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Aliases for SELP Gene

Aliases for SELP Gene

  • Selectin P 2 3 5
  • Platelet Activation Dependent Granule-External Membrane Protein 3 4
  • Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) 2 3
  • Leukocyte-Endothelial Cell Adhesion Molecule 3 3 4
  • CD62 Antigen-Like Family Member P 3 4
  • Granule Membrane Protein 140kDa 2 3
  • Granule Membrane Protein 140 3 4
  • GMP-140 3 4
  • LECAM3 3 4
  • PADGEM 3 4
  • GRMP 3 4
  • Selectin P (Granule Membrane Protein 140kD, Antigen CD62) 2
  • Platelet Alpha-Granule Membrane Protein 3
  • Granulocyte Membrane Protein 3
  • CD62P Antigen 4
  • Antigen CD62 2
  • P-Selectin 3
  • GMP140 3
  • CD62P 3
  • CD62 3
  • PSEL 3
  • GMRP 4

External Ids for SELP Gene

Previous HGNC Symbols for SELP Gene

  • GRMP

Previous GeneCards Identifiers for SELP Gene

  • GC01M167186
  • GC01M165208
  • GC01M166254
  • GC01M166745
  • GC01M166290
  • GC01M167824
  • GC01M140780

Summaries for SELP Gene

Entrez Gene Summary for SELP Gene

  • This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]

GeneCards Summary for SELP Gene

SELP (Selectin P) is a Protein Coding gene. Diseases associated with SELP include Atopy and Arteriosclerosis Obliterans. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Spinal Cord Injury. GO annotations related to this gene include carbohydrate binding and calcium-dependent protein binding. An important paralog of this gene is SELE.

UniProtKB/Swiss-Prot for SELP Gene

  • Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.

Tocris Summary for SELP Gene

  • Cell adhesion molecules (CAMs) are a large family of transmembrane proteins that are involved in the binding of a cell to another cell or to the extracellular matrix. They have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture.

Gene Wiki entry for SELP Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELP Gene

Genomics for SELP Gene

Regulatory Elements for SELP Gene

Enhancers for SELP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G169688 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -66.8 -66804 17.4 YBX3 PKNOX1 RAD21 GATA2 FOS RELB ETV6 IKZF2 CBFB JUNB METTL18 C1orf112 SELP F5 DPT SELL SCYL3 KIFAP3 ENSG00000230704 METTL11B
GH01G169600 1.2 ENCODE dbSUPER 11.4 +28.6 28553 1.6 ELF3 FOXA2 ARID4B DMAP1 RAD21 YY1 RARA GATA4 CREM THAP11 SELP C1orf112 METTL18 F5 SELL
GH01G169667 1.1 Ensembl ENCODE dbSUPER 11.6 -37.5 -37508 1.4 YBX3 MAFG ZNF316 ZNF512 NBN NFE2 IRF1 EMSY METTL18 SELP DPT SELL C1orf112
GH01G169604 1 Ensembl ENCODE dbSUPER 12.3 +25.2 25192 1.2 CTCF ZNF24 PRDM1 SELP SELE SELL F5
GH01G169676 1 Ensembl ENCODE dbSUPER 11.1 -46.0 -46008 0.4 GATA2 JUN FOS SELP METTL18 C1orf112 SELL
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SELP on UCSC Golden Path with GeneCards custom track

Genomic Location for SELP Gene

Chromosome:
1
Start:
169,588,849 bp from pter
End:
169,630,193 bp from pter
Size:
41,345 bases
Orientation:
Minus strand

Genomic View for SELP Gene

Genes around SELP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELP Gene

Proteins for SELP Gene

  • Protein details for SELP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16109-LYAM3_HUMAN
    Recommended name:
    P-selectin
    Protein Accession:
    P16109
    Secondary Accessions:
    • Q5R344
    • Q8IVD1

    Protein attributes for SELP Gene

    Size:
    830 amino acids
    Molecular mass:
    90834 Da
    Quaternary structure:
    • Interacts with SNX17. Interacts with PSGL1/SEPL and PODXL2 and mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine sulfation on PSGL1.

    Three dimensional structures from OCA and Proteopedia for SELP Gene

neXtProt entry for SELP Gene

Post-translational modifications for SELP Gene

  • Glycosylation at Asn54, isoforms=98, isoforms=180, isoforms=212, Asn219, isoforms=411, isoforms=460, isoforms=518, isoforms=665, isoforms=716, Asn723, and Asn741
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SELP Gene

Domains & Families for SELP Gene

Graphical View of Domain Structure for InterPro Entry

P16109

UniProtKB/Swiss-Prot:

LYAM3_HUMAN :
  • Belongs to the selectin/LECAM family.
Family:
  • Belongs to the selectin/LECAM family.
genes like me logo Genes that share domains with SELP: view

Function for SELP Gene

Molecular function for SELP Gene

GENATLAS Biochemistry:
P selectin,leukocyte adhesion molecule,granule membrane protein (platelet,endothelium),induced by thrombin,histamine,peroxides from platelet alpha granule,high expressed in atherosclerotic plaques
UniProtKB/Swiss-Prot Function:
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.

Gene Ontology (GO) - Molecular Function for SELP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IMP 16514062
GO:0001948 glycoprotein binding IEA --
GO:0005515 protein binding IPI 9129046
GO:0008201 heparin binding IDA 7680663
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with SELP: view
genes like me logo Genes that share phenotypes with SELP: view

Animal Models for SELP Gene

MGI Knock Outs for SELP:

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SELP Gene

Localization for SELP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELP Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELP gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 3
cytosol 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
lysosome 2
endosome 1

Gene Ontology (GO) - Cellular Components for SELP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 9290466
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1701178
GO:0009897 external side of plasma membrane IDA 16514062
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SELP: view

Pathways & Interactions for SELP Gene

genes like me logo Genes that share pathways with SELP: view

SIGNOR curated interactions for SELP Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SELP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0002687 positive regulation of leukocyte migration IEA --
GO:0006954 inflammatory response IEA --
GO:0007155 cell adhesion IEA,TAS 2466574
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA --
genes like me logo Genes that share ontologies with SELP: view

Drugs & Compounds for SELP Gene

(84) Drugs for SELP Gene - From: DrugBank, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist, Target, inhibitor 848,265
Nadroparin Approved Pharma Target, inhibitor 35
Clopidogrel Approved Nutra P2Y12 receptor antagonist 778
Dalteparin Approved Pharma Target, inhibitor 317
N-acetyl-alpha-neuraminic acid Experimental Pharma Target 0

(68) Additional Compounds for SELP Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-O-Sulfogalactosylceramide (d18:1/24:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • 3-O-Sulphogalactosylceramide
151122-71-3
Sialyl-Lewis X
  • 3'-Sialyl-Lewis X
  • 3'-Sialyl-Lewis-X tetrasaccharide
  • 3'-SLeX
  • a-NeuNAc-(2>3)-b-D-Gal-(1>4)(a-L-Fuc-[1>3])-D-GlcNAc
  • alpha-NeuNAc-(2>3)-beta-delta-Gal-(1>4)(a-L-Fuc-[1>3])-delta-GlcNAc
98603-84-0
Ac2-26
151988-33-9
Echistatin, alpha1 isoform
154303-05-6
Heparin sodium salt
9041-08-1

(5) Tocris Compounds for SELP Gene

Compound Action Cas Number
Ac2-26 Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation 151988-33-9
BIO 5192 Highly potent and selective inhibitor of integrin alpha4beta1 327613-57-0
Echistatin, alpha1 isoform alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor 154303-05-6
Heparin sodium salt Anticoagulant 9041-08-1
RGDS peptide Integrin binding sequence; inhibits integrin receptor function 91037-65-9
genes like me logo Genes that share compounds with SELP: view

Transcripts for SELP Gene

Unigene Clusters for SELP Gene

Selectin P (granule membrane protein 140kDa, antigen CD62):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SELP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c · 17d
SP1: - -
SP2: - -
SP3: - -
SP4: - - -
SP5:

Relevant External Links for SELP Gene

GeneLoc Exon Structure for
SELP
ECgene alternative splicing isoforms for
SELP

Expression for SELP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SELP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SELP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.7), Platelet (20.2), Serum (9.7), and Monocytes (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SELP Gene



NURSA nuclear receptor signaling pathways regulating expression of SELP Gene:

SELP

SOURCE GeneReport for Unigene cluster for SELP Gene:

Hs.73800

mRNA Expression by UniProt/SwissProt for SELP Gene:

P16109-LYAM3_HUMAN
Tissue specificity: Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.

Evidence on tissue expression from TISSUES for SELP Gene

  • Blood(4.8)
  • Heart(3.5)
  • Lung(2.7)
  • Intestine(2.5)
  • Muscle(2.4)
  • Bone marrow(2.2)
  • Kidney(2.2)
  • Lymph node(2.2)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with SELP: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SELP Gene

Orthologs for SELP Gene

This gene was present in the common ancestor of animals.

Orthologs for SELP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SELP 34 35
  • 98.8 (n)
dog
(Canis familiaris)
Mammalia SELP 34 35
  • 83.86 (n)
cow
(Bos Taurus)
Mammalia SELP 35
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Selp 34
  • 75.87 (n)
mouse
(Mus musculus)
Mammalia Selp 34 16 35
  • 75.23 (n)
oppossum
(Monodelphis domestica)
Mammalia SELP 35
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 42 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SELP 34 35
  • 53.55 (n)
lizard
(Anolis carolinensis)
Reptilia SELP 35
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia selp 34
  • 53.91 (n)
zebrafish
(Danio rerio)
Actinopterygii selp 34 35
  • 50.39 (n)
fruit fly
(Drosophila melanogaster)
Insecta fw 36
  • 25 (a)
hig 35
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T07H6.5 36
  • 27 (a)
lev-9 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10017 35
  • 26 (a)
ManyToMany
-- 35
  • 14 (a)
ManyToMany
-- 35
  • 12 (a)
ManyToMany
-- 35
  • 11 (a)
ManyToMany
-- 35
  • 10 (a)
ManyToMany
CSA.10029 35
  • 9 (a)
ManyToMany
Species where no ortholog for SELP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SELP Gene

ENSEMBL:
Gene Tree for SELP (if available)
TreeFam:
Gene Tree for SELP (if available)

Paralogs for SELP Gene

genes like me logo Genes that share paralogs with SELP: view

Variants for SELP Gene

Sequence variations from dbSNP and Humsavar for SELP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs730880284 Likely pathogenic 169,612,928(-) TTTAG(A/C/G)TATGT splice-donor-variant
rs6136 Benign 169,594,713(-) GGTCA(A/C)CTACC reference, missense
rs6133 other 169,596,108(-) CAGGG(C/G/T)TGCAA reference, missense
rs1000033133 -- 169,629,888(+) CACAA(A/G)GGTGT intron-variant
rs1000048231 -- 169,594,877(+) TCACA(A/G)CTGCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SELP Gene

Variant ID Type Subtype PubMed ID
esv22143 CNV gain+loss 19812545
esv2516985 CNV deletion 19546169
esv2658365 CNV deletion 23128226
esv2762197 CNV loss 21179565
esv3587886 CNV loss 21293372
nsv1078878 OTHER inversion 25765185
nsv472783 CNV novel sequence insertion 20440878
nsv517483 CNV loss 19592680
nsv548187 CNV loss 21841781

Variation tolerance for SELP Gene

Residual Variation Intolerance Score: 92.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.85; 79.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELP Gene

Human Gene Mutation Database (HGMD)
SELP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELP Gene

Disorders for SELP Gene

MalaCards: The human disease database

(61) MalaCards diseases for SELP Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
atopy
  • atopic hypersensitivity
arteriosclerosis obliterans
  • arteriosclerosis obliterans [ambiguous]
immune-complex glomerulonephritis
  • immune complex glomerulonephritis
peripheral vascular disease
  • arterial occlusive disease
intermittent claudication
  • charcot's syndrome
- elite association - COSMIC cancer census association via MalaCards
Search SELP in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LYAM3_HUMAN
  • Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. {ECO:0000269 PubMed:14681304}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for SELP

Genetic Association Database (GAD)
SELP
Human Genome Epidemiology (HuGE) Navigator
SELP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELP
genes like me logo Genes that share disorders with SELP: view

No data available for Genatlas for SELP Gene

Publications for SELP Gene

  1. SELP and SELPLG genetic variation is associated with cell surface measures of SELP and SELPLG: the Atherosclerosis Risk in Communities Carotid MRI Study. (PMID: 19395438) Volcik K.A. … Boerwinkle E. (Clin. Chem. 2009) 3 22 46 64
  2. Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins. (PMID: 18606703) Kerr S.C. … Rosen S.D. (J. Immunol. 2008) 3 4 22 64
  3. Soluble P-selectin, SELP polymorphisms, and atherosclerotic risk in European-American and African-African young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. (PMID: 18535285) Reiner A.P. … Gross M.D. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 22 46 64
  4. P-selectin polymorphisms' influences on P-selectin serum concentrations and on their familial correlation: the STANISLAS family study. (PMID: 18363816) Marteau J.B. … Visvikis-Siest S. (J. Thromb. Haemost. 2008) 3 22 46 64
  5. Clinical and genetic correlates of soluble P-selectin in the community. (PMID: 17944986) Lee D.S. … Benjamin E.J. (J. Thromb. Haemost. 2008) 3 22 46 64

Products for SELP Gene

Sources for SELP Gene

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