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Aliases for SELENOV Gene

Aliases for SELENOV Gene

  • Selenoprotein V 2 3 5
  • SELV 3 4

External Ids for SELENOV Gene

Summaries for SELENOV Gene

Entrez Gene Summary for SELENOV Gene

  • This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is specifically expressed in the testis. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2017]

GeneCards Summary for SELENOV Gene

SELENOV (Selenoprotein V) is a Protein Coding gene. Diseases associated with SELENOV include Staphyloenterotoxemia. Among its related pathways are Selenium Metabolism and Selenoproteins and Folate Metabolism. An important paralog of this gene is SELENOW.

UniProtKB/Swiss-Prot for SELENOV Gene

  • May be involved in a redox-related process.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELENOV Gene

Genomics for SELENOV Gene

Regulatory Elements for SELENOV Gene

Enhancers for SELENOV Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G039514 1 ENCODE 0.7 +0.4 420 1.7 ARNT ZNF48 ETS1 TCF12 ZNF121 GLIS2 GATA2 ELK1 ZNF202 SP3 ENSG00000205041 EID2B MED29 RPS16 ENSG00000269069 EID2 GC19P039520 SELENOV
GH19G039518 0.8 ENCODE 0.7 +4.5 4527 2.5 BCOR CTCF ZNF146 NFRKB CHD4 ZMYM3 ZNF121 ZNF316 GATA3 POLR2A RPS16 SELENOV GC19P039520
GH19G039506 1.4 Ensembl ENCODE 0.4 -7.8 -7770 2.1 CREB3L1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF416 ZNF548 ZNF263 EID2B TIMM50 SUPT5H RPS16 ENSG00000205041 FBL ENSG00000267892 EID2 RN7SL566P ENSG00000269688
GH19G039502 1 ENCODE 0.4 -12.2 -12158 0.2 MLX ARNT CREB3L1 ZFP64 SIN3A ZNF2 ZBTB7B SLC30A9 ZNF766 CBX5 SUPT5H ENSG00000205041 EID2B EID2 ENSG00000269069 TIMM50 PSMC4 DLL3 SELENOV
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SELENOV on UCSC Golden Path with GeneCards custom track

Genomic Location for SELENOV Gene

Chromosome:
19
Start:
39,515,113 bp from pter
End:
39,520,686 bp from pter
Size:
5,574 bases
Orientation:
Plus strand

Genomic View for SELENOV Gene

Genes around SELENOV on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELENOV Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELENOV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELENOV Gene

Proteins for SELENOV Gene

  • Protein details for SELENOV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59797-SELV_HUMAN
    Recommended name:
    Selenoprotein V
    Protein Accession:
    P59797
    Secondary Accessions:
    • Q17RG5

    Protein attributes for SELENOV Gene

    Size:
    346 amino acids
    Molecular mass:
    36800 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SELENOV Gene

Post-translational modifications for SELENOV Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SELENOV Gene

No data available for DME Specific Peptides for SELENOV Gene

Domains & Families for SELENOV Gene

Gene Families for SELENOV Gene

Protein Domains for SELENOV Gene

Suggested Antigen Peptide Sequences for SELENOV Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59797

UniProtKB/Swiss-Prot:

SELV_HUMAN :
  • Belongs to the SelWTH family.
Family:
  • Belongs to the SelWTH family.
genes like me logo Genes that share domains with SELENOV: view

Function for SELENOV Gene

Molecular function for SELENOV Gene

UniProtKB/Swiss-Prot Function:
May be involved in a redox-related process.

Gene Ontology (GO) - Molecular Function for SELENOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SELENOV: view
genes like me logo Genes that share phenotypes with SELENOV: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SELENOV

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SELENOV Gene

Localization for SELENOV Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SELENOV Gene

Pathways & Interactions for SELENOV Gene

genes like me logo Genes that share pathways with SELENOV: view

Pathways by source for SELENOV Gene

Gene Ontology (GO) - Biological Process for SELENOV Gene

None

No data available for SIGNOR curated interactions for SELENOV Gene

Drugs & Compounds for SELENOV Gene

No Compound Related Data Available

Transcripts for SELENOV Gene

mRNA/cDNA for SELENOV Gene

(2) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SELENOV

Alternative Splicing Database (ASD) splice patterns (SP) for SELENOV Gene

No ASD Table

Relevant External Links for SELENOV Gene

GeneLoc Exon Structure for
SELENOV
ECgene alternative splicing isoforms for
SELENOV

Expression for SELENOV Gene

mRNA Expression by UniProt/SwissProt for SELENOV Gene:

P59797-SELV_HUMAN
Tissue specificity: Testis specific.

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SELENOV Gene

Orthologs for SELENOV Gene

This gene was present in the common ancestor of chordates.

Orthologs for SELENOV Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SELV 34 35
  • 99.04 (n)
dog
(Canis familiaris)
Mammalia LOC102151122 34
  • 72 (n)
-- 35
  • 16 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Selv 34
  • 60.34 (n)
mouse
(Mus musculus)
Mammalia BC089491 34 35
  • 59.3 (n)
Selenov 16
cow
(Bos Taurus)
Mammalia SELV 35
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii sepw1 35
  • 47 (a)
OneToMany
Species where no ortholog for SELENOV was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SELENOV Gene

ENSEMBL:
Gene Tree for SELENOV (if available)
TreeFam:
Gene Tree for SELENOV (if available)

Paralogs for SELENOV Gene

Paralogs for SELENOV Gene

genes like me logo Genes that share paralogs with SELENOV: view

Variants for SELENOV Gene

Sequence variations from dbSNP and Humsavar for SELENOV Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000046545 -- 39,519,590(+) GAGCC(C/T)AGGAG intron-variant
rs1000967317 -- 39,516,575(+) CAGGC(C/T)GGAGT intron-variant
rs1000997495 -- 39,515,627(+) CGCTC(C/G)CCGTC reference, missense
rs1001375560 -- 39,520,531(+) GGGAA(A/G)CGGGG utr-variant-3-prime
rs1001445444 -- 39,515,111(+) GTGGT(-/CG)CGCCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SELENOV Gene

Variant ID Type Subtype PubMed ID
esv3644330 CNV loss 21293372
nsv522811 CNV loss 19592680
nsv579509 CNV gain 21841781
nsv953573 CNV deletion 24416366

Variation tolerance for SELENOV Gene

Gene Damage Index Score: 3.58; 56.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELENOV Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELENOV

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELENOV Gene

Disorders for SELENOV Gene

MalaCards: The human disease database

(1) MalaCards diseases for SELENOV Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
staphyloenterotoxemia
  • staphylococcal food poisoning
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SELENOV

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENOV
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENOV
genes like me logo Genes that share disorders with SELENOV: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SELENOV Gene

Publications for SELENOV Gene

  1. Characterization of mammalian selenoproteomes. (PMID: 12775843) Kryukov G.V. … Gladyshev V.N. (Science 2003) 2 3 4 64
  2. Selenoprotein Gene Nomenclature. (PMID: 27645994) Gladyshev V.N. … Zhang Y. (J. Biol. Chem. 2016) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3 64

Products for SELENOV Gene

Sources for SELENOV Gene

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