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SELL Gene

protein-coding   GIFtS: 64
GCID: GC01M169659

Selectin L

(Previous name: lymphocyte adhesion molecule 1)
(Previous symbols: LYAM1, LNHR)
  See SELL-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Selectin L1 2     LAM12 5
LNHR1 2 3 5     CD62L2
LYAM11 2 3 5     L-selectin2
Lymphocyte Adhesion Molecule 11 2     LEU82
Leukocyte Surface Antigen Leu-82 3     LSEL2
Leukocyte-Endothelial Cell Adhesion Molecule 12 3     PLNHR2
Lymph Node Homing Receptor2 3     Pln Homing Receptor2
LECAM12 3     LAM-13
TQ12 3     CD62L Antigen3
CD62 Antigen-Like Family Member L2 3     Leukocyte Adhesion Molecule 13
gp90-MEL2 3     

External Ids:    HGNC: 107201   Entrez Gene: 64022   Ensembl: ENSG000001884047   OMIM: 1532405   UniProtKB: P141513   

Export aliases for SELL gene to outside databases

Previous GC identifers: GC01M167288 GC01M165310 GC01M166180 GC01M166672 GC01M166847 GC01M166391 GC01M167926 GC01M140882


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SELL Gene:
This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The
encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and
two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes
on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites.
Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin
A nephropathy. Alternatively spliced transcript variants have been found for this gene. (provided by RefSeq, Oct
2009)

GeneCards Summary for SELL Gene:
SELL (selectin L) is a protein-coding gene. Diseases associated with SELL include cryptococcosis, and arthus reaction. GO annotations related to this gene include carbohydrate binding and protease binding. An important paralog of this gene is CSMD1.

UniProtKB/Swiss-Prot: LYAM1_HUMAN, P14151
Function: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high
endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia

Gene Wiki entry for SELL (L-selectin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SELL gene promoter:
         GR   STAT3   PPAR-gamma2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSELL promoter sequence
   Search Chromatin IP Primers for SELL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SELL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23-q25   Ensembl cytogenetic band:  1q24.2   HGNC cytogenetic band: 1q23-q25

SELL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SELL gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M169659:  view genomic region     (about GC identifiers)

Start:
169,659,806 bp from pter      End:
169,680,843 bp from pter
Size:
21,038 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for SELL

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LYAM1_HUMAN, P14151 (See protein sequence)
Recommended Name: L-selectin precursor  
Size: 372 amino acids; 42187 Da
Subunit: Interaction with PSGL1/SELPLG and PODXL2 is required for promoting recruitment and rolling of leukocytes.
This interaction is dependent on the sialyl Lewis X glycan modification of PSGL1 and PODXL2, and tyrosine
sulfation modifications of PSGL1. Sulfation on 'Tyr-51' of PSGL1 is important for L-selectin binding
Sequence caution: Sequence=CAA34203.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAB43536.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAB43537.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for SELL:
1KJB (3D)        2LGF (3D)        3CFW (3D)    
Secondary accessions: B2R6Q8 P15023 Q9UJ43
Alternative splicing: 2 isoforms:  P14151-1   P14151-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SELL: NX_P14151

Explore proteomics data for SELL at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys78, Lys93, Lys134, Lys137, Lys141
  • Glycosylation2 at Asn60, Asn104, Asn177, Asn232, Asn246, Asn271

  • See SELL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000646.2  
    ENSEMBL proteins: 
     ENSP00000236147  
    Reactome Protein details: P14151

    SELL Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SELL

     
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    SELL Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SELL
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    SELL Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SELL
    Cloud-Clone Corp. CLIAs for SELL
    eBioscience ELISAs for SELL: (see all 4
                        Human sL-selectin Platinum ELISA 96 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    Selected InterPro protein domains (see all 9):
     IPR002396 Selectin_superfamily
     IPR000742 EG-like_dom
     IPR016348 L-selectin
     IPR000436 Sushi_SCR_CCP
     IPR016187 C-type_lectin_fold

    Graphical View of Domain Structure for InterPro Entry P14151

    ProtoNet protein and cluster: P14151

    3 Blocks protein domains:
    IPB000436 Sushi domain/SCR domain/CCP module
    IPB002396 Selectin superfamily complement-binding repeat signature
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: LYAM1_HUMAN, P14151
    Similarity: Belongs to the selectin/LECAM family
    Similarity: Contains 1 C-type lectin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 2 Sushi (CCP/SCR) domains


    Find genes that share domains with SELL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LYAM1_HUMAN, P14151
    Function: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high
    endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia

         Genatlas biochemistry entry for SELL:
    L selectin,leukocyte adhesion molecule,74kDa,constitutively expressed on monocytes,thymocytes,NK
    cells,granulocytes,lymph node homing receptor,binding to MCAM1,CD34

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI17548643
    GO:0005515protein binding IPI18606703
    GO:0008201heparin binding TAS7680663
    GO:0030246carbohydrate binding IEA--
    GO:0043208glycosphingolipid binding TAS7680663
         
    Find genes that share ontologies with SELL           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SELL:
     Increased gamma-H2AX phosphory 

         11 MGI mutant phenotypes (inferred from 12 alleles(MGI details for Sell):
     cardiovascular system  cellular  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  respiratory system 
     tumorigenesis 

    Find genes that share phenotypes with SELL           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SELL: Selltm3Tft Selltm1Hyn Selltm4Hyn Selltm2Alb Selltm1Pest Selltm2Hyn
                                                         Selltm1Tft Selltm1Alb Selltm1Flv Selltm3Hyn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SELL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SELL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SELL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SELL

    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SELL

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SELL (NM_000655)
    Sino Biological Human cDNA Clone for SELL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SELL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELL

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LYAM1_HUMAN, P14151: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton2
    extracellular2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS1692315
    GO:0009897external side of plasma membrane IEA--

    Find genes that share ontologies with SELL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SELL About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Hemostasis
    Hemostasis0.43
    2Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    3Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    4Cell surface interactions at the vascular wall
    Cell surface interactions at the vascular wall
    5Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)


    Find genes that share SuperPaths with SELL           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for SELL
        Cell adhesion Cell-matrix glycoconjugates


    2 Reactome Pathways for SELL
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Cell surface interactions at the vascular wall


    1 Kegg Pathway  (Kegg details for SELL):
        Cell adhesion molecules (CAMs)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SELL (see all 6): 
              HIV Host Response in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Atherosclerosis in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SELL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for SELL (P141513 ENSP000002361474) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EZRP153113, ENSP000003389344I2D: score=2 STRING: ENSP00000338934
    EMCNQ9ULC03, ENSP000002964204I2D: score=1 STRING: ENSP00000296420
    MUC7Q8TAX73, ENSP000003020214I2D: score=1 STRING: ENSP00000302021
    SELEP165813, ENSP000003317364I2D: score=1 STRING: ENSP00000331736
    SELPLGQ142423, ENSP000003736144I2D: score=1 STRING: ENSP00000373614
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007596blood coagulation TAS--
    GO:0033198response to ATP IEA--
    GO:0050776regulation of immune response TAS--
    GO:0050900leukocyte migration TAS--

    Find genes that share ontologies with SELL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SELL (LYAM1)

    1 HMDB Compound for SELL    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-37534512

    Selected Novoseek inferred chemical compound relationships for SELL gene (see all 94)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    slex 82.9 48 11053118 (4), 7473003 (3), 1716182 (3), 11017914 (2) (see all 32)
    ppme 81.8 12 7556772 (2), 1709244 (1), 1712791 (1), 9763619 (1) (see all 6)
    fmlp 75.2 66 1709192 (3), 7515857 (2), 7517990 (2), 14699606 (2) (see all 42)
    fucoidan 71.5 36 7556772 (2), 15609279 (2), 1712791 (1), 7532138 (1) (see all 19)
    n-formylmethionyl-leucylphenylalanine 70 21 7513653 (2), 9544581 (1), 8656052 (1), 10625005 (1) (see all 17)
    slea 54.8 4 9430509 (2), 1281614 (1), 7561686 (1)
    sialic acid 50.4 13 8547663 (2), 9400621 (2), 11217952 (1), 8893560 (1) (see all 9)
    cuprophan 49.3 8 9890318 (3), 11721441 (1), 9002533 (1), 7503138 (1) (see all 5)
    tyrosine sulfate 48.8 1 9414280 (1)
    polylactosamine 46.3 4 9184825 (2), 10725346 (1), 11095659 (1)



    Find genes that share compounds with SELL           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SELL gene: 
    NM_000655.4  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000236147(uc010pls.2 uc001ggk.3) ENST00000497295 ENST00000463108(uc001ggl.2)
    ENST00000460650 ENST00000479657 ENST00000466340
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat SELL

    Selected AceView cDNA sequences (see all 150):

    AW474651 AI434565 AI026163 NM_000655 AA355761 AW440912 BC020758 AV654869 
    AY367061 BX339329 BP346240 BQ003754 AJ246000 CA411781 BM477130 CB153195 
    BF902611 AI253539 AI572987 BM972403 AW083158 CD695377 AA677591 AI434388 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SELL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAATTTTGCA
    SELL Expression
    About this image


    SELL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 5 entries
             Granulocytes Peripheral Blood
     
     Lymph (Hematopoietic System)
             Regulatory T lymphocytes
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    SELL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SELL Protein Expression

    UniProtKB/Swiss-Prot: LYAM1_HUMAN, P14151
    Tissue specificity: Expressed in B-cell lines and T-lymphocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SELL (see all 6): 
              HIV Host Response in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Atherosclerosis in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

    Primer
    Products:
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SELL gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sell1 , 5 selectin, lymphocyte1, 5 79.66(n)1
    76.08(a)1
      1 (71.37 cM)5
    203431  NM_011346.21  NP_035476.11 
     1640620765 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sele1 selectin E 59.85(n)
    57.76(a)
      100498512  XM_002933782.2  XP_002933828.2 
    zebrafish
    (Danio rerio)
    Actinopterygii selp6
    selectin P
    19(a)
    1 → many
    20(33973250-33984423) ENSDARG00000042138
    fruit fly
    (Drosophila melanogaster)
    Insecta hig6
    hikaru genki
    6(a)
    1 → many
    2R(5115286-5134752)
    worm
    (Caenorhabditis elegans)
    Secernentea lev-96
    Protein LEV-9 (lev-9) mRNA, complete cds
    8(a)
    1 → many
    X(6286453-6291732) WBGene00002976


    ENSEMBL Gene Tree for SELL (if available)
    TreeFam Gene Tree for SELL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SELL gene
    CSMD12  SELP2  C4BPA2  CR22  CSMD32  CR1L2  APOH2  SELE2  
    CSMD22  CD462  CD552  CR12  SVEP12  
    2 SIMAP similar genes for SELL using alignment to 2 protein entries:     LYAM1_HUMAN (see all proteins):
    SELE    SELP

    Find genes that share paralogs with SELL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SELL (see all 623)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1113052991,2
    C--140884731(+) AAAAA-/AGGCTC 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs1121664711,2
    C--140890035(+) TAAAT-/TCTCTCT 2 -- int11Minor allele frequency- TC:0.50CSA 2
    rs2021281161,2
    C--140894940(+) AAAAG-/AAAAAA 2 -- int10--------
    rs1135981681,2
    C,F--169661542(+) TGCCAG/CCACAC 2 -- int11Minor allele frequency- C:0.50CSA 2
    rs761826811,2
    C--169662309(+) AACTT-/A/AA  
            
    AAAAA
    2 -- int10--------
    rs721179221,2
    C--169666370(+) TTTTT-/TTTTTT 2 -- int11Minor allele frequency- T:0.00CSA 2
    rs574978781,2
    C--169671454(+) GGTAT-/AAAAAAA 2 -- int10--------
    rs2008788141,2
    C--169673156(+) AAAAA-/ACCTAC 2 -- int10--------
    rs49873111,2
    C,F--169673545(-) TTTTTT/-GAAAA 2 -- int12Minor allele frequency- -:0.02NS 94
    rs590953791,2
    C--169674727(+) TTATCT/-TTTTT 2 -- int11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for SELL (169659806 - 169680843 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SELL:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv872539CNV Loss21882294
    nsv872541CNV Loss21882294
    nsv872540CNV Loss21882294
    nsv819234CNV Gain19587683

    Human Gene Mutation Database (HGMD): SELL
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SELL
    DNA2.0 Custom Variant and Variant Library Synthesis for SELL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 153240    OMIM disorders: --

    9 diseases for SELL:    
    About MalaCards
    cryptococcosis    arthus reaction    granulocytopenia    kawasaki disease
    bronchopulmonary dysplasia    sepsis    sickle cell disease    leukocyte adhesion deficiency
    behcet's disease

    1 disease from the University of Copenhagen DISEASES database for SELL:
    Vascular disease

    Find genes that share disorders with SELL           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SELL gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 69.8 141 19303986 (3), 8614468 (2), 16740600 (2), 19889515 (2) (see all 99)
    leukocyte adhesion deficiency syndrome 58.5 1 10419878 (1)
    necrosis 51.5 63 8546574 (2), 7527508 (1), 8813119 (1), 9844766 (1) (see all 55)
    lymphocytic leukemia chronic b-cell 45.1 4 7520409 (1), 7690438 (1)
    systemic inflammatory response syndrome 43.8 7 8546574 (1), 8911253 (1), 10966248 (1), 8959352 (1)
    lymphopenia 34.7 1 15039250 (1)
    leukocytosis 34.1 1 9865459 (1)
    sepsis 33.2 36 11176170 (4), 19011162 (2), 9161833 (2), 9517615 (2) (see all 22)
    cryptococcosis disseminated 29.4 3 15776384 (2)
    rheumatoid arthritis 27 10 7543837 (1), 8961381 (1), 9133922 (1), 8857959 (1) (see all 9)

    Genetic Association Database (GAD): SELL
    Human Genome Epidemiology (HuGE) Navigator: SELL (45 documents)

    Export disorders for SELL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SELL gene, integrated from 10 sources (see all 1375):
    (articles sorted by number of sources associating them with SELL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains. (PubMed id 2664786)1, 2, 3 Siegelman M.H. and Weissman I.L. (Proc. Natl. Acad. Sci. U.S.A. 1989)
    2. Structure of the gene encoding the human leukocyte adhesion molecule- 1 (TQ1, Leu-8) of lymphocytes and neutrophils. (PubMed id 1692315)1, 2, 9 Ord D.C....Tedder T.F. (J. Biol. Chem. 1990)
    3. Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin. (PubMed id 12736247)1, 2, 9 Leppaenen A.... Cummings R.D. (J. Biol. Chem. 2003)
    4. Polymorphism in L-selectin, E-selectin and ICAM-1 genes in Asian Indian pediatric patients with celiac disease. (PubMed id 16916660)1, 4, 9 Kaur G....Mehra N.K. (Hum. Immunol. 2006)
    5. Leukocyte-endothelial cell adhesion molecule 1 (LECAM-1) polymorphism is associated with diabetic nephropathy in type 2 diabetes mellitus. (PubMed id 12200076)1, 4, 9 Kamiuchi K....Nakamura N. (J. Diabetes Complicat. 2002)
    6. Genetic polymorphisms of adhesion molecules and kidney transplant survival. (PubMed id 20220571)1, 4, 9 Heinold A....Tran T.H. (Transplantation 2010)
    7. Polymorphism in ICAM-1, PECAM-1, E-selectin, and L-selectin genes in Tunisian patients with inflammatory bowel disease. (PubMed id 19212205)1, 4, 9 Khazen D....Ayed K. (amp 2009)
    8. Selectin polymorphisms and perinatal morbidity in low-birthweight infants. (PubMed id 16982492)1, 4, 9 Derzbach L....RigA^ J. (Acta Paediatr. 2006)
    9. Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen. (PubMed id 12871600)1, 4, 9 Adams G.T....Kutlar A. (BMC Med. Genet. 2003)
    10. L-selectin gene T668C mutation in type 1 diabetes patients and their first degree relatives. (PubMed id 11064106)1, 4, 9 Kretowski A. and Kinalska I. (Immunol. Lett. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6402 HGNC: 10720 AceView: SELL Ensembl:ENSG00000188404 euGenes: HUgn6402
    ECgene: SELL Kegg: 6402 H-InvDB: SELL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SELL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SELL Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/sell/
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_234

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SELL gene:
    Search GeneIP for patents involving SELL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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