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Aliases for SELENBP1 Gene

Aliases for SELENBP1 Gene

  • Selenium Binding Protein 1 2 3 5
  • 56 KDa Selenium-Binding Protein 3 4
  • SBP56 3 4
  • SP56 3 4
  • Epididymis Secretory Sperm Binding Protein Li 134P 3
  • Selenium-Binding Protein 1 3
  • HEL-S-134P 3
  • LPSB 3
  • HSBP 3
  • SBP 4

External Ids for SELENBP1 Gene

Previous GeneCards Identifiers for SELENBP1 Gene

  • GC01M149178
  • GC01M147084
  • GC01M148111
  • GC01M148554
  • GC01M148555
  • GC01M148149
  • GC01M149603
  • GC01M122714

Summaries for SELENBP1 Gene

Entrez Gene Summary for SELENBP1 Gene

  • This gene encodes a member of the selenium-binding protein family. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. The effects of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins, and decreased expression of this gene may be associated with several types of cancer. The encoded protein may play a selenium-dependent role in ubiquitination/deubiquitination-mediated protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]

GeneCards Summary for SELENBP1 Gene

SELENBP1 (Selenium Binding Protein 1) is a Protein Coding gene. Diseases associated with SELENBP1 include Schizophrenia and Tonsil Cancer. Among its related pathways are Selenium Metabolism and Selenoproteins. GO annotations related to this gene include selenium binding.

UniProtKB/Swiss-Prot for SELENBP1 Gene

  • Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity).

Gene Wiki entry for SELENBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELENBP1 Gene

Genomics for SELENBP1 Gene

Regulatory Elements for SELENBP1 Gene

Enhancers for SELENBP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SELENBP1 on UCSC Golden Path with GeneCards custom track

Promoters for SELENBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SELENBP1 Gene

Chromosome:
1
Start:
151,364,302 bp from pter
End:
151,372,734 bp from pter
Size:
8,433 bases
Orientation:
Minus strand

Genomic View for SELENBP1 Gene

Genes around SELENBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELENBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELENBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELENBP1 Gene

Proteins for SELENBP1 Gene

  • Protein details for SELENBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13228-SBP1_HUMAN
    Recommended name:
    Selenium-binding protein 1
    Protein Accession:
    Q13228
    Secondary Accessions:
    • A6NML9
    • A6PVW9
    • B2RDR3
    • B4DKP6
    • B4E1F3
    • Q49AQ8
    • Q96GX7

    Protein attributes for SELENBP1 Gene

    Size:
    472 amino acids
    Molecular mass:
    52391 Da
    Quaternary structure:
    • Interacts with USP33.

    Alternative splice isoforms for SELENBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SELENBP1 Gene

Post-translational modifications for SELENBP1 Gene

No data available for DME Specific Peptides for SELENBP1 Gene

Domains & Families for SELENBP1 Gene

Protein Domains for SELENBP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13228

UniProtKB/Swiss-Prot:

SBP1_HUMAN :
  • Belongs to the selenium-binding protein family.
Family:
  • Belongs to the selenium-binding protein family.
genes like me logo Genes that share domains with SELENBP1: view

No data available for Gene Families for SELENBP1 Gene

Function for SELENBP1 Gene

Molecular function for SELENBP1 Gene

GENATLAS Biochemistry:
selenium binding protein,56kDa,expressed in heart muscle and other tissues
UniProtKB/Swiss-Prot Function:
Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity).
UniProtKB/Swiss-Prot Induction:
Down-regulated by androgen in prostate cancer cells.

Gene Ontology (GO) - Molecular Function for SELENBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19118533
GO:0008430 selenium binding IEA --
genes like me logo Genes that share ontologies with SELENBP1: view

Phenotypes for SELENBP1 Gene

genes like me logo Genes that share phenotypes with SELENBP1: view

Animal Model Products

CRISPR Products

miRNA for SELENBP1 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SELENBP1 Gene

Localization for SELENBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELENBP1 Gene

Nucleus. Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Note=May associate with Golgi membrane (By similarity). May associate with the membrane of autophagosomes (By similarity). {ECO:0000250 UniProtKB:Q8VIF7}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SELENBP1 Gene COMPARTMENTS Subcellular localization image for SELENBP1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
cytoskeleton 1
golgi apparatus 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SELENBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005730 nucleolus IDA --
GO:0005829 cytosol IEA --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SELENBP1: view

Pathways & Interactions for SELENBP1 Gene

genes like me logo Genes that share pathways with SELENBP1: view

Pathways by source for SELENBP1 Gene

1 BioSystems pathway for SELENBP1 Gene

Gene Ontology (GO) - Biological Process for SELENBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SELENBP1: view

No data available for SIGNOR curated interactions for SELENBP1 Gene

Drugs & Compounds for SELENBP1 Gene

(1) Drugs for SELENBP1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
selenium Pharma 171

(1) Additional Compounds for SELENBP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SELENBP1: view

Transcripts for SELENBP1 Gene

Unigene Clusters for SELENBP1 Gene

Selenium binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELENBP1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - -
SP6: - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - -
SP10: - - - - -
SP11: - - - - - - - - - - - - -
SP12: - - - - - - - - - - -
SP13: - - -
SP14: - -
SP15: - - - - - -
SP16: - - - - -
SP17: - - - - - - - -
SP18: - -
SP19: - - -
SP20: - - - - -
SP21:
SP22: -

ExUns: 12a · 12b ^ 13a · 13b ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for SELENBP1 Gene

GeneLoc Exon Structure for
SELENBP1
ECgene alternative splicing isoforms for
SELENBP1

Expression for SELENBP1 Gene

mRNA expression in normal human tissues for SELENBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SELENBP1 Gene

This gene is overexpressed in Colon - Transverse (x12.9).

Protein differential expression in normal tissues from HIPED for SELENBP1 Gene

This gene is overexpressed in Liver, secretome (8.0) and Nasal epithelium (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SELENBP1 Gene



Protein tissue co-expression partners for SELENBP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SELENBP1 Gene:

SELENBP1

SOURCE GeneReport for Unigene cluster for SELENBP1 Gene:

Hs.632460

mRNA Expression by UniProt/SwissProt for SELENBP1 Gene:

Q13228-SBP1_HUMAN
Tissue specificity: Highly expressed in liver, lung, colon, prostate, kidney and pancreas. In brain, present both in neurons and glia (at protein level). Down-regulated in lung adenocarcinoma, colorectal carcinoma and ovarian cancer. Two-fold up-regulated in brain and blood from schizophrenia patients.
genes like me logo Genes that share expression patterns with SELENBP1: view

Primer Products

Orthologs for SELENBP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SELENBP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SELENBP1 34
  • 89.6 (n)
  • 91.08 (a)
SELENBP1 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SELENBP1 34
  • 90.02 (n)
  • 92.36 (a)
SELENBP1 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Selenbp1 34
  • 86.34 (n)
  • 87.69 (a)
Selenbp2 16
Selenbp1 35
  • 88 (a)
OneToMany
Selenbp2 35
  • 87 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia SELENBP1 34
  • 99.29 (n)
  • 99.03 (a)
SELENBP1 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Selenbp1 34
  • 87.33 (n)
  • 89.38 (a)
oppossum
(Monodelphis domestica)
Mammalia SELENBP1 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SELENBP1 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves SELENBP1 34
  • 72.41 (n)
  • 76.17 (a)
-- 35
  • 73 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
SELENBP1 35
  • 76 (a)
OneToMany
SELENBP1 35
  • 76 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 59 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
-- 35
  • 63 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia selenbp1 34
  • 73.19 (n)
  • 76.38 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4889 34
zebrafish
(Danio rerio)
Actinopterygii selenbp1 34
  • 70.4 (n)
  • 74.51 (a)
zgc65844 34
selenbp1 35
  • 75 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3726 34
fruit fly
(Drosophila melanogaster)
Insecta CG7966 36
  • 51 (a)
CG7966 34
  • 57.22 (n)
  • 53.9 (a)
CG7966 35
  • 51 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011531 34
  • 58.85 (n)
  • 57.08 (a)
worm
(Caenorhabditis elegans)
Secernentea R11G10.2 36
  • 35 (a)
Y37A1B.5 36
  • 51 (a)
CELE_Y37A1B.5 34
  • 54.06 (n)
  • 53.91 (a)
R11G10.2 35
  • 31 (a)
OneToMany
Y37A1B.5 35
  • 53 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons SBP3 34
  • 58.39 (n)
  • 61.67 (a)
soybean
(Glycine max)
eudicotyledons Gma.8462 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1445 34
barley
(Hordeum vulgare)
Liliopsida Hv.763 34
rice
(Oryza sativa)
Liliopsida Os.8353 34
Os01g0916400 34
  • 59.26 (n)
  • 61.22 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.22952 34
corn
(Zea mays)
Liliopsida Zm.7068 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2769 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 61 (a)
OneToOne
Species where no ortholog for SELENBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SELENBP1 Gene

ENSEMBL:
Gene Tree for SELENBP1 (if available)
TreeFam:
Gene Tree for SELENBP1 (if available)

Paralogs for SELENBP1 Gene

(1) SIMAP similar genes for SELENBP1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with SELENBP1: view

No data available for Paralogs for SELENBP1 Gene

Variants for SELENBP1 Gene

Sequence variations from dbSNP and Humsavar for SELENBP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs744459 -- 151,368,941(-) GTCTA(C/T)GGGCA intron-variant, upstream-variant-2KB
rs1043849 -- 151,369,125(-) CACCT(A/G)CAGCA intron-variant, nc-transcript-variant, reference, missense
rs1043857 -- 151,368,276(-) GGCCT(G/T)TCTCC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1043860 -- 151,366,334(-) ACGCT(A/G)CCCAA intron-variant, reference, missense
rs1043861 -- 151,366,326(-) CAAGG(C/T)TTTGT intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SELENBP1 Gene

Variant ID Type Subtype PubMed ID
dgv36n27 CNV gain 19166990
dgv53e214 CNV gain 21293372
dgv564n54 CNV gain 21841781
esv2758969 CNV gain 17122850
esv34461 CNV gain 17911159
esv3587525 CNV gain 21293372
esv3587526 CNV loss 21293372
esv3894200 CNV gain 25118596
nsv1161560 CNV duplication 26073780
nsv438026 CNV loss 16468122
nsv441714 CNV gain 18776908
nsv470737 CNV gain 18288195
nsv522840 CNV gain 19592680
nsv818467 CNV gain 17921354
nsv824575 CNV gain 20364138
nsv831581 CNV loss 17160897
nsv8380 CNV gain 18304495

Variation tolerance for SELENBP1 Gene

Residual Variation Intolerance Score: 67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 53.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELENBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELENBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELENBP1 Gene

Disorders for SELENBP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SELENBP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
tonsil cancer
  • malignant neoplasm of faucial tonsil
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SELENBP1

Genetic Association Database (GAD)
SELENBP1
Human Genome Epidemiology (HuGE) Navigator
SELENBP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELENBP1
genes like me logo Genes that share disorders with SELENBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SELENBP1 Gene

Publications for SELENBP1 Gene

  1. Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner. (PMID: 19118533) Jeong J.Y. … Sytkowski A.J. (Biochem. Biophys. Res. Commun. 2009) 3 4 22 65
  2. Selenium binding protein 1 in ovarian cancer. (PMID: 16380993) Huang K.-C. … Ng S.-W. (Int. J. Cancer 2006) 3 4 22 65
  3. Suppression of human selenium-binding protein 1 is a late event in colorectal carcinogenesis and is associated with poor survival. (PMID: 16645984) Kim H. … Kim H. (Proteomics 2006) 3 4 22 65
  4. Isolation, characterization, and chromosomal mapping of a novel cDNA clone encoding human selenium binding protein. (PMID: 9027582) Chang P.W.G. … Fung K. (J. Cell. Biochem. 1997) 2 3 4 65
  5. Progressive loss of selenium-binding protein 1 expression correlates with increasing epithelial proliferation and papillary complexity in ovarian serous borderline tumor and low-grade serous carcinoma. (PMID: 19896693) Zhang C. … Lawrence W.D. (Hum. Pathol. 2010) 3 22 65

Products for SELENBP1 Gene

Sources for SELENBP1 Gene

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