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Aliases for SELP Gene

Aliases for SELP Gene

  • Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) 2 3
  • Platelet Activation Dependent Granule-External Membrane Protein 3 4
  • Leukocyte-Endothelial Cell Adhesion Molecule 3 3 4
  • CD62 Antigen-Like Family Member P 3 4
  • Granule Membrane Protein 140 3 4
  • GMP-140 3 4
  • LECAM3 3 4
  • PADGEM 3 4
  • GRMP 3 4
  • Selectin P (Granule Membrane Protein 140kD, Antigen CD62) 2
  • Platelet Alpha-Granule Membrane Protein 3
  • Granulocyte Membrane Protein 3
  • Antigen CD62) 6
  • CD62P Antigen 4
  • P-Selectin 3
  • GMP140 3
  • CD62P 3
  • CD62 3
  • PSEL 3
  • GMRP 4

External Ids for SELP Gene

Previous Symbols for SELP Gene

  • GRMP

Summaries for SELP Gene

Entrez Gene Summary for SELP Gene

  • This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]

GeneCards Summary for SELP Gene

SELP (Selectin P (Granule Membrane Protein 140kDa, Antigen CD62)) is a Protein Coding gene. Diseases associated with SELP include arteriosclerosis obliterans and intermittent claudication. Among its related pathways are Hemostasis and amb2 Integrin signaling. GO annotations related to this gene include heparin binding and glycoprotein binding. An important paralog of this gene is CSMD3.

UniProtKB/Swiss-Prot for SELP Gene

  • Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.

Tocris Summary for SELP Gene

  • Cellular adhesion molecules (CAMs) are a large family of proteins that attach the cytoskeleton and intracellular signalling cascades with the extracellular environment. CAMs have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture, and their dysregulation is common in cancer. The selectins are Ca2+-dependent CAMs that bind fucosylated carbohydrates (e.g. mucins). There are three types of selectins, E-selectin (endothelial), L-selectin (leukocyte) and P-selectin (platelet).

Gene Wiki entry for SELP Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELP Gene

Genomics for SELP Gene

Genomic Location for SELP Gene

Start:
169,588,849 bp from pter
End:
169,630,193 bp from pter
Size:
41,345 bases
Orientation:
Minus strand

Genomic View for SELP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SELP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELP Gene

Regulatory Elements for SELP Gene

Proteins for SELP Gene

  • Protein details for SELP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16109-LYAM3_HUMAN
    Recommended name:
    P-selectin
    Protein Accession:
    P16109
    Secondary Accessions:
    • Q5R344
    • Q8IVD1

    Protein attributes for SELP Gene

    Size:
    830 amino acids
    Molecular mass:
    90834 Da
    Quaternary structure:
    • Interacts with SNX17. Interacts with PSGL1/SEPL and PODXL2 and mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine sulfation on PSGL1.

    Three dimensional structures from OCA and Proteopedia for SELP Gene

neXtProt entry for SELP Gene

Proteomics data for SELP Gene at MOPED

Post-translational modifications for SELP Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn54, Asn98, Asn180, Asn212, Asn219, Asn411, Asn460, Asn518, Asn665, Asn716, Asn723, and Asn741

Other Protein References for SELP Gene

No data available for DME Specific Peptides for SELP Gene

Domains for SELP Gene

Gene Families for SELP Gene

HGNC:
  • CD :CD molecules

UniProtKB/Swiss-Prot:

LYAM3_HUMAN
Domain:
  • Contains 1 C-type lectin domain.:
    • P16109
  • Contains 1 EGF-like domain.:
    • P16109
  • Contains 9 Sushi (CCP/SCR) domains.:
    • P16109
Family:
  • Belongs to the selectin/LECAM family.:
    • P16109
genes like me logo Genes that share domains with SELP: view

Function for SELP Gene

Molecular function for SELP Gene

GENATLAS Biochemistry: P selectin,leukocyte adhesion molecule,granule membrane protein (platelet,endothelium),induced by thrombin,histamine,peroxides from platelet alpha granule,high expressed in atherosclerotic plaques
UniProtKB/Swiss-Prot Function: Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.

Gene Ontology (GO) - Molecular Function for SELP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IMP 16514062
GO:0001948 glycoprotein binding IEA --
GO:0005515 protein binding IPI 11237770
GO:0008201 heparin binding IDA 7680663
GO:0030246 carbohydrate binding --
genes like me logo Genes that share ontologies with SELP: view
genes like me logo Genes that share phenotypes with SELP: view

Animal Models for SELP Gene

MGI Knock Outs for SELP:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SELP Gene

Localization for SELP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELP Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SELP Gene COMPARTMENTS Subcellular localization image for SELP gene
Compartment Confidence
extracellular 4
nucleus 4
plasma membrane 4
cytosol 3
cytoskeleton 2
lysosome 2
endosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SELP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 9290466
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with SELP: view

Pathways for SELP Gene

genes like me logo Genes that share pathways with SELP: view

Gene Ontology (GO) - Biological Process for SELP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0002687 positive regulation of leukocyte migration IEA --
GO:0006954 inflammatory response IEA --
GO:0007155 cell adhesion TAS 2466574
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA --
genes like me logo Genes that share ontologies with SELP: view

Compounds for SELP Gene

(5) Tocris Compounds for SELP Gene

Compound Action Cas Number
Ac2-26 Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation [151988-33-9]
Echistatin, alpha1 isoform alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor [154303-05-6]
Heparin sodium salt Anticoagulant [9041-08-1]
RGDS peptide Integrin binding sequence; inhibits integrin receptor function [91037-65-9]
Thiolutin Bacterial RNA polymerase inhibitor [87-11-6]

(3) HMDB Compounds for SELP Gene

Compound Synonyms Cas Number PubMed IDs
3-O-Sulfogalactosylceramide (d18:1/24:0)
  • Sulfatide (d18:1/24:0)
151122-71-3
Clopidogrel
  • (+)-(S)-Clopidogrel
113665-84-2
Sialyl-Lewis X
  • 3'-Sialyl-Lewis X
98603-84-0

(4) Drugbank Compounds for SELP Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Dalteparin
  • Daltepariininatrium
9041-08-1 target inhibitor
Heparin
  • Alpha-Heparin
9005-49-6 target inhibitor
Nadroparin
9041-08-1 target inhibitor
O-Sialic Acid
target

(138) Novoseek inferred chemical compound relationships for SELP Gene

Compound -log(P) Hits PubMed IDs
adp 86.4 158
slex 84.1 62
fibrinogen 83.2 210
clopidogrel 79.2 82
aspirin 74.7 111
genes like me logo Genes that share compounds with SELP: view

Transcripts for SELP Gene

Unigene Clusters for SELP Gene

Selectin P (granule membrane protein 140kDa, antigen CD62):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SELP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c · 17d
SP1: - -
SP2: - -
SP3: - -
SP4: - - -
SP5:

Relevant External Links for SELP Gene

GeneLoc Exon Structure for
SELP
ECgene alternative splicing isoforms for
SELP

Expression for SELP Gene

mRNA expression in normal human tissues for SELP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SELP Gene

SOURCE GeneReport for Unigene cluster for SELP Gene Hs.73800

mRNA Expression by UniProt/SwissProt for SELP Gene

P16109-LYAM3_HUMAN
Tissue specificity: Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface
genes like me logo Genes that share expressions with SELP: view

Orthologs for SELP Gene

This gene was present in the common ancestor of animals.

Orthologs for SELP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SELP 36
  • 98.8 (n)
  • 98.07 (a)
SELP 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SELP 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SELP 36
  • 83.86 (n)
  • 77.23 (a)
SELP 37
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Selp 36
  • 75.23 (n)
  • 68.92 (a)
Selp 16
Selp 37
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SELP 37
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 42 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Selp 36
  • 75.87 (n)
  • 71.7 (a)
chicken
(Gallus gallus)
Aves SELP 36
  • 53.55 (n)
  • 43.17 (a)
SELP 37
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SELP 37
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia selp 36
  • 53.91 (n)
  • 46.47 (a)
zebrafish
(Danio rerio)
Actinopterygii selp 36
  • 50.39 (n)
  • 42.13 (a)
selp 37
  • 37 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta hig 37
  • 14 (a)
OneToMany
fw 38
  • 25 (a)
worm
(Caenorhabditis elegans)
Secernentea lev-9 37
  • 19 (a)
OneToMany
T07H6.5 38
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 10 (a)
ManyToMany
-- 37
  • 12 (a)
ManyToMany
-- 37
  • 11 (a)
ManyToMany
-- 37
  • 14 (a)
ManyToMany
CSA.10017 37
  • 26 (a)
ManyToMany
CSA.10029 37
  • 9 (a)
ManyToMany
Species with no ortholog for SELP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SELP Gene

ENSEMBL:
Gene Tree for SELP (if available)
TreeFam:
Gene Tree for SELP (if available)

Paralogs for SELP Gene

Paralogs for SELP Gene

Selected SIMAP similar genes for SELP Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with SELP: view

Variants for SELP Gene

Sequence variations from dbSNP and Humsavar for SELP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs6124 - 169,612,276(-) TGGAC(C/T)GGAAG reference, missense
rs6125 - 169,613,079(-) AACAC(A/G)TGCTC missense, reference
rs6126 -- 169,597,118(-) GACAC(C/T)CGTGG synonymous-codon, reference
rs6127 - 169,597,075(-) CTTGT(A/G)ACAAC missense, reference
rs6128 -- 169,593,666(-) TCTAC(A/G)ATAGG synonymous-codon, reference, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SELP Gene

Variant ID Type Subtype PubMed ID
esv22143 CNV Gain+Loss 19812545
nsv872534 CNV Loss 21882294
nsv872538 CNV Gain 21882294
esv2658365 CNV Deletion 23128226
nsv517483 CNV Loss 19592680
esv2516985 CNV Deletion 19546169

Relevant External Links for SELP Gene

HapMap Linkage Disequilibrium report
SELP
Human Gene Mutation Database (HGMD)
SELP

Disorders for SELP Gene

(1) OMIM Diseases for SELP Gene (173610)

UniProtKB/Swiss-Prot

LYAM3_HUMAN
  • Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. {ECO:0000269 PubMed:14681304}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(98) Novoseek inferred disease relationships for SELP Gene

Disease -log(P) Hits PubMed IDs
thrombosis 74.4 59
inflammation 73.7 108
gray platelet syndrome 72.7 1
platelet dysfunction 71.5 5
atherosclerosis 65.5 67

Relevant External Links for SELP

Genetic Association Database (GAD)
SELP
Human Genome Epidemiology (HuGE) Navigator
SELP
genes like me logo Genes that share disorders with SELP: view

Publications for SELP Gene

  1. P-selectin is acylated with palmitic acid and stearic acid at cysteine 766 through a thioester linkage. (PMID: 7684381) Fujimoto T. … McEver R.P. (J. Biol. Chem. 1993) 3 4 23
  2. The P-selectin gene is highly polymorphic: reduced frequency of the Pro715 allele carriers in patients with myocardial infarction. (PMID: 9668170) Herrmann S.M. … Cambien F. (Hum. Mol. Genet. 1998) 3 4 23
  3. Association between P-selectin gene polymorphisms and soluble P-selectin levels and their relation to coronary artery disease. (PMID: 11597943) Barbaux S.C. … Tiret L. (Arterioscler. Thromb. Vasc. Biol. 2001) 3 23 49
  4. Specific haplotypes of the P-selectin gene are associated with myocardial infarction. (PMID: 12165563) Tregouet D.A. … Cambien F. (Hum. Mol. Genet. 2002) 3 23 49
  5. Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen. (PMID: 12871600) Adams G.T. … Kutlar A. (BMC Med. Genet. 2003) 3 23 49

Products for SELP Gene

Sources for SELP Gene

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