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Aliases for SELO Gene

Aliases for SELO Gene

  • Selenoprotein O 3
  • SelO 4

External Ids for SELO Gene

Previous GeneCards Identifiers for SELO Gene

  • GC22P048821
  • GC22P048941
  • GC22P050639

Summaries for SELO Gene

Entrez Gene Summary for SELO Gene

  • This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]

GeneCards Summary for SELO Gene

SELO (Selenoprotein O) is a Protein Coding gene. Diseases associated with SELO include staphyloenterotoxemia. Among its related pathways are Selenium Metabolism and Selenoproteins and Selenium Pathway.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELO Gene

Genomics for SELO Gene

Regulatory Elements for SELO Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SELO Gene

Start:
50,200,979 bp from pter
End:
50,217,616 bp from pter
Size:
16,638 bases
Orientation:
Plus strand

Genomic View for SELO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SELO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELO Gene

Proteins for SELO Gene

  • Protein details for SELO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVL4-SELO_HUMAN
    Recommended name:
    Selenoprotein O
    Protein Accession:
    Q9BVL4
    Secondary Accessions:
    • Q2TAL2
    • Q5JZ81
    • Q8WUI0

    Protein attributes for SELO Gene

    Size:
    669 amino acids
    Molecular mass:
    73489 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH01099.3; Type=Erroneous termination; Positions=667; Note=Translated as Sec.; Evidence={ECO:0000305}; Sequence=AAH20510.1; Type=Erroneous termination; Positions=667; Note=Translated as Sec.; Evidence={ECO:0000305};

neXtProt entry for SELO Gene

Proteomics data for SELO Gene at MOPED

Post-translational modifications for SELO Gene

  • Ubiquitination at Lys377 and Lys621
  • Modification sites at PhosphoSitePlus

Other Protein References for SELO Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SELO Gene

Domains for SELO Gene

Protein Domains for SELO Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SELO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BVL4

UniProtKB/Swiss-Prot:

SELO_HUMAN :
  • Q9BVL4
Family:
  • Belongs to the UPF0061 (SELO) family.
genes like me logo Genes that share domains with SELO: view

No data available for Gene Families for SELO Gene

Function for SELO Gene

Phenotypes for SELO Gene

GenomeRNAi human phenotypes for SELO:
genes like me logo Genes that share phenotypes with SELO: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SELO Gene

Localization for SELO Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SELO Gene COMPARTMENTS Subcellular localization image for SELO gene
Compartment Confidence
mitochondrion 3
cytosol 2
extracellular 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SELO Gene

Pathways for SELO Gene

genes like me logo Genes that share pathways with SELO: view

Pathways by source for SELO Gene

2 BioSystems pathways for SELO Gene

Interacting Proteins for SELO Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000370288%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000225396%0d%0a9606.ENSP00000308022%0d%0a9606.ENSP00000357048%0d%0a
Selected Interacting proteins: ENSP00000370288 Q9BVL4-SELO_HUMAN for SELO Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SELO Gene

None

Transcripts for SELO Gene

Unigene Clusters for SELO Gene

Selenoprotein O:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SELO

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SELO

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELO Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: - - - - - - - -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6: - - -
SP7:
SP8: -
SP9: - -
SP10:

Relevant External Links for SELO Gene

GeneLoc Exon Structure for
SELO

Expression for SELO Gene

mRNA expression in normal human tissues for SELO Gene

mRNA differential expression in normal tissues according to GTEx for SELO Gene

This gene is overexpressed in Liver (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SELO Gene

SOURCE GeneReport for Unigene cluster for SELO Gene Hs.365405

genes like me logo Genes that share expressions with SELO: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SELO Gene

Orthologs for SELO Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SELO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 98 (a)
OneToOne
SELO 35
  • 97.24 (n)
  • 96.97 (a)
cow
(Bos Taurus)
Mammalia SELO 35
  • 84.06 (n)
  • 83.07 (a)
SELO 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 81 (a)
OneToOne
SELO 35
  • 85.36 (n)
  • 85.77 (a)
mouse
(Mus musculus)
Mammalia 1300018J18Rik 16
Selo 35
  • 80.09 (n)
  • 82.12 (a)
Selo 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Selo 35
  • 80.06 (n)
  • 82.57 (a)
chicken
(Gallus gallus)
Aves SELO 35
  • 70.7 (n)
  • 74.03 (a)
SELO 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia selo 35
  • 63.85 (n)
  • 66.23 (a)
zebrafish
(Danio rerio)
Actinopterygii selo 35
  • 60.5 (n)
  • 59.74 (a)
selo 36
  • 52 (a)
OneToMany
si:dkey-14d8.2 36
  • 51 (a)
OneToMany
wufd10b07 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FMP40 36
  • 25 (a)
OneToOne
soybean
(Glycine max)
eudicotyledons Gma.1585 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G13030 35
  • 48.83 (n)
  • 45.27 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.5200 35
rice
(Oryza sativa)
Liliopsida Os.9272 35
Os06g0320700 35
  • 51.05 (n)
  • 47.04 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToOne
Species with no ortholog for SELO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SELO Gene

ENSEMBL:
Gene Tree for SELO (if available)
TreeFam:
Gene Tree for SELO (if available)

Paralogs for SELO Gene

Selected SIMAP similar genes for SELO Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SELO: view

No data available for Paralogs for SELO Gene

Variants for SELO Gene

Sequence variations from dbSNP and Humsavar for SELO Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs760743 -- 50,208,946(+) TCCTA(C/T)TGGTA intron-variant
rs909687 -- 50,215,466(+) GGCAT(C/G)CGTGC intron-variant
rs2013430 -- 50,214,670(+) tgagg(C/T)aggag intron-variant
rs2013437 -- 50,214,437(+) CAACA(C/T)GGTGA intron-variant
rs2038049 -- 50,216,459(+) GCAGA(C/G)TGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SELO Gene

Variant ID Type Subtype PubMed ID
nsv915495 CNV Loss 21882294
dgv5051n71 CNV Loss 21882294
dgv5054n71 CNV Loss 21882294
dgv781n67 CNV Gain 20364138
dgv5055n71 CNV Loss 21882294
nsv829333 CNV Gain 20364138
dgv5056n71 CNV Loss 21882294
dgv5057n71 CNV Loss 21882294
nsv914515 CNV Gain 21882294
nsv471223 CNV Loss 18288195

Relevant External Links for SELO Gene

HapMap Linkage Disequilibrium report
SELO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELO Gene

Disorders for SELO Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SELO Gene including...

Search for SELO Gene in MalaCards »

(3) University of Copenhagen DISEASES for SELO Gene

genes like me logo Genes that share disorders with SELO: view

No data available for UniProtKB/Swiss-Prot for SELO Gene

Publications for SELO Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Characterization of mammalian selenoproteomes. (PMID: 12775843) Kryukov G.V. … Gladyshev V.N. (Science 2003) 3 4
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for SELO Gene

Sources for SELO Gene

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