Molecular Function for SEMA3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0030215 semaphorin receptor binding IBA --
GO:0038191 neuropilin binding IBA --
GO:0045499 chemorepellent activity IDA 15814794
genes like me logo Genes that share ontologies with SEMA3F: view
genes like me logo Genes that share phenotypes with SEMA3F: view

Animal Models for SEMA3F Gene

MGI Knock Outs for SEMA3F:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEMA3F

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SEMA3F Gene

Localization for SEMA3F Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA3F Gene


Subcellular locations from

Jensen Localization Image for SEMA3F Gene COMPARTMENTS Subcellular localization image for SEMA3F gene
Compartment Confidence
extracellular 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SEMA3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 8786119
genes like me logo Genes that share ontologies with SEMA3F: view

Pathways & Interactions for SEMA3F Gene

SuperPathways for SEMA3F Gene

Superpath Contained pathways
1 Axon guidance
genes like me logo Genes that share pathways with SEMA3F: view

Pathways by source for SEMA3F Gene

1 KEGG pathway for SEMA3F Gene

SIGNOR curated interactions for SEMA3F Gene


Gene Ontology (GO) - Biological Process for SEMA3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001755 neural crest cell migration IBA --
GO:0007411 axon guidance IDA 15814794
GO:0021612 facial nerve structural organization IEA --
GO:0021637 trigeminal nerve structural organization IEA --
GO:0021675 nerve development ISS --
genes like me logo Genes that share ontologies with SEMA3F: view

Drugs & Compounds for SEMA3F Gene

(1) Additional Compounds for SEMA3F Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SEMA3F: view

Transcripts for SEMA3F Gene

Unigene Clusters for SEMA3F Gene

Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEMA3F

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA3F Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: -
SP2: - - - - -
SP3: - -
SP4: - - -
SP5: - -

Relevant External Links for SEMA3F Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEMA3F Gene

mRNA expression in normal human tissues for SEMA3F Gene

mRNA differential expression in normal tissues according to GTEx for SEMA3F Gene

This gene is overexpressed in Esophagus - Mucosa (x5.4).

Protein differential expression in normal tissues from HIPED for SEMA3F Gene

This gene is overexpressed in Vitreous humor (26.2), Plasma (19.0), and Amniocyte (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SEMA3F Gene

SOURCE GeneReport for Unigene cluster for SEMA3F Gene Hs.32981

mRNA Expression by UniProt/SwissProt for SEMA3F Gene

Tissue specificity: Expressed abundantly but differentially in a variety of neural and nonneural tissues. There is high expression in mammary gland, kidney, fetal brain, and lung and lower expression in heart and liver
genes like me logo Genes that share expression patterns with SEMA3F: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for SEMA3F Gene

Orthologs for SEMA3F Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEMA3F Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SEMA3F 35
  • 88.87 (n)
  • 93.12 (a)
  • 93 (a)
(Canis familiaris)
Mammalia SEMA3F 35
  • 90.96 (n)
  • 96.94 (a)
  • 97 (a)
(Mus musculus)
Mammalia Sema3f 35
  • 88.95 (n)
  • 96.42 (a)
Sema3f 16
Sema3f 36
  • 96 (a)
(Pan troglodytes)
Mammalia SEMA3F 35
  • 98.77 (n)
  • 98.47 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Sema3f 35
  • 89.04 (n)
  • 95.8 (a)
(Monodelphis domestica)
Mammalia SEMA3F 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia SEMA3F 36
  • 78 (a)
(Gallus gallus)
Aves SEMA3F 35
  • 78.27 (n)
  • 82.33 (a)
  • 76 (a)
(Anolis carolinensis)
Reptilia SEMA3F 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sema3f 35
  • 73.54 (n)
  • 81.11 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68870 35
(Danio rerio)
Actinopterygii sema3fb 35
  • 67.4 (n)
  • 70.96 (a)
sema3fa 36
  • 68 (a)
sema3fb 36
  • 69 (a)
sema3ga 36
  • 60 (a)
sema3gb 36
  • 61 (a)
Species with no ortholog for SEMA3F:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEMA3F Gene

Gene Tree for SEMA3F (if available)
Gene Tree for SEMA3F (if available)

Paralogs for SEMA3F Gene

genes like me logo Genes that share paralogs with SEMA3F: view

Variants for SEMA3F Gene

Sequence variations from dbSNP and Humsavar for SEMA3F Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs147919666 -- 50,169,988(+) GCCTC(A/C)TGGTG intron-variant
rs147698274 -- 50,182,751(+) GCCCC(A/G)CGGTG missense, reference, nc-transcript-variant
rs147680835 -- 50,185,446(+) AGACC(A/G)CGGGA missense, reference, downstream-variant-500B, synonymous-codon, nc-transcript-variant
rs147445085 -- 50,186,786(+) TGAGT(C/T)CTTGC intron-variant
rs147443541 -- 50,161,647(+) GTCTC(A/G)TGTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEMA3F Gene

Variant ID Type Subtype PubMed ID
nsv834690 CNV Loss 17160897
nsv515986 CNV Loss 19592680
nsv876768 CNV Gain 21882294
nsv523662 CNV Loss 19592680
nsv876769 CNV Loss 21882294
nsv470561 CNV Loss 18288195
nsv876770 CNV Loss 21882294
nsv523560 CNV Loss 19592680
dgv602n27 CNV Loss 19166990
dgv1456e1 CNV Complex 17122850
nsv834692 CNV Loss 17160897
nsv876771 CNV Loss 21882294

Variation tolerance for SEMA3F Gene

Residual Variation Intolerance Score: 8.74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.22; 62.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEMA3F Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEMA3F Gene

Disorders for SEMA3F Gene

MalaCards: The human disease database

(2) MalaCards diseases for SEMA3F Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
brachial plexus lesion
  • brachial plexus lesions nos
wallerian degeneration
  • wallerian degeneration of the pyramidal tract
- elite association

Relevant External Links for SEMA3F

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SEMA3F: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SEMA3F Gene

Publications for SEMA3F Gene

  1. Isolation of the human semaphorin III/F gene (SEMA3F) at chromosome 3p21, a region deleted in lung cancer. (PMID: 8786119) Xiang R.-H. … Naylor S.L. (Genomics 1996) 2 23 67
  2. Hormonal regulation and distinct functions of semaphorin-3B and semaphorin-3F in ovarian cancer. (PMID: 20124444) Joseph D. … Syed V. (Mol. Cancer Ther. 2010) 23 67
  3. Id2 promotes tumor cell migration and invasion through transcriptional repression of semaphorin 3F. (PMID: 20388805) Coma S. … Klagsbrun M. (Cancer Res. 2010) 23 67
  4. Candidate gene analysis of semaphorins in patients with Alzheimer's disease. (PMID: 19957197) Villa C. … Galimberti D. (Neurol. Sci. 2010) 23 67
  5. Furin processing of semaphorin 3F determines its anti-angiogenic activity by regulating direct binding and competition for neuropilin. (PMID: 20387901) Parker M.W. … Vander Kooi C.W. (Biochemistry 2010) 23 67

Products for SEMA3F Gene

Sources for SEMA3F Gene

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