Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SEMA3F Gene

protein-coding   GIFtS: 64
GCID: GC03P050167

Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain,...

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted,
(Semaphorin) 3F1 2
     SEMA-IV2
Sema IV1 2 3     SEMAK2
Sema III/F2 3     Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, 3F2
Semaphorin IV2 3     Semaphorin III/F2
SEMA42 5     semaphorin-3F2

External Ids:    HGNC: 107281   Entrez Gene: 64052   Ensembl: ENSG000000016177   OMIM: 6011245   UniProtKB: Q132753   

Export aliases for SEMA3F gene to outside databases

Previous GC identifers: GC03M049760 GC03M049931 GC03P050046 GC03P050151


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SEMA3F Gene:
The semaphorins are a family of proteins that are involved in signaling. All the family members have a secretion
signal, a 500-amino acid sema domain, and 16 conserved cysteine residues (Kolodkin et al., 1993 (PubMed
8269517)). Sequence comparisons have grouped the secreted semaphorins into 3 general classes, all of which also
have an immunoglobulin domain. The semaphorin III family, consisting of human semaphorin III (SEMA3A; MIM
603961), chicken collapsin, and mouse semaphorins A, D, and E, all have a basic domain at the C terminus. Chicken
collapsin contributes to path finding by axons during development by inhibiting extension of growth cones (Luo et
al., 1993 (PubMed 8402908)) through an interaction with a collapsin response mediator protein of relative
molecular mass 62K (CRMP62) (Goshima et al., 1995 (PubMed 7637782)), a putative homolog of an axonal guidance
associated UNC33 gene product (MIM 601168). SEMA3F is a secreted member of the semaphorin III family.(supplied by
OMIM, Mar 2008)

GeneCards Summary for SEMA3F Gene:
SEMA3F (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F) is a protein-coding gene. Diseases associated with SEMA3F include brachial plexus lesion, and wallerian degeneration. GO annotations related to this gene include chemorepellent activity and receptor activity. An important paralog of this gene is SEMA3C.

UniProtKB/Swiss-Prot: SEM3F_HUMAN, Q13275
Function: May play a role in cell motility and cell adhesion

Gene Wiki entry for SEMA3F Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEMA3F gene promoter:
         p53   Sox9   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEMA3F promoter sequence
   Search Chromatin IP Primers for SEMA3F

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEMA3F


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

SEMA3F Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA3F gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P050167:  view genomic region     (about GC identifiers)

Start:
50,192,478 bp from pter      End:
50,226,508 bp from pter
Size:
34,031 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SEM3F_HUMAN, Q13275 (See protein sequence)
Recommended Name: Semaphorin-3F precursor  
Size: 785 amino acids; 88381 Da
Developmental stage: Detected as early as embryonic day 10
Secondary accessions: C9JQ85 Q13274 Q13372 Q15704 Q6GTR4
Alternative splicing: 2 isoforms:  Q13275-1   Q13275-2   

Explore the universe of human proteins at neXtProt for SEMA3F: NX_Q13275

Explore proteomics data for SEMA3F at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn53, Asn126
  • Modification sites at PhosphoSitePlus

  • See SEMA3F Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004177.3  
    ENSEMBL proteins: 
     ENSP00000392588   ENSP00000398399   ENSP00000388931   ENSP00000002829   ENSP00000400549  
     ENSP00000409859   ENSP00000416356  

    SEMA3F Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SEMA3F
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SEMA3F
    GenScript Custom Purified and Recombinant Proteins Services for SEMA3F
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEMA3F

    SEMA3F Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SEMA3F
    R&D Systems Antibodies for SEMA3F (Semaphorin 3F)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SEMA3F
    Novus Biologicals SEMA3F Antibodies
    Abcam antibodies for SEMA3F
    Cloud-Clone Corp. Antibodies for SEMA3F
    ThermoFisher Antibodies for SEMA3F
    LSBio Antibodies in human, mouse, rat for SEMA3F

    SEMA3F Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SEMA3F
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SEMA3F
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SEMA3F
    Cloud-Clone Corp. CLIAs for SEMA3F


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    SEMA: Semaphorins

    Selected InterPro protein domains (see all 7):
     IPR013783 Ig-like_fold
     IPR027231 Semaphorin
     IPR001627 Semap_dom
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q13275

    ProtoNet protein and cluster: Q13275

    2 Blocks protein domains:
    IPB001627 Semaphorin/CD100 antigen
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: SEM3F_HUMAN, Q13275
    Similarity: Belongs to the semaphorin family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Sema domain


    SEMA3F for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEM3F_HUMAN, Q13275
    Function: May play a role in cell motility and cell adhesion

         Genatlas biochemistry entry for SEMA3F:
    semaphorin 3F,secreted,expressed in mammary gland,kidney,fetal brain,lung,repellent of the nerve growth cone
    guidance

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----
    GO:0045499chemorepellent activity IDA15814794
         
    SEMA3F for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SEMA3F:
     Increased cell elongation 

         3 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Sema3f):
     cellular  growth/size/body  nervous system 

    SEMA3F for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SEMA3F: Sema3ftm1Mom Sema3ftm1.2Ddg

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEMA3F
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SEMA3F

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEMA3F
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEMA3F

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SEMA3F using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEMA3F (see all 30):
    hsa-let-7d hsa-miR-429 hsa-miR-575 hsa-let-7c hsa-miR-486-3p hsa-let-7g hsa-miR-511 hsa-miR-661
    SwitchGear 3'UTR luciferase reporter plasmidSEMA3F 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SEMA3F
    Predesigned siRNA for gene silencing in human, mouse, rat SEMA3F

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SEMA3F

    Clone
    Products:
         
    OriGene clones in human, mouse for SEMA3F (see all 7)
    OriGene ORF clones in mouse, rat for SEMA3F
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEMA3F (NM_004186)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA3F
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA3F

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SEMA3F
    Browse ESI BIO Cell Lines and PureStem Progenitors for SEMA3F 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3F


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SEM3F_HUMAN, Q13275: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    plasma membrane2
    cytoskeleton1
    endoplasmic reticulum1
    lysosome1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS8786119
    GO:0016020membrane IEA--

    SEMA3F for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SEMA3F About    
    See pathways by source

    SuperPathContained pathways About
    1Selected targets of p53
    Selected targets of p53
    2Axon guidance
    Axon guidance

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for SEMA3F):
        Axon guidance


    SEMA3F for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEMA3F
    Interactions:

        GeneGlobe Interaction Network for SEMA3F

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for SEMA3F (Q132752, 3 ENSP000000028294) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC35G2Q8TBE72, 3, ENSP000003767944MINT-65449 I2D: score=4 STRING: ENSP00000376794
    NRP2O604623, ENSP000003535824I2D: score=3 STRING: ENSP00000353582
    NRP1O147863, ENSP000002653714I2D: score=1 STRING: ENSP00000265371
    VEGFAP156923, ENSP000003611254I2D: score=2 STRING: ENSP00000361125
    SHBGP042783, ENSP000003698164I2D: score=3 STRING: ENSP00000369816
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001755neural crest cell migration IEA--
    GO:0007275multicellular organismal development ----
    GO:0007411axon guidance IDA15814794
    GO:0021675nerve development ISS--
    GO:0048843negative regulation of axon extension involved in axon guidance IEA--

    SEMA3F for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEMA3F (SEM3F)

    1 Novoseek inferred chemical compound relationship for SEMA3F gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 64.6 19 12845630 (4), 15967098 (3), 15802023 (2), 14552889 (2) (see all 10)



    SEMA3F for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SEMA3F gene: 
    NM_004186.3  

    Unigene Cluster for SEMA3F:

    Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
    Hs.32981  [show with all ESTs]
    Unigene Representative Sequence: U38276
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000414301 ENST00000450338 ENST00000413852 ENST00000002829(uc003cyj.3)
    ENST00000426511 ENST00000434342(uc003cyk.3) ENST00000420831 ENST00000493743
    ENST00000470737

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SEMA3F using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEMA3F (see all 30):
    hsa-let-7d hsa-miR-429 hsa-miR-575 hsa-let-7c hsa-miR-486-3p hsa-let-7g hsa-miR-511 hsa-miR-661
    SwitchGear 3'UTR luciferase reporter plasmidSEMA3F 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SEMA3F
    Predesigned siRNA for gene silencing in human, mouse, rat SEMA3F
    Clone
    Products:
         
    OriGene clones in human, mouse for SEMA3F (see all 7)
    OriGene ORF clones in mouse, rat for SEMA3F
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEMA3F (NM_004186)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA3F
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA3F
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SEMA3F
    OriGene qSTAR qPCR primer pairs in human, mouse for SEMA3F
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEMA3F
      QuantiTect SYBR Green Assays in human, mouse, rat SEMA3F
      QuantiFast Probe-based Assays in human, mouse, rat SEMA3F

    Additional mRNA sequence: 

    AB209259.1 BC042914.1 U32171.1 U32172.1 U33920.1 U38276.1 

    8 DOTS entries:

    DT.70102963  DT.120922459  DT.120922443  DT.455193  DT.97807852  DT.120922358  DT.91924253  DT.91950783 

    Selected AceView cDNA sequences (see all 121):

    U32172 AI378926 BF222030 AW328572 BE907428 BM889483 BF058597 AI049495 
    CB240860 AW328571 BM725255 BE017963 U32171 CA489866 AI127293 AI186895 
    BM679905 AI657144 AW083225 BF589243 BM718752 BV180305 AW177770 BU622928 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SEMA3F (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
    SP1:                                                                                                  -                                                   
    SP2:              -     -     -                             -                                         -                                                   
    SP3:                                                        -                                         -                                                   
    SP4:              -     -                                   -                                                                                             
    SP5:                                                                                                  -           -                                       


    ECgene alternative splicing isoforms for SEMA3F

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SEMA3F expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGCGAGGA
    SEMA3F Expression
    About this image


    SEMA3F expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
     
     Tooth (Integumentary System)    fully expand to see all 6 entries
             Inner Enamel Epithelial Cells Dental Enamel
     
     Epithelial Cells
             Inner Enamel Epithelial Cells Dental Enamel
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
    SEMA3F Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEMA3F Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.32981

    UniProtKB/Swiss-Prot: SEM3F_HUMAN, Q13275
    Tissue specificity: Expressed abundantly but differentially in a variety of neural and nonneural tissues. There is
    high expression in mammary gland, kidney, fetal brain, and lung and lower expression in heart and liver

        Custom PCR Arrays for SEMA3F
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SEMA3F
    OriGene qSTAR qPCR primer pairs in human, mouse for SEMA3F
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEMA3F
    QuantiTect SYBR Green Assays in human, mouse, rat SEMA3F
    QuantiFast Probe-based Assays in human, mouse, rat SEMA3F
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3F

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for SEMA3F gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sema3f1 , 5 sema domain, immunoglobulin domain (Ig), short basic more1, 5 88.95(n)1
    96.42(a)1
      9 (58.91 cM)5
    203501  NM_011349.31  NP_035479.21 
     1076815025 
    chicken
    (Gallus gallus)
    Aves SEMA3F1 sema domain, immunoglobulin domain (Ig), short basic more 78.27(n)
    82.33(a)
      374109  NM_204258.1  NP_989589.1 
    lizard
    (Anolis carolinensis)
    Reptilia SEMA3F6
    sema domain, immunoglobulin domain (Ig), short bas...
    76(a)
    1 ↔ 1
    2(148600633-148655010)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC688702 hypothetical protein MGC68870 71.19(n)    BC057717.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sema3fb1 semaphorin 3fb 67.4(n)
    70.96(a)
      799945  XM_001921071.4  XP_001921106.2 


    ENSEMBL Gene Tree for SEMA3F (if available)
    TreeFam Gene Tree for SEMA3F (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SEMA3F gene
    SEMA3C2  SEMA4F2  SEMA3E2  SEMA4B2  SEMA4C2  SEMA4A2  SEMA4D2  SEMA4G2  
    SEMA3A2  SEMA3G2  SEMA3D2  
    18 SIMAP similar genes for SEMA3F using alignment to 6 protein entries:     SEM3F_HUMAN (see all proteins):
    SEMA3C    SEMA3A    SEMA3E    SEMA3D    SEMA3B    SEMA3G
    SEMA4A    SEMA4B    SEMA6C    SEMA4D    SEMA5A    SEMA5B
    SEMA6D    SEMA4C    DKFZp686D04248    SEMA4G    SEMA4D variant protein    SEMA7A

    SEMA3F for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SEMA3F (see all 524)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1412026141,2
    --50195749(+) CACAGA/GGGGTA 1 -- int10--------
    rs1439399681,2
    --50195970(+) GCCAAA/CTCCCA 1 -- int10--------
    rs7566461,2
    C--50196252(-) CCCCAT/CAGCCC 1 -- int14Minor allele frequency- C:0.00NA MN 208
    rs26248421,2
    C,F,O,H--50196418(-) CACTTT/GTACTA 1 -- int1106Minor allele frequency- G:0.14NS EA PA EU CA WA NA CSA 6259
    rs1843376171,2
    --50196445(+) GCCTTA/TCCTTT 1 -- int10--------
    rs730809801,2
    C,F--50196533(+) TCTACC/TGTAAT 1 -- int13Minor allele frequency- T:0.17WA NA EA 358
    rs1468766441,2
    --50196570(+) GGAGAA/CGACCT 1 -- int10--------
    rs20720541,2
    C,F,H--50196623(-) CCACCT/CGGAGG 1 -- int120Minor allele frequency- C:0.33EA NS NA WA 3786
    rs1489944941,2
    --50196804(+) CTGGTA/GACCCC 1 -- int10--------
    rs1437677531,2
    --50196806(+) GGTGAC/GCCCAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for SEMA3F (50192478 - 50226508 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SEMA3F (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876771CNV Loss21882294
    nsv523662CNV Loss19592680
    nsv876770CNV Loss21882294
    nsv834692CNV Loss17160897
    nsv876769CNV Loss21882294
    dgv602n27CNV Loss19166990
    nsv515986CNV Loss19592680
    nsv470561CNV Loss18288195
    nsv834690CNV Loss17160897
    nsv523560CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEMA3F
    DNA2.0 Custom Variant and Variant Library Synthesis for SEMA3F

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601124    OMIM disorders: --

    Selected diseases for SEMA3F (see all 21):    
    About MalaCards
    brachial plexus lesion    wallerian degeneration    soft tissue sarcoma    neuroma
    lung cancer    nasopharyngitis    myocardial infarction    sarcoma
    melanoma    hypoxia    ovarian cancer    arthritis
    rheumatoid arthritis    alzheimer's disease    breast cancer    endotheliitis
    hypertension    prostate cancer    prostatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for SEMA3F:
    Brachial plexus lesion

    SEMA3F for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    8 Novoseek inferred disease relationships for SEMA3F gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    small cell lung cancer 50.8 3 15569615 (1), 8633026 (1), 11980661 (1)
    cancer lung 41.6 22 19177200 (5), 15967098 (4), 14659031 (2), 12845630 (2) (see all 9)
    tumors 29.9 34 20388805 (4), 15520858 (4), 15802023 (2), 12613547 (2) (see all 17)
    primary tumor 3.24 2 15802023 (1)
    metastasis 1.11 7 20388805 (2), 15520858 (2)
    breast cancer 0 2 15802023 (1), 15985208 (1)
    melanoma 0 2 16691189 (1), 15520858 (1)
    cancer 0 3 19177200 (2), 17520683 (1)

    Genetic Association Database (GAD): SEMA3F
    Human Genome Epidemiology (HuGE) Navigator: SEMA3F (4 documents)

    Export disorders for SEMA3F gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SEMA3F gene, integrated from 10 sources (see all 91):
    (articles sorted by number of sources associating them with SEMA3F)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of the human semaphorin III/F gene (SEMA3F) at chromosome 3p21, a region deleted in lung cancer. (PubMed id 8786119)1, 2, 3, 9 Xiang R.-H....Naylor S.L. (Genomics 1996)
    2. Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin. (PubMed id 8649831)1, 2, 3 Roche J....Drabkin H. (Oncogene 1996)
    3. Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns. (PubMed id 8633026)1, 2, 9 Sekido Y.... Minna J.D. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    4. Association of genetic variants with myocardial infarction in Japanese individuals with different lipid profiles. (PubMed id 20198310)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    5. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    6. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    7. Semaphorin 3B and 3F single nucleotide polymorphisms are associated with prostate cancer risk and poor prognosis. (PubMed id 19683737)1, 4 Beuten J....Naylor S.L. (J. Urol. 2009)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Id2 promotes tumor cell migration and invasion through transcriptional repression of semaphorin 3F. (PubMed id 20388805)1, 9 Coma S....Klagsbrun M. (Cancer Res. 2010)
    10. ZEB-1, a repressor of the semaphorin 3F tumor suppressor gene in lung cancer cells. (PubMed id 19177200)1, 9 Clarhaut J....Roche J. (Neoplasia 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6405 HGNC: 10728 AceView: SEMA3F Ensembl:ENSG00000001617 euGenes: HUgn6405
    ECgene: SEMA3F Kegg: 6405 H-InvDB: SEMA3F

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SEMA3F Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SEMA3F Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SEMA3F gene:
    Search GeneIP for patents involving SEMA3F

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SEMA3F
     
     EMD Millipore genomic analysis products

      
     Antibodies for SEMA3F (Semaphorin 3F)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SEMA3F  
     OriGene qPCR primer pairs and template standards for SEMA3F   OriGene Protein Over-expression Lysate for SEMA3F  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SEMA3F  
     OriGene qSTAR qPCR primer pairs in human, mouse for SEMA3F   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SEMA3F   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SEMA3F   OriGene Custom Protein Services for SEMA3F  

     
     
     Block miRNA regulation of human, mouse, rat SEMA3F using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SEMA3F
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEMA3F Predesigned siRNA for gene silencing in human, mouse, rat SEMA3F
     QuantiFast Probe-based Assays in human, mouse, rat SEMA3F QuantiTect SYBR Green Assays in human, mouse, rat SEMA3F
     Custom PCR Arrays for SEMA3F Search Chromatin IP Primers for SEMA3F
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEMA3F  GeneGlobe Interaction Network for SEMA3F
     Regulatory tfbs in SEMA3F promoter
     GenScript Custom Purified and Recombinant Proteins Services for SEMA3F GenScript cDNA clones with any tag delivered in your preferred vector for SEMA3F
     GenScript Custom Assay Services for SEMA3F GenScript Custom overexpressing Cell Line Services for SEMA3F
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SEMA3F (SEM3F)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SEMA3F antibodies
     Antibodies for SEMA3F
     See all of Abcam's Antibodies, Kits and Proteins for SEMA3F
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SEMA3F
     Antibodies for SEMA3F
     ELISAs for SEMA3F
     CLIAs for SEMA3F



     Browse ESI BIO Cell Lines and PureStem Progenitors for SEMA3F
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3F
     SwitchGear 3'UTR luciferase reporter plasmids for SEMA3F
     SwitchGear Promoter luciferase reporter plasmids for SEMA3F
     ThermoFisher Antibodies for SEMA3F
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA3F
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEMA3F
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SEMA3F
     LSBio Antibodies in human, mouse, rat for SEMA3F
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SEMA3F gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4