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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEMA3E Gene

protein-coding   GIFtS: 62
GCID: GC07M082993

sema domain, immunoglobulin domain (Ig), short basic domain,...


(Previous symbol: SEMAH)
 Explore 8 diseases affiliated with
SEMA3E via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SEMA3E    

Aliases
for SEMA3E gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted,
(Semaphorin) 3E1 2
     Coll-51
SEMAH1 2 3 5     M-SEMAH2
KIAA03311 3 5     Semaphorin-3E1
M-SemaK1 2     

External Ids:    HGNC: 107271   Entrez Gene: 97232   Ensembl: ENSG000001703817   OMIM: 6081665   UniProtKB: O150413   

Export aliases for SEMA3E gene to outside databases

Previous GC identifers: GC07M081528 GC07M082591 GC07M082605 GC07M082637 GC07M082831 GC07M077595


Summaries
for SEMA3E gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SEMA3E:
Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema)
domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based
on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and
2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via
multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin.
This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for
this gene.(provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: SEM3E_HUMAN, O15041
Function: Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the
actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits
adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after
birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays
an important role in ensuring the specificity of synapse formation (By similarity)




Genomic Views
for SEMA3E gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEMA3E gene promoter:
         STAT1   Pbx1a   Brachyury   STAT1beta   CUTL1   Evi-1   STAT1alpha   HEN1   STAT2   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SEMA3E promoter sequence
   Search SABiosciences Chromatin IP Primers for SEMA3E

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA3E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.11   Ensembl cytogenetic band:  7q21.11   HGNC cytogenetic band: 7q21.11

SEMA3E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA3E gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M082993:  view genomic region     (about GC identifiers)

Start:
 82,993,222 bp from pter      End:
 83,278,479 bp from pter
Size:
 285,258 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 82,325,430-82,610,645     

Proteins
for SEMA3E gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SEM3E_HUMAN, O15041 (See protein sequence)
Recommended Name: Semaphorin-3E precursor  
Size: 775 amino acids; 89228 Da
Subunit: Interacts with PLXND1 (By similarity)
Subcellular location: Secreted (By similarity)
Sequence caution: Sequence=BAA20789.2; Type=Erroneous initiation;
Secondary accessions: B4E1P1 Q75M94 Q75M97
Alternative splicing: 2 isoforms:  O15041-1   O15041-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEMA3E: NX_O15041

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15041

    • SEMA3E Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171600.1  NP_036563.1  

    ENSEMBL proteins: 
     ENSP00000303212   ENSP00000405052   ENSP00000412867   ENSP00000415184  
    Reactome Protein details: O15041
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for SEMA3E (Semaphorin 3E)
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    OriGene Protein Over-expression Lysate: SEMA3E
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    Novus Biologicals SEMA3E Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SEMA3E

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space TAS9515811
    GO:0016020membrane IEA--


    SEMA3E for ontologies           About GeneDecksing



    SEMA3E Antibody Products: 
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    ThermoFisher Antibodies for SEMA3E

    Assay Products for SEMA3E: 
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    Uscn ELISAs and CLIAs for SEMA3E

    Protein Domains /
    Families
    for SEMA3E gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SEMA3E for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR007110 Ig-like_dom
     IPR003659 Plexin-like
     IPR003599 Ig_sub
     IPR016201 Plexin-like_fold
     IPR015513 Semaphorin_3E

    Graphical View of Domain Structure for InterPro Entry O15041

    ProtoNet protein and cluster: O15041

    2 Blocks protein families:
    IPB001627 Semaphorin/CD100 antigen
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: SEM3E_HUMAN, O15041
    Similarity: Belongs to the semaphorin family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Sema domain


    Function
    for SEMA3E gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SEM3E_HUMAN, O15041
    Function: Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the
    actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits
    adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after
    birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays
    an important role in ensuring the specificity of synapse formation (By similarity)

         Summary:  

    During embryonic development, SEMA3E as signaling molecule
    affects the following cells: Endothelial tip cells in Arteries

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA3E
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA3E (see all 17):
    hsa-miR-16-2* hsa-miR-520d-5p hsa-miR-3692 hsa-miR-515-5p hsa-miR-3161 hsa-miR-629* hsa-miR-1252 hsa-miR-140-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SEMA3E 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA3E (see all 6)
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA3E

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SEMA3E

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA3E (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA3E (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SEMA3E (NM_012431)
    Sino Biological Human cDNA Clone for SEMA3E
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA3E 

    Cell Line
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    Search LifeMap BioReagents cell lines for SEMA3E

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3E

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--


    SEMA3E for ontologies           About GeneDecksing


    Animal Models:
         5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Sema3e):
     behavior/neurological  cardiovascular system  embryogenesis  nervous system  vision/eye 

    SEMA3E for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SEMA3E gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Axon guidance
    		Axon guidance1.00
    		Developmental Biology0.69
    2Other semaphorin interactions
    		Other semaphorin interactions1.00
    3Axon guidance
    		Axon guidance1.00
    4Sema4D in semaphorin signaling
    		Semaphorin interactions0.44

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for SEMA3E
        Developmental Biology
    Semaphorin interactions
    Other semaphorin interactions
    Axon guidance


    1         Kegg Pathway  (Kegg details for SEMA3E):
        Axon guidance


    SEMA3E for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEMA3E

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for SEMA3E (O150412, 3 ENSP000003032124) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLXND1Q9Y4D72, 3, ENSP000003171284MINT-4507932 MINT-4507966 I2D: score=1 STRING: ENSP00000317128
    PIP5K1BENSP000002653824STRING: ENSP00000265382
    RRASENSP000002467924STRING: ENSP00000246792
    NRP1ENSP000002653714STRING: ENSP00000265371
    SHBGENSP000003698164STRING: ENSP00000369816
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001569patterning of blood vessels ISS--
    GO:0001953negative regulation of cell-matrix adhesion ISS--
    GO:0002040sprouting angiogenesis ISS--
    GO:0007275multicellular organismal development ----
    GO:0007411axon guidance TAS--


    SEMA3E for ontologies           About GeneDecksing



    Drugs & Compounds
    for SEMA3E gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEMA3E
    Search CenterWatch for drugs/clinical trials and news about SEMA3E / SEM3E 

    Transcripts
    for SEMA3E gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SEMA3E gene (2 alternative transcripts): 
    NM_001178129.1  NM_012431.2  

    Unigene Cluster for SEMA3E:

    Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
    Hs.528721  [show with all ESTs]
    Unigene Representative Sequence: NM_012431
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307792(uc022agy.1 uc003uhy.2) ENST00000427262 ENST00000442159
    ENST00000453333

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SEMA3E
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA3E
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA3E (see all 17):
    hsa-miR-16-2* hsa-miR-520d-5p hsa-miR-3692 hsa-miR-515-5p hsa-miR-3161 hsa-miR-629* hsa-miR-1252 hsa-miR-140-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SEMA3E 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA3E (see all 6)
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA3E
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA3E (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA3E (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SEMA3E (NM_012431)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA3E
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA3E 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEMA3E
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA3E
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA3E

    Additional cDNA sequence: 

    AB002329.1 AK297209.1 AK303925.1 BC140706.1 BC144338.1 BC152458.1 

    3 DOTS entries:

    DT.40121024  DT.121094472  DT.121094475 

    24/31 AceView cDNA sequences (see all 31):

    AB002329 AI962050 AW242470 CD678104 AW450461 D81222 AI720166 BG184444 
    BM554988 BX641613 BM840320 CD671910 AI917271 CA488964 CD676931 BM764313 
    R85744 BM804054 BV188459 BF665578 BQ184075 BG899759 BG215143 BX095831 

    GeneLoc Exon Structure


    Expression
    for SEMA3E gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEMA3E expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAATGCAGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SEMA3E expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyPodocyte LayerPodocytesKidney
    CartilageLumbar Intervertebral DiscCartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    Endoderm progenitor-like cells (Generation and expan...)
    Definitive endoderm-like cells (Generation and expan...)
    Definitive endoderm-like cells (A scalable, suspensi...)
    Definitive Endoderm (Generation of beta c...)
    Epiblast-like cells (Reconstitution of mo...)

    See SEMA3E Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEMA3E

    SOURCE GeneReport for Unigene cluster: Hs.528721
        SABiosciences Custom PCR Arrays for SEMA3E
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3E

    Orthologs
    for SEMA3E gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SEMA3E gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SEMA3E1 sema domain, immunoglobulin domain (Ig), short basic more 77.63(n)
    81.55(a)    		   374089  NM_204242.1  NP_989573.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SEMA3E6
    		 --
    		 84(a)
    		 1 ↔ 1
    		 5(87503730-87592699)
    zebrafish
    (Danio rerio)    		 Actinopterygii sema3e1 sema domain, immunoglobulin domain (Ig), short basic more 62.18(n)
    60.72(a)    		   565658  NM_001045084.1  NP_001038549.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Sema-1b3 axon guidance 32(a)
    (best of 3)    		     --
    worm
    (Caenorhabditis elegans)    		 Secernentea mab-206
    smp-26
    		 SeMaPhorin related family member (smp-2)
    		 21(a)
    18(a)
    		 possible ortholog
    possible ortholog
    		 I(1644590-1651382)
    I(3667127-3671705)


    ENSEMBL Gene Tree for SEMA3E (if available)
    TreeFam Gene Tree for SEMA3E (if available) 

    Paralogs
    for SEMA3E gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEMA3E gene
    SEMA3C2  SEMA4F2  SEMA4B2  SEMA3F2  SEMA4C2  SEMA4A2  SEMA4G2  SEMA4D2  
    SEMA3A2  SEMA3G2  SEMA3D2  
    13 SIMAP similar genes for SEMA3E using alignment to 3 protein entries:     SEM3E_HUMAN (see all proteins):
    SEMA3A    SEMA3D    SEMA3C    SEMA3F    SEMA3G    SEMA3B
    SEMA4G    SEMA4F    SEMA4B    SEMA4C    SEMA4D    SEMA4D variant protein
    SEMA6D

    SEMA3E for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SEMA3E
    PGOHUM00000237128


    Genomic Variants
    for SEMA3E gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5433 NCBI SNPs in SEMA3E are shown (see all 5433)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs96565511,2
    		C,F,H,--82324962(+) GAAAGA/GATATG 2 -- ds500113Minor allele frequency- G:0.13NS EA NA WA CSA 1313
    rs802798721,2
    		F,--82325016(+) ATACAG/TAGAAG 2 -- ds50011Minor allele frequency- T:0.04NA 120
    rs774674521,2
    		F,--82325028(+) ACACTC/TCCATA 2 -- ds50011Minor allele frequency- T:0.03NA 120
    rs1126031921,2
    		--82325335(+) AAATAT/GCTATA 2 -- ds50012Minor allele frequency- G:0.10CSA WA 120
    rs769550651,2
    		C,F,--82325339(+) ATCTAT/GACAAT 2 -- ds50011Minor allele frequency- G:0.08WA 118
    rs605859051,2
    		C,--82325459(+) CAGGCC/TGGACT 2 -- ut311Minor allele frequency- T:0.50WA 2
    rs566538551,2
    		C,--82325723(+) GGTCAA/CTTCAT 2 -- ut312Minor allele frequency- C:0.21WA 120
    rs737098481,2
    		C,--82325887(+) TTCTAG/AGTATT 2 -- ut311Minor allele frequency- A:0.50WA 2
    rs1172474071,2
    		C,F,--82325904(+) ATTTTA/GGATAG 2 -- ut311Minor allele frequency- G:0.03NA 120
    rs765787691,2
    		--82325907(+) TTAGAT/AAGAAA 2 -- ut312Minor allele frequency- A:0.08NA WA 120

    HapMap Linkage Disequilibrium report for SEMA3E (82993222 - 83243222 bp, first 250kb of SEMA3E)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for SEMA3E
         3 CNVs: 0105 9577 100008
         3 Indels: 11305 94657 64877
    Human Gene Mutation Database (HGMD): SEMA3E

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    Disorders / Diseases
    for SEMA3E gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SEMA3E for disorders           About GeneDecksing

    OMIM gene information: 608166   
    OMIM disorders: 214800  
    8 diseases for SEMA3E:    About MalaCards
    endometrioid ovary carcinoma    charge syndrome    wolfram syndrome    prostate cancer
    retinitis    prostatitis    carcinoma    ischemic retinopathy

    1 disease from the University of Copenhagen DISEASES database for SEMA3E:
    Endometrioid ovary carcinoma

    2 Novoseek disease relationships for SEMA3E gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 5.42 2 16024618 (1)
    tumors 0 11 18974298 (6), 15569615 (1), 16024618 (1)

    Human Genome Epidemiology (HuGE) Navigator: SEMA3E (2 documents)

    Export disorders for SEMA3E gene to outside databases

    Publications
    for SEMA3E gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEMA3E gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with SEMA3E)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (1997)
    2. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    3. Transcription of a novel mouse semaphorin gene, M-semaH, correlates with the metastatic ability of mouse tumor cell lines. (PubMed id 9515811)1, 3 Christensen C.R....Lukanidin E. (1998)
    4. Semaphorin 3E expression correlates inversely with Plexin D1 during tumor progression. (PubMed id 18974298)1, 9 Roodink I....Leenders W. (2008)
    5. Tumour growth inhibition and anti-metastatic activity of a mutated furin-resistant Semaphorin 3E isoform. (PubMed id 22247010)1 Casazza A....Tamagnone L. (2012)
    6. A role for class 3 semaphorins in prostate cancer. (PubMed id 20949546)1 Blanc V....Williamson M. (2011)
    7. Phosphatidylinositol-4-phosphate 5-kinase and GEP100/ Brag2 protein mediate antiangiogenic signaling by semaphorin 3E-plexin-D1 throu gh Arf6 protein. (PubMed id 21795701)1 Sakurai A....Gutkind J.S. (2011)
    8. The BTB and CNC homology 1 (BACH1) target genes are i nvolved in the oxidative stress response and in control of the cell cycle. (PubMed id 21555518)1 Warnatz H.J....Yaspo M.L. (2011)
    9. Sema3E/plexin-D1 mediated epithelial-to-mesenchymal t ransition in ovarian endometrioid cancer. (PubMed id 21559368)1 Tseng C.H....Huang P.H. (2011)
    10. Sema3E-PlexinD1 signaling selectively suppresses diso riented angiogenesis in ischemic retinopathy in mice. (PubMed id 21505259)1 Fukushima Y....Uemura A. (2011)

    External Searches for SEMA3E gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SEMA3E gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9723 HGNC: 10727 AceView: SEMA3E Ensembl:ENSG00000170381 euGenes: HUgn9723
    ECgene: SEMA3E Kegg: 9723 H-InvDB: SEMA3E

    Other Databases showing SEMA3E gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0331

    Specialized Databases showing SEMA3E gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEMA3E Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SEMA3E gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SEMA3E gene:
    Search GeneIP for patents involving SEMA3E

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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