Aliases for SELP Gene
- Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) 2 3
- Platelet Activation Dependent Granule-External Membrane Protein 3 4
- Leukocyte-Endothelial Cell Adhesion Molecule 3 3 4
- CD62 Antigen-Like Family Member P 3 4
- Granule Membrane Protein 140 3 4
- GMP-140 3 4
- LECAM3 3 4
- PADGEM 3 4
- GRMP 3 4
- Selectin P (Granule Membrane Protein 140kD, Antigen CD62) 2
- Platelet Alpha-Granule Membrane Protein 3
External Ids for SELP Gene
Previous Symbols for SELP Gene
This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]
GeneCards Summary for SELP Gene
SELP (Selectin P (Granule Membrane Protein 140kDa, Antigen CD62)) is a Protein Coding gene. Diseases associated with SELP include arteriosclerosis obliterans and intermittent claudication. Among its related pathways are Hemostasis and amb2 Integrin signaling. GO annotations related to this gene include heparin binding and glycoprotein binding. An important paralog of this gene is CSMD3.
UniProtKB/Swiss-Prot for SELP Gene
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.
Cellular adhesion molecules (CAMs) are a large family of proteins that attach the cytoskeleton and intracellular signalling cascades with the extracellular environment. CAMs have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture, and their dysregulation is common in cancer. The selectins are Ca2+-dependent CAMs that bind fucosylated carbohydrates (e.g. mucins). There are three types of selectins, E-selectin (endothelial), L-selectin (leukocyte) and P-selectin (platelet).