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Aliases for SELL Gene

Aliases for SELL Gene

  • Selectin L 2 3 5
  • Leukocyte-Endothelial Cell Adhesion Molecule 1 3 4
  • CD62 Antigen-Like Family Member L 3 4
  • Leukocyte Surface Antigen Leu-8 3 4
  • Lymphocyte Adhesion Molecule 1 2 3
  • Lymph Node Homing Receptor 3 4
  • Gp90-MEL 3 4
  • LECAM1 3 4
  • LYAM1 3 4
  • LNHR 3 4
  • TQ1 3 4
  • Leukocyte Adhesion Molecule 1 4
  • Pln Homing Receptor 3
  • CD62L Antigen 4
  • CD62L 3
  • PLNHR 3
  • LAM-1 4
  • LAM1 3
  • LEU8 3
  • LSEL 3

External Ids for SELL Gene

Previous HGNC Symbols for SELL Gene

  • LYAM1
  • LNHR

Previous GeneCards Identifiers for SELL Gene

  • GC01M167288
  • GC01M165310
  • GC01M166180
  • GC01M166672
  • GC01M166847
  • GC01M166391
  • GC01M167926
  • GC01M140882

Summaries for SELL Gene

Entrez Gene Summary for SELL Gene

  • This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]

GeneCards Summary for SELL Gene

SELL (Selectin L) is a Protein Coding gene. Diseases associated with SELL include cryptococcosis and colon mucinous adenocarcinoma. Among its related pathways are Platelet activation, signaling and aggregation and Immune System. GO annotations related to this gene include carbohydrate binding and protease binding. An important paralog of this gene is CSMD3.

UniProtKB/Swiss-Prot for SELL Gene

  • Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.

Gene Wiki entry for SELL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELL Gene

Genomics for SELL Gene

Regulatory Elements for SELL Gene

Promoters for SELL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SELL on UCSC Golden Path with GeneCards custom track

Genomic Location for SELL Gene

Chromosome:
1
Start:
169,690,665 bp from pter
End:
169,711,702 bp from pter
Size:
21,038 bases
Orientation:
Minus strand

Genomic View for SELL Gene

Genes around SELL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELL Gene

Proteins for SELL Gene

  • Protein details for SELL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14151-LYAM1_HUMAN
    Recommended name:
    L-selectin
    Protein Accession:
    P14151
    Secondary Accessions:
    • B2R6Q8
    • P15023
    • Q9UJ43

    Protein attributes for SELL Gene

    Size:
    372 amino acids
    Molecular mass:
    42187 Da
    Quaternary structure:
    • Interaction with PSGL1/SELPLG and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of PSGL1 and PODXL2, and tyrosine sulfation modifications of PSGL1. Sulfation on Tyr-51 of PSGL1 is important for L-selectin binding.
    SequenceCaution:
    • Sequence=CAA34203.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAB43536.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAB43537.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SELL Gene

    Alternative splice isoforms for SELL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SELL Gene

Proteomics data for SELL Gene at MOPED

Post-translational modifications for SELL Gene

  • Ubiquitination at Lys 78, Lys 93, Lys 134, Lys 137, and Lys 141
  • Glycosylation at Asn 60, Asn 104, Asn 177, Asn 232, Asn 246, and Asn 271
  • Modification sites at PhosphoSitePlus

Other Protein References for SELL Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for SELL (L-Selectin/CD62L)

No data available for DME Specific Peptides for SELL Gene

Domains & Families for SELL Gene

Suggested Antigen Peptide Sequences for SELL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P14151

UniProtKB/Swiss-Prot:

LYAM1_HUMAN :
  • Contains 1 C-type lectin domain.
  • Belongs to the selectin/LECAM family.
Domain:
  • Contains 1 C-type lectin domain.
  • Contains 1 EGF-like domain.
  • Contains 2 Sushi (CCP/SCR) domains.
Family:
  • Belongs to the selectin/LECAM family.
genes like me logo Genes that share domains with SELL: view

Function for SELL Gene

Molecular function for SELL Gene

GENATLAS Biochemistry:
L selectin,leukocyte adhesion molecule,74kDa,constitutively expressed on monocytes,thymocytes,NK cells,granulocytes,lymph node homing receptor,binding to MCAM1,CD34
UniProtKB/Swiss-Prot Function:
Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.

Gene Ontology (GO) - Molecular Function for SELL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 17548643
GO:0008201 heparin binding TAS 7680663
genes like me logo Genes that share ontologies with SELL: view
genes like me logo Genes that share phenotypes with SELL: view

Animal Models for SELL Gene

MGI Knock Outs for SELL:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SELL Gene

Localization for SELL Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELL Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SELL Gene COMPARTMENTS Subcellular localization image for SELL gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
cytosol 2
extracellular 2
lysosome 1
nucleus 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for SELL Gene

Pathways & Interactions for SELL Gene

genes like me logo Genes that share pathways with SELL: view

Gene Ontology (GO) - Biological Process for SELL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with SELL: view

No data available for SIGNOR curated interactions for SELL Gene

Drugs & Compounds for SELL Gene

(42) Drugs for SELL Gene - From: Novoseek and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bimosiamose Pharma inhibitor 0
GMI-1070 Pharma 0
SMART ANTI-L-SELECTIN Pharma 0

(56) Additional Compounds for SELL Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-O-Sulfogalactosylceramide (d18:1/24:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • 3-O-Sulphogalactosylceramide
151122-71-3
genes like me logo Genes that share compounds with SELL: view

Transcripts for SELL Gene

Unigene Clusters for SELL Gene

Selectin L:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SELL Gene

No ASD Table

Relevant External Links for SELL Gene

GeneLoc Exon Structure for
SELL
ECgene alternative splicing isoforms for
SELL

Expression for SELL Gene

mRNA expression in normal human tissues for SELL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SELL Gene

This gene is overexpressed in Whole Blood (x48.5).

Protein differential expression in normal tissues from HIPED for SELL Gene

This gene is overexpressed in Serum (42.7) and Plasma (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SELL Gene



SOURCE GeneReport for Unigene cluster for SELL Gene Hs.728756

mRNA Expression by UniProt/SwissProt for SELL Gene

P14151-LYAM1_HUMAN
Tissue specificity: Expressed in B-cell lines and T-lymphocytes.
genes like me logo Genes that share expression patterns with SELL: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for SELL Gene

Orthologs for SELL Gene

This gene was present in the common ancestor of animals.

Orthologs for SELL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SELL 35
  • 99.46 (n)
  • 99.73 (a)
SELL 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SELL 36
  • 77 (a)
OneToOne
SELL 35
  • 84.11 (n)
  • 78.24 (a)
dog
(Canis familiaris)
Mammalia SELL 35
  • 84.41 (n)
  • 81.99 (a)
SELL 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sell 16
Sell 36
  • 76 (a)
OneToOne
Sell 35
  • 79.66 (n)
  • 76.08 (a)
oppossum
(Monodelphis domestica)
Mammalia SELL 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SELL 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sell 35
  • 80.47 (n)
  • 77.42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sele 35
  • 59.85 (n)
  • 57.76 (a)
zebrafish
(Danio rerio)
Actinopterygii selp 36
  • 19 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta hig 36
  • 6 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lev-9 36
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 4 (a)
ManyToMany
-- 36
  • 5 (a)
ManyToMany
-- 36
  • 4 (a)
ManyToMany
-- 36
  • 4 (a)
ManyToMany
CSA.10017 36
  • 8 (a)
ManyToMany
CSA.10029 36
  • 3 (a)
ManyToMany
Species with no ortholog for SELL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SELL Gene

ENSEMBL:
Gene Tree for SELL (if available)
TreeFam:
Gene Tree for SELL (if available)

Paralogs for SELL Gene

Paralogs for SELL Gene

(2) SIMAP similar genes for SELL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SELL: view

Variants for SELL Gene

Sequence variations from dbSNP and Humsavar for SELL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1131498 - 169,707,345(-) GTCAG(C/T)TTGGT nc-transcript-variant, reference, missense
rs2229568 - 169,704,733(-) CTTTG(C/G)AGGCC nc-transcript-variant, reference, missense
rs2229569 - 169,704,697(-) CTCAC(A/C/T)CTTTG nc-transcript-variant, reference, missense
rs4987382 - 169,691,798(-) GTATG(A/G)ATGAC nc-transcript-variant, reference, missense
rs7553 -- 169,690,861(-) CCAGA(A/C)CTTTT nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SELL Gene

Variant ID Type Subtype PubMed ID
nsv872539 CNV Loss 21882294
nsv819234 CNV Gain 19587683
nsv872540 CNV Loss 21882294
nsv872541 CNV Loss 21882294

Variation tolerance for SELL Gene

Residual Variation Intolerance Score: 53.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.83; 93.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELL Gene

HapMap Linkage Disequilibrium report
SELL
Human Gene Mutation Database (HGMD)
SELL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELL Gene

Disorders for SELL Gene

MalaCards: The human disease database

(22) MalaCards diseases for SELL Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cryptococcosis
  • busse-buschke's disease
colon mucinous adenocarcinoma
  • colonic mucinous adenocarcinoma
aspiration pneumonitis
  • chemical pneumonitis
leukocyte adhesion deficiency
  • leukocyte adhesion deficiency, type iii
toxicodendron dermatitis
  • contact dermatitis due to genus toxicodendron
- elite association - COSMIC cancer census association via MalaCards
Search SELL in MalaCards View complete list of genes associated with diseases

Relevant External Links for SELL

Genetic Association Database (GAD)
SELL
Human Genome Epidemiology (HuGE) Navigator
SELL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELL
genes like me logo Genes that share disorders with SELL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SELL Gene

Publications for SELL Gene

  1. Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains. (PMID: 2664786) Siegelman M.H. … Weissman I.L. (Proc. Natl. Acad. Sci. U.S.A. 1989) 2 3 4 67
  2. Podocalyxin-like protein is an E-/L-selectin ligand on colon carcinoma cells: comparative biochemical properties of selectin ligands in host and tumor cells. (PMID: 19118161) Thomas S.N. … Konstantopoulos K. (Am. J. Physiol., Cell Physiol. 2009) 3 23
  3. In Vitro and in Vivo Characterization of Molecular Interactions between Calmodulin, Ezrin/Radixin/Moesin, and L-selectin. (PMID: 19129194) Killock D.J. … Ivetic A. (J. Biol. Chem. 2009) 3 23
  4. Alterations in neutrophil surface expression of L-selectin (CD62L) and soluble L-selectin (sL-selectin) in hemodialysis patients: relation to HCV. (PMID: 20306662) Hassoba H. … El-Gohary A. (Egypt J Immunol 2007) 3 23
  5. Levels of L-selectin (CD62L) on human leukocytes in disseminated cryptococcosis with and without associated HIV-1 infection. (PMID: 15776384) Jackson L.A. … Murphy J.W. (J. Infect. Dis. 2005) 3 23

Products for SELL Gene

Sources for SELL Gene

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