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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SELL Gene

protein-coding GIFtS: 70
GCID: GC01M169659

selectin L

(Previous name: lymphocyte adhesion molecule 1 )
(Previous symbols: LYAM1, LNHR)

Explore 142 diseases affiliated with
SELL via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Selectin L¹ ²		LECAM1² ³
LNHR¹ ² ³ ⁵		TQ1² ³
LYAM1¹ ² ³ ⁵		CD62 Antigen-Like Family Member L² ³
LAM1¹ ² ⁵		Gp90-MEL¹
CD62L¹ ²		Leu-8¹
LSEL¹ ²		Lyam-1¹
PLNHR¹ ²		HLHRc¹
Lymphocyte Adhesion Molecule 1¹ ²		L-Selectin¹
LAM-1¹ ³		LEU8²
Leukocyte Surface Antigen Leu-8² ³		Pln Homing Receptor²
Leukocyte-Endothelial Cell Adhesion Molecule 1² ³		CD62L Antigen³
Lymph Node Homing Receptor² ³		Leukocyte Adhesion Molecule 1³

External Ids:	HGNC: 10720¹	Entrez Gene: 6402²	Ensembl: ENSG00000188404⁷	OMIM: 153240⁵	UniProtKB: P14151³

ORGUL members:
	NONCODE:n335165 n408378

Export aliases for SELL gene to outside databases

Previous GC identifers: GC01M167288 GC01M165310 GC01M166180 GC01M166672 GC01M166847 GC01M166391 GC01M167926 GC01M140882

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SELL:

This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded

protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short

complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial

cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide

polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy.

Alternatively spliced transcript variants have been found for this gene. (provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: LYAM1_HUMAN, P14151

Function: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial

venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia

Gene Wiki entry for SELL (L-selectin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SELL gene promoter:
GR STAT3 PPAR-gamma2 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SELL promoter sequence

Search SABiosciences Chromatin IP Primers for SELL

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SELL

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23-q25 Ensembl cytogenetic band: 1q24.2 HGNC cytogenetic band: 1q23-q25

SELL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SELL gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M169659: view genomic region (about GC identifiers)

Start:	169,659,806 bp from pter	End:	169,680,843 bp from pter
Size:	21,038 bases	Orientation:	minus strand

ORGUL member locations:
Legend (see complete legend)

n408378
n335165

lncRNA
Full Legend

169659805 169668901 169677997 chr1

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LYAM1_HUMAN, P14151 (See protein sequence)

Recommended Name: L-selectin precursor

Size: 372 amino acids; 42187 Da

Subunit: Interaction with PSGL1/SELPLG and PODXL2 is required for promoting recruitment and rolling of leukocytes. This

interaction is dependent on the sialyl Lewis X glycan modification of PSGL1 and PODXL2, and tyrosine sulfation

modifications of PSGL1. Sulfation on 'Tyr-51' of PSGL1 is important for L-selectin binding

Subcellular location: Membrane; Single-pass type I membrane protein

Sequence caution: Sequence=CAA34203.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Sequence=CAB43536.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAB43537.1;

Type=Erroneous initiation; Note=Translation N-terminally shortened;

3 PDB 3D structures from and Proteopedia for SELL:

1KJB (3D)

2LGF (3D)

3CFW (3D)

Secondary accessions: B2R6Q8 P15023 Q9UJ43

Alternative splicing: 2 isoforms: P14151-1 P14151-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SELL: NX_P14151

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P14151

SELL Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000646.2

ENSEMBL proteins:

ENSP00000236147

Reactome Protein details: P14151
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals SELL Proteins Novus Biologicals SELL Lysates
	Sino Biological Recombinant Protein for SELL
	ProSpec Recombinant Protein for SELL
	Uscn Proteins for SELL

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	1692315
GO:0009897	external side of plasma membrane	IEA	--

SELL for ontologies About GeneDecksing

SELL Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of SELL
	R&D Systems Antibodies for SELL (L-Selectin/CD62L)
	Browse OriGene Antibodies OriGene Custom Antibody Services for SELL
	GenScript Custom Superior Antibodies Services for SELL
	Novus Biologicals SELL Antibodies
	Abcam antibodies for SELL
	Uscn Antibodies for SELL
	ThermoFisher Antibody for SELL

Assay Products for SELL:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for SELL (L-Selectin/CD62L) (see all)
	GenScript Custom Assay Services for SELL
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SELL

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SELL for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR016187 C-type_lectin_fold

IPR002396 Selectin_superfamily

IPR000742 EG-like_dom

IPR018378 C-type_lectin_CS

IPR016186 C-type_lectin-like

Graphical View of Domain Structure for InterPro Entry P14151

ProtoNet protein and cluster: P14151

3 Blocks protein families:

IPB000436 Sushi domain/SCR domain/CCP module

IPB002396 Selectin superfamily complement-binding repeat signature

IPB006210 Type I EGF

UniProtKB/Swiss-Prot: LYAM1_HUMAN, P14151

Similarity: Belongs to the selectin/LECAM family

Similarity: Contains 1 C-type lectin domain

Similarity: Contains 1 EGF-like domain

Similarity: Contains 2 Sushi (CCP/SCR) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: LYAM1_HUMAN, P14151

Function: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial

venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia

Genatlas biochemistry entry for SELL:

L selectin,leukocyte adhesion molecule,74kDa,constitutively expressed on monocytes,thymocytes,NK

cells,granulocytes,lymph node homing receptor,binding to MCAM1,CD34

miRNA Products:		OriGene 3'-UTR Clone: SELL Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SELL
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SELL
		SwitchGear 3'UTR luciferase reporter plasmid: SELL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SELL (see all 7) OriGene shRNA RFP: SELL OriGene siRNA: SELL
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SELL

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SELL

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: SELL (NM_000655)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SELL
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELL

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SELL
		Search LifeMap BioReagents cell lines for SELL

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELL

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002020	protease binding	IPI	17548643
GO:0005515	protein binding	IPI	18606703
GO:0008201	heparin binding	TAS	7680663
GO:0030246	carbohydrate binding	IEA	--
GO:0043208	glycosphingolipid binding	TAS	7680663

SELL for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SELL:

Increased gamma-H2AX phosphory

Animal Models:
     Mouse knock-outs for SELL: Sell^tm3Tft Sell^tm1Hyn Sell^tm4Hyn Sell^tm2Alb Sell^tm1Pest Sell^tm2Hyn
                                               Sell^tm1Tft Sell^tm1Alb Sell^tm1Flv Sell^tm3Hyn
     11 MGI mutant phenotypes (inferred from 12 alleles) (MGI details for Sell):

cardiovascular system	cellular	endocrine/exocrine gland	growth/size	hematopoietic system
homeostasis/metabolism	immune system	integument	liver/biliary system	respiratory system
tumorigenesis

SELL for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell adhesion_Cell-matrix glycoconjugates

Cell adhesion_Cell-matrix glycoconjugates

1.00

Cell adhesion Cell-matrix glycoconjugates

0.97

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Cell adhesion molecules (CAMs)

Cell adhesion molecules (CAMs)

1.00

Cell surface interactions at the vascular wall

Cell surface interactions at the vascular wall

1.00

Platelet activation, signaling and aggregation

Hemostasis

0.43

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for SELL

Cell adhesion Cell-matrix glycoconjugates

1 GeneGo (Thomson Reuters) Pathway for SELL

Cell adhesion Cell-matrix glycoconjugates

5 Reactome Pathways for SELL

	Hemostasis
	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
	Adaptive Immune System
	Cell surface interactions at the vascular wall
	Immune System

1 Kegg Pathway (Kegg details for SELL):

Cell adhesion molecules (CAMs)

SELL for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SELL

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/20 Interacting proteins for SELL (P14151³ ENSP00000236147⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EZR	P15311³, ENSP00000338934⁴	I2D: score=2 STRING: ENSP00000338934
EMCN	Q9ULC0³, ENSP00000296420⁴	I2D: score=1 STRING: ENSP00000296420
MUC7	Q8TAX7³, ENSP00000302021⁴	I2D: score=1 STRING: ENSP00000302021
SELE	P16581³, ENSP00000331736⁴	I2D: score=1 STRING: ENSP00000331736
SELPLG	Q14242³, ENSP00000373614⁴	I2D: score=1 STRING: ENSP00000373614

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	IEA	--
GO:0007596	blood coagulation	TAS	--
GO:0033198	response to ATP	IEA	--
GO:0050776	regulation of immune response	TAS	--
GO:0050900	leukocyte migration	TAS	--

SELL for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SELL for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SELL

1 HMDB Compound for SELL About this table

Compound	Synonyms	CAS #	PubMed Ids
3-O-Sulfogalactosylceramide (d18:1/24:0)	Sulfatide (d18:1/24:0) (see all 16)	151122-71-3	7534512

10/94 Novoseek chemical compound relationships for SELL gene (see all 94) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
slex	82.9	48	11053118 (4), 7473003 (3), 1716182 (3), 11017914 (2) (see all 32)
ppme	81.8	12	7556772 (2), 1709244 (1), 1712791 (1), 9763619 (1) (see all 6)
fmlp	75.2	66	1709192 (3), 7515857 (2), 7517990 (2), 14699606 (2) (see all 42)
fucoidan	71.5	36	7556772 (2), 15609279 (2), 1712791 (1), 7532138 (1) (see all 19)
n-formylmethionyl-leucylphenylalanine	70	21	7513653 (2), 9544581 (1), 8656052 (1), 10625005 (1) (see all 17)
slea	54.8	4	9430509 (2), 1281614 (1), 7561686 (1)
sialic acid	50.4	13	8547663 (2), 9400621 (2), 11217952 (1), 8893560 (1) (see all 9)
cuprophan	49.3	8	9890318 (3), 11721441 (1), 9002533 (1), 7503138 (1) (see all 5)
tyrosine sulfate	48.8	1	9414280 (1)
polylactosamine	46.3	4	9184825 (2), 10725346 (1), 11095659 (1)

Search CenterWatch for drugs/clinical trials and news about SELL / LYAM1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SELL gene:

NM_000655.4

Unigene Cluster for SELL:

Selectin L

Hs.728756 [show with all ESTs]

Unigene Representative Sequence: NM_000655

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000236147(uc010pls.2 uc001ggk.3) ENST00000497295 ENST00000463108(uc001ggl.2)

ENST00000460650 ENST00000479657 ENST00000466340

miRNA Products:		OriGene 3'-UTR Clone: SELL Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SELL
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SELL
		SwitchGear 3'UTR luciferase reporter plasmid: SELL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SELL (see all 7) OriGene shRNA RFP: SELL OriGene siRNA: SELL
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SELL

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SELL (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SELL OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SELL (NM_000655)
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SELL Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SELL
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SELL
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SELL

Additional cDNA sequence:

AJ246000.1 AK225713.1 AK298705.1 AK312673.1 AY367061.1 BC020758.1 M25280.1 NR_029467.1

X16070.1 X16150.1 X17519.1

11 DOTS entries:

DT.315776 DT.100777337 DT.100696868 DT.100746103 DT.121415857 DT.315777 DT.100777339 DT.121415772

DT.121415774 DT.91679424 DT.95147243

24/150 AceView cDNA sequences (see all 150):

BC020758 AW440912 NM_000655 AW083158 AW474651 BX339329 AI434565 AA355761

BM972403 AJ246000 BM477130 AV654869 CA411781 AI026163 AI572987 CB153195

BQ003754 BP346240 AI253539 BF902611 AY367061 CD693446 CD706480 BF905643

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SELL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAATTTTGCA

About this image

SELL expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Body Subcutaneous White Adipose

Adipose

Thoracic Perivascular Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SELL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SELL

SOURCE GeneReport for Unigene cluster: Hs.728756

UniProtKB/Swiss-Prot: LYAM1_HUMAN, P14151

Tissue specificity: Expressed in B-cell lines and T-lymphocytes

SABiosciences Expression via Pathway-Focused PCR Arrays including SELL (see all 6):

HIV Host Response in human mouse rat

Extracellular Matrix & Adhesion Molecules in human mouse rat

Endothelial Cell Biology in human mouse rat

Atherosclerosis in human mouse rat

T-Cell Anergy & Immune Tolerance in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SELL Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SELL
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SELL
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SELL

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELL

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SELL gene from 3/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SELP⁶	Uncharacterized protein	21(a)	1 ↔ 1	8(3730893-3737709)
lizard (Anolis carolinensis)	Reptilia	--	--		possible ortholog	GL343567.1(230131-410791)
fruit fly (Drosophila melanogaster)	Insecta	hig⁶	hikaru genki	4(a)	possible ortholog	2R(5115286-5134752)

ENSEMBL Gene Tree for SELL (if available)
TreeFam Gene Tree for SELL (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SELL gene

CSMD1² SEZ6L2² SELP² C4BPA² CR2² CR1L² CSMD3² SEZ6²

SELE² SEZ6L² CSMD2² CR1² CD55² CD46² SVEP1²

2 SIMAP similar genes for SELL using alignment to 2 protein entries: LYAM1_HUMAN (see all proteins):

SELE SELP

SELL for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4987385^1,2	C,	--	140881844(-)	`TTTTCT/CTTCTC`	2	--	ds500¹		3		NS WA	210
rs12065232^1,2	C,	--	140882178(+)	`GGGGAG/AANNNN`	2	--	ds500¹		2		CSA WA	120
rs4987406^1,2	C	--	140882705(-)	`CAGTT-/AGTT GGCTG`	2	--	nc-transcript-variantut3¹		2		NS	86
rs112080902^1,2	C,	--	140882742(+)	`GGAGGC/ATGAAG`	2	--	nc-transcript-variantut3¹		1		WA	2
rs4987383^1,2	C,F,H,	--	140882778(-)	`TCGCCG/ATCTGT`	2	--	nc-transcript-variantut3¹		7		NS NA	594
rs113659067^1,2	C,	--	140882784(+)	`GGCGAG/AGCTAC`	2	--	nc-transcript-variantut3¹		1		WA	2
rs909628^1,2	C,F,O,H,	--	140883084(+)	`CCTTTA/GTGGTC`	2	--	nc-transcript-variantut3¹ ese³		35		NA EA MN NS WA	3763
rs4987381^1,2	C,F,H,	--	140883599(-)	`AGTCTG/TCATTT`	2	--	int¹		8		NS EA NA	636
rs41272473^1,2		--	140883660(+)	`TCTTTA/CGTGAT`	2	--	int¹		0	--	--	--	--
rs4987380^1,2	C,F,H,	--	140883688(-)	`GTGGGG/TTCTGT`	2	--	int¹		6		NS EA	514

HapMap Linkage Disequilibrium report for SELL (169659806 - 169680843 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SELL
1 Indel: 58348
Human Gene Mutation Database (HGMD): SELL

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SELL

DNA2.0 Custom Variant and Variant Library Synthesis for SELL

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SELL for disorders           About GeneDecksing

OMIM gene information: 153240
OMIM disorders: 161950
20/142 diseases for SELL (see all 142):    About MalaCards

hyper-ige syndrome nephropathy graft versus host disease common variable immunodeficiency

arthus reaction hypersensitivity reaction type ii disease human immunodeficiency virus infectious disease otitis media

cryptococcosis pre-eclampsia abdominal aortic aneurysm bronchopulmonary dysplasia

familial mediterranean fever non-hodgkin lymphoma type 2 diabetes mellitus aortic aneurysm

type 1 diabetes mellitus diabetes mellitus inflammatory bowel disease myocardial infarction

1 disease from the University of Copenhagen DISEASES database for SELL:

Vascular disease

10/94 Novoseek disease relationships for SELL gene (see all 94) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	69.8	141	19303986 (3), 8614468 (2), 16740600 (2), 19889515 (2) (see all 99)
leukocyte adhesion deficiency syndrome	58.5	1	10419878 (1)
necrosis	51.5	63	8546574 (2), 7527508 (1), 8813119 (1), 9844766 (1) (see all 55)
lymphocytic leukemia chronic b-cell	45.1	4	7520409 (1), 7690438 (1)
systemic inflammatory response syndrome	43.8	7	8546574 (1), 8911253 (1), 10966248 (1), 8959352 (1)
lymphopenia	34.7	1	15039250 (1)
leukocytosis	34.1	1	9865459 (1)
sepsis	33.2	36	11176170 (4), 19011162 (2), 9161833 (2), 9517615 (2) (see all 22)
cryptococcosis disseminated	29.4	3	15776384 (2)
rheumatoid arthritis	27	10	7543837 (1), 8961381 (1), 9133922 (1), 8857959 (1) (see all 9)

Genetic Association Database (GAD): SELL
Human Genome Epidemiology (HuGE) Navigator: SELL (45 documents)

Export disorders for SELL gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SELL gene, integrated from 9 sources (see all 1363):
(articles sorted by number of sources associating them with SELL)

Utopia: connect your pdf to the dynamic
world of online information

Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains. (PubMed id 2664786)^{1, 2, 3} Siegelman M.H. and Weissman I.L. (1989)
Structure of the gene encoding the human leukocyte adhesion molecule- 1 (TQ1, Leu-8) of lymphocytes and neutrophils. (PubMed id 1692315)^{1, 2, 9} Ord D.C....Tedder T.F. (1990)
Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin. (PubMed id 12736247)^{1, 2, 9} Leppaenen A.... Cummings R.D. (2003)
Leukocyte-endothelial cell adhesion molecule 1 (LECAM-1) polymorphism is associated with diabetic nephropathy in type 2 diabetes mellitus. (PubMed id 12200076)^{1, 4, 9} Kamiuchi K....Nakamura N. (2002)
Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen. (PubMed id 12871600)^{1, 4, 9} Adams G.T....Kutlar A. (2003)
L-selectin gene T668C mutation in type 1 diabetes patients and their first degree relatives. (PubMed id 11064106)^{1, 4, 9} Kretowski A. and Kinalska I. (2000)
Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins. (PubMed id 18606703)^{1, 2} Kerr S.C....Rosen S.D. (2008)
Association of the Phe206Leu allele of the L-selectin gene with coronary artery disease. (PubMed id 16357481)^{1, 4} Hajilooi M....Massoud A. (2006)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
Variation in immune response genes and chronic Q fever. Concepts: preliminary test with post-Q fever fatigue syndrome. (PubMed id 12595908)^{1, 4} Helbig K.J....Marmion B.P. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6402	HGNC: 10720	AceView: SELL	Ensembl:ENSG00000188404	euGenes: HUgn6402
ECgene: SELL	Kegg: 6402	H-InvDB: SELL

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SELL	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SELL	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/sell/
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_234

Intellectual Property for SELL gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SELL gene:
Search GeneIP for patents involving SELL

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	EMD Millipore Mono- and Polyclonal Antibodies for the study of SELL
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SELL Gene

selectin L

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SELL (Gene Symbol)
Selectin L
LNHR
LYAM1
LAM1
CD62L
LSEL
PLNHR
Lymphocyte Adhesion Molecule 1
LAM-1
Leukocyte Surface Antigen Leu-8
Leukocyte-Endothelial Cell Adhesion Molecule 1
Lymph Node Homing Receptor
LECAM1
TQ1
CD62 Antigen-Like Family Member L
Gp90-MEL
Leu-8
Lyam-1
HLHRc
L-Selectin
LEU8
Pln Homing Receptor
CD62L Antigen
Leukocyte Adhesion Molecule 1

Leukocyte Adhesion Deficiency Syndrome
sepsis
Dermatitis Atopic
Allergic Reaction
Colitis Ulcerative
CRYPTOCOCCOSIS DISSEMINATED
COLON CARCINOMA
Arthus Reaction
Skin Diseases
Atherosclerosis
Breast Cancer
Respiratory Distress Syndrome
Edema
Stress Psychological
ALVEOLITIS
Adenocarcinoma
Asthma
BILIARY CIRRHOSIS PRIMARY
Cancer
Obstruction
Bronchopulmonary Dysplasia
Aneurysm
Lymphocytosis
Lymphoma
RENAL DISEASE
Bronchoalveolar Lavage Fluid
Sarcoidosis Pulmonary
Nephropathy IGA
Inflammation
Tuberculosis
SICKLE CELL DISEASE
immunodeficiency
Hepatitis
MYELOMA
Renal Failure
HYPER-IgE SYNDROME
Rheumatoid Arthritis
Pneumonia
Tumors
Metastasis
Kawasaki Disease
Autoimmunity
Necrosis
Lymphoblastic Leukemia Acute
Asthma allergic
Lymphoma T-Cell Cutaneous
Preeclampsia
Tachycardia
Chronic Disease
Paroxysmal Hemoglobinuria Nocturnal
Shock Septic
Gastric Cancer
Lymphadenopathy
Autoimmune Diseases
Vasculitis
Leukemia Lymphocytic Chronic
inflammatory joint disease
GOITER TOXIC NODULAR
Systemic Inflammatory Response Syndrome
Leukocytosis
Carcinoma
Bacterial Infections
INFARCT
ACUTE LEUKEMIA
Common Variable Immunodeficiency
Leukemia
Diabetes Mellitus
Diabetic Retinopathy
Agranulocytosis
CMV INFECTION
Lymphopenia
SEPSIS NEONATAL
Cancer Lung
Myocardial Infarction
Inflammatory Bowel Diseases
Multiple Organ Failure
Acute bronchiolitis
Insulin Resistance
HIV Infections
Bleeding
BEHCET DISEASE
Lymphocytic Leukemia Chronic B-Cell
OBESITY
Carcinoma Squamous Cell
Cryptococcosis
SKIN LESION
STROKE
Graves Disease
Graft-Versus-Host Disease
Lymphoma Non-Hodgkins
NIDDM
Sclerosis Systemic
Myelodysplastic Syndromes
LEUKAEMIA LYMPHOCYTIC

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SELL Gene

selectin L

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