Aliases for SEMA3D Gene
External Ids for SEMA3D Gene
Previous GeneCards Identifiers for SEMA3D Gene
This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin like domain and a C-terminal basic domain. The protein encoded by this gene binds neuropilin and plays an important role in cardiovascular development. [provided by RefSeq, Aug 2016]
GeneCards Summary for SEMA3D Gene
SEMA3D (Semaphorin 3D) is a Protein Coding gene. Diseases associated with SEMA3D include Hirschsprung Disease 1 and Osteochondrosis. Among its related pathways are Axon guidance. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA3A.
UniProtKB/Swiss-Prot for SEMA3D Gene
Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin (By similarity).