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SELENBP1 Gene

protein-coding   GIFtS: 62
GCID: GC01M151339

Selenium Binding Protein 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Selenium Binding Protein 11 2     LPSB2
SP562 3 5     Epididymis Secretory Sperm Binding Protein Li 134P2
56 KDa Selenium-Binding Protein2 3     hSBP2
SBP562 3     Selenium-Binding Protein 12
HEL-S-134P2     SBP3

External Ids:    HGNC: 107191   Entrez Gene: 89912   Ensembl: ENSG000001434167   OMIM: 6041885   UniProtKB: Q132283   

Export aliases for SELENBP1 gene to outside databases

Previous GC identifers: GC01M149178 GC01M147084 GC01M148111 GC01M148554 GC01M148555 GC01M148149 GC01M149603 GC01M122714


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SELENBP1 Gene:
This gene encodes a member of the selenium-binding protein family. Selenium is an essential nutrient that exhibits
potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. The effects
of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins, and
decreased expression of this gene may be associated with several types of cancer. The encoded protein may play a
selenium-dependent role in ubiquitination/deubiquitination-mediated protein degradation. Alternatively spliced
transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Apr 2012)

GeneCards Summary for SELENBP1 Gene:
SELENBP1 (selenium binding protein 1) is a protein-coding gene. GO annotations related to this gene include selenium binding.

UniProtKB/Swiss-Prot: SBP1_HUMAN, Q13228
Function: Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm.
May be involved in intra-Golgi protein transport (By similarity)

Gene Wiki entry for SELENBP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the SELENBP1 gene promoter:
         COUP-TF1   CREB   COUP-TF   deltaCREB   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSELENBP1 promoter sequence
   Search Chromatin IP Primers for SELENBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SELENBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.3

SELENBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SELENBP1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M151339:  view genomic region     (about GC identifiers)

Start:
151,336,778 bp from pter      End:
151,345,209 bp from pter
Size:
8,432 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SBP1_HUMAN, Q13228 (See protein sequence)
Recommended Name: Selenium-binding protein 1  
Size: 472 amino acids; 52391 Da
Subunit: Interacts with USP33
Sequence caution: Sequence=BAG59258.1; Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: A6NML9 B2RDR3 B4DKP6 B4E1F3 Q49AQ8 Q96GX7
Alternative splicing: 3 isoforms:  Q13228-1   Q13228-2   Q13228-3   

Explore the universe of human proteins at neXtProt for SELENBP1: NX_Q13228

Explore proteomics data for SELENBP1 at MOPED

Post-translational modifications: 

  • Phosphorylated (Probable)1
  • The N-terminus is blocked (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SELENBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001245217.1  NP_001245218.1  NP_003935.2  

    ENSEMBL proteins: 
     ENSP00000357861   ENSP00000413960   ENSP00000397261   ENSP00000402531   ENSP00000395637  
     ENSP00000412816   ENSP00000416206   ENSP00000396209   ENSP00000406222   ENSP00000390433  
     ENSP00000400841   ENSP00000408263  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR008826 Se-bd
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q13228

    ProtoNet protein and cluster: Q13228

    1 Blocks protein domain: IPB008826 56kDa selenium binding

    UniProtKB/Swiss-Prot: SBP1_HUMAN, Q13228
    Similarity: Belongs to the selenium-binding protein family


    Find genes that share domains with SELENBP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SBP1_HUMAN, Q13228
    Function: Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm.
    May be involved in intra-Golgi protein transport (By similarity)
    Induction: Down-regulated by androgen in prostate cancer cells

         Genatlas biochemistry entry for SELENBP1:
    selenium binding protein,56kDa,expressed in heart muscle and other tissues

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19118533
    GO:0008430selenium binding IEA--
         
    Find genes that share ontologies with SELENBP1           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Selenbp1):
     endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     nervous system  reproductive system 

    Find genes that share phenotypes with SELENBP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Selenbp1tm1Hyama for SELENBP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SELENBP1
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    miRTarBase miRNAs that target SELENBP1:
    hsa-mir-92a-3p (MIRT049678), hsa-mir-26b-5p (MIRT029152), hsa-mir-20a-5p (MIRT050594), hsa-mir-335-5p (MIRT017378)

    Block miRNA regulation of human, mouse, rat SELENBP1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SELENBP1:
    hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidSELENBP1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELENBP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SBP1_HUMAN, Q13228: Nucleus. Cytoplasm, cytosol. Membrane; Peripheral membrane protein (By similarity). Note=May
    associate with Golgi membrane. May associate with the membrane of autophagosomes (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    cytoskeleton1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005730nucleolus ----
    GO:0005829cytosol IEA--
    GO:0016020membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with SELENBP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SELENBP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Selenium Metabolism and Selenoproteins
    Selenium Metabolism and Selenoproteins


    1 BioSystems Pathway for SELENBP1
        Selenium Metabolism and Selenoproteins



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SELENBP1
    Interactions:

        GeneGlobe Interaction Network for SELENBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for SELENBP1 (Q132281, 2, 3 ENSP000003578614) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLDIP2Q9Y2S72, 3MINT-65167 I2D: score=5 
    RPA1P276942, 3MINT-65165 I2D: score=5 
    LRIF1Q5T3J32, 3MINT-65166 I2D: score=4 
    EEDO755302, 3MINT-8270033 I2D: score=2 
    MED31Q9Y3C72, 3, ENSP000002257284MINT-65168 MINT-8270055 I2D: score=5 STRING: ENSP00000225728
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--

    Find genes that share ontologies with SELENBP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SELENBP1 (SBP1)

    1 HMDB Compound for SELENBP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Seleniumselenium (see all 5)7782-49-2--

    2 Novoseek inferred chemical compound relationships for SELENBP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sp(1-7) 84.9 1 9780359 (1)
    selenium 71.4 47 19896693 (8), 20332323 (4), 16380993 (2), 14991897 (2) (see all 11)



    Find genes that share compounds with SELENBP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SELENBP1 gene (3 alternative transcripts): 
    NM_001258288.1  NM_001258289.1  NM_003944.3  

    Unigene Cluster for SELENBP1:

    Selenium binding protein 1
    Hs.632460  [show with all ESTs]
    Unigene Representative Sequence: NM_001258289
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000368868(uc001exx.3 uc010pcz.2) ENST00000493560 ENST00000447402
    ENST00000426705 ENST00000474352(uc001eya.3) ENST00000443708 ENST00000470345
    ENST00000455397 ENST00000427977 ENST00000423070 ENST00000463664 ENST00000424475
    ENST00000458566 ENST00000455839 ENST00000465273 ENST00000473693 ENST00000492643
    ENST00000498494
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    1 qRT-PCR Assays for microRNA that regulate SELENBP1:
    hsa-miR-578
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    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SELENBP1
      QuantiFast Probe-based Assays in human, mouse, rat SELENBP1

    Additional mRNA sequence: 

    AK296661.1 AK298355.1 AK303815.1 AK310044.1 AK315643.1 BC009084.1 CR456852.1 U29091.1 

    Selected DOTS entries (see all 30):

    DT.456187  DT.100857440  DT.97847992  DT.100857441  DT.97847993  DT.101985014  DT.121350680  DT.100857450 
    DT.121350707  DT.101985013  DT.86857123  DT.92443283  DT.121350704  DT.121350685  DT.92443306  DT.95311371 
    DT.100771340  DT.121350681  DT.121350741  DT.95373468  DT.95373469  DT.95373475  DT.100857439  DT.100857451 

    Selected AceView cDNA sequences (see all 450):

    BU689556 CB163580 BC009084 CB163712 BU741746 AK023875 CF145821 CD671787 
    AI884468 BM696531 AW152429 AL531460 BQ943876 BI757798 AA262985 BP338521 
    BF756619 CR612007 AW949750 AL529475 AW675314 CB215407 BM791015 BP381402 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SELENBP1 (see all 22)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^
    SP1:        -     -     -                       -     -                                   -     -     -                                                         
    SP2:        -     -     -                                                                 -     -     -                                                         
    SP3:        -     -     -                                                                 -     -     -                                                         
    SP4:        -     -     -           -     -     -     -     -     -     -                 -     -     -                       -     -                           
    SP5:        -     -     -                       -     -                                   -     -     -     -     -     -     -     -     -     -               

    ExUns: 12a · 12b ^ 13a · 13b ^ 14
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for SELENBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SELENBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCTCTTGGA
    SELENBP1 Expression
    About this image


    SELENBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Ovary (Reproductive System)
             Oviduct
     
     Adipose (Muscoskeletal System)
             HyStem+BMP4-induced 7SMOO32 cells
     
     Epithelial Cells
             Fetal Matrix Cells Hair Follicle
    SELENBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SELENBP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632460

    UniProtKB/Swiss-Prot: SBP1_HUMAN, Q13228
    Tissue specificity: Highly expressed in liver, lung, colon, prostate, kidney and pancreas. In brain, present both
    in neurons and glia (at protein level). Down-regulated in lung adenocarcinoma, colorectal carcinoma and ovarian
    cancer. Two-fold up-regulated in brain and blood from schizophrenia patients

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SELENBP1 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Selenbp11 , 5 selenium binding protein 11, 5 86.34(n)1
    87.69(a)1
      3 (40.74 cM)5
    203411  NM_009150.31  NP_033176.21 
     949330565 
    chicken
    (Gallus gallus)
    Aves SELENBP11 selenium binding protein 1 72.41(n)
    76.17(a)
      425664  NM_001277810.1  NP_001264739.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 6)
    Uncharacterized protein
    (see all 6)
    63(a)
    59(a)
    (see all 6)
    many → 1
    many → 1
    (see all 6)
    GL343779.1(66135-80351)
    AAWZ02040201(1235-4963)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.48892 Xenopus laevis transcribed sequence with moderate similarity more 80.9(n)    CD360184.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc658442 hypothetical protein MGC65844 77.11(n)   393542  BC056590.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG79661 , 3 selenium binding3
    CG79661
    51(a)3
    57.22(n)1
    53.9(a)1
      87D103
    416101  NM_141999.31  NP_650256.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y37A1B.53
    CELE_Y37A1B.51
    CELE_Y37A1B.51 51(a)
    (best of 2)3
    54.06(n)1
    53.91(a)1
      IV(14051136-14053335)3
    1783601  NM_001268848.11  NP_001255777.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SBP31 SBP3 58.39(n)
    61.67(a)
      821962  NM_113284.2  NP_189022.1 
    rice
    (Oryza sativa)
    Liliopsida Os.83532 Oryza sativa Os SBP mRNA for putative selenium binding more 73.84(n)    AK071710.1 


    ENSEMBL Gene Tree for SELENBP1 (if available)
    TreeFam Gene Tree for SELENBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SELENBP1 gene
    1 SIMAP similar gene for SELENBP1 using alignment to 9 protein entries:     SBP1_HUMAN (see all proteins):
    MAP3K6

    Find genes that share paralogs with SELENBP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SELENBP1 (see all 324)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1507998291,2
    --151336469(+) ATTCTC/TTTGAG 3 -- ds50010--------
    rs1394509041,2
    --151336528(+) AAAAAA/CCCAAA 3 -- ds50010--------
    rs1897451951,2
    --151336603(+) TTTCAA/GATTTT 3 -- ds50010--------
    rs1140916911,2
    F--151336635(+) TTGGGC/AATTAT 3 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1808223881,2
    --151336763(+) GGCCCC/TCAAAG 3 -- ds50010--------
    rs1837347051,2
    --151336851(+) GCAACA/GAGCAA 3 -- ut310--------
    rs1163965901,2
    C--151337045(+) ACAATC/TGCCCC 6 N D mis11Minor allele frequency- T:0.01WA 118
    rs2002067351,2
    --151337059(+) GGTAGC/TGGAGC 6 H R mis10--------
    rs2004614851,2
    C--151337060(+) GTAGCA/GGAGCT 6 R C mis10--------
    rs2014607651,2
    --151337100(+) TTCCCA/GAAGTC 6 F syn10--------

    HapMap Linkage Disequilibrium report for SELENBP1 (151336778 - 151345209 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SELENBP1 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv438026CNV Loss16468122
    nsv831581CNV Loss17160897
    nsv470737CNV Gain18288195
    dgv386n71CNV Gain21882294
    nsv818467CNV Gain17921354
    nsv872427CNV Gain21882294
    nsv824575CNV Gain20364138
    nsv872428CNV Gain21882294
    dgv36n27CNV Gain19166990
    esv34461CNV Gain17911159

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SELENBP1
    DNA2.0 Custom Variant and Variant Library Synthesis for SELENBP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604188    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for SELENBP1:
    Hypertension

    Find genes that share disorders with SELENBP1           About GenesLikeMe

    4 Novoseek inferred disease relationships for SELENBP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 24.2 8 18272210 (2), 19896693 (1), 19924303 (1), 19276359 (1)
    tumors 20.6 39 18272210 (6), 19896693 (5), 19422301 (1), 15378696 (1)
    carcinoma 7.95 12 19896693 (5), 16645984 (2)
    cancer lung 6.64 1 15378762 (1)

    Genetic Association Database (GAD): SELENBP1
    Human Genome Epidemiology (HuGE) Navigator: SELENBP1 (3 documents)

    Export disorders for SELENBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SELENBP1 gene, integrated from 10 sources (see all 66):
    (articles sorted by number of sources associating them with SELENBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, characterization, and chromosomal mapping of a novel cDNA clone encoding human selenium binding protein. (PubMed id 9027582)1, 2, 3 Chang P.W.G.... Fung K. (J. Cell. Biochem. 1997)
    2. Suppression of human selenium-binding protein 1 is a late event in colorectal carcinogenesis and is associated with poor survival. (PubMed id 16645984)1, 2, 9 Kim H.... Kim H. (Proteomics 2006)
    3. Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner. (PubMed id 19118533)1, 2, 9 Jeong J.Y.... Sytkowski A.J. (Biochem. Biophys. Res. Commun. 2009)
    4. Selenium binding protein 1 in ovarian cancer. (PubMed id 16380993)1, 2, 9 Huang K.-C.... Ng S.-W. (Int. J. Cancer 2006)
    5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    6. Family-based association study of SELENBP1 in schizophrenia. (PubMed id 19596560)1, 4 Kanazawa T....Tsuang M.T. (Schizophr. Res. 2009)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Progressive loss of selenium-binding protein 1 expression correlates with increasing epithelial proliferation and papillary complexity in ovarian serous borderline tumor and low-grade serous carcinoma. (PubMed id 19896693)1, 9 Zhang C....Lawrence W.D. (Hum. Pathol. 2010)
    9. Decreased selenium-binding protein 1 in esophageal adenocarcinoma results from posttranscriptional and epigenetic regulation and affects chemosensitivity. (PubMed id 20332323)1, 9 Silvers A.L....Chang A.C. (Clin. Cancer Res. 2010)
    10. Transcriptional regulation and biological functions of selenium-binding protein 1 in colorectal cancer in vitro and in nude mouse xenografts. (PubMed id 19924303)1, 9 Pohl N.M....Yang W. (PLoS ONE 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8991 HGNC: 10719 AceView: SELENBP1 Ensembl:ENSG00000143416 euGenes: HUgn8991
    ECgene: SELENBP1 H-InvDB: SELENBP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SELENBP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SELENBP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SELENBP1 gene:
    Search GeneIP for patents involving SELENBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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