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SELP Gene

protein-coding   GIFtS: 72
GCID: GC01M169558

Selectin P (Granule Membrane Protein 140kDa, Antigen CD62)

(Previous names: selectin P (granule membrane protein 140kD, antigen CD62))
(Previous symbol: GRMP)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Selectin P (Granule Membrane Protein 140kDa, Antigen CD62)1 2     CD622
GRMP1 2 3 5     CD62P2
Granule Membrane Protein 1402 3     GMP1402
Leukocyte-Endothelial Cell Adhesion Molecule 32 3     P-selectin2
Platelet Activation Dependent Granule-External Membrane Protein2 3     PSEL2
GMP-1402 3     Granulocyte Membrane Protein2
LECAM32 3     Platelet Alpha-Granule Membrane Protein2
PADGEM2 3     GMRP3
CD62 Antigen-Like Family Member P2 3     CD62P Antigen3
Selectin P (Granule Membrane Protein 140kD, Antigen CD62)1     

External Ids:    HGNC: 107211   Entrez Gene: 64032   Ensembl: ENSG000001741757   OMIM: 1736105   UniProtKB: P161093   

Export aliases for SELP gene to outside databases

Previous GC identifers: GC01M167186 GC01M165208 GC01M166254 GC01M166745 GC01M166290 GC01M167824 GC01M140780


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SELP Gene:
This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of
endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation
and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is
a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on
neutrophils and monocytes. Alternative splice variants may occur but are not well documented. (provided by
RefSeq, Jul 2008)

GeneCards Summary for SELP Gene:
SELP (selectin P (granule membrane protein 140kDa, antigen CD62)) is a protein-coding gene. Diseases associated with SELP include arteriosclerosis obliterans, and platelet alpha/delta storage pool deficiency. GO annotations related to this gene include heparin binding and glycoprotein binding. An important paralog of this gene is CSMD1.

UniProtKB/Swiss-Prot: LYAM3_HUMAN, P16109
Function: Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes.
Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is
sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in
inflammation through interaction with PSGL1

summary for SELP Gene:
Cellular adhesion molecules (CAMs) are a large family of proteins that attach the cytoskeleton and
intracellular signalling cascades with the extracellular environment. CAMs have roles in cell proliferation,
differentiation, motility, trafficking, apoptosis and tissue architecture, and their dysregulation is common
in cancer. The selectins are Ca2+-dependent CAMs that bind fucosylated carbohydrates (e.g. mucins). There
are three types of selectins, E-selectin (endothelial), L-selectin (leukocyte) and P-selectin (platelet).

Gene Wiki entry for SELP (P-selectin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SELP gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSELP promoter sequence
   Search Chromatin IP Primers for SELP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SELP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22-q25   Ensembl cytogenetic band:  1q24.2   HGNC cytogenetic band: 1q22-q25

SELP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SELP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M169558:  view genomic region     (about GC identifiers)

Start:
169,558,087 bp from pter      End:
169,599,431 bp from pter
Size:
41,345 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LYAM3_HUMAN, P16109 (See protein sequence)
Recommended Name: P-selectin precursor  
Size: 830 amino acids; 90834 Da
Subunit: Interacts with SNX17. Interacts with PSGL1/SEPL and PODXL2 and mediates neutrophil adhesion and leukocyte
rolling. This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine
sulfation on PSGL1
6 PDB 3D structures from and Proteopedia for SELP:
1FSB (3D)        1G1Q (3D)        1G1R (3D)        1G1S (3D)        1HES (3D)        1KJD (3D)    
Secondary accessions: Q5R344 Q8IVD1

Explore the universe of human proteins at neXtProt for SELP: NX_P16109

Explore proteomics data for SELP at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn54, Asn98, Asn180, Asn212, Asn219, Asn411, Asn460, Asn518, Asn665, Asn716,
                                 Asn723, Asn741
  • Modification sites at PhosphoSitePlus

  • See SELP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002996.2  
    ENSEMBL proteins: 
     ENSP00000391694   ENSP00000263686   ENSP00000356760   ENSP00000399368   ENSP00000356762  
     ENSP00000356769   ENSP00000356767   ENSP00000356768   ENSP00000356766   ENSP00000356765  
    Reactome Protein details: P16109

    SELP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for SELP (P-Selectin/CD62P)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SELP
    OriGene Protein Over-expression Lysate for SELP
    OriGene MassSpec for SELP
    OriGene Custom Protein Services for SELP
    GenScript Custom Purified and Recombinant Proteins Services for SELP
    Novus Biologicals SELP Proteins
    Novus Biologicals SELP Lysates
    Sino Biological Recombinant Protein for SELP
    Sino Biological Cell Lysate for SELP
    ProSpec Recombinant Protein for SELP
    Cloud-Clone Corp. Proteins for SELP

    SELP Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for SELP (P-Selectin/CD62P)
    OriGene Antibodies for SELP
    OriGene Custom Antibody Services for SELP
    Novus Biologicals SELP Antibodies
    Abcam antibodies for SELP
    Cloud-Clone Corp. Antibodies for SELP
    ThermoFisher Antibodies for SELP
    LSBio Antibodies in human, mouse, rat for SELP

    SELP Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SELP
    R&D Systems ELISAs for SELP (P-Selectin/CD62P)         (see all)
    GenScript Custom Assay Services for SELP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SELP
    Cloud-Clone Corp. CLIAs for SELP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    Selected InterPro protein domains (see all 8):
     IPR002396 Selectin_superfamily
     IPR000742 EG-like_dom
     IPR000436 Sushi_SCR_CCP
     IPR016187 C-type_lectin_fold
     IPR018378 C-type_lectin_CS

    Graphical View of Domain Structure for InterPro Entry P16109

    ProtoNet protein and cluster: P16109

    3 Blocks protein domains:
    IPB000436 Sushi domain/SCR domain/CCP module
    IPB002396 Selectin superfamily complement-binding repeat signature
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: LYAM3_HUMAN, P16109
    Similarity: Belongs to the selectin/LECAM family
    Similarity: Contains 1 C-type lectin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 9 Sushi (CCP/SCR) domains


    SELP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LYAM3_HUMAN, P16109
    Function: Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes.
    Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is
    sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in
    inflammation through interaction with PSGL1

         Genatlas biochemistry entry for SELP:
    P selectin,leukocyte adhesion molecule,granule membrane protein (platelet,endothelium),induced by
    thrombin,histamine,peroxides from platelet alpha granule,high expressed in atherosclerotic plaques

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001530lipopolysaccharide binding IMP16514062
    GO:0001948glycoprotein binding IEA--
    GO:0005515protein binding IPI11237770
    GO:0008201heparin binding IDA7680663
    GO:0030246carbohydrate binding ----
         
    SELP for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for SELP:
     Decreased viability of wild-ty  G0/1 arrest  Increased G1 DNA content  Increased cell number in G2M,  

         15 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Selp):
     behavior/neurological  cardiovascular system  cellular  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     nervous system  renal/urinary system  respiratory system  skeleton  vision/eye 

    SELP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SELP: Selptm1Bay Selptm1Hyn Selptm2Hyn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SELP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SELP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SELP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SELP

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SELP using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate SELP:
    hsa-miR-875-3p hsa-miR-3202 hsa-miR-548q hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidSELP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SELP
    Predesigned siRNA for gene silencing in human, mouse, rat SELP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SELP

    Clone
    Products:
         
    OriGene clones in human, mouse for SELP (see all 7)
    OriGene ORF clones in mouse, rat for SELP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SELP (NM_003005)
    Sino Biological Human cDNA Clone for SELP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SELP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELP

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SELP
    Browse ESI BIO Cell Lines and PureStem Progenitors for SELP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LYAM3_HUMAN, P16109: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    nucleus4
    plasma membrane4
    cytosol3
    cytoskeleton2
    lysosome2
    endosome1
    mitochondrion1
    peroxisome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA9290466
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane TAS--

    SELP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SELP About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Response to elevated platelet cytosolic Ca2+
    Response to elevated platelet cytosolic Ca2+0.94
    Platelet degranulation0.94
    2Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    3Staphylococcus aureus infection
    Staphylococcus aureus infection
    4Spinal Cord Injury
    Spinal Cord Injury
    5Malaria
    Malaria

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for SELP
        Immune response IL-12 signaling pathway

    4 BioSystems Pathways for SELP
        Spinal Cord Injury
    IL-3 Signaling Pathway
    IL4-mediated signaling events
    amb2 Integrin signaling


    2 Reactome Pathways for SELP
        Platelet degranulation
    Cell surface interactions at the vascular wall


    3 Kegg Pathways  (Kegg details for SELP):
        Cell adhesion molecules (CAMs)
    Malaria
    Staphylococcus aureus infection


    SELP for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SELP: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cell Surface Markers in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Atherosclerosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SELP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SELP (P161093 ENSP000002636864) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EZRP153113, ENSP000003389344I2D: score=3 STRING: ENSP00000338934
    SELPLGQ142423, ENSP000003736144I2D: score=3 STRING: ENSP00000373614
    SERPING1P051553, ENSP000002784074I2D: score=3 STRING: ENSP00000278407
    VCANP136113, ENSP000002650774I2D: score=3 STRING: ENSP00000265077
    FUT4P220833, ENSP000003516024I2D: score=2 STRING: ENSP00000351602
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0002687positive regulation of leukocyte migration IEA--
    GO:0006954inflammatory response IEA--
    GO:0007155cell adhesion TAS2466574
    GO:0007157heterophilic cell-cell adhesion IEA--

    SELP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for SELP available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ThiolutinBacterial RNA polymerase inhibitor[87-11-6]
    Heparin sodium saltAnticoagulant[9041-08-1]
    Echistatin, alpha1 isoform alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor[154303-05-6]
    RGDS peptideIntegrin binding sequence; inhibits integrin receptor function[91037-65-9]
    Ac2-26Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation[151988-33-9]

    3 HMDB Compounds for SELP    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-39851547
    Clopidogrel(+)-(S)-Clopidogrel (see all 6)113665-84-2--
    Sialyl-Lewis X3'-Sialyl-Lewis X (see all 8)98603-84-0--

    4 DrugBank Compounds for SELP    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    HeparinAlpha-Heparin (see all 8)9005-49-6targetinhibitor17629851 15995351 9466983 7694675 17458940 17651117 17549299
    Nadroparin-- 9041-08-1targetinhibitor17629851 16525583
    O-Sialic Acid-- --target--17139284 17016423
    DalteparinDaltepariininatrium (see all 13)9041-08-1targetinhibitor11044537

    Selected Novoseek inferred chemical compound relationships for SELP gene (see all 138)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adp 86.4 371 7687162 (4), 7506054 (3), 15972139 (3), 17482663 (3) (see all 99)
    slex 84.1 94 12847092 (4), 15996105 (4), 8923785 (3), 10920004 (3) (see all 43)
    fibrinogen 83.2 457 11511124 (7), 7544916 (6), 7506054 (5), 10802004 (5) (see all 99)
    clopidogrel 79.2 111 12621388 (3), 16411409 (3), 12353080 (3), 19440925 (3) (see all 61)
    aspirin 74.7 138 8835129 (5), 18413191 (5), 12621388 (4), 9723822 (3) (see all 77)
    ac 12 70.4 4 8950496 (1), 7686899 (1)
    mdmp 69.6 6 15136063 (2), 12581566 (1), 15668187 (1), 14691580 (1) (see all 5)
    tyrosine sulfate 68.7 3 7559387 (1), 9725249 (1), 10978329 (1)
    abciximab 67.8 32 11152927 (3), 11422017 (3), 9869172 (2), 10674406 (2) (see all 21)
    4-f-glcnac 67.1 3 16691194 (2), 18056398 (1)



    SELP for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SELP gene: 
    NM_003005.3  

    Unigene Cluster for SELP:

    Selectin P (granule membrane protein 140kDa, antigen CD62)
    Hs.73800  [show with all ESTs]
    Unigene Representative Sequence: NM_003005
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000426706(uc001ggh.3) ENST00000263686(uc001ggi.4 uc009wvr.3)
    ENST00000466167 ENST00000367786 ENST00000458599 ENST00000367788 ENST00000367795
    ENST00000367793 ENST00000367794 ENST00000367792 ENST00000367791
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SELP using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate SELP:
    hsa-miR-875-3p hsa-miR-3202 hsa-miR-548q hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidSELP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SELP
    Predesigned siRNA for gene silencing in human, mouse, rat SELP
    Clone
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    OriGene clones in human, mouse for SELP (see all 7)
    OriGene ORF clones in mouse, rat for SELP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SELP (NM_003005)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SELP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELP
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SELP
    OriGene qSTAR qPCR primer pairs in human, mouse for SELP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SELP
      QuantiTect SYBR Green Assays in human, mouse, rat SELP
      QuantiFast Probe-based Assays in human, mouse, rat SELP

    Additional mRNA sequence: 

    AK312884.1 AY367063.1 BC028067.2 BC068533.1 M25322.1 

    7 DOTS entries:

    DT.100000000  DT.411391  DT.100019088  DT.100644300  DT.100754970  DT.121415788  DT.92418041 

    Selected AceView cDNA sequences (see all 50):

    BC068533 AA953436 BC028067 AI659868 BX110929 BQ771982 AY367063 BG400761 
    H30141 CD704975 CD616073 CB991376 CB961616 AL603469 M25322 R50714 
    BG055183 BQ003632 T70540 BQ716130 CD250696 BV183380 CB989951 BX952293 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SELP    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c · 17d
    SP1:                                                                                                  -                 -                     
    SP2:                                                                                                  -                 -                     
    SP3:                                                                                            -     -                                       
    SP4:                                                                                            -     -                 -                     
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for SELP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SELP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCACCGTGGA
    SELP Expression
    About this image


    SELP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells
     
     Adipose (Muscoskeletal System)
             Visceral White Adipose
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Megakaryocytes Hematopoietic Bone Marrow
    SELP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SELP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.73800

    UniProtKB/Swiss-Prot: LYAM3_HUMAN, P16109
    Tissue specificity: Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon
    cell activation by agonists, P-selectin is transported rapidly to the cell surface

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SELP: 
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              Endothelial Cell Biology in human mouse rat
              Atherosclerosis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SELP gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Selp1 , 5 selectin, platelet1, 5 75.23(n)1
    68.92(a)1
      1 (71.42 cM)5
    203441  NM_011347.21  NP_035477.11 
     1641152645 
    chicken
    (Gallus gallus)
    Aves SELP1 selectin P (granule membrane protein 140kDa, antigen more 53.55(n)
    43.17(a)
      424364  XM_004943139.1  XP_004943196.1 
    lizard
    (Anolis carolinensis)
    Reptilia SELP6
    selectin P (granule membrane protein 140kDa, antig...
    45(a)
    1 ↔ 1
    4(71136636-71174852)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia selp1 selectin P (granule membrane protein 140kDa, antigen more 53.91(n)
    46.47(a)
      100485005  XM_002933783.2  XP_002933829.2 
    zebrafish
    (Danio rerio)
    Actinopterygii selp1 selectin P 50.39(n)
    42.13(a)
      796481  NM_001243323.1  NP_001230252.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fw3 cell adhesion cell adhesion molecule 25(a)   11A1   --
    worm
    (Caenorhabditis elegans)
    Secernentea T07H6.53   -- 27(a)   X(6321807-6326652)   --


    ENSEMBL Gene Tree for SELP (if available)
    TreeFam Gene Tree for SELP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SELP gene
    CSMD12  C4BPA2  CR22  SELL2  CSMD32  CR1L2  APOH2  SELE2  
    CSMD22  CD462  CD552  CR12  SVEP12  
    6 SIMAP similar genes for SELP using alignment to 9 protein entries:     LYAM3_HUMAN (see all proteins):
    SELL    SELE    KLRC2    KLRG1    APOH    PROS1

    SELP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SELP (see all 1121)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs61361,2,,4
    C,F,O,Hnon-pathogenic1176116403(-) GGTCAA/CCTACC 2 T P mis1 ese333Minor allele frequency- C:0.07MN NS NA EA EU 11641
    rs1444131641,2
    Cuntested1176124758(+) CGATCA/GAGTAC 2 R * stg10--------
    rs61331,2,,4
    C,F,A,Hother1176117798(-) CAGGGC/G/TTGCAA 3 L V mis1 ese340MN NS NA EA WA CSA EU 11609
    rs32161921,2
    C--140793816(-) ATAAT-/TGGTAA 1 -- int10--------
    rs1131571691,2
    C--140813022(+) GGAGTTG/-TTGTG 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs674125221,2
    C--140813367(+) GAGGT-/TGTG  
      TGTGTG
    TGTGT
    1 -- int10--------
    rs39178751,2
    C--169558127(-) CCAAAG/CACCAA 1 -- ut31 ese34Minor allele frequency- C:0.01NS NA 94
    rs1860304011,2
    --169558142(+) TTTGAA/GGGACA 1 -- ut310--------
    rs39178561,2
    C,F--169558512(-) AAGCCA/TGGAGC 1 -- ut31 ese35Minor allele frequency- T:0.02NS NA 228
    rs1908908671,2
    --169558515(+) CCTGGC/TTTCTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SELP (169558087 - 169599431 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SELP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2516985CNV Deletion19546169
    esv2658365CNV Deletion23128226
    nsv517483CNV Loss19592680
    nsv872534CNV Loss21882294
    nsv872538CNV Gain21882294
    esv22143CNV Gain+Loss19812545

    Human Gene Mutation Database (HGMD): SELP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SELP
    DNA2.0 Custom Variant and Variant Library Synthesis for SELP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 173610   
    OMIM disorders: 147050  
    UniProtKB/Swiss-Prot: LYAM3_HUMAN, P16109
  • Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural
    tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes,
    resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of
    heterogeneous disorders with multiple genetic and environmental risk factors. Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry

  • Selected diseases for SELP (see all 192):    
    About MalaCards
    arteriosclerosis obliterans    platelet alpha/delta storage pool deficiency    intermittent claudication    carotid stenosis
    peripheral vascular disease    type 2b von willebrand disease    immune-complex glomerulonephritis    von willebrand's disease
    retinal vascular occlusion    gray platelet syndrome    quebec platelet disorder    mitral valve disease
    purpura    atopy    arteriosclerosis    vascular disease
    heparin-induced thrombocytopenia    leukocyte adhesion deficiency    proliferative glomerulonephritis    autoimmune thrombocytopenic purpura

    7 diseases from the University of Copenhagen DISEASES database for SELP:
    Vascular disease     Heart disease     Thrombocytopenia     Brain disease
    Diabetes mellitus     Peritonitis     Kidney disease

    SELP for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for SELP gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thrombosis 74.4 72 15217633 (2), 15004723 (2), 19840484 (2), 7543539 (1) (see all 56)
    inflammation 73.7 176 10410991 (5), 8691152 (3), 15991175 (2), 19125345 (2) (see all 99)
    gray platelet syndrome 72.7 1 9042822 (1)
    platelet dysfunction 71.5 5 8949396 (1), 18432525 (1), 11071121 (1), 17599498 (1) (see all 5)
    atherosclerosis 65.5 82 9391718 (4), 9241735 (3), 9034560 (3), 8584997 (2) (see all 51)
    abnormal platelets 64.5 1 10611541 (1)
    platelet aggregation, spontaneous 62.1 4 8870174 (1), 11246548 (1), 19297212 (1), 17845921 (1)
    coronary artery disease 59 39 14640893 (3), 19487018 (3), 8957206 (2), 10493220 (2) (see all 28)
    arterial thrombosis 53.4 6 15568145 (4), 19850970 (1), 15168594 (1)
    cardiovascular diseases 53.3 21 11726042 (2), 16449250 (1), 12370220 (1), 15136493 (1) (see all 18)

    Genetic Association Database (GAD): SELP
    Human Genome Epidemiology (HuGE) Navigator: SELP (120 documents)

    Export disorders for SELP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SELP gene, integrated from 10 sources (see all 2257):
    (articles sorted by number of sources associating them with SELP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SELP and SELPLG genetic variation is associated with cell surface measures of SELP and SELPLG: the Atherosclerosis Risk in Communities Carotid MRI Study. (PubMed id 19395438)1, 4, 9 Volcik K.A....Boerwinkle E. (Clin. Chem. 2009)
    2. Soluble P-selectin, SELP polymorphisms, and atherosclerotic risk in European-American and African-African young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. (PubMed id 18535285)1, 4, 9 Reiner A.P....Gross M.D. (Arterioscler. Thromb. Vasc. Biol. 2008)
    3. P-selectin polymorphisms' influences on P-selectin serum concentrations and on their familial correlation: the STANISLAS family study. (PubMed id 18363816)1, 4, 9 Marteau J.B....Visvikis-Siest S. (J. Thromb. Haemost. 2008)
    4. Clinical and genetic correlates of soluble P-selectin in the community. (PubMed id 17944986)1, 4, 9 Lee D.S....Benjamin E.J. (J. Thromb. Haemost. 2008)
    5. Specific P-selectin and P-selectin glycoprotein ligand-1 genotypes/haplotypes are associated with risk of incident CHD and ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) study. (PubMed id 17420019)1, 4, 9 Volcik K.A....Boerwinkle E. (Atherosclerosis 2007)
    6. Polymorphisms in the P-selectin (CD62P) and P-selectin glycoprotein ligand-1 (PSGL-1) genes and coronary heart disease. (PubMed id 15497463)1, 4, 9 Bugert P....KlA1ter H. (Clin. Chem. Lab. Med. 2004)
    7. Association between P-selectin gene polymorphisms and soluble P-selectin levels and their relation to coronary artery disease. (PubMed id 11597943)1, 4, 9 Barbaux S.C....Tiret L. (Arterioscler. Thromb. Vasc. Biol. 2001)
    8. Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels. (PubMed id 20167578)1, 4, 9 Barbalic M....Benjamin E.J. (Hum. Mol. Genet. 2010)
    9. SELPLG and SELP single-nucleotide polymorphisms in multiple sclerosis. (PubMed id 16257118)1, 4, 9 Fenoglio C....Sawcer S. (Neurosci. Lett. 2006)
    10. P-selectin gene haplotypes modulate soluble P-selectin concentrations and contribute to the risk of venous thromboembolism. (PubMed id 18449419)1, 4, 9 Ay C....Mannhalter C. (Thromb. Haemost. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6403 HGNC: 10721 AceView: SELP Ensembl:ENSG00000174175 euGenes: HUgn6403
    ECgene: SELP Kegg: 6403 H-InvDB: SELP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SELP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SELP Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/selp/
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_354

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SELP gene:
    Search GeneIP for patents involving SELP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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