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Aliases for SELENOF Gene

Aliases for SELENOF Gene

  • Selenoprotein F 2 3 5
  • 15 KDa Selenoprotein 3 4
  • SEP15 3 4
  • Selenoprotein F (15kDa) 2

External Ids for SELENOF Gene

Summaries for SELENOF Gene

Entrez Gene Summary for SELENOF Gene

  • The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. It has also been suggested to have a role in cancer etiology. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2016]

GeneCards Summary for SELENOF Gene

SELENOF (Selenoprotein F) is a Protein Coding gene. Among its related pathways are Folate Metabolism.

UniProtKB/Swiss-Prot for SELENOF Gene

  • May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum (By similarity).

Gene Wiki entry for SELENOF Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELENOF Gene

Genomics for SELENOF Gene

Regulatory Elements for SELENOF Gene

Enhancers for SELENOF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G087115 0.5 ENCODE 5.6 -201.3 -201284 1.0 NFIC ZNF341 PRDM10 LOC105378828 SELENOF LINC01140 GC01P087094
GH01G086912 1.1 ENCODE 0.7 -0.2 -221 4.4 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 LOC105378828 HS2ST1 SELENOF
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SELENOF on UCSC Golden Path with GeneCards custom track

Promoters for SELENOF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000009364 -276 3801 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A FEZF1

Genomic Location for SELENOF Gene

Chromosome:
1
Start:
86,862,445 bp from pter
End:
86,914,424 bp from pter
Size:
51,980 bases
Orientation:
Minus strand

Genomic View for SELENOF Gene

Genes around SELENOF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELENOF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELENOF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELENOF Gene

Proteins for SELENOF Gene

  • Protein details for SELENOF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60613-SEP15_HUMAN
    Recommended name:
    Selenoprotein F
    Protein Accession:
    O60613
    Secondary Accessions:
    • Q4GZG7
    • Q8WU00
    • Q9BS64
    • Q9GZW0
    • Q9NR01

    Protein attributes for SELENOF Gene

    Size:
    162 amino acids
    Molecular mass:
    17790 Da
    Quaternary structure:
    • Forms a tight complex with UGGT1/UGCGL1.
    SequenceCaution:
    • Sequence=AAH05294.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH16359.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH21697.3; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SELENOF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SELENOF Gene

Post-translational modifications for SELENOF Gene

Other Protein References for SELENOF Gene

No data available for DME Specific Peptides for SELENOF Gene

Domains & Families for SELENOF Gene

Gene Families for SELENOF Gene

Protein Domains for SELENOF Gene

Graphical View of Domain Structure for InterPro Entry

O60613

UniProtKB/Swiss-Prot:

SEP15_HUMAN :
  • Belongs to the selenoprotein M/F family.
Family:
  • Belongs to the selenoprotein M/F family.
genes like me logo Genes that share domains with SELENOF: view

No data available for Suggested Antigen Peptide Sequences for SELENOF Gene

Function for SELENOF Gene

Molecular function for SELENOF Gene

UniProtKB/Swiss-Prot Function:
May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum (By similarity).
genes like me logo Genes that share phenotypes with SELENOF: view

Animal Models for SELENOF Gene

MGI Knock Outs for SELENOF:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SELENOF Gene

Localization for SELENOF Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELENOF Gene

Endoplasmic reticulum lumen. Note=The association with UGGT1/UGCGL1 is essential for its retention in the endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELENOF gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for SELENOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen IDA 11278576
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SELENOF: view

Pathways & Interactions for SELENOF Gene

SuperPathways for SELENOF Gene

SuperPathway Contained pathways
1 Folate Metabolism
genes like me logo Genes that share pathways with SELENOF: view

Pathways by source for SELENOF Gene

1 BioSystems pathway for SELENOF Gene

Gene Ontology (GO) - Biological Process for SELENOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051084 de novo posttranslational protein folding TAS 11278576
genes like me logo Genes that share ontologies with SELENOF: view

No data available for SIGNOR curated interactions for SELENOF Gene

Drugs & Compounds for SELENOF Gene

(2) Drugs for SELENOF Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenium Approved, Vet_approved Pharma 180
Selenocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with SELENOF: view

Transcripts for SELENOF Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELENOF Gene

No ASD Table

Relevant External Links for SELENOF Gene

GeneLoc Exon Structure for
SELENOF
ECgene alternative splicing isoforms for
SELENOF

Expression for SELENOF Gene

mRNA Expression by UniProt/SwissProt for SELENOF Gene:

O60613-SEP15_HUMAN
Tissue specificity: Higher levels in prostate and thyroid gland.

Evidence on tissue expression from TISSUES for SELENOF Gene

  • Kidney(4.6)
  • Nervous system(4.6)
  • Bone marrow(4.3)
  • Lung(3.5)
  • Intestine(2.9)
  • Pancreas(2.9)
  • Liver(2.8)
  • Thyroid gland(2.8)
  • Adrenal gland(2.1)
  • Blood(2.1)
  • Gall bladder(2)
  • Lymph node(2)
  • Stomach(2)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SELENOF Gene

Orthologs for SELENOF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SELENOF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEP15 34 35
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia SEP15 34
  • 89.71 (n)
cow
(Bos Taurus)
Mammalia SEP15 34
  • 88.48 (n)
mouse
(Mus musculus)
Mammalia Sep15 34 35
  • 87.65 (n)
Selenof 16
rat
(Rattus norvegicus)
Mammalia Sep15 34
  • 86.63 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEP15 34 35
  • 79.29 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 82 (a)
OneToMany
-- 35
  • 71 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia sep15 34
  • 76.03 (n)
zebrafish
(Danio rerio)
Actinopterygii sep15 34 35
  • 76.03 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10708 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004986 34
  • 52.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7484 34 35
  • 49.06 (n)
worm
(Caenorhabditis elegans)
Secernentea Y76B12C.3 34 35
  • 52.68 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G05720 34
  • 45.06 (n)
rice
(Oryza sativa)
Liliopsida Os01g0894500 34
  • 47.79 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4882 34
Species where no ortholog for SELENOF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SELENOF Gene

ENSEMBL:
Gene Tree for SELENOF (if available)
TreeFam:
Gene Tree for SELENOF (if available)

Paralogs for SELENOF Gene

Pseudogenes.org Pseudogenes for SELENOF Gene

genes like me logo Genes that share paralogs with SELENOF: view

No data available for Paralogs for SELENOF Gene

Variants for SELENOF Gene

Sequence variations from dbSNP and Humsavar for SELENOF Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000006305 -- 86,864,287(+) ATTAG(C/T)TGGGT intron-variant
rs1000037087 -- 86,878,201(+) GGTTT(A/C)ATATA intron-variant
rs1000067556 -- 86,876,185(+) AAGAG(A/G)AAGGG intron-variant
rs1000098268 -- 86,875,910(+) GAGAG(C/T)TGCAC intron-variant
rs1000229873 -- 86,893,965(+) AAGAT(A/G)AGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SELENOF Gene

Variant ID Type Subtype PubMed ID
esv1340746 CNV insertion 17803354
esv3582137 CNV gain 25503493
nsv1777 CNV insertion 18451855
nsv473936 CNV novel sequence insertion 20440878

Relevant External Links for SELENOF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELENOF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SELENOF Gene

Disorders for SELENOF Gene

Relevant External Links for SELENOF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENOF

No disorders were found for SELENOF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SELENOF Gene

Publications for SELENOF Gene

  1. Structure-expression relationships of the 15-kDa selenoprotein gene. Possible role of the protein in cancer etiology. (PMID: 10945981) Kumaraswamy E. … Gladyshev V.N. (J. Biol. Chem. 2000) 2 3 4 64
  2. A new human selenium-containing protein. Purification, characterization, and cDNA sequence. (PMID: 9535873) Gladyshev V.N. … Hatfield D.L. (J. Biol. Chem. 1998) 2 3 4 64
  3. Genetic variants in selenoprotein genes increase risk of colorectal cancer. (PMID: 20378690) MAcplan C. … Hesketh J.E. (Carcinogenesis 2010) 3 22 64
  4. Lung cancer risk associated with selenium status is modified in smoking individuals by Sep15 polymorphism. (PMID: 18239845) Jablonska E. … Wasowicz W. (Eur J Nutr 2008) 3 22 64
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64

Products for SELENOF Gene

Sources for SELENOF Gene

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