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SELPLG Gene

protein-coding   GIFtS: 65
GCID: GC12M109015

Selectin P Ligand

  See SELPLG-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Selectin P Ligand1 2 3     CLA2
PSGL-12 3     Cutaneous Lymphocyte-Associated Associated Antigen2
PSGL12 5     P-Selectin Glycoprotein Ligand 12
CD1622     CD162 Antigen3

External Ids:    HGNC: 107221   Entrez Gene: 64042   Ensembl: ENSG000001108767   OMIM: 6007385   UniProtKB: Q142423   

Export aliases for SELPLG gene to outside databases

Previous GC identifers: GC12M108122 GC12M108896 GC12M108948 GC12M107518 GC12M106080


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SELPLG Gene:
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion
molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein
plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated
platelets or endothelia expressing selectins. This protein requires two post-translational modifications,
tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its
high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated
with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript
variants.(provided by RefSeq, Apr 2011)

GeneCards Summary for SELPLG Gene:
SELPLG (selectin P ligand) is a protein-coding gene. Diseases associated with SELPLG include ehrlichiosis, and human granulocytic anaplasmosis. GO annotations related to this gene include receptor binding.

UniProtKB/Swiss-Prot: SELPL_HUMAN, Q14242
Function: A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and
L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in
inflammation. Critical for the initial leukocyte capture

Gene Wiki entry for SELPLG (P-selectin glycoprotein ligand-1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SELPLG gene promoter:
         CREB   STAT1   AP-1   deltaCREB   ATF-2   STAT1beta   c-Jun   NF-kappaB1   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSELPLG promoter sequence
   Search Chromatin IP Primers for SELPLG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SELPLG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24   Ensembl cytogenetic band:  12q24.11   HGNC cytogenetic band: 12q24

SELPLG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SELPLG gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M109015:  view genomic region     (about GC identifiers)

Start:
109,015,671 bp from pter      End:
109,027,735 bp from pter
Size:
12,065 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SELPL_HUMAN, Q14242 (See protein sequence)
Recommended Name: P-selectin glycoprotein ligand 1 precursor  
Size: 412 amino acids; 43201 Da
Subunit: Homodimer; disulfide-linked. Interaction with P-, E- and L-selectins, through their lectin/EGF domains,
is required for promoting recruitment and rolling of leukocytes. These interactions require sialyl Lewis X glycan
modification but there is a differing dependence for tyrosine sulfations. Sulfation on Tyr-51 of PSGL1 is most
important for high affinity L-selectin/SELL binding while P-selectin/SELP requires sulfation on Tyr-48.
E-selectin/SELE binds with much lower affinity and requires the sLe(x) epitope, but apparantly not tyrosine
sulfation. Dimerization appears not to be required for P-selectin/SELP binding. Interacts with SNX20. Interacts
with MSN and SYK; mediates the activation of SYK by SELPLG
1 PDB 3D structure from and Proteopedia for SELPLG:
1G1S (3D)    
Secondary accessions: A8K2Y0 B4DQC3 B7Z5C7 J3KMX6 Q12775 Q6GTW7 Q8N7J7
Alternative splicing: 2 isoforms:  Q14242-1   Q14242-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SELPLG: NX_Q14242

Explore proteomics data for SELPLG at MOPED

Post-translational modifications: 

  • Displays complex, core-2, sialylated and fucosylated O-linked oligosaccharides, at least some of which appear to
    contain poly-N-acetyllactosamine with varying degrees of substitution. Mainly disialylated or neutral forms of
    the core-2 tetrasaccharide, Galbeta1-->4GlcNAcbeta1-->6(Galbeta1-->3)GalNAcOH. The GlcN:GalN ratio is
    approximately 2:1 and the Man:Fuc ratio 3:5. Contains about 14% fucose with alpha-1,3 linkage present in two
    forms: One species is a disialylated, monofucosylated glycan, and the other, a monosialylated, trifucosylated
    glycan with a polylactosamine backbone. The fucosylated forms carry the Lewis antigen and are important for
    interaction with selectins and for functioning in leukocyte rolling. The modification containing the sialyl Lewis
    X glycan is on Thr-57. No sulfated O-glycans. Some N-glycosylation1
  • Sulfation, in conjunction with the SLe(x)-containing glycan, is necessary for P- and L-selectin binding. High
    affinity P-selectin binding has a preferred requirement for the isomer sulfated on both Tyr-48 and Tyr-51,
    whereas L-selectin binding requires predominantly sulfation on Tyr-51 with sulfation on Tyr-48 playing only a
    minor role. These sulfations play an important role in L- and P-selectin-mediated neutrophil recruitment, and
    leukocyte rolling1
  • Ubiquitination2 at Lys386
  • Glycosylation2 at Thr57, Asn65, Asn111, Ser287, Ser289, Ser290, Thr292, Asn302
  • Modification sites at PhosphoSitePlus

  • See SELPLG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001193538.1  NP_002997.2  

    ENSEMBL proteins: 
     ENSP00000447752   ENSP00000228463   ENSP00000373614  
    Reactome Protein details: Q14242

    SELPLG Human Recombinant Protein Products:

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    Sino Biological Cell Lysate for SELPLG
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SELPLG 

     
    antibodies-online proteins for SELPLG (4 products) 

     
    antibodies-online peptides for SELPLG

    SELPLG Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SELPLG
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    antibodies-online antibodies for SELPLG (128 products) 

    SELPLG Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    eBioscience ELISAs for SELPLG:  
                        Human sPSGL-1 Platinum ELISA 96 tests
    antibodies-online kits for SELPLG (30 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    ENDOLIG: Endogenous ligands

    1 InterPro protein domain:
     IPR026195 PSGL-1

    Graphical View of Domain Structure for InterPro Entry Q14242

    ProtoNet protein and cluster: Q14242


    Find genes that share domains with SELPLG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SELPL_HUMAN, Q14242
    Function: A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and
    L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in
    inflammation. Critical for the initial leukocyte capture

         Genatlas biochemistry entry for SELPLG:
    P-selectin glycoprotein ligand with homology to CD43 and GP1BA

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding NAS7505206
    GO:0005515protein binding IPI18196517
         
    Find genes that share ontologies with SELPLG           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for SELPLG:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Increased S DNA content, incre  Increased cell size 
     Increased number of mitotic ce 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Selplg):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  integument 
     mortality/aging  renal/urinary system 

    Find genes that share phenotypes with SELPLG           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SELPLG: Selplgtm2Rpmc Selplgtm1Rpmc Selplgtm1Fur

       genOway: Develop your customized and physiologically relevant rodent model for SELPLG

    miRNA
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    miRTarBase miRNAs that target SELPLG:
    hsa-mir-335-5p (MIRT017394)

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    2 qRT-PCR Assays for microRNAs that regulate SELPLG:
    hsa-miR-185* hsa-miR-591
    SwitchGear 3'UTR luciferase reporter plasmidSELPLG 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SELPLG

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    Sino Biological Human cDNA Clone for SELPLG
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SELPL_HUMAN, Q14242: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular3
    cytoskeleton2
    lysosome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7505206
    GO:0016020membrane TAS7505206
    GO:0016021integral component of membrane TAS7541799

    Find genes that share ontologies with SELPLG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SELPLG About    
    See pathways by source

    SuperPathContained pathways About
    1Hemostasis
    Hemostasis0.43
    2Staphylococcus aureus infection
    Staphylococcus aureus infection
    3Cell surface interactions at the vascular wall
    Cell surface interactions at the vascular wall
    4Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)
    5amb2 Integrin signaling
    amb2 Integrin signaling


    Find genes that share SuperPaths with SELPLG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SELPLG
        amb2 Integrin signaling


    1 Reactome Pathway for SELPLG
        Cell surface interactions at the vascular wall


    2 Kegg Pathways  (Kegg details for SELPLG):
        Cell adhesion molecules (CAMs)
    Staphylococcus aureus infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SELPLG: 
              Endothelial Cell Biology in human mouse rat
              Atherosclerosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SELPLG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for SELPLG (Q142421, 3 ENSP000003736144) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNX20Q7Z6141, 3, ENSP000003320624EBI-1030190,EBI-744896 I2D: score=1 STRING: ENSP00000332062
    ENSG00000206379O759553I2D: score=1 
    ENSG00000206480O759553I2D: score=1 
    ENSG00000230143O759553I2D: score=1 
    ENSG00000232280O759553I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS7505206
    GO:0007596blood coagulation TAS--
    GO:0050900leukocyte migration TAS--
    GO:0050901leukocyte tethering or rolling IEA--
    GO:0050902leukocyte adhesive activation ISS--

    Find genes that share ontologies with SELPLG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SELPLG (SELPL)

    1 HMDB Compound for SELPLG    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected Novoseek inferred chemical compound relationships for SELPLG gene (see all 34)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    4-f-glcnac 88.6 5 16691194 (2), 14523038 (1), 12393521 (1)
    tyrosine sulfate 86.2 11 7559387 (2), 8621728 (2), 9725249 (1), 8626430 (1) (see all 7)
    slex 84 31 12847092 (4), 17947642 (3), 7585949 (2), 8923785 (2) (see all 14)
    tbc 1269 74.7 2 10756228 (1)
    polylactosamine 57.2 3 10725346 (1), 12145302 (1)
    sialic acid 55.2 12 10978329 (2), 16869829 (2), 17893131 (1), 19322854 (1) (see all 7)
    n-acetyllactosamine 54.8 6 7521878 (3), 19996411 (1), 12393521 (1)
    polysaccharide 53.2 22 8621728 (3), 7585949 (2), 7559387 (1), 19665434 (1) (see all 16)
    tyrosine 45.8 58 12736247 (4), 9353345 (4), 11566773 (3), 12068018 (3) (see all 29)
    n-formylmethionyl-leucylphenylalanine 45 4 12699513 (1), 10733515 (1), 16616654 (1)



    Find genes that share compounds with SELPLG           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SELPLG gene (2 alternative transcripts): 
    NM_001206609.1  NM_003006.4  

    Unigene Cluster for SELPLG:

    Selectin P ligand
    Hs.591014  [show with all ESTs]
    Unigene Representative Sequence: NM_001206609
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000550948 ENST00000228463 ENST00000388962(uc010sxe.2 uc001tni.3 uc021rdm.1 uc001tnh.3)

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      QuantiTect SYBR Green Assays in human, mouse, rat SELPLG
      QuantiFast Probe-based Assays in human, mouse, rat SELPLG

    Additional mRNA sequence: 

    AK098315.1 AK127638.1 AK225644.1 AK290395.1 AK295238.1 AK298738.1 AK298742.1 AK300057.1 
    BC029782.1 U02297.1 

    6 DOTS entries:

    DT.112586  DT.100820008  DT.100820006  DT.100022084  DT.86845901  DT.99934793 

    Selected AceView cDNA sequences (see all 99):

    BQ052596 AK127638 CB152067 U02297 BX336104 BQ706443 NM_003006 BC029782 
    BF439467 AI253630 F05363 AI499752 CD244672 BI490059 AI660380 BP339710 
    AA044016 AI342637 BM683369 BX337177 AA402615 AI219984 AL549982 BQ014273 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SELPLG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCACCAAAC
    SELPLG Expression
    About this image


    SELPLG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 6 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             neutrophils   
     
     Umbilical Cord (Extraembryonic Tissues)
             umbilical cord reticulocytes   
     
     Spleen (Hematopoietic System)
    SELPLG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SELPLG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591014

    UniProtKB/Swiss-Prot: SELPL_HUMAN, Q14242
    Tissue specificity: Expressed on neutrophils, monocytes and most lymphocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SELPLG: 
              Endothelial Cell Biology in human mouse rat
              Atherosclerosis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELPLG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SELPLG gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Selplg1 , 5 selectin, platelet (p-selectin) ligand1, 5 67.11(n)1
    53.76(a)1
      5 (55.59 cM)5
    203451  NM_009151.31  NP_033177.31 
     1138177985 
    lizard
    (Anolis carolinensis)
    Reptilia SELPLG6
    selectin P ligand
    19(a)
    1 ↔ 1
    GL343913.1(36000-37421)


    ENSEMBL Gene Tree for SELPLG (if available)
    TreeFam Gene Tree for SELPLG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SELPLG (see all 327)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1811992171,2
    --109015267(+) CCCCAC/TTGCAA 2 -- ds50010--------
    rs1118957841,2
    C--109015367(+) GAATC-/T/TT  
            
    TTTTT
    2 -- ds50011CSA 2
    rs2020387351,2
    C--109015367(+) GAATC-/TTTTTTT 2 -- ds50010--------
    rs1386473531,2
    --109015517(+) CATGTA/GCCACC 2 -- ds50010--------
    rs1861068761,2
    C--109015552(+) TAGTAA/GAGACA 2 -- ds50010--------
    rs81791471,2
    F--109015566(-) ACATAG/TTGAAA 2 -- ds50012Minor allele frequency- T:0.02NS 92
    rs124266051,2
    C,A,H--109015620(+) GCCTCA/GGCCTC 2 -- ds50011Minor allele frequency- G:0.00NA 2
    rs353314631,2
    C--109015671(+) TCCCAT/-TTTTT 2 -- ut311Minor allele frequency- -:0.50CSA 2
    rs1469945841,2
    C--109015715(+) GAGGGA/TTATTG 2 -- ut310--------
    rs1391254701,2
    --109015783(+) GGAATA/GAAGTG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SELPLG (109015671 - 109027735 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SELPLG:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2746345CNV Deletion23290073
    nsv883CNV Loss18451855

    Human Gene Mutation Database (HGMD): SELPLG
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SELPLG
    DNA2.0 Custom Variant and Variant Library Synthesis for SELPLG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600738    OMIM disorders: --

    5 diseases for SELPLG:    
    About MalaCards
    ehrlichiosis    human granulocytic anaplasmosis    pustulosis palmaris et plantaris    cerebrovascular disease
    primary effusion lymphoma

    2 diseases from the University of Copenhagen DISEASES database for SELPLG:
    Human granulocytic anaplasmosis     Vascular disease

    Find genes that share disorders with SELPLG           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SELPLG gene (see all 31)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 53.7 41 14997035 (2), 9501187 (1), 11676490 (1), 15217824 (1) (see all 21)
    human granulocytic ehrlichiosis 43.8 1 10834846 (1)
    thrombosis 43.2 4 16411399 (1), 19691482 (1), 17221329 (1), 15351841 (1)
    colon carcinoma 23 1 11169447 (1)
    atherosclerosis 20.6 10 17420019 (2), 19395438 (2), 14641238 (1), 18537597 (1)
    hemophilia a 8.27 1 12858167 (1)
    asthma 7.03 6 10550733 (1), 12829015 (1), 17442334 (1), 11446618 (1)
    promyelocytic leukemia 6.59 3 7540063 (1), 17267403 (1)
    cardiovascular diseases 4.89 1 13679485 (1)
    cancer 4.52 2 19667060 (2)

    Genetic Association Database (GAD): SELPLG
    Human Genome Epidemiology (HuGE) Navigator: SELPLG (28 documents)

    Export disorders for SELPLG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SELPLG gene, integrated from 10 sources (see all 399):
    (articles sorted by number of sources associating them with SELPLG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression cloning of a functional glycoprotein ligand for P- selectin. (PubMed id 7505206)1, 2, 3 Sako D....Larsen G.R. (Cell 1993)
    2. Noncovalent association of P-selectin glycoprotein ligand-1 and minimal determinants for binding to P-selectin. (PubMed id 10713099)1, 2, 9 Epperson T.K.... Cummings R.D. (J. Biol. Chem. 2000)
    3. SELP and SELPLG genetic variation is associated with cell surface measures of SELP and SELPLG: the Atherosclerosis Risk in Communities Carotid MRI Study. (PubMed id 19395438)1, 4, 9 Volcik K.A....Boerwinkle E. (Clin. Chem. 2009)
    4. Turkish population data on the factor XIII Val34Leu,glycoprotein (GP)Ibalpha Kozak and P-selectin glycoprotein ligand 1 (PSGL-1) loci. (PubMed id 15386532)1, 4, 9 Hancer V.S....Nalcaci M. (Cell Biochem. Funct. 2005)
    5. Polymorphisms in the P-selectin (CD62P) and P-selectin glycoprotein ligand-1 (PSGL-1) genes and coronary heart disease. (PubMed id 15497463)1, 4, 9 Bugert P....KlA1ter H. (Clin. Chem. Lab. Med. 2004)
    6. SELPLG gene polymorphisms in relation to plasma SELPLG levels and coronary artery disease. (PubMed id 14641238)1, 4, 9 Tregouet D.A....Tiret L. (Ann. Hum. Genet. 2003)
    7. SLIC-1/sorting nexin 20: a novel sorting nexin that directs subcellular distribution of PSGL-1. (PubMed id 18196517)1, 2, 9 Schaff U.Y.... Simon S.I. (Eur. J. Immunol. 2008)
    8. Specific P-selectin and P-selectin glycoprotein ligand-1 genotypes/haplotypes are associated with risk of incident CHD and ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) study. (PubMed id 17420019)1, 4, 9 Volcik K.A....Boerwinkle E. (Atherosclerosis 2007)
    9. Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin. (PubMed id 7559387)1, 2, 9 Wilkins P.P.... Cummings R.D. (J. Biol. Chem. 1995)
    10. The P-selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, O-linked poly-N-acetyllactosamine. (PubMed id 7521878)1, 2, 9 Moore K.L....McEver R.P. (J. Biol. Chem. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6404 HGNC: 10722 AceView: SELPLG Ensembl:ENSG00000110876 euGenes: HUgn6404
    ECgene: SELPLG Kegg: 6404 H-InvDB: SELPLG

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SELPLG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SELPLG Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/P-selectin_glycoprotein_ligand-1
    SeattleSNPshttp://pga.gs.washington.edu/data/selplg/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SELPLG gene:
    Search GeneIP for patents involving SELPLG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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