Aliases for SELE Gene
External Ids for SELE Gene
Previous HGNC Symbols for SELE Gene
Previous GeneCards Identifiers for SELE Gene
The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for SELE Gene
SELE (Selectin E) is a Protein Coding gene. Diseases associated with SELE include vasculitis and cutaneous necrotizing vasculitis. Among its related pathways are Hemostasis and Thromboxane A2 receptor signaling. GO annotations related to this gene include transmembrane signaling receptor activity and sialic acid binding. An important paralog of this gene is CSMD3.
UniProtKB/Swiss-Prot for SELE Gene
Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.
Cellular adhesion molecules (CAMs) are a large family of proteins that attach the cytoskeleton and intracellular signalling cascades with the extracellular environment. CAMs have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture, and their dysregulation is common in cancer. The selectins are Ca2+-dependent CAMs that bind fucosylated carbohydrates (e.g. mucins). There are three types of selectins, E-selectin (endothelial), L-selectin (leukocyte) and P-selectin (platelet).