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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SELO Gene

protein-coding GIFtS: 41
GCID: GC22P050639

SELO

Explore 3 diseases affiliated with
SELO via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Selenoprotein O²
SelO³

External Ids:	Entrez Gene: 83642²	Ensembl: ENSG00000073169⁷	OMIM: 607917⁵	UniProtKB: Q9BVL4³

Export aliases for SELO gene to outside databases

Previous GC identifers: GC22P048821 GC22P048941

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SELO:

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine

is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a

common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec

codon rather than as a stop signal. (provided by RefSeq, Jul 2008)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011526.7

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SELO gene promoter:
Tal-1 HSF1 (long) Nkx5-1 E47 Arnt c-Myb HSF1short aMEF-2 MRF-2 TGIF
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for SELO

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SELO

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.33 Ensembl cytogenetic band: 22q13.33

SELO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SELO gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P050639: view genomic region (about GC identifiers)

Start:	50,639,408 bp from pter	End:	50,656,045 bp from pter
Size:	16,638 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SELO_HUMAN, Q9BVL4 (See protein sequence)

Recommended Name: Selenoprotein O

Size: 669 amino acids; 73489 Da

Sequence caution: Sequence=AAH01099.3; Type=Erroneous termination; Positions=667; Note=Translated as Sec;

Sequence=AAH20510.1; Type=Erroneous termination; Positions=667; Note=Translated as Sec;

Secondary accessions: Q2TAL2 Q5JZ81 Q8WUI0

Explore the universe of human proteins at neXtProt for SELO: NX_Q9BVL4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BVL4

SELO Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_113642.1

ENSEMBL proteins:

ENSP00000370288

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SELO for domains About GeneDecksing

1 InterPro domain/family:

IPR003846 UPF0061

Graphical View of Domain Structure for InterPro Entry Q9BVL4

ProtoNet protein and cluster: Q9BVL4

1 Blocks protein family: IPB003846 Protein of unknown function UPF0061

UniProtKB/Swiss-Prot: SELO_HUMAN, Q9BVL4

Similarity: Belongs to the UPF0061 (SELO) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SELO
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate SELO:
		hsa-miR-1324 hsa-miR-483-5p hsa-miR-490-5p
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

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1 GenomeRNAi human phenotype for SELO:

Decreased circadian period len

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Selenium Metabolism and Selenoproteins

Selenium Metabolism and Selenoproteins

1.00

Selenium Pathway

Selenium Pathway

1.00

2 BioSystems Pathways for SELO

	Selenium Metabolism and Selenoproteins
	Selenium Pathway

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SELO

5/20 Interacting proteins for SELO (Q9BVL4³) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UFD1L	Q92890³	I2D: score=6
ADI1	Q9BV57³	I2D: score=5
GRPEL1	Q9HAV7³	I2D: score=5
COPA	P53621³	I2D: score=4
MARCH6	O60337³	I2D: score=3

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SELO
Search CenterWatch for drugs/clinical trials and news about SELO

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SELO gene:

NM_031454.1

Unigene Cluster for SELO:

Selenoprotein O

Hs.365405 [show with all ESTs]

Unigene Representative Sequence: BC110866

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000380903(uc021wry.1 uc010hap.3) ENST00000492092(uc003bjy.3)

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		hsa-miR-1324 hsa-miR-483-5p hsa-miR-490-5p
		Browse SwitchGear 3'UTR luciferase reporter plasmids

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Additional cDNA sequence:

AF274946.1 AY324823.1 BC001099.2 BC020510.1 BC032384.1 BC051758.1 BC110866.1 CR456464.1

12 DOTS entries:

DT.101982657 DT.408689 DT.97844290 DT.100795298 DT.86838431 DT.120652245 DT.100653327 DT.100765400

DT.97822475 DT.100775402 DT.40200037 DT.92027796

24/137 AceView cDNA sequences (see all 137):

F31473 NM_031454 BI821344 AA250849 BM743224 CR611149 AW006853 BQ675785

CR615532 AI857861 AA828383 AW085907 BC032384 CR456464 BQ644294 BC020510

BG764573 BC001099 AI190634 AF274946 BM740855 AY324823 BM824246 BQ188392

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SELO (see all 10) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	·	2d	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	·	5c	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10	^	11a	·	11b	^	12	^	13a	·	13b
SP1:					-		-		-		-										-		-												-		-
SP2:																					-														-		-
SP3:																																			-		-
SP4:																																			-
SP5:

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SELO expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGGCAGAGA

About this image
See SELO Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SELO

SOURCE GeneReport for Unigene cluster: Hs.365405

SABiosciences Custom PCR Arrays for SELO

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for SELO gene from 7/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	1300018J18Rik^{1 , 5}	RIKEN cDNA 1300018J18 gene^{1, 5}	80.44(n)¹ 82.2(a)¹		15 (44.60 cM)⁵ 223776¹ NM_027905.2¹ NP_082181.2¹ 89089084⁵
chicken (Gallus gallus)	Aves	SELO¹	selenoprotein O	71.3(n) 74.47(a)		417745 NM_001115017.1 NP_001108489.1
lizard (Anolis carolinensis)	Reptilia	--	--	64(a)	1 ↔ 1	5(64007391-64018564)
zebrafish (Danio rerio)	Actinopterygii	wufd10b07²	Transcribed sequence with weak similarity to protein pirS65241 (S. cerevisiae) S65241 hypothetical protein YPL222w - yeast (Saccharomyces cerevisiae) less	77.36(n)		57055351
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G13030¹	hypothetical protein	49.96(n) 47.58(a)		831143 NM_121306.4 NP_196807.2
rice (Oryza sativa)	Liliopsida	Os.9272²	Oryza sativa (japonica cultivar-group) cDNA cloneJ013145E07, full insert sequence less	73.42(n)		AK072187.1
E. coli (Escherichia coli)	Gamma proteobacteria	ydiU⁶	conserved protein, UPF0061 family	42(a)	1 ↔ 1	Chromosome(1787832-1789268)

ENSEMBL Gene Tree for SELO (if available)
TreeFam Gene Tree for SELO (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73893138^1,2	C,	--	50638612(+)	`AGAAGC/GTTCTG`	1	--	us2k¹		3		WA EA	240
rs151311757^1,2		--	50638811(+)	`ACACAA/GACCCC`	1	--	us2k¹		0	--	--	--	--
rs141324735^1,2		--	50638824(+)	`ATTCC-/TCCCCC`	1	--	us2k¹		0	--	--	--	--
rs114153455^1,2		--	50638864(+)	`ACCCCG/AGTGCC`	1	--	us2k¹		1		WA	118
rs1009610^1,2	C,H,	--	50638953(+)	`CACAGG/ATCCAA`	1	--	us2k¹		8		MN NA WA CSA EA	549
rs28668373^1,2	C,	--	50639059(+)	`GAACCG/TCGGCG`	1	--	us2k¹		4		NA WA EA	360
rs140544546^1,2		--	50639250(+)	`CAGCGC/GGCGCC`	1	--	us2k¹		0	--	--	--	--
rs145912868^1,2		--	50639320(+)	`ACGGAA/CGAGGC`	1	--	us2k¹		0	--	--	--	--
rs200613515^1,2		--	50639360(+)	`CCCCT-/CCCCCC`	1	--	us2k¹		0	--	--	--	--
rs7293065^1,2	C,	--	50639367(+)	`CCCCCA/CCCCGC`	1	--	us2k¹		2		NA	122

HapMap Linkage Disequilibrium report for SELO (50639408 - 50656045 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SELO: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SELO

DNA2.0 Custom Variant and Variant Library Synthesis for SELO

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SELO for disorders           About GeneDecksing

OMIM gene information: 607917    OMIM disorders: --

3 diseases for SELO:    About MalaCards

toxic shock syndrome staphyloenterotoxemia mastitis

3 diseases from the University of Copenhagen DISEASES database for SELO:

Toxic shock syndrome Staphyloenterotoxemia Mastitis

Export disorders for SELO gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SELO gene integrated from 9 sources:
(articles sorted by number of sources associating them with SELO)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Characterization of mammalian selenoproteomes. (PubMed id 12775843)^{1, 2} Kryukov G.V.... Gladyshev V.N. (2003)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)¹ Collins J.E.... Dunham I. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Selenoproteins and maternal nutrition. (PubMed id 18790070)⁹ Pappas A.C....Zervas G. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 83642

AceView: SELO

Ensembl:ENSG00000073169

euGenes: HUgn83642

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for SELO gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SELO gene:
Search GeneIP for patents involving SELO

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SELO
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SELO
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SELO
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SELO
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SELO

	GenScript Custom Purified and Recombinant Proteins Services for SELO		GenScript cDNA clones with any tag delivered in your preferred vector for SELO
	GenScript Custom Assay Services for SELO		GenScript Custom Superior Antibodies Services for SELO
	GenScript Custom overexpressing Cell Line Services for SELO		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELO

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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SELO Gene

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for SELO gene

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for SELO gene

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for SELO gene

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for SELO gene

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for SELO gene

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for SELO gene

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for SELO gene

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