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Aliases for SELL Gene

Aliases for SELL Gene

  • Selectin L 2 3 5
  • Leukocyte-Endothelial Cell Adhesion Molecule 1 3 4
  • CD62 Antigen-Like Family Member L 3 4
  • Leukocyte Surface Antigen Leu-8 3 4
  • Lymphocyte Adhesion Molecule 1 2 3
  • Lymph Node Homing Receptor 3 4
  • Gp90-MEL 3 4
  • LECAM1 3 4
  • LYAM1 3 4
  • LNHR 3 4
  • TQ1 3 4
  • Leukocyte Adhesion Molecule 1 4
  • Pln Homing Receptor 3
  • CD62L Antigen 4
  • L-Selectin 3
  • CD62L 3
  • PLNHR 3
  • LAM-1 4
  • LAM1 3
  • LEU8 3
  • LSEL 3

External Ids for SELL Gene

Previous HGNC Symbols for SELL Gene

  • LYAM1
  • LNHR

Previous GeneCards Identifiers for SELL Gene

  • GC01M167288
  • GC01M165310
  • GC01M166180
  • GC01M166672
  • GC01M166847
  • GC01M166391
  • GC01M167926
  • GC01M140882

Summaries for SELL Gene

Entrez Gene Summary for SELL Gene

  • This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]

GeneCards Summary for SELL Gene

SELL (Selectin L) is a Protein Coding gene. Diseases associated with SELL include Arthus Reaction and Cryptococcosis. Among its related pathways are Cell adhesion_Cell-matrix glycoconjugates and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. GO annotations related to this gene include carbohydrate binding and protease binding. An important paralog of this gene is SELP.

UniProtKB/Swiss-Prot for SELL Gene

  • Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.

Gene Wiki entry for SELL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELL Gene

Genomics for SELL Gene

Regulatory Elements for SELL Gene

Enhancers for SELL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F169688 1.4 FANTOM5 Ensembl ENCODE 10 +14.7 14652 17.5 YBX3 CTCF PKNOX1 ZNF146 EBF1 RAD21 ZNF316 GATA3 POLR2A EED METTL18 C1orf112 SELP F5 DPT SELL SCYL3 KIFAP3 ENSG00000230704 METTL11B
GH01F169666 0.9 Ensembl ENCODE 10 +43.8 43802 2.2 YBX3 MAFG ZNF316 ZNF512 NBN IRF1 NFE2 EMSY METTL18 SELP DPT SELL C1orf112
GH01F169600 1.2 Ensembl ENCODE 6.8 +107.7 107671 6.3 ARID4B DMAP1 YY1 SP5 MIER2 REST PPARG KAT8 NFIL3 MIER3 SELP C1orf112 METTL18 SELE F5 SELL
GH01F169679 0.9 Ensembl ENCODE 5.6 +30.6 30556 2.8 TBL1XR1 WRNIP1 CBX2 JUNB EBF1 RELA POLR2A NBN METTL18 SELP SELL C1orf112
GH01F169610 0.6 Ensembl 8.4 +100.6 100614 0.4 IRF9 ATF3 HLF ETV1 CEBPB TRIM24 EP300 METTL18 F5 C1orf112 SELL SELP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SELL on UCSC Golden Path with GeneCards custom track

Promoters for SELL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001587748 1802 5001 HDGF ELF3 TBP PKNOX1 NFXL1 YBX1 GLI4 ZNF2 RAD21 ZNF366

Genomic Location for SELL Gene

Chromosome:
1
Start:
169,690,665 bp from pter
End:
169,711,702 bp from pter
Size:
21,038 bases
Orientation:
Minus strand

Genomic View for SELL Gene

Genes around SELL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELL Gene

Proteins for SELL Gene

  • Protein details for SELL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14151-LYAM1_HUMAN
    Recommended name:
    L-selectin
    Protein Accession:
    P14151
    Secondary Accessions:
    • B2R6Q8
    • P15023
    • Q9UJ43

    Protein attributes for SELL Gene

    Size:
    372 amino acids
    Molecular mass:
    42187 Da
    Quaternary structure:
    • Interaction with PSGL1/SELPLG and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of PSGL1 and PODXL2, and tyrosine sulfation modifications of PSGL1. Sulfation on Tyr-51 of PSGL1 is important for L-selectin binding.
    SequenceCaution:
    • Sequence=CAA34203.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAB43536.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAB43537.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SELL Gene

    Alternative splice isoforms for SELL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SELL Gene

Post-translational modifications for SELL Gene

  • Ubiquitination at Lys 78, Lys 93, Lys 134, Lys 137, and Lys 141
  • Glycosylation at Asn 60, Asn 104, Asn 177, Asn 232, Asn 246, and Asn 271
  • Modification sites at PhosphoSitePlus

Other Protein References for SELL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SELL Gene

Domains & Families for SELL Gene

Suggested Antigen Peptide Sequences for SELL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P14151

UniProtKB/Swiss-Prot:

LYAM1_HUMAN :
  • Contains 1 C-type lectin domain.
  • Belongs to the selectin/LECAM family.
Domain:
  • Contains 1 C-type lectin domain.
  • Contains 1 EGF-like domain.
  • Contains 2 Sushi (CCP/SCR) domains.
Family:
  • Belongs to the selectin/LECAM family.
genes like me logo Genes that share domains with SELL: view

Function for SELL Gene

Molecular function for SELL Gene

GENATLAS Biochemistry:
L selectin,leukocyte adhesion molecule,74kDa,constitutively expressed on monocytes,thymocytes,NK cells,granulocytes,lymph node homing receptor,binding to MCAM1,CD34
UniProtKB/Swiss-Prot Function:
Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.

Gene Ontology (GO) - Molecular Function for SELL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 17548643
GO:0005515 protein binding IPI 18606703
GO:0008201 heparin binding TAS 7680663
GO:0030246 carbohydrate binding IEA --
GO:0043208 glycosphingolipid binding TAS 7680663
genes like me logo Genes that share ontologies with SELL: view
genes like me logo Genes that share phenotypes with SELL: view

Animal Models for SELL Gene

MGI Knock Outs for SELL:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SELL Gene

Localization for SELL Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELL Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELL gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
cytosol 2
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SELL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS 1692315
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SELL: view

Pathways & Interactions for SELL Gene

genes like me logo Genes that share pathways with SELL: view

Gene Ontology (GO) - Biological Process for SELL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0033198 response to ATP IEA --
GO:0050776 regulation of immune response TAS --
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with SELL: view

No data available for SIGNOR curated interactions for SELL Gene

Drugs & Compounds for SELL Gene

(48) Drugs for SELL Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bimosiamose Pharma inhibitor 0
GMI-1070 Pharma 0
SMART ANTI-L-SELECTIN Pharma 0

(50) Additional Compounds for SELL Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-O-Sulfogalactosylceramide (d18:1/24:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • 3-O-Sulphogalactosylceramide
151122-71-3
genes like me logo Genes that share compounds with SELL: view

Transcripts for SELL Gene

Unigene Clusters for SELL Gene

Selectin L:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELL Gene

No ASD Table

Relevant External Links for SELL Gene

GeneLoc Exon Structure for
SELL
ECgene alternative splicing isoforms for
SELL

Expression for SELL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SELL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SELL Gene

This gene is overexpressed in Whole Blood (x48.5).

Protein differential expression in normal tissues from HIPED for SELL Gene

This gene is overexpressed in Serum (42.7) and Plasma (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SELL Gene



NURSA nuclear receptor signaling pathways regulating expression of SELL Gene:

SELL

SOURCE GeneReport for Unigene cluster for SELL Gene:

Hs.728756

mRNA Expression by UniProt/SwissProt for SELL Gene:

P14151-LYAM1_HUMAN
Tissue specificity: Expressed in B-cell lines and T-lymphocytes.
genes like me logo Genes that share expression patterns with SELL: view

Primer Products

No data available for Protein tissue co-expression partners for SELL Gene

Orthologs for SELL Gene

This gene was present in the common ancestor of animals.

Orthologs for SELL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SELL 34 35
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia SELL 34 35
  • 84.41 (n)
cow
(Bos Taurus)
Mammalia SELL 34 35
  • 84.11 (n)
rat
(Rattus norvegicus)
Mammalia Sell 34
  • 80.47 (n)
mouse
(Mus musculus)
Mammalia Sell 34 16 35
  • 79.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SELL 35
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SELL 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sele 34
  • 59.85 (n)
zebrafish
(Danio rerio)
Actinopterygii selp 35
  • 19 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta hig 35
  • 6 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lev-9 35
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10017 35
  • 8 (a)
ManyToMany
-- 35
  • 5 (a)
ManyToMany
-- 35
  • 4 (a)
ManyToMany
-- 35
  • 4 (a)
ManyToMany
-- 35
  • 4 (a)
ManyToMany
CSA.10029 35
  • 3 (a)
ManyToMany
Species where no ortholog for SELL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SELL Gene

ENSEMBL:
Gene Tree for SELL (if available)
TreeFam:
Gene Tree for SELL (if available)

Paralogs for SELL Gene

(2) SIMAP similar genes for SELL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SELL: view

Variants for SELL Gene

Sequence variations from dbSNP and Humsavar for SELL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1051091 -- 169,708,568(-) TCTCT(C/T)ACTGA nc-transcript-variant, reference, synonymous-codon
rs10919222 -- 169,692,250(+) ATTTA(A/T)TTATT intron-variant
rs10919223 -- 169,698,829(+) GTGCT(C/G)TCATG intron-variant
rs111305299 -- 169,693,182(+) AAAAA(-/A)GGCTC intron-variant
rs111401273 -- 169,702,082(+) CTGAA(C/G)TGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SELL Gene

Variant ID Type Subtype PubMed ID
nsv952232 CNV duplication 24416366
nsv819234 CNV gain 19587683
nsv1078878 OTHER inversion 25765185
nsv1009313 CNV loss 25217958

Variation tolerance for SELL Gene

Residual Variation Intolerance Score: 53.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.83; 93.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELL Gene

Human Gene Mutation Database (HGMD)
SELL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELL Gene

Disorders for SELL Gene

MalaCards: The human disease database

(30) MalaCards diseases for SELL Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
arthus reaction
  • arthus phenomenon
cryptococcosis
  • busse-buschke's disease
granulocytopenia
  • agranulocytosis
colon mucinous adenocarcinoma
  • colonic mucinous adenocarcinoma
lymphopenia
  • lymphocytopenia
- elite association - COSMIC cancer census association via MalaCards
Search SELL in MalaCards View complete list of genes associated with diseases

Relevant External Links for SELL

Genetic Association Database (GAD)
SELL
Human Genome Epidemiology (HuGE) Navigator
SELL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELL
genes like me logo Genes that share disorders with SELL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SELL Gene

Publications for SELL Gene

  1. Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin. (PMID: 12736247) Leppaenen A. … Cummings R.D. (J. Biol. Chem. 2003) 3 4 22 64
  2. Structure of the gene encoding the human leukocyte adhesion molecule- 1 (TQ1, Leu-8) of lymphocytes and neutrophils. (PMID: 1692315) Ord D.C. … Tedder T.F. (J. Biol. Chem. 1990) 3 4 22 64
  3. Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains. (PMID: 2664786) Siegelman M.H. … Weissman I.L. (Proc. Natl. Acad. Sci. U.S.A. 1989) 2 3 4 64
  4. Genetic polymorphisms of adhesion molecules and kidney transplant survival. (PMID: 20220571) Heinold A. … Tran T.H. (Transplantation 2010) 3 46 64
  5. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PMID: 20485444) Wang Y. … Huang W. (J. Hum. Genet. 2010) 3 46 64

Products for SELL Gene

Sources for SELL Gene

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