Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SELENBP1 Gene

protein-coding   GIFtS: 61
GCID: GC01M151339

Selenium Binding Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Selenium Binding Protein 11 2     LPSB2
SP562 3 5     hSBP2
56 KDa Selenium-Binding Protein2 3     Selenium-Binding Protein 12
SBP562 3     SBP3

External Ids:    HGNC: 107191   Entrez Gene: 89912   Ensembl: ENSG000001434167   OMIM: 6041885   UniProtKB: Q132283   

Export aliases for SELENBP1 gene to outside databases

Previous GC identifers: GC01M149178 GC01M147084 GC01M148111 GC01M148554 GC01M148555 GC01M148149 GC01M149603 GC01M122714


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SELENBP1 Gene:
This gene encodes a member of the selenium-binding protein family. Selenium is an essential nutrient that exhibits
potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. The effects
of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins, and
decreased expression of this gene may be associated with several types of cancer. The encoded protein may play a
selenium-dependent role in ubiquitination/deubiquitination-mediated protein degradation. Alternatively spliced
transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Apr 2012)

GeneCards Summary for SELENBP1 Gene: 
SELENBP1 (selenium binding protein 1) is a protein-coding gene. Diseases associated with SELENBP1 include neurologic diseases, and psychotic disorder. GO annotations related to this gene include protein binding and selenium binding.

UniProtKB/Swiss-Prot: SBP1_HUMAN, Q13228
Function: Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm.
May be involved in intra-Golgi protein transport (By similarity)

Gene Wiki entry for SELENBP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SELENBP1 gene promoter:
         COUP-TF1   CREB   COUP-TF   deltaCREB   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSELENBP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SELENBP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SELENBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.3

SELENBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SELENBP1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M151339:  view genomic region     (about GC identifiers)

Start:
151,336,778 bp from pter      End:
151,345,209 bp from pter
Size:
8,432 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SBP1_HUMAN, Q13228 (See protein sequence)
Recommended Name: Selenium-binding protein 1  
Size: 472 amino acids; 52391 Da
Subunit: Interacts with USP33
Subcellular location: Nucleus. Cytoplasm, cytosol. Membrane; Peripheral membrane protein (By similarity). Note=May
associate with Golgi membrane. May associate with the membrane of autophagosomes (By similarity)
Sequence caution: Sequence=BAG59258.1; Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: A6NML9 B2RDR3 B4DKP6 B4E1F3 Q49AQ8 Q96GX7
Alternative splicing: 3 isoforms:  Q13228-1   Q13228-2   Q13228-3   

Explore the universe of human proteins at neXtProt for SELENBP1: NX_Q13228

Explore proteomics data for SELENBP1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated (Probable)
  • UniProtKB: The N-terminus is blocked (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13228

  • SELENBP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SELENBP1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001245217.1  NP_001245218.1  NP_003935.2  

    ENSEMBL proteins: 
     ENSP00000357861   ENSP00000413960   ENSP00000397261   ENSP00000402531   ENSP00000395637  
     ENSP00000412816   ENSP00000416206   ENSP00000396209   ENSP00000406222   ENSP00000390433  
     ENSP00000400841   ENSP00000408263  

    Human Recombinant Protein Products for SELENBP1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SELENBP1
    OriGene Protein Over-expression Lysate for SELENBP1
    OriGene MassSpec for SELENBP1 
    OriGene Custom Protein Services for SELENBP1
    GenScript Custom Purified and Recombinant Proteins Services for SELENBP1
    Novus Biologicals SELENBP1 Protein
    Novus Biologicals SELENBP1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SELENBP1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--
    GO:0005829cytosol IEA--
    GO:0016020membrane IEA--

    SELENBP1 for ontologies           About GeneDecksing



    SELENBP1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SELENBP1
    OriGene Custom Antibody Services for SELENBP1
    GenScript Custom Superior Antibodies Services for SELENBP1
    Novus Biologicals SELENBP1 Antibodies
    Abcam antibodies for SELENBP1
    Cloud-Clone Corp. Antibodies for SELENBP1 
    Search ThermoFisher Antibodies for SELENBP1
    LSBio Antibodies in human, mouse, rat for SELENBP1 

    Assay Products for SELENBP1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SELENBP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SELENBP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SELENBP1 
    Cloud-Clone Corp. CLIAs for SELENBP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR008826 Se-bd
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q13228

    ProtoNet protein and cluster: Q13228

    1 Blocks protein domain: IPB008826 56kDa selenium binding

    UniProtKB/Swiss-Prot: SBP1_HUMAN, Q13228
    Similarity: Belongs to the selenium-binding protein family


    SELENBP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SBP1_HUMAN, Q13228
    Function: Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm.
    May be involved in intra-Golgi protein transport (By similarity)
    Induction: Down-regulated by androgen in prostate cancer cells

         Genatlas biochemistry entry for SELENBP1:
    selenium binding protein,56kDa,expressed in heart muscle and other tissues

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19118533
    GO:0008430selenium binding IEA--
         
    SELENBP1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SELENBP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SELENBP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SELENBP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SELENBP1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SELENBP1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate SELENBP1:
    hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidSELENBP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SELENBP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SELENBP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SELENBP1
    Sirion Biotech Customized adenovirus for overexpression of SELENBP1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SELENBP1 (see all 8)
    OriGene ORF clones in mouse, rat for SELENBP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SELENBP1 (NM_003944)
    Sino Biological Human cDNA Clone for SELENBP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SELENBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELENBP1
    Sirion Biotech Customized lentivirus for stable overexpression of SELENBP1 
                         Customized lentivirus expression plasmids for stable overexpression of SELENBP1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SELENBP1
    Search LifeMap BioReagents cell lines for SELENBP1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELENBP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SELENBP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Selenium Metabolism and Selenoproteins
    Selenium Metabolism and Selenoproteins


    1 BioSystems Pathway for SELENBP1
        Selenium Metabolism and Selenoproteins



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SELENBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/15 Interacting proteins for SELENBP1 (Q132281, 2, 3 ENSP000003578614) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLDIP2Q9Y2S72, 3MINT-65167 I2D: score=5 
    RPA1P276942, 3MINT-65165 I2D: score=5 
    LRIF1Q5T3J32, 3MINT-65166 I2D: score=4 
    EEDO755302, 3MINT-8270033 I2D: score=2 
    MED31Q9Y3C72, 3, ENSP000002257284MINT-65168 MINT-8270055 I2D: score=5 STRING: ENSP00000225728
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--

    SELENBP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SELENBP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SELENBP1 (SBP1)

    1 HMDB Compound for SELENBP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Seleniumselenium (see all 5)7782-49-2--

    2 Novoseek inferred chemical compound relationships for SELENBP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sp(1-7) 84.9 1 9780359 (1)
    selenium 71.4 47 19896693 (8), 20332323 (4), 16380993 (2), 14991897 (2) (see all 11)

    Search CenterWatch for drugs/clinical trials and news about SELENBP1 / SBP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SELENBP1 gene (3 alternative transcripts): 
    NM_001258288.1  NM_001258289.1  NM_003944.3  

    Unigene Cluster for SELENBP1:

    Selenium binding protein 1
    Hs.632460  [show with all ESTs]
    Unigene Representative Sequence: NM_001258289
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000368868(uc001exx.3 uc010pcz.2) ENST00000493560 ENST00000447402
    ENST00000426705 ENST00000474352(uc001eya.3) ENST00000443708 ENST00000470345
    ENST00000455397 ENST00000427977 ENST00000423070 ENST00000463664 ENST00000424475
    ENST00000458566 ENST00000455839 ENST00000465273 ENST00000473693 ENST00000492643
    ENST00000498494
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SELENBP1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate SELENBP1:
    hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidSELENBP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SELENBP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SELENBP1
    Clone
    Products:
         
    OriGene clones in human, mouse for SELENBP1 (see all 8)
    OriGene ORF clones in mouse, rat for SELENBP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SELENBP1 (NM_003944)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SELENBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELENBP1
    Sirion Biotech Customized lentivirus for stable overexpression of SELENBP1 
                         Customized lentivirus expression plasmids for stable overexpression of SELENBP1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SELENBP1
    OriGene qSTAR qPCR primer pairs in human, mouse for SELENBP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SELENBP1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SELENBP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SELENBP1

    Additional mRNA sequence: 

    AK296661.1 AK298355.1 AK303815.1 AK310044.1 AK315643.1 BC009084.1 CR456852.1 U29091.1 

    24/30 DOTS entries (see all 30):

    DT.456187  DT.100857440  DT.97847992  DT.100857441  DT.97847993  DT.101985014  DT.121350680  DT.100857450 
    DT.121350707  DT.101985013  DT.86857123  DT.92443283  DT.121350704  DT.121350685  DT.92443306  DT.95311371 
    DT.100771340  DT.121350681  DT.121350741  DT.95373468  DT.95373469  DT.95373475  DT.100857439  DT.100857451 

    24/450 AceView cDNA sequences (see all 450):

    AI884468 AW675314 AL529475 BU687598 CR616811 AI672107 BQ773054 BU734476 
    AU124155 CF146347 CR609192 BM694928 BU689556 BM973165 CA394156 BM676720 
    AL602973 AK023875 CR612007 CR625298 CR600884 CF145821 BM696531 CD671787 

    GeneLoc Exon Structure

    5/22 Alternative Splicing Database (ASD) splice patterns (SP) for SELENBP1 (see all 22)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^
    SP1:        -     -     -                       -     -                                   -     -     -                                                         
    SP2:        -     -     -                                                                 -     -     -                                                         
    SP3:        -     -     -                                                                 -     -     -                                                         
    SP4:        -     -     -           -     -     -     -     -     -     -                 -     -     -                       -     -                           
    SP5:        -     -     -                       -     -                                   -     -     -     -     -     -     -     -     -     -               

    ExUns: 12a · 12b ^ 13a · 13b ^ 14
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for SELENBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SELENBP1 expression in normal human tissues (normalized intensities)      SELENBP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCTCTTGGA
    SELENBP1 Expression
    About this image


    SELENBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   
             rectum   
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
             epididymis ; glandular cells   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine ; glandular cells   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             lung ; pneumocytes   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles

    See SELENBP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SELENBP1

    SOURCE GeneReport for Unigene cluster: Hs.632460

    UniProtKB/Swiss-Prot: SBP1_HUMAN, Q13228
    Tissue specificity: Highly expressed in liver, lung, colon, prostate, kidney and pancreas. In brain, present both
    in neurons and glia (at protein level). Down-regulated in lung adenocarcinoma, colorectal carcinoma and ovarian
    cancer. Two-fold up-regulated in brain and blood from schizophrenia patients

        SABiosciences Custom PCR Arrays for SELENBP1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SELENBP1
    OriGene qSTAR qPCR primer pairs in human, mouse for SELENBP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SELENBP1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SELENBP1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SELENBP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELENBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SELENBP1 gene from 9/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Selenbp11 , 5 selenium binding protein 11, 5 86.37(n)1
    87.71(a)1
      3 (40.74 cM)5
    203411  NM_009150.31  NP_033176.21 
     949330565 
    chicken
    (Gallus gallus)
    Aves SELENBP16
    --
    (see all 4)
    --
    75(a)
    75(a)
    (see all 4)
    many → 1
    many → 1
    (see all 4)
    25(1877556-1884725)
    25(2045845-2055226)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 6)
    Uncharacterized protein
    (see all 6)
    62(a)
    59(a)
    (see all 6)
    many → 1
    many → 1
    (see all 6)
    GL343779.1(66135-80351)
    AAWZ02035675(22704-32018)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.48892 Xenopus laevis transcribed sequence with moderate similarity more 80.9(n)    CD360184.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc658442 hypothetical protein MGC65844 77.11(n)   393542  BC056590.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG79663 selenium binding 51(a)   87D10   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y37A1B.53
    CELE_Y37A1B.51
    Protein Y37A1B.51 51(a)
    (best of 2)3
    54.17(n)1
    53.66(a)1
      IV(14051136-14053335)3
    1783601  NM_070290.41  NP_502691.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SBP31 selenium-binding protein 3 58.39(n)
    61.67(a)
      821962  NM_113284.2  NP_189022.1 
    rice
    (Oryza sativa)
    Liliopsida Os.83532 Oryza sativa Os SBP mRNA for putative selenium binding more 73.84(n)    AK071710.1 


    ENSEMBL Gene Tree for SELENBP1 (if available)
    TreeFam Gene Tree for SELENBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/324 SNPs in SELENBP1 are shown (see all 324)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1507998291,2
    --151336469(+) ATTCTC/TTTGAG 3 -- ds50010--------
    rs1394509041,2
    --151336528(+) AAAAAA/CCCAAA 3 -- ds50010--------
    rs1897451951,2
    --151336603(+) TTTCAA/GATTTT 3 -- ds50010--------
    rs1140916911,2
    F--151336635(+) TTGGGC/AATTAT 3 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1808223881,2
    --151336763(+) GGCCCC/TCAAAG 3 -- ds50010--------
    rs1837347051,2
    --151336851(+) GCAACA/GAGCAA 3 -- ut310--------
    rs1163965901,2
    C--151337045(+) ACAATC/TGCCCC 6 N D mis11Minor allele frequency- T:0.01WA 118
    rs2002067351,2
    --151337059(+) GGTAGC/TGGAGC 6 H R mis10--------
    rs2004614851,2
    C--151337060(+) GTAGCA/GGAGCT 6 R C mis10--------
    rs2014607651,2
    --151337100(+) TTCCCA/GAAGTC 6 F syn10--------

    HapMap Linkage Disequilibrium report for SELENBP1 (151336778 - 151345209 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for SELENBP1 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv438026CNV Loss16468122
    nsv831581CNV Loss17160897
    nsv470737CNV Gain18288195
    dgv386n71CNV Gain21882294
    nsv818467CNV Gain17921354
    nsv872427CNV Gain21882294
    nsv824575CNV Gain20364138
    nsv872428CNV Gain21882294
    dgv36n27CNV Gain19166990
    esv34461CNV Gain17911159

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SELENBP1
    DNA2.0 Custom Variant and Variant Library Synthesis for SELENBP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604188    OMIM disorders: --

    20/22 diseases for SELENBP1 (see all 22):    About MalaCards
    neurologic diseases    psychotic disorder    gastric adenocarcinoma    lung adenocarcinoma
    endocarditis    papillary thyroid carcinoma    behcet's disease    uveitis
    leiomyoma    bipolar disorder    adenocarcinoma    thyroiditis
    hypoxia    schizophrenia    gastric cancer    colorectal cancer
    ovarian cancer    hepatocellular carcinoma    esophagitis    prostate cancer

    1 disease from the University of Copenhagen DISEASES database for SELENBP1:
    Hypertension

    SELENBP1 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for SELENBP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 24.2 8 18272210 (2), 19896693 (1), 19924303 (1), 19276359 (1)
    tumors 20.6 39 18272210 (6), 19896693 (5), 19422301 (1), 15378696 (1)
    carcinoma 7.95 12 19896693 (5), 16645984 (2)
    cancer lung 6.64 1 15378762 (1)

    Genetic Association Database (GAD): SELENBP1
    Human Genome Epidemiology (HuGE) Navigator: SELENBP1 (3 documents)

    Export disorders for SELENBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SELENBP1 gene, integrated from 9 sources (see all 61):
    (articles sorted by number of sources associating them with SELENBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, characterization, and chromosomal mapping of a novel cDNA clone encoding human selenium binding protein. (PubMed id 9027582)1, 2, 3 Chang P.W.G.... Fung K. (1997)
    2. Suppression of human selenium-binding protein 1 is a late event in colorectal carcinogenesis and is associated with poor survival. (PubMed id 16645984)1, 2, 9 Kim H.... Kim H. (2006)
    3. Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner. (PubMed id 19118533)1, 2, 9 Jeong J.Y.... Sytkowski A.J. (2009)
    4. Selenium binding protein 1 in ovarian cancer. (PubMed id 16380993)1, 2, 9 Huang K.-C.... Ng S.-W. (2006)
    5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    6. Family-based association study of SELENBP1 in schizop hrenia. (PubMed id 19596560)1, 4 Kanazawa T....Tsuang M.T. (2009)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Progressive loss of selenium-binding protein 1 expres sion correlates with increasing epithelial proliferation and papillary complexi ty in ovarian serous borderline tumor and low-grade serous carcinoma. (PubMed id 19896693)1, 9 Zhang C....Lawrence W.D. (2010)
    9. Decreased selenium-binding protein 1 in esophageal ad enocarcinoma results from posttranscriptional and epigenetic regulation and aff ects chemosensitivity. (PubMed id 20332323)1, 9 Silvers A.L....Chang A.C. (2010)
    10. Transcriptional regulation and biological functions o f selenium-binding protein 1 in colorectal cancer in vitro and in nude mouse xe nografts. (PubMed id 19924303)1, 9 Pohl N.M....Yang W. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8991 HGNC: 10719 AceView: SELENBP1 Ensembl:ENSG00000143416 euGenes: HUgn8991
    ECgene: SELENBP1 H-InvDB: SELENBP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SELENBP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SELENBP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SELENBP1 gene:
    Search GeneIP for patents involving SELENBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SELENBP1   OriGene RNAi products in human, mouse, rat for SELENBP1  
     OriGene qPCR primer pairs and template standards for SELENBP1   OriGene Protein Over-expression Lysate for SELENBP1  
     OriGene MassSpec something-or-other for SELENBP1   OriGene clones in human, mouse for SELENBP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SELENBP1   OriGene Purified Protein for SELENBP1  
     OriGene ORF clones in mouse, rat for SELENBP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SELENBP1   OriGene Custom Protein Services for SELENBP1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SELENBP1
     QIAGEN SeqTarget long-range PCR primers for resequencing SELENBP1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SELENBP1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SELENBP1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SELENBP1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SELENBP1
     GenScript Custom Purified and Recombinant Proteins Services for SELENBP1 GenScript cDNA clones with any tag delivered in your preferred vector for SELENBP1
     GenScript Custom Assay Services for SELENBP1 GenScript Custom Superior Antibodies Services for SELENBP1
     GenScript Custom overexpressing Cell Line Services for SELENBP1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SELENBP1 promoter
     Search Chromatin IP Primers for SELENBP1
     RT2 qPCR Primer Assay in human, mouse, rat SELENBP1
     GNC Network for SELENBP1
     SABiosciences Custom PCR Arrays for SELENBP1
     Search Tocris compounds for SELENBP1 (SBP1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for SELENBP1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SELENBP1 antibodies
     SELENBP1 proteins
     SELENBP1 lysates
     Antibodies for SELENBP1
     See all of Abcam's Antibodies, Kits and Proteins for SELENBP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SELENBP1
     Antibodies for SELENBP1
     ELISAs for SELENBP1
     CLIAs for SELENBP1
     Search LifeMap BioReagents cell lines for SELENBP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELENBP1
     SwitchGear 3'UTR luciferase reporter plasmids for SELENBP1
     SwitchGear Promoter luciferase reporter plasmids for SELENBP1
     Search ThermoFisher Antibodies for SELENBP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELENBP1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SELENBP1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SELENBP1
    Customized:
     lentivirus for stable overexpression of SELENBP1
     lentivirus expression plasmids for stable overexpression of SELENBP1
     adenovirus for overexpression of SELENBP1
     LSBio Antibodies in human, mouse, rat for SELENBP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SELENBP1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4