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Aliases for SELENOK Gene

Aliases for SELENOK Gene

  • Selenoprotein K 2 3 5
  • HSPC030 3
  • HSPC297 3
  • SELK 3

External Ids for SELENOK Gene

Summaries for SELENOK Gene

Entrez Gene Summary for SELENOK Gene

  • The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced apoptosis. Knockout studies in mice show the importance of this gene in promoting Ca(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Dec 2016]

GeneCards Summary for SELENOK Gene

SELENOK (Selenoprotein K) is a Protein Coding gene. Among its related pathways are Folate Metabolism and Selenium Metabolism and Selenoproteins.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELENOK Gene

Genomics for SELENOK Gene

Regulatory Elements for SELENOK Gene

Enhancers for SELENOK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F053890 0.2 ENCODE 6.6 +0.2 169 2.8 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 ACTR8 RFT1 SELENOK ENSG00000271976
GH03F053747 1.5 FANTOM5 Ensembl ENCODE 2.9 +142.9 142875 3.4 MXI1 EBF1 ZIC2 ETS1 RELA NFYB ETV6 MAZ MTA2 BHLHE40 IL17RB SELENOK DCP1A GC03P053782 PIR47826
GH03F053996 0.2 Ensembl 0.1 -104.6 -104613 0.4 GTF2F1 TBP SMARCC1 STAT1 ZNF680 TAF1 CEBPB MAX RAD21 EP300 LOC105377095 SELENOK
GH03F054026 0.4 ENCODE 0.1 -134.8 -134803 0.8 LOC105377095 SELENOK
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SELENOK on UCSC Golden Path with GeneCards custom track

Promoters for SELENOK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001364539 388 2800 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207

Genomic Location for SELENOK Gene

Chromosome:
3
Start:
53,884,410 bp from pter
End:
53,891,988 bp from pter
Size:
7,579 bases
Orientation:
Minus strand

Genomic View for SELENOK Gene

Genes around SELENOK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELENOK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELENOK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELENOK Gene

Proteins for SELENOK Gene

  • Protein details for SELENOK Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    F6XHT0
    Recommended name:
    Selenoprotein K
    Protein Accession:
    F6XHT0

    Protein attributes for SELENOK Gene

    Size:
    93 amino acids
    Molecular mass:
    10495 Da
    Quaternary structure:
    No Data Available
  • Protein details for SELENOK Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    F8WAX7
    Recommended name:
    Selenoprotein K
    Protein Accession:
    F8WAX7

    Protein attributes for SELENOK Gene

    Size:
    72 amino acids
    Molecular mass:
    8291 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SELENOK Gene

Post-translational modifications for SELENOK Gene

No Post-translational modifications

Other Protein References for SELENOK Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SELENOK Gene

Domains & Families for SELENOK Gene

Gene Families for SELENOK Gene

Protein Domains for SELENOK Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SELENOK Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SELENOK: view

No data available for UniProtKB/Swiss-Prot for SELENOK Gene

Function for SELENOK Gene

Gene Ontology (GO) - Molecular Function for SELENOK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IPI 25117454
genes like me logo Genes that share ontologies with SELENOK: view
genes like me logo Genes that share phenotypes with SELENOK: view

Animal Models for SELENOK Gene

MGI Knock Outs for SELENOK:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SELENOK Gene

Localization for SELENOK Gene

Gene Ontology (GO) - Cellular Components for SELENOK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 16962588
GO:0005789 endoplasmic reticulum membrane IDA 21220695
GO:0005794 Golgi apparatus IBA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SELENOK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for SELENOK Gene

Pathways & Interactions for SELENOK Gene

genes like me logo Genes that share pathways with SELENOK: view

Pathways by source for SELENOK Gene

2 BioSystems pathways for SELENOK Gene

Interacting Proteins for SELENOK Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000418813%0d%0a9606.ENSP00000328182%0d%0a9606.ENSP00000328182%0d%0a
Selected Interacting proteins: ENSP00000418813 for SELENOK Gene via STRING

Gene Ontology (GO) - Biological Process for SELENOK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IBA --
GO:0006816 calcium ion transport IBA --
GO:0006979 response to oxidative stress IMP 16962588
GO:0032469 endoplasmic reticulum calcium ion homeostasis IBA --
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP 20692228
genes like me logo Genes that share ontologies with SELENOK: view

No data available for SIGNOR curated interactions for SELENOK Gene

Drugs & Compounds for SELENOK Gene

(2) Drugs for SELENOK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenocysteine Experimental Pharma 0
Selenium Pharma 175
genes like me logo Genes that share compounds with SELENOK: view

Transcripts for SELENOK Gene

Unigene Clusters for SELENOK Gene

Selenoprotein K:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELENOK Gene

No ASD Table

Relevant External Links for SELENOK Gene

GeneLoc Exon Structure for
SELENOK
ECgene alternative splicing isoforms for
SELENOK

Expression for SELENOK Gene

SOURCE GeneReport for Unigene cluster for SELENOK Gene:

Hs.58471
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SELENOK Gene

Orthologs for SELENOK Gene

This gene was present in the common ancestor of chordates.

Orthologs for SELENOK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SELK 34 35
  • 98.94 (n)
dog
(Canis familiaris)
Mammalia SELK 34
  • 95.04 (n)
cow
(Bos Taurus)
Mammalia SELK 34 35
  • 92.91 (n)
rat
(Rattus norvegicus)
Mammalia Selk 34
  • 89.36 (n)
mouse
(Mus musculus)
Mammalia Selk 34 16 35
  • 89.01 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves SELK 34 35
  • 74.07 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9739 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.14669 34
zebrafish
(Danio rerio)
Actinopterygii selk 34 35
  • 63.3 (n)
Species where no ortholog for SELENOK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SELENOK Gene

ENSEMBL:
Gene Tree for SELENOK (if available)
TreeFam:
Gene Tree for SELENOK (if available)

Paralogs for SELENOK Gene

Pseudogenes.org Pseudogenes for SELENOK Gene

genes like me logo Genes that share paralogs with SELENOK: view

No data available for Paralogs for SELENOK Gene

Variants for SELENOK Gene

Sequence variations from dbSNP and Humsavar for SELENOK Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1020082 -- 53,886,995(-) CATGG(A/G)AATAT intron-variant
rs10440151 -- 53,887,001(+) CCATG(G/T)TTTTT intron-variant
rs11130383 -- 53,889,718(+) AAAGA(A/T)TGCGT intron-variant
rs11130384 -- 53,889,753(+) AATCA(A/G)TTATT intron-variant
rs112061038 -- 53,891,793(+) TCTTG(A/T)CCCAC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SELENOK Gene

Variant ID Type Subtype PubMed ID
dgv4747n100 CNV gain 25217958
nsv1003621 CNV loss 25217958
nsv1006990 CNV gain 25217958
nsv1013783 CNV gain 25217958
nsv1014752 CNV loss 25217958

Variation tolerance for SELENOK Gene

Gene Damage Index Score: 1.78; 33.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELENOK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELENOK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELENOK Gene

Disorders for SELENOK Gene

Relevant External Links for SELENOK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENOK

No disorders were found for SELENOK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SELENOK Gene

Publications for SELENOK Gene

  1. Identification and characterization of selenoprotein K: an antioxidant in cardiomyocytes. (PMID: 16962588) Lu C. … Peng X. (FEBS Lett. 2006) 3 22 64
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 64
  3. Deducing the functional characteristics of the human selenoprotein SELK from the structural properties of its intrinsically disordered C-terminal domain. (PMID: 26735936) Polo A. … Costantini S. (Mol Biosyst 2016) 3 64
  4. Overexpression of Selenoprotein SelK in BGC-823 Cells Inhibits Cell Adhesion and Migration. (PMID: 26567579) Ben S.B. … Chen C.L. (Biochemistry Mosc. 2015) 3 64
  5. Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex. (PMID: 25368151) Fredericks G.J. … Hoffmann P.R. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 64

Products for SELENOK Gene

Sources for SELENOK Gene

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