Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SELENBP1 Gene

Aliases for SELENBP1 Gene

  • Selenium Binding Protein 1 2 3
  • SP56 3 4 6
  • 56 KDa Selenium-Binding Protein 3 4
  • SBP56 3 4
  • Epididymis Secretory Sperm Binding Protein Li 134P 3
  • Selenium-Binding Protein 1 3
  • HEL-S-134P 3
  • LPSB 3
  • HSBP 3
  • SBP 4

External Ids for SELENBP1 Gene

Summaries for SELENBP1 Gene

Entrez Gene Summary for SELENBP1 Gene

  • This gene encodes a member of the selenium-binding protein family. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. The effects of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins, and decreased expression of this gene may be associated with several types of cancer. The encoded protein may play a selenium-dependent role in ubiquitination/deubiquitination-mediated protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]

GeneCards Summary for SELENBP1 Gene

SELENBP1 (Selenium Binding Protein 1) is a Protein Coding gene. Among its related pathways are Selenium Metabolism and Selenoproteins. GO annotations related to this gene include selenium binding.

UniProtKB/Swiss-Prot for SELENBP1 Gene

  • Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity).

Gene Wiki entry for SELENBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELENBP1 Gene

Genomics for SELENBP1 Gene

Genomic Location for SELENBP1 Gene

Start:
151,364,302 bp from pter
End:
151,372,734 bp from pter
Size:
8,433 bases
Orientation:
Minus strand

Genomic View for SELENBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SELENBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELENBP1 Gene

Regulatory Elements for SELENBP1 Gene

Proteins for SELENBP1 Gene

  • Protein details for SELENBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13228-SBP1_HUMAN
    Recommended name:
    Selenium-binding protein 1
    Protein Accession:
    Q13228
    Secondary Accessions:
    • A6NML9
    • A6PVW9
    • B2RDR3
    • B4DKP6
    • B4E1F3
    • Q49AQ8
    • Q96GX7

    Protein attributes for SELENBP1 Gene

    Size:
    472 amino acids
    Molecular mass:
    52391 Da
    Quaternary structure:
    • Interacts with USP33.

    Alternative splice isoforms for SELENBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SELENBP1 Gene

Proteomics data for SELENBP1 Gene at MOPED

Post-translational modifications for SELENBP1 Gene

No data available for DME Specific Peptides for SELENBP1 Gene

Domains for SELENBP1 Gene

Protein Domains for SELENBP1 Gene

UniProtKB/Swiss-Prot:

SBP1_HUMAN
Family:
  • Belongs to the selenium-binding protein family.:
    • Q13228
genes like me logo Genes that share domains with SELENBP1: view

No data available for Gene Families for SELENBP1 Gene

Function for SELENBP1 Gene

Molecular function for SELENBP1 Gene

GENATLAS Biochemistry: selenium binding protein,56kDa,expressed in heart muscle and other tissues
UniProtKB/Swiss-Prot Function: Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity).
UniProtKB/Swiss-Prot Induction: Down-regulated by androgen in prostate cancer cells.

Gene Ontology (GO) - Molecular Function for SELENBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19118533
GO:0008430 selenium binding IEA --
genes like me logo Genes that share ontologies with SELENBP1: view
genes like me logo Genes that share phenotypes with SELENBP1: view

Animal Models for SELENBP1 Gene

MGI Knock Outs for SELENBP1:

miRNA for SELENBP1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SELENBP1 Gene

Localization for SELENBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELENBP1 Gene

Nucleus. Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Note=May associate with Golgi membrane. May associate with the membrane of autophagosomes (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SELENBP1 Gene COMPARTMENTS Subcellular localization image for SELENBP1 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SELENBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005634 nucleus --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with SELENBP1: view

Pathways for SELENBP1 Gene

genes like me logo Genes that share pathways with SELENBP1: view

Pathways by source for SELENBP1 Gene

1 BioSystems pathway for SELENBP1 Gene

Gene Ontology (GO) - Biological Process for SELENBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SELENBP1: view

Compounds for SELENBP1 Gene

(1) HMDB Compounds for SELENBP1 Gene

Compound Synonyms Cas Number PubMed IDs
Selenium
  • selenium
7782-49-2

(2) Novoseek inferred chemical compound relationships for SELENBP1 Gene

Compound -log(P) Hits PubMed IDs
sp(1-7) 84.9 1
selenium 71.4 24
genes like me logo Genes that share compounds with SELENBP1: view

Transcripts for SELENBP1 Gene

Unigene Clusters for SELENBP1 Gene

Selenium binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SELENBP1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - -
SP6: - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - -
SP10: - - - - -
SP11: - - - - - - - - - - - - -
SP12: - - - - - - - - - - -
SP13: - - -
SP14: - -
SP15: - - - - - -
SP16: - - - - -
SP17: - - - - - - - -
SP18: - -
SP19: - - -
SP20: - - - - -
SP21:
SP22: -

ExUns: 12a · 12b ^ 13a · 13b ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for SELENBP1 Gene

GeneLoc Exon Structure for
SELENBP1
ECgene alternative splicing isoforms for
SELENBP1

Expression for SELENBP1 Gene

mRNA expression in normal human tissues for SELENBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SELENBP1 Gene

This gene is overexpressed in Colon - Transverse (12.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SELENBP1 Gene

SOURCE GeneReport for Unigene cluster for SELENBP1 Gene Hs.632460

mRNA Expression by UniProt/SwissProt for SELENBP1 Gene

Q13228-SBP1_HUMAN
Tissue specificity: Highly expressed in liver, lung, colon, prostate, kidney and pancreas. In brain, present both in neurons and glia (at protein level). Down-regulated in lung adenocarcinoma, colorectal carcinoma and ovarian cancer. Two-fold up-regulated in brain and blood from schizophrenia patients.
genes like me logo Genes that share expressions with SELENBP1: view

Orthologs for SELENBP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SELENBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SELENBP1 36
  • 99.29 (n)
  • 99.03 (a)
SELENBP1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SELENBP1 36
  • 89.6 (n)
  • 91.08 (a)
SELENBP1 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SELENBP1 36
  • 90.02 (n)
  • 92.36 (a)
SELENBP1 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Selenbp1 36
  • 86.34 (n)
  • 87.69 (a)
Selenbp1 16
Selenbp1 37
  • 88 (a)
OneToMany
Selenbp2 37
  • 87 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SELENBP1 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SELENBP1 37
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Selenbp1 36
  • 87.33 (n)
  • 89.38 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 73 (a)
OneToMany
-- 37
  • 64 (a)
OneToMany
SELENBP1 36
  • 72.41 (n)
  • 76.17 (a)
SELENBP1 37
  • 76 (a)
OneToMany
SELENBP1 37
  • 76 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 59 (a)
OneToMany
-- 37
  • 58 (a)
OneToMany
-- 37
  • 59 (a)
OneToMany
-- 37
  • 59 (a)
OneToMany
-- 37
  • 59 (a)
OneToMany
-- 37
  • 63 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.4889 36
tropical clawed frog
(Silurana tropicalis)
Amphibia selenbp1 36
  • 73.19 (n)
  • 76.38 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3726 36
zebrafish
(Danio rerio)
Actinopterygii selenbp1 36
  • 70.4 (n)
  • 74.51 (a)
selenbp1 37
  • 75 (a)
OneToOne
zgc65844 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011531 36
  • 58.85 (n)
  • 57.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7966 36
  • 57.22 (n)
  • 53.9 (a)
CG7966 37
  • 51 (a)
OneToOne
CG7966 38
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y37A1B.5 36
  • 54.06 (n)
  • 53.91 (a)
R11G10.2 37
  • 31 (a)
OneToMany
Y37A1B.5 37
  • 53 (a)
OneToMany
R11G10.2 38
  • 35 (a)
Y37A1B.5 38
  • 51 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1445 36
soybean
(Glycine max)
eudicotyledons Gma.8462 36
thale cress
(Arabidopsis thaliana)
eudicotyledons SBP3 36
  • 58.39 (n)
  • 61.67 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.763 36
corn
(Zea mays)
Liliopsida Zm.7068 36
rice
(Oryza sativa)
Liliopsida Os.8353 36
Os01g0916400 36
  • 59.26 (n)
  • 61.22 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.22952 36
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2769 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 61 (a)
OneToOne
Species with no ortholog for SELENBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SELENBP1 Gene

ENSEMBL:
Gene Tree for SELENBP1 (if available)
TreeFam:
Gene Tree for SELENBP1 (if available)

Paralogs for SELENBP1 Gene

Selected SIMAP similar genes for SELENBP1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with SELENBP1: view

No data available for Paralogs for SELENBP1 Gene

Variants for SELENBP1 Gene

Sequence variations from dbSNP and Humsavar for SELENBP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs744459 -- 151,368,941(-) GTCTA(C/T)GGGCA intron-variant
rs874751 -- 151,373,944(-) GGGGA(C/T)AAGAG upstream-variant-2KB
rs1043849 -- 151,369,125(-) CACCT(A/G)CAGCA intron-variant, missense, reference
rs1043857 -- 151,368,276(-) GGCCT(G/T)TCTCC missense, reference
rs1043860 -- 151,366,334(-) ACGCT(A/G)CCCAA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for SELENBP1 Gene

Variant ID Type Subtype PubMed ID
nsv522840 CNV Gain 19592680
esv34461 CNV Gain 17911159
nsv831581 CNV Loss 17160897
nsv438026 CNV Loss 16468122
dgv386n71 CNV Gain 21882294
dgv128e1 CNV Complex 17122850
nsv872426 CNV Gain 21882294
nsv872427 CNV Gain 21882294
nsv872428 CNV Gain 21882294
nsv8380 CNV Gain 18304495
nsv824575 CNV Gain 20364138
nsv470737 CNV Gain 18288195
nsv818467 CNV Gain 17921354
dgv36n27 CNV Gain 19166990
nsv441714 CNV CNV 18776908

Relevant External Links for SELENBP1 Gene

HapMap Linkage Disequilibrium report
SELENBP1

Disorders for SELENBP1 Gene

(1) University of Copenhagen DISEASES for SELENBP1 Gene

(4) Novoseek inferred disease relationships for SELENBP1 Gene

Disease -log(P) Hits PubMed IDs
cancer 24.2 5
tumors 20.6 13
carcinoma 7.95 7
cancer lung 6.64 1

Relevant External Links for SELENBP1

Genetic Association Database (GAD)
SELENBP1
Human Genome Epidemiology (HuGE) Navigator
SELENBP1
genes like me logo Genes that share disorders with SELENBP1: view

No data available for UniProtKB/Swiss-Prot for SELENBP1 Gene

Publications for SELENBP1 Gene

  1. Selenium binding protein 1 in ovarian cancer. (PMID: 16380993) Huang K.-C. … Ng S.-W. (Int. J. Cancer 2006) 3 4 23
  2. Suppression of human selenium-binding protein 1 is a late event in colorectal carcinogenesis and is associated with poor survival. (PMID: 16645984) Kim H. … Kim H. (Proteomics 2006) 3 4 23
  3. Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner. (PMID: 19118533) Jeong J.Y. … Sytkowski A.J. (Biochem. Biophys. Res. Commun. 2009) 3 4 23
  4. Isolation, characterization, and chromosomal mapping of a novel cDNA clone encoding human selenium binding protein. (PMID: 9027582) Chang P.W.G. … Fung K. (J. Cell. Biochem. 1997) 2 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for SELENBP1 Gene

Sources for SELENBP1 Gene

Back to Top

Content