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Aliases for SEMA3E Gene

Aliases for SEMA3E Gene

  • Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3E 2 3
  • SEMAH 3 4 6
  • KIAA0331 4 6
  • Semaphorin-3E 3
  • M-Sema H 2
  • M-SEMAH 3
  • M-SemaK 3
  • Coll-5 3

External Ids for SEMA3E Gene

Previous Symbols for SEMA3E Gene

  • SEMAH

Summaries for SEMA3E Gene

Entrez Gene Summary for SEMA3E Gene

  • Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

GeneCards Summary for SEMA3E Gene

SEMA3E (Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3E) is a Protein Coding gene. Diseases associated with SEMA3E include charge syndrome and ischemic retinopathy. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA4G.

UniProtKB/Swiss-Prot for SEMA3E Gene

  • Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMA3E Gene

Genomics for SEMA3E Gene

Genomic Location for SEMA3E Gene

Start:
83,363,906 bp from pter
End:
83,649,163 bp from pter
Size:
285,258 bases
Orientation:
Minus strand

Genomic View for SEMA3E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEMA3E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA3E Gene

Regulatory Elements for SEMA3E Gene

Proteins for SEMA3E Gene

  • Protein details for SEMA3E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15041-SEM3E_HUMAN
    Recommended name:
    Semaphorin-3E
    Protein Accession:
    O15041
    Secondary Accessions:
    • B4E1P1
    • Q75M94
    • Q75M97

    Protein attributes for SEMA3E Gene

    Size:
    775 amino acids
    Molecular mass:
    89228 Da
    Quaternary structure:
    • Interacts with PLXND1.
    SequenceCaution:
    • Sequence=BAA20789.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SEMA3E Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEMA3E Gene

Proteomics data for SEMA3E Gene at MOPED

Post-translational modifications for SEMA3E Gene

  • Glycosylation at Asn44, Asn126, Asn330, Asn595, and Asn596

Other Protein References for SEMA3E Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SEMA3E Gene

Domains for SEMA3E Gene

Gene Families for SEMA3E Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • SEMA :Semaphorins

UniProtKB/Swiss-Prot:

SEM3E_HUMAN
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.:
    • O15041
  • Contains 1 Sema domain.:
    • O15041
Family:
  • Belongs to the semaphorin family.:
    • O15041
genes like me logo Genes that share domains with SEMA3E: view

Function for SEMA3E Gene

Molecular function for SEMA3E Gene

UniProtKB/Swiss-Prot Function: Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity).

LifeMap Function Summary for SEMA3E Gene

It affects the following cells:

Gene Ontology (GO) - Molecular Function for SEMA3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0005515 protein binding IPI 17318185
GO:0030215 semaphorin receptor binding IEA --
genes like me logo Genes that share ontologies with SEMA3E: view
genes like me logo Genes that share phenotypes with SEMA3E: view

miRNA for SEMA3E Gene

miRTarBase miRNAs that target SEMA3E

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEMA3E Gene

Localization for SEMA3E Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA3E Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEMA3E Gene COMPARTMENTS Subcellular localization image for SEMA3E gene
Compartment Confidence
extracellular 4
cytoskeleton 1
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SEMA3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 9515811
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SEMA3E: view

Pathways for SEMA3E Gene

genes like me logo Genes that share pathways with SEMA3E: view

Pathways by source for SEMA3E Gene

1 KEGG pathway for SEMA3E Gene

Gene Ontology (GO) - Biological Process for SEMA3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001569 patterning of blood vessels ISS --
GO:0001953 negative regulation of cell-matrix adhesion ISS --
GO:0002040 sprouting angiogenesis ISS --
GO:0007275 multicellular organismal development --
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with SEMA3E: view

Transcripts for SEMA3E Gene

Unigene Clusters for SEMA3E Gene

Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA3E Gene

No ASD Table

Relevant External Links for SEMA3E Gene

GeneLoc Exon Structure for
SEMA3E
ECgene alternative splicing isoforms for
SEMA3E

Expression for SEMA3E Gene

mRNA expression in normal human tissues for SEMA3E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEMA3E Gene

This gene is overexpressed in Esophagus - Muscularis (4.4) and Esophagus - Gastroesophageal Junction (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SEMA3E Gene

SOURCE GeneReport for Unigene cluster for SEMA3E Gene Hs.528721

genes like me logo Genes that share expressions with SEMA3E: view

Orthologs for SEMA3E Gene

This gene was present in the common ancestor of animals.

Orthologs for SEMA3E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEMA3E 36
  • 99.57 (n)
  • 99.74 (a)
SEMA3E 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SEMA3E 36
  • 90.32 (n)
  • 93.29 (a)
SEMA3E 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEMA3E 36
  • 89.27 (n)
  • 92.91 (a)
SEMA3E 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sema3e 36
  • 85.16 (n)
  • 90.19 (a)
Sema3e 16
Sema3e 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEMA3E 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEMA3E 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sema3e 36
  • 84.77 (n)
  • 89.42 (a)
chicken
(Gallus gallus)
Aves SEMA3E 36
  • 77.63 (n)
  • 81.55 (a)
SEMA3E 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEMA3E 37
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sema3e 36
  • 73.78 (n)
  • 76.27 (a)
zebrafish
(Danio rerio)
Actinopterygii sema3e 36
  • 62.4 (n)
  • 60.97 (a)
sema3e 37
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sema-1b 38
  • 32 (a)
Sema-2a 38
  • 32 (a)
CG4383 38
  • 31 (a)
Species with no ortholog for SEMA3E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEMA3E Gene

ENSEMBL:
Gene Tree for SEMA3E (if available)
TreeFam:
Gene Tree for SEMA3E (if available)

Paralogs for SEMA3E Gene

Selected SIMAP similar genes for SEMA3E Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SEMA3E Gene

genes like me logo Genes that share paralogs with SEMA3E: view

Variants for SEMA3E Gene

Sequence variations from dbSNP and Humsavar for SEMA3E Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs41998 -- 83,637,040(-) ACACA(C/T)ACACA intron-variant
rs41999 -- 83,636,772(-) CAATC(A/T)TCCCA intron-variant
rs42000 -- 83,636,297(+) AAGGG(A/G)CAGAA intron-variant
rs42001 -- 83,632,387(-) gaatt(A/G)aagct intron-variant
rs42002 -- 83,631,769(-) CTCAT(A/G)GACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEMA3E Gene

Variant ID Type Subtype PubMed ID
nsv824189 CNV Gain 20364138
esv2519932 CNV Deletion 19546169
dgv1120n67 CNV Gain 20364138
nsv821148 CNV Deletion 20802225
nsv824191 CNV Gain 20364138
esv2734754 CNV Deletion 23290073
esv2678160 CNV Deletion 23128226
esv2734755 CNV Deletion 23290073
esv2734756 CNV Deletion 23290073
esv2734757 CNV Deletion 23290073
esv2734758 CNV Deletion 23290073
esv272106 CNV Insertion 20981092
nsv511976 CNV Loss 21212237
esv2673845 CNV Deletion 23128226
esv27343 CNV Loss 19812545
esv33579 CNV Loss 17666407
esv1184566 CNV Insertion 17803354
dgv7366n71 CNV Loss 21882294
nsv888608 CNV Loss 21882294
nsv824195 CNV Loss 20364138
nsv526178 CNV Loss 19592680
nsv818531 CNV Gain 17921354
nsv483120 CNV Loss 15286789
esv2674112 CNV Deletion 23128226

Relevant External Links for SEMA3E Gene

HapMap Linkage Disequilibrium report
SEMA3E
Human Gene Mutation Database (HGMD)
SEMA3E

Disorders for SEMA3E Gene

(1) OMIM Diseases for SEMA3E Gene (608166)

(1) University of Copenhagen DISEASES for SEMA3E Gene

(2) Novoseek inferred disease relationships for SEMA3E Gene

Disease -log(P) Hits PubMed IDs
cancer 5.42 1
tumors 0 8

Relevant External Links for SEMA3E

Genetic Association Database (GAD)
SEMA3E
Human Genome Epidemiology (HuGE) Navigator
SEMA3E
genes like me logo Genes that share disorders with SEMA3E: view

No data available for UniProtKB/Swiss-Prot for SEMA3E Gene

Publications for SEMA3E Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4
  2. Transcription of a novel mouse semaphorin gene, M-semaH, correlates with the metastatic ability of mouse tumor cell lines. (PMID: 9515811) Christensen C.R. … Lukanidin E. (Cancer Res. 1998) 2 3
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. Semaphorin 3E expression correlates inversely with Plexin D1 during tumor progression. (PMID: 18974298) Roodink I. … Leenders W. (Am. J. Pathol. 2008) 3 23

Products for SEMA3E Gene

Sources for SEMA3E Gene

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