Aliases for SEMA3E Gene
External Ids for SEMA3E Gene
Previous HGNC Symbols for SEMA3E Gene
Previous GeneCards Identifiers for SEMA3E Gene
Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
GeneCards Summary for SEMA3E Gene
SEMA3E (Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3E) is a Protein Coding gene. Diseases associated with SEMA3E include charge syndrome and severe nonproliferative diabetic retinopathy. Among its related pathways are Developmental Biology and Semaphorin interactions. GO annotations related to this gene include receptor activity and semaphorin receptor binding. An important paralog of this gene is SEMA4G.
UniProtKB/Swiss-Prot for SEMA3E Gene
Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity).