Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEMA3B Gene

protein-coding   GIFtS: 61
GCID: GC03P050304

Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain,...


(Previous symbol: SEMAA)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted,
(Semaphorin) 3B1 2
     SemA2
SEMAA1 2 3     semaV2
SEMA52 3 5     Semaphorin A2
Sema A(V)2 3     semaphorin-3B2
Sema V2 3     semaphorin-V2
LUCA-12     Semaphorin-V3

External Ids:    HGNC: 107241   Entrez Gene: 78692   Ensembl: ENSG000000121717   OMIM: 6012815   UniProtKB: Q132143   

Export aliases for SEMA3B gene to outside databases

Previous GC identifers: GC03M049672 GC03M049841 GC03P050159 GC03P050265 GC03P050281


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEMA3B Gene:
The semaphorin/collapsin family of molecules plays a critical role in the guidance of growth cones during neuronal
development. The secreted protein encoded by this gene family member is important in axonal guidance and has been
shown to act as a tumor suppressor by inducing apoptosis. (provided by RefSeq, Jul 2008)

GeneCards Summary for SEMA3B Gene: 
SEMA3B (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B) is a protein-coding gene. Diseases associated with SEMA3B include phencyclidine abuse, and clear cell renal cell carcinoma. GO annotations related to this gene include receptor activity.

UniProtKB/Swiss-Prot: SEM3B_HUMAN, Q13214
Function: Inhibits axonal extension by providing local signals to specify territories inaccessible for growing
axons (By similarity)

Gene Wiki entry for SEMA3B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEMA3B gene promoter:
         GR   GR-beta   Lmo2   Olf-1   Nkx2-5   CUTL1   LCR-F1   GATA-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SEMA3B promoter sequence
   Search SABiosciences Chromatin IP Primers for SEMA3B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

SEMA3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA3B gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P050304:  view genomic region     (about GC identifiers)

Start:
50,304,990 bp from pter      End:
50,314,977 bp from pter
Size:
9,988 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SEM3B_HUMAN, Q13214 (See protein sequence)
Recommended Name: Semaphorin-3B precursor  
Size: 749 amino acids; 83122 Da
Subcellular location: Secreted (By similarity). Endoplasmic reticulum. Note=Accumulates in the endoplasmic
reticulum
Sequence caution: Sequence=AAC02731.1; Type=Erroneous gene model prediction;
Secondary accessions: Q6GU46 Q8TB71 Q8TDV7 Q93018 Q96GX0
Alternative splicing: 2 isoforms:  Q13214-1   Q13214-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEMA3B: NX_Q13214

Explore proteomics data for SEMA3B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13214

  • SEMA3B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SEMA3B Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001005914.1  NP_004627.1  

    Human Recombinant Protein Products for SEMA3B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SEMA3B
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SEMA3B
    GenScript Custom Purified and Recombinant Proteins Services for SEMA3B
    Novus Biologicals SEMA3B Protein
    Novus Biologicals SEMA3B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEMA3B 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0016020membrane IEA--

    SEMA3B for ontologies           About GeneDecksing



    SEMA3B Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for SEMA3B 
    OriGene Antibodies for SEMA3B
    OriGene Custom Antibody Services for SEMA3B
    GenScript Custom Superior Antibodies Services for SEMA3B
    Novus Biologicals SEMA3B Antibodies
    Abcam antibodies for SEMA3B
    Cloud-Clone Corp. Antibodies for SEMA3B 
    ThermoFisher Antibodies for SEMA3B
    LSBio Antibodies in human, mouse, rat for SEMA3B 

    Assay Products for SEMA3B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SEMA3B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SEMA3B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SEMA3B 
    Cloud-Clone Corp. CLIAs for SEMA3B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    SEMA: Semaphorins

    5/9 InterPro protein domains (see all 9):
     IPR007110 Ig-like_dom
     IPR003659 Plexin-like
     IPR003599 Ig_sub
     IPR002165 Plexin_repeat
     IPR016201 Plexin-like_fold

    Graphical View of Domain Structure for InterPro Entry Q13214

    ProtoNet protein and cluster: Q13214

    2 Blocks protein domains:
    IPB001627 Semaphorin/CD100 antigen
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: SEM3B_HUMAN, Q13214
    Similarity: Belongs to the semaphorin family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 PSI domain
    Similarity: Contains 1 Sema domain


    SEMA3B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEM3B_HUMAN, Q13214
    Function: Inhibits axonal extension by providing local signals to specify territories inaccessible for growing
    axons (By similarity)

         Genatlas biochemistry entry for SEMA3B:
    semaphorin 3B,secreted,expressed in neuronal and non neuronal tissues,repellent of the nerve growth cone guidance

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
         
    SEMA3B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SEMA3B:
     Increased S DNA content, incre 

         2 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Sema3b):
     nervous system  normal 

    SEMA3B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SEMA3B: Sema3btm1.2Brd Sema3btm1Cast Sema3btm1Mom

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SEMA3B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SEMA3B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEMA3B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEMA3B 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA3B
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA3B (see all 15):
    hsa-miR-569 hsa-miR-137 hsa-miR-767-3p hsa-miR-181c hsa-miR-27a hsa-miR-513a-5p hsa-miR-222 hsa-miR-181a
    SwitchGear 3'UTR luciferase reporter plasmidSEMA3B 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SEMA3B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA3B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SEMA3B
    Sirion Biotech Customized adenovirus for overexpression of SEMA3B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SEMA3B (see all 9)
    OriGene ORF clones in mouse, rat for SEMA3B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SEMA3B (NM_004636)
    Sino Biological Human cDNA Clone for SEMA3B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA3B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA3B
    Sirion Biotech Customized lentivirus for stable overexpression of SEMA3B 
                         Customized lentivirus expression plasmids for stable overexpression of SEMA3B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SEMA3B
    Search LifeMap BioReagents cell lines for SEMA3B
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SEMA3B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Neuroscience
    Neuroscience
    2Axon guidance
    Axon guidance

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SEMA3B
        Neuroscience



    1         Kegg Pathway  (Kegg details for SEMA3B):
        Axon guidance


    SEMA3B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SEMA3B

    3 Interacting proteins for SEMA3B (Q132143) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NRP1O147863I2D: score=1 
    NRP2O604623I2D: score=1 
    SEMA3AQ145633I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007267cell-cell signaling TAS8633026
    GO:0007411axon guidance TAS8633026

    SEMA3B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SEMA3B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEMA3B (SEM3B)

    4 Novoseek inferred chemical compound relationships for SEMA3B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 53.1 11 15273288 (2), 17010410 (1), 18793406 (1), 16621967 (1) (see all 7)
    5-aza-2'deoxycytidine 43.6 2 17452250 (1), 15704097 (1)
    tyrosine 15.8 1 15203206 (1)
    retinoic acid 10.9 2 12174360 (1), 17452250 (1)

    Search CenterWatch for drugs/clinical trials and news about SEMA3B / SEM3B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SEMA3B gene (2 alternative transcripts): 
    NM_001005914.1  NM_004636.2  

    Unigene Cluster for SEMA3B:

    Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
    Hs.82222  [show with all ESTs]
    Unigene Representative Sequence: AB209322
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419213 ENST00000454939(uc003cyv.3 uc003cyw.3 uc010hli.3)
    ENST00000418948 ENST00000454314 ENST00000426144 ENST00000441915(uc003cyx.3)
    ENST00000456560(uc003cyy.3 uc011bdo.2) ENST00000439487 ENST00000434030
    ENST00000456210 ENST00000418576 ENST00000419007 ENST00000433753 ENST00000416295
    ENST00000316347(uc010hlh.1 uc003cyt.3 uc003cyu.3) ENST00000414456

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA3B
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA3B (see all 15):
    hsa-miR-569 hsa-miR-137 hsa-miR-767-3p hsa-miR-181c hsa-miR-27a hsa-miR-513a-5p hsa-miR-222 hsa-miR-181a
    SwitchGear 3'UTR luciferase reporter plasmidSEMA3B 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SEMA3B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA3B
    Clone
    Products:
         
    OriGene clones in human, mouse for SEMA3B (see all 9)
    OriGene ORF clones in mouse, rat for SEMA3B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SEMA3B (NM_004636)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA3B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA3B
    Sirion Biotech Customized lentivirus for stable overexpression of SEMA3B 
                         Customized lentivirus expression plasmids for stable overexpression of SEMA3B 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SEMA3B
    OriGene qSTAR qPCR primer pairs in human, mouse for SEMA3B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEMA3B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA3B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA3B

    Additional mRNA sequence: 

    AB083186.1 AB209322.1 AF217991.1 AK092182.1 AK293678.1 AK308875.1 BC009113.1 BC013975.2 
    BC024220.2 BC044602.1 U28369.1 

    19 DOTS entries:

    DT.100784366  DT.97859009  DT.97836288  DT.87017274  DT.87017280  DT.100819096  DT.91789262  DT.91745332 
    DT.95195655  DT.120882210  DT.91745333  DT.91745334  DT.95195707  DT.120882222  DT.91745341  DT.91990558 
    DT.95195661  DT.95195689  DT.95195698 

    24/269 AceView cDNA sequences (see all 269):

    AA284622 BM765879 BM547638 NM_004636 BM666635 BM702049 AK092182 BI825327 
    CB108075 CA444978 BQ446644 BQ940740 BC013975 AA480188 BF002376 CB051672 
    AX747395 BQ012491 CR603294 BF724980 BC024220 BF725238 BC009113 BQ026623 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for SEMA3B (see all 17)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^
    SP1:                                      -           -                             -     -     -                             -     -                           
    SP2:                                      -           -                             -     -     -                             -     -                           
    SP3:                                      -           -                             -     -     -                             -                                 
    SP4:                                      -           -                             -     -     -                                                               
    SP5:                                                                                -     -     -                             -     -                           

    ExUns: 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c · 16d ^ 17 ^ 18 ^ 19a · 19b · 19c · 19d · 19e
    SP1:              -                 -                                                               
    SP2:              -                 -                                                               
    SP3:              -                 -                                                               
    SP4:              -                 -                                                               
    SP5:              -                 -                                                               


    ECgene alternative splicing isoforms for SEMA3B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEMA3B expression in normal human tissues (normalized intensities)      SEMA3B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCGCCCGC
    SEMA3B Expression
    About this image


    SEMA3B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
             Olfactory Bulb   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Ventral Horn   
     
     Adrenal Gland (Endocrine System)
             Adrenal Cortex   
     
     Uncategorized (Uncategorized)
             PureStem Progenitor ES-154
     
     Placenta (Extraembryonic Tissues)

    See SEMA3B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEMA3B

    SOURCE GeneReport for Unigene cluster: Hs.82222

    UniProtKB/Swiss-Prot: SEM3B_HUMAN, Q13214
    Tissue specificity: Expressed abundantly but differentially in a variety of neural and nonneural tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including SEMA3B: 
              Lung Cancer in human mouse rat
              Neurotoxicity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SEMA3B
    OriGene qSTAR qPCR primer pairs in human, mouse for SEMA3B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEMA3B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA3B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA3B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SEMA3B gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sema3b1 , 5 sema domain, immunoglobulin domain (Ig), short basic more1, 5 83.13(n)1
    88.65(a)1
      9 (58.31 cM)5
    203471  NM_001042779.11  NP_001036244.11 
     1075976745 
    chicken
    (Gallus gallus)
    Aves SEMA3B1 sema domain, immunoglobulin domain (Ig), short basic more 77.22(n)
    78.41(a)
      426234  XM_423897.3  XP_423897.3 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-106g4.21 si:ch211-106g4.2 63.87(n)
    65.29(a)
      567064  NM_001128346.1  NP_001121818.1 


    ENSEMBL Gene Tree for SEMA3B (if available)
    TreeFam Gene Tree for SEMA3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEMA3B gene
    16 SIMAP similar genes for SEMA3B using alignment to 2 protein entries:     SEM3B_HUMAN (see all proteins):
    SEMA3A    SEMA3D    SEMA3F    SEMA3C    SEMA3E    SEMA3G
    SEMA6D    SEMA4C    SEMA6A    SEMA4D    SEMA4D variant protein    DKFZp686D04248
    SEMA4A    SEMA4F    SEMA4B    SEMA4G

    SEMA3B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/249 SNPs in SEMA3B are shown (see all 249)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0142224
    A non-small cell lung cancer cell line4--see VAR_0142222 D H mis40--------
    VAR_0142214
    A non-small cell lung cancer cell line4--see VAR_0142212 R C mis40--------
    rs20712031,2,4
    C,F,HA non-small cell lung cancer cell line4 --50244256(-) CCCCAG/ATGGGC 4 /T /I mis1 ese318Minor allele frequency- A:0.30EA NS NA WA EU 4131
    rs1413815991,2
    --50235512(+) ATCCTC/TGAGGA 2 -- us2k10--------
    rs1167334811,2
    F--50235553(+) TGACCT/CTGCTC 2 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1143717701,2
    F--50235763(+) TAGTCC/TTTTTG 2 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1474298581,2
    --50235771(+) TTGGCA/TGGGGG 2 -- us2k10--------
    rs755126141,2
    --50235810(+) GGCGGG/TGGCGG 2 -- us2k10--------
    rs1117022961,2
    C--50235832(+) ATACCG/ATTTCC 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1917977941,2
    --50235858(+) TGGAGC/GAAGGT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SEMA3B (50304990 - 50314977 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for SEMA3B (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv5132n71CNV Loss21882294
    nsv523662CNV Loss19592680
    nsv876770CNV Loss21882294
    dgv5131n71CNV Loss21882294
    nsv876769CNV Loss21882294
    dgv602n27CNV Loss19166990
    nsv834692CNV Loss17160897
    nsv470561CNV Loss18288195
    nsv834693CNV Loss17160897
    nsv460531CNV Loss19166990

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SEMA3B
    DNA2.0 Custom Variant and Variant Library Synthesis for SEMA3B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601281    OMIM disorders: --

    16 diseases for SEMA3B:    About MalaCards
    phencyclidine abuse    clear cell renal cell carcinoma    renal cell carcinoma    nasopharyngitis
    periodontitis    lung cancer    neuroblastoma    glioblastoma
    schizophrenia    endotheliitis    breast cancer    neuronitis
    ovarian cancer    prostate cancer    prostatitis    adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for SEMA3B:
    Phencyclidine abuse

    SEMA3B for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for SEMA3B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 45.9 8 15831529 (1), 14659031 (1), 18757406 (1), 12561429 (1) (see all 6)
    tumors 36.4 56 17452250 (5), 18458115 (5), 12561429 (4), 18922901 (4) (see all 15)
    nsclc 33.6 7 12810670 (5)
    cancer 13.1 3 18458115 (2)
    breast cancer 3.82 11 18922901 (4), 15273288 (3), 15985208 (1)
    metastasis 0 2 17010410 (1)
    carcinoma 0 3 17010410 (2)

    Genetic Association Database (GAD): SEMA3B
    Human Genome Epidemiology (HuGE) Navigator: SEMA3B (3 documents)

    Export disorders for SEMA3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEMA3B gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with SEMA3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns. (PubMed id 8633026)1, 2, 3 Sekido Y.... Minna J.D. (1996)
    2. Semaphorin 3B and 3F single nucleotide polymorphisms are associated with prostate cancer risk and poor prognosis. (PubMed id 19683737)1, 4, 9 Beuten J....Naylor S.L. (2009)
    3. The race associated allele of Semaphorin 3B (SEMA3B) T415I and its role in lung cancer in African-Americans and Latino-Americans. (PubMed id 15831529)1, 4, 9 Marsit C.J....Kelsey K.T. (2005)
    4. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. (PubMed id 11085536)1, 2 Lerman M.I. and Minna J.D. (2000)
    7. Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. (PubMed id 7748561)1, 3 Puschel A.W....Betz H. (1995)
    8. Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF165 antagonizes this effect. (PubMed id 15273288)1, 9 Castro-Rivera E....Minna J.D. (2004)
    9. Semaphorin-3B is an angiogenesis inhibitor that is inactivated by furin-like pro-protein convertases. (PubMed id 18757406)1, 9 Varshavsky A....Neufeld G. (2008)
    10. Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells. (PubMed id 18922901)1, 9 Castro-Rivera E....Minna J.D. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7869 HGNC: 10724 AceView: SEMA3B Ensembl:ENSG00000012171 euGenes: HUgn7869
    ECgene: SEMA3B Kegg: 7869 H-InvDB: SEMA3B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEMA3B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SEMA3B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEMA3B gene:
    Search GeneIP for patents involving SEMA3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SEMA3B   OriGene RNAi products in human, mouse, rat for SEMA3B  
     OriGene qPCR primer pairs and template standards for SEMA3B   OriGene Protein Over-expression Lysate for SEMA3B  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SEMA3B  
     OriGene qSTAR qPCR primer pairs in human, mouse for SEMA3B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SEMA3B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SEMA3B   OriGene Custom Protein Services for SEMA3B  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SEMA3B
     QIAGEN SeqTarget long-range PCR primers for resequencing SEMA3B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA3B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA3B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA3B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA3B
     GenScript Custom Purified and Recombinant Proteins Services for SEMA3B GenScript cDNA clones with any tag delivered in your preferred vector for SEMA3B
     GenScript Custom Assay Services for SEMA3B GenScript Custom Superior Antibodies Services for SEMA3B
     GenScript Custom overexpressing Cell Line Services for SEMA3B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for SEMA3B 

     Regulatory tfbs in SEMA3B promoter
     Search Chromatin IP Primers for SEMA3B
     RT2 qPCR Primer Assay in human, mouse, rat SEMA3B
     GNC Network for SEMA3B
     SABiosciences PCR Arrays including human, mouse, rat SEMA3B
     Search Tocris compounds for SEMA3B (SEM3B)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for SEMA3B
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SEMA3B antibodies
     SEMA3B proteins
     SEMA3B lysates
     Antibodies for SEMA3B
     See all of Abcam's Antibodies, Kits and Proteins for SEMA3B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SEMA3B
     Antibodies for SEMA3B
     ELISAs for SEMA3B
     CLIAs for SEMA3B
     Search LifeMap BioReagents cell lines for SEMA3B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3B
     SwitchGear 3'UTR luciferase reporter plasmids for SEMA3B
     SwitchGear Promoter luciferase reporter plasmids for SEMA3B
     ThermoFisher Antibodies for SEMA3B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA3B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SEMA3B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SEMA3B
    Customized:
     lentivirus for stable overexpression of SEMA3B
     lentivirus expression plasmids for stable overexpression of SEMA3B
     adenovirus for overexpression of SEMA3B
     LSBio Antibodies in human, mouse, rat for SEMA3B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SEMA3B gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4