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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SELRC1 Gene

protein-coding   GIFtS: 40
GCID: GC01M053153

Sel1 Repeat Containing 1

(Previous name: chromosome 1 open reading frame 163)
(Previous symbol: C1orf163)
  Search for SELRC1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sel1 Repeat Containing 11 2
C1orf1631 2 3
Beta-Lactamase Hcp-Like Protein2 3
Chromosome 1 Open Reading Frame 1631
Hcp Beta-Lactamase-Like Protein C1orf1632
Sel1 Repeat-Containing Protein 12

External Ids:    HGNC: 257161   Entrez Gene: 652602   Ensembl: ENSG000001623777   UniProtKB: Q96BR53   

Export aliases for SELRC1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SELRC1 Gene: 
SELRC1 (Sel1 repeat containing 1) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SELRC1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSELRC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SELRC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SELRC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.3   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

SELRC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SELRC1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M053153:  view genomic region     (about GC identifiers)

Start:
53,152,014 bp from pter      End:
53,164,038 bp from pter
Size:
12,025 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SELR1_HUMAN, Q96BR5 (See protein sequence)
Recommended Name: Sel1 repeat-containing protein 1  
Size: 231 amino acids; 25709 Da
Secondary accessions: Q0P6I7 Q9H9Z9

Explore the universe of human proteins at neXtProt for SELRC1: NX_Q96BR5

Explore proteomics data for SELRC1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96BR5

  • SELRC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SELRC1 Protein Expression
    REFSEQ proteins: NP_075565.2  
    ENSEMBL proteins: 
     ENSP00000360593  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR006597 Sel1-like

    Graphical View of Domain Structure for InterPro Entry Q96BR5

    ProtoNet protein and cluster: Q96BR5

    UniProtKB/Swiss-Prot: SELR1_HUMAN, Q96BR5
    Similarity: Belongs to the hcp beta-lactamase family
    Similarity: Contains 5 Sel1-like repeats


    SELRC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SELRC1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SELRC1 
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    SwitchGear 3'UTR luciferase reporter plasmidSELRC1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SELRC1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for SELRC1 (Q96BR53 ENSP000003605934) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MINOS1Q5TGZ03, ENSP000003255624I2D: score=1 STRING: ENSP00000325562
    AMACRQ9UHK63I2D: score=4 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SELRC1 (SELR1)

    Search CenterWatch for drugs/clinical trials and news about SELRC1 / SELR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SELRC1 gene: 
    NM_023077.2  

    Unigene Cluster for SELRC1:

    Sel1 repeat containing 1
    Hs.349905  [show with all ESTs]
    Unigene Representative Sequence: AK023237
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371538(uc001cui.2) ENST00000486918
    miRNA
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    hsa-miR-498 hsa-miR-99a* hsa-miR-99b* hsa-miR-513a-5p hsa-miR-27a hsa-miR-331-3p hsa-miR-26b* hsa-miR-4299
    SwitchGear 3'UTR luciferase reporter plasmidSELRC1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SELRC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SELRC1
    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SELRC1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SELRC1

    Additional mRNA sequence: 

    AK022501.1 AK023237.1 AK225041.1 AK225087.1 BC005992.1 BC015313.1 

    4 DOTS entries:

    DT.70103122  DT.121395731  DT.91643294  DT.97771480 

    24/85 AceView cDNA sequences (see all 85):

    BX363302 BE122904 AU132126 AV714520 BM698175 AA884578 BM069637 BF062318 
    BQ100976 AW303624 AA954778 AW001688 AA897301 BX505217 BU735972 BM055258 
    BU624634 CK430910 CK904437 BF439817 BQ430496 BX482212 AI873172 BG179720 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SELRC1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d
    SP1:              -     -     -                                 
    SP2:                    -     -                                 
    SP3:                          -                                 
    SP4:                                                            


    ECgene alternative splicing isoforms for SELRC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SELRC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGGGGACA
    SELRC1 Expression
    About this image


    See SELRC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SELRC1

    SOURCE GeneReport for Unigene cluster: Hs.349905
        SABiosciences Custom PCR Arrays for SELRC1
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELRC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SELRC1 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Selrc11 , 5 RIKEN cDNA 2010305A19 gene5
    Sel1 repeat containing 11
    86.15(n)1
    90.48(a)1
      4 (50.44 cM)5
    698931  NM_027250.41  NP_081526.11 
     1083281405 
    chicken
    (Gallus gallus)
    Aves SELRC11 Sel1 repeat containing 1 70.87(n)
    65.65(a)
      429105  XM_001234292.2  XP_001234293.1 
    lizard
    (Anolis carolinensis)
    Reptilia SELRC16
    Uncharacterized protein
    66(a)
    1 ↔ 1
    4(114777362-114781435)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.32902 Xenopus laevis transcribed sequence with weak similarity more 70.84(n)    CA972606.1 
    zebrafish
    (Danio rerio)
    Actinopterygii selrc11 Sel1 repeat containing 1 64.04(n)
    60.96(a)
      555268  NM_001030084.1  NP_001025255.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG138651 CG13865 52.1(n)
    37.84(a)
      3355158  NM_001042858.1  NP_001036323.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK20.41 Protein ZK20.4 48.29(n)
    33.66(a)
      174784  NM_064086.3  NP_496487.1 


    ENSEMBL Gene Tree for SELRC1 (if available)
    TreeFam Gene Tree for SELRC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/318 SNPs in SELRC1 are shown (see all 318)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs75135141,2
    C--53151524(+) agccaC/Ttgcac 1 -- ds50010--------
    rs1813940541,2
    --53151696(+) CACGCC/TCAGCT 1 -- ds50010--------
    rs1166393651,2
    C,F--53151738(+) TCGTCA/CTGTTG 1 -- ds50012Minor allele frequency- C:0.07NA EA 240
    rs1860218061,2
    --53151770(+) TGACCC/TCAAGT 1 -- ds50010--------
    rs8356121,2
    C,F,A--53151802(-) ctagcG/Attttg 1 -- ds50014Minor allele frequency- A:0.29NA CSA 7
    rs1885288311,2
    --53151822(+) CATGAC/GCCACC 1 -- ds50010--------
    rs75359431,2
    C,F,H--53152020(+) AAACGG/AAAGCC 1 -- ut316Minor allele frequency- A:0.04NS NA WA 910
    rs1813124861,2
    C--53152102(+) GCTGGG/TGAGAC 1 -- ut310--------
    rs715799381,2
    C--53152123(+) TTTTGT/-AGACG 1 -- ut311Minor allele frequency- -:0.50NA 2
    rs1866232961,2
    --53152159(+) CTATCA/GCCCAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SELRC1 (53152014 - 53164038 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SELRC1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv871800CNV Loss21882294
    dgv50e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SELRC1 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with SELRC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    6. MINOS1 is a conserved component of mitofilin complexe s and required for mitochondrial function and cristae organization. (PubMed id 22114354)1 Alkhaja A.K....Deckers M. (2012)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 65260 HGNC: 25716 AceView: FLJ12439 Ensembl:ENSG00000162377 euGenes: HUgn65260
    ECgene: SELRC1 H-InvDB: SELRC1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SELRC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SELRC1 gene:
    Search GeneIP for patents involving SELRC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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