Aliases for SELENON Gene
Aliases for SELENON Gene
External Ids for SELENON Gene
- HGNC: 15999
- Entrez Gene: 57190
- Ensembl: ENSG00000162430
- OMIM: 606210
- UniProtKB: Q9NZV5
Previous HGNC Symbols for SELENON Gene
- RSMD1
- MDRS1
- SEPN1
Summaries for SELENON Gene
-
This gene encodes a glycoprotein that is localized in the endoplasmic reticulum. It plays an important role in cell protection against oxidative stress, and in the regulation of redox-related calcium homeostasis. Mutations in this gene are associated with early onset muscle disorders, referred to as SEPN1-related myopathy. SEPN1-related myopathy consists of 4 autosomal recessive disorders, originally thought to be separate entities: rigid spine muscular dystrophy (RSMD1), the classical form of multiminicore disease, desmin related myopathy with Mallory-body like inclusions, and congenital fiber-type disproportion (CFTD). This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A second stop-codon redefinition element (SRE) adjacent to the UGA codon has been identified in this gene. SRE is a phylogenetically conserved stem-loop structure that stimulates readthrough at the UGA codon, and augments the Sec insertion efficiency by SECIS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2016]
GeneCards Summary for SELENON Gene
SELENON (Selenoprotein N) is a Protein Coding gene. Diseases associated with SELENON include Muscular Dystrophy, Rigid Spine, 1 and Myopathy, Congenital, With Fiber-Type Disproportion. Among its related pathways are Folate Metabolism and Selenium Metabolism and Selenoproteins. An important paralog of this gene is ENSG00000255054.
UniProtKB/Swiss-Prot for SELENON Gene
-
Isoform 2: Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity (PubMed:25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (PubMed:19557870, PubMed:18713863).
-
Essential for muscle regeneration and satellite cell maintenance in skeletal muscle (PubMed:21131290).
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELENON Gene
Genomics for SELENON Gene
Regulatory Elements for SELENON Gene
Enhancers for SELENON Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around SELENON on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for SELENON Gene
- Chromosome:
- 1
- Start:
- 25,800,176 bp from pter
- End:
- 25,818,224 bp from pter
- Size:
- 18,049 bases
- Orientation:
- Plus strand
Genomic View for SELENON Gene
Genes around SELENON on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.11 by Ensembl
- 1p36.11 by Entrez Gene
- 1p36.11 by HGNC
SELENON Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SELENON Gene
Proteins for SELENON Gene
-
Protein details for SELENON Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NZV5-SELN_HUMAN
- Recommended name:
- Selenoprotein N
- Protein Accession:
- Q9NZV5
- A6NJG8
- A8MQ64
- Q6PI70
- Q969F6
- Q9NUI6
Protein attributes for SELENON Gene
- Size:
- 590 amino acids
- Molecular mass:
- 65813 Da
- Quaternary structure:
-
- Isoform 2: Interacts with RYR1, RYR2 and RYR3 (PubMed:18713863).
- SequenceCaution:
-
- Sequence=AAH15638.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH42154.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Post-translational modifications for SELENON Gene
- Isoform 2: N-glycosylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for SELENON Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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Protein Products
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Assay Products
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No data available for DME Specific Peptides for SELENON Gene
Domains & Families for SELENON Gene
Gene Families for SELENON Gene
Protein Domains for SELENON Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SELENON Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NZV5UniProtKB/Swiss-Prot:
SELN_HUMAN :- Isoform 2: The N-terminus (first 61 amino acids) contains an endoplasmic reticulum addressing and retention targeting signal.
- Domain:
-
- Isoform 2: The N-terminus (first 61 amino acids) contains an endoplasmic reticulum addressing and retention targeting signal.
- Contains 1 EF-hand domain.
Function for SELENON Gene
Molecular function for SELENON Gene
- UniProtKB/Swiss-Prot Function:
- Isoform 2: Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity (PubMed:25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (PubMed:19557870, PubMed:18713863).
- UniProtKB/Swiss-Prot Function:
- Essential for muscle regeneration and satellite cell maintenance in skeletal muscle (PubMed:21131290).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 17474147 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
Phenotypes for SELENON Gene
- MGI mutant phenotypes for SELENON:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for SELENON:
-
- Increased vaccinia virus (VACV) infection
- Dynamic nuclei (hole, folded or small irregular)
- Decreased NF-kappaB reporter expression
- Decreased viability with paclitaxel
- Increased cell number in S
- Synthetic lethal with vaccinia virus (VACV) infection
- Decreased viability of wild-type and TP53 knockout cells
Animal Models for SELENON Gene
Animal Model Products
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-
-
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-
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CRISPR Products
-
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miRNA for SELENON Gene
- miRTarBase miRNAs that target SELENON
-
- hsa-mir-193b-3p (MIRT016424)
- hsa-mir-423-5p (MIRT038142)
- hsa-mir-423-3p (MIRT042527)
- hsa-mir-331-3p (MIRT043560)
- hsa-mir-149-5p (MIRT045474)
- hsa-mir-4293 (MIRT066278)
- hsa-mir-3180-5p (MIRT441902)
- hsa-mir-525-5p (MIRT441903)
- hsa-mir-520a-5p (MIRT441904)
- hsa-mir-6845-5p (MIRT441905)
- hsa-mir-6762-5p (MIRT441906)
- hsa-mir-2115-5p (MIRT441907)
- hsa-mir-646 (MIRT441908)
- hsa-mir-4506 (MIRT441909)
- hsa-mir-384 (MIRT653948)
- hsa-mir-6772-3p (MIRT653949)
- hsa-mir-6749-3p (MIRT653950)
- hsa-mir-7975 (MIRT653951)
- hsa-mir-5571-3p (MIRT653952)
- hsa-mir-6802-3p (MIRT653953)
- hsa-mir-4448 (MIRT653954)
- hsa-mir-6837-3p (MIRT653955)
- hsa-mir-4268 (MIRT653956)
- hsa-mir-6754-3p (MIRT653957)
- hsa-mir-412-3p (MIRT653958)
- hsa-mir-4469 (MIRT653959)
- hsa-mir-136-5p (MIRT653960)
- hsa-mir-4667-3p (MIRT653961)
- hsa-mir-1470 (MIRT653962)
- hsa-mir-596 (MIRT653963)
miRNA Products
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Inhibitory RNA Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for SELENON
-
ViGene Biosciences adenoviral particle packaged cDNA for SELENON gene
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SELENON Gene
Localization for SELENON Gene
Subcellular locations from UniProtKB/Swiss-Prot for SELENON Gene
- Isoform 2: Endoplasmic reticulum membrane.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| plasma membrane | 2 |
| cytosol | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005789 | endoplasmic reticulum membrane | IDA | 12700173 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for SELENON Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Selenium Metabolism and Selenoproteins | ||
| 2 | Folate Metabolism |
.44
|
|
Pathways by source for SELENON Gene
2 BioSystems pathways for SELENON Gene
Interacting Proteins for SELENON Gene
Selected Interacting proteins:
ENSP00000355141
Q9NZV5-SELN_HUMAN
for SELENON Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007005 | mitochondrion organization | IEA | -- |
| GO:0008150 | biological_process | ND | -- |
| GO:0014816 | skeletal muscle satellite cell differentiation | IEA | -- |
| GO:0014834 | skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration | IEA | -- |
| GO:0014858 | positive regulation of skeletal muscle cell proliferation | IEA | -- |
No data available for SIGNOR curated interactions for SELENON Gene
Transcripts for SELENON Gene
mRNA/cDNA for SELENON Gene
- (2) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (645) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for SELENON
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miRNA Products
- Search ViGene Biosciences for SELENON
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for SELENON
- Browse OriGene Inhibitory RNA Products For SELENON
-
ViGene Biosciences ready-to-package AAV shRNAs for SELENON gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SELENON
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SELENON
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for SELENON Gene
NURSA nuclear receptor signaling pathways regulating expression of SELENON Gene:
SELENONSOURCE GeneReport for Unigene cluster for SELENON Gene:
Hs.323396mRNA Expression by UniProt/SwissProt for SELENON Gene:
Q9NZV5-SELN_HUMAN
Tissue specificity:
Isoform 1 and isoform 2 are expressed in skeletal muscle, brain, lung and placenta. Isoform 2 is also expressed in heart, diaphragm and stomach.
Primer Products
-
OriGene qPCR primer pairs for SELENON
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SELENON Gene
Orthologs for SELENON Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SEPN1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | SEPN1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | SEPN1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Sepn1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Sepn1 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | SEPN1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SEPN1 34 35 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | sepn1 34 |
|
||
| LOC394859 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | sepn1 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.9228 35 |
|
OneToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.13336 34 |
|
- Species where no ortholog for SELENON was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for SELENON Gene
Paralogs for SELENON Gene
Variants for SELENON Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs121908182 | Rigid spine muscular dystrophy 1 (RSMD1) [MIM:602771], Pathogenic | 25,809,096(+) | TCAGG(A/G)AGCTG | reference, missense | |
| rs121908185 | Rigid spine muscular dystrophy 1 (RSMD1) [MIM:602771], Pathogenic | 25,813,890(+) | AGGGC(A/G)GACTC | reference, missense | |
| rs121908186 | Rigid spine muscular dystrophy 1 (RSMD1) [MIM:602771], Pathogenic | 25,812,763(+) | GCTGT(C/G)GGGGG | reference, missense | |
| rs121908187 | Rigid spine muscular dystrophy 1 (RSMD1) [MIM:602771], Pathogenic | 25,812,789(+) | CCTGC(G/T)GAGGT | reference, stop-lost | |
| rs121908188 | Myopathy, congenital, with fiber-type disproportion (CFTD) [MIM:255310], Rigid spine muscular dystrophy 1 (RSMD1) [MIM:602771], Pathogenic | 25,809,753(+) | TCACC(A/G)GCCAC | reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv14e201 | CNV | deletion | 23290073 |
| esv2353706 | CNV | deletion | 18987734 |
| esv2742604 | CNV | deletion | 23290073 |
| esv2745652 | CNV | deletion | 23290073 |
| nsv460884 | CNV | loss | 19166990 |
| nsv545883 | CNV | loss | 21841781 |
| nsv7490 | CNV | deletion | 18451855 |
| nsv834491 | CNV | loss | 17160897 |
| nsv950337 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.65;
56.89% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for SELENON Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SELENON
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELENON Gene
Disorders for SELENON Gene
(17) MalaCards diseases for SELENON Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| muscular dystrophy, rigid spine, 1 |
|
|
| myopathy, congenital, with fiber-type disproportion |
|
|
| congenital fiber-type disproportion |
|
|
| selenon-related multiminicore disease |
|
|
| selenon-related myopathy |
|
|
Search SELENON in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
SELN_HUMAN- Myopathy, congenital, with fiber-type disproportion (CFTD) [MIM:255310]: A genetically heterogeneous disorder in which there is relative hypotrophy of type 1 muscle fibers compared to type 2 fibers on skeletal muscle biopsy. However, these findings are not specific and can be found in many different myopathic and neuropathic conditions. {ECO:0000269 PubMed:16365872}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Rigid spine muscular dystrophy 1 (RSMD1) [MIM:602771]: A neuromuscular disorder characterized by poor axial muscle strength, scoliosis and neck weakness, and a variable degree of spinal rigidity. Early ventilatory insufficiency can lead to death by respiratory failure. {ECO:0000269 PubMed:11528383, ECO:0000269 PubMed:12192640, ECO:0000269 PubMed:15122708, ECO:0000269 PubMed:15668457, ECO:0000269 PubMed:19067361}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for SELENON
No data available for Genatlas for SELENON Gene
Publications for SELENON Gene
- A mutation in the SEPN1 selenocysteine redefinition element (SRE) reduces selenocysteine incorporation and leads to SEPN1-related myopathy. (PMID: 19067361) Maiti B. … Howard M.T. (Hum. Mutat. 2009) 3 4 22 64
- Oxidative stress in SEPN1-related myopathy: from pathophysiology to treatment. (PMID: 19557870) Arbogast S. … Ferreiro A. (Ann. Neurol. 2009) 3 4 22 64
- Desmin-related myopathy with Mallory body-like inclusions is caused by mutations of the selenoprotein N gene. (PMID: 15122708) Ferreiro A. … Bonnemann C.G. (Ann. Neurol. 2004) 3 4 22 64
- Selenoprotein N: an endoplasmic reticulum glycoprotein with an early developmental expression pattern. (PMID: 12700173) Petit N. … Guicheney P. (Hum. Mol. Genet. 2003) 3 4 22 64
- Mutations of the selenoprotein N gene, which is implicated in rigid spine muscular dystrophy, cause the classical phenotype of multiminicore disease: reassessing the nosology of early-onset myopathies. (PMID: 12192640) Ferreiro A. … Guicheney P. (Am. J. Hum. Genet. 2002) 3 4 22 64
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for SELENON Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab