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Aliases for SELM Gene

Aliases for SELM Gene

  • Selenoprotein M 3
  • SEPM 3 4
  • Selenoprotein SelM 3
  • SelM 4

External Ids for SELM Gene

Previous GeneCards Identifiers for SELM Gene

  • GC22M028196
  • GC22M029825
  • GC22M031500

Summaries for SELM Gene

Entrez Gene Summary for SELM Gene

  • This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This gene is expressed in a variety of tissues, and the protein is localized to the perinuclear structures. [provided by RefSeq, Jul 2008]

GeneCards Summary for SELM Gene

SELM (Selenoprotein M) is a Protein Coding gene. Among its related pathways are Selenium Metabolism and Selenoproteins and Selenium Pathway.

UniProtKB/Swiss-Prot for SELM Gene

  • May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELM Gene

Genomics for SELM Gene

Regulatory Elements for SELM Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SELM Gene

Chromosome:
22
Start:
31,104,772 bp from pter
End:
31,120,069 bp from pter
Size:
15,298 bases
Orientation:
Minus strand

Genomic View for SELM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SELM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELM Gene

Proteins for SELM Gene

  • Protein details for SELM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWX9-SELM_HUMAN
    Recommended name:
    Selenoprotein M
    Protein Accession:
    Q8WWX9
    Secondary Accessions:
    • A8MPZ2

    Protein attributes for SELM Gene

    Size:
    145 amino acids
    Molecular mass:
    16232 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SELM Gene

Proteomics data for SELM Gene at MOPED

Post-translational modifications for SELM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SELM Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SELM Gene

Domains & Families for SELM Gene

Protein Domains for SELM Gene

Suggested Antigen Peptide Sequences for SELM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWX9

UniProtKB/Swiss-Prot:

SELM_HUMAN :
  • Belongs to the selenoprotein M/SEP15 family.
Family:
  • Belongs to the selenoprotein M/SEP15 family.
genes like me logo Genes that share domains with SELM: view

No data available for Gene Families for SELM Gene

Function for SELM Gene

Molecular function for SELM Gene

UniProtKB/Swiss-Prot Function:
May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation.

Gene Ontology (GO) - Molecular Function for SELM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SELM: view
genes like me logo Genes that share phenotypes with SELM: view

Animal Models for SELM Gene

MGI Knock Outs for SELM:
  • Selm tm1(KOMP)Vlcg

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SELM

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for SELM Gene

Localization for SELM Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELM Gene

Cytoplasm, perinuclear region. Endoplasmic reticulum. Golgi apparatus. Note=Localized to perinuclear structures corresponding to Golgi and endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SELM Gene COMPARTMENTS Subcellular localization image for SELM gene
Compartment Confidence
nucleus 4
endoplasmic reticulum 3
golgi apparatus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SELM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with SELM: view

Pathways & Interactions for SELM Gene

genes like me logo Genes that share pathways with SELM: view

Pathways by source for SELM Gene

2 BioSystems pathways for SELM Gene

Interacting Proteins for SELM Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000383155%0d%0a9606.ENSP00000392057%0d%0a9606.ENSP00000354929%0d%0a
Selected Interacting proteins: Q8WWX9-SELM_HUMAN ENSP00000383155 for SELM Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for SELM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010269 response to selenium ion --
GO:0035264 multicellular organism growth --
GO:0035934 corticosterone secretion --
GO:0042445 hormone metabolic process --
GO:0060612 adipose tissue development --
genes like me logo Genes that share ontologies with SELM: view

No data available for SIGNOR curated interactions for SELM Gene

Drugs & Compounds for SELM Gene

(2) Drugs for SELM Gene - From: HMDB and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenocysteine Experimental Pharma 0
Selenium Pharma 161
genes like me logo Genes that share compounds with SELM: view

Transcripts for SELM Gene

Unigene Clusters for SELM Gene

Selenoprotein M:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SELM

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELM Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: - - -
SP7:

Relevant External Links for SELM Gene

GeneLoc Exon Structure for
SELM

Expression for SELM Gene

mRNA expression in normal human tissues for SELM Gene

Protein differential expression in normal tissues from HIPED for SELM Gene

This gene is overexpressed in Oral epithelium (14.2) and Skin (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SELM Gene



SOURCE GeneReport for Unigene cluster for SELM Gene Hs.55940

mRNA Expression by UniProt/SwissProt for SELM Gene

Q8WWX9-SELM_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with SELM: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for SELM Gene

Orthologs for SELM Gene

This gene was present in the common ancestor of chordates.

Orthologs for SELM Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SELM 35
  • 83.88 (n)
  • 83.61 (a)
SELM 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SELM 35
  • 85.4 (n)
  • 85.12 (a)
mouse
(Mus musculus)
Mammalia Selm 35
  • 84.59 (n)
  • 85.71 (a)
Selm 16
Selm 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SELM 35
  • 99.08 (n)
  • 99.31 (a)
SELM 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Selm 35
  • 83.75 (n)
  • 85.71 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves SELM 35
  • 75.33 (n)
  • 79 (a)
SELM 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia selm 35
  • 64.51 (n)
  • 66.67 (a)
Str.10296 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16264 35
zebrafish
(Danio rerio)
Actinopterygii selm 35
  • 66.67 (n)
  • 73.15 (a)
sepm 35
selm 36
  • 54 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8755 35
Species with no ortholog for SELM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SELM Gene

ENSEMBL:
Gene Tree for SELM (if available)
TreeFam:
Gene Tree for SELM (if available)

Paralogs for SELM Gene

No data available for Paralogs for SELM Gene

Variants for SELM Gene

Sequence variations from dbSNP and Humsavar for SELM Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs35563586 -- 31,105,527(+) CTCAG(-/T)AATCC intron-variant
rs62236156 -- 31,105,424(+) TATAC(C/G)TGAGA intron-variant
rs111892290 -- 31,105,288(+) GTGAC(A/T)GGAGG splice-acceptor-variant
rs112745491 -- 31,105,657(+) GGATA(A/C/G)TAGAA splice-donor-variant
rs113646123 -- 31,105,287(+) TGTGA(C/G/T)TGGAG splice-acceptor-variant

Structural Variations from Database of Genomic Variants (DGV) for SELM Gene

Variant ID Type Subtype PubMed ID
nsv9896 CNV Gain 18304495
nsv829173 CNV Loss 20364138
dgv4956n71 CNV Loss 21882294
nsv914976 CNV Loss 21882294

Variation tolerance for SELM Gene

Residual Variation Intolerance Score: 62.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELM Gene

HapMap Linkage Disequilibrium report
SELM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELM Gene

Disorders for SELM Gene

Relevant External Links for SELM

Human Genome Epidemiology (HuGE) Navigator
SELM
genes like me logo Genes that share disorders with SELM: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SELM Gene

Publications for SELM Gene

  1. The neuroprotective functions of selenoprotein M and its role in cytosolic calcium regulation. (PMID: 19769485) Reeves M.A. … Berry M.J. (Antioxid. Redox Signal. 2010) 23 67
  2. ERK activation induced by selenium treatment significantly downregulates beta/gamma-secretase activity and Tau phosphorylation in the transgenic rat overexpressing human selenoprotein M. (PMID: 19513540) Yim S.Y. … Hwang D.Y. (Int. J. Mol. Med. 2009) 23 67
  3. Selenoproteins and maternal nutrition. (PMID: 18790070) Pappas A.C. … Zervas G. (Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 2008) 23 67
  4. Overexpression of human selenoprotein M differentially regulates the concentrations of antioxidants and H2O2, the activity of antioxidant enzymes, and the composition of white blood cells in a transgenic rat. (PMID: 18204783) Hwang D.Y. … Chae K.R. (Int. J. Mol. Med. 2008) 23 67
  5. NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family. (PMID: 16319061) Ferguson A.D. … Deisenhofer J. (J. Biol. Chem. 2006) 23 67

Products for SELM Gene

Sources for SELM Gene

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