SEMA3C Gene

Aliases
for SEMA3C gene

Previous GC identifers: GC07M078907 GC07M079970 GC07M079983 GC07M080016 GC07M080209 GC07M074974

Summaries
for SEMA3C gene

Genomic Views
for SEMA3C gene

RefSeq DNA sequence:

NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  

SwitchGear Promoter luciferase reporter plasmids (see all 3): SEMA3C promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA3C

SEMA3C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M080371:  view genomic region     (about GC identifiers)

Proteins
for SEMA3C gene

Explore the universe of human proteins at neXtProt for SEMA3C: NX_Q99985

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for SEMA3C (Semaphorin 3C)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: SEMA3C OriGene Custom Protein Services for SEMA3C
	GenScript Custom Purified and Recombinant Proteins Services for SEMA3C
	Novus Biologicals SEMA3C Protein Novus Biologicals SEMA3C Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SEMA3C

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for SEMA3C (Semaphorin 3C)
	Browse OriGene Antibodies OriGene Custom Antibody Services for SEMA3C
	GenScript Custom Superior Antibodies Services for SEMA3C
	Novus Biologicals SEMA3C Antibodies
	Search for Antibodies for SEMA3C at Abcam
	Uscn Antibodies for SEMA3C
	ThermoFisher Antibodies for SEMA3C

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SEMA3C
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SEMA3C

Protein Domains /
Families
for SEMA3C gene

ProtoNet protein and cluster: Q99985

Function
for SEMA3C gene

miRNA Products:		OriGene 3'-UTR Clone: SEMA3C Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA3C
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA3C (see all 26):
		hsa-miR-548j hsa-miR-181c hsa-miR-548i hsa-miR-449c* hsa-miR-767-5p hsa-miR-487a hsa-miR-485-3p hsa-miR-501-3p
		SwitchGear 3'UTR luciferase reporter plasmid: SEMA3C 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA3C (see all 7) OriGene shRNA RFP: SEMA3C OriGene siRNA: SEMA3C
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA3C

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SEMA3C

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA3C (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA3C OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SEMA3C (NM_006379)
		Sino Biological Human cDNA Clone for SEMA3C
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA3C
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA3C

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SEMA3C
		Search LifeMap BioReagents cell lines for SEMA3C

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3C

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Sema3c)

Pathways & Interactions
for SEMA3C gene

	Super-pathway	contained gene-specific pathways
1	Axon guidance	Axon guidance 1.00

1         Kegg Pathway  (Kegg details for SEMA3C)

Axon guidance

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

Drugs & Compounds
for SEMA3C gene

Transcripts
for SEMA3C gene

Expression
for SEMA3C gene

SEMA3C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGAATTCCC

6 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	Head MesenchymeBranchial Arch 3,4,6Cardiac Neural Crest Cells			Neural Crest
	HeartOutflow TractNeural Crest Outflow Tract Cells			Neural Crest
	Neural CrestCardiac Neural CrestCardiac Neural Crest Cells			Neural Crest
	HeartOutflow TractCardiomyocytes			Myocardium
	BrainBlood Brain BarrierAdult Endothelial Cells			Blood Brain Barrier, Endothelium
	KidneyUreteric Bud			Kidney
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 4 LifeMap Cells
	Name			Category
	PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)			Adipose, Bone, Cartilage
	PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
	Dorsal forebrain-like neurons (Generation of midbra...)			Brain
	Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEMA3C Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEMA3C
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA3C
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA3C

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3C

Orthologs
for SEMA3C gene

Paralogs
for SEMA3C gene

Paralogs for SEMA3C gene

SEMA4F²  SEMA3E²  SEMA4B²  SEMA3F²  SEMA4C²  SEMA4A²  SEMA4G²  SEMA4D²  

SEMA3A²  SEMA3G²  SEMA3D²  

18/19 SIMAP similar genes for SEMA3C using alignment to 7 protein entries:     SEM3C_HUMAN (see all proteins) (see all similar genes):

SEMA3F    SEMA3A    SEMA3E    SEMA3D    SEMA3B    SEMA3G

SEMA5B    SEMA6B    SEMA6D    SEMA4C    SEMA6A    SEMA4B

SEMA4D    SEMA4D variant protein    SEMA5A    SEMA4G    SEMA4A    DKFZp686D04248

SEMA3C for paralogs           About GeneDecksing

Genomic Variants
for SEMA3C gene

10/2999 NCBI SNPs in SEMA3C are shown (see all 2999)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1437014191,2		--	80371362(+)	ACCACA/GTAAAA	1	--	ds5001		0	--	--	--	--
rs1510440571,2		--	80371403(+)	CTTGTA/GTAGCA	1	--	ds5001		0	--	--	--	--
rs1899172101,2		--	80371414(+)	AAGGAC/GGGCAG	1	--	ds5001		0	--	--	--	--
rs1495736511,2	C,	--	80371514(+)	TGTAT-/GTTCTT	1	--	ds5001		0	--	--	--	--
rs19499701,2	C,F,O,A,H,	--	80371524(+)	TCCAAT/CGTAGA	1	--	ds5001		95		NS EA PA EU CA WA NA CSA	4730
rs1411916031,2		--	80371689(+)	GGGAGA/GGCTTC	1	--	ds5001		0	--	--	--	--
rs104998631,2	C,F,A,H,	--	80371694(+)	AGCTTT/CATATG	1	--	ds5001		99		NS EA PA EU CA WA NA CSA	5506
rs1819659981,2		--	80371702(+)	ATGTGC/TATTTT	1	--	ds5001		0	--	--	--	--
rs1846852061,2		--	80371823(+)	TAACCC/TTACAT	1	--	ds5001		0	--	--	--	--
rs19183751,2	C,F,O,A,H,	--	80371827(+)	CCTACG/ATTAAA	1	--	ds5001		18		NS EA NA WA CSA	1450

HapMap Linkage Disequilibrium report for SEMA3C (80371854 - 80551675 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SEMA3C
     1 CNV: 100000
     1 Indel: 41634

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEMA3C

DNA2.0 Custom Variant and Variant Library Synthesis for SEMA3C

Disorders / Diseases
for SEMA3C gene

20 diseases for SEMA3C

4 Novoseek disease relationships for SEMA3C gene    About this table

Publications
for SEMA3C gene

PubMed articles for SEMA3C gene, integrated from 9 sources (see all 44): (articles sorted by number of sources associating them with SEMA3C)

Utopia: connect your pdf to the dynamic world of online information

1. Identification of semaphorin E as a non-MDR drug resistance gene of human cancers. (PubMed id 9405678)^{1, 2, 9} Yamada T.... Hirohashi S. (1997)
2. Identification of human semaphorin E gene expression in rheumatoid synovial cells by mRNA differential display. (PubMed id 9168980)^{1, 3, 9} Mangasser-Stephan K....Hanselmann R.G. (1997)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
4. Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. (PubMed id 7748561)^{1, 3} Puschel A.W....Betz H. (1995)
5. The cleavage of semaphorin 3C induced by ADAMTS1 prom otes cell migration. (PubMed id 19915008)^{1, 9} Esselens C....Arribas J. (2010)
6. Increased prevalence of semaphorin 3C, a repellent of sympathetic nerve fibers, in the synovial tissue of patients with rheumatoid arthritis. (PubMed id 15077297)^{1, 9} Miller L.E....Straub R.H. (2004)
7. GATA6 mutations cause human cardiac outflow tract def ects by disrupting semaphorin-plexin signaling. (PubMed id 19666519)^{1, 9} Kodo K....Yamagishi H. (2009)
8. Motoneuronal Sema3C is essential for setting stereotyp ed motor tract positioning in limb-derived chemotropic semaphorins. (PubMed id 22899844)¹ Sanyas I....Castellani V. (2012)
9. Genome-wide association meta-analysis for total serum bilirubin levels. (PubMed id 19414484)¹ Johnson A.D....Witteman J.C. (2009)
10. Increased class 3 semaphorin expression modulates the invasive and adhesive properties of prostate cancer cells. (PubMed id 17390026)¹ Herman J.G. and Meadows G.G. (2007)

External Searches for SEMA3C gene

Genome Databases showing SEMA3C gene

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Specialized Databases showing SEMA3C gene

Products
for SEMA3C gene