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Aliases for SELENBP1 Gene

Aliases for SELENBP1 Gene

  • Selenium Binding Protein 1 2 3 5
  • 56 KDa Selenium-Binding Protein 3 4
  • SBP56 3 4
  • SP56 3 4
  • Epididymis Secretory Sperm Binding Protein Li 134P 3
  • Selenium-Binding Protein 1 3
  • HEL-S-134P 3
  • LPSB 3
  • HSBP 3
  • SBP 4

External Ids for SELENBP1 Gene

Previous GeneCards Identifiers for SELENBP1 Gene

  • GC01M149178
  • GC01M147084
  • GC01M148111
  • GC01M148554
  • GC01M148555
  • GC01M148149
  • GC01M149603
  • GC01M122714

Summaries for SELENBP1 Gene

Entrez Gene Summary for SELENBP1 Gene

  • This gene encodes a member of the selenium-binding protein family. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. The effects of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins, and decreased expression of this gene may be associated with several types of cancer. The encoded protein may play a selenium-dependent role in ubiquitination/deubiquitination-mediated protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]

GeneCards Summary for SELENBP1 Gene

SELENBP1 (Selenium Binding Protein 1) is a Protein Coding gene. Diseases associated with SELENBP1 include Tonsil Cancer and Schizophrenia. Among its related pathways are Selenium Metabolism and Selenoproteins and IL1 and megakaryocytes in obesity. GO annotations related to this gene include selenium binding.

UniProtKB/Swiss-Prot for SELENBP1 Gene

  • Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity).

Gene Wiki entry for SELENBP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELENBP1 Gene

Genomics for SELENBP1 Gene

Regulatory Elements for SELENBP1 Gene

Enhancers for SELENBP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G151398 1.1 ENCODE 26.8 -27.4 -27372 3.0 HDGF PKNOX1 FOXA2 ARNT WRNIP1 ARID4B SIN3A DMAP1 YBX1 FEZF1 SETDB1 SELENBP1 GABPB2 UBE2D3P3 GOLPH3L CTSK MRPL9 LYSMD1 RN7SL444P ENSG00000229021
GH01G151456 1.1 ENCODE 22.6 -85.7 -85722 3.6 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 ZNF766 SELENBP1 GOLPH3L POGZ RNY4P25
GH01G151472 1.4 FANTOM5 Ensembl ENCODE 16.8 -100.5 -100526 1.5 CBX3 ATF1 CREB3L1 RAD21 ZBTB7B ZNF121 ELK1 EGR1 CREM NCOA1 SELENBP1 CGN ENSG00000252840 TUFT1 ENSG00000232536 CELF3 LINGO4 THEM5 OAZ3 C1orf56
GH01G151308 2 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +60.8 60798 6.1 CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MRPL9 GABPB2 SETDB1 GOLPH3L LYSMD1 PRPF3 UBE2D3P3 ZNF687 ADAMTSL4 RFX5
GH01G151193 2 FANTOM5 Ensembl ENCODE dbSUPER 9.6 +175.1 175088 7.7 CREB3L1 DMAP1 YY1 ZNF143 ZNF263 NFYC NR2C1 NBN KDM1A SP7 LYSMD1 SETDB1 BNIPL PSMD4 GOLPH3L PRPF3 UBE2D3P3 TMOD4 MRPL9 RPS10P6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SELENBP1 on UCSC Golden Path with GeneCards custom track

Promoters for SELENBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000013614 134 401 FOXA2 ARID4B SIN3A FEZF1 ZNF2 GLIS2 ELK1 SP3 SP5 ZNF579

Genomic Location for SELENBP1 Gene

Chromosome:
1
Start:
151,364,302 bp from pter
End:
151,372,734 bp from pter
Size:
8,433 bases
Orientation:
Minus strand

Genomic View for SELENBP1 Gene

Genes around SELENBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELENBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELENBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELENBP1 Gene

Proteins for SELENBP1 Gene

  • Protein details for SELENBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13228-SBP1_HUMAN
    Recommended name:
    Selenium-binding protein 1
    Protein Accession:
    Q13228
    Secondary Accessions:
    • A6NML9
    • A6PVW9
    • B2RDR3
    • B4DKP6
    • B4E1F3
    • Q49AQ8
    • Q96GX7

    Protein attributes for SELENBP1 Gene

    Size:
    472 amino acids
    Molecular mass:
    52391 Da
    Quaternary structure:
    • Interacts with USP33.

    Alternative splice isoforms for SELENBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SELENBP1 Gene

Post-translational modifications for SELENBP1 Gene

No data available for DME Specific Peptides for SELENBP1 Gene

Domains & Families for SELENBP1 Gene

Protein Domains for SELENBP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13228

UniProtKB/Swiss-Prot:

SBP1_HUMAN :
  • Belongs to the selenium-binding protein family.
Family:
  • Belongs to the selenium-binding protein family.
genes like me logo Genes that share domains with SELENBP1: view

No data available for Gene Families for SELENBP1 Gene

Function for SELENBP1 Gene

Molecular function for SELENBP1 Gene

GENATLAS Biochemistry:
selenium binding protein,56kDa,expressed in heart muscle and other tissues
UniProtKB/Swiss-Prot Function:
Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity).
UniProtKB/Swiss-Prot Induction:
Down-regulated by androgen in prostate cancer cells.

Gene Ontology (GO) - Molecular Function for SELENBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008430 selenium binding IEA --
genes like me logo Genes that share ontologies with SELENBP1: view

Phenotypes for SELENBP1 Gene

genes like me logo Genes that share phenotypes with SELENBP1: view

Animal Model Products

CRISPR Products

miRNA for SELENBP1 Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SELENBP1 Gene

Localization for SELENBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELENBP1 Gene

Nucleus. Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Note=May associate with Golgi membrane (By similarity). May associate with the membrane of autophagosomes (By similarity). {ECO:0000250 UniProtKB:Q8VIF7}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELENBP1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
plasma membrane 1
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SELENBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005615 extracellular space IDA 16502470
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SELENBP1: view

Pathways & Interactions for SELENBP1 Gene

genes like me logo Genes that share pathways with SELENBP1: view

Pathways by source for SELENBP1 Gene

Gene Ontology (GO) - Biological Process for SELENBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SELENBP1: view

No data available for SIGNOR curated interactions for SELENBP1 Gene

Drugs & Compounds for SELENBP1 Gene

(1) Drugs for SELENBP1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Selenium Approved, Vet_approved Pharma 180

(1) Additional Compounds for SELENBP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SELENBP1: view

Transcripts for SELENBP1 Gene

Unigene Clusters for SELENBP1 Gene

Selenium binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELENBP1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - -
SP6: - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - -
SP10: - - - - -
SP11: - - - - - - - - - - - - -
SP12: - - - - - - - - - - -
SP13: - - -
SP14: - -
SP15: - - - - - -
SP16: - - - - -
SP17: - - - - - - - -
SP18: - -
SP19: - - -
SP20: - - - - -
SP21:
SP22: -

ExUns: 12a · 12b ^ 13a · 13b ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for SELENBP1 Gene

GeneLoc Exon Structure for
SELENBP1
ECgene alternative splicing isoforms for
SELENBP1

Expression for SELENBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SELENBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SELENBP1 Gene

This gene is overexpressed in Colon - Transverse (x12.9).

Protein differential expression in normal tissues from HIPED for SELENBP1 Gene

This gene is overexpressed in Liver, secretome (8.0) and Nasal epithelium (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SELENBP1 Gene



Protein tissue co-expression partners for SELENBP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SELENBP1 Gene:

SELENBP1

SOURCE GeneReport for Unigene cluster for SELENBP1 Gene:

Hs.632460

mRNA Expression by UniProt/SwissProt for SELENBP1 Gene:

Q13228-SBP1_HUMAN
Tissue specificity: Highly expressed in liver, lung, colon, prostate, kidney and pancreas. In brain, present both in neurons and glia (at protein level). Down-regulated in lung adenocarcinoma, colorectal carcinoma and ovarian cancer. Two-fold up-regulated in brain and blood from schizophrenia patients.

Evidence on tissue expression from TISSUES for SELENBP1 Gene

  • Intestine(4.9)
  • Nervous system(4.9)
  • Liver(4.7)
  • Lung(4.7)
  • Heart(4.6)
  • Blood(3.6)
  • Kidney(2.6)
  • Muscle(2.1)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with SELENBP1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SELENBP1 Gene

Orthologs for SELENBP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SELENBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SELENBP1 34 35
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia SELENBP1 34 35
  • 90.02 (n)
cow
(Bos Taurus)
Mammalia SELENBP1 34 35
  • 89.6 (n)
rat
(Rattus norvegicus)
Mammalia Selenbp1 34
  • 87.33 (n)
mouse
(Mus musculus)
Mammalia Selenbp2 16 35
  • 87 (a)
Selenbp1 34 35
  • 86.34 (n)
oppossum
(Monodelphis domestica)
Mammalia SELENBP1 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SELENBP1 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 73 (a)
OneToMany
SELENBP1 34 35 35
  • 72.41 (n)
-- 35
  • 64 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 63 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia selenbp1 34
  • 73.19 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4889 34
zebrafish
(Danio rerio)
Actinopterygii selenbp1 34 35
  • 70.4 (n)
zgc65844 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3726 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011531 34
  • 58.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7966 36 34 35
  • 57.22 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y37A1B.5 34
  • 54.06 (n)
Y37A1B.5 36 35
  • 51 (a)
R11G10.2 36 35
  • 35 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SBP3 34
  • 58.39 (n)
soybean
(Glycine max)
eudicotyledons Gma.8462 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1445 34
rice
(Oryza sativa)
Liliopsida Os01g0916400 34
  • 59.26 (n)
Os.8353 34
barley
(Hordeum vulgare)
Liliopsida Hv.763 34
wheat
(Triticum aestivum)
Liliopsida Ta.22952 34
corn
(Zea mays)
Liliopsida Zm.7068 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 61 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2769 34
Species where no ortholog for SELENBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SELENBP1 Gene

ENSEMBL:
Gene Tree for SELENBP1 (if available)
TreeFam:
Gene Tree for SELENBP1 (if available)

Paralogs for SELENBP1 Gene

(1) SIMAP similar genes for SELENBP1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with SELENBP1: view

No data available for Paralogs for SELENBP1 Gene

Variants for SELENBP1 Gene

Sequence variations from dbSNP and Humsavar for SELENBP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000890101 -- 151,370,871(+) CTGGG(G/T)CCTGG intron-variant
rs1000965504 -- 151,370,041(+) AGCCG(A/G)GGTCG intron-variant
rs1001789655 -- 151,366,011(+) CAGGG(A/G)TTGTG intron-variant
rs1001937682 -- 151,371,760(+) TGCAG(A/C)CTCGG intron-variant
rs1001991988 -- 151,371,275(+) TACAG(A/G)CATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SELENBP1 Gene

Variant ID Type Subtype PubMed ID
dgv36n27 CNV gain 19166990
dgv53e214 CNV gain 21293372
dgv564n54 CNV gain 21841781
esv2758969 CNV gain 17122850
esv34461 CNV gain 17911159
esv3587525 CNV gain 21293372
esv3587526 CNV loss 21293372
esv3894200 CNV gain 25118596
nsv1161560 CNV duplication 26073780
nsv438026 CNV loss 16468122
nsv441714 CNV gain 18776908
nsv470737 CNV gain 18288195
nsv522840 CNV gain 19592680
nsv818467 CNV gain 17921354
nsv824575 CNV gain 20364138
nsv831581 CNV loss 17160897
nsv8380 CNV gain 18304495

Variation tolerance for SELENBP1 Gene

Residual Variation Intolerance Score: 67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 53.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELENBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELENBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELENBP1 Gene

Disorders for SELENBP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SELENBP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
tonsil cancer
  • malignant neoplasm of faucial tonsil
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SELENBP1

Genetic Association Database (GAD)
SELENBP1
Human Genome Epidemiology (HuGE) Navigator
SELENBP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENBP1
genes like me logo Genes that share disorders with SELENBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SELENBP1 Gene

Publications for SELENBP1 Gene

  1. Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner. (PMID: 19118533) Jeong J.Y. … Sytkowski A.J. (Biochem. Biophys. Res. Commun. 2009) 3 4 22 64
  2. Selenium binding protein 1 in ovarian cancer. (PMID: 16380993) Huang K.-C. … Ng S.-W. (Int. J. Cancer 2006) 3 4 22 64
  3. Suppression of human selenium-binding protein 1 is a late event in colorectal carcinogenesis and is associated with poor survival. (PMID: 16645984) Kim H. … Kim H. (Proteomics 2006) 3 4 22 64
  4. Isolation, characterization, and chromosomal mapping of a novel cDNA clone encoding human selenium binding protein. (PMID: 9027582) Chang P.W.G. … Fung K. (J. Cell. Biochem. 1997) 2 3 4 64
  5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty S.E. … . (PLoS Genet. 2010) 3 46 64

Products for SELENBP1 Gene

Sources for SELENBP1 Gene

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