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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEMA3D Gene

protein-coding   GIFtS: 56
GCID: GC07M084624

Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain,...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted,
(Semaphorin) 3D1 2
Sema-Z22
coll-22
Collapsin 22
semaphorin-3D2

External Ids:    HGNC: 107261   Entrez Gene: 2231172   Ensembl: ENSG000001539937   OMIM: 6099075   UniProtKB: O950253   

Export aliases for SEMA3D gene to outside databases

Previous GC identifers: GC00U990482 GC07M083163 GC07M084226 GC07M084240 GC07M084236 GC07M084269 GC07M084462 GC07M079234


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SEMA3D Gene: 
SEMA3D (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D) is a protein-coding gene. Diseases associated with SEMA3D include osteochondrosis, and wolfram syndrome. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA3C.

UniProtKB/Swiss-Prot: SEM3D_HUMAN, O95025
Function: Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues
toward specific neuronal populations. Binds to neuropilin (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEMA3D gene promoter:
         Sox5   ATF-2   CUTL1   Cdc5   FOXL1   RORalpha2   SRY   POU2F1   FOXO4   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SEMA3D promoter sequence
   Search SABiosciences Chromatin IP Primers for SEMA3D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA3D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.11   Ensembl cytogenetic band:  7q21.11   HGNC cytogenetic band: 7q21.11

SEMA3D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA3D gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M084624:  view genomic region     (about GC identifiers)

Start:
84,624,869 bp from pter      End:
84,816,171 bp from pter
Size:
191,303 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 83,956,759-84,083,147     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SEM3D_HUMAN, O95025 (See protein sequence)
Recommended Name: Semaphorin-3D precursor  
Size: 777 amino acids; 89651 Da
Subcellular location: Secreted (By similarity)
Sequence caution: Sequence=AAH29590.1; Type=Erroneous initiation;
Secondary accessions: A6NK46 Q6UW77 Q8NCQ1

Explore the universe of human proteins at neXtProt for SEMA3D: NX_O95025

Explore proteomics data for SEMA3D at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95025

  • SEMA3D Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SEMA3D Protein Expression
    REFSEQ proteins: NP_689967.2  
    ENSEMBL proteins: 
     ENSP00000284136   ENSP00000401366  

    Human Recombinant Protein Products for SEMA3D: 
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    Novus Biologicals SEMA3D Proteins
    Novus Biologicals SEMA3D Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEMA3D 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0016020membrane IEA--

    SEMA3D for ontologies           About GeneDecksing



    SEMA3D Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for SEMA3D 

    Assay Products for SEMA3D: 
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    Cloud-Clone Corp. CLIAs for SEMA3D


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    VSET: Immunoglobulin superfamily / V-set domain containing
    SEMA: Semaphorins

    5/9 InterPro protein domains (see all 9):
     IPR007110 Ig-like_dom
     IPR003659 Plexin-like
     IPR003599 Ig_sub
     IPR016201 Plexin-like_fold
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry O95025

    ProtoNet protein and cluster: O95025

    3 Blocks protein domains:
    IPB001627 Semaphorin/CD100 antigen
    IPB003599 Immunoglobulin subtype
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: SEM3D_HUMAN, O95025
    Domain: Strong binding to neuropilin is mediated by the carboxy third of the protein
    Similarity: Belongs to the semaphorin family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 PSI domain
    Similarity: Contains 1 Sema domain


    SEMA3D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEM3D_HUMAN, O95025
    Function: Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues
    toward specific neuronal populations. Binds to neuropilin (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----
         
    SEMA3D for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SEMA3D:
     Increased HPV18 LCR reporter a 

         1 MGI phenotypic allele for Sema3d (no phenotypes)

    SEMA3D for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SEMA3D 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SEMA3D

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEMA3D 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEMA3D 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA3D
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA3D (see all 24):
    hsa-miR-4291 hsa-miR-3607-5p hsa-miR-202 hsa-miR-15a hsa-miR-374a hsa-miR-885-5p hsa-miR-424 hsa-miR-1468
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SEMA3D
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA3D

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SEMA3D

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SEMA3D (see all 7)
    OriGene ORF clones in mouse, rat for SEMA3D
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEMA3D (NM_152754)
    Browse Sino Biological Human cDNA Clones
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                         Customized lentivirus expression plasmids for stable overexpression of SEMA3D 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3D


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SEMA3D About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Axon guidance

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for SEMA3D):
        Axon guidance


    SEMA3D for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEMA3D

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SEMA3D (ENSP000002841364) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NRP1ENSP000002653714STRING: ENSP00000265371
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development ----
    GO:0007399nervous system development IEA--
    GO:0030154cell differentiation IEA--

    SEMA3D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEMA3D (SEM3D)

    Search CenterWatch for drugs/clinical trials and news about SEMA3D / SEM3D

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SEMA3D gene: 
    NM_152754.2  

    Unigene Cluster for SEMA3D:

    Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
    Hs.201340  [show with all ESTs]
    Unigene Representative Sequence: NM_152754
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000284136(uc003uib.3 uc003uic.3 uc010led.3) ENST00000484038
    ENST00000463315 ENST00000444867(uc010lee.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA3D
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA3D (see all 24):
    hsa-miR-4291 hsa-miR-3607-5p hsa-miR-202 hsa-miR-15a hsa-miR-374a hsa-miR-885-5p hsa-miR-424 hsa-miR-1468
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SEMA3D
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA3D
    Clone
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    OriGene clones in human, mouse for SEMA3D (see all 7)
    OriGene ORF clones in mouse, rat for SEMA3D
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEMA3D (NM_152754)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA3D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA3D
    Sirion Biotech Customized lentivirus for stable overexpression of SEMA3D 
                         Customized lentivirus expression plasmids for stable overexpression of SEMA3D 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SEMA3D
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEMA3D
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA3D
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA3D

    Additional mRNA sequence: 

    AK309116.1 AY358937.1 BC029590.1 BX648652.1 

    3 DOTS entries:

    DT.75115741  DT.100008758  DT.100737544 

    24/39 AceView cDNA sequences (see all 39):

    AU119300 BQ082184 BM680626 BI492794 AI624103 NM_152754 AI732612 CA391352 
    CA418807 AY358937 CB410875 BC029590 AA969051 BM728065 BX648652 BI461517 
    AI733905 AA165024 AA329383 AW151200 AA159810 BI463636 BG745324 CD299369 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEMA3D expression in normal human tissues (normalized intensities)      SEMA3D embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGTTCTAT
    SEMA3D Expression
    About this image


    SEMA3D expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 7 entries
             Angioblasts Epicardium
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Vascular Smooth Muscle Cells Coronary Vessels
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Angioblasts Epicardium
     
     Bone (Muscoskeletal System)
             Zeugopod Growth Plate
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer

    See SEMA3D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEMA3D

    SOURCE GeneReport for Unigene cluster: Hs.201340
        SABiosciences Custom PCR Arrays for SEMA3D
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SEMA3D gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sema3d1 , 5 sema domain, immunoglobulin domain (Ig), short basic more1, 5 89.15(n)1
    92.92(a)1
      5 (3.97 cM)5
    1081511  NM_028882.41  NP_083158.31 
     123831665 
    chicken
    (Gallus gallus)
    Aves SEMA3D1 sema domain, immunoglobulin domain (Ig), short basic more 80.09(n)
    87.11(a)
      396332  NM_205373.1  NP_990704.1 
    lizard
    (Anolis carolinensis)
    Reptilia SEMA3D6
    --
    --
    76(a)
    46(a)
    1 ↔ 1
    possible ortholog
    5(88669385-88785094)
    2(152315794-152368572)
    zebrafish
    (Danio rerio)
    Actinopterygii sema3d1 semaphorin 3d 63.49(n)
    64.37(a)
      30250  NM_131048.1  NP_571123.1 


    ENSEMBL Gene Tree for SEMA3D (if available)
    TreeFam Gene Tree for SEMA3D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEMA3D gene
    SEMA3C2  SEMA4F2  SEMA3E2  SEMA4B2  SEMA4C2  SEMA3F2  SEMA4A2  SEMA4D2  
    SEMA4G2  SEMA3A2  SEMA3G2  
    14 SIMAP similar genes for SEMA3D using alignment to 2 protein entries:     SEM3D_HUMAN (see all proteins):
    SEMA3A    SEMA3E    SEMA3B    SEMA3F    SEMA3C    SEMA3G
    SEMA6D    SEMA4A    SEMA4G    SEMA4D    SEMA4D variant protein    SEMA4C
    SEMA4B    SEMA4F

    SEMA3D for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2249 SNPs in SEMA3D are shown (see all 2249)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1835323491,2
    --84624427(+) TTCACA/GTGTGC 1 -- ds50010--------
    rs759164581,2
    C,F--84624518(+) ACCTTA/CCTCTT 1 -- ds50012Minor allele frequency- C:0.13WA EA 238
    rs1874988011,2
    --84624687(+) ATGGTA/GTCAAA 1 -- ds50010--------
    rs78064001,2
    C,F,A,H--84624924(+) AAATAT/CACATT 1 -- ut31 ese317Minor allele frequency- C:0.17NS EA NA WA 2334
    rs1919597601,2
    --84624960(+) ACAAGA/GCTACA 1 -- ut310--------
    rs783093501,2
    C,F--84624980(+) AAATAG/TCAGAA 1 -- ut311Minor allele frequency- T:0.09WA 118
    rs1503405191,2
    C--84625095(+) CTCAAA/GCCCTT 1 -- ut310--------
    rs1837056311,2
    --84625102(+) CCTTTC/TCATAA 1 -- ut310--------
    rs1169561011,2
    C,F--84625335(+) CCAATA/GAGGTT 1 -- ut311Minor allele frequency- G:0.06EA 120
    rs1164080971,2
    C,F--84625624(+) GAAGAA/TCCAAA 1 -- ut311Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for SEMA3D (84624869 - 84816171 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SEMA3D:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422324CNV Deletion17116639
    nsv888645CNV Loss21882294
    nsv519125CNV Loss19592680
    nsv521507CNV Loss19592680
    nsv888633CNV Gain21882294


    Human Gene Mutation Database (HGMD): SEMA3D
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SEMA3D
    DNA2.0 Custom Variant and Variant Library Synthesis for SEMA3D

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609907    OMIM disorders: --

    6 diseases for SEMA3D:    About MalaCards
    osteochondrosis    wolfram syndrome    paralysis    periodontitis
    schizophrenia    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for SEMA3D:
    Wolfram syndrome     Hirschsprung's disease

    SEMA3D for disorders           About GeneDecksing

    Genetic Association Database (GAD): SEMA3D
    Human Genome Epidemiology (HuGE) Navigator: SEMA3D (2 documents)

    Export disorders for SEMA3D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEMA3D gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with SEMA3D)
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    1. Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. (PubMed id 19054571)1, 4 GregA^rio S.P....Dias-Neto E. (2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Semaphorin profiling of periodontal fibroblasts and osteoblasts. (PubMed id 15329371)1, 9 Lallier T.E. (2004)
    6. Semaphorin 3d signaling defects are associated with an omalous pulmonary venous connections. (PubMed id 23685842)1 Degenhardt K....Epstein J.A. (2013)
    7. Mutational spectrum of semaphorin 3A and semaphorin 3D genes in Spanish Hirschsprung patients. (PubMed id 23372769)1 Luzon-Toro B....Borrego S. (2013)
    8. Possible association of the semaphorin 3D gene (SEMA3 D) with schizophrenia. (PubMed id 20684831)1 Fujii T....Kunugi H. (2010)
    9. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with BehAset's disea se. (PubMed id 20622878)4 Remmers E.F....GA1l A. (2010)
    10. Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells. (PubMed id 18818766)1 Kigel B....Neufeld G. (2008)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 223117 HGNC: 10726 AceView: SEMA3D Ensembl:ENSG00000153993 euGenes: HUgn223117
    ECgene: SEMA3D Kegg: 223117 H-InvDB: SEMA3D

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEMA3D Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEMA3D gene:
    Search GeneIP for patents involving SEMA3D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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