Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SEMA3A Gene

protein-coding   GIFtS: 65
GCID: GC07M083587

Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain,...


(Previous symbol: SEMAD)
  See SEMA3A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted,
(Semaphorin) 3A1 2
     SEMAIII2
SEMAD1 2 3 5     SEMAL2
Sema III1 3     SemD2
Semaphorin III2 3     coll-12
COLL12 5     Collapsin 12
HH162 5     Semaphorin D2
Hsema-I2     Semaphorin L2
Hsema-III2     semaphorin-3A2
SEMA12     

External Ids:    HGNC: 107231   Entrez Gene: 103712   Ensembl: ENSG000000752137   OMIM: 6039615   UniProtKB: Q145633   

Export aliases for SEMA3A gene to outside databases

Previous GC identifers: GC07M082125 GC07M083188 GC07M083202 GC07M083235 GC07M083428 GC07M078196


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SEMA3A Gene:
This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like)
domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent,
inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both
cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is
associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this
protein is associated with the progression of Alzheimer's disease. (provided by RefSeq, Jul 2008)

GeneCards Summary for SEMA3A Gene:
SEMA3A (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A) is a protein-coding gene. Diseases associated with SEMA3A include hypogonadotropic hypogonadism 16 with or without anosmia, and wallerian degeneration. GO annotations related to this gene include chemorepellent activity and receptor activity. An important paralog of this gene is SEMA3C.

UniProtKB/Swiss-Prot: SEM3A_HUMAN, Q14563
Function: Involved in the development of the olfactory system and in neuronal control of puberty. Induces the
collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a
motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1

Gene Wiki entry for SEMA3A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SEMA3A gene promoter:
         STAT1   AP-1   Brachyury   ATF-2   Ik-3   FOXL1   Arnt   S8   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEMA3A promoter sequence
   Search Chromatin IP Primers for SEMA3A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEMA3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p12.1   Ensembl cytogenetic band:  7q21.11   HGNC cytogenetic band: 7p12.1

SEMA3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEMA3A gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M083587:  view genomic region     (about GC identifiers)

Start:
83,585,093 bp from pter      End:
84,122,040 bp from pter
Size:
536,948 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 82,919,781-83,156,009     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SEM3A_HUMAN, Q14563 (See protein sequence)
Recommended Name: Semaphorin-3A precursor  
Size: 771 amino acids; 88889 Da
Subunit: Interacts with PLXND1 (By similarity)

Explore the universe of human proteins at neXtProt for SEMA3A: NX_Q14563

Explore proteomics data for SEMA3A at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn53, Asn125, Asn590
  • Modification sites at PhosphoSitePlus

  • See SEMA3A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006071.1  
    ENSEMBL proteins: 
     ENSP00000265362   ENSP00000415260   ENSP00000391900   ENSP00000402093   ENSP00000404800  
    Reactome Protein details: Q14563

    SEMA3A Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant SEMA3A Protein
    R&D Systems Recombinant & Natural Proteins for SEMA3A (Semaphorin 3A)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SEMA3A
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SEMA3A
    GenScript Custom Purified and Recombinant Proteins Services for SEMA3A
    Novus Biologicals SEMA3A Protein
    Novus Biologicals SEMA3A Lysate
    Sino Biological Recombinant Protein for SEMA3A
    Sino Biological Cell Lysate for SEMA3A
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEMA3A

     
    Search eBioscience for Proteins for SEMA3A 

     
    antibodies-online proteins for SEMA3A (16 products) 

     
    antibodies-online peptides for SEMA3A

    SEMA3A Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SEMA3A
    R&D Systems Antibodies for SEMA3A (Semaphorin 3A)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SEMA3A
    Novus Biologicals SEMA3A Antibodies
    Abcam antibodies for SEMA3A
    Cloud-Clone Corp. Antibodies for SEMA3A
    ThermoFisher Antibodies for SEMA3A
    LSBio Antibodies in human, mouse, rat for SEMA3A
    antibodies-online antibodies for SEMA3A (36 products) 

    SEMA3A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SEMA3A
    R&D Systems Proteome Profiler Antibody Arrays for SEMA3A (Semaphorin 3A)
    GenScript Custom Assay Services for SEMA3A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SEMA3A
    Cloud-Clone Corp. CLIAs for SEMA3A
    Search eBioscience for ELISAs for SEMA3A 
    antibodies-online kits for SEMA3A (19 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    SEMA: Semaphorins

    Selected InterPro protein domains (see all 7):
     IPR013783 Ig-like_fold
     IPR027231 Semaphorin
     IPR001627 Semap_dom
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q14563

    ProtoNet protein and cluster: Q14563

    2 Blocks protein domains:
    IPB001627 Semaphorin/CD100 antigen
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: SEM3A_HUMAN, Q14563
    Domain: Strong binding to neuropilin is mediated by the carboxy third of the protein
    Similarity: Belongs to the semaphorin family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 PSI domain
    Similarity: Contains 1 Sema domain


    Find genes that share domains with SEMA3A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEM3A_HUMAN, Q14563
    Function: Involved in the development of the olfactory system and in neuronal control of puberty. Induces the
    collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a
    motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1

         Genatlas biochemistry entry for SEMA3A:
    semaphorin 3A,secreted,repellent of the nerve growth cone guidance

         Summary: 
    During embryonic development, SEMA3A as signaling molecule is secreted from the following cells:
                
    Eye: Lens Vesicle Cells (Lens Vesicle)

    It affects the following cells:
    Brain: Fetal Dopaminergic Neurons (Ventral Tegmental Area), Fetal Dopaminergic Neurons (Substantia Nigra pars Compacta)       to see all 2 cells
    Eye: Periocular Mesenchymal Cells (Periocular Mesenchyme)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----
    GO:0030215semaphorin receptor binding IEA--
    GO:0045499chemorepellent activity TAS19909241
         
    Find genes that share ontologies with SEMA3A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SEMA3A:
     Decreased focal adhesion (FA)  

         12 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Sema3a):
     behavior/neurological  cardiovascular system  cellular  growth/size/body  hematopoietic system 
     immune system  mortality/aging  nervous system  no phenotypic analysis  renal/urinary system 
     respiratory system  skeleton 

    Find genes that share phenotypes with SEMA3A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SEMA3A: Sema3atm1.1Tyag Sema3atm1Mcf

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEMA3A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SEMA3A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEMA3A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEMA3A

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SEMA3A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEMA3A (see all 85):
    hsa-miR-517a hsa-miR-4272 hsa-miR-15a hsa-miR-199a-3p hsa-miR-411 hsa-miR-605 hsa-miR-1260b hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidSEMA3A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SEMA3A
    Predesigned siRNA for gene silencing in human, mouse, rat SEMA3A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SEMA3A

    Clone
    Products:
         
    OriGene clones in human, mouse for SEMA3A (see all 7)
    OriGene ORF clones in mouse, rat for SEMA3A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEMA3A (NM_006080)
    Sino Biological Human cDNA Clone for SEMA3A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA3A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA3A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SEMA3A
    Browse ESI BIO Cell Lines and PureStem Progenitors for SEMA3A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SEM3A_HUMAN, Q14563: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    cytoskeleton2
    cytosol1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0016020membrane IEA--
    GO:0030424axon IEA--
    GO:0030425dendrite IEA--

    Find genes that share ontologies with SEMA3A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SEMA3A About   (see all 18)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51


    Find genes that share SuperPaths with SEMA3A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SEMA3A (see all 56)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for SEMA3A
        Neurophysiological process Receptor-mediated axon growth repulsion


    3 Reactome Pathways for SEMA3A
        CRMPs in Sema3A signaling
    Sema3A PAK dependent Axon repulsion
    SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion


    1 Kegg Pathway  (Kegg details for SEMA3A):
        Axon guidance

        Pathway & Disease-focused RT2 Profiler PCR Array including SEMA3A: 
              Embryonic Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SEMA3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SEMA3A (Q145633 ENSP000002653624) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPR1P160663, ENSP000003576694I2D: score=1 STRING: ENSP00000357669
    NRP1O147863, ENSP000002653714I2D: score=1 STRING: ENSP00000265371
    SEMA3BQ132143I2D: score=1 
    CDK5ENSP000002975184STRING: ENSP00000297518
    CDK5R1ENSP000003184864STRING: ENSP00000318486
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration ISS--
    GO:0002027regulation of heart rate IEA--
    GO:0006915apoptotic process IEA--
    GO:0007275multicellular organismal development ----
    GO:0007411axon guidance TAS19909241

    Find genes that share ontologies with SEMA3A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEMA3A (SEM3A)

    5 Novoseek inferred chemical compound relationships for SEMA3A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 49.2 38 14656993 (4), 12617854 (2), 14500350 (2), 14516677 (2) (see all 13)
    guanylate 3.34 2 10766232 (2)
    calcium 0 3 18549782 (1), 19650914 (1), 15831706 (1)
    tyrosine 0 7 20159040 (2), 18831963 (1), 11331362 (1), 12611639 (1)
    serine 0 1 10588393 (1)



    Find genes that share compounds with SEMA3A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SEMA3A gene: 
    NM_006080.2  

    Unigene Cluster for SEMA3A:

    Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
    Hs.252451  [show with all ESTs]
    Unigene Representative Sequence: NM_006080
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265362(uc003uhz.3) ENST00000436949 ENST00000420047 ENST00000448879
    ENST00000424555 ENST00000471474 ENST00000490883
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SEMA3A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEMA3A (see all 85):
    hsa-miR-517a hsa-miR-4272 hsa-miR-15a hsa-miR-199a-3p hsa-miR-411 hsa-miR-605 hsa-miR-1260b hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidSEMA3A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SEMA3A
    Predesigned siRNA for gene silencing in human, mouse, rat SEMA3A
    Clone
    Products:
         
    OriGene clones in human, mouse for SEMA3A (see all 7)
    OriGene ORF clones in mouse, rat for SEMA3A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEMA3A (NM_006080)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEMA3A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA3A
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SEMA3A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEMA3A
      QuantiTect SYBR Green Assays in human, mouse, rat SEMA3A
      QuantiFast Probe-based Assays in human, mouse, rat SEMA3A

    Additional mRNA sequence: 

    AK289954.1 BC111416.1 L26081.1 

    3 DOTS entries:

    DT.205342  DT.75107544  DT.100831605 

    Selected AceView cDNA sequences (see all 64):

    BM670627 AA861394 BI870437 BQ447821 BQ007348 BM711125 BQ018643 AA450244 
    AI240274 BU687513 BX283116 BU729715 AA451750 AW207285 BM723807 CD216784 
    BM090784 BE905111 L26081 N51438 AI734867 AI671991 AW079904 BM729169 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SEMA3A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SEMA3A Expression
    About this image


    SEMA3A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 4 entries
             Odontoblasts Dentin
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Lens
             Limbal epithelial stem cells (family)
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Midbrain tegmentum
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Ureteric Bud Cells Ureteric Bud
             Metanephros
     
     Epithelial Cells
             Dental Placode Cells Dental Placode
    SEMA3A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEMA3A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.252451
        Pathway & Disease-focused RT2 Profiler PCR Array including SEMA3A: 
              Embryonic Stem Cells in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SEMA3A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEMA3A
    QuantiTect SYBR Green Assays in human, mouse, rat SEMA3A
    QuantiFast Probe-based Assays in human, mouse, rat SEMA3A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SEMA3A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sema3a1 , 5 sema domain, immunoglobulin domain (Ig), short basic more1, 5 88.63(n)1
    95.59(a)1
      5 (4.31 cM)5
    203461  NM_001243073.11  NP_001230002.11 
     133967845 
    chicken
    (Gallus gallus)
    Aves SEMA3A1 sema domain, immunoglobulin domain (Ig), short basic more 81.88(n)
    88.59(a)
      395825  NM_204977.1  NP_990308.2 
    lizard
    (Anolis carolinensis)
    Reptilia SEMA3A6
    sema domain, immunoglobulin domain (Ig), short bas...
    88(a)
    1 ↔ 1
    5(87899979-88133573)
    African clawed frog
    (Xenopus laevis)
    Amphibia sema3a-A2 sema domain, immunoglobulin domain (Ig), short basic more 82.73(n)    AY030051.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sema3ab2 semaphorin 3ab 75.62(n)   30267  AF083382.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sema-1a3
    Sema-2a1
    axon guidance3
    Sema-2a1
    34(a)
    (best of 4)3
    46.57(n)1
    38.96(a)1
      368461  NM_058159.41  NP_477507.11 


    ENSEMBL Gene Tree for SEMA3A (if available)
    TreeFam Gene Tree for SEMA3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SEMA3A gene
    SEMA3C2  SEMA4F2  SEMA3E2  SEMA4B2  SEMA4C2  SEMA3F2  SEMA4A2  SEMA4D2  
    SEMA4G2  SEMA3G2  SEMA3D2  
    Selected SIMAP similar genes for SEMA3A using alignment to 5 protein entries:     SEM3A_HUMAN (see all proteins) (see all similar genes):
    SEMA3D    SEMA3B    SEMA3E    SEMA3F    SEMA3C    SEMA3G
    SEMA5B    SEMA4D variant protein    SEMA4D    SEMA4B    DKFZp686A04130    SEMA6A
    SEMA6C    SEMA6D    SEMA4G    SEMA4F    SEMA4C    SEMA7A

    Find genes that share paralogs with SEMA3A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SEMA3A (see all 5178)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3182407531,2,,4
    CHypogonadotropic hypogonadism 16 with or without anosmia (HH16)4 untested186898202(-) ACAACA/GTCGGC 2 H R mis10--------
    rs3182407521,2,,4
    CHypogonadotropic hypogonadism 16 with or without anosmia (HH16)4 untested186898211(-) GGACCA/GAAAAC 2 Q R mis10--------
    rs3182407511,2,,4
    CHypogonadotropic hypogonadism 16 with or without anosmia (HH16)4 untested186898338(-) CTAAGA/GCCAAA 2 T A mis10--------
    rs1474361811,2,,4
    C,FHypogonadotropic hypogonadism 16 with or without anosmia (HH16)4 untested186942230(+) TACGAC/TAATTT 2 I V mis12Minor allele frequency- T:0.01NA EU 5871
    rs360268601,2,,4
    C,FHypogonadotropic hypogonadism 16 with or without anosmia (HH16)4 untested186942335(-) ATGTTA/GTAACC 2 I V mis12Minor allele frequency- G:0.00NA 4626
    rs1392951391,2,,4
    C,FHypogonadotropic hypogonadism 16 with or without anosmia (HH16)4 untested186997378(+) AAATAT/CTGTCC 2 /N /S mis12Minor allele frequency- C:0.01NA EU 5667
    rs1999796281,2,,4
    CHypogonadotropic hypogonadism 16 with or without anosmia (HH16)4 untested187071139(+) ACTCCG/ATTCCT 2 /R /W mis11Minor allele frequency- A:0.00EU 1323
    VAR_0362834
    A breast cancer sample4--see VAR_0362832 A T mis40--------
    rs1124771911,2
    C--78205068(+) TTTTCC/TTTTTT 1 -- int10--------
    rs353618921,2
    F--78215395(+) AGAGAGA/-TGCAT 1 -- int13Minor allele frequency- -:0.30CSA 10

    HapMap Linkage Disequilibrium report for SEMA3A (83585093 - 83835093 bp, first 250kb of SEMA3A)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SEMA3A (see all 32):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv993949CNV Deletion20482838
    esv2734762CNV Deletion23290073
    esv3024CNV Deletion18987735
    esv2359570CNV Deletion18987734
    esv2584536CNV Deletion19546169
    esv1617967CNV Deletion17803354
    esv2657057CNV Deletion23128226
    esv2086328CNV Deletion18987734
    esv1251085CNV Deletion17803354
    esv2734760CNV Deletion23290073

    Human Gene Mutation Database (HGMD): SEMA3A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEMA3A
    DNA2.0 Custom Variant and Variant Library Synthesis for SEMA3A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603961   
    OMIM disorders: 614897  
    UniProtKB/Swiss-Prot: SEM3A_HUMAN, Q14563
  • Hypogonadotropic hypogonadism 16 with or without anosmia (HH16) [MIM:614897]: A disorder characterized by
    absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating
    gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it
    is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss.
    Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is
    due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of
    gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic
    hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been
    termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). Note=The disease may be caused by mutations
    affecting distinct genetic loci, including the gene represented in this entry

  • 5 diseases for SEMA3A:    
    About MalaCards
    hypogonadotropic hypogonadism 16 with or without anosmia    wallerian degeneration    spondyloepimetaphyseal dysplasia    hypogonadotropic hypogonadism 8 with or without anosmia
    schizophrenia

    4 diseases from the University of Copenhagen DISEASES database for SEMA3A:
    Spondyloepimetaphyseal dysplasia     Aphasia     Sponastrime dysplasia     Frontotemporal dementia

    Find genes that share disorders with SEMA3A           About GenesLikeMe

    5 Novoseek inferred disease relationships for SEMA3A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    scar 6.27 2 9932407 (1), 18160633 (1)
    neurodegenerative diseases 0 1 15485501 (1)
    metastasis 0 3 17631638 (1)
    tumors 0 15 16380453 (4), 17631638 (3), 14656993 (1), 17569671 (1)
    cancer 0 6 19817889 (3), 14500350 (1), 17390026 (1), 19465334 (1)

    Genetic Association Database (GAD): SEMA3A
    Human Genome Epidemiology (HuGE) Navigator: SEMA3A (4 documents)

    Export disorders for SEMA3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SEMA3A gene, integrated from 10 sources (see all 203):
    (articles sorted by number of sources associating them with SEMA3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules. (PubMed id 8269517)1, 2, 3, 9 Kolodkin A.L.... Goodman C.S. (Cell 1993)
    2. SEMA3A deletion in a family with Kallmann syndrome validates the role of semaphorin 3A in human puberty and olfactory system development. (PubMed id 22416012)1, 2 Young J.... Guiochon-Mantel A. (Hum. Reprod. 2012)
    3. SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome. (PubMed id 22927827)1, 2 Hanchate N.K.... Dode C. (PLoS Genet. 2012)
    4. Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP. (PubMed id 22210626)1, 4 Mead S....Collinge J. (Hum. Mol. Genet. 2012)
    5. Genome-wide association study of the child behavior checklist dysregulation profile. (PubMed id 21784300)1, 4 Mick E....Faraone S.V. (J Am Acad Child Adolesc Psychiatry 2011)
    6. GWAS findings for human iris patterns: associations with variants in genes that influence normal neuronal pattern development. (PubMed id 21835309)1, 4 Larsson M....Medland S.E. (Am. J. Hum. Genet. 2011)
    7. Candidate gene analysis of semaphorins in patients with Alzheimer's disease. (PubMed id 19957197)1, 4 Villa C....Galimberti D. (Neurol. Sci. 2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    10. Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. (PubMed id 7748561)1, 3 PA1schel A.W....Betz H. (Neuron 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10371 HGNC: 10723 AceView: SEMA3A Ensembl:ENSG00000075213 euGenes: HUgn10371
    ECgene: SEMA3A Kegg: 10371 H-InvDB: SEMA3A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SEMA3A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SEMA3A gene:
    Search GeneIP for patents involving SEMA3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     EMD Millipore Purified and/or Recombinant SEMA3A Protein
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SEMA3A
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for SEMA3A (Semaphorin 3A)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for SEMA3A (Semaphorin 3A)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for SEMA3A (Semaphorin 3A)  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SEMA3A  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SEMA3A  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SEMA3A  
     OriGene qSTAR qPCR primer pairs in human, mouse for SEMA3A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SEMA3A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SEMA3A   OriGene Custom Protein Services for SEMA3A  

     
     
     Block miRNA regulation of human, mouse, rat SEMA3A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SEMA3A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEMA3A Predesigned siRNA for gene silencing in human, mouse, rat SEMA3A
     QuantiFast Probe-based Assays in human, mouse, rat SEMA3A QuantiTect SYBR Green Assays in human, mouse, rat SEMA3A
     PCR Arrays including human, mouse, rat SEMA3A Search Chromatin IP Primers for SEMA3A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEMA3A  GeneGlobe Interaction Network for SEMA3A
     Regulatory tfbs in SEMA3A promoter
     GenScript Custom Purified and Recombinant Proteins Services for SEMA3A GenScript cDNA clones with any tag delivered in your preferred vector for SEMA3A
     GenScript Custom Assay Services for SEMA3A GenScript Custom overexpressing Cell Line Services for SEMA3A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SEMA3A (SEM3A)
     Proteins for SEMA3A
     Cell Lysates for SEMA3A
     cDNA Clones for SEMA3A
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SEMA3A antibodies
     SEMA3A proteins
     SEMA3A lysates
     Antibodies for SEMA3A
     See all of Abcam's Antibodies, Kits and Proteins for SEMA3A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SEMA3A
     Antibodies for SEMA3A
     ELISAs for SEMA3A
     CLIAs for SEMA3A



     Browse ESI BIO Cell Lines and PureStem Progenitors for SEMA3A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEMA3A
     SwitchGear 3'UTR luciferase reporter plasmids for SEMA3A
     SwitchGear Promoter luciferase reporter plasmids for SEMA3A
     ThermoFisher Antibodies for SEMA3A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEMA3A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEMA3A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SEMA3A
     LSBio Antibodies in human, mouse, rat for SEMA3A
     Browse compounds at ApexBio
     Search Addgene for plasmids for SEMA3A
      Search eBioscience for proteins for SEMA3A
      Search eBioscience for elisas for SEMA3A
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for SEMA3A (36 products)
     antibodies-online kits for SEMA3A (19 products)
     antibodies-online peptides for SEMA3A
     antibodies-online proteins for SEMA3A (16 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SEMA3A gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4