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Aliases for SELENOK Gene

Aliases for SELENOK Gene

  • Selenoprotein K 2 3 5
  • SELK 3 4
  • HSPC030 3
  • HSPC297 3

External Ids for SELENOK Gene

Summaries for SELENOK Gene

Entrez Gene Summary for SELENOK Gene

  • The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced apoptosis. Knockout studies in mice show the importance of this gene in promoting Ca(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Pseudogenes of this locus have been identified on chromosomes 6 and 19.[provided by RefSeq, Aug 2017]

GeneCards Summary for SELENOK Gene

SELENOK (Selenoprotein K) is a Protein Coding gene. Among its related pathways are Selenium Micronutrient Network and Selenium Metabolism and Selenoproteins.

UniProtKB/Swiss-Prot for SELENOK Gene

  • Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration. Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins. Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation. Plays a role in protection of cells from ER stress-induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes.

Additional gene information for SELENOK Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELENOK Gene

Genomics for SELENOK Gene

Regulatory Elements for SELENOK Gene

Enhancers for SELENOK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H053890 1.1 ENCODE 6.6 +0.2 169 2 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 ACTR8 RFT1 SELENOK ENSG00000271976
GH03H053747 1.3 FANTOM5 Ensembl ENCODE 2.9 +142.6 142588 2 BACH1 EBF1 RELA ETS1 EED ATF7 ETV6 IKZF2 SMARCA5 MAZ IL17RB SELENOK DCP1A GC03P053782 PIR47826
GH03H054026 0.2 ENCODE 0.1 -134.8 -134803 0 LOC105377095 SELENOK
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SELENOK on UCSC Golden Path with GeneCards custom track

Promoters for SELENOK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000152708 188 2000 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207

Genomic Location for SELENOK Gene

Chromosome:
3
Start:
53,884,410 bp from pter
End:
53,891,988 bp from pter
Size:
7,579 bases
Orientation:
Minus strand

Genomic View for SELENOK Gene

Genes around SELENOK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELENOK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELENOK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELENOK Gene

Proteins for SELENOK Gene

  • Protein details for SELENOK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6D0-SELK_HUMAN
    Recommended name:
    Selenoprotein K
    Protein Accession:
    Q9Y6D0
    Secondary Accessions:
    • Q8IZQ3
    • Q9P085

    Protein attributes for SELENOK Gene

    Size:
    94 amino acids
    Molecular mass:
    10645 Da
    Quaternary structure:
    • Interacts with DERL1, DERL2, DERL3 and SELENOS. The SELENOK-SELENOS complex interacts with VCP.
    SequenceCaution:
    • Sequence=AAD40194.1; Type=Erroneous termination; Positions=92; Note=Translated as Sec.; Evidence={ECO:0000305}; Sequence=AAF28975.1; Type=Erroneous termination; Positions=92; Note=Translated as Sec.; Evidence={ECO:0000305};

neXtProt entry for SELENOK Gene

Post-translational modifications for SELENOK Gene

  • Cleaved by CAPN2/m-calpain in resting macrophages but not in activated macrophages. Macrophage activation up-regulates expression of the calpain inhibitor CAST/calpastatin, resulting in inhibition of CAPN2 activity (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SELENOK Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SELENOK Gene

Domains & Families for SELENOK Gene

Gene Families for SELENOK Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SELENOK Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SELENOK Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6D0

UniProtKB/Swiss-Prot:

SELK_HUMAN :
  • Belongs to the selenoprotein K family.
Family:
  • Belongs to the selenoprotein K family.
genes like me logo Genes that share domains with SELENOK: view

Function for SELENOK Gene

Molecular function for SELENOK Gene

UniProtKB/Swiss-Prot Function:
Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration. Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins. Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation. Plays a role in protection of cells from ER stress-induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes.
UniProtKB/Swiss-Prot Induction:
By ER stress (at protein level). Displays a slow increase with a lag phase of 6 hours but exhibits a dramatic increase after incubation with ER stress agents for more than 12 hours with maximum induction at 24 hours. Also induced by accumulation of misfolded proteins in the ER.

Gene Ontology (GO) - Molecular Function for SELENOK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IPI 25117454
genes like me logo Genes that share ontologies with SELENOK: view
genes like me logo Genes that share phenotypes with SELENOK: view

Animal Models for SELENOK Gene

MGI Knock Outs for SELENOK:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SELENOK
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SELENOK Gene

Localization for SELENOK Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELENOK Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein. Note=Probably mainly localized in the ER. {ECO:0000269 PubMed:21220695}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELENOK gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
golgi apparatus 3
extracellular 2
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SELENOK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA 16962588
GO:0005789 endoplasmic reticulum membrane IDA 21220695
GO:0005794 Golgi apparatus IBA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SELENOK: view

Pathways & Interactions for SELENOK Gene

genes like me logo Genes that share pathways with SELENOK: view

Pathways by source for SELENOK Gene

Interacting Proteins for SELENOK Gene

Gene Ontology (GO) - Biological Process for SELENOK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IEA --
GO:0002376 immune system process IBA --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006816 calcium ion transport IBA --
genes like me logo Genes that share ontologies with SELENOK: view

No data available for SIGNOR curated interactions for SELENOK Gene

Drugs & Compounds for SELENOK Gene

(2) Drugs for SELENOK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenium Approved, Vet_approved Pharma 185
Selenocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with SELENOK: view

Transcripts for SELENOK Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SELENOK
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SELENOK Gene

No ASD Table

Relevant External Links for SELENOK Gene

GeneLoc Exon Structure for
SELENOK
ECgene alternative splicing isoforms for
SELENOK

Expression for SELENOK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA Expression by UniProt/SwissProt for SELENOK Gene:

Q9Y6D0-SELK_HUMAN
Tissue specificity: Highly expressed in heart.

Evidence on tissue expression from TISSUES for SELENOK Gene

  • Blood(4.6)
  • Adrenal gland(4.3)
  • Nervous system(3.7)
  • Pancreas(2.9)
  • Eye(2.3)
  • Muscle(2.2)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with SELENOK: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SELENOK Gene

Orthologs for SELENOK Gene

This gene was present in the common ancestor of chordates.

Orthologs for SELENOK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SELK 33 34
  • 98.94 (n)
dog
(Canis familiaris)
Mammalia SELK 33
  • 95.04 (n)
cow
(Bos Taurus)
Mammalia SELK 33 34
  • 92.91 (n)
rat
(Rattus norvegicus)
Mammalia Selk 33
  • 89.36 (n)
mouse
(Mus musculus)
Mammalia Selk 33 34
  • 89.01 (n)
Selenok 16
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves SELK 33 34
  • 74.07 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14669 33
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9739 33
zebrafish
(Danio rerio)
Actinopterygii selk 33 34
  • 63.3 (n)
Species where no ortholog for SELENOK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SELENOK Gene

ENSEMBL:
Gene Tree for SELENOK (if available)
TreeFam:
Gene Tree for SELENOK (if available)

Paralogs for SELENOK Gene

Pseudogenes.org Pseudogenes for SELENOK Gene

genes like me logo Genes that share paralogs with SELENOK: view

No data available for Paralogs for SELENOK Gene

Variants for SELENOK Gene

Sequence variations from dbSNP and Humsavar for SELENOK Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1001312325 -- 53,887,322(+) GCACA(A/G)GGCTT intron-variant
rs1001411475 -- 53,886,745(+) AAATA(A/G)GATTT intron-variant
rs1002285068 -- 53,892,658(+) TTCCC(A/G/T)CCCCC upstream-variant-2KB
rs1002439078 -- 53,891,525(+) GAAGG(C/T)GGGGT intron-variant
rs1003695311 -- 53,891,679(+) CGCAC(C/G)GGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SELENOK Gene

Variant ID Type Subtype PubMed ID
dgv4747n100 CNV gain 25217958
nsv1003621 CNV loss 25217958
nsv1006990 CNV gain 25217958
nsv1013783 CNV gain 25217958
nsv1014752 CNV loss 25217958

Variation tolerance for SELENOK Gene

Gene Damage Index Score: 1.78; 33.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELENOK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELENOK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELENOK Gene

Disorders for SELENOK Gene

Relevant External Links for SELENOK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENOK

No disorders were found for SELENOK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SELENOK Gene

Publications for SELENOK Gene

  1. Identification and characterization of selenoprotein K: an antioxidant in cardiomyocytes. (PMID: 16962588) Lu C … Peng X (FEBS letters 2006) 3 4 22 60
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 60
  3. Selenoprotein K binds multiprotein complexes and is involved in the regulation of endoplasmic reticulum homeostasis. (PMID: 22016385) Shchedrina VA … Gladyshev VN (The Journal of biological chemistry 2011) 3 4 60
  4. Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses. (PMID: 21220695) Verma S … Hoffmann PR (Journal of immunology (Baltimore, Md. : 1950) 2011) 3 4 60
  5. SelK is a novel ER stress-regulated protein and protects HepG2 cells from ER stress agent-induced apoptosis. (PMID: 20692228) Du S … Huang K (Archives of biochemistry and biophysics 2010) 3 4 60

Products for SELENOK Gene

Sources for SELENOK Gene

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