SELK Gene
protein-coding GIFtS: 41
GCID: GC03M053918
|
|
SELK
| |
Aliases
for SELK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| HSPC2972 | | Selenoprotein K2 | | SelK3 |
Export aliases for SELK gene to outside databasesPrevious GC identifers: GC03M053170 GC03M053772 GC03M053876 GC03M053894 |
Summaries
for SELK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SELK:
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteineis encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have acommon stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Seccodon rather than as a stop signal. This selenoprotein is localized to the endoplasmic reticulum and is highlyexpressed in the heart, where it may function as an antioxidant. (provided by RefSeq, Jul 2008)
|
Genomic Views
for SELK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SELK gene promoter:
HOXA9B HOXA9 MEF-2A PPAR-gamma1 Meis-1a PPAR-gamma2 aMEF-2 CBF(2) Ik-1 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SELK
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SELK |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.31 Ensembl cytogenetic band: 3p21.1 SELK Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M053918: view genomic region
(about GC identifiers)
Start:
|
53,918,437 bp from pter |
End:
|
53,926,015 bp from pter |
Size:
|
7,579 bases |
Orientation:
|
minus strand |
|
Proteins
for SELK gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SELK_HUMAN, Q9Y6D0 (See
protein sequence)Recommended Name: Selenoprotein K Size: 94 amino acids; 10645 Da
Sequence caution: Sequence=AAD40194.1; Type=Erroneous termination; Positions=92; Note=Translated as Sec;Sequence=AAF28975.1; Type=Erroneous termination; Positions=92; Note=Translated as Sec;
Secondary accessions: Q8IZQ3 Q9P085Explore the universe of human proteins at neXtProt for SELK: NX_Q9Y6D0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y6D0
SELK Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_067060.2
ENSEMBL proteins: ENSP00000418813 ENSP00000417272 ENSP00000443164
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SELK for ontologies About GeneDecksing
SELK Antibody Products:
Assay Products for SELK: |
Protein
Domains /
Families
for SELK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SELK for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y6D0ProtoNet protein and cluster: Q9Y6D0 UniProtKB/Swiss-Prot: SELK_HUMAN, Q9Y6D0Similarity: Belongs to the selenoprotein K family |
Function
for SELK gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SELK (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SELK
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SELK (NM_021237) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SELK | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELK |
1 GenomeRNAi human phenotype for SELK:
Animal Models:
Mouse knock-out Selktm1.2Itl for SELK
6 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Selk):
SELK for phenotypes About GeneDecksing
|
Pathways & Interactions
for SELK gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Selenium Metabolism and Selenoproteins | | | 2 | Selenium Pathway | |
2  BioSystems Pathways for SELK
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SELK
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006979 | response to oxidative stress |
IMP | 16962588 |
SELK for ontologies About GeneDecksing
|
Drugs & Compounds
for SELK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SELK
2 HMDB Compounds for SELK About this table
Search CenterWatch for drugs/clinical trials and news about SELK
|
Transcripts
for SELK gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SELK gene: NM_021237.3 Unigene Clusters for SELK: Selenoprotein K Hs.58471 [show with all ESTs], Hs.640242 [show with all ESTs]Unigene Representative Sequences: BG259147, AK1234065 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000495461(uc021wzm.1) ENST00000488746 ENST00000487571 ENST00000485414
ENST00000541726
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SELK (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SELK
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SELK (NM_021237) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SELK | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELK |
Additional cDNA sequence: AK123406.1 12 DOTS entries: DT.448322 DT.100837679 DT.95327320 DT.120901149 DT.101957816 DT.121418654 DT.95327319 DT.121637292 DT.92432646 DT.120901147 DT.120901153 DT.120901161 24/364 AceView cDNA sequences (see all 364): BU790194 AA627989 AI357666 AA904166 N92528 AI887653 AA488761 AA594639 AA677501 CA775502 CF130741 BM271773 BM693213 AA541290 BM762385 BM692566 AA178986 BU621303 AA845585 AI004863 BM679541 BU790490 BU790164 AA488983
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SELK About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | |
|
Expression
for SELK gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SELK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATAAATTTTT
About this image
See SELK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SELK
SOURCE GeneReport for Unigene clusters: Hs.58471 Hs.640242
SABiosciences Custom PCR Arrays for SELK
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SELK
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SELK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SELK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SELK |
Orthologs
for SELK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SELK gene from 4/12 species (see all 12) About this table
ENSEMBL Gene Tree for SELK (if available)
TreeFam Gene Tree for SELK (if available) |
Paralogs
for SELK gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SELK gene
SELK for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for SELK
PGOHUM00000234156 PGOHUM00000259328 PGOHUM00000243370 PGOHUM00000243756
|
Genomic Variants
for SELK gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SELK (53918437 - 53926015 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SELK: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SELK |
|
Disorders
/ Diseases
for SELK gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SELK for disorders About GeneDecksing
OMIM gene information: 607916
OMIM disorders: --
6  diseases for SELK: About MalaCardstoxic shock syndrome staphyloenterotoxemia chronic lymphocytic leukemia lymphocytic leukemia
mastitis leukemia
2 diseases from the University of Copenhagen DISEASES database for SELK:Staphyloenterotoxemia Toxic shock syndrome Human Genome Epidemiology (HuGE) Navigator: SELK (1 document)
Export disorders for SELK gene to outside databases
|
Publications
for SELK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SELK gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with SELK) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Characterization of mammalian selenoproteomes. (PubMed id 12775843)1, 2 Kryukov G.V.... Gladyshev V.N. (2003)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- Identification and characterization of selenoprotein K: an antioxidant in cardiomyocytes. (PubMed id 16962588)1, 9 Lu C....Peng X. (2006)
- Selenoprotein K binds multiprotein complexes and is in volved in the regulation of endoplasmic reticulum homeostasis. (PubMed id 22016385)1 Shchedrina V.A....Gladyshev V.N. (2011)
- Selenoprotein K knockout mice exhibit deficient calci um flux in immune cells and impaired immune responses. (PubMed id 21220695)1 Verma S....Hoffmann P.R. (2011)
- Single nucleotide polymorphisms of matrix metalloprot einase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study E piLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
|
External Searches for SELK gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SELK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SELK gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SELK gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SELK gene:
Search GeneIP for patents involving SELK
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SELK gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SELK | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SELK | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SELK | | OriGene 3'-UTR Clone for SELK | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SELK | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SELK | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SELK | | OriGene Custom Protein Services for SELK | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SELK | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SELK | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SELK | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SELK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SELK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SELK |
| |
 |  |  |  | |
| | | | Search Tocris compounds for SELK |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | SELK Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for SELK |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELK |
|
|
|
|
