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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SELV Gene

protein-coding   GIFtS: 39
GCID: GC19P040005

Selenoprotein V


  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Selenoprotein V2
SelV3

External Ids:    Entrez Gene: 3483032   Ensembl: ENSG000001868387   OMIM: 6079195   UniProtKB: P597973   

Export aliases for SELV gene to outside databases

Previous GC identifers: GC19P044681 GC19P044697


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SELV Gene:
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The
selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of
selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for
the recognition of UGA as a Sec codon rather than as a stop signal. (provided by RefSeq, Jul 2008)

GeneCards Summary for SELV Gene: 
SELV is a protein-coding gene. Diseases associated with SELV include staphyloenterotoxemia, and chronic lymphocytic leukemia. GO annotations related to this gene include selenium binding. An important paralog of this gene is SEPW1.

UniProtKB/Swiss-Prot: SELV_HUMAN, P59797
Function: May be involved in a redox-related process (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SELV gene promoter:
         E2F-4   E2F-3a   E2F-5   Pax-5   E2F-2   c-Ets-1   CREB   E2F   E2F-1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSELV promoter sequence
   Search SABiosciences Chromatin IP Primers for SELV

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SELV


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   

SELV Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SELV gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P040005:  view genomic region     (about GC identifiers)

Start:
40,005,753 bp from pter      End:
40,011,326 bp from pter
Size:
5,574 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SELV_HUMAN, P59797 (See protein sequence)
Recommended Name: Selenoprotein V  
Size: 346 amino acids; 36800 Da
Secondary accessions: Q17RG5

Explore the universe of human proteins at neXtProt for SELV: NX_P59797

Explore proteomics data for SELV at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P59797

  • SELV Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SELV Protein Expression
    REFSEQ proteins: NP_874363.1  
    ENSEMBL proteins: 
     ENSP00000333956   ENSP00000470671   ENSP00000412508  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR011893 Selenoprotein_Rdx-typ
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry P59797

    ProtoNet protein and cluster: P59797

    UniProtKB/Swiss-Prot: SELV_HUMAN, P59797
    Similarity: Belongs to the SelWTH family


    SELV for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SELV_HUMAN, P59797
    Function: May be involved in a redox-related process (Potential)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008430selenium binding IEA--
         
    SELV for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SELV:
     Decreased viability with pacli  Increased gamma-H2AX phosphory 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidSELV 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SELV About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Selenium Metabolism and Selenoproteins
    Selenium Metabolism and Selenoproteins
    2Selenium Pathway
    Selenium Pathway


    2 BioSystems Pathways for SELV
        Selenium Metabolism and Selenoproteins
    Selenium Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SELV

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045454cell redox homeostasis IEA--

    SELV for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SELV

    Search CenterWatch for drugs/clinical trials and news about SELV

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SELV gene: 
    NM_182704.1  

    Unigene Cluster for SELV:

    Selenoprotein V
    Hs.319284  [show with all ESTs]
    Unigene Representative Sequence: AY324825
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335426(uc021uum.1) ENST00000597876 ENST00000600586 ENST00000423711

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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate SELV (see all 9):
    hsa-miR-492 hsa-miR-196a* hsa-miR-3157-5p hsa-miR-766 hsa-miR-4267 hsa-miR-129-3p hsa-miR-4323 hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidSELV 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SELV
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SELV
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SELV

    Additional mRNA sequence: 

    AY324825.1 BC117331.1 

    2 DOTS entries:

    DT.101977793  DT.91813866 

    4 AceView cDNA sequences:

    AY324825 NM_182704 BM563444 BF056261 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SELV expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTGGTTCC
    SELV Expression
    About this image


    See SELV Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.319284

    UniProtKB/Swiss-Prot: SELV_HUMAN, P59797
    Tissue specificity: Testis specific

        SABiosciences Custom PCR Arrays for SELV
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELV

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SELV gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia BC0894911 , 5 cDNA sequence BC0894911, 5 63.66(n)1
    51.61(a)1
      7 (16.67 cM)5
    2806211  NM_175033.31  NP_778198.21 
     282846525 
    zebrafish
    (Danio rerio)
    Actinopterygii sepw16
    selenoprotein W, 1
    47(a)
    1 → many
    5(65060414-65066854)


    ENSEMBL Gene Tree for SELV (if available)
    TreeFam Gene Tree for SELV (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SELV gene
    SEPW12  
    1 SIMAP similar gene for SELV using alignment to 3 protein entries:     SELV_HUMAN (see all proteins):
    SEPW1

    SELV for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/206 SNPs in SELV are shown (see all 206)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs589497441,2
    C,F--40003819(+) CACAAT/ACACAG 1 -- us2k12Minor allele frequency- A:0.15WA 120
    rs1443014571,2
    C--40003853(+) CATCCA/CGGCCA 1 -- us2k10--------
    rs1511798221,2
    C--40003928(+) GCAGTA/GGTGTG 1 -- us2k10--------
    rs1852039431,2
    C--40004239(+) CTCCCA/GAAGTG 1 -- us2k10--------
    rs1167433691,2
    F--40004255(+) ATTACC/TGGCGT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs342880131,2
    C--40004297(+) TTTTTTTT/-TTTTT 2 -- us2k1 cds11Minor allele frequency- -:0.50NA 2
    rs1400757391,2
    C--40004409(+) TGAAAA/GCAAGT 1 -- us2k10--------
    rs1899210871,2
    --40004432(+) TACCGA/TACCAA 1 -- us2k10--------
    rs1120987981,2
    C,F--40004609(+) AAAAAT/AGTTTT 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs48032541,2
    C,F,A,H--40004640(+) GCTTAC/TAAAAA 1 -- us2k123Minor allele frequency- T:0.37NA NS EA WA CSA 2482

    HapMap Linkage Disequilibrium report for SELV (40005753 - 40011326 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SELV:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv522811CNV Loss19592680
    dgv3863n71CNV Loss21882294
    dgv3864n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607919    OMIM disorders: --

    3 diseases for SELV:    About MalaCards
    staphyloenterotoxemia    chronic lymphocytic leukemia    leukemia

    1 disease from the University of Copenhagen DISEASES database for SELV:
    Staphyloenterotoxemia

    SELV for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: SELV (1 document)

    Export disorders for SELV gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SELV gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SELV)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Characterization of mammalian selenoproteomes. (PubMed id 12775843)1, 2 Kryukov G.V.... Gladyshev V.N. (2003)
    3. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    4. Single nucleotide polymorphisms of matrix metalloprot einase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study E piLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (2010)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Selenoproteins and maternal nutrition. (PubMed id 18790070)9 Pappas A.C....Zervas G. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 348303 AceView: SELV Ensembl:ENSG00000186838 euGenes: HUgn348303

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SELV gene:
    Search GeneIP for patents involving SELV

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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