Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SELENOT Gene

Aliases for SELENOT Gene

  • Selenoprotein T 2 3 5
  • SELT 3

External Ids for SELENOT Gene

Summaries for SELENOT Gene

Entrez Gene Summary for SELENOT Gene

  • This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]

GeneCards Summary for SELENOT Gene

SELENOT (Selenoprotein T) is a Protein Coding gene. Among its related pathways are Folate Metabolism and Selenium Metabolism and Selenoproteins.

Gene Wiki entry for SELENOT Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELENOT Gene

Genomics for SELENOT Gene

Regulatory Elements for SELENOT Gene

Enhancers for SELENOT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F150634 0.8 Ensembl ENCODE 11.6 +33.1 33108 2.1 MTA2 TCF7 ZSCAN29 EBF1 SPI1 SELENOT SERP1 ERICH6 ERICH6-AS1 EIF2A GC03P150627
GH03F150598 1.2 ENCODE 6 -0.3 -290 8.8 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A YBX1 FEZF1 EIF2A RPL32P9 LOC730021 ERICH6 ERICH6-AS1 SELENOT
GH03F150662 0.6 Ensembl 11.3 +59.8 59826 0.2 ZNF316 L3MBTL2 NRF1 MAFG NFE2 EMSY ERICH6 ERICH6-AS1 SELENOT SERP1 FAM188B2 ENSG00000243273 GC03P150627
GH03F150631 0.5 FANTOM5 12 +28.3 28335 0.0 FOSL1 SIN3A FOSL2 SELENOT SERP1 ERICH6-AS1 ERICH6 CLRN1 GC03P150627
GH03F150543 1.1 ENCODE 5.1 -56.6 -56605 4.7 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 EIF2A WWTR1-AS1 WWTR1-IT1 SERP1 SELENOT GC03M150475
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SELENOT on UCSC Golden Path with GeneCards custom track

Promoters for SELENOT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001376663 725 3601 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for SELENOT Gene

Chromosome:
3
Start:
150,602,875 bp from pter
End:
150,630,447 bp from pter
Size:
27,573 bases
Orientation:
Plus strand

Genomic View for SELENOT Gene

Genes around SELENOT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELENOT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELENOT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELENOT Gene

Proteins for SELENOT Gene

  • Protein details for SELENOT Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A087WVA1
    Recommended name:
    Selenoprotein T
    Protein Accession:
    A0A087WVA1

    Protein attributes for SELENOT Gene

    Size:
    195 amino acids
    Molecular mass:
    22344 Da
    Quaternary structure:
    No Data Available
  • Protein details for SELENOT Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    F8WBD0
    Recommended name:
    Selenoprotein T
    Protein Accession:
    F8WBD0

    Protein attributes for SELENOT Gene

    Size:
    45 amino acids
    Molecular mass:
    4858 Da
    Quaternary structure:
    No Data Available
  • Protein details for SELENOT Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Q6IAK0
    Recommended name:
    Selenoprotein T
    Protein Accession:
    Q6IAK0

    Protein attributes for SELENOT Gene

    Size:
    137 amino acids
    Molecular mass:
    15845 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SELENOT Gene

Post-translational modifications for SELENOT Gene

No Post-translational modifications

Other Protein References for SELENOT Gene

No data available for DME Specific Peptides for SELENOT Gene

Domains & Families for SELENOT Gene

Gene Families for SELENOT Gene

Protein Domains for SELENOT Gene

Suggested Antigen Peptide Sequences for SELENOT Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SELENOT: view

No data available for UniProtKB/Swiss-Prot for SELENOT Gene

Function for SELENOT Gene

Gene Ontology (GO) - Molecular Function for SELENOT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008430 selenium binding NAS 10567350
genes like me logo Genes that share ontologies with SELENOT: view
genes like me logo Genes that share phenotypes with SELENOT: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SELENOT Gene

Localization for SELENOT Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELENOT gene
Compartment Confidence
endoplasmic reticulum 3
plasma membrane 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SELENOT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SELENOT: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SELENOT Gene

Pathways & Interactions for SELENOT Gene

genes like me logo Genes that share pathways with SELENOT: view

Pathways by source for SELENOT Gene

2 BioSystems pathways for SELENOT Gene

Interacting Proteins for SELENOT Gene

Gene Ontology (GO) - Biological Process for SELENOT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001514 selenocysteine incorporation NAS 10567350
genes like me logo Genes that share ontologies with SELENOT: view

No data available for SIGNOR curated interactions for SELENOT Gene

Drugs & Compounds for SELENOT Gene

(1) Drugs for SELENOT Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with SELENOT: view

Transcripts for SELENOT Gene

Unigene Clusters for SELENOT Gene

Selenoprotein T:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELENOT Gene

No ASD Table

Relevant External Links for SELENOT Gene

GeneLoc Exon Structure for
SELENOT
ECgene alternative splicing isoforms for
SELENOT

Expression for SELENOT Gene

SOURCE GeneReport for Unigene cluster for SELENOT Gene:

Hs.369052
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SELENOT Gene

Orthologs for SELENOT Gene

This gene was present in the common ancestor of animals.

Orthologs for SELENOT Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SELT 34 35
  • 96.07 (n)
cow
(Bos Taurus)
Mammalia SELT 34 35
  • 95.9 (n)
mouse
(Mus musculus)
Mammalia Selt 34 16 35
  • 95.21 (n)
rat
(Rattus norvegicus)
Mammalia Selt 34
  • 95.21 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves SELT 34 35
  • 86.96 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia selt 34
  • 82.97 (n)
MGC75917 34
zebrafish
(Danio rerio)
Actinopterygii selt1a 34 35
  • 75.51 (n)
selt1b 35
  • 75 (a)
OneToMany
selt2 35
  • 46 (a)
OneToMany
sept1a 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8427 34
fruit fly
(Drosophila melanogaster)
Insecta CG3887 34 35
  • 53.67 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009202 34
  • 52.16 (n)
worm
(Caenorhabditis elegans)
Secernentea C35C5.3 35
  • 24 (a)
OneToMany
F28H7.4 35
  • 23 (a)
OneToMany
Species where no ortholog for SELENOT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SELENOT Gene

ENSEMBL:
Gene Tree for SELENOT (if available)
TreeFam:
Gene Tree for SELENOT (if available)

Paralogs for SELENOT Gene

Pseudogenes.org Pseudogenes for SELENOT Gene

genes like me logo Genes that share paralogs with SELENOT: view

No data available for Paralogs for SELENOT Gene

Variants for SELENOT Gene

Sequence variations from dbSNP and Humsavar for SELENOT Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10557795 -- 150,606,560(+) AACAC(-/TT)AACAT intron-variant
rs1058455 -- 150,629,648(+) ATCTT(G/T)TGGAG utr-variant-3-prime
rs10663147 -- 150,605,037(+) GTCTC(-/A/AA/AAA/AAAA)AAAAA intron-variant, upstream-variant-2KB
rs10663245 -- 150,623,592(+) AACTC(-/CT)CTCTC intron-variant
rs10935812 -- 150,603,060(+) ATGCA(A/G)AACTC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SELENOT Gene

Variant ID Type Subtype PubMed ID
esv3569056 CNV loss 25503493
nsv963367 CNV duplication 23825009

Variation tolerance for SELENOT Gene

Residual Variation Intolerance Score: 43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELENOT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELENOT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELENOT Gene

Disorders for SELENOT Gene

Relevant External Links for SELENOT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENOT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENOT

No disorders were found for SELENOT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SELENOT Gene

Publications for SELENOT Gene

  1. New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements. (PMID: 10567350) Kryukov G.V. … Gladyshev V.N. (J. Biol. Chem. 1999) 2 3 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. The PACAP-regulated gene selenoprotein T is abundantly expressed in mouse and human I^-cells and its targeted inactivation impairs glucose tolerance. (PMID: 23913443) Prevost G. … Anouar Y. (Endocrinology 2013) 3 64
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64
  5. Selenoproteins and maternal nutrition. (PMID: 18790070) Pappas A.C. … Zervas G. (Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 2008) 22 64

Products for SELENOT Gene

Sources for SELENOT Gene

Content
Loading form....