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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SELL Gene

protein-coding   GIFtS: 69
GCID: GC01M169659

Selectin L

(Previous name: lymphocyte adhesion molecule 1)
(Previous symbols: LYAM1, LNHR)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Selectin L1 2     LAM12 5
LNHR1 2 3 5     CD62L2
LYAM11 2 3 5     L-selectin2
Lymphocyte Adhesion Molecule 11 2     LEU82
Leukocyte Surface Antigen Leu-82 3     LSEL2
Leukocyte-Endothelial Cell Adhesion Molecule 12 3     PLNHR2
Lymph Node Homing Receptor2 3     Pln Homing Receptor2
LECAM12 3     LAM-13
TQ12 3     CD62L Antigen3
CD62 Antigen-Like Family Member L2 3     Leukocyte Adhesion Molecule 13
gp90-MEL2 3     

External Ids:    HGNC: 107201   Entrez Gene: 64022   Ensembl: ENSG000001884047   OMIM: 1532405   UniProtKB: P141513   
ORGUL members:         
NONCODE14:n408378 n335165      

Export aliases for SELL gene to outside databases

Previous GC identifers: GC01M167288 GC01M165310 GC01M166180 GC01M166672 GC01M166847 GC01M166391 GC01M167926 GC01M140882


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SELL Gene:
This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The
encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and
two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes
on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites.
Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin
A nephropathy. Alternatively spliced transcript variants have been found for this gene. (provided by RefSeq, Oct
2009)

GeneCards Summary for SELL Gene: 
SELL (selectin L) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with SELL include cryptococcosis, and arthus reaction, and among its related super-pathways are Immune System and Cell adhesion Cell-matrix glycoconjugates. GO annotations related to this gene include carbohydrate binding and protease binding.

UniProtKB/Swiss-Prot: LYAM1_HUMAN, P14151
Function: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high
endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia

Gene Wiki entry for SELL (L-selectin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SELL gene promoter:
         GR   STAT3   PPAR-gamma2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSELL promoter sequence
   Search SABiosciences Chromatin IP Primers for SELL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SELL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23-q25   Ensembl cytogenetic band:  1q24.2   HGNC cytogenetic band: 1q23-q25

SELL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SELL gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M169659:  view genomic region     (about GC identifiers)

Start:
169,659,806 bp from pter      End:
169,680,843 bp from pter
Size:
21,038 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for SELL

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LYAM1_HUMAN, P14151 (See protein sequence)
Recommended Name: L-selectin precursor  
Size: 372 amino acids; 42187 Da
Subunit: Interaction with PSGL1/SELPLG and PODXL2 is required for promoting recruitment and rolling of leukocytes.
This interaction is dependent on the sialyl Lewis X glycan modification of PSGL1 and PODXL2, and tyrosine
sulfation modifications of PSGL1. Sulfation on 'Tyr-51' of PSGL1 is important for L-selectin binding
Subcellular location: Membrane; Single-pass type I membrane protein
Sequence caution: Sequence=CAA34203.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAB43536.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAB43537.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for SELL:
1KJB (3D)        2LGF (3D)        3CFW (3D)    
Secondary accessions: B2R6Q8 P15023 Q9UJ43
Alternative splicing: 2 isoforms:  P14151-1   P14151-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SELL: NX_P14151

Explore proteomics data for SELL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P14151

  • SELL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SELL Protein Expression
    REFSEQ proteins: NP_000646.2  
    ENSEMBL proteins: 
     ENSP00000236147  
    Reactome Protein details: P14151
    Human Recombinant Protein Products for SELL: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for SELL (L-Selectin/CD62L)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SELL
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SELL
    GenScript Custom Purified and Recombinant Proteins Services for SELL
    Novus Biologicals SELL Proteins
    Novus Biologicals SELL Lysates
    Sino Biological Recombinant Protein for SELL
    Sino Biological Cell Lysate for SELL 
    ProSpec Recombinant Protein for SELL
    Cloud-Clone Corp. Proteins for SELL 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS1692315
    GO:0009897external side of plasma membrane IEA--

    SELL for ontologies           About GeneDecksing



    SELL Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SELL
    R&D Systems Antibodies for SELL (L-Selectin/CD62L)
    Browse OriGene Antibodies
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    GenScript Custom Superior Antibodies Services for SELL
    Novus Biologicals SELL Antibodies
    Abcam antibodies for SELL
    Cloud-Clone Corp. Antibodies for SELL 
    ThermoFisher Antibodies for SELL
    LSBio Antibodies in human, mouse, rat for SELL 

    Assay Products for SELL: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SELL
    R&D Systems ELISAs for SELL (L-Selectin/CD62L)         (see all)
    GenScript Custom Assay Services for SELL
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SELL 
    Cloud-Clone Corp. CLIAs for SELL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    5/9 InterPro protein domains (see all 9):
     IPR016187 C-type_lectin_fold
     IPR002396 Selectin_superfamily
     IPR000742 EG-like_dom
     IPR018378 C-type_lectin_CS
     IPR016186 C-type_lectin-like

    Graphical View of Domain Structure for InterPro Entry P14151

    ProtoNet protein and cluster: P14151

    3 Blocks protein domains:
    IPB000436 Sushi domain/SCR domain/CCP module
    IPB002396 Selectin superfamily complement-binding repeat signature
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: LYAM1_HUMAN, P14151
    Similarity: Belongs to the selectin/LECAM family
    Similarity: Contains 1 C-type lectin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 2 Sushi (CCP/SCR) domains


    SELL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LYAM1_HUMAN, P14151
    Function: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high
    endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia

         Genatlas biochemistry entry for SELL:
    L selectin,leukocyte adhesion molecule,74kDa,constitutively expressed on monocytes,thymocytes,NK
    cells,granulocytes,lymph node homing receptor,binding to MCAM1,CD34

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI17548643
    GO:0005515protein binding IPI18606703
    GO:0008201heparin binding TAS7680663
    GO:0030246carbohydrate binding IEA--
    GO:0043208glycosphingolipid binding TAS7680663
         
    SELL for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SELL:
     Increased gamma-H2AX phosphory 

         11 MGI mutant phenotypes (inferred from 12 alleles(MGI details for Sell):
     cardiovascular system  cellular  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  respiratory system 
     tumorigenesis 

    SELL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SELL: Selltm3Tft Selltm1Hyn Selltm4Hyn Selltm2Alb Selltm1Pest Selltm2Hyn
                                                         Selltm1Tft Selltm1Alb Selltm1Flv Selltm3Hyn

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SELL 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SELL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SELL 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SELL 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SELL
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SELL
    SwitchGear 3'UTR luciferase reporter plasmidSELL 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SELL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SELL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SELL
    Sirion Biotech Customized adenovirus for overexpression of SELL

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SELL (NM_000655)
    Sino Biological Human cDNA Clone for SELL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SELL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELL
    Sirion Biotech Customized lentivirus for stable overexpression of SELL 
                         Customized lentivirus expression plasmids for stable overexpression of SELL 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SELL
    Search LifeMap BioReagents cell lines for SELL
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELL


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SELL About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Adaptive Immune System0.56
    2Cell adhesion Cell-matrix glycoconjugates
    Cell adhesion Cell-matrix glycoconjugates0.97
    3Platelet activation, signaling and aggregation
    Hemostasis0.43
    4Classical antibody-mediated complement activation
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30
    5Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for SELL
        Cell adhesion Cell-matrix glycoconjugates


    1 GeneGo (Thomson Reuters) Pathway for SELL
        Cell adhesion Cell-matrix glycoconjugates


    5        Reactome Pathways for SELL
        Hemostasis
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Adaptive Immune System
    Cell surface interactions at the vascular wall
    Immune System


    1         Kegg Pathway  (Kegg details for SELL):
        Cell adhesion molecules (CAMs)


    SELL for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SELL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/20 Interacting proteins for SELL (P141513 ENSP000002361474) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EZRP153113, ENSP000003389344I2D: score=2 STRING: ENSP00000338934
    EMCNQ9ULC03, ENSP000002964204I2D: score=1 STRING: ENSP00000296420
    MUC7Q8TAX73, ENSP000003020214I2D: score=1 STRING: ENSP00000302021
    SELEP165813, ENSP000003317364I2D: score=1 STRING: ENSP00000331736
    SELPLGQ142423, ENSP000003736144I2D: score=1 STRING: ENSP00000373614
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007596blood coagulation TAS--
    GO:0033198response to ATP IEA--
    GO:0050776regulation of immune response TAS--
    GO:0050900leukocyte migration TAS--

    SELL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SELL for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SELL (LYAM1)

    1 HMDB Compound for SELL    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-37534512

    10/94 Novoseek inferred chemical compound relationships for SELL gene (see all 94)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    slex 82.9 48 11053118 (4), 7473003 (3), 1716182 (3), 11017914 (2) (see all 32)
    ppme 81.8 12 7556772 (2), 1709244 (1), 1712791 (1), 9763619 (1) (see all 6)
    fmlp 75.2 66 1709192 (3), 7515857 (2), 7517990 (2), 14699606 (2) (see all 42)
    fucoidan 71.5 36 7556772 (2), 15609279 (2), 1712791 (1), 7532138 (1) (see all 19)
    n-formylmethionyl-leucylphenylalanine 70 21 7513653 (2), 9544581 (1), 8656052 (1), 10625005 (1) (see all 17)
    slea 54.8 4 9430509 (2), 1281614 (1), 7561686 (1)
    sialic acid 50.4 13 8547663 (2), 9400621 (2), 11217952 (1), 8893560 (1) (see all 9)
    cuprophan 49.3 8 9890318 (3), 11721441 (1), 9002533 (1), 7503138 (1) (see all 5)
    tyrosine sulfate 48.8 1 9414280 (1)
    polylactosamine 46.3 4 9184825 (2), 10725346 (1), 11095659 (1)

    Search CenterWatch for drugs/clinical trials and news about SELL / LYAM1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SELL gene: 
    NM_000655.4  

    Unigene Cluster for SELL:

    Selectin L
    Hs.728756  [show with all ESTs]
    Unigene Representative Sequence: NM_000655
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000236147(uc010pls.2 uc001ggk.3) ENST00000497295 ENST00000463108(uc001ggl.2)
    ENST00000460650 ENST00000479657 ENST00000466340
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SELL
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    Inhib. RNA
    Products:
         
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELL
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SELL

    Additional mRNA sequence: 

    AJ246000.1 AK225713.1 AK298705.1 AK312673.1 AY367061.1 BC020758.1 M25280.1 NR_029467.1 
    X16070.1 X16150.1 X17519.1 

    11 DOTS entries:

    DT.315776  DT.100777337  DT.100696868  DT.100746103  DT.121415857  DT.315777  DT.100777339  DT.121415772 
    DT.121415774  DT.91679424  DT.95147243 

    24/150 AceView cDNA sequences (see all 150):

    AI434565 BM477130 BP346240 BC020758 BM972403 AW083158 AJ246000 CB153195 
    AA355761 BQ003754 BX339329 AY367061 CA411781 BF902611 AW440912 AV654869 
    AI026163 NM_000655 AI253539 AI572987 AW474651 H69773 X16150 BG541944 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SELL expression in normal human tissues (normalized intensities)      SELL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAATTTTGCA
    SELL Expression
    About this image


    SELL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 16 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Peripheral blood Pan-T Cells   
     
     Lymph (Hematopoietic System)    fully expand to see all 5 entries
             Regulatory T lymphocytes
             lymph node ; non-germinal center cells   
             Lymphnode   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
             Cord Blood Pan-T Cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; non-germinal center cells   
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus

    See SELL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SELL

    SOURCE GeneReport for Unigene cluster: Hs.728756

    UniProtKB/Swiss-Prot: LYAM1_HUMAN, P14151
    Tissue specificity: Expressed in B-cell lines and T-lymphocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including SELL (see all 6): 
              HIV Host Response in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Atherosclerosis in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SELL
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SELL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SELL gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sell1 , 5 selectin, lymphocyte1, 5 79.66(n)1
    76.08(a)1
      1 (71.37 cM)5
    203431  NM_011346.21  NP_035476.11 
     1640620765 
    zebrafish
    (Danio rerio)
    Actinopterygii sele6
    selp6
    selectin P
    19(a)
    18(a)
    1 ↔ 1
    possible ortholog
    20(33994038-34001545)
    20(33973250-33990756)


    ENSEMBL Gene Tree for SELL (if available)
    TreeFam Gene Tree for SELL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SELL gene
    2 SIMAP similar genes for SELL using alignment to 2 protein entries:     LYAM1_HUMAN (see all proteins):
    SELE    SELP

    SELL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/623 SNPs in SELL are shown (see all 623)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1113052991,2
    C--140884731(+) AAAAA-/AGGCTC 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs1121664711,2
    C--140890035(+) TAAAT-/TCTCTCT 2 -- int11Minor allele frequency- TC:0.50CSA 2
    rs2021281161,2
    C--140894940(+) AAAAG-/AAAAAA 2 -- int10--------
    rs1135981681,2
    C,F--169661542(+) TGCCAG/CCACAC 2 -- int11Minor allele frequency- C:0.50CSA 2
    rs761826811,2
    C--169662309(+) AACTT-/A/AA  
            
    AAAAA
    2 -- int10--------
    rs721179221,2
    C--169666370(+) TTTTT-/TTTTTT 2 -- int11Minor allele frequency- T:0.00CSA 2
    rs574978781,2
    C--169671454(+) GGTAT-/AAAAAAA 2 -- int10--------
    rs2008788141,2
    C--169673156(+) AAAAA-/ACCTAC 2 -- int10--------
    rs49873111,2
    C,F--169673545(-) TTTTTT/-GAAAA 2 -- int12Minor allele frequency- -:0.02NS 94
    rs590953791,2
    C--169674727(+) TTATCT/-TTTTT 2 -- int11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for SELL (169659806 - 169680843 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SELL:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv872539CNV Loss21882294
    nsv872541CNV Loss21882294
    nsv872540CNV Loss21882294
    nsv819234CNV Gain19587683


    Human Gene Mutation Database (HGMD): SELL
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SELL
    DNA2.0 Custom Variant and Variant Library Synthesis for SELL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 153240   
    OMIM disorders: 161950  
    20/133 diseases for SELL (see all 133):    About MalaCards
    cryptococcosis    arthus reaction    kawasaki disease    granulocytopenia
    hyper ige syndrome    bronchopulmonary dysplasia    q fever    sickle cell disease
    venous insufficiency    lymphopenia    common variable immunodeficiency    endotheliitis
    behcet's disease    brucellosis    ureteral obstruction    gastrointestinal system disease
    primary effusion lymphoma    vasculitis    obstructive jaundice    alcoholic hepatitis

    1 disease from the University of Copenhagen DISEASES database for SELL:
    Vascular disease

    SELL for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/94 Novoseek inferred disease relationships for SELL gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 69.8 141 19303986 (3), 8614468 (2), 16740600 (2), 19889515 (2) (see all 99)
    leukocyte adhesion deficiency syndrome 58.5 1 10419878 (1)
    necrosis 51.5 63 8546574 (2), 7527508 (1), 8813119 (1), 9844766 (1) (see all 55)
    lymphocytic leukemia chronic b-cell 45.1 4 7520409 (1), 7690438 (1)
    systemic inflammatory response syndrome 43.8 7 8546574 (1), 8911253 (1), 10966248 (1), 8959352 (1)
    lymphopenia 34.7 1 15039250 (1)
    leukocytosis 34.1 1 9865459 (1)
    sepsis 33.2 36 11176170 (4), 19011162 (2), 9161833 (2), 9517615 (2) (see all 22)
    cryptococcosis disseminated 29.4 3 15776384 (2)
    rheumatoid arthritis 27 10 7543837 (1), 8961381 (1), 9133922 (1), 8857959 (1) (see all 9)

    Genetic Association Database (GAD): SELL
    Human Genome Epidemiology (HuGE) Navigator: SELL (45 documents)

    Export disorders for SELL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SELL gene, integrated from 9 sources (see all 1370):
    (articles sorted by number of sources associating them with SELL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains. (PubMed id 2664786)1, 2, 3 Siegelman M.H. and Weissman I.L. (1989)
    2. Structure of the gene encoding the human leukocyte adhesion molecule- 1 (TQ1, Leu-8) of lymphocytes and neutrophils. (PubMed id 1692315)1, 2, 9 Ord D.C....Tedder T.F. (1990)
    3. Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin. (PubMed id 12736247)1, 2, 9 Leppaenen A.... Cummings R.D. (2003)
    4. Polymorphism in L-selectin, E-selectin and ICAM-1 genes in Asian Indian pediatric patients with celiac disease. (PubMed id 16916660)1, 4, 9 Kaur G....Mehra N.K. (2006)
    5. Leukocyte-endothelial cell adhesion molecule 1 (LECAM-1) polymorphism is associated with diabetic nephropathy in type 2 diabetes mellitus. (PubMed id 12200076)1, 4, 9 Kamiuchi K....Nakamura N. (2002)
    6. Genetic polymorphisms of adhesion molecules and kidne y transplant survival. (PubMed id 20220571)1, 4, 9 Heinold A....Tran T.H. (2010)
    7. Polymorphism in ICAM-1, PECAM-1, E-selectin, and L-selectin genes in Tunisian patients with inflammatory bowel disease. (PubMed id 19212205)1, 4, 9 Khazen D....Ayed K. (2009)
    8. Selectin polymorphisms and perinatal morbidity in low-birthweight infants. (PubMed id 16982492)1, 4, 9 Derzbach L....Rigo J. (2006)
    9. Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen. (PubMed id 12871600)1, 4, 9 Adams G.T....Kutlar A. (2003)
    10. L-selectin gene T668C mutation in type 1 diabetes patients and their first degree relatives. (PubMed id 11064106)1, 4, 9 Kretowski A. and Kinalska I. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6402 HGNC: 10720 AceView: SELL Ensembl:ENSG00000188404 euGenes: HUgn6402
    ECgene: SELL Kegg: 6402 H-InvDB: SELL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SELL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SELL Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/sell/
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_234

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SELL gene:
    Search GeneIP for patents involving SELL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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     Regulatory tfbs in SELL promoter
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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