Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SEMA3C Gene

Aliases for SEMA3C Gene

  • Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3C 2 3
  • Semaphorin-E 3 4
  • Sema E 3 4
  • SEMAE 3 4
  • Semaphorin-3C 3
  • Semaphorin E 3
  • SemE 3

External Ids for SEMA3C Gene

Previous Symbols for SEMA3C Gene

  • SEMAE

Summaries for SEMA3C Gene

GeneCards Summary for SEMA3C Gene

SEMA3C (Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3C) is a Protein Coding gene. Diseases associated with SEMA3C include allan-herndon-dudley syndrome. Among its related pathways are Axon guidance. GO annotations related to this gene include receptor activity and semaphorin receptor binding. An important paralog of this gene is SEMA4G.

UniProtKB/Swiss-Prot for SEMA3C Gene

  • Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity).

Gene Wiki entry for SEMA3C Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMA3C Gene

Genomics for SEMA3C Gene

Genomic Location for SEMA3C Gene

Start:
80,742,538 bp from pter
End:
80,922,359 bp from pter
Size:
179,822 bases
Orientation:
Minus strand

Genomic View for SEMA3C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEMA3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA3C Gene

Regulatory Elements for SEMA3C Gene

Proteins for SEMA3C Gene

  • Protein details for SEMA3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99985-SEM3C_HUMAN
    Recommended name:
    Semaphorin-3C
    Protein Accession:
    Q99985
    Secondary Accessions:
    • B4DRL8

    Protein attributes for SEMA3C Gene

    Size:
    751 amino acids
    Molecular mass:
    85207 Da
    Quaternary structure:
    • Interacts with PLXND1.

    Alternative splice isoforms for SEMA3C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEMA3C Gene

Proteomics data for SEMA3C Gene at MOPED

Post-translational modifications for SEMA3C Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn81, Asn123, Asn252, Asn268, Asn465, Asn585, and Asn586

Other Protein References for SEMA3C Gene

No data available for DME Specific Peptides for SEMA3C Gene

Domains for SEMA3C Gene

Gene Families for SEMA3C Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing
  • SEMA :Semaphorins

UniProtKB/Swiss-Prot:

SEM3C_HUMAN
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.:
    • Q99985
  • Contains 1 PSI domain.:
    • Q99985
  • Contains 1 Sema domain.:
    • Q99985
Family:
  • Belongs to the semaphorin family.:
    • Q99985
genes like me logo Genes that share domains with SEMA3C: view

Function for SEMA3C Gene

Molecular function for SEMA3C Gene

GENATLAS Biochemistry: semaphorin 3C,secreted in the developing nervous system,repellent of the nerve growth cone guidance
UniProtKB/Swiss-Prot Function: Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity).

LifeMap Function Summary for SEMA3C Gene

During embryonic development, SEMA3C as signaling molecule is secreted from the following cells

Gene Ontology (GO) - Molecular Function for SEMA3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0005515 protein binding --
GO:0030215 semaphorin receptor binding IEA --
genes like me logo Genes that share ontologies with SEMA3C: view
genes like me logo Genes that share phenotypes with SEMA3C: view

miRNA for SEMA3C Gene

miRTarBase miRNAs that target SEMA3C

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEMA3C Gene

Localization for SEMA3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA3C Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEMA3C Gene COMPARTMENTS Subcellular localization image for SEMA3C gene
Compartment Confidence
extracellular 5
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SEMA3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with SEMA3C: view

Pathways for SEMA3C Gene

SuperPathways for SEMA3C Gene

Superpath Contained pathways
1 Axon guidance
genes like me logo Genes that share pathways with SEMA3C: view

Pathways by source for SEMA3C Gene

1 KEGG pathway for SEMA3C Gene

Gene Ontology (GO) - Biological Process for SEMA3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001755 neural crest cell migration IEA --
GO:0001756 somitogenesis IEA --
GO:0001974 blood vessel remodeling IEA --
GO:0003151 outflow tract morphogenesis IEA --
GO:0003215 cardiac right ventricle morphogenesis IEA --
genes like me logo Genes that share ontologies with SEMA3C: view

Compounds for SEMA3C Gene

(1) Novoseek inferred chemical compound relationships for SEMA3C Gene

Compound -log(P) Hits PubMed IDs
tyrosine 0 2

(1) PharmGKB related drug/compound annotations for SEMA3C Gene

Drug/compound Annotation
irinotecan CA
genes like me logo Genes that share compounds with SEMA3C: view

Transcripts for SEMA3C Gene

Unigene Clusters for SEMA3C Gene

Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA3C Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for SEMA3C Gene

GeneLoc Exon Structure for
SEMA3C
ECgene alternative splicing isoforms for
SEMA3C

Expression for SEMA3C Gene

mRNA expression in normal human tissues for SEMA3C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SEMA3C Gene

SOURCE GeneReport for Unigene cluster for SEMA3C Gene Hs.269109

mRNA Expression by UniProt/SwissProt for SEMA3C Gene

Q99985-SEM3C_HUMAN
Tissue specificity: Expressed intensely in the heart, skeletal muscle, colon, small intestine, ovary, testis, and prostate. Faint expression ubiquitously among other organs, including brain
genes like me logo Genes that share expressions with SEMA3C: view

Orthologs for SEMA3C Gene

This gene was present in the common ancestor of animals.

Orthologs for SEMA3C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEMA3C 36
  • 99.69 (n)
  • 99.87 (a)
SEMA3C 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SEMA3C 36
  • 92.37 (n)
  • 95.87 (a)
SEMA3C 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEMA3C 36
  • 92.36 (n)
  • 97.47 (a)
SEMA3C 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sema3c 36
  • 88.15 (n)
  • 97.07 (a)
Sema3c 16
Sema3c 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEMA3C 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEMA3C 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sema3c 36
  • 88.46 (n)
  • 96.8 (a)
chicken
(Gallus gallus)
Aves SEMA3C 36
  • 81.45 (n)
  • 89.21 (a)
SEMA3C 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEMA3C 37
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sema3c 36
  • 76.43 (n)
  • 83.29 (a)
Str.7048 36
zebrafish
(Danio rerio)
Actinopterygii sema3c 36
  • 67.23 (n)
  • 71.59 (a)
sema3c 37
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sema-2a 38
  • 31 (a)
Species with no ortholog for SEMA3C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEMA3C Gene

ENSEMBL:
Gene Tree for SEMA3C (if available)
TreeFam:
Gene Tree for SEMA3C (if available)

Paralogs for SEMA3C Gene

genes like me logo Genes that share paralogs with SEMA3C: view

Variants for SEMA3C Gene

Sequence variations from dbSNP and Humsavar for SEMA3C Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs765764 -- 80,879,106(-) ATCCT(C/T)TCCTC intron-variant
rs765765 -- 80,879,067(-) GGGTT(C/T)TTCAC intron-variant
rs767185 -- 80,855,873(-) GAGCT(G/T)CATGT intron-variant
rs767732 -- 80,877,198(+) ATTGA(C/T)AATAT intron-variant
rs767733 -- 80,876,818(+) AATAC(A/G)TATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEMA3C Gene

Variant ID Type Subtype PubMed ID
nsv888512 CNV Loss 21882294
nsv888524 CNV Gain 21882294
esv274214 CNV Insertion 20981092
esv270195 CNV Insertion 20981092
esv2434401 CNV Deletion 19546169
esv3931 CNV Deletion 18987735
esv2673014 CNV Deletion 23128226

Relevant External Links for SEMA3C Gene

HapMap Linkage Disequilibrium report
SEMA3C

Disorders for SEMA3C Gene

(1) University of Copenhagen DISEASES for SEMA3C Gene

(4) Novoseek inferred disease relationships for SEMA3C Gene

Disease -log(P) Hits PubMed IDs
congenital heart disease 39.4 1
rheumatoid arthritis 16.8 1
tumors 4.74 2
cancer 0 1

Relevant External Links for SEMA3C

Genetic Association Database (GAD)
SEMA3C
genes like me logo Genes that share disorders with SEMA3C: view

No data available for UniProtKB/Swiss-Prot for SEMA3C Gene

Publications for SEMA3C Gene

  1. Identification of human semaphorin E gene expression in rheumatoid synovial cells by mRNA differential display. (PMID: 9168980) Mangasser-Stephan K. … Hanselmann R.G. (Biochem. Biophys. Res. Commun. 1997) 2 3 23
  2. Identification of semaphorin E as a non-MDR drug resistance gene of human cancers. (PMID: 9405678) Yamada T. … Hirohashi S. (Proc. Natl. Acad. Sci. U.S.A. 1997) 3 4 23
  3. Increased prevalence of semaphorin 3C, a repellent of sympathetic nerve fibers, in the synovial tissue of patients with rheumatoid arthritis. (PMID: 15077297) Miller L.E. … Straub R.H. (Arthritis Rheum. 2004) 3 23
  4. Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. (PMID: 7748561) PA1schel A.W. … Betz H. (Neuron 1995) 2 3
  5. GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling. (PMID: 19666519) Kodo K. … Yamagishi H. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23

Products for SEMA3C Gene

Sources for SEMA3C Gene

Back to Top

Content