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Aliases for SELK Gene

Aliases for SELK Gene

  • Selenoprotein K 3
  • SelK 3 4
  • HSPC030 3
  • HSPC297 3

External Ids for SELK Gene

Previous GeneCards Identifiers for SELK Gene

  • GC03M053170
  • GC03M053772
  • GC03M053876
  • GC03M053894

Summaries for SELK Gene

Entrez Gene Summary for SELK Gene

  • This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is localized to the endoplasmic reticulum and is highly expressed in the heart, where it may function as an antioxidant. [provided by RefSeq, Jul 2008]

GeneCards Summary for SELK Gene

SELK (Selenoprotein K) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway and Selenium Metabolism and Selenoproteins. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for SELK Gene

  • Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration. Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins. Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation. Plays a role in protection of cells from ER stress-induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELK Gene

Genomics for SELK Gene

Regulatory Elements for SELK Gene

Genomic Location for SELK Gene

Chromosome:
3
Start:
53,884,410 bp from pter
End:
53,891,988 bp from pter
Size:
7,579 bases
Orientation:
Minus strand

Genomic View for SELK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SELK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELK Gene

Proteins for SELK Gene

  • Protein details for SELK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6D0-SELK_HUMAN
    Recommended name:
    Selenoprotein K
    Protein Accession:
    Q9Y6D0
    Secondary Accessions:
    • Q8IZQ3
    • Q9P085

    Protein attributes for SELK Gene

    Size:
    94 amino acids
    Molecular mass:
    10645 Da
    Quaternary structure:
    • Interacts with DERL1, DERL2, DERL3 and VIMP/SELS. The SELK-VIMP complex interacts with VCP. Part of a complex which includes CANX, DERL1, DERL2, DDOST/OST48, RPN1, RPN2, SELK, VIMP, STT3A AND VCP.
    SequenceCaution:
    • Sequence=AAD40194.1; Type=Erroneous termination; Positions=92; Note=Translated as Sec.; Evidence={ECO:0000305}; Sequence=AAF28975.1; Type=Erroneous termination; Positions=92; Note=Translated as Sec.; Evidence={ECO:0000305};

neXtProt entry for SELK Gene

Proteomics data for SELK Gene at MOPED

Post-translational modifications for SELK Gene

  • Cleaved by CAPN2/m-calpain in resting macrophages but not in activated macrophages. Macrophage activation up-regulates expression of the calpain inhibitor CAST/calpastatin, resulting in inhibition of CAPN2 activity (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SELK Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SELK Gene

Domains & Families for SELK Gene

Protein Domains for SELK Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SELK Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6D0

UniProtKB/Swiss-Prot:

SELK_HUMAN :
  • Belongs to the selenoprotein K family.
Family:
  • Belongs to the selenoprotein K family.
genes like me logo Genes that share domains with SELK: view

No data available for Gene Families for SELK Gene

Function for SELK Gene

Molecular function for SELK Gene

UniProtKB/Swiss-Prot Function:
Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration. Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins. Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation. Plays a role in protection of cells from ER stress-induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes.
UniProtKB/Swiss-Prot Induction:
By ER stress (at protein level). Displays a slow increase with a lag phase of 6 hours but exhibits a dramatic increase after incubation with ER stress agents for more than 12 hours with maximum induction at 24 hours. Also induced by accumulation of misfolded proteins in the ER.

Gene Ontology (GO) - Molecular Function for SELK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IPI 25117454
genes like me logo Genes that share ontologies with SELK: view
genes like me logo Genes that share phenotypes with SELK: view

Animal Models for SELK Gene

MGI Knock Outs for SELK:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SELK

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for SELK Gene

Localization for SELK Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELK Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SELK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 16962588
GO:0005789 endoplasmic reticulum membrane IDA 21220695
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SELK: view

No data available for Subcellular locations from COMPARTMENTS for SELK Gene

Pathways & Interactions for SELK Gene

genes like me logo Genes that share pathways with SELK: view

Pathways by source for SELK Gene

Interacting Proteins for SELK Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000418813%0d%0a9606.ENSP00000328182%0d%0a
Selected Interacting proteins: ENSP00000418813 Q9Y6D0-SELK_HUMAN for SELK Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for SELK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host --
GO:0006816 calcium ion transport IEA --
GO:0006979 response to oxidative stress IMP 16962588
GO:0010742 macrophage derived foam cell differentiation --
GO:0018345 protein palmitoylation --
genes like me logo Genes that share ontologies with SELK: view

No data available for SIGNOR curated interactions for SELK Gene

Drugs & Compounds for SELK Gene

(2) Drugs for SELK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenocysteine Experimental Pharma 0
Selenium Pharma 161
genes like me logo Genes that share compounds with SELK: view

Transcripts for SELK Gene

Unigene Clusters for SELK Gene

Selenoprotein K:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SELK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELK Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for SELK Gene

GeneLoc Exon Structure for
SELK

Expression for SELK Gene

mRNA expression in normal human tissues for SELK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SELK Gene

This gene is overexpressed in Bone (24.1), Breast (19.7), and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SELK Gene



SOURCE GeneReport for Unigene cluster for SELK Gene Hs.58471

mRNA Expression by UniProt/SwissProt for SELK Gene

Q9Y6D0-SELK_HUMAN
Tissue specificity: Highly expressed in heart.
genes like me logo Genes that share expression patterns with SELK: view

Protein tissue co-expression partners for SELK Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SELK Gene

Orthologs for SELK Gene

This gene was present in the common ancestor of chordates.

Orthologs for SELK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SELK 35
  • 92.91 (n)
  • 93.62 (a)
SELK 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SELK 35
  • 95.04 (n)
  • 98.94 (a)
mouse
(Mus musculus)
Mammalia Selk 35
  • 89.01 (n)
  • 91.49 (a)
Selk 16
Selk 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SELK 35
  • 98.94 (n)
  • 100 (a)
SELK 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Selk 35
  • 89.36 (n)
  • 93.62 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves SELK 35
  • 74.07 (n)
  • 71.11 (a)
SELK 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9739 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.14669 35
zebrafish
(Danio rerio)
Actinopterygii selk 35
  • 63.3 (n)
  • 69.66 (a)
selk 36
  • 68 (a)
OneToOne
Species with no ortholog for SELK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SELK Gene

ENSEMBL:
Gene Tree for SELK (if available)
TreeFam:
Gene Tree for SELK (if available)

Paralogs for SELK Gene

Pseudogenes.org Pseudogenes for SELK Gene

genes like me logo Genes that share paralogs with SELK: view

No data available for Paralogs for SELK Gene

Variants for SELK Gene

Sequence variations from dbSNP and Humsavar for SELK Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs11562 - 53,886,895(+) TAGCT(G/T)CTTCT reference, missense
rs1020082 -- 53,886,995(-) CATGG(A/G)AATAT intron-variant
rs1982171 -- 53,887,196(-) GATGA(C/T)TCTGG intron-variant
rs1982172 -- 53,886,486(-) gaggc(C/T)gaggc intron-variant
rs1992154 -- 53,892,060(-) ACTGG(A/C)AACCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SELK Gene

Variant ID Type Subtype PubMed ID
nsv876804 CNV Gain 21882294

Variation tolerance for SELK Gene

Gene Damage Index Score: 1.78; 33.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELK Gene

HapMap Linkage Disequilibrium report
SELK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELK Gene

Disorders for SELK Gene

Relevant External Links for SELK

Human Genome Epidemiology (HuGE) Navigator
SELK
genes like me logo Genes that share disorders with SELK: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SELK Gene

Publications for SELK Gene

  1. Structure-function relations, physiological roles, and evolution of mammalian ER-resident selenoproteins. (PMID: 19747065) Shchedrina V.A. … Gladyshev V.N. (Antioxid. Redox Signal. 2010) 23 67
  2. Selenoproteins and maternal nutrition. (PMID: 18790070) Pappas A.C. … Zervas G. (Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 2008) 23 67
  3. Identification and characterization of selenoprotein K: an antioxidant in cardiomyocytes. (PMID: 16962588) Lu C. … Peng X. (FEBS Lett. 2006) 23 67
  4. Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex. (PMID: 25368151) Fredericks G.J. … Hoffmann P.R. (Proc. Natl. Acad. Sci. U.S.A. 2014) 67
  5. Selenoprotein K form an intermolecular diselenide bond with unusually high redox potential. (PMID: 25117454) Liu J. … Rozovsky S. (FEBS Lett. 2014) 67

Products for SELK Gene

Sources for SELK Gene

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