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Aliases for SELENOT Gene

Aliases for SELENOT Gene

  • Selenoprotein T 2 3 5
  • Thioredoxin Reductase-Like Enzyme 3 4
  • SELT 3 4
  • EC 1.8.1.9 4

External Ids for SELENOT Gene

Summaries for SELENOT Gene

Entrez Gene Summary for SELENOT Gene

  • This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in mice indicate a crucial role for this gene in the protection of dopaminergic neurons against oxidative stress in Parkinson's disease, and in the control of glucose homeostasis in pancreatic beta-cells. A pseudogene of this locus has been identified on chromosome 9. [provided by RefSeq, Aug 2017]

GeneCards Summary for SELENOT Gene

SELENOT (Selenoprotein T) is a Protein Coding gene. Among its related pathways are Selenium Micronutrient Network and Selenium Metabolism and Selenoproteins.

UniProtKB/Swiss-Prot for SELENOT Gene

  • Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress ans cell death (PubMed:26866473). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (By similarity).

Gene Wiki entry for SELENOT Gene

Additional gene information for SELENOT Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELENOT Gene

Genomics for SELENOT Gene

Regulatory Elements for SELENOT Gene

Enhancers for SELENOT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H150598 1.7 Ensembl ENCODE dbSUPER 6 -0.3 -290 8 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 EIF2A RPL32P9 LOC730021 COMMD2 TSC22D2 ERICH6-AS1 ERICH6 SELENOT
GH03H150634 0.8 Ensembl ENCODE 11.7 +33.1 33108 2 ZSCAN29 ELF1 EBF1 RUNX3 SPI1 SELENOT SERP1 ERICH6 ERICH6-AS1 EIF2A GC03P150627
GH03H150543 1.4 ENCODE dbSUPER 5.1 -56.6 -56605 4 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 EIF2A SERP1 SELENOT GC03M150475
GH03H150662 0.6 Ensembl 11.3 +59.8 59826 0 ZNF316 L3MBTL2 NRF1 MAFG NFE2 EMSY ERICH6 ERICH6-AS1 SERP1 SELENOT ENSG00000243273 MINDY4B GC03P150627
GH03H150723 0.5 dbSUPER 10.7 +121.1 121104 1 RFX1 ZNF366 ZNF512 IKZF1 NFE2 ERICH6-AS1 SIAH2-AS1 SIAH2 ENSG00000243273 MINDY4B SELENOT SERP1 SNRPCP3 LOC101928105
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SELENOT on UCSC Golden Path with GeneCards custom track

Promoters for SELENOT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000160152 626 2600 HDGF ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 FOS

Genomic Location for SELENOT Gene

Chromosome:
3
Start:
150,602,875 bp from pter
End:
150,630,447 bp from pter
Size:
27,573 bases
Orientation:
Plus strand

Genomic View for SELENOT Gene

Genes around SELENOT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELENOT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELENOT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELENOT Gene

Proteins for SELENOT Gene

  • Protein details for SELENOT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62341-SELT_HUMAN
    Recommended name:
    Selenoprotein T
    Protein Accession:
    P62341
    Secondary Accessions:
    • O95904
    • Q8IY80
    • Q9CZ45
    • Q9NZJ3

    Protein attributes for SELENOT Gene

    Size:
    195 amino acids
    Molecular mass:
    22324 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD20063.1; Type=Erroneous termination; Positions=49; Note=Translated as Sec.; Evidence={ECO:0000305}; Sequence=AAF13696.1; Type=Frameshift; Positions=27; Evidence={ECO:0000305}; Sequence=AAQ88462.1; Type=Erroneous termination; Positions=49; Note=Translated as Sec.; Evidence={ECO:0000305}; Sequence=AAQ88463.1; Type=Erroneous termination; Positions=49; Note=Translated as Sec.; Evidence={ECO:0000305};

neXtProt entry for SELENOT Gene

Post-translational modifications for SELENOT Gene

  • May contain a selenide-sulfide bond between Cys-46 and Sec-49. This bond is speculated to serve as redox-active pair (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SELENOT Gene

No data available for DME Specific Peptides for SELENOT Gene

Domains & Families for SELENOT Gene

Gene Families for SELENOT Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SELENOT Gene

Suggested Antigen Peptide Sequences for SELENOT Gene

Graphical View of Domain Structure for InterPro Entry

P62341

UniProtKB/Swiss-Prot:

SELT_HUMAN :
  • Belongs to the SelWTH family. Selenoprotein T subfamily.
Family:
  • Belongs to the SelWTH family. Selenoprotein T subfamily.
genes like me logo Genes that share domains with SELENOT: view

Function for SELENOT Gene

Molecular function for SELENOT Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH.
UniProtKB/Swiss-Prot Function:
Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress ans cell death (PubMed:26866473). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (By similarity).
UniProtKB/Swiss-Prot Induction:
Induced by Parkinson disease-inducing neurotoxins such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

Enzyme Numbers (IUBMB) for SELENOT Gene

Gene Ontology (GO) - Molecular Function for SELENOT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004791 thioredoxin-disulfide reductase activity ISS --
GO:0008430 selenium binding NAS 10567350
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with SELENOT: view
genes like me logo Genes that share phenotypes with SELENOT: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SELENOT
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SELENOT Gene

Localization for SELENOT Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELENOT Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELENOT gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SELENOT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SELENOT: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SELENOT Gene

Pathways & Interactions for SELENOT Gene

genes like me logo Genes that share pathways with SELENOT: view

Pathways by source for SELENOT Gene

Interacting Proteins for SELENOT Gene

Gene Ontology (GO) - Biological Process for SELENOT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001514 selenocysteine incorporation NAS 10567350
GO:0007204 positive regulation of cytosolic calcium ion concentration ISS --
GO:0009749 response to glucose ISS,IEA --
GO:0031016 pancreas development ISS,IEA --
GO:0035773 insulin secretion involved in cellular response to glucose stimulus IEA,ISS --
genes like me logo Genes that share ontologies with SELENOT: view

No data available for SIGNOR curated interactions for SELENOT Gene

Drugs & Compounds for SELENOT Gene

(1) Drugs for SELENOT Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with SELENOT: view

Transcripts for SELENOT Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SELENOT
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SELENOT Gene

No ASD Table

Relevant External Links for SELENOT Gene

GeneLoc Exon Structure for
SELENOT
ECgene alternative splicing isoforms for
SELENOT

Expression for SELENOT Gene

mRNA Expression by UniProt/SwissProt for SELENOT Gene:

P62341-SELT_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in the endocrine pancreas.

Evidence on tissue expression from TISSUES for SELENOT Gene

  • Nervous system(5)
  • Skin(4.8)
  • Pancreas(4.4)
  • Bone marrow(4.3)
  • Liver(4.2)
  • Kidney(2.5)
  • Lung(2.2)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SELENOT Gene

Orthologs for SELENOT Gene

This gene was present in the common ancestor of animals.

Orthologs for SELENOT Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SELT 33 34
  • 96.07 (n)
cow
(Bos Taurus)
Mammalia SELT 33 34
  • 95.9 (n)
mouse
(Mus musculus)
Mammalia Selt 33 34
  • 95.21 (n)
Selenot 16
rat
(Rattus norvegicus)
Mammalia Selt 33
  • 95.21 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves SELT 33 34
  • 86.96 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia selt 33
  • 82.97 (n)
MGC75917 33
zebrafish
(Danio rerio)
Actinopterygii selt1a 33 34
  • 75.51 (n)
selt1b 34
  • 75 (a)
OneToMany
selt2 34
  • 46 (a)
OneToMany
sept1a 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8427 33
fruit fly
(Drosophila melanogaster)
Insecta CG3887 33 34
  • 53.67 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009202 33
  • 52.16 (n)
worm
(Caenorhabditis elegans)
Secernentea C35C5.3 34
  • 24 (a)
OneToMany
F28H7.4 34
  • 23 (a)
OneToMany
Species where no ortholog for SELENOT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SELENOT Gene

ENSEMBL:
Gene Tree for SELENOT (if available)
TreeFam:
Gene Tree for SELENOT (if available)

Paralogs for SELENOT Gene

Pseudogenes.org Pseudogenes for SELENOT Gene

genes like me logo Genes that share paralogs with SELENOT: view

No data available for Paralogs for SELENOT Gene

Variants for SELENOT Gene

Sequence variations from dbSNP and Humsavar for SELENOT Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000002145 -- 150,614,875(+) TTATT(A/T)TTATT intron-variant
rs1000030094 -- 150,601,650(+) TGGAC(A/C)CTCTC intron-variant, upstream-variant-2KB
rs1000158171 -- 150,624,324(+) TCTGT(C/G)CAACA intron-variant
rs1000266382 -- 150,607,741(+) ATGTT(C/T)AGTGT intron-variant
rs1000353002 -- 150,615,011(+) CCCTC(C/T)CCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SELENOT Gene

Variant ID Type Subtype PubMed ID
esv3569056 CNV loss 25503493
nsv963367 CNV duplication 23825009

Variation tolerance for SELENOT Gene

Residual Variation Intolerance Score: 43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELENOT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELENOT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELENOT Gene

Disorders for SELENOT Gene

UniProtKB/Swiss-Prot

SELT_HUMAN
  • Note=mRNA levels are increased more than 200-folds in the caudate putamen from Parkinson disease (PD) patients compared to control subjects. In conditional brain knockout mice, treatment with PD-inducing neurotoxins provoke rapid and severe parkinsonian-like motor defects. {ECO:0000269 PubMed:26866473}.

Relevant External Links for SELENOT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENOT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENOT

No disorders were found for SELENOT Gene.

No data available for MalaCards and Genatlas for SELENOT Gene

Publications for SELENOT Gene

  1. New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements. (PMID: 10567350) Kryukov GV … Gladyshev VN (The Journal of biological chemistry 1999) 2 3 4 60
  2. Selenoprotein Gene Nomenclature. (PMID: 27645994) Gladyshev VN … Zhang Y (The Journal of biological chemistry 2016) 3 4 60
  3. Selenoprotein T Exerts an Essential Oxidoreductase Activity That Protects Dopaminergic Neurons in Mouse Models of Parkinson's Disease. (PMID: 26866473) Boukhzar L … Anouar Y (Antioxidants & redox signaling 2016) 3 4 60
  4. The PACAP-regulated gene selenoprotein T is abundantly expressed in mouse and human β-cells and its targeted inactivation impairs glucose tolerance. (PMID: 23913443) Prevost G … Anouar Y (Endocrinology 2013) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for SELENOT Gene

Sources for SELENOT Gene

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