Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SELPLG Gene

protein-coding   GIFtS: 63
GCID: GC12M109015

Selectin P Ligand

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Selectin P Ligand1 2 3     CLA2
PSGL-12 3     Cutaneous Lymphocyte-Associated Associated Antigen2
PSGL12 5     P-Selectin Glycoprotein Ligand 12
CD1622     CD162 Antigen3

External Ids:    HGNC: 107221   Entrez Gene: 64042   Ensembl: ENSG000001108767   OMIM: 6007385   UniProtKB: Q142423   

Export aliases for SELPLG gene to outside databases

Previous GC identifers: GC12M108122 GC12M108896 GC12M108948 GC12M107518 GC12M106080


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SELPLG Gene:
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion
molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein
plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated
platelets or endothelia expressing selectins. This protein requires two post-translational modifications,
tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its
high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated
with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript
variants.(provided by RefSeq, Apr 2011)

GeneCards Summary for SELPLG Gene: 
SELPLG (selectin P ligand) is a protein-coding gene. Diseases associated with SELPLG include colon carcinoma in situ, and sulfhemoglobinemia, and among its related super-pathways are Platelet activation, signaling and aggregation. GO annotations related to this gene include bacterial cell surface binding and receptor binding.

UniProtKB/Swiss-Prot: SELPL_HUMAN, Q14242
Function: A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and
L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in
inflammation. PSGL1 is critical for the initial leukocyte capture

Gene Wiki entry for SELPLG (P-selectin glycoprotein ligand-1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SELPLG gene promoter:
         CREB   STAT1   AP-1   deltaCREB   ATF-2   STAT1beta   c-Jun   NF-kappaB1   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSELPLG promoter sequence
   Search SABiosciences Chromatin IP Primers for SELPLG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SELPLG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24   Ensembl cytogenetic band:  12q24.11   HGNC cytogenetic band: 12q24

SELPLG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SELPLG gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M109015:  view genomic region     (about GC identifiers)

Start:
109,015,671 bp from pter      End:
109,027,735 bp from pter
Size:
12,065 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SELPL_HUMAN, Q14242 (See protein sequence)
Recommended Name: P-selectin glycoprotein ligand 1 precursor  
Size: 412 amino acids; 43201 Da
Subunit: Homodimer; disulfide-linked. Interaction with P-, E- and L-selectins, through their lectin/EGF domains,
is required for promoting recruitment and rolling of leukocytes. These interactions require sialyl Lewis X glycan
modification but there is a differing dependence for tyrosine sulfations. Sulfation on Tyr-51 of PSGL1 is most
important for high affinity L-selectin/SELL binding while P-selectin/SELP requires sulfation on Tyr-48.
E-selectin/SELE binds with much lower affinity and requires the sLe(x) epitope, but apparantly not tyrosine
sulfation. Dimerization appears not to be required for P-selectin/SELP binding. Interacts with SNX20. Interacts
with MSN and SYK; mediates the activation of SYK by SELPLG
Subcellular location: Membrane; Single-pass type I membrane protein
1 PDB 3D structure from and Proteopedia for SELPLG:
1G1S (3D)    
Secondary accessions: A8K2Y0 B4DQC3 B7Z5C7 J3KMX6 Q12775 Q6GTW7 Q8N7J7
Alternative splicing: 2 isoforms:  Q14242-1   Q14242-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SELPLG: NX_Q14242

Explore proteomics data for SELPLG at MOPED 

Post-translational modifications:

  • UniProtKB: Displays complex, core-2, sialylated and fucosylated O-linked oligosaccharides, at least some of which appear to
    contain poly-N-acetyllactosamine with varying degrees of substitution. Mainly disialylated or neutral forms of
    the core-2 tetrasaccharide, Galbeta1-->4GlcNAcbeta1-->6(Galbeta1-->3)GalNAcOH. The GlcN:GalN ratio is
    approximately 2:1 and the Man:Fuc ratio 3:5. Contains about 14% fucose with alpha-1,3 linkage present in two
    forms: One species is a disialylated, monofucosylated glycan, and the other, a monosialylated, trifucosylated
    glycan with a polylactosamine backbone. The fucosylated forms carry the Lewis antigen and are important for
    interaction with selectins and for functioning in leukocyte rolling. The modification containing the sialyl Lewis
    X glycan is on Thr-57. No sulfated O-glycans. Some N-glycosylation
  • UniProtKB: Sulfation, in conjunction with the SLe(x)-containing glycan, is necessary for P- and L-selectin binding. High
    affinity P-selectin binding has a preferred requirement for the isomer sulfated on both Tyr-48 and Tyr-51,
    whereas L-selectin binding requires predominantly sulfation on Tyr-51 with sulfation on Tyr-48 playing only a
    minor role. These sulfations play an important role in L- and P-selectin-mediated neutrophil recruitment, and
    leukocyte rolling
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14242

  • SELPLG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SELPLG Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001193538.1  NP_002997.2  

    ENSEMBL proteins: 
     ENSP00000447752   ENSP00000228463   ENSP00000373614  
    Reactome Protein details: Q14242
    Human Recombinant Protein Products for SELPLG: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for SELPLG (PSGL-1/CD162)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SELPLG
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SELPLG
    GenScript Custom Purified and Recombinant Proteins Services for SELPLG
    Novus Biologicals SELPLG Lysate
    Sino Biological Recombinant Protein for SELPLG
    Sino Biological Cell Lysate for SELPLG 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS7505206
    GO:0016020membrane TAS7505206
    GO:0016021integral to membrane TAS7541799

    SELPLG for ontologies           About GeneDecksing



    SELPLG Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SELPLG
    R&D Systems Antibodies for SELPLG (PSGL-1/CD162)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SELPLG
    GenScript Custom Superior Antibodies Services for SELPLG
    Novus Biologicals SELPLG Antibodies
    Abcam antibodies for SELPLG
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for SELPLG
    LSBio Antibodies in human, mouse, rat for SELPLG 

    Assay Products for SELPLG: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SELPLG
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SELPLG
    Enzo Life Sciences assays for SELPLG
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    1 InterPro protein domain:
     IPR026195 PSGL-1

    Graphical View of Domain Structure for InterPro Entry Q14242

    ProtoNet protein and cluster: Q14242


    SELPLG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SELPL_HUMAN, Q14242
    Function: A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and
    L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in
    inflammation. PSGL1 is critical for the initial leukocyte capture

         Genatlas biochemistry entry for SELPLG:
    P-selectin glycoprotein ligand with homology to CD43 and GP1BA

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding NAS7505206
    GO:0005515protein binding IPI18196517
         
    SELPLG for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for SELPLG:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Increased S DNA content, incre  Increased cell size 
     Increased number of mitotic ce 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Selplg):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  integument 
     mortality/aging  renal/urinary system 

    SELPLG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SELPLG: Selplgtm2Rpmc Selplgtm1Rpmc Selplgtm1Fur

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SELPLG 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SELPLG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SELPLG 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SELPLG 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SELPLG
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SELPLG:
    hsa-miR-185* hsa-miR-591
    SwitchGear 3'UTR luciferase reporter plasmidSELPLG 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SELPLG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SELPLG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SELPLG
    Sirion Biotech Customized adenovirus for overexpression of SELPLG

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SELPLG (see all 8)
    OriGene ORF clones in mouse, rat for SELPLG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SELPLG (NM_003006)
    Sino Biological Human cDNA Clone for SELPLG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SELPLG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELPLG
    Sirion Biotech Customized lentivirus for stable overexpression of SELPLG 
                         Customized lentivirus expression plasmids for stable overexpression of SELPLG 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SELPLG
    Search LifeMap BioReagents cell lines for SELPLG
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELPLG


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SELPLG About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Platelet activation, signaling and aggregation
    Hemostasis0.43
    2amb2 Integrin signaling
    amb2 Integrin signaling
    3Staphylococcus aureus infection
    Staphylococcus aureus infection
    4Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)
    5Cell surface interactions at the vascular wall
    Cell surface interactions at the vascular wall

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SELPLG
        amb2 Integrin signaling


    2        Reactome Pathways for SELPLG
        Hemostasis
    Cell surface interactions at the vascular wall


    2         Kegg Pathways  (Kegg details for SELPLG):
        Cell adhesion molecules (CAMs)
    Staphylococcus aureus infection


    SELPLG for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SELPLG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/20 Interacting proteins for SELPLG (Q142421, 3 ENSP000003736144) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNX20Q7Z6141, 3, ENSP000003320624EBI-1030190,EBI-744896 I2D: score=1 STRING: ENSP00000332062
    ENSG00000206379O759553I2D: score=1 
    ENSG00000206480O759553I2D: score=1 
    ENSG00000230143O759553I2D: score=1 
    ENSG00000232280O759553I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS7505206
    GO:0007596blood coagulation TAS--
    GO:0050900leukocyte migration TAS--
    GO:0050901leukocyte tethering or rolling IEA--
    GO:0050902leukocyte adhesive activation ISS--

    SELPLG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SELPLG for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SELPLG (SELPL)

    1 HMDB Compound for SELPLG    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    10/34 Novoseek inferred chemical compound relationships for SELPLG gene (see all 34)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    4-f-glcnac 88.6 5 16691194 (2), 14523038 (1), 12393521 (1)
    tyrosine sulfate 86.2 11 7559387 (2), 8621728 (2), 9725249 (1), 8626430 (1) (see all 7)
    slex 84 31 12847092 (4), 17947642 (3), 7585949 (2), 8923785 (2) (see all 14)
    tbc 1269 74.7 2 10756228 (1)
    polylactosamine 57.2 3 10725346 (1), 12145302 (1)
    sialic acid 55.2 12 10978329 (2), 16869829 (2), 17893131 (1), 19322854 (1) (see all 7)
    n-acetyllactosamine 54.8 6 7521878 (3), 19996411 (1), 12393521 (1)
    polysaccharide 53.2 22 8621728 (3), 7585949 (2), 7559387 (1), 19665434 (1) (see all 16)
    tyrosine 45.8 58 12736247 (4), 9353345 (4), 11566773 (3), 12068018 (3) (see all 29)
    n-formylmethionyl-leucylphenylalanine 45 4 12699513 (1), 10733515 (1), 16616654 (1)

    Search CenterWatch for drugs/clinical trials and news about SELPLG / SELPL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SELPLG gene (2 alternative transcripts): 
    NM_001206609.1  NM_003006.4  

    Unigene Cluster for SELPLG:

    Selectin P ligand
    Hs.591014  [show with all ESTs]
    Unigene Representative Sequence: NM_001206609
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000550948 ENST00000228463 ENST00000388962(uc010sxe.2 uc001tni.3 uc021rdm.1 uc001tnh.3)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SELPLG
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SELPLG:
    hsa-miR-185* hsa-miR-591
    SwitchGear 3'UTR luciferase reporter plasmidSELPLG 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SELPLG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SELPLG
    Clone
    Products:
         
    OriGene clones in human, mouse for SELPLG (see all 8)
    OriGene ORF clones in mouse, rat for SELPLG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SELPLG (NM_003006)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SELPLG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELPLG
    Sirion Biotech Customized lentivirus for stable overexpression of SELPLG 
                         Customized lentivirus expression plasmids for stable overexpression of SELPLG 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SELPLG
    OriGene qSTAR qPCR primer pairs in human, mouse for SELPLG
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SELPLG
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SELPLG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SELPLG

    Additional mRNA sequence: 

    AK098315.1 AK127638.1 AK225644.1 AK290395.1 AK295238.1 AK298738.1 AK298742.1 AK300057.1 
    BC029782.1 U02297.1 

    6 DOTS entries:

    DT.112586  DT.100820008  DT.100820006  DT.100022084  DT.86845901  DT.99934793 

    24/99 AceView cDNA sequences (see all 99):

    AI253630 BP339710 BQ052596 BF439467 AA044016 NM_003006 BX336104 AI499752 
    AI660380 BQ706443 U02297 F05363 CD244672 BC029782 AK127638 BI490059 
    CB152067 BX366981 BE047921 AK098315 BX340424 T28996 BI834871 AW079434 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SELPLG expression in normal human tissues (normalized intensities)      SELPLG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCACCAAAC
    SELPLG Expression
    About this image


    SELPLG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 6 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             neutrophils   
     
     Tonsil (Hematopoietic System)
             tonsil ; non-germinal center cells   
     
     Umbilical Cord (Extraembryonic Tissues)
             umbilical cord reticulocytes   
     
     Lymph (Hematopoietic System)
             lymph node ; non-germinal center cells   
     
     Spleen (Hematopoietic System)

    See SELPLG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SELPLG

    SOURCE GeneReport for Unigene cluster: Hs.591014

    UniProtKB/Swiss-Prot: SELPL_HUMAN, Q14242
    Tissue specificity: Expressed on neutrophils, monocytes and most lymphocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including SELPLG: 
              Endothelial Cell Biology in human mouse rat
              Atherosclerosis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SELPLG
    OriGene qSTAR qPCR primer pairs in human, mouse for SELPLG
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SELPLG
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SELPLG
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SELPLG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELPLG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SELPLG gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Selplg1 , 5 selectin, platelet (p-selectin) ligand1, 5 69.03(n)1
    53.81(a)1
      5 (55.59 cM)5
    203451  NM_009151.31  NP_033177.31 
     1138177985 
    lizard
    (Anolis carolinensis)
    Reptilia SELPLG6
    selectin P ligand
    21(a)
    1 ↔ 1
    GL343913.1(36000-37421)


    ENSEMBL Gene Tree for SELPLG (if available)
    TreeFam Gene Tree for SELPLG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/327 SNPs in SELPLG are shown (see all 327)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1811992171,2
    --109015267(+) CCCCAC/TTGCAA 2 -- ds50010--------
    rs1118957841,2
    C--109015367(+) GAATC-/T/TT  
            
    TTTTT
    2 -- ds50011CSA 2
    rs2020387351,2
    C--109015367(+) GAATC-/TTTTTTT 2 -- ds50010--------
    rs1386473531,2
    --109015517(+) CATGTA/GCCACC 2 -- ds50010--------
    rs1861068761,2
    C--109015552(+) TAGTAA/GAGACA 2 -- ds50010--------
    rs81791471,2
    F--109015566(-) ACATAG/TTGAAA 2 -- ds50012Minor allele frequency- T:0.02NS 92
    rs124266051,2
    C,A,H--109015620(+) GCCTCA/GGCCTC 2 -- ds50011Minor allele frequency- G:0.00NA 2
    rs353314631,2
    C--109015671(+) TCCCAT/-TTTTT 2 -- ut311Minor allele frequency- -:0.50CSA 2
    rs1469945841,2
    C--109015715(+) GAGGGA/TTATTG 2 -- ut310--------
    rs1391254701,2
    --109015783(+) GGAATA/GAAGTG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SELPLG (109015671 - 109027735 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SELPLG:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2746345CNV Deletion23290073
    nsv883CNV Loss18451855


    Human Gene Mutation Database (HGMD): SELPLG
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SELPLG
    DNA2.0 Custom Variant and Variant Library Synthesis for SELPLG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600738    OMIM disorders: --

    20/41 diseases for SELPLG (see all 41):    About MalaCards
    colon carcinoma in situ    sulfhemoglobinemia    ehrlichiosis    human granulocytic anaplasmosis
    pustulosis palmaris et plantaris    end stage renal failure    primary effusion lymphoma    cerebrovascular disease
    conduct disorder    hemophilia    bullous pemphigoid    coronary heart disease
    antiphospholipid syndrome    thrombosis    peritonitis    mycosis fungoides
    hypercholesterolemia    vasculitis    multiple sclerosis    chronic obstructive pulmonary disease

    2 diseases from the University of Copenhagen DISEASES database for SELPLG:
    Human granulocytic anaplasmosis     Vascular disease

    SELPLG for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/31 Novoseek inferred disease relationships for SELPLG gene (see all 31)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 53.7 41 14997035 (2), 9501187 (1), 11676490 (1), 15217824 (1) (see all 21)
    human granulocytic ehrlichiosis 43.8 1 10834846 (1)
    thrombosis 43.2 4 16411399 (1), 19691482 (1), 17221329 (1), 15351841 (1)
    colon carcinoma 23 1 11169447 (1)
    atherosclerosis 20.6 10 17420019 (2), 19395438 (2), 14641238 (1), 18537597 (1)
    hemophilia a 8.27 1 12858167 (1)
    asthma 7.03 6 10550733 (1), 12829015 (1), 17442334 (1), 11446618 (1)
    promyelocytic leukemia 6.59 3 7540063 (1), 17267403 (1)
    cardiovascular diseases 4.89 1 13679485 (1)
    cancer 4.52 2 19667060 (2)

    Genetic Association Database (GAD): SELPLG
    Human Genome Epidemiology (HuGE) Navigator: SELPLG (28 documents)

    Export disorders for SELPLG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SELPLG gene, integrated from 9 sources (see all 394):
    (articles sorted by number of sources associating them with SELPLG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression cloning of a functional glycoprotein ligand for P- selectin. (PubMed id 7505206)1, 2, 3 Sako D....Larsen G.R. (1993)
    2. Noncovalent association of P-selectin glycoprotein ligand-1 and minimal determinants for binding to P-selectin. (PubMed id 10713099)1, 2, 9 Epperson T.K.... Cummings R.D. (2000)
    3. SELP and SELPLG genetic variation is associated with cell surface measures of SELP and SELPLG: the Atherosclerosis Risk in Communities Carotid MRI Study. (PubMed id 19395438)1, 4, 9 Volcik K.A....Boerwinkle E. (2009)
    4. Turkish population data on the factor XIII Val34Leu,glycoprotein (GP)Ibalpha Kozak and P-selectin glycoprotein ligand 1 (PSGL-1) loci. (PubMed id 15386532)1, 4, 9 Hancer V.S....Nalcaci M. (2005)
    5. Polymorphisms in the P-selectin (CD62P) and P-selectin glycoprotein ligand-1 (PSGL-1) genes and coronary heart disease. (PubMed id 15497463)1, 4, 9 Bugert P....Kluter H. (2004)
    6. SELPLG gene polymorphisms in relation to plasma SELPLG levels and coronary artery disease. (PubMed id 14641238)1, 4, 9 Tregouet D.A....Tiret L. (2003)
    7. SLIC-1/sorting nexin 20: a novel sorting nexin that directs subcellular distribution of PSGL-1. (PubMed id 18196517)1, 2, 9 Schaff U.Y.... Simon S.I. (2008)
    8. Specific P-selectin and P-selectin glycoprotein ligand-1 genotypes/haplotypes are associated with risk of incident CHD and ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) study. (PubMed id 17420019)1, 4, 9 Volcik K.A....Boerwinkle E. (2007)
    9. Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin. (PubMed id 7559387)1, 2, 9 Wilkins P.P.... Cummings R.D. (1995)
    10. The P-selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, O-linked poly-N-acetyllactosamine. (PubMed id 7521878)1, 2, 9 Moore K.L....McEver R.P. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6404 HGNC: 10722 AceView: SELPLG Ensembl:ENSG00000110876 euGenes: HUgn6404
    ECgene: SELPLG Kegg: 6404 H-InvDB: SELPLG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SELPLG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SELPLG Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/P-selectin_glycoprotein_ligand-1
    SeattleSNPshttp://pga.gs.washington.edu/data/selplg/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SELPLG gene:
    Search GeneIP for patents involving SELPLG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of SELPLG
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for SELPLG (PSGL-1/CD162)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for SELPLG (PSGL-1/CD162)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SELPLG  
     OriGene qPCR primer pairs and template standards for SELPLG   OriGene Protein Over-expression Lysate for SELPLG  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SELPLG  
     OriGene qSTAR qPCR primer pairs in human, mouse for SELPLG   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SELPLG   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SELPLG   OriGene Custom Protein Services for SELPLG  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SELPLG
     QIAGEN SeqTarget long-range PCR primers for resequencing SELPLG
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SELPLG
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SELPLG
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SELPLG
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SELPLG
     GenScript Custom Purified and Recombinant Proteins Services for SELPLG GenScript cDNA clones with any tag delivered in your preferred vector for SELPLG
     GenScript Custom Assay Services for SELPLG GenScript Custom Superior Antibodies Services for SELPLG
     GenScript Custom overexpressing Cell Line Services for SELPLG CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SELPLG promoter
     Search Chromatin IP Primers for SELPLG
     RT2 qPCR Primer Assay in human, mouse, rat SELPLG
     GNC Network for SELPLG
     SABiosciences PCR Arrays including human, mouse, rat SELPLG
     Search Tocris compounds for SELPLG (SELPL)
     Proteins and Antibodies for SELPLG
     Cell Lysates for SELPLG
     cDNA Clones for SELPLG
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Assays for SELPLG
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SELPLG antibodies
     SELPLG lysates
     Antibodies for SELPLG
     See all of Abcam's Antibodies, Kits and Proteins for SELPLG
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for SELPLG
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELPLG
     SwitchGear 3'UTR luciferase reporter plasmids for SELPLG
     SwitchGear Promoter luciferase reporter plasmids for SELPLG
     ThermoFisher Antibodies for SELPLG
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELPLG
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SELPLG
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SELPLG
    Customized:
     lentivirus for stable overexpression of SELPLG
     lentivirus expression plasmids for stable overexpression of SELPLG
     adenovirus for overexpression of SELPLG
     LSBio Antibodies in human, mouse, rat for SELPLG
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SELPLG gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4