SELO Gene
protein-coding GIFtS: 41
GCID: GC22P050639
|
|
SELO
| |
Aliases
for SELO gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Selenoprotein O2 | | SelO3 |
Export aliases for SELO gene to outside databasesPrevious GC identifers: GC22P048821 GC22P048941 |
Summaries
for SELO gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SELO:
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteineis encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have acommon stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Seccodon rather than as a stop signal. (provided by RefSeq, Jul 2008)
|
Genomic Views
for SELO gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011526.7
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SELO gene promoter:
Tal-1 HSF1 (long) Nkx5-1 E47 Arnt c-Myb HSF1short aMEF-2 MRF-2 TGIF
Other transcription factors
Search SABiosciences Chromatin IP Primers for SELO
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SELO |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.33 Ensembl cytogenetic band: 22q13.33 SELO Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P050639: view genomic region
(about GC identifiers)
Start:
|
50,639,408 bp from pter |
End:
|
50,656,045 bp from pter |
Size:
|
16,638 bases |
Orientation:
|
plus strand |
|
Proteins
for SELO gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SELO_HUMAN, Q9BVL4 (See
protein sequence)Recommended Name: Selenoprotein O Size: 669 amino acids; 73489 Da
Sequence caution: Sequence=AAH01099.3; Type=Erroneous termination; Positions=667; Note=Translated as Sec;Sequence=AAH20510.1; Type=Erroneous termination; Positions=667; Note=Translated as Sec;
Secondary accessions: Q2TAL2 Q5JZ81 Q8WUI0Explore the universe of human proteins at neXtProt for SELO: NX_Q9BVL4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BVL4
SELO Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_113642.1
ENSEMBL proteins: ENSP00000370288
Human Recombinant Protein Products:
SELO Antibody Products:
Assay Products for SELO: |
Protein
Domains /
Families
for SELO gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SELO for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BVL4ProtoNet protein and cluster: Q9BVL4 1 Blocks protein family: IPB003846 Protein of unknown function UPF0061
UniProtKB/Swiss-Prot: SELO_HUMAN, Q9BVL4Similarity: Belongs to the UPF0061 (SELO) family |
Function
for SELO gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SELO (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SELO
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SELO (NM_031454) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SELO | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELO |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELO |
1 GenomeRNAi human phenotype for SELO:
|
Pathways & Interactions
for SELO gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Selenium Metabolism and Selenoproteins | | | 2 | Selenium Pathway | |
2  BioSystems Pathways for SELO
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SELO
5/20 Interacting proteins for SELO (Q9BVL43) via UniProtKB, MINT, STRING, and/or I2D (see all 20)About this table
|
Drugs & Compounds
for SELO gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SELO
Search CenterWatch for drugs/clinical trials and news about SELO
|
Transcripts
for SELO gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SELO gene: NM_031454.1 Unigene Cluster for SELO: Selenoprotein O Hs.365405 [show with all ESTs]Unigene Representative Sequence: BC1108662 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000380903(uc021wry.1 uc010hap.3) ENST00000492092(uc003bjy.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SELO (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SELO
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SELO (NM_031454) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SELO | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELO |
Additional cDNA sequence: AF274946.1 AY324823.1 BC001099.2 BC020510.1 BC032384.1 BC051758.1 BC110866.1 CR456464.1 12 DOTS entries: DT.101982657 DT.408689 DT.97844290 DT.100795298 DT.86838431 DT.120652245 DT.100653327 DT.100765400 DT.97822475 DT.100775402 DT.40200037 DT.92027796 24/137 AceView cDNA sequences (see all 137): F31473 NM_031454 BI821344 AA250849 BM743224 CR611149 AW006853 BQ675785 CR615532 AI857861 AA828383 AW085907 BC032384 CR456464 BQ644294 BC020510 BG764573 BC001099 AI190634 AF274946 BM740855 AY324823 BM824246 BQ188392
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SELO (see all 10) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b |
|---|
|
| SP1: | | | | | - | | - | | - | | - | | | | | | | | | | - | | - | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
|
Expression
for SELO gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SELO expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGGCAGAGA
About this image
See SELO Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SELO
SOURCE GeneReport for Unigene cluster: Hs.365405
SABiosciences Custom PCR Arrays for SELO
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SELO
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SELO | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SELO | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SELO | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELO |
Orthologs
for SELO gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for SELO gene from 7/22 species (see all 22) About this table
ENSEMBL Gene Tree for SELO (if available)
TreeFam Gene Tree for SELO (if available) |
Paralogs
for SELO gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SELO gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SELO (50639408 - 50656045 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SELO: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SELO |
|
Disorders
/ Diseases
for SELO gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SELO for disorders About GeneDecksing
OMIM gene information: 607917
OMIM disorders: --
3  diseases for SELO: About MalaCardstoxic shock syndrome staphyloenterotoxemia mastitis
3 diseases from the University of Copenhagen DISEASES database for SELO:Toxic shock syndrome Staphyloenterotoxemia Mastitis Export disorders for SELO gene to outside databases
|
Publications
for SELO gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SELO gene integrated from 9 sources:
(articles sorted by number of sources associating them with SELO) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Characterization of mammalian selenoproteomes. (PubMed id 12775843)1, 2 Kryukov G.V.... Gladyshev V.N. (2003)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1 Collins J.E.... Dunham I. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Selenoproteins and maternal nutrition. (PubMed id 18790070)9 Pappas A.C....Zervas G. (2008)
|
External Searches for SELO gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SELO gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SELO gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SELO gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SELO gene:
Search GeneIP for patents involving SELO
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SELO gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SELO | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SELO | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SELO | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SELO | | OriGene 3'-UTR Clone for SELO | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SELO | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SELO | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SELO | | OriGene Custom Protein Services for SELO | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SELO | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SELO | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SELO | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SELO | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SELO | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SELO |
| |
 |  |  |  | |
| | | | Search Tocris compounds for SELO |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | SELO Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELO |
|  |  |  | | | | Search ThermoFisher Antibodies for SELO |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELO |
|
|
|
|
