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SELV Gene

protein-coding   GIFtS: 40
GCID: GC19P040005

Selenoprotein V


  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Selenoprotein V2
SelV3

External Ids:    Entrez Gene: 3483032   Ensembl: ENSG000001868387   OMIM: 6079195   UniProtKB: P597973   

Export aliases for SELV gene to outside databases

Previous GC identifers: GC19P044681 GC19P044697


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SELV Gene:
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The
selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of
selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for
the recognition of UGA as a Sec codon rather than as a stop signal. (provided by RefSeq, Jul 2008)

GeneCards Summary for SELV Gene:
SELV is a protein-coding gene. Diseases associated with SELV include staphyloenterotoxemia, and chronic lymphocytic leukemia. GO annotations related to this gene include selenium binding. An important paralog of this gene is SEPW1.

UniProtKB/Swiss-Prot: SELV_HUMAN, P59797
Function: May be involved in a redox-related process (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SELV gene promoter:
         E2F-4   E2F-3a   E2F-5   Pax-5   E2F-2   c-Ets-1   CREB   E2F   E2F-1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSELV promoter sequence
   Search Chromatin IP Primers for SELV

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SELV


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   

SELV Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SELV gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P040005:  view genomic region     (about GC identifiers)

Start:
40,005,753 bp from pter      End:
40,011,326 bp from pter
Size:
5,574 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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UniProtKB/Swiss-Prot: SELV_HUMAN, P59797 (See protein sequence)
Recommended Name: Selenoprotein V  
Size: 346 amino acids; 36800 Da
Secondary accessions: Q17RG5

Explore the universe of human proteins at neXtProt for SELV: NX_P59797

Explore proteomics data for SELV at MOPED


See SELV Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_874363.1  
ENSEMBL proteins: 
 ENSP00000333956   ENSP00000470671   ENSP00000412508  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR011893 Selenoprotein_Rdx-typ
 IPR012336 Thioredoxin-like_fold

Graphical View of Domain Structure for InterPro Entry P59797

ProtoNet protein and cluster: P59797

UniProtKB/Swiss-Prot: SELV_HUMAN, P59797
Similarity: Belongs to the SelWTH family


SELV for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: SELV_HUMAN, P59797
Function: May be involved in a redox-related process (Potential)

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008430selenium binding IEA--
     
SELV for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for SELV:
 Decreased viability with pacli  Increased gamma-H2AX phosphory 

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion2
cytosol1
nucleus1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for SELV About    
See pathways by source

SuperPathContained pathways About
1Selenium Pathway
Selenium Pathway
2Selenium Metabolism and Selenoproteins
Selenium Metabolism and Selenoproteins


2 BioSystems Pathways for SELV
    Selenium Metabolism and Selenoproteins
Selenium Pathway


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Interactions:

    Search GeneGlobe Interaction Network for SELV

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0045454cell redox homeostasis IEA--

SELV for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for SELV



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for SELV gene: 
NM_182704.1  

Unigene Cluster for SELV:

Selenoprotein V
Hs.319284  [show with all ESTs]
Unigene Representative Sequence: AY324825
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000335426(uc021uum.1) ENST00000597876 ENST00000600586 ENST00000423711

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Additional mRNA sequence: 

AY324825.1 BC117331.1 

2 DOTS entries:

DT.101977793  DT.91813866 

4 AceView cDNA sequences:

AY324825 NM_182704 BM563444 BF056261 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SELV expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCCTGGTTCC
SELV Expression
About this image

SELV Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SELV Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.319284

UniProtKB/Swiss-Prot: SELV_HUMAN, P59797
Tissue specificity: Testis specific

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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELV

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for SELV gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia BC0894911 , 5 cDNA sequence BC0894911, 5 59.3(n)1
48.18(a)1
  7 (16.67 cM)5
2806211  NM_175033.31  NP_778198.21 
 282846525 
zebrafish
(Danio rerio)
Actinopterygii sepw16
selenoprotein W, 1
47(a)
1 → many
5(65060414-65066854) ENSDARG00000035136


ENSEMBL Gene Tree for SELV (if available)
TreeFam Gene Tree for SELV (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SELV gene
SEPW12  
1 SIMAP similar gene for SELV using alignment to 3 protein entries:     SELV_HUMAN (see all proteins):
SEPW1

SELV for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SELV (see all 206)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs589497441,2
C,F--40003819(+) CACAAT/ACACAG 1 -- us2k12Minor allele frequency- A:0.15WA 120
rs1443014571,2
C--40003853(+) CATCCA/CGGCCA 1 -- us2k10--------
rs1511798221,2
C--40003928(+) GCAGTA/GGTGTG 1 -- us2k10--------
rs1852039431,2
C--40004239(+) CTCCCA/GAAGTG 1 -- us2k10--------
rs1167433691,2
F--40004255(+) ATTACC/TGGCGT 1 -- us2k11Minor allele frequency- T:0.01WA 118
rs342880131,2
C--40004297(+) TTTTTTTT/-TTTTT 2 -- us2k1 cds11Minor allele frequency- -:0.50NA 2
rs1400757391,2
C--40004409(+) TGAAAA/GCAAGT 1 -- us2k10--------
rs1899210871,2
--40004432(+) TACCGA/TACCAA 1 -- us2k10--------
rs1120987981,2
C,F--40004609(+) AAAAAT/AGTTTT 1 -- us2k11Minor allele frequency- A:0.50NA 2
rs48032541,2
C,F,A,H--40004640(+) GCTTAC/TAAAAA 1 -- us2k123Minor allele frequency- T:0.37NA NS EA WA CSA 2482

HapMap Linkage Disequilibrium report for SELV (40005753 - 40011326 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for SELV:    About this table    
Variant IDTypeSubtypePubMed ID
nsv522811CNV Loss19592680
dgv3863n71CNV Loss21882294
dgv3864n71CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607919    OMIM disorders: --

3 diseases for SELV:    
About MalaCards
staphyloenterotoxemia    chronic lymphocytic leukemia    leukemia

1 disease from the University of Copenhagen DISEASES database for SELV:
Staphyloenterotoxemia

SELV for disorders           About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: SELV (1 document)

Export disorders for SELV gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SELV gene integrated from 10 sources:
(articles sorted by number of sources associating them with SELV)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Characterization of mammalian selenoproteomes. (PubMed id 12775843)1, 2 Kryukov G.V.... Gladyshev V.N. (Science 2003)
  3. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
  4. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (Haematologica 2011)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  6. Selenoproteins and maternal nutrition. (PubMed id 18790070)9 Pappas A.C....Zervas G. (amp 2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 348303 AceView: SELV Ensembl:ENSG00000186838 euGenes: HUgn348303

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SELV gene:
Search GeneIP for patents involving SELV

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELV
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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