Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SELT Gene

Aliases for SELT Gene

  • Selenoprotein T 3 5
  • SelT 4

External Ids for SELT Gene

Previous GeneCards Identifiers for SELT Gene

  • GC03U900030
  • GC03P151602
  • GC03P151641
  • GC03P151803
  • GC03P150321

Summaries for SELT Gene

Entrez Gene Summary for SELT Gene

  • This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]

GeneCards Summary for SELT Gene

SELT (Selenoprotein T) is a Protein Coding gene. Among its related pathways are Selenium Metabolism and Selenoproteins and Selenium Pathway. GO annotations related to this gene include selenium binding.

Gene Wiki entry for SELT Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELT Gene

Genomics for SELT Gene

Regulatory Elements for SELT Gene

Enhancers for SELT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SELT on UCSC Golden Path with GeneCards custom track

Promoters for SELT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SELT Gene

Chromosome:
3
Start:
150,602,875 bp from pter
End:
150,630,447 bp from pter
Size:
27,573 bases
Orientation:
Plus strand

Genomic View for SELT Gene

Genes around SELT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELT Gene

Proteins for SELT Gene

  • Protein details for SELT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62341-SELT_HUMAN
    Recommended name:
    Selenoprotein T
    Protein Accession:
    P62341
    Secondary Accessions:
    • O95904
    • Q8IY80
    • Q9CZ45
    • Q9NZJ3

    Protein attributes for SELT Gene

    Size:
    195 amino acids
    Molecular mass:
    22324 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD20063.1; Type=Erroneous termination; Positions=49; Note=Translated as Sec.; Evidence={ECO:0000305}; Sequence=AAF13696.1; Type=Frameshift; Positions=27; Evidence={ECO:0000305}; Sequence=AAQ88462.1; Type=Erroneous termination; Positions=49; Note=Translated as Sec.; Evidence={ECO:0000305}; Sequence=AAQ88463.1; Type=Erroneous termination; Positions=49; Note=Translated as Sec.; Evidence={ECO:0000305};

neXtProt entry for SELT Gene

Post-translational modifications for SELT Gene

  • May contain a selenide-sulfide bond between Cys-46 and Sec-49. This bond is speculated to serve as redox-active pair (By similarity).
  • Ubiquitination at Lys 32
  • Modification sites at PhosphoSitePlus

Other Protein References for SELT Gene

No data available for DME Specific Peptides for SELT Gene

Domains & Families for SELT Gene

Protein Domains for SELT Gene

Suggested Antigen Peptide Sequences for SELT Gene

Graphical View of Domain Structure for InterPro Entry

P62341

UniProtKB/Swiss-Prot:

SELT_HUMAN :
  • Belongs to the SelWTH family. SELT subfamily.
Family:
  • Belongs to the SelWTH family. SELT subfamily.
genes like me logo Genes that share domains with SELT: view

No data available for Gene Families for SELT Gene

Function for SELT Gene

Gene Ontology (GO) - Molecular Function for SELT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008430 selenium binding NAS 10567350
genes like me logo Genes that share ontologies with SELT: view
genes like me logo Genes that share phenotypes with SELT: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SELT Gene

Localization for SELT Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SELT Gene

Pathways & Interactions for SELT Gene

genes like me logo Genes that share pathways with SELT: view

Pathways by source for SELT Gene

2 BioSystems pathways for SELT Gene

Interacting Proteins for SELT Gene

Gene Ontology (GO) - Biological Process for SELT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001514 selenocysteine incorporation NAS 10567350
GO:0009749 response to glucose IEA --
GO:0031016 pancreas development IEA --
GO:0035773 insulin secretion involved in cellular response to glucose stimulus IEA --
GO:0042593 glucose homeostasis IEA --
genes like me logo Genes that share ontologies with SELT: view

No data available for SIGNOR curated interactions for SELT Gene

Drugs & Compounds for SELT Gene

(1) Drugs for SELT Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with SELT: view

Transcripts for SELT Gene

Unigene Clusters for SELT Gene

Selenoprotein T:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELT Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8
SP1: - - -
SP2: - -
SP3: - -
SP4: - -

Relevant External Links for SELT Gene

GeneLoc Exon Structure for
SELT

Expression for SELT Gene

mRNA expression in normal human tissues for SELT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SELT Gene

This gene is overexpressed in Bone (12.7) and Islet of Langerhans (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SELT Gene



Protein tissue co-expression partners for SELT Gene

- Elite partner

SOURCE GeneReport for Unigene cluster for SELT Gene:

Hs.369052

mRNA Expression by UniProt/SwissProt for SELT Gene:

P62341-SELT_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with SELT: view

Primer Products

No data available for mRNA differential expression in normal tissues for SELT Gene

Orthologs for SELT Gene

This gene was present in the common ancestor of animals.

Orthologs for SELT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SELT 34
  • 95.9 (n)
  • 98.46 (a)
SELT 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SELT 34
  • 96.07 (n)
  • 97.44 (a)
SELT 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Selt 34
  • 95.21 (n)
  • 99.49 (a)
Selt 16
Selt 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Selt 34
  • 95.21 (n)
  • 99.49 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves SELT 34
  • 86.96 (n)
  • 91.85 (a)
SELT 35
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75917 34
selt 34
  • 82.97 (n)
  • 88.46 (a)
zebrafish
(Danio rerio)
Actinopterygii selt1a 34
  • 75.51 (n)
  • 79.01 (a)
sept1a 34
selt1a 35
  • 75 (a)
OneToMany
selt1b 35
  • 75 (a)
OneToMany
selt2 35
  • 46 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8427 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009202 34
  • 52.16 (n)
  • 43.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3887 34
  • 53.67 (n)
  • 41.24 (a)
CG3887 35
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C35C5.3 35
  • 24 (a)
OneToMany
F28H7.4 35
  • 23 (a)
OneToMany
Species where no ortholog for SELT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SELT Gene

ENSEMBL:
Gene Tree for SELT (if available)
TreeFam:
Gene Tree for SELT (if available)

Paralogs for SELT Gene

Pseudogenes.org Pseudogenes for SELT Gene

genes like me logo Genes that share paralogs with SELT: view

No data available for Paralogs for SELT Gene

Variants for SELT Gene

Sequence variations from dbSNP and Humsavar for SELT Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs3858 -- 150,628,246(-) AGTAG(C/T)TCTCT utr-variant-3-prime
rs7979 -- 150,630,046(+) ACATG(A/G)TTTTA utr-variant-3-prime
rs1464517 -- 150,625,108(-) cagag(A/G)taaag intron-variant
rs1058455 -- 150,629,648(+) ATCTT(G/T)TGGAG utr-variant-3-prime
rs6777911 -- 150,628,867(+) TAGGA(A/G)AAGTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SELT Gene

Variant ID Type Subtype PubMed ID
esv3569056 CNV loss 25503493
nsv963367 CNV duplication 23825009

Variation tolerance for SELT Gene

Residual Variation Intolerance Score: 43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.06% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SELT Gene

Disorders for SELT Gene

No disorders were found for SELT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for SELT Gene

Publications for SELT Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 65
  3. New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements. (PMID: 10567350) Kryukov G.V. … Gladyshev V.N. (J. Biol. Chem. 1999) 3 4 65
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  5. The PACAP-regulated gene selenoprotein T is abundantly expressed in mouse and human I^-cells and its targeted inactivation impairs glucose tolerance. (PMID: 23913443) Prevost G. … Anouar Y. (Endocrinology 2013) 3 65

Products for SELT Gene

Sources for SELT Gene

Content
Loading form....