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Aliases for SELM Gene

Aliases for SELM Gene

  • Selenoprotein M 3
  • SEPM 3 4 6
  • Selenoprotein SelM 3
  • SelM 4

External Ids for SELM Gene

Previous GeneCards Identifiers for SELM Gene

  • GC22M028196
  • GC22M029825
  • GC22M031500

Summaries for SELM Gene

Entrez Gene Summary for SELM Gene

  • This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This gene is expressed in a variety of tissues, and the protein is localized to the perinuclear structures. [provided by RefSeq, Jul 2008]

GeneCards Summary for SELM Gene

SELM (Selenoprotein M) is a Protein Coding gene. Diseases associated with SELM include staphyloenterotoxemia. Among its related pathways are Selenium Metabolism and Selenoproteins and Selenium Pathway.

UniProtKB/Swiss-Prot for SELM Gene

  • May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELM Gene

Genomics for SELM Gene

Regulatory Elements for SELM Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SELM Gene

31,104,772 bp from pter
31,120,069 bp from pter
15,298 bases
Minus strand

Genomic View for SELM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SELM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELM Gene

Proteins for SELM Gene

  • Protein details for SELM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Selenoprotein M
    Protein Accession:
    Secondary Accessions:
    • A8MPZ2

    Protein attributes for SELM Gene

    145 amino acids
    Molecular mass:
    16232 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SELM Gene

Proteomics data for SELM Gene at MOPED

Post-translational modifications for SELM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SELM Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SELM Gene

Domains for SELM Gene

Protein Domains for SELM Gene

Suggested Antigen Peptide Sequences for SELM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8WWX9
  • Belongs to the selenoprotein M/SEP15 family.
genes like me logo Genes that share domains with SELM: view

No data available for Gene Families for SELM Gene

Function for SELM Gene

Molecular function for SELM Gene

UniProtKB/Swiss-Prot Function:
May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation.

Gene Ontology (GO) - Molecular Function for SELM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SELM: view
genes like me logo Genes that share phenotypes with SELM: view

Animal Models for SELM Gene

MGI Knock Outs for SELM:
  • Selm tm1(KOMP)Vlcg

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SELM

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SELM Gene

Localization for SELM Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELM Gene

Cytoplasm, perinuclear region. Endoplasmic reticulum. Golgi apparatus. Note=Localized to perinuclear structures corresponding to Golgi and endoplasmic reticulum.

Subcellular locations from

Jensen Localization Image for SELM Gene COMPARTMENTS Subcellular localization image for SELM gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 4
nucleus 4
cytosol 3
extracellular 3

Gene Ontology (GO) - Cellular Components for SELM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with SELM: view

Pathways for SELM Gene

genes like me logo Genes that share pathways with SELM: view

Pathways by source for SELM Gene

2 BioSystems pathways for SELM Gene

Interacting Proteins for SELM Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000383155 Q8WWX9-SELM_HUMAN for SELM Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for SELM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010269 response to selenium ion --
GO:0035264 multicellular organism growth --
GO:0035934 corticosterone secretion --
GO:0042445 hormone metabolic process --
GO:0060612 adipose tissue development --
genes like me logo Genes that share ontologies with SELM: view

Compounds for SELM Gene

(2) HMDB Compounds for SELM Gene

Compound Synonyms Cas Number PubMed IDs
  • selenium
  • (2R)-2-amino-3-selanylpropanoate

(1) Novoseek inferred chemical compound relationships for SELM Gene

Compound -log(P) Hits PubMed IDs
selenium 69.9 4
genes like me logo Genes that share compounds with SELM: view

Transcripts for SELM Gene

Unigene Clusters for SELM Gene

Selenoprotein M:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SELM

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELM Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: - - -

Relevant External Links for SELM Gene

GeneLoc Exon Structure for

Expression for SELM Gene

mRNA expression in normal human tissues for SELM Gene

Protein differential expression in normal tissues for SELM Gene

This gene is overexpressed in Oral epithelium (14.2) and Skin (12.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SELM Gene

SOURCE GeneReport for Unigene cluster for SELM Gene Hs.55940

mRNA Expression by UniProt/SwissProt for SELM Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with SELM: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for SELM Gene

Orthologs for SELM Gene

This gene was present in the common ancestor of chordates.

Orthologs for SELM Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SELM 35
  • 83.88 (n)
  • 83.61 (a)
  • 79 (a)
(Canis familiaris)
Mammalia SELM 35
  • 85.4 (n)
  • 85.12 (a)
(Mus musculus)
Mammalia Selm 35
  • 84.59 (n)
  • 85.71 (a)
Selm 16
Selm 36
  • 83 (a)
(Pan troglodytes)
Mammalia SELM 35
  • 99.08 (n)
  • 99.31 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Selm 35
  • 83.75 (n)
  • 85.71 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
(Gallus gallus)
Aves SELM 35
  • 75.33 (n)
  • 79 (a)
  • 60 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia selm 35
  • 64.51 (n)
  • 66.67 (a)
Str.10296 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16264 35
(Danio rerio)
Actinopterygii selm 35
  • 66.67 (n)
  • 73.15 (a)
sepm 35
selm 36
  • 54 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8755 35
Species with no ortholog for SELM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SELM Gene

Gene Tree for SELM (if available)
Gene Tree for SELM (if available)

Paralogs for SELM Gene

No data available for Paralogs for SELM Gene

Variants for SELM Gene

Sequence variations from dbSNP and Humsavar for SELM Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs2283875 -- 31,105,847(+) CTCCC(C/T)GCCCC intron-variant
rs7289262 -- 31,107,595(+) ccccg(C/G)ccccg upstream-variant-2KB
rs11705035 -- 31,106,076(+) ATCCC(C/T)GGATC intron-variant
rs11705054 -- 31,105,995(+) GTCAG(A/G)AGTCC intron-variant
rs11705064 -- 31,106,201(+) AGACC(A/C)ACAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SELM Gene

Variant ID Type Subtype PubMed ID
nsv9896 CNV Gain 18304495
nsv829173 CNV Loss 20364138
dgv4956n71 CNV Loss 21882294
nsv914976 CNV Loss 21882294

Relevant External Links for SELM Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELM Gene

Disorders for SELM Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SELM Gene in MalaCards »

(1) Diseases for SELM Gene including...

(3) University of Copenhagen DISEASES for SELM Gene

Relevant External Links for SELM

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SELM: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for SELM Gene

Publications for SELM Gene

  1. Mammalian selenoprotein in which selenocysteine (Sec) incorporation is supported by a new form of Sec insertion sequence element. (PMID: 11839807) Korotkov K.V. … Gladyshev V.N. (Mol. Cell. Biol. 2002) 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PMID: 21048031) Casabonne D. … de Sanjose S. (Haematologica 2011) 3
  5. Galectin-1 is an interactive protein of selenoprotein M in the brain. (PMID: 24284396) Qiao X. … Liu Q. (Int J Mol Sci 2013) 3

Products for SELM Gene

Sources for SELM Gene

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