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SEMA3C Gene

protein-coding   GIFtS: 64
GCID: GC07M080371

Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain,...


(Previous symbol: SEMAE)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted,
(Semaphorin) 3C1 2
     Semaphorin E2
SEMAE1 2 3     semaphorin-3C2
Sema E2 3     semaphorin-E2
SemE2     Semaphorin-E3

External Ids:    HGNC: 107251   Entrez Gene: 105122   Ensembl: ENSG000000752237   OMIM: 6026455   UniProtKB: Q999853   

Export aliases for SEMA3C gene to outside databases

Previous GC identifers: GC07M078907 GC07M079970 GC07M079983 GC07M080016 GC07M080209 GC07M074974


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SEMA3C Gene:
SEMA3C (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C) is a protein-coding gene. Diseases associated with SEMA3C include allan-herndon-dudley syndrome, and fainting. GO annotations related to this gene include semaphorin receptor binding and receptor activity. An important paralog of this gene is SEMA4F.

UniProtKB/Swiss-Prot: SEM3C_HUMAN, Q99985
Function: Binds to plexin family members and plays an important role in the regulation of developmental processes.
Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons,
and thereby plays an important role in axon growth and axon guidance (By similarity)

Gene Wiki entry for SEMA3C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEMA3C gene promoter:
         AML1a   ATF-2   AREB6   Pax-3   POU2F1   GCNF-1   POU2F1a   POU2F1b   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SEMA3C promoter sequence
   Search Chromatin IP Primers for SEMA3C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEMA3C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21-q31   Ensembl cytogenetic band:  7q21.11   HGNC cytogenetic band: 7q21-q31

SEMA3C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA3C gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M080371:  view genomic region     (about GC identifiers)

Start:
80,371,854 bp from pter      End:
80,551,675 bp from pter
Size:
179,822 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 79,703,271-79,880,104     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SEM3C_HUMAN, Q99985 (See protein sequence)
Recommended Name: Semaphorin-3C precursor  
Size: 751 amino acids; 85207 Da
Subunit: Interacts with PLXND1 (By similarity)

Explore the universe of human proteins at neXtProt for SEMA3C: NX_Q99985

Explore proteomics data for SEMA3C at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn81, Asn123, Asn252, Asn268, Asn465, Asn585, Asn586
  • Modification sites at PhosphoSitePlus

  • See SEMA3C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006370.1  
    ENSEMBL proteins: 
     ENSP00000265361   ENSP00000411193   ENSP00000393825   ENSP00000395398   ENSP00000399891  
     ENSP00000445649   ENSP00000438258  

    SEMA3C Human Recombinant Protein Products:

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    Novus Biologicals SEMA3C Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEMA3C

    SEMA3C Antibody Products:

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    Cloud-Clone Corp. CLIAs for SEMA3C


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing
    SEMA: Semaphorins

    Selected InterPro protein domains (see all 8):
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR027231 Semaphorin
     IPR001627 Semap_dom
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q99985

    ProtoNet protein and cluster: Q99985

    2 Blocks protein domains:
    IPB001627 Semaphorin/CD100 antigen
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: SEM3C_HUMAN, Q99985
    Similarity: Belongs to the semaphorin family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 PSI domain
    Similarity: Contains 1 Sema domain


    SEMA3C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEM3C_HUMAN, Q99985
    Function: Binds to plexin family members and plays an important role in the regulation of developmental processes.
    Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons,
    and thereby plays an important role in axon growth and axon guidance (By similarity)

         Genatlas biochemistry entry for SEMA3C:
    semaphorin 3C,secreted in the developing nervous system,repellent of the nerve growth cone guidance

         Summary: 
    During embryonic development, SEMA3C as signaling molecule is secreted from the following cells:
                
    Heart: Cardiomyocytes (Outflow Tract)

    It affects the following cells:
    Heart: Neural Crest Outflow Tract Cells (Outflow Tract)
    Head Mesenchyme: Cardiac Neural Crest Cells (Branchial Arch 3,4,6)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----
    GO:0030215semaphorin receptor binding IEA--
         
    SEMA3C for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SEMA3C:
     Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sema3c):
     cardiovascular system  cellular  embryogenesis  mortality/aging  nervous system 
     pigmentation 

    SEMA3C for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEMA3C
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEMA3C
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEMA3C

    miRNA
    Products:
        
    miRTarBase miRNAs that target SEMA3C:
    hsa-mir-375 (MIRT019941), hsa-mir-98-5p (MIRT027705), hsa-mir-374b-5p (MIRT016050)

    Block miRNA regulation of human, mouse, rat SEMA3C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEMA3C (see all 26):
    hsa-miR-548j hsa-miR-181c hsa-miR-548i hsa-miR-449c* hsa-miR-767-5p hsa-miR-487a hsa-miR-485-3p hsa-miR-501-3p
    SwitchGear 3'UTR luciferase reporter plasmidSEMA3C 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SEMA3C
    Predesigned siRNA for gene silencing in human, mouse, rat SEMA3C

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEMA3C (NM_006379)
    Sino Biological Human cDNA Clone for SEMA3C
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA3C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA3C

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SEM3C_HUMAN, Q99985: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0016020membrane IEA--

    SEMA3C for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SEMA3C About    
    See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Axon guidance

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for SEMA3C):
        Axon guidance


    SEMA3C for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEMA3C
    Interactions:

        GeneGlobe Interaction Network for SEMA3C

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for SEMA3C (Q999853 ENSP000002653614) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NRP2O604623, ENSP000003535824I2D: score=1 STRING: ENSP00000353582
    NRP1O147863, ENSP000002653714I2D: score=2 STRING: ENSP00000265371
    PLXND1ENSP000003171284STRING: ENSP00000317128
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001755neural crest cell migration IEA--
    GO:0001756somitogenesis IEA--
    GO:0001974blood vessel remodeling IEA--
    GO:0003151outflow tract morphogenesis IEA--
    GO:0003215cardiac right ventricle morphogenesis IEA--

    SEMA3C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEMA3C (SEM3C)

    1 Novoseek inferred chemical compound relationship for SEMA3C gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 0 3 12598331 (1), 17064702 (1)



    SEMA3C for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SEMA3C gene: 
    NM_006379.3  

    Unigene Cluster for SEMA3C:

    Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
    Hs.269109  [show with all ESTs]
    Unigene Representative Sequence: NM_006379
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265361(uc003uhj.3 uc011kgw.2 uc011kgx.1) ENST00000419255
    ENST00000458729 ENST00000475955 ENST00000459652 ENST00000411788 ENST00000427167
    ENST00000487621 ENST00000470581 ENST00000544525 ENST00000536800

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SEMA3C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEMA3C (see all 26):
    hsa-miR-548j hsa-miR-181c hsa-miR-548i hsa-miR-449c* hsa-miR-767-5p hsa-miR-487a hsa-miR-485-3p hsa-miR-501-3p
    SwitchGear 3'UTR luciferase reporter plasmidSEMA3C 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SEMA3C
    Predesigned siRNA for gene silencing in human, mouse, rat SEMA3C
    Clone
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    GenScript: all cDNA clones in your preferred vector: SEMA3C (NM_006379)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA3C
    Primer
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    OriGene qPCR primer pairs and template standards for SEMA3C
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEMA3C
      QuantiTect SYBR Green Assays in human, mouse, rat SEMA3C
      QuantiFast Probe-based Assays in human, mouse, rat SEMA3C

    Additional mRNA sequence: 

    AB000220.1 AF086506.1 AK299322.1 AK304294.1 AK312478.1 BC030690.1 D32000.1 

    5 DOTS entries:

    DT.312951  DT.100779533  DT.95143680  DT.97819328  DT.40289419 

    Selected AceView cDNA sequences (see all 170):

    CB131490 AL603108 AL135601 BP358106 BP356945 BM977196 AL698797 AI241943 
    AI581420 AU119424 CB158967 CB128336 AL119033 AV734397 AW338965 AI491966 
    BU193791 BP359535 BP356636 AI090512 CD370209 AI866867 BQ008235 AL709637 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SEMA3C    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:                          -     -                                                                 -                                             
    SP2:                                                                                                                          -                     
    SP3:                          -                                                                                                                     
    SP4:                                                                                                                                                


    ECgene alternative splicing isoforms for SEMA3C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SEMA3C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAATTCCC
    SEMA3C Expression
    About this image


    SEMA3C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
             Cardiac Neural Crest Cells Cardiac Neural Crest
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Neural Crest Outflow Tract Cells Outflow Tract
             Aorticopulmonary Septum
     
     Head Mesenchyme (Muscoskeletal System)
             Cardiac Neural Crest Cells Branchial Arch 3,4,6
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Adult Endothelial Cells Blood Brain Barrier
             Midbrain tegmentum
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
    SEMA3C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEMA3C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.269109

    UniProtKB/Swiss-Prot: SEM3C_HUMAN, Q99985
    Tissue specificity: Expressed intensely in the heart, skeletal muscle, colon, small intestine, ovary, testis, and
    prostate. Faint expression ubiquitously among other organs, including brain

        Custom PCR Arrays for SEMA3C
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SEMA3C gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sema3c1 , 5 sema domain, immunoglobulin domain (Ig), short basic more1, 5 88.15(n)1
    97.07(a)1
      5 (7.99 cM)5
    203481  NM_013657.51  NP_038685.31 
     175742815 
    chicken
    (Gallus gallus)
    Aves SEMA3C1 sema domain, immunoglobulin domain (Ig), short basic more 81.45(n)
    89.21(a)
      374090  NM_204243.1  NP_989574.1 
    lizard
    (Anolis carolinensis)
    Reptilia SEMA3C6
    sema domain, immunoglobulin domain (Ig), short bas...
    89(a)
    1 ↔ 1
    5(92782560-93049234)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.70482 Transcribed sequence with moderate similarity to protein more 80.71(n)    AL868189.2 
    zebrafish
    (Danio rerio)
    Actinopterygii sema3c1 semaphorin 3c 67.23(n)
    71.59(a)
      553130  XM_687755.5  XP_692847.3 


    ENSEMBL Gene Tree for SEMA3C (if available)
    TreeFam Gene Tree for SEMA3C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for SEMA3C gene
    SEMA4F2  SEMA3E2  SEMA4B2  SEMA4C2  SEMA3F2  SEMA4A2  SEMA4D2  SEMA4G2  
    SEMA3A2  SEMA3G2  SEMA3D2  
    18 SIMAP similar genes for SEMA3C using alignment to 7 protein entries:     SEM3C_HUMAN (see all proteins):
    SEMA3F    SEMA3A    SEMA3E    SEMA3D    SEMA3B    SEMA3G
    SEMA5B    SEMA6D    SEMA4C    SEMA6A    SEMA4B    SEMA4D
    SEMA4D variant protein    SEMA5A    SEMA4G    SEMA4A    DKFZp686D04248    SEMA7A

    SEMA3C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SEMA3C (see all 3554)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1437014191,2
    C--80371362(+) ACCACA/GTAAAA 1 -- ds50010--------
    rs1510440571,2
    C--80371403(+) CTTGTA/GTAGCA 1 -- ds50010--------
    rs1899172101,2
    --80371414(+) AAGGAC/GGGCAG 1 -- ds50010--------
    rs1495736511,2
    C--80371514(+) TGTAT-/GTTCTT 1 -- ds50010--------
    rs1996021251,2
    C--80371515(+) GTATT-/A/GTCTTC 1 -- ds50010--------
    rs19499701,2
    C,F,O,A,H--80371524(+) TCCAAT/CGTAGA 1 -- ds500195Minor allele frequency- C:0.03NS EA PA EU CA WA NA CSA 4730
    rs1411916031,2
    --80371689(+) GGGAGA/GGCTTC 1 -- ds50010--------
    rs104998631,2
    C,F,A,H--80371694(+) AGCTTT/CATATG 1 -- ds500199Minor allele frequency- C:0.04NS EA PA EU CA WA NA CSA 5506
    rs1819659981,2
    --80371702(+) ATGTGC/TATTTT 1 -- ds50010--------
    rs1846852061,2
    --80371823(+) TAACCC/TTACAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SEMA3C (80371854 - 80551675 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SEMA3C:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2434401CNV Deletion19546169
    esv3931CNV Deletion18987735
    esv2673014CNV Deletion23128226
    esv270195CNV Insertion20981092
    esv274214CNV Insertion20981092
    nsv888512CNV Loss21882294
    nsv888524CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEMA3C
    DNA2.0 Custom Variant and Variant Library Synthesis for SEMA3C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602645    OMIM disorders: --

    Selected diseases for SEMA3C (see all 24):    
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    allan-herndon-dudley syndrome    fainting    pancreatic endocrine tumors    malignant pleural mesothelioma
    malignant glioma    endometriosis    labyrinthitis    lung adenocarcinoma
    infertility    rheumatoid arthritis    arthritis    hepatitis c virus
    hepatitis c    adenocarcinoma    pancreatitis    endotheliitis
    alzheimer's disease    hepatitis    lung cancer    prostate cancer

    1 disease from the University of Copenhagen DISEASES database for SEMA3C:
    Allan-Herndon-Dudley syndrome

    SEMA3C for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for SEMA3C gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    congenital heart disease 39.4 1 11688557 (1)
    rheumatoid arthritis 16.8 1 15077297 (1)
    tumors 4.74 2 15569615 (1), 19915008 (1)
    cancer 0 1 9405678 (1)

    Genetic Association Database (GAD): SEMA3C

    Export disorders for SEMA3C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SEMA3C gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with SEMA3C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of semaphorin E as a non-MDR drug resistance gene of human cancers. (PubMed id 9405678)1, 2, 9 Yamada T.... Hirohashi S. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. Identification of human semaphorin E gene expression in rheumatoid synovial cells by mRNA differential display. (PubMed id 9168980)1, 3, 9 Mangasser-Stephan K....Hanselmann R.G. (Biochem. Biophys. Res. Commun. 1997)
    3. Genome-wide association meta-analysis for total serum bilirubin levels. (PubMed id 19414484)1, 4 Johnson A.D.... Witteman J.C. (Hum. Mol. Genet. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. (PubMed id 7748561)1, 3 PA1schel A.W....Betz H. (Neuron 1995)
    6. The cleavage of semaphorin 3C induced by ADAMTS1 promotes cell migration. (PubMed id 19915008)1, 9 Esselens C....Arribas J. (J. Biol. Chem. 2010)
    7. Increased prevalence of semaphorin 3C, a repellent of sympathetic nerve fibers, in the synovial tissue of patients with rheumatoid arthritis. (PubMed id 15077297)1, 9 Miller L.E....Straub R.H. (Arthritis Rheum. 2004)
    8. GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling. (PubMed id 19666519)1, 9 Kodo K.... Yamagishi H. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    9. Semaphorin 3C is a novel adipokine linked to extracellular matrix composition. (PubMed id 23666167)1 Mejhert N....RydAcn M. (Diabetologia 2013)
    10. Motoneuronal Sema3C is essential for setting stereotyped motor tract positioning in limb-derived chemotropic semaphorins. (PubMed id 22899844)1 Sanyas I....Castellani V. (Development 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10512 HGNC: 10725 AceView: SEMA3C Ensembl:ENSG00000075223 euGenes: HUgn10512
    ECgene: SEMA3C Kegg: 10512 H-InvDB: SEMA3C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SEMA3C Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SEMA3C Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SEMA3C gene:
    Search GeneIP for patents involving SEMA3C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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