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Aliases for SELL Gene

Aliases for SELL Gene

  • Selectin L 2 3
  • LYAM1 3 4 6
  • LNHR 3 4 6
  • Leukocyte-Endothelial Cell Adhesion Molecule 1 3 4
  • CD62 Antigen-Like Family Member L 3 4
  • Leukocyte Surface Antigen Leu-8 3 4
  • Lymphocyte Adhesion Molecule 1 2 3
  • Lymph Node Homing Receptor 3 4
  • Gp90-MEL 3 4
  • LECAM1 3 4
  • LAM1 3 6
  • TQ1 3 4
  • Leukocyte Adhesion Molecule 1 4
  • Pln Homing Receptor 3
  • CD62L Antigen 4
  • L-Selectin 3
  • CD62L 3
  • PLNHR 3
  • LAM-1 4
  • LEU8 3
  • LSEL 3

External Ids for SELL Gene

Previous Symbols for SELL Gene

  • LYAM1
  • LNHR

Summaries for SELL Gene

Entrez Gene Summary for SELL Gene

  • This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]

GeneCards Summary for SELL Gene

SELL (Selectin L) is a Protein Coding gene. Diseases associated with SELL include arthus reaction and cryptococcosis. Among its related pathways are Class I MHC mediated antigen processing and presentation and Hemostasis. GO annotations related to this gene include carbohydrate binding and protease binding. An important paralog of this gene is CSMD3.

UniProtKB/Swiss-Prot for SELL Gene

  • Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.

Gene Wiki entry for SELL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELL Gene

Genomics for SELL Gene

Genomic Location for SELL Gene

Start:
169,690,665 bp from pter
End:
169,711,702 bp from pter
Size:
21,038 bases
Orientation:
Minus strand

Genomic View for SELL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SELL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELL Gene

Regulatory Elements for SELL Gene

Proteins for SELL Gene

  • Protein details for SELL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14151-LYAM1_HUMAN
    Recommended name:
    L-selectin
    Protein Accession:
    P14151
    Secondary Accessions:
    • B2R6Q8
    • P15023
    • Q9UJ43

    Protein attributes for SELL Gene

    Size:
    372 amino acids
    Molecular mass:
    42187 Da
    Quaternary structure:
    • Interaction with PSGL1/SELPLG and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of PSGL1 and PODXL2, and tyrosine sulfation modifications of PSGL1. Sulfation on Tyr-51 of PSGL1 is important for L-selectin binding
    SequenceCaution:
    • Sequence=CAA34203.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAB43536.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAB43537.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SELL Gene

    Alternative splice isoforms for SELL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SELL Gene

Proteomics data for SELL Gene at MOPED

Post-translational modifications for SELL Gene

  • Ubiquitination at Lys78, Lys93, Lys134, Lys137, and Lys141
  • Glycosylation at Asn60, Asn104, Asn177, Asn232, Asn246, and Asn271

Other Protein References for SELL Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SELL Gene

Domains for SELL Gene

Gene Families for SELL Gene

HGNC:
  • CD :CD molecules

UniProtKB/Swiss-Prot:

LYAM1_HUMAN
Domain:
  • Contains 1 C-type lectin domain.:
    • P14151
  • Contains 1 EGF-like domain.:
    • P14151
  • Contains 2 Sushi (CCP/SCR) domains.:
    • P14151
Family:
  • Belongs to the selectin/LECAM family.:
    • P14151
genes like me logo Genes that share domains with SELL: view

Function for SELL Gene

Molecular function for SELL Gene

GENATLAS Biochemistry: L selectin,leukocyte adhesion molecule,74kDa,constitutively expressed on monocytes,thymocytes,NK cells,granulocytes,lymph node homing receptor,binding to MCAM1,CD34
UniProtKB/Swiss-Prot Function: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.

Gene Ontology (GO) - Molecular Function for SELL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 17548643
GO:0005515 protein binding IPI 18606703
GO:0008201 heparin binding TAS 7680663
GO:0030246 carbohydrate binding IEA --
GO:0043208 glycosphingolipid binding TAS 7680663
genes like me logo Genes that share ontologies with SELL: view
genes like me logo Genes that share phenotypes with SELL: view

Animal Models for SELL Gene

MGI Knock Outs for SELL:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SELL Gene

Localization for SELL Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELL Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SELL Gene COMPARTMENTS Subcellular localization image for SELL gene
Compartment Confidence
plasma membrane 4
cytoskeleton 2
extracellular 2

Gene Ontology (GO) - Cellular Components for SELL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1692315
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface --
genes like me logo Genes that share ontologies with SELL: view

Pathways for SELL Gene

genes like me logo Genes that share pathways with SELL: view

Pathways by source for SELL Gene

Gene Ontology (GO) - Biological Process for SELL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007596 blood coagulation TAS --
GO:0033198 response to ATP IEA --
GO:0050776 regulation of immune response TAS --
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with SELL: view

Compounds for SELL Gene

(1) HMDB Compounds for SELL Gene

Compound Synonyms Cas Number PubMed IDs
3-O-Sulfogalactosylceramide (d18:1/24:0)
  • Sulfatide (d18:1/24:0)
151122-71-3

(94) Novoseek inferred chemical compound relationships for SELL Gene

Compound -log(P) Hits PubMed IDs
slex 82.9 44
ppme 81.8 7
fmlp 75.2 51
fucoidan 71.5 21
n-formylmethionyl-leucylphenylalanine 70 18
genes like me logo Genes that share compounds with SELL: view

Transcripts for SELL Gene

Unigene Clusters for SELL Gene

Selectin L:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SELL Gene

No ASD Table

Relevant External Links for SELL Gene

GeneLoc Exon Structure for
SELL
ECgene alternative splicing isoforms for
SELL

Expression for SELL Gene

mRNA expression in normal human tissues for SELL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SELL Gene

This gene is overexpressed in Whole Blood (48.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SELL Gene

SOURCE GeneReport for Unigene cluster for SELL Gene Hs.728756

mRNA Expression by UniProt/SwissProt for SELL Gene

P14151-LYAM1_HUMAN
Tissue specificity: Expressed in B-cell lines and T-lymphocytes.
genes like me logo Genes that share expressions with SELL: view

Orthologs for SELL Gene

This gene was present in the common ancestor of animals.

Orthologs for SELL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SELL 36
  • 99.46 (n)
  • 99.73 (a)
SELL 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SELL 36
  • 84.11 (n)
  • 78.24 (a)
SELL 37
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SELL 36
  • 84.41 (n)
  • 81.99 (a)
SELL 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sell 36
  • 79.66 (n)
  • 76.08 (a)
Sell 16
Sell 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SELL 37
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SELL 37
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sell 36
  • 80.47 (n)
  • 77.42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sele 36
  • 59.85 (n)
  • 57.76 (a)
zebrafish
(Danio rerio)
Actinopterygii selp 37
  • 19 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta hig 37
  • 6 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lev-9 37
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 4 (a)
ManyToMany
-- 37
  • 5 (a)
ManyToMany
-- 37
  • 4 (a)
ManyToMany
-- 37
  • 4 (a)
ManyToMany
CSA.10017 37
  • 8 (a)
ManyToMany
CSA.10029 37
  • 3 (a)
ManyToMany
Species with no ortholog for SELL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SELL Gene

ENSEMBL:
Gene Tree for SELL (if available)
TreeFam:
Gene Tree for SELL (if available)

Paralogs for SELL Gene

Paralogs for SELL Gene

Selected SIMAP similar genes for SELL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SELL: view

Variants for SELL Gene

Sequence variations from dbSNP and Humsavar for SELL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7553 -- 169,690,861(-) CCAGA(A/C)CTTTT utr-variant-3-prime, nc-transcript-variant
rs12938 -- 169,691,640(-) CTACC(C/T)GACCA utr-variant-3-prime, nc-transcript-variant
rs909628 -- 169,691,524(+) CCTTT(A/G)TGGTC utr-variant-3-prime, nc-transcript-variant
rs964555 -- 169,701,947(+) AATGC(A/C)CCTAA intron-variant
rs964556 -- 169,701,976(+) TCATC(A/G)TTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SELL Gene

Variant ID Type Subtype PubMed ID
nsv872539 CNV Loss 21882294
nsv819234 CNV Gain 19587683
nsv872540 CNV Loss 21882294
nsv872541 CNV Loss 21882294

Relevant External Links for SELL Gene

HapMap Linkage Disequilibrium report
SELL
Human Gene Mutation Database (HGMD)
SELL

Disorders for SELL Gene

(1) University of Copenhagen DISEASES for SELL Gene

(94) Novoseek inferred disease relationships for SELL Gene

Disease -log(P) Hits PubMed IDs
inflammation 69.8 111
leukocyte adhesion deficiency syndrome 58.5 1
necrosis 51.5 56
lymphocytic leukemia chronic b-cell 45.1 2
systemic inflammatory response syndrome 43.8 4

Relevant External Links for SELL

Genetic Association Database (GAD)
SELL
Human Genome Epidemiology (HuGE) Navigator
SELL
genes like me logo Genes that share disorders with SELL: view

No data available for UniProtKB/Swiss-Prot for SELL Gene

Publications for SELL Gene

  1. Structure of the gene encoding the human leukocyte adhesion molecule- 1 (TQ1, Leu-8) of lymphocytes and neutrophils. (PMID: 1692315) Ord D.C. … Tedder T.F. (J. Biol. Chem. 1990) 3 4 23
  2. L-selectin gene T668C mutation in type 1 diabetes patients and their first degree relatives. (PMID: 11064106) Kretowski A. … Kinalska I. (Immunol. Lett. 2000) 3 23 49
  3. Leukocyte-endothelial cell adhesion molecule 1 (LECAM-1) polymorphism is associated with diabetic nephropathy in type 2 diabetes mellitus. (PMID: 12200076) Kamiuchi K. … Nakamura N. (J. Diabetes Complicat. 2002) 3 23 49
  4. Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin. (PMID: 12736247) Leppaenen A. … Cummings R.D. (J. Biol. Chem. 2003) 3 4 23
  5. Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen. (PMID: 12871600) Adams G.T. … Kutlar A. (BMC Med. Genet. 2003) 3 23 49

Products for SELL Gene

Sources for SELL Gene

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