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Aliases for SELENOS Gene

Aliases for SELENOS Gene

  • Selenoprotein S 2 3 5
  • VCP-Interacting Membrane Protein 2 3 4
  • Valosin-Containing Protein-Interacting Membrane Protein 2 3
  • VCP Interacting Membrane Selenoprotein 2 3
  • VIMP 3 4
  • SELS 3 4
  • AD-015 3
  • ADO15 3
  • SBBI8 3
  • SEPS1 3

External Ids for SELENOS Gene

Previous HGNC Symbols for SELENOS Gene

  • VIMP

Summaries for SELENOS Gene

Entrez Gene Summary for SELENOS Gene

  • This gene encodes a member of the selenoprotein family, characterized by a selenocysteine (Sec) residue at the active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]

GeneCards Summary for SELENOS Gene

SELENOS (Selenoprotein S) is a Protein Coding gene. Diseases associated with SELENOS include Pontocerebellar Hypoplasia Type 2D. Among its related pathways are Protein processing in endoplasmic reticulum and Folate Metabolism.

UniProtKB/Swiss-Prot for SELENOS Gene

  • Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.

Gene Wiki entry for SELENOS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELENOS Gene

Genomics for SELENOS Gene

Regulatory Elements for SELENOS Gene

Enhancers for SELENOS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F101156 0.6 Ensembl ENCODE 11.5 +120.8 120805 0.6 HDGF PKNOX1 MAX EBF1 RELA ZNF143 NFE2 ETV6 CREM MTA2 CHSY1 SELENOS GC15P101159 LOC105371026
GH15F101640 0.8 Ensembl ENCODE 11.2 -364.5 -364474 2.7 ELF3 PKNOX1 WRNIP1 KLF17 ARID4B ZNF2 RAD21 ZBTB40 RFX5 ZNF143 TM2D3 TARSL2 LOC100128108 SNRPA1 SELENOS RNU6-807P LOC101927505
GH15F101723 0.9 ENCODE 10.5 -446.6 -446605 2.1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 LOC100128108 SELENOS TM2D3 TARSL2
GH15F101275 0.9 FANTOM5 ENCODE 0.8 -0.1 -51 3.2 ATF1 CREB3L1 ARID4B SIN3A GLI4 DMAP1 ZNF48 ETS1 ZNF121 GLIS2 CHSY1 RNU6-807P SELENOS SNRPA1
GH15F101279 0.2 ENCODE 0.8 -2.9 -2934 2.0 JUND POLR2A SCRT2 ZBTB33 ATF2 CHSY1 RNU6-807P SELENOS SNRPA1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SELENOS on UCSC Golden Path with GeneCards custom track

Promoters for SELENOS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000023420 420 1801 ATF1 CREB3L1 ARID4B SIN3A GLI4 DMAP1 ZNF48 ETS1 GLIS2 ELK1

Genomic Location for SELENOS Gene

Chromosome:
15
Start:
101,270,817 bp from pter
End:
101,277,520 bp from pter
Size:
6,704 bases
Orientation:
Minus strand

Genomic View for SELENOS Gene

Genes around SELENOS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELENOS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELENOS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELENOS Gene

Proteins for SELENOS Gene

  • Protein details for SELENOS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQE4-SELS_HUMAN
    Recommended name:
    Selenoprotein S
    Protein Accession:
    Q9BQE4
    Secondary Accessions:
    • Q3B771
    • Q9P0I6

    Protein attributes for SELENOS Gene

    Size:
    189 amino acids
    Molecular mass:
    21163 Da
    Quaternary structure:
    • Interacts with DERL1 and (via VIM motif) with VCP, suggesting that it forms a membrane complex with DERL1 that serves as a receptor for VCP. Also interacts with DERL2, DERL3 and SELK. The SELK-VIMP complex interacts with VCP. Part of a complex which includes CANX, DERL1, DERL2, DDOST/OST48, RPN1, RPN2, SELK, STT3A, VCP AND VIMP.
    SequenceCaution:
    • Sequence=AAF67483.1; Type=Frameshift; Positions=173; Evidence={ECO:0000305}; Sequence=AAK15708.1; Type=Erroneous termination; Positions=188; Note=Translated as Sec.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SELENOS Gene

neXtProt entry for SELENOS Gene

Post-translational modifications for SELENOS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SELENOS Gene

No data available for DME Specific Peptides for SELENOS Gene

Domains & Families for SELENOS Gene

Gene Families for SELENOS Gene

Protein Domains for SELENOS Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SELENOS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BQE4

UniProtKB/Swiss-Prot:

SELS_HUMAN :
  • Belongs to the selenoprotein S family.
Family:
  • Belongs to the selenoprotein S family.
genes like me logo Genes that share domains with SELENOS: view

Function for SELENOS Gene

Molecular function for SELENOS Gene

UniProtKB/Swiss-Prot Function:
Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.

Gene Ontology (GO) - Molecular Function for SELENOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity NAS 15215856
GO:0005515 protein binding IPI 15215856
GO:0016209 antioxidant activity IDA 15063746
GO:0019899 enzyme binding IPI 15215856
GO:0051117 ATPase binding IPI 24424410
genes like me logo Genes that share ontologies with SELENOS: view
genes like me logo Genes that share phenotypes with SELENOS: view

Animal Model Products

miRNA for SELENOS Gene

miRTarBase miRNAs that target SELENOS

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SELENOS Gene

Localization for SELENOS Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELENOS Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Cytoplasm.

Gene Ontology (GO) - Cellular Components for SELENOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IDA,TAS 16186510
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005881 cytoplasmic microtubule IDA 23264731
GO:0005886 plasma membrane TAS 12663463
genes like me logo Genes that share ontologies with SELENOS: view

No data available for Subcellular locations from COMPARTMENTS for SELENOS Gene

Pathways & Interactions for SELENOS Gene

genes like me logo Genes that share pathways with SELENOS: view

Pathways by source for SELENOS Gene

1 GeneTex pathway for SELENOS Gene
2 BioSystems pathways for SELENOS Gene
1 KEGG pathway for SELENOS Gene

Gene Ontology (GO) - Biological Process for SELENOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus IMP 18675776
GO:0006111 regulation of gluconeogenesis TAS 12663463
GO:0006886 intracellular protein transport IEA --
GO:0006983 ER overload response IMP 17210132
GO:0009749 response to glucose IEP 12031974
genes like me logo Genes that share ontologies with SELENOS: view

No data available for SIGNOR curated interactions for SELENOS Gene

Drugs & Compounds for SELENOS Gene

(2) Drugs for SELENOS Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenocysteine Experimental Pharma 0
Selenium Pharma 175
genes like me logo Genes that share compounds with SELENOS: view

Transcripts for SELENOS Gene

Unigene Clusters for SELENOS Gene

VCP-interacting membrane protein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELENOS Gene

No ASD Table

Relevant External Links for SELENOS Gene

GeneLoc Exon Structure for
SELENOS
ECgene alternative splicing isoforms for
SELENOS

Expression for SELENOS Gene

NURSA nuclear receptor signaling pathways regulating expression of SELENOS Gene:

SELENOS

SOURCE GeneReport for Unigene cluster for SELENOS Gene:

Hs.32148
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SELENOS Gene

Orthologs for SELENOS Gene

This gene was present in the common ancestor of chordates.

Orthologs for SELENOS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VIMP 34
  • 98.94 (n)
SELS 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VIMP 34 35
  • 89.42 (n)
cow
(Bos Taurus)
Mammalia VIMP 34 35
  • 87.83 (n)
rat
(Rattus norvegicus)
Mammalia Vimp 34
  • 85.03 (n)
mouse
(Mus musculus)
Mammalia Vimp 34 16 35
  • 84.85 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia VIMP 35
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VIMP 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves VIMP 34 35
  • 69.44 (n)
lizard
(Anolis carolinensis)
Reptilia VIMP 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vimp 34
  • 57.52 (n)
Str.11154 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.14257 34
zebrafish
(Danio rerio)
Actinopterygii vimp 34 35
  • 56.32 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7106 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
OneToOne
Species where no ortholog for SELENOS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SELENOS Gene

ENSEMBL:
Gene Tree for SELENOS (if available)
TreeFam:
Gene Tree for SELENOS (if available)

Paralogs for SELENOS Gene

No data available for Paralogs for SELENOS Gene

Variants for SELENOS Gene

Sequence variations from dbSNP and Humsavar for SELENOS Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10577938 -- 101,271,732(+) AAGGT(-/TAA)TGTTT intron-variant, downstream-variant-500B
rs111301633 -- 101,273,231(+) AGATT(-/A)AAAAA intron-variant
rs111368856 -- 101,275,974(+) TGGAG(G/T)GCAGT intron-variant
rs111733455 -- 101,272,609(+) ATCTA(C/T)ACCTT intron-variant, utr-variant-3-prime
rs112097458 -- 101,270,531(+) GAACT(C/T)CTGAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SELENOS Gene

Variant ID Type Subtype PubMed ID
dgv2672n100 CNV gain 25217958
dgv2673n100 CNV gain 25217958
esv2760063 CNV gain+loss 17122850
esv34275 CNV gain 17911159
esv3637501 CNV gain 21293372
nsv1035599 CNV gain 25217958
nsv1049577 CNV gain 25217958
nsv428314 CNV loss 18775914
nsv570828 CNV gain 21841781
nsv570833 CNV loss 21841781
nsv833110 CNV gain+loss 17160897

Variation tolerance for SELENOS Gene

Residual Variation Intolerance Score: 79.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.39; 54.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELENOS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELENOS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELENOS Gene

Disorders for SELENOS Gene

MalaCards: The human disease database

(1) MalaCards diseases for SELENOS Gene - From: DISEASES

Disorder Aliases PubMed IDs
pontocerebellar hypoplasia type 2d
  • pontocerebellar hypoplasia 2d
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SELENOS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENOS
genes like me logo Genes that share disorders with SELENOS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SELENOS Gene

Publications for SELENOS Gene

  1. Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. (PMID: 16186510) Ye Y. … Rapoport T.A. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3 4 64
  2. Genetic variation in selenoprotein S influences inflammatory response. (PMID: 16227999) Curran J.E. … Blangero J. (Nat. Genet. 2005) 2 3 22 64
  3. A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. (PMID: 15215856) Ye Y. … Rapoport T.A. (Nature 2004) 2 3 4 64
  4. Influence of SelS gene silence on beta-Mercaptoethanol-mediated endoplasmic reticulum stress and cell apoptosis in HepG2 cells. (PMID: 20114070) Du S. … Huang K. (Biochim. Biophys. Acta 2010) 3 22 64
  5. Genetic variants in selenoprotein genes increase risk of colorectal cancer. (PMID: 20378690) MAcplan C. … Hesketh J.E. (Carcinogenesis 2010) 3 22 64

Products for SELENOS Gene

Sources for SELENOS Gene

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