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SELK Gene

protein-coding   GIFtS: 47
GCID: GC03M053918

Selenoprotein K


  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SelK2 3
HSPC2972
Selenoprotein K2

External Ids:    Entrez Gene: 585152   Ensembl: ENSG000001138117   OMIM: 6079165   UniProtKB: Q9Y6D03   

Export aliases for SELK gene to outside databases

Previous GC identifers: GC03M053170 GC03M053772 GC03M053876 GC03M053894


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SELK Gene:
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The
selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of
selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for
the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is localized to the
endoplasmic reticulum and is highly expressed in the heart, where it may function as an antioxidant. (provided by
RefSeq, Jul 2008)

GeneCards Summary for SELK Gene:
SELK is a protein-coding gene. Diseases associated with SELK include staphyloenterotoxemia, and mastitis.

UniProtKB/Swiss-Prot: SELK_HUMAN, Q9Y6D0
Function: Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and
neutrophil migration. Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated
proteins. Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of
low-density lipoprotein and in foam cell formation. Plays a role in protection of cells from ER stress-induced
apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the SELK gene promoter:
         HOXA9B   HOXA9   MEF-2A   PPAR-gamma1   Meis-1a   PPAR-gamma2   aMEF-2   CBF(2)   Ik-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSELK promoter sequence
   Search Chromatin IP Primers for SELK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SELK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.1   

SELK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SELK gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M053918:  view genomic region     (about GC identifiers)

Start:
53,918,437 bp from pter      End:
53,926,015 bp from pter
Size:
7,579 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SELK_HUMAN, Q9Y6D0 (See protein sequence)
Recommended Name: Selenoprotein K  
Size: 94 amino acids; 10645 Da
Subunit: Interacts with DERL1, DERL2, DERL3 and VIMP/SELS. The SELK-VIMP complex interacts with VCP. Part of a
complex which includes CANX, DERL1, DERL2, DDOST/OST48, RPN1, RPN2, SELK, VIMP, STT3A AND VCP
Sequence caution: Sequence=AAD40194.1; Type=Erroneous termination; Positions=92; Note=Translated as Sec;
Sequence=AAF28975.1; Type=Erroneous termination; Positions=92; Note=Translated as Sec;
Secondary accessions: Q8IZQ3 Q9P085

Explore the universe of human proteins at neXtProt for SELK: NX_Q9Y6D0

Explore proteomics data for SELK at MOPED

Post-translational modifications: 

  • Cleaved by CAPN2/m-calpain in resting macrophages but not in activated macrophages. Macrophage activation
    up-regulates expression of the calpain inhibitor CAST/calpastatin, resulting in inhibition of CAPN2 activity (By
    similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SELK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_067060.2  
    ENSEMBL proteins: 
     ENSP00000418813   ENSP00000417272   ENSP00000443164  

    SELK Human Recombinant Protein Products:

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    Novus Biologicals SELK Proteins
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SELK

    SELK Antibody Products:

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    SELK Assay Products:

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    Cloud-Clone Corp. ELISAs for SELK
    Cloud-Clone Corp. CLIAs for SELK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR024491 Se_SelK/SelG

    Graphical View of Domain Structure for InterPro Entry Q9Y6D0

    ProtoNet protein and cluster: Q9Y6D0

    UniProtKB/Swiss-Prot: SELK_HUMAN, Q9Y6D0
    Similarity: Belongs to the selenoprotein K family


    SELK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SELK_HUMAN, Q9Y6D0
    Function: Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and
    neutrophil migration. Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated
    proteins. Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of
    low-density lipoprotein and in foam cell formation. Plays a role in protection of cells from ER stress-induced
    apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes
    Induction: By ER stress (at protein level). Displays a slow increase with a lag phase of 6 hours but exhibits a
    dramatic increase after incubation with ER stress agents for more than 12 hours with maximum induction at 24
    hours. Also induced by accumulation of misfolded proteins in the ER

    Phenotypes:
         1 GenomeRNAi human phenotype for SELK:

     Proliferating cells 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Selk):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     no phenotypic analysis 

    SELK for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Selktm1.2Itl for SELK

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SELK
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SELK

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    5 qRT-PCR Assays for microRNAs that regulate SELK:
    hsa-miR-4288 hsa-miR-452* hsa-miR-632 hsa-miR-103a-2* hsa-miR-1284
    SwitchGear 3'UTR luciferase reporter plasmidSELK 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: SELK (NM_021237)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SELK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELK

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SELK_HUMAN, Q9Y6D0: Endoplasmic reticulum membrane; Single-pass membrane protein. Cell membrane; Single-pass
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular2
    cytosol1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA16962588
    GO:0005789endoplasmic reticulum membrane IDA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    SELK for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SELK About    
    See pathways by source

    SuperPathContained pathways About
    1Selenium Pathway
    Selenium Pathway
    2Selenium Metabolism and Selenoproteins
    Selenium Metabolism and Selenoproteins
    3Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway


    3 BioSystems Pathways for SELK
        Selenium Metabolism and Selenoproteins
    Integrated Breast Cancer Pathway
    Selenium Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SELK
    Interactions:

        Search GeneGlobe Interaction Network for SELK

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006816calcium ion transport IEA--
    GO:0006979response to oxidative stress IMP16962588
    GO:0030335positive regulation of cell migration ----
    GO:0042102positive regulation of T cell proliferation IEA--
    GO:0045728respiratory burst after phagocytosis IEA--

    SELK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SELK

    2 HMDB Compounds for SELK    About this table
    CompoundSynonyms CAS #PubMed Ids
    Seleniumselenium (see all 5)7782-49-2--
    Selenocysteine(2R)-2-amino-3-selanylpropanoate (see all 8)3614-08-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SELK gene: 
    NM_021237.3  

    Unigene Clusters for SELK:

    Selenoprotein K
    Hs.58471  [show with all ESTs], Hs.640242  [show with all ESTs]
    Unigene Representative Sequences: BG259147, AK123406
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000495461(uc021wzm.1) ENST00000488746 ENST00000487571 ENST00000485414
    ENST00000541726
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate SELK:
    hsa-miR-4288 hsa-miR-452* hsa-miR-632 hsa-miR-103a-2* hsa-miR-1284
    SwitchGear 3'UTR luciferase reporter plasmidSELK 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SELK
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    GenScript: all cDNA clones in your preferred vector: SELK (NM_021237)
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    Primer
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    OriGene qPCR primer pairs and template standards for SELK
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SELK
      QuantiTect SYBR Green Assays in human, mouse, rat SELK
      QuantiFast Probe-based Assays in human, mouse, rat SELK

    Additional mRNA sequence: AK123406.1 

    12 DOTS entries:

    DT.448322  DT.100837679  DT.95327320  DT.120901149  DT.101957816  DT.121418654  DT.95327319  DT.121637292 
    DT.92432646  DT.120901147  DT.120901153  DT.120901161 

    Selected AceView cDNA sequences (see all 364):

    AA502287 AA886777 AA677799 BQ772424 AA738433 AV647210 CF129397 CD520205 
    AI748855 BI712875 BM727616 CB177529 BU687314 BU076580 BQ933723 AA449249 
    AI829103 AI952016 BM702878 AI207797 AI421525 W86189 CD638329 BM475028 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SELK    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
    SP1:                          -                                       
    SP2:                          -           -                           
    SP3:                    -     -     -                                 
    SP4:                                                                  



    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SELK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAAATTTTT
    SELK Expression
    About this image


    SELK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
    SELK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SELK Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.58471 Hs.640242

    UniProtKB/Swiss-Prot: SELK_HUMAN, Q9Y6D0
    Tissue specificity: Highly expressed in heart

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SELK gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Selk1 , 5 selenoprotein K1, 5 89.01(n)1
    91.49(a)1
      14 (18.36 cM)5
    807951  NM_019979.21  NP_064363.21 
     299683085 
    chicken
    (Gallus gallus)
    Aves SELK1 selenoprotein K 74.07(n)
    71.11(a)
      415995  NM_001025441.2  NP_001020612.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.146692 Xenopus laevis transcribed sequence with weak similarity more 70.65(n)    BJ068907.1 
    zebrafish
    (Danio rerio)
    Actinopterygii selk1 selenoprotein K 63.3(n)
    69.66(a)
      791738  NM_001004681.2  NP_001004681.2 


    ENSEMBL Gene Tree for SELK (if available)
    TreeFam Gene Tree for SELK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SELK gene

    SELK for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for SELK
    PGOHUM00000234156 PGOHUM00000259328 PGOHUM00000243370 PGOHUM00000243756


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SELK (see all 199)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1862739801,2
    --53860489(+) TTCTTC/GCCACC 1 -- us2k10--------
    rs1160549491,2
    C,F--53918732(+) TGCAGT/GGGCAT 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs117200791,2
    C,F,H--53918770(+) TGAAGC/TGATTC 1 -- ds50012Minor allele frequency- T:0.50NA CSA 6
    rs1458148291,2
    --53918803(+) GCAGGA/GATTAC 1 -- ds50010--------
    rs1489705251,2
    --53918825(+) ACCACG/TCCTGG 1 -- ds50010--------
    rs1898100631,2
    --53918848(+) ATTTTA/CGGTTT 1 -- ds50010--------
    rs98784611,2
    C,F,A,H--53918855(+) GTTTCG/CTCATG 1 -- ds50018Minor allele frequency- C:0.16NA CSA WA EA 370
    rs98782071,2
    C,F,A,H--53918861(+) TCATGT/CTGCAG 1 -- ds500113Minor allele frequency- C:0.28NA WA CSA EA 379
    rs1470859481,2
    --53918916(+) CTCCCA/TCAGTG 1 -- ds50010--------
    rs1814593851,2
    --53918946(+) CCACCA/GCGCCA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SELK (53918437 - 53926015 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SELK:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876804CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SELK
    DNA2.0 Custom Variant and Variant Library Synthesis for SELK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607916    OMIM disorders: --

    10 diseases for SELK:    
    About MalaCards
    staphyloenterotoxemia    mastitis    toxic shock syndrome    neuronal ceroid lipofuscinosis
    chronic lymphocytic leukemia    leukemia    prostate cancer    breast cancer
    prostatitis    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for SELK:
    Staphyloenterotoxemia     Toxic shock syndrome

    SELK for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: SELK (1 document)

    Export disorders for SELK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SELK gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with SELK)
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    1. Identification and characterization of selenoprotein K: an antioxidant in cardiomyocytes. (PubMed id 16962588)1, 2, 9 Lu C....Peng X. (FEBS Lett. 2006)
    2. Selenoprotein K binds multiprotein complexes and is involved in the regulation of endoplasmic reticulum homeostasis. (PubMed id 22016385)1, 2 Shchedrina V.A....Gladyshev V.N. (J. Biol. Chem. 2011)
    3. Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses. (PubMed id 21220695)1, 2 Verma S....Hoffmann P.R. (J. Immunol. 2011)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Characterization of mammalian selenoproteomes. (PubMed id 12775843)1, 2 Kryukov G.V.... Gladyshev V.N. (Science 2003)
    6. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    7. Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis. (PubMed id 23142642)1 Passantino R....Guarneri P. (Biochim. Biophys. Acta 2013)
    8. Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. (PubMed id 24144296)1 Cheng C.Y....Baird P.N. (Am. J. Hum. Genet. 2013)
    9. Polymorphisms in thioredoxin reductase and selenoprotein K genes and selenium status modulate risk of prostate cancer. (PubMed id 23133653)1 MAcplan C....Hesketh J. (PLoS ONE 2012)
    10. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (Haematologica 2011)

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    Entrez Gene: 58515 AceView: SELK Ensembl:ENSG00000113811 euGenes: HUgn58515

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    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SELK gene:
    Search GeneIP for patents involving SELK

    GeneCards and IP:
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