Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SELO Gene

Aliases for SELO Gene

  • Selenoprotein O 3 5
  • SelO 4

External Ids for SELO Gene

Previous GeneCards Identifiers for SELO Gene

  • GC22P048821
  • GC22P048941
  • GC22P050639

Summaries for SELO Gene

Entrez Gene Summary for SELO Gene

  • This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]

GeneCards Summary for SELO Gene

SELO (Selenoprotein O) is a Protein Coding gene. Among its related pathways are Selenium Pathway and Selenium Metabolism and Selenoproteins.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELO Gene

Genomics for SELO Gene

Regulatory Elements for SELO Gene

Enhancers for SELO Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SELO on UCSC Golden Path with GeneCards custom track

Promoters for SELO Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SELO on UCSC Golden Path with GeneCards custom track

Genomic Location for SELO Gene

Chromosome:
22
Start:
50,200,979 bp from pter
End:
50,217,616 bp from pter
Size:
16,638 bases
Orientation:
Plus strand

Genomic View for SELO Gene

Genes around SELO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELO Gene

Proteins for SELO Gene

  • Protein details for SELO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVL4-SELO_HUMAN
    Recommended name:
    Selenoprotein O
    Protein Accession:
    Q9BVL4
    Secondary Accessions:
    • Q2TAL2
    • Q5JZ81
    • Q8WUI0

    Protein attributes for SELO Gene

    Size:
    669 amino acids
    Molecular mass:
    73489 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH01099.3; Type=Erroneous termination; Positions=667; Note=Translated as Sec.; Evidence={ECO:0000305}; Sequence=AAH20510.1; Type=Erroneous termination; Positions=667; Note=Translated as Sec.; Evidence={ECO:0000305};

neXtProt entry for SELO Gene

Proteomics data for SELO Gene at MOPED

Post-translational modifications for SELO Gene

  • Ubiquitination at Lys 377 and Lys 621
  • Modification sites at PhosphoSitePlus

Other Protein References for SELO Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SELO Gene

Domains & Families for SELO Gene

Protein Domains for SELO Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SELO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BVL4

UniProtKB/Swiss-Prot:

SELO_HUMAN :
  • Belongs to the UPF0061 (SELO) family.
Family:
  • Belongs to the UPF0061 (SELO) family.
genes like me logo Genes that share domains with SELO: view

No data available for Gene Families for SELO Gene

Function for SELO Gene

genes like me logo Genes that share phenotypes with SELO: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SELO Gene

Localization for SELO Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SELO Gene COMPARTMENTS Subcellular localization image for SELO gene
Compartment Confidence
mitochondrion 3
cytosol 2
nucleus 2
extracellular 1
lysosome 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SELO Gene

Pathways & Interactions for SELO Gene

genes like me logo Genes that share pathways with SELO: view

Pathways by source for SELO Gene

2 BioSystems pathways for SELO Gene

Interacting Proteins for SELO Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000370288%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000225396%0d%0a9606.ENSP00000308022%0d%0a9606.ENSP00000357048%0d%0a
Selected Interacting proteins: ENSP00000370288 Q9BVL4-SELO_HUMAN for SELO Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SELO Gene

None

No data available for SIGNOR curated interactions for SELO Gene

Drugs & Compounds for SELO Gene

No Compound Related Data Available

Transcripts for SELO Gene

mRNA/cDNA for SELO Gene

Unigene Clusters for SELO Gene

Selenoprotein O:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SELO Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: - - - - - - - -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6: - - -
SP7:
SP8: -
SP9: - -
SP10:

Relevant External Links for SELO Gene

GeneLoc Exon Structure for
SELO

Expression for SELO Gene

mRNA expression in normal human tissues for SELO Gene

mRNA differential expression in normal tissues according to GTEx for SELO Gene

This gene is overexpressed in Liver (x4.6).

Protein differential expression in normal tissues from HIPED for SELO Gene

This gene is overexpressed in Adipocyte (10.6), Peripheral blood mononuclear cells (8.1), and Liver (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SELO Gene



SOURCE GeneReport for Unigene cluster for SELO Gene Hs.365405

genes like me logo Genes that share expression patterns with SELO: view

Protein tissue co-expression partners for SELO Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SELO Gene

Orthologs for SELO Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SELO Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SELO 35
  • 84.06 (n)
  • 83.07 (a)
SELO 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SELO 35
  • 85.36 (n)
  • 85.77 (a)
-- 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Selo 35
  • 80.09 (n)
  • 82.12 (a)
Selo 16
Selo 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SELO 35
  • 97.24 (n)
  • 96.97 (a)
-- 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Selo 35
  • 80.06 (n)
  • 82.57 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves SELO 35
  • 70.7 (n)
  • 74.03 (a)
SELO 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia selo 35
  • 63.85 (n)
  • 66.23 (a)
zebrafish
(Danio rerio)
Actinopterygii selo 35
  • 60.5 (n)
  • 59.74 (a)
wufd10b07 35
selo 36
  • 52 (a)
OneToMany
si:dkey-14d8.2 36
  • 51 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FMP40 36
  • 25 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G13030 35
  • 48.83 (n)
  • 45.27 (a)
soybean
(Glycine max)
eudicotyledons Gma.1585 35
barley
(Hordeum vulgare)
Liliopsida Hv.5200 35
rice
(Oryza sativa)
Liliopsida Os.9272 35
Os06g0320700 35
  • 51.05 (n)
  • 47.04 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToOne
Species with no ortholog for SELO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SELO Gene

ENSEMBL:
Gene Tree for SELO (if available)
TreeFam:
Gene Tree for SELO (if available)

Paralogs for SELO Gene

(1) SIMAP similar genes for SELO Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SELO: view

No data available for Paralogs for SELO Gene

Variants for SELO Gene

Sequence variations from dbSNP and Humsavar for SELO Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_059952 -
VAR_059953 -
VAR_059954 -
VAR_059955 -
rs7287911 -- 50,207,117(+) CAGTT(A/G)TCAGt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SELO Gene

Variant ID Type Subtype PubMed ID
nsv915495 CNV Loss 21882294
dgv5051n71 CNV Loss 21882294
dgv5054n71 CNV Loss 21882294
dgv781n67 CNV Gain 20364138
dgv5055n71 CNV Loss 21882294
nsv829333 CNV Gain 20364138
dgv5056n71 CNV Loss 21882294
dgv5057n71 CNV Loss 21882294
nsv914515 CNV Gain 21882294
nsv471223 CNV Loss 18288195

Variation tolerance for SELO Gene

Residual Variation Intolerance Score: 66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.12; 61.24% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SELO Gene

Disorders for SELO Gene

No disorders were found for SELO Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for SELO Gene

Publications for SELO Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Characterization of mammalian selenoprotein o: a redox-active mitochondrial protein. (PMID: 24751718) Han S.J. … Lee S.R. (PLoS ONE 2014) 3
  5. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3

Products for SELO Gene

Sources for SELO Gene

Content