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Aliases for SELENOF Gene

Aliases for SELENOF Gene

  • Selenoprotein F 2 3 5
  • Selenoprotein F (15kDa) 2
  • 15 KDa Selenoprotein 3
  • SEP15 3

External Ids for SELENOF Gene

Summaries for SELENOF Gene

Entrez Gene Summary for SELENOF Gene

  • The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. It has also been suggested to have a role in cancer etiology. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2016]

GeneCards Summary for SELENOF Gene

SELENOF (Selenoprotein F) is a Protein Coding gene. Among its related pathways are Folate Metabolism.

Gene Wiki entry for SELENOF Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELENOF Gene

Genomics for SELENOF Gene

Regulatory Elements for SELENOF Gene

Enhancers for SELENOF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F087115 0.4 ENCODE 5.6 -201.3 -201284 1.0 ZNF341 PRDM10 LOC105378828 SELENOF LINC01140 GC01P087094
GH01F086912 1.1 ENCODE 0.8 -0.2 -221 4.4 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ENSG00000267734 LOC100420166 LOC105378828 HS2ST1 SELENOF
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SELENOF on UCSC Golden Path with GeneCards custom track

Genomic Location for SELENOF Gene

Chromosome:
1
Start:
86,862,445 bp from pter
End:
86,914,424 bp from pter
Size:
51,980 bases
Orientation:
Minus strand

Genomic View for SELENOF Gene

Genes around SELENOF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELENOF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELENOF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELENOF Gene

Proteins for SELENOF Gene

  • Protein details for SELENOF Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A087WXL0
    Recommended name:
    15 kDa selenoprotein
    Protein Accession:
    A0A087WXL0

    Protein attributes for SELENOF Gene

    Size:
    123 amino acids
    Molecular mass:
    13371 Da
    Quaternary structure:
    No Data Available
  • Protein details for SELENOF Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A087X1G7
    Recommended name:
    15 kDa selenoprotein
    Protein Accession:
    A0A087X1G7

    Protein attributes for SELENOF Gene

    Size:
    164 amino acids
    Molecular mass:
    17942 Da
    Quaternary structure:
    No Data Available
  • Protein details for SELENOF Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0B4J1S4
    Recommended name:
    15 kDa selenoprotein
    Protein Accession:
    A0A0B4J1S4

    Protein attributes for SELENOF Gene

    Size:
    165 amino acids
    Molecular mass:
    18045 Da
    Quaternary structure:
    No Data Available
  • Protein details for SELENOF Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0B4J1T0
    Recommended name:
    15 kDa selenoprotein
    Protein Accession:
    A0A0B4J1T0

    Protein attributes for SELENOF Gene

    Size:
    124 amino acids
    Molecular mass:
    13474 Da
    Quaternary structure:
    No Data Available
  • Protein details for SELENOF Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0J9YX89
    Recommended name:
    15 kDa selenoprotein
    Protein Accession:
    A0A0J9YX89

    Protein attributes for SELENOF Gene

    Size:
    88 amino acids
    Molecular mass:
    10186 Da
    Quaternary structure:
    No Data Available
  • Protein details for SELENOF Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0J9YXM9
    Recommended name:
    15 kDa selenoprotein
    Protein Accession:
    A0A0J9YXM9

    Protein attributes for SELENOF Gene

    Size:
    31 amino acids
    Molecular mass:
    3434 Da
    Quaternary structure:
    No Data Available
  • Protein details for SELENOF Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A8MZD0
    Recommended name:
    15 kDa selenoprotein
    Protein Accession:
    A8MZD0

    Protein attributes for SELENOF Gene

    Size:
    144 amino acids
    Molecular mass:
    15691 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SELENOF Gene

Post-translational modifications for SELENOF Gene

No Post-translational modifications

Other Protein References for SELENOF Gene

No data available for DME Specific Peptides for SELENOF Gene

Domains & Families for SELENOF Gene

Gene Families for SELENOF Gene

Protein Domains for SELENOF Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SELENOF: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SELENOF Gene

Function for SELENOF Gene

Gene Ontology (GO) - Molecular Function for SELENOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008430 selenium binding IDA 9535873
genes like me logo Genes that share ontologies with SELENOF: view
genes like me logo Genes that share phenotypes with SELENOF: view

Animal Models for SELENOF Gene

MGI Knock Outs for SELENOF:

Animal Model Products

miRNA for SELENOF Gene

miRTarBase miRNAs that target SELENOF

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SELENOF Gene

Localization for SELENOF Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELENOF gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for SELENOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen IDA 11278576
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SELENOF: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SELENOF Gene

Pathways & Interactions for SELENOF Gene

SuperPathways for SELENOF Gene

SuperPathway Contained pathways
1 Folate Metabolism
genes like me logo Genes that share pathways with SELENOF: view

Pathways by source for SELENOF Gene

1 BioSystems pathway for SELENOF Gene

Interacting Proteins for SELENOF Gene

Gene Ontology (GO) - Biological Process for SELENOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051084 de novo posttranslational protein folding TAS 11278576
genes like me logo Genes that share ontologies with SELENOF: view

No data available for SIGNOR curated interactions for SELENOF Gene

Drugs & Compounds for SELENOF Gene

(2) Drugs for SELENOF Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenocysteine Experimental Pharma 0
Selenium Pharma 175
genes like me logo Genes that share compounds with SELENOF: view

Transcripts for SELENOF Gene

Unigene Clusters for SELENOF Gene

15 kDa selenoprotein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELENOF Gene

No ASD Table

Relevant External Links for SELENOF Gene

GeneLoc Exon Structure for
SELENOF
ECgene alternative splicing isoforms for
SELENOF

Expression for SELENOF Gene

SOURCE GeneReport for Unigene cluster for SELENOF Gene:

Hs.362728
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SELENOF Gene

Orthologs for SELENOF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SELENOF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEP15 34 35
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia SEP15 34
  • 89.71 (n)
cow
(Bos Taurus)
Mammalia SEP15 34
  • 88.48 (n)
mouse
(Mus musculus)
Mammalia Sep15 34 16 35
  • 87.65 (n)
rat
(Rattus norvegicus)
Mammalia Sep15 34
  • 86.63 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEP15 34 35
  • 79.29 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 82 (a)
OneToMany
-- 35
  • 71 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia sep15 34
  • 76.03 (n)
zebrafish
(Danio rerio)
Actinopterygii sep15 34 35
  • 76.03 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10708 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004986 34
  • 52.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7484 34 35
  • 49.06 (n)
worm
(Caenorhabditis elegans)
Secernentea Y76B12C.3 34 35
  • 52.68 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G05720 34
  • 45.06 (n)
rice
(Oryza sativa)
Liliopsida Os01g0894500 34
  • 47.79 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4882 34
Species where no ortholog for SELENOF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SELENOF Gene

ENSEMBL:
Gene Tree for SELENOF (if available)
TreeFam:
Gene Tree for SELENOF (if available)

Paralogs for SELENOF Gene

Pseudogenes.org Pseudogenes for SELENOF Gene

genes like me logo Genes that share paralogs with SELENOF: view

No data available for Paralogs for SELENOF Gene

Variants for SELENOF Gene

Sequence variations from dbSNP and Humsavar for SELENOF Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs101028 -- 86,914,313(+) CACTT(G/T)CCTAA upstream-variant-2KB, utr-variant-5-prime
rs10563057 -- 86,902,835(+) TAAAC(-/TAAC)AGTCC intron-variant
rs10633486 -- 86,886,433(+) AGTAC(-/TT)TTTTT intron-variant
rs10714134 -- 86,893,469(+) AAAAA(-/A)TAGCC intron-variant
rs10717903 -- 86,897,004(+) CATTT(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SELENOF Gene

Variant ID Type Subtype PubMed ID
nsv473936 CNV novel sequence insertion 20440878
nsv1777 CNV insertion 18451855
esv3582137 CNV gain 25503493
esv1340746 CNV insertion 17803354

Relevant External Links for SELENOF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELENOF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SELENOF Gene

Disorders for SELENOF Gene

Relevant External Links for SELENOF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENOF

No disorders were found for SELENOF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SELENOF Gene

Publications for SELENOF Gene

  1. Genetic variants in selenoprotein genes increase risk of colorectal cancer. (PMID: 20378690) MAcplan C. … Hesketh J.E. (Carcinogenesis 2010) 3 22 64
  2. Lung cancer risk associated with selenium status is modified in smoking individuals by Sep15 polymorphism. (PMID: 18239845) Jablonska E. … Wasowicz W. (Eur J Nutr 2008) 3 22 64
  3. Growth inhibition and induction of apoptosis in mesothelioma cells by selenium and dependence on selenoprotein SEP15 genotype. (PMID: 15107826) Apostolou S. … Testa J.R. (Oncogene 2004) 3 22 64
  4. Structure-expression relationships of the 15-kDa selenoprotein gene. Possible role of the protein in cancer etiology. (PMID: 10945981) Kumaraswamy E. … Gladyshev V.N. (J. Biol. Chem. 2000) 2 3 64
  5. A new human selenium-containing protein. Purification, characterization, and cDNA sequence. (PMID: 9535873) Gladyshev V.N. … Hatfield D.L. (J. Biol. Chem. 1998) 2 3 64

Products for SELENOF Gene

Sources for SELENOF Gene

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