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Aliases for SELENOH Gene

Aliases for SELENOH Gene

  • Selenoprotein H 2 3 5
  • C11orf31 3 4
  • SELH 3 4
  • Chromosome 11 Open Reading Frame 31 2
  • C17orf10 3

External Ids for SELENOH Gene

Previous HGNC Symbols for SELENOH Gene

  • C11orf31

Summaries for SELENOH Gene

Entrez Gene Summary for SELENOH Gene

  • This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016]

GeneCards Summary for SELENOH Gene

SELENOH (Selenoprotein H) is a Protein Coding gene. Among its related pathways are Folate Metabolism and Selenium Metabolism and Selenoproteins.

UniProtKB/Swiss-Prot for SELENOH Gene

  • May be involved in a redox-related process.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELENOH Gene

Genomics for SELENOH Gene

Regulatory Elements for SELENOH Gene

Enhancers for SELENOH Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F057773 1.6 FANTOM5 Ensembl ENCODE 13.6 +40.6 40620 16.1 PKNOX1 MLX WRNIP1 SIN3A FEZF1 FOS KLF13 SP5 NFYC ZHX2 YPEL4 TIMM10 MED19 SELENOH BTBD18 CTNND1 ENSG00000254732 CLP1 ENSG00000254602 SMTNL1
GH11F057760 0.4 ENCODE 11.9 +22.2 22210 5.3 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 SSRP1 TNKS1BP1 MED19 YPEL4 SELENOH ENSG00000254732 ENSG00000269570 CTNND1 ZDHHC5 UBE2L6
GH11F057770 0.4 Ensembl 11.9 +29.6 29551 0.8 YY1 ENSG00000254732 SELENOH YPEL4 CLP1 ENSG00000254602 BTBD18 PIR53177
GH11F057772 1.2 Ensembl ENCODE 11.9 +31.6 31551 1.6 PKNOX1 ZNF384 FEZF1 HIC1 ZFHX2 ZNF366 GLIS1 PBX2 PRDM1 SP7 YPEL4 MED19 SELENOH ENSG00000254732 CLP1 ENSG00000254602 BTBD18 PIR53177
GH11F057797 1.2 Ensembl ENCODE 11.9 +59.4 59387 5.6 HDGF PKNOX1 MLX ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF143 FOS MED19 YPEL4 SSRP1 BTBD18 CTNND1 SELENOH ENSG00000254732 ENSG00000269570 ZDHHC5 TIMM10
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SELENOH on UCSC Golden Path with GeneCards custom track

Promoters for SELENOH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001570406 450 1801 HDGF PKNOX1 ARNT MLX CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1

Genomic Location for SELENOH Gene

Chromosome:
11
Start:
57,741,250 bp from pter
End:
57,743,554 bp from pter
Size:
2,305 bases
Orientation:
Plus strand

Genomic View for SELENOH Gene

Genes around SELENOH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELENOH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELENOH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELENOH Gene

Proteins for SELENOH Gene

  • Protein details for SELENOH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZQ5-SELH_HUMAN
    Recommended name:
    Selenoprotein H
    Protein Accession:
    Q8IZQ5
    Secondary Accessions:
    • Q8N672

    Protein attributes for SELENOH Gene

    Size:
    122 amino acids
    Molecular mass:
    13453 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SELENOH Gene

Post-translational modifications for SELENOH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SELENOH Gene

No data available for DME Specific Peptides for SELENOH Gene

Domains & Families for SELENOH Gene

Gene Families for SELENOH Gene

Protein Domains for SELENOH Gene

Suggested Antigen Peptide Sequences for SELENOH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZQ5

UniProtKB/Swiss-Prot:

SELH_HUMAN :
  • Belongs to the SelWTH family.
Family:
  • Belongs to the SelWTH family.
genes like me logo Genes that share domains with SELENOH: view

Function for SELENOH Gene

Molecular function for SELENOH Gene

UniProtKB/Swiss-Prot Function:
May be involved in a redox-related process.

Gene Ontology (GO) - Molecular Function for SELENOH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with SELENOH: view
genes like me logo Genes that share phenotypes with SELENOH: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SELENOH Gene

Localization for SELENOH Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SELENOH Gene

Pathways & Interactions for SELENOH Gene

genes like me logo Genes that share pathways with SELENOH: view

Pathways by source for SELENOH Gene

2 BioSystems pathways for SELENOH Gene

Interacting Proteins for SELENOH Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000373509%0d%0a9606.ENSP00000425845%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q8IZQ5-SELH_HUMAN ENSP00000373509 for SELENOH Gene via IID STRING

Gene Ontology (GO) - Biological Process for SELENOH Gene

None

No data available for SIGNOR curated interactions for SELENOH Gene

Transcripts for SELENOH Gene

Unigene Clusters for SELENOH Gene

Chromosome 11 open reading frame 31:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELENOH Gene

No ASD Table

Relevant External Links for SELENOH Gene

GeneLoc Exon Structure for
SELENOH
ECgene alternative splicing isoforms for
SELENOH

Expression for SELENOH Gene

NURSA nuclear receptor signaling pathways regulating expression of SELENOH Gene:

SELENOH

SOURCE GeneReport for Unigene cluster for SELENOH Gene:

Hs.655373
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SELENOH Gene

Orthologs for SELENOH Gene

This gene was present in the common ancestor of chordates.

Orthologs for SELENOH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C11H11orf31 34 35
  • 99.73 (n)
dog
(Canis familiaris)
Mammalia C18H11orf31 34
  • 88.25 (n)
cow
(Bos Taurus)
Mammalia C15H11orf31 34
  • 84.7 (n)
mouse
(Mus musculus)
Mammalia 2700094K13Rik 34 16 35
  • 81.32 (n)
rat
(Rattus norvegicus)
Mammalia RGD1563348 34
  • 80.46 (n)
chicken
(Gallus gallus)
Aves LOC100858006 34
  • 65.57 (n)
lizard
(Anolis carolinensis)
Reptilia C11orf31 35
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii seph 34
  • 64.37 (n)
Species where no ortholog for SELENOH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SELENOH Gene

ENSEMBL:
Gene Tree for SELENOH (if available)
TreeFam:
Gene Tree for SELENOH (if available)

Paralogs for SELENOH Gene

No data available for Paralogs for SELENOH Gene

Variants for SELENOH Gene

Sequence variations from dbSNP and Humsavar for SELENOH Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1058118 -- 57,740,910(+) ACCCT(C/T)TGACA intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs111835331 -- 57,742,712(+) TGTTC(-/T)GCACT intron-variant
rs112095568 -- 57,740,968(+) TTTCC(C/T)TTTGA intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs11229113 -- 57,743,351(+) GCGGG(G/T)TTTCA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1127680 -- 57,741,941(+) CTGCG(C/T)CCGGA intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SELENOH Gene

Variant ID Type Subtype PubMed ID
nsv326 CNV insertion 18451855
nsv508633 CNV deletion 20534489
nsv832164 CNV loss 17160897

Variation tolerance for SELENOH Gene

Residual Variation Intolerance Score: 49.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELENOH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELENOH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELENOH Gene

Disorders for SELENOH Gene

Relevant External Links for SELENOH

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENOH
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENOH

No disorders were found for SELENOH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SELENOH Gene

Publications for SELENOH Gene

  1. Characterization of mammalian selenoproteomes. (PMID: 12775843) Kryukov G.V. … Gladyshev V.N. (Science 2003) 2 3 4 64
  2. Overexpression of human selenoprotein H in neuronal cells ameliorates ultraviolet irradiation-induced damage by modulating cell signaling pathways. (PMID: 19766117) Mendelev N. … Li P.A. (Exp. Neurol. 2009) 3 22 64
  3. Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern. (PMID: 17337453) Novoselov S.V. … Gladyshev V.N. (J. Biol. Chem. 2007) 3 22 64
  4. Overexpression of selenoprotein H reduces Ht22 neuronal cell death after UVB irradiation by preventing superoxide formation. (PMID: 17389926) Ben Jilani K.E. … Li P.A. (Int. J. Biol. Sci. 2007) 3 22 64
  5. Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification. (PMID: 17526492) Panee J. … Berry M.J. (J. Biol. Chem. 2007) 3 22 64

Products for SELENOH Gene

Sources for SELENOH Gene

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