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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SEMA3D Gene

protein-coding GIFtS: 53
GCID: GC07M084624

sema domain, immunoglobulin domain (Ig), short basic domain,...

Explore 7 diseases affiliated with
SEMA3D via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3D¹ ²
Sema-Z2¹ ²
Coll-2¹
Collapsin 2²
Semaphorin-3D¹

External Ids:	HGNC: 10726¹	Entrez Gene: 223117²	Ensembl: ENSG00000153993⁷	OMIM: 609907⁵	UniProtKB: O95025³

Export aliases for SEMA3D gene to outside databases

Previous GC identifers: GC00U990482 GC07M083163 GC07M084226 GC07M084240 GC07M084236 GC07M084269 GC07M084462 GC07M079234

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SEM3D_HUMAN, O95025

Function: Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward

specific neuronal populations. Binds to neuropilin (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SEMA3D gene promoter:
Sox5 ATF-2 CUTL1 Cdc5 FOXL1 RORalpha2 SRY POU2F1 FOXO4 POU2F1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SEMA3D promoter sequence

Search SABiosciences Chromatin IP Primers for SEMA3D

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA3D

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.11 Ensembl cytogenetic band: 7q21.11 HGNC cytogenetic band: 7q21.11

SEMA3D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA3D gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M084624: view genomic region (about GC identifiers)

Start:	84,624,869 bp from pter	End:	84,816,171 bp from pter
Size:	191,303 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 83,956,759-84,083,147

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SEM3D_HUMAN, O95025 (See protein sequence)

Recommended Name: Semaphorin-3D precursor

Size: 777 amino acids; 89651 Da

Subcellular location: Secreted (By similarity)

Sequence caution: Sequence=AAH29590.1; Type=Erroneous initiation;

Secondary accessions: A6NK46 Q6UW77 Q8NCQ1

Explore the universe of human proteins at neXtProt for SEMA3D: NX_O95025

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O95025

SEMA3D Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_689967.2

ENSEMBL proteins:

ENSP00000284136 ENSP00000401366

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals SEMA3D Proteins Novus Biologicals SEMA3D Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SEMA3D

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0016020	membrane	IEA	--

SEMA3D for ontologies About GeneDecksing

SEMA3D Antibody Products:

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	Novus Biologicals SEMA3D Antibodies
	Search for Antibodies for SEMA3D at Abcam
	Uscn Antibodies for SEMA3D
	Search ThermoFisher Antibodies for SEMA3D

Assay Products for SEMA3D:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for SEMA3D
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	Uscn ELISAs and CLIAs for SEMA3D

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SEMA3D for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR007110 Ig-like_dom

IPR003659 Plexin-like

IPR003599 Ig_sub

IPR016201 Plexin-like_fold

IPR013783 Ig-like_fold

Graphical View of Domain Structure for InterPro Entry O95025

ProtoNet protein and cluster: O95025

3 Blocks protein families:

IPB001627 Semaphorin/CD100 antigen

IPB003599 Immunoglobulin subtype

IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: SEM3D_HUMAN, O95025

Domain: Strong binding to neuropilin is mediated by the carboxy third of the protein

Similarity: Belongs to the semaphorin family

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

Similarity: Contains 1 PSI domain

Similarity: Contains 1 Sema domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SEM3D_HUMAN, O95025

Function: Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward

specific neuronal populations. Binds to neuropilin (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: SEMA3D Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA3D
		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA3D (see all 24):
		hsa-miR-4291 hsa-miR-3607-5p hsa-miR-202 hsa-miR-15a hsa-miR-374a hsa-miR-885-5p hsa-miR-424 hsa-miR-1468

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA3D (see all 7) OriGene shRNA RFP: SEMA3D OriGene siRNA: SEMA3D
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA3D

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SEMA3D

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA3D (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA3D OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SEMA3D (NM_152754)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA3D
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA3D

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SEMA3D
		Search LifeMap BioReagents cell lines for SEMA3D

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3D

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--

SEMA3D for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SEMA3D:

Increased HPV18 LCR reporter a

Animal Models:
1 MGI phenotypic allele

for Sema3d (no phenotypes)

SEMA3D for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Axon guidance

Axon guidance

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Kegg Pathway (Kegg details for SEMA3D):

Axon guidance

SEMA3D for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SEMA3D

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for SEMA3D (ENSP00000284136⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NRP1	ENSP00000265371⁴	STRING: ENSP00000265371

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007399	nervous system development	IEA	--
GO:0030154	cell differentiation	IEA	--

SEMA3D for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SEMA3D
Search CenterWatch for drugs/clinical trials and news about SEMA3D / SEM3D

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SEMA3D gene:

NM_152754.2

Unigene Cluster for SEMA3D:

Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D

Hs.201340 [show with all ESTs]

Unigene Representative Sequence: NM_152754

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000284136(uc003uib.3 uc003uic.3 uc010led.3) ENST00000484038

ENST00000463315 ENST00000444867(uc010lee.1)

miRNA Products:		OriGene 3'-UTR Clone: SEMA3D Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA3D
		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA3D (see all 24):
		hsa-miR-4291 hsa-miR-3607-5p hsa-miR-202 hsa-miR-15a hsa-miR-374a hsa-miR-885-5p hsa-miR-424 hsa-miR-1468

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA3D (see all 7) OriGene shRNA RFP: SEMA3D OriGene siRNA: SEMA3D
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA3D

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA3D (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA3D OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SEMA3D (NM_152754)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA3D
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA3D

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEMA3D Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SEMA3D
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA3D
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA3D

Additional cDNA sequence:

AK309116.1 AY358937.1 BC029590.1 BX648652.1

3 DOTS entries:

DT.75115741 DT.100008758 DT.100737544

24/39 AceView cDNA sequences (see all 39):

BQ082184 BC029590 BM728065 AY358937 BI492794 AU119300 CB410875 BM680626

NM_152754 CA391352 AI732612 AI624103 CA418807 BX648652 AA969051 BI463636

AA329383 AA165024 AI733905 CD299369 BG745324 BI461517 AW151200 BI495036

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SEMA3D expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTGTTCTAT

About this image

SEMA3D expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Thoracic Perivascular Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

See SEMA3D Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEMA3D

SOURCE GeneReport for Unigene cluster: Hs.201340

SABiosciences Custom PCR Arrays for SEMA3D

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEMA3D Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SEMA3D
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA3D
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA3D

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3D

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SEMA3D gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SEMA3D¹	sema domain, immunoglobulin domain (Ig), short basic more	80.09(n) 87.11(a)		396332 NM_205373.1 NP_990704.1
lizard (Anolis carolinensis)	Reptilia	SEMA3D⁶	--	76(a)	1 ↔ 1	5(88671953-88785094)
zebrafish (Danio rerio)	Actinopterygii	sema3d¹	semaphorin 3d	63.49(n) 64.37(a)		30250 NM_131048.1 NP_571123.1
fruit fly (Drosophila melanogaster)	Insecta	Sema-2a⁶ Sema-2b⁶	Semaphorin-2b	25(a) 23(a)	possible ortholog possible ortholog	2R(12387701-12420934) 2R(12274029-12319263)
worm (Caenorhabditis elegans)	Secernentea	mab-20⁶ smp-2⁶	SeMaPhorin related family member (smp-2)	22(a) 17(a)	possible ortholog possible ortholog	I(1644590-1651382) I(3667127-3671705)

ENSEMBL Gene Tree for SEMA3D (if available)
TreeFam Gene Tree for SEMA3D (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SEMA3D gene

SEMA3C² SEMA4F² SEMA3E² SEMA4B² SEMA3F² SEMA4C² SEMA4A² SEMA4G²

SEMA4D² SEMA3A² SEMA3G²

14 SIMAP similar genes for SEMA3D using alignment to 2 protein entries: SEM3D_HUMAN (see all proteins):

SEMA3A SEMA3E SEMA3B SEMA3F SEMA3C SEMA3G

SEMA6D SEMA4A SEMA4G SEMA4D SEMA4D variant protein SEMA4C

SEMA4B SEMA4F

SEMA3D for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183532349^1,2		--	84624427(+)	`TTCACA/GTGTGC`	1	--	ds500¹		0	--	--	--	--
rs75916458^1,2	C,F,	--	84624518(+)	`ACCTTA/CCTCTT`	1	--	ds500¹		2		WA EA	238
rs187498801^1,2		--	84624687(+)	`ATGGTA/GTCAAA`	1	--	ds500¹		0	--	--	--	--
rs7806400^1,2	C,F,A,H,	--	84624924(+)	`AAATAT/CACATT`	1	--	ut3¹ ese³		17		NS EA NA WA	2334
rs191959760^1,2		--	84624960(+)	`ACAAGA/GCTACA`	1	--	ut3¹		0	--	--	--	--
rs78309350^1,2	F,	--	84624980(+)	`AAATAG/TCAGAA`	1	--	ut3¹		1		WA	118
rs150340519^1,2		--	84625095(+)	`CTCAAA/GCCCTT`	1	--	ut3¹		0	--	--	--	--
rs183705631^1,2		--	84625102(+)	`CCTTTC/TCATAA`	1	--	ut3¹		0	--	--	--	--
rs116956101^1,2	C,F,	--	84625335(+)	`CCAATA/GAGGTT`	1	--	ut3¹		1		EA	120
rs116408097^1,2	F,	--	84625624(+)	`GAAGAA/TCCAAA`	1	--	ut3¹		1		WA	118

HapMap Linkage Disequilibrium report for SEMA3D (84624869 - 84816171 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SEMA3D: --
Human Gene Mutation Database (HGMD): SEMA3D

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEMA3D

DNA2.0 Custom Variant and Variant Library Synthesis for SEMA3D

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SEMA3D for disorders           About GeneDecksing

OMIM gene information: 609907    OMIM disorders: --

7 diseases for SEMA3D:    About MalaCards

wolfram syndrome osteochondrosis paralysis osteoarthritis

periodontitis schizophrenia neuronitis

1 disease from the University of Copenhagen DISEASES database for SEMA3D:

Wolfram syndrome

Human Genome Epidemiology (HuGE) Navigator: SEMA3D (2 documents)

Export disorders for SEMA3D gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SEMA3D gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with SEMA3D)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Semaphorin profiling of periodontal fibroblasts and osteoblasts. (PubMed id 15329371)^{1, 9} Lallier T.E. (2004)
Possible association of the semaphorin 3D gene (SEMA3 D) with schizophrenia. (PubMed id 20684831)¹ Fujii T....Kunugi H. (2010)
Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. (PubMed id 19054571)¹ GregA^rio S.P....Dias-Neto E. (2009)
Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells. (PubMed id 18818766)¹ Kigel B....Neufeld G. (2008)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)¹ Scherer S.W.... Tsui L.-C. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Sema3D, Sema3F, and Sema5A are expressed in overlapping and distinct patterns in chick embryonic heart. (PubMed id 16261621)⁹ Jin Z....Bao Z.Z. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 223117	HGNC: 10726	AceView: SEMA3D	Ensembl:ENSG00000153993	euGenes: HUgn223117
ECgene: SEMA3D	Kegg: 223117	H-InvDB: SEMA3D

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SEMA3D	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SEMA3D gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SEMA3D gene:
Search GeneIP for patents involving SEMA3D

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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SEMA3D Gene

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SEMA3D Gene

sema domain, immunoglobulin domain (Ig), short basic domain,...

Aliasesfor SEMA3D gene

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Genomic Viewsfor SEMA3D gene

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Protein Domains /Familiesfor SEMA3D gene

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External Searches for SEMA3D gene

Genome Databases showing SEMA3D gene

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Specialized Databases showing SEMA3D gene

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Aliases
for SEMA3D gene

Summaries
for SEMA3D gene

Genomic Views
for SEMA3D gene

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for SEMA3D gene

Protein Domains /
Families
for SEMA3D gene

Function
for SEMA3D gene

Pathways & Interactions
for SEMA3D gene

Drugs & Compounds
for SEMA3D gene

Transcripts
for SEMA3D gene

Expression
for SEMA3D gene

Orthologs
for SEMA3D gene

Paralogs
for SEMA3D gene

Genomic Variants
for SEMA3D gene

Disorders / Diseases
for SEMA3D gene

Publications
for SEMA3D gene

Intellectual Property
for SEMA3D gene

Products
for SEMA3D gene