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Aliases for SELV Gene

Aliases for SELV Gene

  • Selenoprotein V 3 5
  • SelV 4

External Ids for SELV Gene

Previous GeneCards Identifiers for SELV Gene

  • GC19P044681
  • GC19P044697
  • GC19P040005

Summaries for SELV Gene

Entrez Gene Summary for SELV Gene

  • This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]

GeneCards Summary for SELV Gene

SELV (Selenoprotein V) is a Protein Coding gene. Among its related pathways are Selenium Metabolism and Selenoproteins and Selenium Pathway. GO annotations related to this gene include selenium binding. An important paralog of this gene is SEPW1.

UniProtKB/Swiss-Prot for SELV Gene

  • May be involved in a redox-related process.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELV Gene

Genomics for SELV Gene

Regulatory Elements for SELV Gene

Enhancers for SELV Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SELV on UCSC Golden Path with GeneCards custom track

Promoters for SELV Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SELV on UCSC Golden Path with GeneCards custom track

Genomic Location for SELV Gene

Chromosome:
19
Start:
39,515,113 bp from pter
End:
39,520,686 bp from pter
Size:
5,574 bases
Orientation:
Plus strand

Genomic View for SELV Gene

Genes around SELV on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELV Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELV Gene

Proteins for SELV Gene

  • Protein details for SELV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59797-SELV_HUMAN
    Recommended name:
    Selenoprotein V
    Protein Accession:
    P59797
    Secondary Accessions:
    • Q17RG5

    Protein attributes for SELV Gene

    Size:
    346 amino acids
    Molecular mass:
    36800 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SELV Gene

Proteomics data for SELV Gene at MOPED

Post-translational modifications for SELV Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SELV Gene

No data available for DME Specific Peptides for SELV Gene

Domains & Families for SELV Gene

Protein Domains for SELV Gene

Suggested Antigen Peptide Sequences for SELV Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59797

UniProtKB/Swiss-Prot:

SELV_HUMAN :
  • Belongs to the SelWTH family.
Family:
  • Belongs to the SelWTH family.
genes like me logo Genes that share domains with SELV: view

No data available for Gene Families for SELV Gene

Function for SELV Gene

Molecular function for SELV Gene

UniProtKB/Swiss-Prot Function:
May be involved in a redox-related process.
genes like me logo Genes that share phenotypes with SELV: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SELV Gene

Localization for SELV Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SELV Gene

Pathways & Interactions for SELV Gene

genes like me logo Genes that share pathways with SELV: view

Pathways by source for SELV Gene

2 BioSystems pathways for SELV Gene

Gene Ontology (GO) - Biological Process for SELV Gene

None

No data available for SIGNOR curated interactions for SELV Gene

Drugs & Compounds for SELV Gene

No Compound Related Data Available

Transcripts for SELV Gene

mRNA/cDNA for SELV Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SELV Gene

Selenoprotein V:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SELV Gene

No ASD Table

Relevant External Links for SELV Gene

GeneLoc Exon Structure for
SELV

Expression for SELV Gene

mRNA expression in normal human tissues for SELV Gene

mRNA differential expression in normal tissues according to GTEx for SELV Gene

This gene is overexpressed in Testis (x37.2) and Thyroid (x6.9).

Protein differential expression in normal tissues from HIPED for SELV Gene

This gene is overexpressed in Pancreas (50.6) and Peripheral blood mononuclear cells (18.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SELV Gene



SOURCE GeneReport for Unigene cluster for SELV Gene Hs.319284

mRNA Expression by UniProt/SwissProt for SELV Gene

P59797-SELV_HUMAN
Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with SELV: view

Protein tissue co-expression partners for SELV Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SELV Gene

Orthologs for SELV Gene

This gene was present in the common ancestor of chordates.

Orthologs for SELV Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC102151122 35
  • 72 (n)
  • 59.56 (a)
-- 36
  • 16 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SELV 35
  • 99.04 (n)
  • 99.13 (a)
SELV 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Selv 35
  • 60.34 (n)
  • 48.87 (a)
cow
(Bos Taurus)
Mammalia SELV 36
  • 43 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC089491 36
  • 43 (a)
OneToOne
BC089491 16
BC089491 35
  • 59.3 (n)
  • 48.18 (a)
zebrafish
(Danio rerio)
Actinopterygii sepw1 36
  • 47 (a)
OneToMany
Species with no ortholog for SELV:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SELV Gene

ENSEMBL:
Gene Tree for SELV (if available)
TreeFam:
Gene Tree for SELV (if available)

Paralogs for SELV Gene

Paralogs for SELV Gene

(1) SIMAP similar genes for SELV Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SELV: view

Variants for SELV Gene

Sequence variations from dbSNP and Humsavar for SELV Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs56149652 - 39,518,756(+) GAAAA(A/G)GAGCC reference, missense
rs8102247 -- 39,517,478(+) gatcc(A/G)tactg intron-variant
rs66888920 -- 39,517,991(+) AAAAA(A/G)GCCCA intron-variant
rs67258272 -- 39,518,270(+) CGTCT(-/CAAAAAAA)CAAAA intron-variant
rs71356859 -- 39,518,181(+) CAGGA(A/G)AATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SELV Gene

Variant ID Type Subtype PubMed ID
dgv3863n71 CNV Loss 21882294
dgv3864n71 CNV Loss 21882294
nsv522811 CNV Loss 19592680

Variation tolerance for SELV Gene

Gene Damage Index Score: 3.58; 56.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELV Gene

HapMap Linkage Disequilibrium report
SELV

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELV Gene

Disorders for SELV Gene

Relevant External Links for SELV

Human Genome Epidemiology (HuGE) Navigator
SELV

No disorders were found for SELV Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SELV Gene

Publications for SELV Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3
  4. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PMID: 21048031) Casabonne D. … de Sanjose S. (Haematologica 2011) 3
  5. Selenoproteins and maternal nutrition. (PMID: 18790070) Pappas A.C. … Zervas G. (Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 2008) 23

Products for SELV Gene

Sources for SELV Gene

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