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Aliases for SEMA3B Gene

Aliases for SEMA3B Gene

  • Semaphorin 3B 2 3
  • Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3B 2 3 5
  • Semaphorin-V 3 4
  • Sema A(V) 3 4
  • SEMAA 3 4
  • SEMA5 3 4
  • Semaphorin A 3
  • LuCa-1 3
  • Sema V 4
  • SemaV 3
  • SemA 3

External Ids for SEMA3B Gene

Previous HGNC Symbols for SEMA3B Gene

  • SEMAA

Previous GeneCards Identifiers for SEMA3B Gene

  • GC03M049672
  • GC03M049841
  • GC03P050159
  • GC03P050265
  • GC03P050281
  • GC03P050304

Summaries for SEMA3B Gene

Entrez Gene Summary for SEMA3B Gene

  • The protein encoded by this gene belongs to the class-3 semaphorin/collapsin family, whose members function in growth cone guidance during neuronal development. This family member inhibits axonal extension and has been shown to act as a tumor suppressor by inducing apoptosis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for SEMA3B Gene

SEMA3B (Semaphorin 3B) is a Protein Coding gene. Diseases associated with SEMA3B include phencyclidine abuse and lung cancer. Among its related pathways are Axon guidance and Neuroscience. GO annotations related to this gene include receptor activity. An important paralog of this gene is SEMA3F.

UniProtKB/Swiss-Prot for SEMA3B Gene

  • Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.

Gene Wiki entry for SEMA3B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMA3B Gene

Genomics for SEMA3B Gene

Regulatory Elements for SEMA3B Gene

Enhancers for SEMA3B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SEMA3B on UCSC Golden Path with GeneCards custom track

Promoters for SEMA3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SEMA3B on UCSC Golden Path with GeneCards custom track

Genomic Location for SEMA3B Gene

Chromosome:
3
Start:
50,267,558 bp from pter
End:
50,277,546 bp from pter
Size:
9,989 bases
Orientation:
Plus strand

Genomic View for SEMA3B Gene

Genes around SEMA3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEMA3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEMA3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMA3B Gene

Proteins for SEMA3B Gene

  • Protein details for SEMA3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13214-SEM3B_HUMAN
    Recommended name:
    Semaphorin-3B
    Protein Accession:
    Q13214
    Secondary Accessions:
    • Q6GU46
    • Q8TB71
    • Q8TDV7
    • Q93018
    • Q96GX0

    Protein attributes for SEMA3B Gene

    Size:
    749 amino acids
    Molecular mass:
    83122 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC02731.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SEMA3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEMA3B Gene

Proteomics data for SEMA3B Gene at MOPED

Post-translational modifications for SEMA3B Gene

  • Glycosylation at Asn 82, Asn 124, Asn 427, and Thr 611
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for SEMA3B (Semaphorin 3B)
  • Cell Signaling Technology (CST) Antibodies for SEMA3B (SEMA3B)

No data available for DME Specific Peptides for SEMA3B Gene

Domains & Families for SEMA3B Gene

Suggested Antigen Peptide Sequences for SEMA3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13214

UniProtKB/Swiss-Prot:

SEM3B_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Belongs to the semaphorin family.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 PSI domain.
  • Contains 1 Sema domain.
Family:
  • Belongs to the semaphorin family.
genes like me logo Genes that share domains with SEMA3B: view

Function for SEMA3B Gene

Molecular function for SEMA3B Gene

GENATLAS Biochemistry:
semaphorin 3B,secreted,expressed in neuronal and non neuronal tissues,repellent of the nerve growth cone guidance
UniProtKB/Swiss-Prot Function:
Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.

Phenotypes for SEMA3B Gene

genes like me logo Genes that share phenotypes with SEMA3B: view

Animal Models for SEMA3B Gene

MGI Knock Outs for SEMA3B:

Animal Model Products

  • Taconic Biosciences Mouse Models for SEMA3B

miRNA for SEMA3B Gene

miRTarBase miRNAs that target SEMA3B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SEMA3B Gene

Localization for SEMA3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMA3B Gene

Secreted. Endoplasmic reticulum. Note=Accumulates in the endoplasmic reticulum.

Gene Ontology (GO) - Cellular Components for SEMA3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with SEMA3B: view

No data available for Subcellular locations from COMPARTMENTS for SEMA3B Gene

Pathways & Interactions for SEMA3B Gene

SuperPathways for SEMA3B Gene

Superpath Contained pathways
1 Axon guidance
2 Neuroscience
genes like me logo Genes that share pathways with SEMA3B: view

Pathways by source for SEMA3B Gene

1 Cell Signaling Technology pathway for SEMA3B Gene
1 KEGG pathway for SEMA3B Gene

Interacting Proteins for SEMA3B Gene

Selected Interacting proteins: Q13214-SEM3B_HUMAN for SEMA3B Gene via I2D

Gene Ontology (GO) - Biological Process for SEMA3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001755 neural crest cell migration IBA --
GO:0007411 axon guidance TAS 8633026
genes like me logo Genes that share ontologies with SEMA3B: view

No data available for SIGNOR curated interactions for SEMA3B Gene

Drugs & Compounds for SEMA3B Gene

(1) Drugs for SEMA3B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for SEMA3B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SEMA3B: view

Transcripts for SEMA3B Gene

Unigene Clusters for SEMA3B Gene

Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEMA3B Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - -
SP7: - - - - - - -
SP8: - - - -
SP9: - - - - -
SP10:
SP11: - - - - - -
SP12:
SP13:
SP14: - - - - - -
SP15:
SP16: - - - -
SP17:

ExUns: 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c · 16d ^ 17 ^ 18 ^ 19a · 19b · 19c · 19d · 19e
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6: - -
SP7: - - - - -
SP8:
SP9:
SP10: -
SP11: - -
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for SEMA3B Gene

GeneLoc Exon Structure for
SEMA3B
ECgene alternative splicing isoforms for
SEMA3B

Expression for SEMA3B Gene

mRNA expression in normal human tissues for SEMA3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEMA3B Gene

This gene is overexpressed in Nerve - Tibial (x6.0) and Adrenal Gland (x4.5).

Protein differential expression in normal tissues from HIPED for SEMA3B Gene

This gene is overexpressed in Testis (68.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SEMA3B Gene



SOURCE GeneReport for Unigene cluster for SEMA3B Gene Hs.82222

mRNA Expression by UniProt/SwissProt for SEMA3B Gene

Q13214-SEM3B_HUMAN
Tissue specificity: Expressed abundantly but differentially in a variety of neural and nonneural tissues.
genes like me logo Genes that share expression patterns with SEMA3B: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for SEMA3B Gene

Orthologs for SEMA3B Gene

This gene was present in the common ancestor of chordates.

Orthologs for SEMA3B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SEMA3B 35
  • 87.3 (n)
  • 90.24 (a)
dog
(Canis familiaris)
Mammalia SEMA3B 35
  • 87.12 (n)
  • 90.24 (a)
mouse
(Mus musculus)
Mammalia Sema3b 35
  • 83.13 (n)
  • 88.65 (a)
Sema3b 16
chimpanzee
(Pan troglodytes)
Mammalia SEMA3B 35
  • 97.85 (n)
  • 96.63 (a)
rat
(Rattus norvegicus)
Mammalia Sema3b 35
  • 83.49 (n)
  • 89.19 (a)
chicken
(Gallus gallus)
Aves SEMA3B 35
  • 77.22 (n)
  • 78.41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sema3b 35
  • 63.12 (n)
  • 66.25 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-106g4.2 35
  • 63.95 (n)
  • 65.19 (a)
Species with no ortholog for SEMA3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SEMA3B Gene

ENSEMBL:
Gene Tree for SEMA3B (if available)
TreeFam:
Gene Tree for SEMA3B (if available)

Paralogs for SEMA3B Gene

genes like me logo Genes that share paralogs with SEMA3B: view

Variants for SEMA3B Gene

Sequence variations from dbSNP and Humsavar for SEMA3B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_014221 A non-small cell lung cancer cell line
VAR_014222 A non-small cell lung cancer cell line
rs2071203 A non-small cell lung cancer cell line 50,274,469(-) CCCCA(A/G)TGGGC nc-transcript-variant, reference, missense
rs2269430 -- 50,269,619(+) ACCCC(C/T)AACAA intron-variant
rs2269431 -- 50,273,890(+) CTCAC(C/T)TCGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEMA3B Gene

Variant ID Type Subtype PubMed ID
nsv523662 CNV Loss 19592680
nsv876769 CNV Loss 21882294
nsv470561 CNV Loss 18288195
nsv876770 CNV Loss 21882294
nsv523560 CNV Loss 19592680
dgv602n27 CNV Loss 19166990
dgv1456e1 CNV Complex 17122850
nsv834692 CNV Loss 17160897
nsv460531 CNV Loss 19166990
dgv5131n71 CNV Loss 21882294
dgv5132n71 CNV Loss 21882294
nsv834693 CNV Loss 17160897

Relevant External Links for SEMA3B Gene

HapMap Linkage Disequilibrium report
SEMA3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SEMA3B Gene

Disorders for SEMA3B Gene

MalaCards: The human disease database

(2) MalaCards diseases for SEMA3B Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
phencyclidine abuse
  • pcp abuse
lung cancer
  • lung cancer, protection against
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SEMA3B

Genetic Association Database (GAD)
SEMA3B
Human Genome Epidemiology (HuGE) Navigator
SEMA3B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEMA3B
genes like me logo Genes that share disorders with SEMA3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SEMA3B Gene

Publications for SEMA3B Gene

  1. Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns. (PMID: 8633026) Sekido Y. … Minna J.D. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 67
  2. Hormonal regulation and distinct functions of semaphorin-3B and semaphorin-3F in ovarian cancer. (PMID: 20124444) Joseph D. … Syed V. (Mol. Cancer Ther. 2010) 3 23
  3. Semaphorin 3B and 3F single nucleotide polymorphisms are associated with prostate cancer risk and poor prognosis. (PMID: 19683737) Beuten J. … Naylor S.L. (J. Urol. 2009) 3 23
  4. The tumor suppressor semaphorin 3B triggers a prometastatic program mediated by interleukin 8 and the tumor microenvironment. (PMID: 18458115) Rolny C. … Tamagnone L. (J. Exp. Med. 2008) 3 23
  5. Semaphorin-3B is an angiogenesis inhibitor that is inactivated by furin-like pro-protein convertases. (PMID: 18757406) Varshavsky A. … Neufeld G. (Cancer Res. 2008) 3 23

Products for SEMA3B Gene

Sources for SEMA3B Gene

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