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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SEMA3B Gene

protein-coding GIFtS: 59
GCID: GC03P050304

sema domain, immunoglobulin domain (Ig), short basic domain,...

(Previous symbol: SEMAA)

Explore 17 diseases affiliated with
SEMA3B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3B¹ ²		Sema V² ³
SEMAA¹ ² ³		Sema5¹
SEMA5² ³ ⁵		Semaphorin A²
LUCA-1¹ ²		Semaphorin-3B¹
SemA¹ ²		Semaphorin-V³
SemaV¹		Semaphorin-V³
Sema A(V)² ³

External Ids:	HGNC: 10724¹	Entrez Gene: 7869²	Ensembl: ENSG00000012171⁷	OMIM: 601281⁵	UniProtKB: Q13214³

Export aliases for SEMA3B gene to outside databases

Previous GC identifers: GC03M049672 GC03M049841 GC03P050159 GC03P050265 GC03P050281

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEMA3B:

The semaphorin/collapsin family of molecules plays a critical role in the guidance of growth cones during neuronal

development. The secreted protein encoded by this gene family member is important in axonal guidance and has been

shown to act as a tumor suppressor by inducing apoptosis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SEM3B_HUMAN, Q13214

Function: Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons

(By similarity)

Gene Wiki entry for SEMA3B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SEMA3B gene promoter:
GR GR-beta Lmo2 Olf-1 Nkx2-5 CUTL1 LCR-F1 GATA-1 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SEMA3B promoter sequence

Search SABiosciences Chromatin IP Primers for SEMA3B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEMA3B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.3

SEMA3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA3B gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P050304: view genomic region (about GC identifiers)

Start:	50,304,990 bp from pter	End:	50,314,977 bp from pter
Size:	9,988 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SEM3B_HUMAN, Q13214 (See protein sequence)

Recommended Name: Semaphorin-3B precursor

Size: 749 amino acids; 83122 Da

Subcellular location: Secreted (By similarity). Endoplasmic reticulum. Note=Accumulates in the endoplasmic reticulum

Sequence caution: Sequence=AAC02731.1; Type=Erroneous gene model prediction;

Secondary accessions: Q6GU46 Q8TB71 Q8TDV7 Q93018 Q96GX0

Alternative splicing: 2 isoforms: Q13214-1 Q13214-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEMA3B: NX_Q13214

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q13214

SEMA3B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001005914.1 NP_004627.1

Human Recombinant Protein Products for SEMA3B:

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	Novus Biologicals SEMA3B Protein Novus Biologicals SEMA3B Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SEMA3B

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005783	endoplasmic reticulum	IEA	--
GO:0016020	membrane	IEA	--

SEMA3B for ontologies About GeneDecksing

SEMA3B Antibody Products:

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	Uscn ELISAs and CLIAs for SEMA3B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SEMA3B for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR007110 Ig-like_dom

IPR003659 Plexin-like

IPR003599 Ig_sub

IPR002165 Plexin_repeat

IPR016201 Plexin-like_fold

Graphical View of Domain Structure for InterPro Entry Q13214

ProtoNet protein and cluster: Q13214

2 Blocks protein families:

IPB001627 Semaphorin/CD100 antigen

IPB003599 Immunoglobulin subtype

UniProtKB/Swiss-Prot: SEM3B_HUMAN, Q13214

Similarity: Belongs to the semaphorin family

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

Similarity: Contains 1 PSI domain

Similarity: Contains 1 Sema domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SEM3B_HUMAN, Q13214

Function: Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons

semaphorin 3B,secreted,expressed in neuronal and non neuronal tissues,repellent of the nerve growth cone guidance

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--

SEMA3B for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for SEMA3B:

Increased S DNA content, incre

2 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Sema3b):

nervous system

normal

SEMA3B for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for SEMA3B: Sema3b^tm1.2Brd Sema3b^tm1Cast Sema3b^tm1Mom

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SEMA3B

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SEMA3B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA3B
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA3B (see all 15):
		hsa-miR-569 hsa-miR-137 hsa-miR-767-3p hsa-miR-181c hsa-miR-27a hsa-miR-513a-5p hsa-miR-222 hsa-miR-181a

		SwitchGear 3'UTR luciferase reporter plasmid: SEMA3B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA3B (see all 7) OriGene shRNA RFP: SEMA3B OriGene siRNA: SEMA3B
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		Sirion Biotech Custom design and validation of potent shRNA sequences against SEMA3B

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SEMA3B
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA3B (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEMA3B (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SEMA3B (NM_004636)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA3B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA3B

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SEMA3B
		Search LifeMap BioReagents cell lines for SEMA3B
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3B

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Neuroscience

Neuroscience

1.00

Axon guidance

Axon guidance

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for SEMA3B

Neuroscience

1 Kegg Pathway (Kegg details for SEMA3B):

Axon guidance

SEMA3B for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SEMA3B

3 Interacting proteins for SEMA3B (Q13214³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NRP1	O14786³	I2D: score=1
NRP2	O60462³	I2D: score=1
SEMA3A	Q14563³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007267	cell-cell signaling	TAS	8633026
GO:0007411	axon guidance	TAS	8633026

SEMA3B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SEMA3B for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SEMA3B
4 Novoseek chemical compound relationships for SEMA3B gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
vegf	53.1	11	15273288 (2), 17010410 (1), 18793406 (1), 16621967 (1) (see all 7)
5-aza-2'deoxycytidine	43.6	2	17452250 (1), 15704097 (1)
tyrosine	15.8	1	15203206 (1)
retinoic acid	10.9	2	12174360 (1), 17452250 (1)

Search CenterWatch for drugs/clinical trials and news about SEMA3B / SEM3B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SEMA3B gene (2 alternative transcripts):

NM_001005914.1 NM_004636.2

Unigene Cluster for SEMA3B:

Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

Hs.82222 [show with all ESTs]

Unigene Representative Sequence: AB209322

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000419213 ENST00000454939(uc003cyv.3 uc003cyw.3 uc010hli.3)

ENST00000418948 ENST00000454314 ENST00000426144 ENST00000441915(uc003cyx.3)

ENST00000456560(uc003cyy.3 uc011bdo.2) ENST00000439487 ENST00000434030

ENST00000456210 ENST00000418576 ENST00000419007 ENST00000433753 ENST00000416295

ENST00000316347(uc010hlh.1 uc003cyt.3 uc003cyu.3) ENST00000414456

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SEMA3B Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEMA3B
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate SEMA3B (see all 15):
		hsa-miR-569 hsa-miR-137 hsa-miR-767-3p hsa-miR-181c hsa-miR-27a hsa-miR-513a-5p hsa-miR-222 hsa-miR-181a

		SwitchGear 3'UTR luciferase reporter plasmid: SEMA3B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEMA3B (see all 7) OriGene shRNA RFP: SEMA3B OriGene siRNA: SEMA3B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEMA3B
		Sirion Biotech Custom design and validation of potent shRNA sequences against SEMA3B

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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEMA3B Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEMA3B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA3B

Additional cDNA sequence:

AB083186.1 AB209322.1 AF217991.1 AK092182.1 AK293678.1 AK308875.1 BC009113.1 BC013975.2

BC024220.2 BC044602.1 U28369.1

19 DOTS entries:

DT.100784366 DT.97859009 DT.97836288 DT.87017274 DT.87017280 DT.100819096 DT.91789262 DT.91745332

DT.95195655 DT.120882210 DT.91745333 DT.91745334 DT.95195707 DT.120882222 DT.91745341 DT.91990558

DT.95195661 DT.95195689 DT.95195698

24/269 AceView cDNA sequences (see all 269):

AF217991 AB083186 AA480188 BM706729 BF725238 CB049768 BC013975 BC024220

BQ695084 BE019092 R36632 BF002376 BQ940740 BC009113 AI560881 AW009670

AK092182 CR603294 CB153520 NM_004636 BM547638 BQ026623 CB108075 U28369

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for SEMA3B (see all 17) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8a	·	8b	·	8c	·	8d	^	9	^	10a	·	10b	^	11a	·	11b	·	11c	^	12a	·	12b	·	12c	^
SP1:													-				-										-		-		-										-		-
SP2:													-				-										-		-		-										-		-
SP3:													-				-										-		-		-										-
SP4:													-				-										-		-		-
SP5:																											-		-		-										-		-

ExUns:	13a	·	13b	^	14a	·	14b	^	15	^	16a	·	16b	·	16c	·	16d	^	17	^	18	^	19a	·	19b	·	19c	·	19d	·	19e
SP1:					-						-
SP2:					-						-
SP3:					-						-
SP4:					-						-
SP5:					-						-

ECgene alternative splicing isoforms for SEMA3B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SEMA3B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCCGCCCGC

About this image

SEMA3B expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SEMA3B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEMA3B

SOURCE GeneReport for Unigene cluster: Hs.82222

UniProtKB/Swiss-Prot: SEM3B_HUMAN, Q13214

Tissue specificity: Expressed abundantly but differentially in a variety of neural and nonneural tissues

SABiosciences Expression via Pathway-Focused PCR Arrays including SEMA3B:

Lung Cancer in human mouse rat

Neurotoxicity in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEMA3B Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEMA3B

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SEMA3B gene from 3/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Sema3b^{1 , 5}	sema domain, immunoglobulin domain (Ig), short basic more^{1, 5}	83.13(n)¹ 88.65(a)¹	9 (58.31 cM)⁵ 20347¹ NM_001042779.1¹ NP_001036244.1¹ 107597674⁵
chicken (Gallus gallus)	Aves	SEMA3B¹	sema domain, immunoglobulin domain (Ig), short basic more	77.22(n) 78.41(a)	426234 XM_423897.3 XP_423897.3
zebrafish (Danio rerio)	Actinopterygii	si:ch211-106g4.2¹	si:ch211-106g4.2	63.87(n) 65.29(a)	567064 NM_001128346.1 NP_001121818.1

ENSEMBL Gene Tree for SEMA3B (if available)
TreeFam Gene Tree for SEMA3B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141381599^1,2		--	50303157(+)	`ATCCTC/TGAGGA`	2	--	us2k¹		0	--	--	--	--
rs116733481^1,2	F	--	50303198(+)	`TGACCT/CTGCTC`	2	--	us2k¹		1		WA	118
rs114371770^1,2	F	--	50303408(+)	`TAGTCC/TTTTTG`	2	--	us2k¹		1		WA	118
rs147429858^1,2		--	50303416(+)	`TTGGCA/TGGGGG`	2	--	us2k¹		0	--	--	--	--
rs191797794^1,2		--	50303503(+)	`TGGAGC/GAAGGT`	2	--	us2k¹		0	--	--	--	--
rs139715543^1,2		--	50303646(+)	`TGTAAA/GCAGCC`	2	--	us2k¹		0	--	--	--	--
rs145244137^1,2		--	50303714(+)	`AGAGGC/TAGCTA`	2	--	us2k¹		0	--	--	--	--
rs147183345^1,2		--	50303741(+)	`AGGCCA/GCATCC`	2	--	us2k¹		0	--	--	--	--
rs116054729^1,2	F	--	50303996(+)	`ACTTGA/GAATGC`	2	--	us2k¹		1		WA	118
rs139318009^1,2		--	50304008(+)	`CACACG/TGCCCC`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SEMA3B (50304990 - 50314977 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for SEMA3B
5 CNVs: 30176 4335 3429 53228 4336

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SEMA3B for disorders           About GeneDecksing

OMIM gene information: 601281    OMIM disorders: --

17 diseases for SEMA3B:    About MalaCards

phencyclidine abuse clear cell renal cell carcinoma renal cell carcinoma neuronitis

breast cancer ovarian carcinoma periodontitis ovarian cancer

nasopharyngitis carcinoma lung cancer prostate cancer

glioblastoma neuroblastoma prostatitis schizophrenia

adenocarcinoma

1 disease from the University of Copenhagen DISEASES database for SEMA3B:

Phencyclidine abuse

7 Novoseek disease relationships for SEMA3B gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer lung	45.9	8	15831529 (1), 14659031 (1), 18757406 (1), 12561429 (1) (see all 6)
tumors	36.4	56	17452250 (5), 18458115 (5), 12561429 (4), 18922901 (4) (see all 15)
nsclc	33.6	7	12810670 (5)
cancer	13.1	3	18458115 (2)
breast cancer	3.82	11	18922901 (4), 15273288 (3), 15985208 (1)
metastasis	0	2	17010410 (1)
carcinoma	0	3	17010410 (2)

Genetic Association Database (GAD): SEMA3B
Human Genome Epidemiology (HuGE) Navigator: SEMA3B (3 documents)

Export disorders for SEMA3B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SEMA3B gene, integrated from 9 sources (see all 57):
(articles sorted by number of sources associating them with SEMA3B)

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Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns. (PubMed id 8633026)^{1, 2, 3} Sekido Y.... Minna J.D. (1996)
The race associated allele of Semaphorin 3B (SEMA3B) T415I and its role in lung cancer in African-Americans and Latino-Americans. (PubMed id 15831529)^{1, 4, 9} Marsit C.J....Kelsey K.T. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. (PubMed id 11085536)^{1, 2} Lerman M.I. and Minna J.D. (2000)
Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. (PubMed id 7748561)^{1, 3} Puschel A.W....Betz H. (1995)
Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF165 antagonizes this effect. (PubMed id 15273288)^{1, 9} Castro-Rivera E....Minna J.D. (2004)
Semaphorin-3B is an angiogenesis inhibitor that is inactivated by furin-like pro-protein convertases. (PubMed id 18757406)^{1, 9} Varshavsky A....Neufeld G. (2008)
Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells. (PubMed id 18922901)^{1, 9} Castro-Rivera E....Minna J.D. (2008)
High-resolution analysis of 3p deletion in neuroblastoma and differential methylation of the SEMA3B tumor suppressor gene. (PubMed id 17452250)^{1, 9} Nair P.N....Stallings R.L. (2007)
Allelic loss on chromosome 3p21.3 and promoter hypermethylation of semaphorin 3B in non-small cell lung cancer. (PubMed id 12810670)^{1, 9} Kuroki T....Croce C.M. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7869	HGNC: 10724	AceView: SEMA3B	Ensembl:ENSG00000012171	euGenes: HUgn7869
ECgene: SEMA3B	Kegg: 7869	H-InvDB: SEMA3B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SEMA3B	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SEMA3B	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SEMA3B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SEMA3B gene:
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GeneCards and IP:
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