SELPLG Gene
protein-coding GIFtS: 64
GCID: GC12M109015
|
|
selectin P ligand
| |
Aliases
for SELPLG gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Selectin P Ligand1 2 3 | | CLA2 | | PSGL-11 2 3 | | Cutaneous Lymphocyte-Associated Associated Antigen2 | | CD1621 2 | | P-Selectin Glycoprotein Ligand 12 | | PSGL12 5 | | CD162 Antigen3 |
Export aliases for SELPLG gene to outside databasesPrevious GC identifers: GC12M108122 GC12M108896 GC12M108948 GC12M107518 GC12M106080 |
Summaries
for SELPLG gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SELPLG:
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-,E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a criticalrole in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endotheliaexpressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the additionof the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrantexpression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immuneresponse. Alternate splicing results in multiple transcript variants.(provided by RefSeq, Apr 2011)
UniProtKB/Swiss-Prot: SELPL_HUMAN, Q14242Function: A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- andL-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation.PSGL1 is critical for the initial leukocyte capture
Gene Wiki entry for SELPLG (P-selectin glycoprotein ligand-1)
|
Genomic Views
for SELPLG gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SELPLG gene promoter:
CREB STAT1 AP-1 deltaCREB ATF-2 STAT1beta c-Jun NF-kappaB1 STAT1alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for SELPLG
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SELPLG |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24 Ensembl cytogenetic band: 12q24.11 HGNC cytogenetic band: 12q24SELPLG Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M109015: view genomic region
(about GC identifiers)
Start:
|
109,015,671 bp from pter |
End:
|
109,027,735 bp from pter |
Size:
|
12,065 bases |
Orientation:
|
minus strand |
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Proteins
for SELPLG gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SELPL_HUMAN, Q14242 (See
protein sequence)Recommended Name: P-selectin glycoprotein ligand 1 precursor Size: 412 amino acids; 43201 Da
Subunit: Homodimer; disulfide-linked. Interaction with P-, E- and L-selectins, through their lectin/EGF domains, isrequired for promoting recruitment and rolling of leukocytes. These interactions require sialyl Lewis X glycanmodification but there is a differing dependence for tyrosine sulfations. Sulfation on Tyr-51 of PSGL1 is mostimportant for high affinity L-selectin/SELL binding while P-selectin/SELP requires sulfation on Tyr-48.E-selectin/SELE binds with much lower affinity and requires the sLe(x) epitope, but apparantly not tyrosine sulfation.Dimerization appears not to be required for P-selectin/SELP binding. Interacts with SNX20. Interacts with MSN and SYK;mediates the activation of SYK by SELPLG
Subcellular location: Membrane; Single-pass type I membrane protein
1 PDB 3D structure from  and Proteopedia  for SELPLG:1G1S (3D)
Secondary accessions: A8K2Y0 B4DQC3 B7Z5C7 J3KMX6 Q12775 Q6GTW7 Q8N7J7Alternative splicing: 2 isoforms: Q14242-1 Q14242-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SELPLG: NX_Q14242
Post-translational modifications:
Displays complex, core-2, sialylated and fucosylated O-linked oligosaccharides, at least some of which appear tocontain poly-N-acetyllactosamine with varying degrees of substitution. Mainly disialylated or neutral forms of thecore-2 tetrasaccharide, Galbeta1-->4GlcNAcbeta1-->6(Galbeta1-->3)GalNAcOH. The GlcN:GalN ratio is approximately 2:1and the Man:Fuc ratio 3:5. Contains about 14% fucose with alpha-1,3 linkage present in two forms: One species is adisialylated, monofucosylated glycan, and the other, a monosialylated, trifucosylated glycan with a polylactosaminebackbone. The fucosylated forms carry the Lewis antigen and are important for interaction with selectins and forfunctioning in leukocyte rolling. The modification containing the sialyl Lewis X glycan is on Thr-57. No sulfatedO-glycans. Some N-glycosylation1
Sulfation, in conjunction with the SLe(x)-containing glycan, is necessary for P- and L-selectin binding. High affinityP-selectin binding has a preferred requirement for the isomer sulfated on both Tyr-48 and Tyr-51, whereas L-selectinbinding requires predominantly sulfation on Tyr-51 with sulfation on Tyr-48 playing only a minor role. Thesesulfations play an important role in L- and P-selectin-mediated neutrophil recruitment, and leukocyte rolling1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14242
SELPLG Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001193538.1 NP_002997.2
ENSEMBL proteins: ENSP00000447752 ENSP00000228463 ENSP00000373614 Reactome Protein details: Q14242
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
SELPLG for ontologies About GeneDecksing
SELPLG Antibody Products:
Assay Products for SELPLG: |
Protein
Domains /
Families
for SELPLG gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SELPLG for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q14242ProtoNet protein and cluster: Q14242 |
Function
for SELPLG gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SELPL_HUMAN, Q14242Function: A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- andL-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation.PSGL1 is critical for the initial leukocyte capture Genatlas biochemistry entry for SELPLG:P-selectin glycoprotein ligand with homology to CD43 and GP1BA
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SELPLG (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SELPLG (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): SELPLG (NM_003006) | |  | Sino Biological Human cDNA Clone for SELPLG | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SELPLG | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELPLG |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELPLG |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
SELPLG for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for SELPLG:
Animal Models:
Mouse knock-outs for SELPLG: Selplgtm2Rpmc Selplgtm1Rpmc Selplgtm1Fur
7 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Selplg):
SELPLG for phenotypes About GeneDecksing
|
Pathways & Interactions
for SELPLG gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | amb2 Integrin signaling | | | 2 | Staphylococcus aureus infection | | | 3 | Cell adhesion molecules (CAMs) | | | 4 | Cell surface interactions at the vascular wall | | | 5 | Platelet activation, signaling and aggregation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for SELPLG
2 
Reactome Pathways for SELPLG
2 
Kegg Pathways (Kegg details for SELPLG):
SELPLG for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SELPLG
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/16 Interacting proteins for SELPLG (Q142421, 3 ENSP000003736144) via UniProtKB, MINT, STRING, and/or I2D (see all 16)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
SELPLG for ontologies About GeneDecksing
|
Drugs & Compounds
for SELPLG gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SELPLG for compounds About GeneDecksing
 Browse Tocris compounds for SELPLG
1 HMDB Compound for SELPLG About this table
10/34 Novoseek chemical compound relationships for SELPLG gene (see all 34) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| 4-f-glcnac |
88.6 |
5 |
16691194 (2), 14523038 (1), 12393521 (1) |
| tyrosine sulfate |
86.2 |
11 |
7559387 (2), 8621728 (2), 9725249 (1), 8626430 (1) (see all 7) |
| slex |
84 |
31 |
12847092 (4), 17947642 (3), 7585949 (2), 8923785 (2) (see all 14) |
| tbc 1269 |
74.7 |
2 |
10756228 (1) |
| polylactosamine |
57.2 |
3 |
10725346 (1), 12145302 (1) |
| sialic acid |
55.2 |
12 |
10978329 (2), 16869829 (2), 17893131 (1), 19322854 (1) (see all 7) |
| n-acetyllactosamine |
54.8 |
6 |
7521878 (3), 19996411 (1), 12393521 (1) |
| polysaccharide |
53.2 |
22 |
8621728 (3), 7585949 (2), 7559387 (1), 19665434 (1) (see all 16) |
| tyrosine |
45.8 |
58 |
12736247 (4), 9353345 (4), 11566773 (3), 12068018 (3) (see all 29) |
| n-formylmethionyl-leucylphenylalanine |
45 |
4 |
12699513 (1), 10733515 (1), 16616654 (1) |
Search CenterWatch for drugs/clinical trials and news about SELPLG / SELPL
|
Transcripts
for SELPLG gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SELPLG gene (2 alternative transcripts): NM_001206609.1 NM_003006.4 Unigene Cluster for SELPLG: Selectin P ligand Hs.591014 [show with all ESTs]Unigene Representative Sequence: NM_0012066093 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000550948 ENST00000228463 ENST00000388962(uc010sxe.2 uc001tni.3 uc021rdm.1 uc001tnh.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SELPLG (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SELPLG (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SELPLG (NM_003006) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SELPLG | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELPLG |
Additional cDNA sequence: AK098315.1 AK127638.1 AK225644.1 AK290395.1 AK295238.1 AK298738.1 AK298742.1 AK300057.1 BC029782.1 U02297.1 6 DOTS entries: DT.112586 DT.100820008 DT.100820006 DT.100022084 DT.86845901 DT.99934793 24/99 AceView cDNA sequences (see all 99): AI253630 BQ706443 BF439467 U02297 AI660380 AA044016 AK127638 BQ052596 BI490059 BC029782 CD244672 BX336104 NM_003006 BP339710 CB152067 AI499752 F05363 BX337177 AA402615 BQ707020 BU616358 BI753351 AL709850 BM683369
GeneLoc Exon Structure
|
Expression
for SELPLG gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SELPLG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCACCAAAC
About this image
See SELPLG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SELPLG
SOURCE GeneReport for Unigene cluster: Hs.591014
UniProtKB/Swiss-Prot: SELPL_HUMAN, Q14242Tissue specificity: Expressed on neutrophils, monocytes and most lymphocytes
SABiosciences Expression via Pathway-Focused PCR Arrays including SELPLG:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SELPLG
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SELPLG | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SELPLG | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SELPLG | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELPLG |
Orthologs
for SELPLG gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for SELPLG gene from 1/6 species (see all 6) About this table
ENSEMBL Gene Tree for SELPLG (if available)
TreeFam Gene Tree for SELPLG (if available) |
Paralogs
for SELPLG gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SELPLG gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SELPLG (109015671 - 109027735 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SELPLG: --
Human Gene Mutation Database (HGMD): SELPLG
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SELPLG |
|
Disorders
/ Diseases
for SELPLG gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SELPLG for disorders About GeneDecksing
OMIM gene information: 600738
OMIM disorders: --
20/44  diseases for SELPLG (see all 44): About MalaCardshuman granulocytic anaplasmosis end stage renal failure non-hodgkin lymphoma coronary heart disease
myocardial infarction mycosis fungoides ehrlichiosis bullous pemphigoid
sulfhemoglobinemia primary effusion lymphoma chronic obstructive pulmonary disease ventricular fibrillation
venous thrombosis acute myocardial infarction hemophilia cerebrovascular disease
hodgkin's lymphoma conduct disorder chronic lymphocytic leukemia multiple sclerosis
3 diseases from the University of Copenhagen DISEASES database for SELPLG:Human granulocytic anaplasmosis Sulfhemoglobinemia Vascular disease 10/31 Novoseek disease relationships for SELPLG gene (see all 31) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| inflammation |
53.7 |
41 |
14997035 (2), 9501187 (1), 11676490 (1), 15217824 (1) (see all 21) |
| human granulocytic ehrlichiosis |
43.8 |
1 |
10834846 (1) |
| thrombosis |
43.2 |
4 |
16411399 (1), 19691482 (1), 17221329 (1), 15351841 (1) |
| colon carcinoma |
23 |
1 |
11169447 (1) |
| atherosclerosis |
20.6 |
10 |
17420019 (2), 19395438 (2), 14641238 (1), 18537597 (1) |
| hemophilia a |
8.27 |
1 |
12858167 (1) |
| asthma |
7.03 |
6 |
10550733 (1), 12829015 (1), 17442334 (1), 11446618 (1) |
| promyelocytic leukemia |
6.59 |
3 |
7540063 (1), 17267403 (1) |
| cardiovascular diseases |
4.89 |
1 |
13679485 (1) |
| cancer |
4.52 |
2 |
19667060 (2) |
Genetic Association Database (GAD): SELPLG
Human Genome Epidemiology (HuGE) Navigator: SELPLG (28 documents)
Export disorders for SELPLG gene to outside databases
|
Publications
for SELPLG gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SELPLG gene, integrated from 9 sources (see all 391):
(articles sorted by number of sources associating them with SELPLG) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Expression cloning of a functional glycoprotein ligand for P- selectin. (PubMed id 7505206)1, 2, 3 Sako D....Larsen G.R. (1993)
- Noncovalent association of P-selectin glycoprotein ligand-1 and minimal determinants for binding to P-selectin. (PubMed id 10713099)1, 2, 9 Epperson T.K.... Cummings R.D. (2000)
- Turkish population data on the factor XIII Val34Leu,glycoprotein (GP)Ibalpha Kozak and P-selectin glycoprotein ligand 1 (PSGL-1) loci. (PubMed id 15386532)1, 4, 9 Hancer V.S....Nalcaci M. (2005)
- Polymorphisms in the P-selectin (CD62P) and P-selectin glycoprotein ligand-1 (PSGL-1) genes and coronary heart disease. (PubMed id 15497463)1, 4, 9 Bugert P....Kluter H. (2004)
- SELPLG gene polymorphisms in relation to plasma SELPLG levels and coronary artery disease. (PubMed id 14641238)1, 4, 9 Tregouet D.A....Tiret L. (2003)
- SLIC-1/sorting nexin 20: a novel sorting nexin that directs subcellular distribution of PSGL-1. (PubMed id 18196517)1, 2, 9 Schaff U.Y.... Simon S.I. (2008)
- Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin. (PubMed id 7559387)1, 2, 9 Wilkins P.P.... Cummings R.D. (1995)
- The P-selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, O-linked poly-N-acetyllactosamine. (PubMed id 7521878)1, 2, 9 Moore K.L....McEver R.P. (1994)
- Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin. (PubMed id 12736247)1, 2, 9 Leppaenen A.... Cummings R.D. (2003)
- Genomic organization and chromosomal localization of the gene encoding human P-selectin glycoprotein ligand. (PubMed id 7541799)1, 2, 9 Veldman G.M....Shows T.B. (1995)
|
External Searches for SELPLG gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SELPLG gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SELPLG gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SELPLG gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SELPLG | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for SELPLG | Genetics and Cytogenetics in Oncology and Haematology | | Wikipedia | http://en.wikipedia.org/wiki/P-selectin_glycoprotein_ligand-1 | | SeattleSNPs | http://pga.gs.washington.edu/data/selplg/ |
|
| | |
About This Section
| Patent Information for SELPLG gene:
Search GeneIP for patents involving SELPLG
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SELPLG gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SELPLG | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SELPLG | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SELPLG | | | OriGene Protein Over-expression Lysate for SELPLG | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SELPLG | | OriGene 3'-UTR Clone for SELPLG | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SELPLG | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SELPLG | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SELPLG | | OriGene Custom Protein Services for SELPLG | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SELPLG | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SELPLG | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SELPLG | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SELPLG | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SELPLG | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SELPLG |
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| | | | Search Tocris compounds for SELPLG |
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 | | | SELPLG Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELPLG |
|  |  |  | | | | ThermoFisher Antibody for SELPLG |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELPLG |
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