SELV Gene
protein-coding GIFtS: 38
GCID: GC19P040005
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|
SELV
| |
Aliases
for SELV gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Selenoprotein V2 | | SelV3 |
Export aliases for SELV gene to outside databasesPrevious GC identifers: GC19P044681 GC19P044697 |
Summaries
for SELV gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SELV:
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteineis encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have acommon stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Seccodon rather than as a stop signal. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SELV_HUMAN, P59797Function: May be involved in a redox-related process (Potential)
|
Genomic Views
for SELV gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SELV gene promoter:
E2F-4 E2F-3a E2F-5 Pax-5 E2F-2 c-Ets-1 CREB E2F E2F-1 deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for SELV
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SELV |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 SELV Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P040005: view genomic region
(about GC identifiers)
Start:
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40,005,753 bp from pter |
End:
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40,011,326 bp from pter |
Size:
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5,574 bases |
Orientation:
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plus strand |
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Proteins
for SELV gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SELV_HUMAN, P59797 (See
protein sequence)Recommended Name: Selenoprotein V Size: 346 amino acids; 36800 Da
Secondary accessions: Q17RG5Explore the universe of human proteins at neXtProt for SELV: NX_P59797
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P59797
SELV Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_874363.1
ENSEMBL proteins: ENSP00000333956 ENSP00000412508
Human Recombinant Protein Products for SELV:
SELV Antibody Products:
Assay Products for SELV: |
Protein
Domains /
Families
for SELV gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SELV for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P59797ProtoNet protein and cluster: P59797 UniProtKB/Swiss-Prot: SELV_HUMAN, P59797Similarity: Belongs to the SelWTH family |
Function
for SELV gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SELV_HUMAN, P59797Function: May be involved in a redox-related process (Potential) Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008430 | selenium binding |
IEA | -- |
SELV for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for SELV:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SELV (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SELV (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SELV (NM_182704) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SELV | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELV |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELV |
|
Pathways & Interactions
for SELV gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Selenium Metabolism and Selenoproteins | | | 2 | Selenium Pathway | |
2  BioSystems Pathways for SELV
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SELV
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045454 | cell redox homeostasis |
IEA | -- |
SELV for ontologies About GeneDecksing
|
Drugs & Compounds
for SELV gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SELV
Search CenterWatch for drugs/clinical trials and news about SELV
|
Transcripts
for SELV gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SELV gene: NM_182704.1 Unigene Cluster for SELV: Selenoprotein V Hs.319284 [show with all ESTs]Unigene Representative Sequence: AY3248252 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000335426(uc021uum.1) ENST00000423711
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SELV (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SELV (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SELV (NM_182704) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SELV | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELV |
Additional cDNA sequence: AY324825.1 BC117331.1 2 DOTS entries: DT.101977793 DT.91813866 4 AceView cDNA sequences: NM_182704 AY324825 BM563444 BF056261
GeneLoc Exon Structure
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Expression
for SELV gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SELV expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCTGGTTCC
About this image
See SELV Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.319284
UniProtKB/Swiss-Prot: SELV_HUMAN, P59797Tissue specificity: Testis specific
SABiosciences Custom PCR Arrays for SELV
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SELV
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SELV | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SELV | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SELV | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELV |
Orthologs
for SELV gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SELV gene from 5/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
BC0894911 , 5 |
cDNA sequence BC0894911, 5 |
63.66(n)1
51.61(a)1 |
|
7 (16.67 cM)5
2806211 NM_175033.31 NP_778198.21
282846525 |
zebrafish
(Danio rerio) |
Actinopterygii |
CT583679.26 |
-- |
9(a) |
1 ↔ 1 |
8(2339423-2351314) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG437106 |
-- |
6(a) |
1 ↔ 1 |
2R(16664232-16665254) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G149206 |
gibberellin-regulated protein |
10(a) |
1 ↔ 1 |
5(4826479-4827980) |
rice
(Oryza sativa) |
Liliopsida |
-- |
LTPL109 - Protease inhibitor/seed storage/LTP fami... |
13(a) |
1 ↔ 1 |
7(22403287-22404216) |
ENSEMBL Gene Tree for SELV (if available)
TreeFam Gene Tree for SELV (if available) |
Paralogs
for SELV gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SELV gene
- SEPW12
1 SIMAP similar gene for SELV using alignment to 3 protein entries: SELV_HUMAN (see all proteins):SEPW1
SELV for paralogs About GeneDecksing
|
Genomic Variants
for SELV gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SELV (40005753 - 40011326 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SELV: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SELV |
|
Disorders
/ Diseases
for SELV gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SELV for disorders About GeneDecksing
OMIM gene information: 607919
OMIM disorders: --
4  diseases for SELV: About MalaCardsstaphyloenterotoxemia chronic lymphocytic leukemia lymphocytic leukemia leukemia
1 disease from the University of Copenhagen DISEASES database for SELV:Staphyloenterotoxemia Human Genome Epidemiology (HuGE) Navigator: SELV (1 document)
Export disorders for SELV gene to outside databases
|
Publications
for SELV gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SELV gene integrated from 9 sources:
(articles sorted by number of sources associating them with SELV) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Characterization of mammalian selenoproteomes. (PubMed id 12775843)1, 2 Kryukov G.V.... Gladyshev V.N. (2003)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Single nucleotide polymorphisms of matrix metalloprot einase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study E piLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (2010)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Selenoproteins and maternal nutrition. (PubMed id 18790070)9 Pappas A.C....Zervas G. (2008)
|
External Searches for SELV gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SELV gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SELV gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SELV gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SELV gene:
Search GeneIP for patents involving SELV
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SELV gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SELV | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SELV | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SELV | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SELV | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SELV | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SELV | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SELV | | OriGene Custom Protein Services for SELV | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SELV | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SELV | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SELV | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SELV | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SELV | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SELV |
| |
 |  |  |  | |
| | | | Search Tocris compounds for SELV |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | SELV Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELV |
|  |  |  |  | | | | Search ThermoFisher Antibodies for SELV |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELV |
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