Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SELENOO Gene

Aliases for SELENOO Gene

  • Selenoprotein O 2 3 5
  • SELO 3 4

External Ids for SELENOO Gene

Summaries for SELENOO Gene

Entrez Gene Summary for SELENOO Gene

  • This gene encodes a selenoprotein that is localized to the mitochondria. It is the largest mammalian selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The exact function of this selenoprotein is not known, but it is thought to have redox activity. [provided by RefSeq, Dec 2016]

GeneCards Summary for SELENOO Gene

SELENOO (Selenoprotein O) is a Protein Coding gene. Among its related pathways are Selenium Micronutrient Network and Selenium Metabolism and Selenoproteins.

UniProtKB/Swiss-Prot for SELENOO Gene

  • May be a redox-active mitochondrial selenoprotein which interacts with a redox target protein.

Additional gene information for SELENOO Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELENOO Gene

Genomics for SELENOO Gene

Regulatory Elements for SELENOO Gene

Enhancers for SELENOO Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H050183 1.6 FANTOM5 ENCODE dbSUPER 16.7 -15.2 -15156 3 ARID4B DMAP1 ZNF2 ZNF121 GTF3C2 GLIS2 ZNF143 KLF7 RUNX3 SP3 TRABD BRD1 LOC105373095 SELENOO ZBED4 ALG12 ENSG00000273253 CHKB PLXNB2 LMF2
GH22H050199 1.2 ENCODE dbSUPER 21.4 +0.1 51 2 PKNOX1 ATF1 FOXA2 ARID4B YY1 GLIS2 ZNF143 FOS RUNX3 SP3 ENSG00000273253 SELENOO TUBGCP6 HDAC10 MAPK12 MAPK11 PLXNB2 MLC1 TRABD PANX2
GH22H049932 1.8 FANTOM5 ENCODE dbSUPER 13 -264.7 -264677 6 MLX ARID4B DMAP1 YY1 FOS SP3 SP5 NFYC REST SMARCB1 PIM3 LOC105377205 SELENOO MLC1 ALG12 CRELD2 PANX2 HDAC10 BRD1 TRABD
GH22H050204 1.2 Ensembl ENCODE dbSUPER 19.3 +4.1 4101 1 TAF1 HLF MAFG MAX REST RAD21 YY1 JUND ZNF791 ATF3 SELENOO ALG12 PLXNB2 HDAC10 PANX2 ENSG00000272836
GH22H050243 1.4 ENCODE dbSUPER 15.6 +44.3 44291 3 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 MAPK12 SELENOO RABL2B LOC105377205 MLC1 TUBGCP6 HDAC10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SELENOO on UCSC Golden Path with GeneCards custom track

Promoters for SELENOO Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000147692 121 1801 TBP PKNOX1 ATF1 FOXA2 KLF17 ZBTB40 GLIS2 ZNF143 FOS RUNX3

Genomic Location for SELENOO Gene

Chromosome:
22
Start:
50,200,979 bp from pter
End:
50,217,616 bp from pter
Size:
16,638 bases
Orientation:
Plus strand

Genomic View for SELENOO Gene

Genes around SELENOO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELENOO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELENOO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELENOO Gene

Proteins for SELENOO Gene

  • Protein details for SELENOO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVL4-SELO_HUMAN
    Recommended name:
    Selenoprotein O
    Protein Accession:
    Q9BVL4
    Secondary Accessions:
    • Q2TAL2
    • Q5JZ81
    • Q8WUI0

    Protein attributes for SELENOO Gene

    Size:
    669 amino acids
    Molecular mass:
    73489 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH01099.3; Type=Erroneous termination; Positions=667; Note=Translated as Sec.; Evidence={ECO:0000305}; Sequence=AAH20510.1; Type=Erroneous termination; Positions=667; Note=Translated as Sec.; Evidence={ECO:0000305};

neXtProt entry for SELENOO Gene

Post-translational modifications for SELENOO Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SELENOO Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SELENOO Gene

Domains & Families for SELENOO Gene

Gene Families for SELENOO Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for SELENOO Gene

Suggested Antigen Peptide Sequences for SELENOO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BVL4

UniProtKB/Swiss-Prot:

SELO_HUMAN :
  • Belongs to the UPF0061 (SELO) family.
Family:
  • Belongs to the UPF0061 (SELO) family.
genes like me logo Genes that share domains with SELENOO: view

Function for SELENOO Gene

Molecular function for SELENOO Gene

UniProtKB/Swiss-Prot Function:
May be a redox-active mitochondrial selenoprotein which interacts with a redox target protein.

Phenotypes From GWAS Catalog for SELENOO Gene

genes like me logo Genes that share phenotypes with SELENOO: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SELENOO Gene

Localization for SELENOO Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELENOO Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELENOO gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 2
extracellular 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SELENOO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 24751718
genes like me logo Genes that share ontologies with SELENOO: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SELENOO Gene

Pathways & Interactions for SELENOO Gene

genes like me logo Genes that share pathways with SELENOO: view

Pathways by source for SELENOO Gene

Gene Ontology (GO) - Biological Process for SELENOO Gene

None

No data available for SIGNOR curated interactions for SELENOO Gene

Drugs & Compounds for SELENOO Gene

No Compound Related Data Available

Transcripts for SELENOO Gene

mRNA/cDNA for SELENOO Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELENOO Gene

No ASD Table

Relevant External Links for SELENOO Gene

GeneLoc Exon Structure for
SELENOO
ECgene alternative splicing isoforms for
SELENOO

Expression for SELENOO Gene

Evidence on tissue expression from TISSUES for SELENOO Gene

  • Liver(4.4)
  • Intestine(4.2)
  • Nervous system(4.2)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SELENOO Gene

Orthologs for SELENOO Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SELENOO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 98 (a)
OneToOne
SELO 33
  • 97.24 (n)
dog
(Canis familiaris)
Mammalia SELO 33
  • 85.36 (n)
-- 34
  • 81 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SELO 33 34
  • 84.06 (n)
mouse
(Mus musculus)
Mammalia Selo 33 34
  • 80.09 (n)
Selenoo 16
rat
(Rattus norvegicus)
Mammalia Selo 33
  • 80.06 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves SELO 33 34
  • 70.7 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia selo 33
  • 63.85 (n)
zebrafish
(Danio rerio)
Actinopterygii selo 33 34
  • 60.5 (n)
si:dkey-14d8.2 34
  • 51 (a)
OneToMany
wufd10b07 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FMP40 34
  • 25 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G13030 33
  • 48.83 (n)
soybean
(Glycine max)
eudicotyledons Gma.1585 33
rice
(Oryza sativa)
Liliopsida Os06g0320700 33
  • 51.05 (n)
Os.9272 33
barley
(Hordeum vulgare)
Liliopsida Hv.5200 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 51 (a)
OneToOne
Species where no ortholog for SELENOO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SELENOO Gene

ENSEMBL:
Gene Tree for SELENOO (if available)
TreeFam:
Gene Tree for SELENOO (if available)

Paralogs for SELENOO Gene

No data available for Paralogs for SELENOO Gene

Variants for SELENOO Gene

Sequence variations from dbSNP and Humsavar for SELENOO Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs387907019 Pathogenic 50,217,738(-) ACGCC(C/G/T)GAGGC nc-transcript-variant, downstream-variant-500B, reference, stop-lost
rs138609686 Uncertain significance 50,217,807(+) GCCGC(A/G)GTTCA nc-transcript-variant, downstream-variant-500B, reference, missense
rs201721812 Uncertain significance 50,218,001(+) CCCGC(A/G)GGCCC nc-transcript-variant, downstream-variant-500B, reference, missense
rs35231253 Uncertain significance 50,218,105(+) TTCTC(C/T)GTGAG nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon
rs374204240 Uncertain significance 50,217,959(+) TGTAG(A/C/G)ACTGC nc-transcript-variant, downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SELENOO Gene

Variant ID Type Subtype PubMed ID
dgv781n67 CNV gain 20364138
nsv1122059 CNV deletion 24896259
nsv1150959 CNV insertion 26484159
nsv471223 CNV loss 18288195
nsv829333 CNV gain 20364138
nsv955199 CNV deletion 24416366

Variation tolerance for SELENOO Gene

Residual Variation Intolerance Score: 66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.12; 61.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELENOO Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELENOO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELENOO Gene

Disorders for SELENOO Gene

Relevant External Links for SELENOO

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENOO
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENOO

No disorders were found for SELENOO Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SELENOO Gene

Publications for SELENOO Gene

  1. Characterization of mammalian selenoproteomes. (PMID: 12775843) Kryukov GV … Gladyshev VN (Science (New York, N.Y.) 2003) 2 3 4 60
  2. Selenoprotein Gene Nomenclature. (PMID: 27645994) Gladyshev VN … Zhang Y (The Journal of biological chemistry 2016) 3 4 60
  3. Characterization of mammalian selenoprotein o: a redox-active mitochondrial protein. (PMID: 24751718) Han SJ … Lee SR (PloS one 2014) 3 4 60
  4. A novel protein kinase-like domain in a selenoprotein, widespread in the tree of life. (PMID: 22359664) Dudkiewicz M … Pawłowski K (PloS one 2012) 2 3 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for SELENOO Gene

Sources for SELENOO Gene

Content
Loading form....