Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SELENOV Gene

Aliases for SELENOV Gene

  • Selenoprotein V 2 3 5
  • SELV 3

External Ids for SELENOV Gene

Summaries for SELENOV Gene

Entrez Gene Summary for SELENOV Gene

  • This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]

GeneCards Summary for SELENOV Gene

SELENOV (Selenoprotein V) is a Protein Coding gene. Diseases associated with SELENOV include Staphyloenterotoxemia. Among its related pathways are Folate Metabolism and Selenium Metabolism and Selenoproteins. An important paralog of this gene is SELENOW.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELENOV Gene

Genomics for SELENOV Gene

Regulatory Elements for SELENOV Gene

Enhancers for SELENOV Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F039518 0.4 ENCODE 0.8 +4.5 4527 2.5 BCOR CTCF ZNF146 ZMYM3 CHD4 ZNF121 ZNF316 GATA3 POLR2A GATA2 RPS16 GC19P039520 SELENOV
GH19F039516 0.4 Ensembl 0.8 +1.6 1588 0.2 ZNF121 MCM7 ZNF366 ZNF133 ZNF24 ZNF48 EGR2 GC19P039520 SELENOV
GH19F039514 0.2 ENCODE 0.8 +0.4 420 1.7 ARNT ZNF48 ZNF121 GLIS2 GATA2 ZNF202 SP3 MEF2D SMARCA4 MYNN RPS16 FBL SUPT5H GC19P039520 SELENOV
GH19F039506 1.2 Ensembl ENCODE 0.4 -7.8 -7770 2.1 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 RPS16 FBL TIMM50 EID2B ENSG00000269688 ENSG00000269069 RN7SL566P ENSG00000268366 SERTAD3 ENSG00000205041
GH19F039502 0.2 ENCODE 0.4 -12.2 -12158 0.2 ATF1 CREB3L1 MLX ZFP64 SIN3A ZNF48 ZNF2 SLC30A9 GLIS2 CBX5 ENSG00000205041 ENSG00000269069 SUPT5H EID2B EID2 TIMM50 PSMC4 DLL3 SELENOV
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SELENOV on UCSC Golden Path with GeneCards custom track

Promoters for SELENOV Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001817517 187 201 ZNF121 GLIS2 ZNF202 SP3 ZEB2 ZNF843 MEF2D ZFP69B IKZF1 ZNF524
ENSR00001817518 587 201 HDAC1 TBL1XR1 ARNT ZNF121 GLIS2 GATA2 ZNF202 SP3 ZEB2 NR2F2
ENSR00001817519 987 201 HDAC1 ESRRA ARNT ZNF175 ZNF48 FOSL1 GATA2 ZNF366 ZNF584 EZH2

Genomic Location for SELENOV Gene

Chromosome:
19
Start:
39,515,113 bp from pter
End:
39,520,686 bp from pter
Size:
5,574 bases
Orientation:
Plus strand

Genomic View for SELENOV Gene

Genes around SELENOV on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELENOV Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELENOV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELENOV Gene

Proteins for SELENOV Gene

  • Protein details for SELENOV Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A087WYK0
    Recommended name:
    Selenoprotein V
    Protein Accession:
    A0A087WYK0

    Protein attributes for SELENOV Gene

    Size:
    346 amino acids
    Molecular mass:
    36904 Da
    Quaternary structure:
    No Data Available
  • Protein details for SELENOV Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    C9IZ47
    Recommended name:
    Selenoprotein V
    Protein Accession:
    C9IZ47

    Protein attributes for SELENOV Gene

    Size:
    345 amino acids
    Molecular mass:
    36650 Da
    Quaternary structure:
    No Data Available
  • Protein details for SELENOV Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    M0QZN9
    Recommended name:
    Selenoprotein V
    Protein Accession:
    M0QZN9

    Protein attributes for SELENOV Gene

    Size:
    73 amino acids
    Molecular mass:
    7811 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SELENOV Gene

Post-translational modifications for SELENOV Gene

No Post-translational modifications

Other Protein References for SELENOV Gene

No data available for DME Specific Peptides for SELENOV Gene

Domains & Families for SELENOV Gene

Gene Families for SELENOV Gene

Protein Domains for SELENOV Gene

Suggested Antigen Peptide Sequences for SELENOV Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SELENOV: view

No data available for UniProtKB/Swiss-Prot for SELENOV Gene

Function for SELENOV Gene

Gene Ontology (GO) - Molecular Function for SELENOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SELENOV: view
genes like me logo Genes that share phenotypes with SELENOV: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SELENOV Gene

Localization for SELENOV Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SELENOV Gene

Pathways & Interactions for SELENOV Gene

genes like me logo Genes that share pathways with SELENOV: view

Pathways by source for SELENOV Gene

2 BioSystems pathways for SELENOV Gene

Interacting Proteins for SELENOV Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000333956%0d%0a9606.ENSP00000298585%0d%0a9606.ENSP00000311778%0d%0a9606.ENSP00000367164%0d%0a9606.ENSP00000083182%0d%0a
Selected Interacting proteins: ENSP00000333956 for SELENOV Gene via STRING

Gene Ontology (GO) - Biological Process for SELENOV Gene

None

No data available for SIGNOR curated interactions for SELENOV Gene

Transcripts for SELENOV Gene

mRNA/cDNA for SELENOV Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SELENOV Gene

Selenoprotein V:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELENOV Gene

No ASD Table

Relevant External Links for SELENOV Gene

GeneLoc Exon Structure for
SELENOV
ECgene alternative splicing isoforms for
SELENOV

Expression for SELENOV Gene

SOURCE GeneReport for Unigene cluster for SELENOV Gene:

Hs.319284
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SELENOV Gene

Orthologs for SELENOV Gene

This gene was present in the common ancestor of chordates.

Orthologs for SELENOV Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SELV 34 35
  • 99.04 (n)
dog
(Canis familiaris)
Mammalia LOC102151122 34
  • 72 (n)
-- 35
  • 16 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Selv 34
  • 60.34 (n)
mouse
(Mus musculus)
Mammalia BC089491 34 16 35
  • 59.3 (n)
cow
(Bos Taurus)
Mammalia SELV 35
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii sepw1 35
  • 47 (a)
OneToMany
Species where no ortholog for SELENOV was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SELENOV Gene

ENSEMBL:
Gene Tree for SELENOV (if available)
TreeFam:
Gene Tree for SELENOV (if available)

Paralogs for SELENOV Gene

Paralogs for SELENOV Gene

genes like me logo Genes that share paralogs with SELENOV: view

Variants for SELENOV Gene

Sequence variations from dbSNP and Humsavar for SELENOV Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10410648 -- 39,514,876(+) CTGAT(C/G)CCTGC upstream-variant-2KB
rs111299652 -- 39,518,526(+) ATAGG(A/G)TGCCC intron-variant
rs111657235 -- 39,520,761(+) GCCAT(A/G)ATTAT downstream-variant-500B
rs112098798 -- 39,513,969(+) AAAAA(A/T)GTTTT upstream-variant-2KB
rs112129597 -- 39,514,418(+) TCCCA(C/G)TAGTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SELENOV Gene

Variant ID Type Subtype PubMed ID
esv3644330 CNV loss 21293372
nsv522811 CNV loss 19592680
nsv579509 CNV gain 21841781
nsv953573 CNV deletion 24416366

Variation tolerance for SELENOV Gene

Gene Damage Index Score: 3.58; 56.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELENOV Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELENOV

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELENOV Gene

Disorders for SELENOV Gene

MalaCards: The human disease database

(1) MalaCards diseases for SELENOV Gene - From: DISEASES

Disorder Aliases PubMed IDs
staphyloenterotoxemia
  • staphylococcal food poisoning
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SELENOV

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENOV
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENOV
genes like me logo Genes that share disorders with SELENOV: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SELENOV Gene

Publications for SELENOV Gene

  1. Characterization of mammalian selenoproteomes. (PMID: 12775843) Kryukov G.V. … Gladyshev V.N. (Science 2003) 2 3 64
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  3. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3 64
  4. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PMID: 21048031) Casabonne D. … de Sanjose S. (Haematologica 2011) 3 64
  5. Selenoproteins and maternal nutrition. (PMID: 18790070) Pappas A.C. … Zervas G. (Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 2008) 22 64

Products for SELENOV Gene

Sources for SELENOV Gene

Content
Loading form....