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Aliases for SELO Gene

Aliases for SELO Gene

  • Selenoprotein O 3
  • SelO 4

External Ids for SELO Gene

Previous GeneCards Identifiers for SELO Gene

  • GC22P048821
  • GC22P048941
  • GC22P050639

Summaries for SELO Gene

Entrez Gene Summary for SELO Gene

  • This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]

GeneCards Summary for SELO Gene

SELO (Selenoprotein O) is a Protein Coding gene. Diseases associated with SELO include staphyloenterotoxemia. Among its related pathways are Selenium Metabolism and Selenoproteins and Selenium Pathway.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELO Gene

Genomics for SELO Gene

Regulatory Elements for SELO Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SELO Gene

50,200,979 bp from pter
50,217,616 bp from pter
16,638 bases
Plus strand

Genomic View for SELO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SELO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELO Gene

Proteins for SELO Gene

  • Protein details for SELO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Selenoprotein O
    Protein Accession:
    Secondary Accessions:
    • Q2TAL2
    • Q5JZ81
    • Q8WUI0

    Protein attributes for SELO Gene

    669 amino acids
    Molecular mass:
    73489 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH01099.3; Type=Erroneous termination; Positions=667; Note=Translated as Sec.; Evidence={ECO:0000305}; Sequence=AAH20510.1; Type=Erroneous termination; Positions=667; Note=Translated as Sec.; Evidence={ECO:0000305};

neXtProt entry for SELO Gene

Proteomics data for SELO Gene at MOPED

Post-translational modifications for SELO Gene

  • Ubiquitination at Lys377 and Lys621
  • Modification sites at PhosphoSitePlus

Other Protein References for SELO Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SELO Gene

Domains for SELO Gene

Protein Domains for SELO Gene


Suggested Antigen Peptide Sequences for SELO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0061 (SELO) family.
  • Belongs to the UPF0061 (SELO) family.
genes like me logo Genes that share domains with SELO: view

No data available for Gene Families for SELO Gene

Function for SELO Gene

Phenotypes for SELO Gene

GenomeRNAi human phenotypes for SELO:
genes like me logo Genes that share phenotypes with SELO: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SELO

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SELO Gene

Localization for SELO Gene

Subcellular locations from

Jensen Localization Image for SELO Gene COMPARTMENTS Subcellular localization image for SELO gene
Compartment Confidence
mitochondrion 3
cytosol 2
extracellular 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SELO Gene

Pathways for SELO Gene

genes like me logo Genes that share pathways with SELO: view

Pathways by source for SELO Gene

2 BioSystems pathways for SELO Gene

Interacting Proteins for SELO Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000370288 Q9BVL4-SELO_HUMAN for SELO Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SELO Gene


Transcripts for SELO Gene

Unigene Clusters for SELO Gene

Selenoprotein O:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SELO

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELO Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: - - - - - - - -
SP2: - - -
SP3: - -
SP4: -
SP6: - - -
SP8: -
SP9: - -

Relevant External Links for SELO Gene

GeneLoc Exon Structure for

Expression for SELO Gene

mRNA expression in normal human tissues for SELO Gene

mRNA differential expression in normal tissues according to GTEx for SELO Gene

This gene is overexpressed in Liver (4.6).

Protein differential expression in normal tissues for SELO Gene

This gene is overexpressed in Adipocyte (10.6), Peripheral blood mononuclear cells (8.1), and Liver (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SELO Gene

SOURCE GeneReport for Unigene cluster for SELO Gene Hs.365405

genes like me logo Genes that share expressions with SELO: view

Expression partners for SELO Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SELO Gene

Orthologs for SELO Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SELO Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SELO 35
  • 84.06 (n)
  • 83.07 (a)
  • 80 (a)
(Canis familiaris)
Mammalia SELO 35
  • 85.36 (n)
  • 85.77 (a)
-- 36
  • 81 (a)
(Mus musculus)
Mammalia Selo 35
  • 80.09 (n)
  • 82.12 (a)
1300018J18Rik 16
Selo 36
  • 80 (a)
(Pan troglodytes)
Mammalia SELO 35
  • 97.24 (n)
  • 96.97 (a)
-- 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Selo 35
  • 80.06 (n)
  • 82.57 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
(Gallus gallus)
Aves SELO 35
  • 70.7 (n)
  • 74.03 (a)
  • 72 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia selo 35
  • 63.85 (n)
  • 66.23 (a)
(Danio rerio)
Actinopterygii selo 35
  • 60.5 (n)
  • 59.74 (a)
wufd10b07 35
selo 36
  • 52 (a)
si:dkey-14d8.2 36
  • 51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FMP40 36
  • 25 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G13030 35
  • 48.83 (n)
  • 45.27 (a)
(Glycine max)
eudicotyledons Gma.1585 35
(Hordeum vulgare)
Liliopsida Hv.5200 35
(Oryza sativa)
Liliopsida Os.9272 35
Os06g0320700 35
  • 51.05 (n)
  • 47.04 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
Species with no ortholog for SELO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SELO Gene

Gene Tree for SELO (if available)
Gene Tree for SELO (if available)

Paralogs for SELO Gene

(1) SIMAP similar genes for SELO Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SELO: view

No data available for Paralogs for SELO Gene

Variants for SELO Gene

Sequence variations from dbSNP and Humsavar for SELO Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs56255915 -- 50,215,647(+) GGGGG(-/GG)TCTGT intron-variant
rs56372991 -- 50,210,844(+) GGCCT(C/T)GTGCA reference, synonymous-codon
rs56850037 -- 50,211,442(+) GAAGG(A/T)GCTGA intron-variant
rs58608683 -- 50,214,292(+) GTGAG(C/G)ACCTT intron-variant
rs58610841 -- 50,206,892(+) CTTCT(-/G)GGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SELO Gene

Variant ID Type Subtype PubMed ID
nsv915495 CNV Loss 21882294
dgv5051n71 CNV Loss 21882294
dgv5054n71 CNV Loss 21882294
dgv781n67 CNV Gain 20364138
dgv5055n71 CNV Loss 21882294
nsv829333 CNV Gain 20364138
dgv5056n71 CNV Loss 21882294
dgv5057n71 CNV Loss 21882294
nsv914515 CNV Gain 21882294
nsv471223 CNV Loss 18288195

Relevant External Links for SELO Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELO Gene

Disorders for SELO Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SELO Gene in MalaCards »

(1) Disease for SELO Gene

(3) University of Copenhagen DISEASES for SELO Gene

genes like me logo Genes that share disorders with SELO: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for SELO Gene

Publications for SELO Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  2. Characterization of mammalian selenoproteomes. (PMID: 12775843) Kryukov G.V. … Gladyshev V.N. (Science 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3

Products for SELO Gene

Sources for SELO Gene

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