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Aliases for SELENOM Gene

Aliases for SELENOM Gene

  • Selenoprotein M 2 3 5
  • SELM 3 4
  • Selenoprotein SelM 3
  • SEPM 3

External Ids for SELENOM Gene

Summaries for SELENOM Gene

Entrez Gene Summary for SELENOM Gene

  • The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known. It is localized in the perinuclear region, is highly expressed in the brain, and may be involved in neurodegenerative disorders. Transgenic mice with targeted deletion of this gene exhibit increased weight gain, suggesting a role for this gene in the regulation of body weight and energy metabolism. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Dec 2016]

GeneCards Summary for SELENOM Gene

SELENOM (Selenoprotein M) is a Protein Coding gene. Among its related pathways are Selenium Micronutrient Network and Selenium Metabolism and Selenoproteins.

UniProtKB/Swiss-Prot for SELENOM Gene

  • May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation.

Additional gene information for SELENOM Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELENOM Gene

Genomics for SELENOM Gene

Regulatory Elements for SELENOM Gene

Enhancers for SELENOM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H031077 1.6 Ensembl ENCODE dbSUPER 21.7 +37.2 37172 10 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 TUG1 MORC2 SELENOM SMTN SF3A1 INPP5J TBC1D10A PRR14L PES1 DEPDC5
GH22H031097 1.6 Ensembl ENCODE dbSUPER 17.5 +17.0 17018 10 PKNOX1 FOXA2 ARNT ARID4B YY1 ZNF143 FOS DEK SP3 SP5 TUG1 MORC2 RNF185 SELENOM EIF4ENIF1 PATZ1 RNF215 PLA2G3 ENSG00000214125 DEPDC5
GH22H031043 1.4 FANTOM5 Ensembl ENCODE 19.7 +74.3 74333 3 ZNF133 RAD21 SP5 NR2F2 KAT8 ZFP69B NFIC PRDM6 KLF16 KDM1A SELENOM MORC2 TUG1 INPP5J RNU6-1128P SFI1 ENSG00000278920 ENSG00000269987
GH22H031052 1.3 Ensembl ENCODE 17.9 +65.1 65114 4 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 ENSG00000223831 SELENOM MORC2-AS1 INPP5J ENSG00000214125 ENSG00000227813 RN7SL305P LOC105372988 LINC02558 RPS3AP51
GH22H031226 2 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -110.3 -110340 7 HDGF ATF1 FOXA2 MLX ARNT ARID4B YY1 TCF12 ZNF121 ZNF766 LIMK2 RNF185 SFI1 SELENOM INPP5J LINC01521 PATZ1 PIK3IP1 SMTN ENSG00000202019
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SELENOM on UCSC Golden Path with GeneCards custom track

Genomic Location for SELENOM Gene

Chromosome:
22
Start:
31,104,772 bp from pter
End:
31,120,069 bp from pter
Size:
15,298 bases
Orientation:
Minus strand

Genomic View for SELENOM Gene

Genes around SELENOM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELENOM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELENOM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELENOM Gene

Proteins for SELENOM Gene

  • Protein details for SELENOM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWX9-SELM_HUMAN
    Recommended name:
    Selenoprotein M
    Protein Accession:
    Q8WWX9
    Secondary Accessions:
    • A8MPZ2

    Protein attributes for SELENOM Gene

    Size:
    145 amino acids
    Molecular mass:
    16232 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SELENOM Gene

Post-translational modifications for SELENOM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SELENOM Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SELENOM Gene

Domains & Families for SELENOM Gene

Gene Families for SELENOM Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for SELENOM Gene

Suggested Antigen Peptide Sequences for SELENOM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWX9

UniProtKB/Swiss-Prot:

SELM_HUMAN :
  • Belongs to the selenoprotein M/F family.
Family:
  • Belongs to the selenoprotein M/F family.
genes like me logo Genes that share domains with SELENOM: view

Function for SELENOM Gene

Molecular function for SELENOM Gene

UniProtKB/Swiss-Prot Function:
May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation.

Phenotypes From GWAS Catalog for SELENOM Gene

Gene Ontology (GO) - Molecular Function for SELENOM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SELENOM: view
genes like me logo Genes that share phenotypes with SELENOM: view

Animal Models for SELENOM Gene

MGI Knock Outs for SELENOM:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SELENOM
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SELENOM Gene

Localization for SELENOM Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELENOM Gene

Cytoplasm, perinuclear region. Endoplasmic reticulum. Golgi apparatus. Note=Localized to perinuclear structures corresponding to Golgi and endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELENOM gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 3
golgi apparatus 3
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SELENOM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with SELENOM: view

Pathways & Interactions for SELENOM Gene

genes like me logo Genes that share pathways with SELENOM: view

Pathways by source for SELENOM Gene

Interacting Proteins for SELENOM Gene

Gene Ontology (GO) - Biological Process for SELENOM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010269 response to selenium ion IEA --
GO:0035264 multicellular organism growth IEA --
GO:0035934 corticosterone secretion IEA --
GO:0042445 hormone metabolic process IEA --
GO:0060612 adipose tissue development IEA --
genes like me logo Genes that share ontologies with SELENOM: view

No data available for SIGNOR curated interactions for SELENOM Gene

Drugs & Compounds for SELENOM Gene

(2) Drugs for SELENOM Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenium Approved, Vet_approved Pharma 185
Selenocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with SELENOM: view

Transcripts for SELENOM Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SELENOM
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SELENOM Gene

No ASD Table

Relevant External Links for SELENOM Gene

GeneLoc Exon Structure for
SELENOM
ECgene alternative splicing isoforms for
SELENOM

Expression for SELENOM Gene

mRNA Expression by UniProt/SwissProt for SELENOM Gene:

Q8WWX9-SELM_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for SELENOM Gene

  • Nervous system(4.4)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with SELENOM: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SELENOM Gene

Orthologs for SELENOM Gene

This gene was present in the common ancestor of chordates.

Orthologs for SELENOM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SELM 33 34
  • 99.08 (n)
dog
(Canis familiaris)
Mammalia SELM 33
  • 85.4 (n)
mouse
(Mus musculus)
Mammalia Selm 33 34
  • 84.59 (n)
Selenom 16
cow
(Bos Taurus)
Mammalia SELM 33 34
  • 83.88 (n)
rat
(Rattus norvegicus)
Mammalia Selm 33
  • 83.75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves SELM 33 34
  • 75.33 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia selm 33
  • 64.51 (n)
Str.10296 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.16264 33
zebrafish
(Danio rerio)
Actinopterygii selm 33 34
  • 66.67 (n)
sepm 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8755 33
Species where no ortholog for SELENOM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SELENOM Gene

ENSEMBL:
Gene Tree for SELENOM (if available)
TreeFam:
Gene Tree for SELENOM (if available)

Paralogs for SELENOM Gene

No data available for Paralogs for SELENOM Gene

Variants for SELENOM Gene

Sequence variations from dbSNP and Humsavar for SELENOM Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000329869 -- 31,106,739(+) CACCC(G/T)TTTGT intron-variant, upstream-variant-2KB
rs1000942217 -- 31,104,743(+) ACCCC(A/C)CCCGC downstream-variant-500B
rs1001835513 -- 31,107,023(+) GGGGA(A/C)TTCCA intron-variant, upstream-variant-2KB
rs1002377514 -- 31,106,815(+) ACTCC(A/G)AACGG intron-variant, upstream-variant-2KB
rs1002653855 -- 31,106,783(+) TGTGA(C/T)GGTCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SELENOM Gene

Variant ID Type Subtype PubMed ID
nsv1110864 OTHER inversion 24896259
nsv829173 CNV loss 20364138
nsv953069 CNV deletion 24416366
nsv9896 CNV gain 18304495

Variation tolerance for SELENOM Gene

Residual Variation Intolerance Score: 62.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELENOM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELENOM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELENOM Gene

Disorders for SELENOM Gene

Relevant External Links for SELENOM

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENOM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENOM

No disorders were found for SELENOM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SELENOM Gene

Publications for SELENOM Gene

  1. Mammalian selenoprotein in which selenocysteine (Sec) incorporation is supported by a new form of Sec insertion sequence element. (PMID: 11839807) Korotkov KV … Gladyshev VN (Molecular and cellular biology 2002) 2 3 4 22 60
  2. Selenoprotein Gene Nomenclature. (PMID: 27645994) Gladyshev VN … Zhang Y (The Journal of biological chemistry 2016) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for SELENOM Gene

Sources for SELENOM Gene

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