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SEMA3E Gene

protein-coding   GIFtS: 62
GCID: GC07M082993

Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain,...


(Previous symbol: SEMAH)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted,
(Semaphorin) 3E1 2
     M-SEMAH2
SEMAH1 2 3 5     M-SemaK2
KIAA03313 5     coll-52
M-Sema H1     semaphorin-3E2

External Ids:    HGNC: 107271   Entrez Gene: 97232   Ensembl: ENSG000001703817   OMIM: 6081665   UniProtKB: O150413   

Export aliases for SEMA3E gene to outside databases

Previous GC identifers: GC07M081528 GC07M082591 GC07M082605 GC07M082637 GC07M082831 GC07M077595


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SEMA3E Gene:
Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin
(Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular
portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates
contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon
guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene
encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding
different isoforms have been found for this gene.(provided by RefSeq, May 2010)

GeneCards Summary for SEMA3E Gene:
SEMA3E (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E) is a protein-coding gene. Diseases associated with SEMA3E include ischemic retinopathy, and charge syndrome. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA3C.

UniProtKB/Swiss-Prot: SEM3E_HUMAN, O15041
Function: Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of
the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and
inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during
embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning
during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEMA3E gene promoter:
         STAT1   Pbx1a   Brachyury   STAT1beta   CUTL1   Evi-1   STAT1alpha   HEN1   STAT2   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SEMA3E promoter sequence
   Search Chromatin IP Primers for SEMA3E

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEMA3E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.11   Ensembl cytogenetic band:  7q21.11   HGNC cytogenetic band: 7q21.11

SEMA3E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA3E gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M082993:  view genomic region     (about GC identifiers)

Start:
82,993,222 bp from pter      End:
83,278,479 bp from pter
Size:
285,258 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 82,325,430-82,610,645     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SEM3E_HUMAN, O15041 (See protein sequence)
Recommended Name: Semaphorin-3E precursor  
Size: 775 amino acids; 89228 Da
Subunit: Interacts with PLXND1 (By similarity)
Sequence caution: Sequence=BAA20789.2; Type=Erroneous initiation;
Secondary accessions: B4E1P1 Q75M94 Q75M97
Alternative splicing: 2 isoforms:  O15041-1   O15041-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEMA3E: NX_O15041

Explore proteomics data for SEMA3E at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn44, Asn126, Asn330, Asn595, Asn596

  • See SEMA3E Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171600.1  NP_036563.1  

    ENSEMBL proteins: 
     ENSP00000303212   ENSP00000405052   ENSP00000412867   ENSP00000415184  
    Reactome Protein details: O15041

    SEMA3E Human Recombinant Protein Products:

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    Novus Biologicals SEMA3E Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for SEMA3E

    SEMA3E Antibody Products:

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    SEMA3E Assay Products:

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    Cloud-Clone Corp. CLIAs for SEMA3E


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    SEMA: Semaphorins

    Selected InterPro protein domains (see all 8):
     IPR015513 Semaphorin_3E
     IPR027231 Semaphorin
     IPR001627 Semap_dom
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry O15041

    ProtoNet protein and cluster: O15041

    2 Blocks protein domains:
    IPB001627 Semaphorin/CD100 antigen
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: SEM3E_HUMAN, O15041
    Similarity: Belongs to the semaphorin family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Sema domain


    SEMA3E for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEM3E_HUMAN, O15041
    Function: Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of
    the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and
    inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during
    embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning
    during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity)

         Summary: 

    During embryonic development, SEMA3E as signaling molecule affects the following cells:
    Endothelium: Endothelial Tip Cells (Arteries)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding IPI17318185
         
    SEMA3E for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Sema3e):
     behavior/neurological  cardiovascular system  embryogenesis  nervous system  vision/eye 

    SEMA3E for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEMA3E
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEMA3E
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEMA3E

    miRNA
    Products:
        
    miRTarBase miRNAs that target SEMA3E:
    hsa-mir-615-3p (MIRT040087)

    Block miRNA regulation of human, mouse, rat SEMA3E using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEMA3E (see all 17):
    hsa-miR-16-2* hsa-miR-520d-5p hsa-miR-3692 hsa-miR-515-5p hsa-miR-3161 hsa-miR-629* hsa-miR-1252 hsa-miR-140-3p
    SwitchGear 3'UTR luciferase reporter plasmidSEMA3E 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SEMA3E
    Predesigned siRNA for gene silencing in human, mouse, rat SEMA3E

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for SEMA3E
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SEMA3E (NM_012431)
    Sino Biological Human cDNA Clone for SEMA3E
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA3E
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA3E

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SEMA3E
    Browse ESI BIO Cell Lines and PureStem Progenitors for SEMA3E 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3E


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SEM3E_HUMAN, O15041: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    cytoskeleton1
    cytosol1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space TAS9515811
    GO:0016020membrane IEA--

    SEMA3E for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SEMA3E About    
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    2Semaphorin interactions
    Semaphorin interactions0.43
    Other semaphorin interactions0.00
    3Axon guidance
    Axon guidance

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for SEMA3E
        Other semaphorin interactions


    1 Kegg Pathway  (Kegg details for SEMA3E):
        Axon guidance


    SEMA3E for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEMA3E
    Interactions:

        Search GeneGlobe Interaction Network for SEMA3E

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for SEMA3E (O150411, 2, 3 ENSP000003032124) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLXND1Q9Y4D71, 2, 3, ENSP000003171284EBI-7283693,EBI-310731 MINT-4507932 MINT-4507966 I2D: score=1 STRING: ENSP00000317128
    PIP5K1BENSP000002653824STRING: ENSP00000265382
    RRASENSP000002467924STRING: ENSP00000246792
    NRP1ENSP000002653714STRING: ENSP00000265371
    SHBGENSP000003698164STRING: ENSP00000369816
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001569patterning of blood vessels ISS--
    GO:0001953negative regulation of cell-matrix adhesion ISS--
    GO:0002040sprouting angiogenesis ISS--
    GO:0007275multicellular organismal development ----
    GO:0007411axon guidance TAS--

    SEMA3E for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEMA3E (SEM3E)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SEMA3E gene (2 alternative transcripts): 
    NM_001178129.1  NM_012431.2  

    Unigene Cluster for SEMA3E:

    Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
    Hs.528721  [show with all ESTs]
    Unigene Representative Sequence: NM_012431
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307792(uc022agy.1 uc003uhy.2) ENST00000427262 ENST00000442159
    ENST00000453333
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SEMA3E using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEMA3E (see all 17):
    hsa-miR-16-2* hsa-miR-520d-5p hsa-miR-3692 hsa-miR-515-5p hsa-miR-3161 hsa-miR-629* hsa-miR-1252 hsa-miR-140-3p
    SwitchGear 3'UTR luciferase reporter plasmidSEMA3E 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SEMA3E
    Predesigned siRNA for gene silencing in human, mouse, rat SEMA3E
    Clone
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    OriGene ORF clones in mouse, rat for SEMA3E
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SEMA3E (NM_012431)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA3E
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA3E
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SEMA3E
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEMA3E
      QuantiTect SYBR Green Assays in human, mouse, rat SEMA3E
      QuantiFast Probe-based Assays in human, mouse, rat SEMA3E

    Additional mRNA sequence: 

    AB002329.1 AK297209.1 AK303925.1 BC140706.1 BC144338.1 BC152458.1 

    3 DOTS entries:

    DT.40121024  DT.121094472  DT.121094475 

    Selected AceView cDNA sequences (see all 31):

    CD678104 AB002329 AI962050 AW242470 AW450461 BX641613 BM554988 BM764313 
    BM804054 R85744 BG184444 CD676931 AI917271 CD671910 BM840320 BV188459 
    CA488964 BF665578 AI720166 D81222 BG215143 BQ184075 BG899759 AU127450 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SEMA3E expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATGCAGC
    SEMA3E Expression
    About this image


    SEMA3E expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Epithelial Cells
             Outer Root Sheath Cells Outer Root Sheath
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Definitive endoderm-like cells
     
     Hair (Integumentary System)    fully expand to see all 2 entries
             Bulge Stem Cells Bulge
     
     Kidney (Urinary System)
             Podocytes Podocyte Layer
     
     Epiblast (Early Embryonic Tissues)
             Epiblast-like cells
    SEMA3E Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEMA3E Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.528721
        Custom PCR Arrays for SEMA3E
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SEMA3E
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    QuantiFast Probe-based Assays in human, mouse, rat SEMA3E
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3E

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SEMA3E gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sema3e1 , 5 sema domain, immunoglobulin domain (Ig), short basic more1, 5 85.16(n)1
    90.19(a)1
      5 (5.66 cM)5
    203491  NM_011348.21  NP_035478.21 
     140252765 
    chicken
    (Gallus gallus)
    Aves SEMA3E1 sema domain, immunoglobulin domain (Ig), short basic more 77.63(n)
    81.55(a)
      374089  NM_204242.1  NP_989573.1 
    lizard
    (Anolis carolinensis)
    Reptilia SEMA3E6
    sema domain, immunoglobulin domain (Ig), short bas...
    82(a)
    1 ↔ 1
    5(87499162-87709704)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sema3e1 sema domain, immunoglobulin domain (Ig), short basic more 73.78(n)
    76.27(a)
      100494277  XM_002935256.2  XP_002935302.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sema3e1 sema domain, immunoglobulin domain (Ig), short basic more 62.4(n)
    60.97(a)
      565658  NM_001045084.1  NP_001038549.1 


    ENSEMBL Gene Tree for SEMA3E (if available)
    TreeFam Gene Tree for SEMA3E (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SEMA3E gene
    SEMA3C2  SEMA4F2  SEMA4B2  SEMA4C2  SEMA3F2  SEMA4A2  SEMA4D2  SEMA4G2  
    SEMA3A2  SEMA3G2  SEMA3D2  
    13 SIMAP similar genes for SEMA3E using alignment to 3 protein entries:     SEM3E_HUMAN (see all proteins):
    SEMA3A    SEMA3D    SEMA3C    SEMA3F    SEMA3G    SEMA3B
    SEMA4G    SEMA4F    SEMA4B    SEMA4C    SEMA4D    SEMA4D variant protein
    SEMA6D

    SEMA3E for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SEMA3E
    PGOHUM00000237128


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SEMA3E (see all 6494)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1398552531,2
    C--82325396(+) GTCAA-/TTCATTT
    TTTTTTTTT
    TTTTT
    2 -- ds50010--------
    rs1869231441,2
    --82351059(+) CAGTAG/TACATA 2 -- int10--------
    rs132261001,2
    C,A--82351076(+) TACACG/ACATAT 2 -- int15Minor allele frequency- A:0.39NA WA EA 362
    rs1485679591,2
    C--82351560(+) TATACA/GTGTGC 2 -- int10--------
    rs761466771,2
    C--82381253(+) GGGTT-/ATCATGAT 2 -- int10--------
    rs102398751,2
    C--82387570(+) ggttgC/Tagaga 2 -- int12Minor allele frequency- T:0.17CSA WA 120
    rs30425541,2
    C--82392713(-) ATTAT-/TTAT  
            
    CTACC
    2 -- int10--------
    rs1995721021,2
    C--82393445(-) GCATTA/CCAAAA 2 -- int10--------
    rs125397961,2
    C,H--82422142(+) gcaagC/Gacccc 2 -- int10--------
    rs1136166521,2
    C,F--82422205(+) TTCTGC/TGCCCC 2 -- int11Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for SEMA3E (82993222 - 83243222 bp, first 250kb of SEMA3E)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SEMA3E (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734758CNV Deletion23290073
    esv2734755CNV Deletion23290073
    esv2734757CNV Deletion23290073
    esv2673845CNV Deletion23128226
    esv2674112CNV Deletion23128226
    esv2734756CNV Deletion23290073
    esv2519932CNV Deletion19546169
    nsv821148CNV Deletion20802225
    esv2734754CNV Deletion23290073
    esv2678160CNV Deletion23128226

    Human Gene Mutation Database (HGMD): SEMA3E
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEMA3E
    DNA2.0 Custom Variant and Variant Library Synthesis for SEMA3E

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 608166   
    OMIM disorders: 214800  
    8 diseases for SEMA3E:    
    About MalaCards
    ischemic retinopathy    charge syndrome    wolfram syndrome    retinitis
    prostate cancer    prostatitis    endotheliitis    cerebritis

    1 disease from the University of Copenhagen DISEASES database for SEMA3E:
    Endometrioid ovary carcinoma

    SEMA3E for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for SEMA3E gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 5.42 2 16024618 (1)
    tumors 0 11 18974298 (6), 15569615 (1), 16024618 (1)

    Genetic Association Database (GAD): SEMA3E
    Human Genome Epidemiology (HuGE) Navigator: SEMA3E (2 documents)

    Export disorders for SEMA3E gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for SEMA3E gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with SEMA3E)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1997)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    4. Transcription of a novel mouse semaphorin gene, M-semaH, correlates with the metastatic ability of mouse tumor cell lines. (PubMed id 9515811)1, 3 Christensen C.R....Lukanidin E. (Cancer Res. 1998)
    5. Semaphorin 3E expression correlates inversely with Plexin D1 during tumor progression. (PubMed id 18974298)1, 9 Roodink I....Leenders W. (Am. J. Pathol. 2008)
    6. The predictive value of semaphorins 3 expression in biopsies for biochemical recurrence of patients with low- and intermediate-risk prostate cancer. (PubMed id 23906303)1 Li K....Gao X. (Neoplasma 2013)
    7. Semaphorin 3E suppresses tumor cell death triggered by the plexin D1 dependence receptor in metastatic breast cancers. (PubMed id 24139859)1 Luchino J....Mann F. (Cancer Cell 2013)
    8. Tumour growth inhibition and anti-metastatic activity of a mutated furin-resistant Semaphorin 3E isoform. (PubMed id 22247010)1 Casazza A....Tamagnone L. (EMBO Mol Med 2012)
    9. A role for class 3 semaphorins in prostate cancer. (PubMed id 20949546)1 Blanc V....Williamson M. (Prostate 2011)
    10. The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle. (PubMed id 21555518)1 Warnatz H.J....Yaspo M.L. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 9723 HGNC: 10727 AceView: SEMA3E Ensembl:ENSG00000170381 euGenes: HUgn9723
    ECgene: SEMA3E Kegg: 9723 H-InvDB: SEMA3E

    (According to HUGE)
    About This Section

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    HUGE: KIAA0331

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SEMA3E Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SEMA3E gene:
    Search GeneIP for patents involving SEMA3E

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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