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Aliases for SELENOP Gene

Aliases for SELENOP Gene

  • Selenoprotein P 2 3 5
  • Selenoprotein P, Plasma, 1 2 3
  • SEPP1 3 4
  • SELP 3 4
  • SEP 3 4
  • SEPP 3

External Ids for SELENOP Gene

Previous HGNC Symbols for SELENOP Gene

  • SEPP1

Summaries for SELENOP Gene

Entrez Gene Summary for SELENOP Gene

  • This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in human), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2017]

GeneCards Summary for SELENOP Gene

SELENOP (Selenoprotein P) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network.

UniProtKB/Swiss-Prot for SELENOP Gene

  • Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis.

Gene Wiki entry for SELENOP Gene

Additional gene information for SELENOP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELENOP Gene

Genomics for SELENOP Gene

Regulatory Elements for SELENOP Gene

Enhancers for SELENOP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H042807 1.3 Ensembl ENCODE 11 +76.6 76602 7 FOXA2 MLX ZFP64 ARID4B DMAP1 YY1 PAF1 SP3 MXD4 REST CCDC152 SELENOP PPIAP77 GHR LOC648987 ENSG00000272234
GH05H042839 1 Ensembl ENCODE 11.4 +46.9 46908 1 ELF3 FOXA2 ZNF792 TAL1 MAX CEBPG ZNF644 RAD21 YY1 ZNF316 SELENOP PPIAP77 GHR ENSG00000272234
GH05H042850 0.9 ENCODE 11.6 +33.8 33830 5 ELF3 FOXA2 FEZF1 RAD21 RARA YY1 TCF12 GATA2 ZNF350 MIXL1 CCDC152 SELENOP PPIAP77 GHR ENSG00000272234
GH05H042837 0.4 FANTOM5 22.7 +49.6 49614 0 YY1 SELENOP PPIAP77 GHR ENSG00000272234
GH05H042806 0.5 ENCODE 10.8 +81.0 80980 0 ZFHX2 POLR2A ZNF512 EGR2 CCDC152 SELENOP PPIAP77 GHR ENSG00000272234
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SELENOP on UCSC Golden Path with GeneCards custom track

Genomic Location for SELENOP Gene

Chromosome:
5
Start:
42,799,880 bp from pter
End:
42,887,392 bp from pter
Size:
87,513 bases
Orientation:
Minus strand

Genomic View for SELENOP Gene

Genes around SELENOP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELENOP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELENOP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELENOP Gene

Proteins for SELENOP Gene

  • Protein details for SELENOP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49908-SEPP1_HUMAN
    Recommended name:
    Selenoprotein P
    Protein Accession:
    P49908
    Secondary Accessions:
    • Q6PD59
    • Q6PI43
    • Q6PI87
    • Q6PJF9

    Protein attributes for SELENOP Gene

    Size:
    381 amino acids
    Molecular mass:
    43174 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SELENOP Gene

Post-translational modifications for SELENOP Gene

  • Phosphorylation sites are present in the extracellular medium.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SELENOP Gene

No data available for DME Specific Peptides for SELENOP Gene

Domains & Families for SELENOP Gene

Gene Families for SELENOP Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for SELENOP Gene

Suggested Antigen Peptide Sequences for SELENOP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49908

UniProtKB/Swiss-Prot:

SEPP1_HUMAN :
  • Belongs to the selenoprotein P family.
Family:
  • Belongs to the selenoprotein P family.
genes like me logo Genes that share domains with SELENOP: view

Function for SELENOP Gene

Molecular function for SELENOP Gene

UniProtKB/Swiss-Prot Function:
Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis.

Gene Ontology (GO) - Molecular Function for SELENOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008430 selenium binding TAS,IEA --
genes like me logo Genes that share ontologies with SELENOP: view
genes like me logo Genes that share phenotypes with SELENOP: view

Animal Models for SELENOP Gene

MGI Knock Outs for SELENOP:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SELENOP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SELENOP Gene

Localization for SELENOP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELENOP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELENOP gene
Compartment Confidence
extracellular 5
plasma membrane 1
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SELENOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031089 platelet dense granule lumen TAS --
genes like me logo Genes that share ontologies with SELENOP: view

Pathways & Interactions for SELENOP Gene

genes like me logo Genes that share pathways with SELENOP: view

Gene Ontology (GO) - Biological Process for SELENOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001887 selenium compound metabolic process IEA --
GO:0002576 platelet degranulation TAS --
GO:0006979 response to oxidative stress TAS 2037562
GO:0007420 brain development IEA --
GO:0007626 locomotory behavior IEA --
genes like me logo Genes that share ontologies with SELENOP: view

No data available for SIGNOR curated interactions for SELENOP Gene

Drugs & Compounds for SELENOP Gene

(9) Drugs for SELENOP Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenium Approved, Vet_approved Pharma 185
Zinc Approved Pharma Target 2359
Selenocysteine Experimental Pharma 0

(13) Additional Compounds for SELENOP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SELENOP: view

Transcripts for SELENOP Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SELENOP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SELENOP Gene

No ASD Table

Relevant External Links for SELENOP Gene

GeneLoc Exon Structure for
SELENOP
ECgene alternative splicing isoforms for
SELENOP

Expression for SELENOP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of SELENOP Gene:

SELENOP

mRNA Expression by UniProt/SwissProt for SELENOP Gene:

P49908-SEPP1_HUMAN
Tissue specificity: Made in the liver and heart and secreted into the plasma. It is also found in the kidney.

Evidence on tissue expression from TISSUES for SELENOP Gene

  • Liver(4.4)
  • Nervous system(4.3)
  • Heart(4.2)
  • Bone marrow(4)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with SELENOP: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SELENOP Gene

Orthologs for SELENOP Gene

This gene was present in the common ancestor of chordates.

Orthologs for SELENOP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEPP1 33
  • 99.13 (n)
dog
(Canis familiaris)
Mammalia SEPP1 33 34
  • 85.29 (n)
cow
(Bos Taurus)
Mammalia SEPP1 33
  • 83.2 (n)
rat
(Rattus norvegicus)
Mammalia Sepp1 33
  • 79.32 (n)
mouse
(Mus musculus)
Mammalia Sepp1 33 34
  • 77.78 (n)
Selenop 16
platypus
(Ornithorhynchus anatinus)
Mammalia SEPP1 34
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEPP1 34
  • 31 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEPP1 33 34
  • 63.7 (n)
lizard
(Anolis carolinensis)
Reptilia SEPP1 34
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sepp1 33
  • 61.3 (n)
Str.5371 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.28822 33
zebrafish
(Danio rerio)
Actinopterygii sepp1a 33 34
  • 51.34 (n)
Species where no ortholog for SELENOP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SELENOP Gene

ENSEMBL:
Gene Tree for SELENOP (if available)
TreeFam:
Gene Tree for SELENOP (if available)

Paralogs for SELENOP Gene

No data available for Paralogs for SELENOP Gene

Variants for SELENOP Gene

Sequence variations from dbSNP and Humsavar for SELENOP Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000553014 -- 42,809,359(+) ATCCT(C/T)AAAAC intron-variant
rs1000650294 -- 42,800,588(+) AAGCC(A/T)ATTCA utr-variant-3-prime
rs1000901689 -- 42,809,703(+) ATATA(A/G)ATAGA intron-variant
rs1001221319 -- 42,805,880(+) AAAAA(A/G)ATAAA intron-variant
rs1001264312 -- 42,813,450(+) GTCAT(C/G)TACCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SELENOP Gene

Variant ID Type Subtype PubMed ID
dgv5637n100 CNV gain 25217958
nsv462126 CNV gain 19166990
nsv523033 CNV gain 19592680
nsv597886 CNV gain 21841781
nsv597925 CNV gain 21841781

Variation tolerance for SELENOP Gene

Residual Variation Intolerance Score: 84.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.03; 75.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELENOP Gene

Human Gene Mutation Database (HGMD)
SELENOP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELENOP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELENOP Gene

Disorders for SELENOP Gene

Relevant External Links for SELENOP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENOP

No disorders were found for SELENOP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SELENOP Gene

Publications for SELENOP Gene

  1. Selenoprotein P: properties, functions, and regulation. (PMID: 10775431) Mostert V (Archives of biochemistry and biophysics 2000) 3 4 22 60
  2. A novel method for the purification of selenoprotein P from human plasma. (PMID: 9735174) Mostert V … Abel J (Archives of biochemistry and biophysics 1998) 3 4 22 60
  3. Purification of selenoprotein P from human plasma. (PMID: 8142465) Akesson B … Burk RF (Biochimica et biophysica acta 1994) 3 4 22 60
  4. Selenoprotein P. A selenium-rich extracellular glycoprotein. (PMID: 7931697) Burk RF … Hill KE (The Journal of nutrition 1994) 3 4 22 60
  5. Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA. (PMID: 8421687) Hill KE … Burk RF (Proceedings of the National Academy of Sciences of the United States of America 1993) 2 3 4 60

Products for SELENOP Gene

Sources for SELENOP Gene

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