Aliases for SEMA3A Gene
External Ids for SEMA3A Gene
Previous HGNC Symbols for SEMA3A Gene
Previous GeneCards Identifiers for SEMA3A Gene
This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq, Jul 2008]
GeneCards Summary for SEMA3A Gene
SEMA3A (Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3A) is a Protein Coding gene. Diseases associated with SEMA3A include sema3a-related isolated gonadotropin-releasing hormone deficiency and hypogonadotropic hypogonadism 16 with or without anosmia. Among its related pathways are Developmental Biology and NF-KappaB Family Pathway. GO annotations related to this gene include receptor activity and chemorepellent activity. An important paralog of this gene is SEMA4G.
UniProtKB/Swiss-Prot for SEMA3A Gene
Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1.