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Aliases for SELO Gene

Aliases for SELO Gene

  • Selenoprotein O 3
  • SelO 4

External Ids for SELO Gene

Previous GeneCards Identifiers for SELO Gene

  • GC22P048821
  • GC22P048941
  • GC22P050639

Summaries for SELO Gene

Entrez Gene Summary for SELO Gene

  • This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]

GeneCards Summary for SELO Gene

SELO (Selenoprotein O) is a Protein Coding gene. Among its related pathways are Selenium Metabolism and Selenoproteins and Selenium Pathway.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELO Gene

Genomics for SELO Gene

Regulatory Elements for SELO Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SELO Gene

50,200,979 bp from pter
50,217,616 bp from pter
16,638 bases
Plus strand

Genomic View for SELO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SELO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELO Gene

Proteins for SELO Gene

  • Protein details for SELO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Selenoprotein O
    Protein Accession:
    Secondary Accessions:
    • Q2TAL2
    • Q5JZ81
    • Q8WUI0

    Protein attributes for SELO Gene

    669 amino acids
    Molecular mass:
    73489 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH01099.3; Type=Erroneous termination; Positions=667; Note=Translated as Sec.; Evidence={ECO:0000305}; Sequence=AAH20510.1; Type=Erroneous termination; Positions=667; Note=Translated as Sec.; Evidence={ECO:0000305};

neXtProt entry for SELO Gene

Proteomics data for SELO Gene at MOPED

Post-translational modifications for SELO Gene

  • Ubiquitination at Lys 377 and Lys 621
  • Modification sites at PhosphoSitePlus

Other Protein References for SELO Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SELO Gene

Domains & Families for SELO Gene

Protein Domains for SELO Gene


Suggested Antigen Peptide Sequences for SELO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0061 (SELO) family.
  • Belongs to the UPF0061 (SELO) family.
genes like me logo Genes that share domains with SELO: view

No data available for Gene Families for SELO Gene

Function for SELO Gene

Phenotypes for SELO Gene

genes like me logo Genes that share phenotypes with SELO: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SELO

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SELO Gene

Localization for SELO Gene

Subcellular locations from

Jensen Localization Image for SELO Gene COMPARTMENTS Subcellular localization image for SELO gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SELO Gene

Pathways & Interactions for SELO Gene

genes like me logo Genes that share pathways with SELO: view

Pathways by source for SELO Gene

2 BioSystems pathways for SELO Gene

Interacting Proteins for SELO Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: Q9BVL4-SELO_HUMAN ENSP00000370288 for SELO Gene via I2D STRING

Gene Ontology (GO) - Biological Process for SELO Gene


No data available for SIGNOR curated interactions for SELO Gene

Drugs & Compounds for SELO Gene

No Compound Related Data Available

Transcripts for SELO Gene

Unigene Clusters for SELO Gene

Selenoprotein O:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SELO

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELO Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: - - - - - - - -
SP2: - - -
SP3: - -
SP4: -
SP6: - - -
SP8: -
SP9: - -

Relevant External Links for SELO Gene

GeneLoc Exon Structure for

Expression for SELO Gene

mRNA expression in normal human tissues for SELO Gene

mRNA differential expression in normal tissues according to GTEx for SELO Gene

This gene is overexpressed in Liver (x4.6).

Protein differential expression in normal tissues from HIPED for SELO Gene

This gene is overexpressed in Adipocyte (10.6), Peripheral blood mononuclear cells (8.1), and Liver (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SELO Gene

SOURCE GeneReport for Unigene cluster for SELO Gene Hs.365405

genes like me logo Genes that share expression patterns with SELO: view

Protein tissue co-expression partners for SELO Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SELO Gene

Orthologs for SELO Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SELO Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SELO 35
  • 84.06 (n)
  • 83.07 (a)
  • 80 (a)
(Canis familiaris)
Mammalia SELO 35
  • 85.36 (n)
  • 85.77 (a)
-- 36
  • 81 (a)
(Mus musculus)
Mammalia Selo 35
  • 80.09 (n)
  • 82.12 (a)
1300018J18Rik 16
Selo 36
  • 80 (a)
(Pan troglodytes)
Mammalia SELO 35
  • 97.24 (n)
  • 96.97 (a)
-- 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Selo 35
  • 80.06 (n)
  • 82.57 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
(Gallus gallus)
Aves SELO 35
  • 70.7 (n)
  • 74.03 (a)
  • 72 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia selo 35
  • 63.85 (n)
  • 66.23 (a)
(Danio rerio)
Actinopterygii selo 35
  • 60.5 (n)
  • 59.74 (a)
wufd10b07 35
selo 36
  • 52 (a)
si:dkey-14d8.2 36
  • 51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FMP40 36
  • 25 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G13030 35
  • 48.83 (n)
  • 45.27 (a)
(Glycine max)
eudicotyledons Gma.1585 35
(Hordeum vulgare)
Liliopsida Hv.5200 35
(Oryza sativa)
Liliopsida Os.9272 35
Os06g0320700 35
  • 51.05 (n)
  • 47.04 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
Species with no ortholog for SELO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SELO Gene

Gene Tree for SELO (if available)
Gene Tree for SELO (if available)

Paralogs for SELO Gene

(1) SIMAP similar genes for SELO Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SELO: view

No data available for Paralogs for SELO Gene

Variants for SELO Gene

Sequence variations from dbSNP and Humsavar for SELO Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs909687 -- 50,215,466(+) GGCAT(C/G)CGTGC intron-variant
rs2013430 -- 50,214,670(+) tgagg(C/T)aggag intron-variant
rs2013437 -- 50,214,437(+) CAACA(C/T)GGTGA intron-variant
rs2038049 -- 50,216,459(+) GCAGA(C/G)TGGTC intron-variant
rs2272847 -- 50,207,773(+) GGGGG(A/G)CAGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SELO Gene

Variant ID Type Subtype PubMed ID
nsv915495 CNV Loss 21882294
dgv5051n71 CNV Loss 21882294
dgv5054n71 CNV Loss 21882294
dgv781n67 CNV Gain 20364138
dgv5055n71 CNV Loss 21882294
nsv829333 CNV Gain 20364138
dgv5056n71 CNV Loss 21882294
dgv5057n71 CNV Loss 21882294
nsv914515 CNV Gain 21882294
nsv471223 CNV Loss 18288195

Variation tolerance for SELO Gene

Residual Variation Intolerance Score: 65.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.12; 61.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELO Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELO Gene

Disorders for SELO Gene

genes like me logo Genes that share disorders with SELO: view

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for SELO Gene

Publications for SELO Gene

  1. Selenoproteins and maternal nutrition. (PMID: 18790070) Pappas A.C. … Zervas G. (Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 2008) 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 67
  4. Characterization of mammalian selenoprotein o: a redox-active mitochondrial protein. (PMID: 24751718) Han S.J. … Lee S.R. (PLoS ONE 2014) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for SELO Gene

Sources for SELO Gene

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