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Aliases for SELENOM Gene

Aliases for SELENOM Gene

  • Selenoprotein M 2 3 5
  • Selenoprotein SelM 3
  • SELM 3
  • SEPM 3

External Ids for SELENOM Gene

Summaries for SELENOM Gene

Entrez Gene Summary for SELENOM Gene

  • The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known. It is localized in the perinuclear region, is highly expressed in the brain, and may be involved in neurodegenerative disorders. Transgenic mice with targeted deletion of this gene exhibit increased weight gain, suggesting a role for this gene in the regulation of body weight and energy metabolism. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Dec 2016]

GeneCards Summary for SELENOM Gene

SELENOM (Selenoprotein M) is a Protein Coding gene. Among its related pathways are Folate Metabolism and Selenium Metabolism and Selenoproteins.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELENOM Gene

Genomics for SELENOM Gene

Regulatory Elements for SELENOM Gene

Enhancers for SELENOM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F031077 1.3 Ensembl ENCODE 21.7 +37.2 37172 10.3 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 SELENOM INPP5J MORC2 TUG1 ENSG00000273387 GC22P031076
GH22F031043 1.4 FANTOM5 Ensembl ENCODE 19.6 +74.3 74333 3.9 ZNF133 ZNF48 RAD21 SCRT2 SP5 NR2F2 KAT8 ZFP69B KLF16 ZNF580 SELENOM MORC2 TUG1 INPP5J RNU6-1128P SFI1 ENSG00000278920 ENSG00000269987
GH22F031097 1.4 Ensembl ENCODE 17.5 +17.0 17018 10.5 HDGF PKNOX1 MLX ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 TUG1 MORC2 SELENOM PLA2G3 ENSG00000214125 RNF185 PRR14L SFI1 INPP5J ENSG00000273387
GH22F031062 1.2 Ensembl ENCODE 19.7 +56.1 56129 1.9 TBP HDAC1 NFRKB ZNF76 SIN3A ARID4B DMAP1 ZNF2 YY1 SCRT2 SELENOM MORC2 INPP5J TUG1 PES1 TCN2 ENSG00000223831 SMTN RN7SL633P
GH22F031052 1.3 Ensembl ENCODE 17.8 +65.1 65114 4.3 PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 FOS ENSG00000223831 SELENOM MORC2-AS1 ENSG00000214125 LOC105372988 RPL36P17 ENSG00000227813 LOC105372999 RPS3AP51 RN7SL305P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SELENOM on UCSC Golden Path with GeneCards custom track

Genomic Location for SELENOM Gene

Chromosome:
22
Start:
31,104,772 bp from pter
End:
31,120,069 bp from pter
Size:
15,298 bases
Orientation:
Minus strand

Genomic View for SELENOM Gene

Genes around SELENOM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELENOM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELENOM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELENOM Gene

Proteins for SELENOM Gene

  • Protein details for SELENOM Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A087WWF1
    Recommended name:
    Selenoprotein M
    Protein Accession:
    A0A087WWF1

    Protein attributes for SELENOM Gene

    Size:
    144 amino acids
    Molecular mass:
    16082 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SELENOM Gene

Post-translational modifications for SELENOM Gene

No Post-translational modifications

Other Protein References for SELENOM Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SELENOM Gene

Domains & Families for SELENOM Gene

Gene Families for SELENOM Gene

Protein Domains for SELENOM Gene

Suggested Antigen Peptide Sequences for SELENOM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SELENOM: view

No data available for UniProtKB/Swiss-Prot for SELENOM Gene

Function for SELENOM Gene

Gene Ontology (GO) - Molecular Function for SELENOM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SELENOM: view
genes like me logo Genes that share phenotypes with SELENOM: view

Animal Models for SELENOM Gene

MGI Knock Outs for SELENOM:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SELENOM Gene

Localization for SELENOM Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELENOM gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 3
golgi apparatus 3
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for SELENOM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with SELENOM: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SELENOM Gene

Pathways & Interactions for SELENOM Gene

genes like me logo Genes that share pathways with SELENOM: view

Pathways by source for SELENOM Gene

2 BioSystems pathways for SELENOM Gene

Interacting Proteins for SELENOM Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000383155%0d%0a9606.ENSP00000392057%0d%0a9606.ENSP00000354929%0d%0a
Selected Interacting proteins: ENSP00000383155 for SELENOM Gene via STRING

Gene Ontology (GO) - Biological Process for SELENOM Gene

None

No data available for SIGNOR curated interactions for SELENOM Gene

Drugs & Compounds for SELENOM Gene

(2) Drugs for SELENOM Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenocysteine Experimental Pharma 0
Selenium Pharma 175
genes like me logo Genes that share compounds with SELENOM: view

Transcripts for SELENOM Gene

Unigene Clusters for SELENOM Gene

Selenoprotein M:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELENOM Gene

No ASD Table

Relevant External Links for SELENOM Gene

GeneLoc Exon Structure for
SELENOM
ECgene alternative splicing isoforms for
SELENOM

Expression for SELENOM Gene

SOURCE GeneReport for Unigene cluster for SELENOM Gene:

Hs.55940
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SELENOM Gene

Orthologs for SELENOM Gene

This gene was present in the common ancestor of chordates.

Orthologs for SELENOM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SELM 34 35
  • 99.08 (n)
dog
(Canis familiaris)
Mammalia SELM 34
  • 85.4 (n)
mouse
(Mus musculus)
Mammalia Selm 34 16 35
  • 84.59 (n)
cow
(Bos Taurus)
Mammalia SELM 34 35
  • 83.88 (n)
rat
(Rattus norvegicus)
Mammalia Selm 34
  • 83.75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves SELM 34 35
  • 75.33 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia selm 34
  • 64.51 (n)
Str.10296 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16264 34
zebrafish
(Danio rerio)
Actinopterygii selm 34 35
  • 66.67 (n)
sepm 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8755 34
Species where no ortholog for SELENOM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SELENOM Gene

ENSEMBL:
Gene Tree for SELENOM (if available)
TreeFam:
Gene Tree for SELENOM (if available)

Paralogs for SELENOM Gene

No data available for Paralogs for SELENOM Gene

Variants for SELENOM Gene

Sequence variations from dbSNP and Humsavar for SELENOM Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs10304 -- 31,104,550(+) CCACC(A/G)CTGCC downstream-variant-500B, utr-variant-3-prime
rs1056455 -- 31,104,526(+) ACCGT(C/T)TCCTG downstream-variant-500B, utr-variant-3-prime
rs111892290 -- 31,105,288(+) GTGAC(A/T)GGAGG splice-acceptor-variant
rs112745491 -- 31,105,657(+) GGATA(A/C/G)TAGAA splice-donor-variant
rs113206389 -- 31,104,622(+) TTCAA(C/G)GATCC downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SELENOM Gene

Variant ID Type Subtype PubMed ID
nsv1110864 OTHER inversion 24896259
nsv829173 CNV loss 20364138
nsv953069 CNV deletion 24416366
nsv9896 CNV gain 18304495

Variation tolerance for SELENOM Gene

Residual Variation Intolerance Score: 62.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELENOM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELENOM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELENOM Gene

Disorders for SELENOM Gene

Relevant External Links for SELENOM

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENOM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENOM

No disorders were found for SELENOM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SELENOM Gene

Publications for SELENOM Gene

  1. Mammalian selenoprotein in which selenocysteine (Sec) incorporation is supported by a new form of Sec insertion sequence element. (PMID: 11839807) Korotkov K.V. … Gladyshev V.N. (Mol. Cell. Biol. 2002) 2 3 22 64
  2. Selenoprotein Gene Nomenclature. (PMID: 27645994) Gladyshev V.N. … Zhang Y. (J. Biol. Chem. 2016) 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Structure-function relationship and evolutionary history of the human selenoprotein M (SelM) found over-expressed in hepatocellular carcinoma. (PMID: 24332979) Guariniello S. … Costantini S. (Biochim. Biophys. Acta 2014) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for SELENOM Gene

Sources for SELENOM Gene

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