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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEMA3F Gene

protein-coding   GIFtS: 62
GCID: GC03P050167

sema domain, immunoglobulin domain (Ig), short basic domain,...
 Explore 20 diseases affiliated with
SEMA3F via
MalaCards
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 Human Malady Compendium 
Biological research products
for SEMA3F    

Aliases
for SEMA3F gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted,
(Semaphorin) 3F1 2
     Sema41
SEMAK1 2     SEMA-IV2
Sema III/F2 3     Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, 3F2
Sema IV2 3     Semaphorin III/F2
Semaphorin IV2 3     Semaphorin-3F1
SEMA42 5     

External Ids:    HGNC: 107281   Entrez Gene: 64052   Ensembl: ENSG000000016177   OMIM: 6011245   UniProtKB: Q132753   

Export aliases for SEMA3F gene to outside databases

Previous GC identifers: GC03M049760 GC03M049931 GC03P050046 GC03P050151


Summaries
for SEMA3F gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SEMA3F:
The semaphorins are a family of proteins that are involved in signaling. All the family members have a secretion
signal, a 500-amino acid sema domain, and 16 conserved cysteine residues (Kolodkin et al., 1993 (PubMed 8269517)).
Sequence comparisons have grouped the secreted semaphorins into 3 general classes, all of which also have an
immunoglobulin domain. The semaphorin III family, consisting of human semaphorin III (SEMA3A; MIM 603961), chicken
collapsin, and mouse semaphorins A, D, and E, all have a basic domain at the C terminus. Chicken collapsin contributes
to path finding by axons during development by inhibiting extension of growth cones (Luo et al., 1993 (PubMed
8402908)) through an interaction with a collapsin response mediator protein of relative molecular mass 62K (CRMP62)
(Goshima et al., 1995 (PubMed 7637782)), a putative homolog of an axonal guidance associated UNC33 gene product (MIM
601168). SEMA3F is a secreted member of the semaphorin III family.(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: SEM3F_HUMAN, Q13275
Function: May play a role in cell motility and cell adhesion

Gene Wiki entry for SEMA3F


Genomic Views
for SEMA3F gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEMA3F gene promoter:
         p53   Sox9   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SEMA3F promoter sequence
   Search SABiosciences Chromatin IP Primers for SEMA3F

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA3F


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

SEMA3F Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA3F gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P050167:  view genomic region     (about GC identifiers)

Start:
 50,192,478 bp from pter      End:
 50,226,508 bp from pter
Size:
 34,031 bases      Orientation:
 plus strand

Proteins
for SEMA3F gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SEM3F_HUMAN, Q13275 (See protein sequence)
Recommended Name: Semaphorin-3F precursor  
Size: 785 amino acids; 88381 Da
Subcellular location: Secreted (By similarity)
Developmental stage: Detected as early as embryonic day 10
Secondary accessions: Q13274 Q13372 Q15704 Q6GTR4

Explore the universe of human proteins at neXtProt for SEMA3F: NX_Q13275

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13275

    • SEMA3F Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004177.3  
    ENSEMBL proteins: 
     ENSP00000392588   ENSP00000398399   ENSP00000388931   ENSP00000002829   ENSP00000400549  
     ENSP00000409859   ENSP00000416356  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: SEMA3F
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    Uscn Proteins for SEMA3F

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS8786119
    GO:0016020membrane IEA--


    SEMA3F for ontologies           About GeneDecksing



    SEMA3F Antibody Products: 
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    Uscn Antibodies for SEMA3F
    Search ThermoFisher Antibodies for SEMA3F

    Assay Products for SEMA3F: 
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    Uscn ELISAs and CLIAs for SEMA3F

    Protein Domains /
    Families
    for SEMA3F gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SEMA3F for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR007110 Ig-like_dom
     IPR003659 Plexin-like
     IPR003599 Ig_sub
     IPR016201 Plexin-like_fold
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q13275

    ProtoNet protein and cluster: Q13275

    2 Blocks protein families:
    IPB001627 Semaphorin/CD100 antigen
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: SEM3F_HUMAN, Q13275
    Similarity: Belongs to the semaphorin family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Sema domain


    Function
    for SEMA3F gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SEM3F_HUMAN, Q13275
    Function: May play a role in cell motility and cell adhesion

         Genatlas biochemistry entry for SEMA3F:
    semaphorin 3F,secreted,expressed in mammary gland,kidney,fetal brain,lung,repellent of the nerve growth cone guidance

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA3F
    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA3F (see all 30):
    hsa-let-7d hsa-miR-429 hsa-miR-575 hsa-let-7c hsa-miR-486-3p hsa-let-7g hsa-miR-511 hsa-miR-661
    SwitchGear 3'UTR luciferase reporter plasmid: SEMA3F 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA3F (see all 7)
    OriGene shRNA RFP: SEMA3F
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA3F

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA3F (see all 3)
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    Cell Line
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    Search LifeMap BioReagents cell lines for SEMA3F

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3F

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0045499chemorepellent activity IDA15814794


    SEMA3F for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SEMA3F:
     Increased cell elongation 

    Animal Models:
         Mouse knock-outs for SEMA3F: Sema3ftm1Mom Sema3ftm1.2Ddg
         3 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Sema3f):
     cellular  growth/size  nervous system 

    SEMA3F for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SEMA3F gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Selected targets of p53
    		Selected targets of p531.00
    2Axon guidance
    		Axon guidance1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for SEMA3F
        Selected targets of p53



    1         Kegg Pathway  (Kegg details for SEMA3F):
        Axon guidance


    SEMA3F for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SEMA3F

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/9 Interacting proteins for SEMA3F (Q132752, 3 ENSP000000028294) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC35G2Q8TBE72, 3, ENSP000003767944MINT-65449 I2D: score=4 STRING: ENSP00000376794
    NRP2O604623, ENSP000003535824I2D: score=3 STRING: ENSP00000353582
    NRP1O147863, ENSP000002653714I2D: score=1 STRING: ENSP00000265371
    VEGFAP156923, ENSP000003611254I2D: score=2 STRING: ENSP00000361125
    SHBGP042783, ENSP000003698164I2D: score=3 STRING: ENSP00000369816
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001755neural crest cell migration IEA--
    GO:0007275multicellular organismal development ----
    GO:0007411axon guidance IDA15814794
    GO:0048843negative regulation of axon extension involved in axon guidance IEA--
    GO:0050919negative chemotaxis ----


    SEMA3F for ontologies           About GeneDecksing



    Drugs & Compounds
    for SEMA3F gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SEMA3F for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEMA3F
    1 Novoseek chemical compound relationship for SEMA3F gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 64.6 19 12845630 (4), 15967098 (3), 15802023 (2), 14552889 (2) (see all 10)

    Search CenterWatch for drugs/clinical trials and news about SEMA3F / SEM3F 

    Transcripts
    for SEMA3F gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SEMA3F gene: 
    NM_004186.3  

    Unigene Cluster for SEMA3F:

    Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
    Hs.32981  [show with all ESTs]
    Unigene Representative Sequence: U38276
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000414301 ENST00000450338 ENST00000413852 ENST00000002829(uc003cyj.3)
    ENST00000426511 ENST00000434342(uc003cyk.3) ENST00000420831 ENST00000493743
    ENST00000470737

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA3F
    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA3F (see all 30):
    hsa-let-7d hsa-miR-429 hsa-miR-575 hsa-let-7c hsa-miR-486-3p hsa-let-7g hsa-miR-511 hsa-miR-661
    SwitchGear 3'UTR luciferase reporter plasmid: SEMA3F 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA3F (see all 7)
    OriGene shRNA RFP: SEMA3F
    OriGene siRNA: SEMA3F
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA3F
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA3F
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA3F

    Additional cDNA sequence: 

    AB209259.1 BC042914.1 U32171.1 U32172.1 U33920.1 U38276.1 

    8 DOTS entries:

    DT.70102963  DT.120922459  DT.120922443  DT.455193  DT.97807852  DT.120922358  DT.91924253  DT.91950783 

    24/121 AceView cDNA sequences (see all 121):

    CB240860 BE017963 AW328571 U32171 AI049495 BM725255 BF058597 BE907428 
    AW328572 BF222030 AI378926 U32172 BM889483 CA489866 AW081180 AW271352 
    BV203017 BM681148 BU741943 BX092687 AA454570 AW272721 BM918793 AW514477 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SEMA3F (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
    SP1:                                                                                                  -                                                   
    SP2:              -     -     -                             -                                         -                                                   
    SP3:                                                        -                                         -                                                   
    SP4:              -     -                                   -                                                                                             
    SP5:                                                                                                  -           -                                       


    ECgene alternative splicing isoforms for SEMA3F

    Expression
    for SEMA3F gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEMA3F expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GATGCGAGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SEMA3F expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PancreasDorsal Pancreatic BudImmature Beta Progenitor CellsPancreas
    PancreasVentral Pancreatic BudImmature Beta Progenitor CellsPancreas
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Dorsal ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)

    See SEMA3F Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEMA3F

    SOURCE GeneReport for Unigene cluster: Hs.32981

    UniProtKB/Swiss-Prot: SEM3F_HUMAN, Q13275
    Tissue specificity: Expressed abundantly but differentially in a variety of neural and nonneural tissues. There is high
    expression in mammary gland, kidney, fetal brain, and lung and lower expression in heart and liver

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    In Situ
    Assay Products:     
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    Orthologs
    for SEMA3F gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SEMA3F gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SEMA3F1 sema domain, immunoglobulin domain (Ig), short basic more 77.98(n)
    82.02(a)    		   374109  NM_204258.1  NP_989589.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SEMA3F6
    		 --
    		 76(a)
    		 1 ↔ 1
    		 2(148600633-148650486)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC688702 hypothetical protein MGC68870 71.19(n)    BC057717.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii sema3fb1 semaphorin 3fb 68.64(n)
    72.62(a)    		   799945  XM_001921071.3  XP_001921106.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Sema-2a6
    Sema-2b6
    		 Semaphorin-2b
    		 25(a)
    24(a)
    		 possible ortholog
    possible ortholog
    		 2R(12387701-12420934)
    2R(12274029-12319263)
    worm
    (Caenorhabditis elegans)    		 Secernentea mab-206
    smp-26
    		 SeMaPhorin related family member (smp-2)
    		 20(a)
    18(a)
    		 possible ortholog
    possible ortholog
    		 I(1644590-1651382)
    I(3667127-3671705)


    ENSEMBL Gene Tree for SEMA3F (if available)
    TreeFam Gene Tree for SEMA3F (if available) 

    Paralogs
    for SEMA3F gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEMA3F gene
    SEMA3C2  SEMA4F2  SEMA3E2  SEMA4B2  SEMA4C2  SEMA4A2  SEMA4G2  SEMA4D2  
    SEMA3A2  SEMA3G2  SEMA3D2  
    18 SIMAP similar genes for SEMA3F using alignment to 7 protein entries:     SEM3F_HUMAN (see all proteins):
    SEMA3C    SEMA3A    SEMA3E    SEMA3D    SEMA3B    SEMA3G
    SEMA4B    SEMA4A    SEMA4D    SEMA5A    SEMA6C    SEMA5B
    SEMA6D    SEMA4C    SEMA4D variant protein    DKFZp686D04248    SEMA4G    SEMA7A

    SEMA3F for paralogs           About GeneDecksing



    Genomic Variants
    for SEMA3F gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/461 NCBI SNPs in SEMA3F are shown (see all 461)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1386323011,2
    		--50190855(+) CAGGCC/TATAAG 2 -- int1 us2k10--------
    rs1429252961,2
    		--50190948(+) GGTGCA/GGTGGT 2 -- int1 us2k10--------
    rs1397073111,2
    		--50191045(+) GGGAGA/CGGTGC 2 -- int1 us2k10--------
    rs25263921,2
    		C,F,H,--50191191(-) GTGCAA/GGGTGG 2 -- us2k1 int131Minor allele frequency- N:0.00NS EA NA WA CSA 2978
    rs1918643101,2
    		--50191287(+) GAAGGC/TGGAGA 2 -- int1 us2k10--------
    rs1838939551,2
    		--50191466(+) GGAAAA/GGAGGG 2 -- int1 us2k10--------
    rs1426157271,2
    		--50191639(+) TGCCCA/GGGGCA 2 -- us2k1 int10--------
    rs1505501281,2
    		--50191961(+) GGCTGA/GAGGCT 2 -- int1 us2k10--------
    rs25263901,2
    		C,F,--50192760(-) GGGGCG/ACTCGG 2 -- int1 us2k11Minor allele frequency- A:0.36NA 120
    rs25263891,2
    		C,F,--50192826(-) TCCGCG/AGGCTT 2 -- us2k1 int13Minor allele frequency- A:0.50NA 124

    HapMap Linkage Disequilibrium report for SEMA3F (50192478 - 50226508 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for SEMA3F
         7 CNVs: 4335 3429 53228 51108 30175 51107 51112

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEMA3F
    DNA2.0 Custom Variant and Variant Library Synthesis for SEMA3F

    Disorders / Diseases
    for SEMA3F gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SEMA3F for disorders           About GeneDecksing

    OMIM gene information: 601124    OMIM disorders: --

    20 diseases for SEMA3F:    About MalaCards
    brachial plexus lesion    soft tissue sarcoma    wallerian degeneration    myocardial infarction
    neuroma    rheumatoid arthritis    paralysis    lung cancer
    breast cancer    sarcoma    alzheimer's disease    arthritis
    ovarian cancer    nasopharyngitis    melanoma    prostate cancer
    hypoxia    prostatitis    neuronitis    carcinoma

    1 disease from the University of Copenhagen DISEASES database for SEMA3F:
    Brachial plexus lesion

    8 Novoseek disease relationships for SEMA3F gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    small cell lung cancer 50.8 3 15569615 (1), 8633026 (1), 11980661 (1)
    cancer lung 41.6 22 19177200 (5), 15967098 (4), 14659031 (2), 12845630 (2) (see all 9)
    tumors 29.9 34 20388805 (4), 15520858 (4), 15802023 (2), 12613547 (2) (see all 17)
    primary tumor 3.24 2 15802023 (1)
    metastasis 1.11 7 20388805 (2), 15520858 (2)
    breast cancer 0 2 15802023 (1), 15985208 (1)
    melanoma 0 2 16691189 (1), 15520858 (1)
    cancer 0 3 19177200 (2), 17520683 (1)

    Human Genome Epidemiology (HuGE) Navigator: SEMA3F (4 documents)

    Export disorders for SEMA3F gene to outside databases

    Publications
    for SEMA3F gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEMA3F gene, integrated from 9 sources (see all 85):
    (articles sorted by number of sources associating them with SEMA3F)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of the human semaphorin III/F gene (SEMA3F) at chromosome 3p21, a region deleted in lung cancer. (PubMed id 8786119)1, 2, 3, 9 Xiang R.-H....Naylor S.L. (1996)
    2. Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin. (PubMed id 8649831)1, 2, 3 Roche J....Drabkin H. (1996)
    3. Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns. (PubMed id 8633026)1, 2, 9 Sekido Y.... Minna J.D. (1996)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Id2 promotes tumor cell migration and invasion throug h transcriptional repression of semaphorin 3F. (PubMed id 20388805)1, 9 Coma S....Klagsbrun M. (2010)
    6. ZEB-1, a repressor of the semaphorin 3F tumor suppressor gene in lung cancer cells. (PubMed id 19177200)1, 9 Clarhaut J....Roche J. (2009)
    7. Hormonal regulation and distinct functions of semapho rin-3B and semaphorin-3F in ovarian cancer. (PubMed id 20124444)1, 9 Joseph D....Syed V. (2010)
    8. Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype. (PubMed id 15520858)1, 9 Bielenberg D.R....Klagsbrun M. (2004)
    9. Selective suppression of in vivo tumorigenicity by semaphorin SEMA3F in lung cancer cells. (PubMed id 15967098)1, 9 Kusy S....Roche J. (2005)
    10. Semaphorin-3A and semaphorin-3F work together to repel endothelial cells and to inhibit their survival by induction of apoptosis. (PubMed id 17569671)1, 9 Guttmann-Raviv N....Neufeld G. (2007)

    External Searches for SEMA3F gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing SEMA3F gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6405 HGNC: 10728 AceView: SEMA3F Ensembl:ENSG00000001617 euGenes: HUgn6405
    ECgene: SEMA3F Kegg: 6405 H-InvDB: SEMA3F

    Other Databases showing SEMA3F gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SEMA3F gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEMA3F Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SEMA3F Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SEMA3F gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SEMA3F gene:
    Search GeneIP for patents involving SEMA3F

    GeneCards and IP:
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