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Aliases for SELENOO Gene

Aliases for SELENOO Gene

  • Selenoprotein O 2 3 5
  • SELO 3

External Ids for SELENOO Gene

Summaries for SELENOO Gene

Entrez Gene Summary for SELENOO Gene

  • This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]

GeneCards Summary for SELENOO Gene

SELENOO (Selenoprotein O) is a Protein Coding gene. Diseases associated with SELENOO include Commensal Bacterial Infectious Disease. Among its related pathways are Folate Metabolism and Selenium Metabolism and Selenoproteins.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELENOO Gene

Genomics for SELENOO Gene

Regulatory Elements for SELENOO Gene

Enhancers for SELENOO Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F050199 0.2 ENCODE 21.4 +0.1 51 2.9 ATF1 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 FOS SP3 LOC101928719 SELENOO TUBGCP6 HDAC10 MAPK12 MAPK11 PLXNB2 MLC1 TRABD ALG12
GH22F050204 1.2 Ensembl ENCODE 19.3 +4.1 4101 1.4 KLF17 YY1 ZNF791 ZBTB48 HNF4G NFE2 ZNF600 ZBTB20 EZH2 ZNF263 ALG12 SELENOO ENSG00000273192 TRABD HDAC10 PANX2 ENSG00000272836
GH22F050205 0.2 ENCODE 19.1 +5.5 5456 1.0 CTCF L3MBTL2 ZBTB7A ZNF2 RAD21 ZNF623 NR2F2 YY1 OSR2 ZFHX2 SELENOO LOC105373095 HDAC10 ENSG00000272836
GH22F050219 0.7 ENCODE 17.4 +18.6 18633 1.2 HDAC1 KLF1 MAX ZIC2 CCNT2 POLR2A PRDM10 KLF7 E2F6 ZNF263 LOC101928719 SELENOO MLC1 LOC105373095 TUBGCP6
GH22F050183 1.2 FANTOM5 ENCODE 16.7 -15.2 -15156 3.9 ATF1 ARID4B DMAP1 ZNF48 ZNF2 YY1 ZNF121 GTF3C2 GLIS2 ZNF143 ALG12 TRABD LOC105373095 SELENOO ZBED4 LOC101928719 ENSG00000273192 ENSG00000272836 LOC100420885 PANX2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SELENOO on UCSC Golden Path with GeneCards custom track

Promoters for SELENOO Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001533506 221 2401 ATF1 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 FOS SP3

Genomic Location for SELENOO Gene

Chromosome:
22
Start:
50,200,979 bp from pter
End:
50,217,616 bp from pter
Size:
16,638 bases
Orientation:
Plus strand

Genomic View for SELENOO Gene

Genes around SELENOO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELENOO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELENOO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELENOO Gene

Proteins for SELENOO Gene

  • Protein details for SELENOO Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A087X0Q9
    Recommended name:
    Selenoprotein O
    Protein Accession:
    A0A087X0Q9

    Protein attributes for SELENOO Gene

    Size:
    668 amino acids
    Molecular mass:
    73339 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SELENOO Gene

Post-translational modifications for SELENOO Gene

No Post-translational modifications

Other Protein References for SELENOO Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SELENOO Gene

Domains & Families for SELENOO Gene

Gene Families for SELENOO Gene

Protein Domains for SELENOO Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SELENOO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SELENOO: view

No data available for UniProtKB/Swiss-Prot for SELENOO Gene

Function for SELENOO Gene

genes like me logo Genes that share phenotypes with SELENOO: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SELENOO Gene

Localization for SELENOO Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SELENOO Gene

Pathways & Interactions for SELENOO Gene

genes like me logo Genes that share pathways with SELENOO: view

Pathways by source for SELENOO Gene

2 BioSystems pathways for SELENOO Gene

Interacting Proteins for SELENOO Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000370288%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000225396%0d%0a9606.ENSP00000308022%0d%0a9606.ENSP00000357048%0d%0a
Selected Interacting proteins: ENSP00000370288 for SELENOO Gene via STRING

Gene Ontology (GO) - Biological Process for SELENOO Gene

None

No data available for SIGNOR curated interactions for SELENOO Gene

Transcripts for SELENOO Gene

mRNA/cDNA for SELENOO Gene

Unigene Clusters for SELENOO Gene

Selenoprotein O:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELENOO Gene

No ASD Table

Relevant External Links for SELENOO Gene

GeneLoc Exon Structure for
SELENOO
ECgene alternative splicing isoforms for
SELENOO

Expression for SELENOO Gene

SOURCE GeneReport for Unigene cluster for SELENOO Gene:

Hs.365405
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SELENOO Gene

Orthologs for SELENOO Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SELENOO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 98 (a)
OneToOne
SELO 34
  • 97.24 (n)
dog
(Canis familiaris)
Mammalia SELO 34
  • 85.36 (n)
-- 35
  • 81 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SELO 34 35
  • 84.06 (n)
mouse
(Mus musculus)
Mammalia Selo 34 16 35
  • 80.09 (n)
rat
(Rattus norvegicus)
Mammalia Selo 34
  • 80.06 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves SELO 34 35
  • 70.7 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia selo 34
  • 63.85 (n)
zebrafish
(Danio rerio)
Actinopterygii selo 34 35
  • 60.5 (n)
si:dkey-14d8.2 35
  • 51 (a)
OneToMany
wufd10b07 34
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FMP40 35
  • 25 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G13030 34
  • 48.83 (n)
soybean
(Glycine max)
eudicotyledons Gma.1585 34
rice
(Oryza sativa)
Liliopsida Os06g0320700 34
  • 51.05 (n)
Os.9272 34
barley
(Hordeum vulgare)
Liliopsida Hv.5200 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 51 (a)
OneToOne
Species where no ortholog for SELENOO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SELENOO Gene

ENSEMBL:
Gene Tree for SELENOO (if available)
TreeFam:
Gene Tree for SELENOO (if available)

Paralogs for SELENOO Gene

No data available for Paralogs for SELENOO Gene

Variants for SELENOO Gene

Sequence variations from dbSNP and Humsavar for SELENOO Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs387907019 Pathogenic 50,217,738(-) ACGCC(C/G/T)GAGGC nc-transcript-variant, downstream-variant-500B, reference, stop-lost
rs201721812 Uncertain significance 50,218,001(+) CCCGC(A/G)GGCCC nc-transcript-variant, downstream-variant-500B, reference, missense
rs35231253 Uncertain significance 50,218,105(+) TTCTC(C/T)GTGAG nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon
rs374204240 Uncertain significance 50,217,959(+) TGTAG(A/C/G)ACTGC nc-transcript-variant, downstream-variant-500B, reference, missense
rs1009610 -- 50,200,524(+) CACAG(A/G)TCCAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SELENOO Gene

Variant ID Type Subtype PubMed ID
dgv781n67 CNV gain 20364138
nsv1122059 CNV deletion 24896259
nsv1150959 CNV insertion 26484159
nsv471223 CNV loss 18288195
nsv829333 CNV gain 20364138
nsv955199 CNV deletion 24416366

Variation tolerance for SELENOO Gene

Residual Variation Intolerance Score: 66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.12; 61.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELENOO Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELENOO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELENOO Gene

Disorders for SELENOO Gene

MalaCards: The human disease database

(1) MalaCards diseases for SELENOO Gene - From: DISEASES

Disorder Aliases PubMed IDs
commensal bacterial infectious disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SELENOO

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENOO
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENOO
genes like me logo Genes that share disorders with SELENOO: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SELENOO Gene

Publications for SELENOO Gene

  1. A novel protein kinase-like domain in a selenoprotein, widespread in the tree of life. (PMID: 22359664) Dudkiewicz M. … PawA8owski K. (PLoS ONE 2012) 2 3 64
  2. Characterization of mammalian selenoproteomes. (PMID: 12775843) Kryukov G.V. … Gladyshev V.N. (Science 2003) 2 3 64
  3. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Characterization of mammalian selenoprotein o: a redox-active mitochondrial protein. (PMID: 24751718) Han S.J. … Lee S.R. (PLoS ONE 2014) 3 64

Products for SELENOO Gene

Sources for SELENOO Gene

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