Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SELENOW Gene

Aliases for SELENOW Gene

  • Selenoprotein W 2 3 5
  • Selenoprotein W, 1 2 3
  • SEPW1 3 4
  • SelW 3 4

External Ids for SELENOW Gene

Previous HGNC Symbols for SELENOW Gene

  • SEPW1

Summaries for SELENOW Gene

Entrez Gene Summary for SELENOW Gene

  • This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle, heart and brain. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A retroprocessed pseudogene of this locus has been identified on chromosome 1. [provided by RefSeq, Aug 2017]

GeneCards Summary for SELENOW Gene

SELENOW (Selenoprotein W) is a Protein Coding gene. Among its related pathways are Selenium Micronutrient Network and Selenium Metabolism and Selenoproteins. An important paralog of this gene is SELENOV.

UniProtKB/Swiss-Prot for SELENOW Gene

  • Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity).

Gene Wiki entry for SELENOW Gene

Additional gene information for SELENOW Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELENOW Gene

Genomics for SELENOW Gene

Regulatory Elements for SELENOW Gene

Enhancers for SELENOW Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H047775 1.4 ENCODE dbSUPER 43.2 +0.2 154 5 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SELENOW ZC3H4 BICRA GRWD1 NOP53 INAFM1 NOP53-AS1 KDELR1 RPL18 CCDC9
GH19H047765 1.2 Ensembl ENCODE dbSUPER 38.8 -12.6 -12620 0 CTCF PKNOX1 RB1 ARID4B RAD21 ZFHX2 GLIS2 SMC3 ZNF143 EGR2 SELENOW NOP53-AS1 SNORD23
GH19H047741 1.4 ENCODE dbSUPER 29.4 -34.7 -34651 5 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 NFYC ZC3H4 BICRA ENSG00000269321 SELENOW GRWD1 NOP53 RASIP1 BSPH1 CA11 TPRX2P
GH19H047788 1.1 ENCODE dbSUPER 36.1 +10.2 10212 1 RB1 ARID4B THRB RAD21 CHAMP1 ZNF143 RUNX3 IKZF2 MIXL1 THAP11 SELENOW ZC3H4 NOP53-AS1 GC19P047784 ENSG00000271150
GH19H047756 0.7 ENCODE 39.1 -20.6 -20623 2 BCOR PKNOX1 MAX RFX5 CHAMP1 POLR2A NR2F6 EGR2 NR2F1 NR2F2 SELENOW NOP53 SNORD23 NOP53-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SELENOW on UCSC Golden Path with GeneCards custom track

Promoters for SELENOW Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110622 428 2401 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for SELENOW Gene

Chromosome:
19
Start:
47,778,572 bp from pter
End:
47,784,686 bp from pter
Size:
6,115 bases
Orientation:
Plus strand

Genomic View for SELENOW Gene

Genes around SELENOW on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELENOW Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELENOW Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELENOW Gene

Proteins for SELENOW Gene

  • Protein details for SELENOW Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63302-SELW_HUMAN
    Recommended name:
    Selenoprotein W
    Protein Accession:
    P63302
    Secondary Accessions:
    • A8MRR7
    • O15532
    • O19096
    • Q86TI9
    • Q96KM5

    Protein attributes for SELENOW Gene

    Size:
    87 amino acids
    Molecular mass:
    9448 Da
    Quaternary structure:
    • Interacts with DPYSL2, PRDX1, YWHAB, YWHAG, HSP70 and HSP90.

neXtProt entry for SELENOW Gene

Post-translational modifications for SELENOW Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SELENOW Gene

No data available for DME Specific Peptides for SELENOW Gene

Domains & Families for SELENOW Gene

Gene Families for SELENOW Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SELENOW Gene

Suggested Antigen Peptide Sequences for SELENOW Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P63302

UniProtKB/Swiss-Prot:

SELW_HUMAN :
  • Belongs to the SelWTH family. Selenoprotein W subfamily.
Family:
  • Belongs to the SelWTH family. Selenoprotein W subfamily.
genes like me logo Genes that share domains with SELENOW: view

Function for SELENOW Gene

Molecular function for SELENOW Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity).

Gene Ontology (GO) - Molecular Function for SELENOW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016209 antioxidant activity IEA --
genes like me logo Genes that share ontologies with SELENOW: view

Phenotypes for SELENOW Gene

genes like me logo Genes that share phenotypes with SELENOW: view

Animal Models for SELENOW Gene

MGI Knock Outs for SELENOW:

Animal Model Products

CRISPR Products

miRNA for SELENOW Gene

miRTarBase miRNAs that target SELENOW

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SELENOW
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SELENOW Gene

Localization for SELENOW Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELENOW Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELENOW gene
Compartment Confidence
mitochondrion 2
cytosol 2
extracellular 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SELENOW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SELENOW: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SELENOW Gene

Pathways & Interactions for SELENOW Gene

genes like me logo Genes that share pathways with SELENOW: view

Pathways by source for SELENOW Gene

Interacting Proteins for SELENOW Gene

Selected Interacting proteins: P63302-SELW_HUMAN for SELENOW Gene via IID

Gene Ontology (GO) - Biological Process for SELENOW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with SELENOW: view

No data available for SIGNOR curated interactions for SELENOW Gene

Drugs & Compounds for SELENOW Gene

(3) Drugs for SELENOW Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenium Approved, Vet_approved Pharma 185
Selenocysteine Experimental Pharma 0

(1) Additional Compounds for SELENOW Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SELENOW: view

Transcripts for SELENOW Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SELENOW
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SELENOW Gene

No ASD Table

Relevant External Links for SELENOW Gene

GeneLoc Exon Structure for
SELENOW
ECgene alternative splicing isoforms for
SELENOW

Expression for SELENOW Gene

NURSA nuclear receptor signaling pathways regulating expression of SELENOW Gene:

SELENOW

mRNA Expression by UniProt/SwissProt for SELENOW Gene:

P63302-SELW_HUMAN
Tissue specificity: Ubiquitously expressed with highest levels in skeletal muscle and heart, moderate levels in brain, spinal cord, thyroid, spleen, prostate, ovary, small intestine and colon, and lowest levels in liver and lymph node.

Evidence on tissue expression from TISSUES for SELENOW Gene

  • Nervous system(5)
  • Muscle(4.7)
  • Heart(3.5)
  • Lung(3.3)
  • Eye(2.9)
  • Pancreas(2.9)
  • Skin(2.7)
  • Intestine(2.5)
  • Spleen(2.4)
  • Thyroid gland(2.4)
  • Kidney(2.3)
  • Liver(2.2)
  • Gall bladder(2.1)
genes like me logo Genes that share expression patterns with SELENOW: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SELENOW Gene

Orthologs for SELENOW Gene

This gene was present in the common ancestor of chordates.

Orthologs for SELENOW Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEPW1 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia SEPW1 33 34
  • 91.57 (n)
cow
(Bos Taurus)
Mammalia SEPW1 33 34
  • 90.04 (n)
rat
(Rattus norvegicus)
Mammalia Sepw1 33
  • 88.76 (n)
mouse
(Mus musculus)
Mammalia Sepw1 33 34
  • 87.21 (n)
Selenow 16
platypus
(Ornithorhynchus anatinus)
Mammalia SEPW1 34
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEPW1 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEPW1 33
  • 65.48 (n)
lizard
(Anolis carolinensis)
Reptilia SEPW1 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.76 33
zebrafish
(Danio rerio)
Actinopterygii sepw1 33 34
  • 64.73 (n)
-- 33
Species where no ortholog for SELENOW was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SELENOW Gene

ENSEMBL:
Gene Tree for SELENOW (if available)
TreeFam:
Gene Tree for SELENOW (if available)

Paralogs for SELENOW Gene

Paralogs for SELENOW Gene

Pseudogenes.org Pseudogenes for SELENOW Gene

genes like me logo Genes that share paralogs with SELENOW: view

Variants for SELENOW Gene

Sequence variations from dbSNP and Humsavar for SELENOW Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000140609 -- 47,778,744(+) GTGTG(A/G)CCCGG utr-variant-5-prime
rs1000162461 -- 47,781,861(+) GATGG(A/G)TCAGA intron-variant
rs1000501732 -- 47,780,824(+) GCTGA(C/T)TGGTA intron-variant
rs1000959177 -- 47,776,941(+) AGGTC(C/T)GGCAG upstream-variant-2KB
rs1000979112 -- 47,781,088(+) CATCT(C/T)CCCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SELENOW Gene

Variant ID Type Subtype PubMed ID
esv3644559 CNV gain 21293372
nsv1058351 CNV gain 25217958
nsv1062085 CNV gain 25217958
nsv482046 CNV loss 20164927
nsv520073 CNV gain 19592680

Variation tolerance for SELENOW Gene

Residual Variation Intolerance Score: 64.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.81; 47.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELENOW Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELENOW

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELENOW Gene

Disorders for SELENOW Gene

Relevant External Links for SELENOW

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENOW

No disorders were found for SELENOW Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SELENOW Gene

Publications for SELENOW Gene

  1. Gene structure and tissue expression of human selenoprotein W, SEPW1, and identification of a retroprocessed pseudogene, SEPW1P. (PMID: 12818432) Bellingham J … Gregory-Evans CY (Biochimica et biophysica acta 2003) 3 4 22 60
  2. Conserved features of selenocysteine insertion sequence (SECIS) elements in selenoprotein W cDNAs from five species. (PMID: 9256076) Gu QP … Whanger PD (Gene 1997) 2 3 4 60
  3. Selenoprotein Gene Nomenclature. (PMID: 27645994) Gladyshev VN … Zhang Y (The Journal of biological chemistry 2016) 3 4 60
  4. Selenoprotein W modulates control of cell cycle entry. (PMID: 19387567) Hawkes WC … Dawson K (Biological trace element research 2009) 3 22 60
  5. Selenoprotein W as molecular target of methylmercury in human neuronal cells is down-regulated by GSH depletion. (PMID: 15823556) Kim YJ … Ryu JC (Biochemical and biophysical research communications 2005) 3 22 60

Products for SELENOW Gene

Sources for SELENOW Gene

Content
Loading form....