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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SELE Gene

protein-coding GIFtS: 70
GCID: GC01M169691

selectin E

(Previous name: endothelial adhesion molecule 1 )
(Previous symbols: ELAM1, ELAM)

Explore 267 diseases affiliated with
SELE via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Selectin E¹ ²		Leukocyte-Endothelial Cell Adhesion Molecule 2² ³
ELAM1¹ ² ³ ⁵		ELAM-1² ³
CD62E¹ ²		LECAM2² ³
ELAM¹ ²		CD62 Antigen-Like Family Member E² ³
ESEL¹ ²		E-Selectin¹
Endothelial Adhesion Molecule 1¹ ²		Leukocyte Endothelial Cell Adhesion Molecule 2²
Endothelial Leukocyte Adhesion Molecule 1² ³		CD62E Antigen³

External Ids:	HGNC: 10718¹	Entrez Gene: 6401²	Ensembl: ENSG00000007908⁷	OMIM: 131210⁵	UniProtKB: P16581³

Export aliases for SELE gene to outside databases

Previous GC identifers: GC01M167320 GC01M165342 GC01M166181 GC01M166671 GC01M166879 GC01M166423 GC01M167958 GC01M140914

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SELE:

The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for

the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular

lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short

consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin

family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the

endothelium and appear to be involved in the pathogenesis of atherosclerosis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LYAM2_HUMAN, P16581

Function: Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in

cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis

summary for SELE:

Cellular adhesion molecules (CAMs) are a large family of proteins that attach the cytoskeleton and

intracellular signalling cascades with the extracellular environment. CAMs have roles in cell proliferation,

differentiation, motility, trafficking, apoptosis and tissue architecture, and their dysregulation is common

in cancer. The selectins are Ca2+-dependent CAMs that bind fucosylated carbohydrates (e.g. mucins). There

are three types of selectins, E-selectin (endothelial), L-selectin (leukocyte) and P-selectin (platelet).

Gene Wiki entry for SELE (E-selectin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SELE gene promoter:
GR CREB GR-beta STAT3 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SELE promoter sequence

Search SABiosciences Chromatin IP Primers for SELE

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SELE

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22-q25 Ensembl cytogenetic band: 1q24.2 HGNC cytogenetic band: 1q22-q25

SELE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SELE gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M169691: view genomic region (about GC identifiers)

Start:	169,691,781 bp from pter	End:	169,703,220 bp from pter
Size:	11,440 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LYAM2_HUMAN, P16581 (See protein sequence)

Recommended Name: E-selectin precursor

Size: 610 amino acids; 66655 Da

Subunit: Interacts with PSGL1/SELPLG and PODXL2 through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be

required for this interaction

Subcellular location: Membrane; Single-pass type I membrane protein

3 PDB 3D structures from and Proteopedia for SELE:

1ESL (3D)

1G1T (3D)

1KJA (3D)

Secondary accessions: A2RRD6 P16111

Explore the universe of human proteins at neXtProt for SELE: NX_P16581

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P16581

SELE Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000441.2

ENSEMBL proteins:

ENSP00000331736 ENSP00000356751 ENSP00000356749 ENSP00000356750 ENSP00000356748

ENSP00000356755 ENSP00000356756 ENSP00000356754 ENSP00000356753

Human Recombinant Protein Products for SELE:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for SELE (E-Selectin/CD62E)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: SELE OriGene Protein Over-expression Lysate: SELE OriGene Custom Protein Services for SELE
	GenScript Custom Purified and Recombinant Proteins Services for SELE
	Novus Biologicals SELE Proteins Novus Biologicals SELE Lysates
	Sino Biological Recombinant Protein for SELE
	ProSpec Recombinant Protein for SELE
	Uscn Proteins for SELE

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IDA	9290466
GO:0005886	plasma membrane	TAS	2466335
GO:0005901	caveola	IDA	12960351
GO:0005905	coated pit	IDA	18029551
GO:0016020	membrane	--	--

SELE for ontologies About GeneDecksing

SELE Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of SELE
	R&D Systems Antibodies for SELE (E-Selectin/CD62E)
	OriGene Antibodies (see all 2): SELE OriGene Custom Antibody Services for SELE
	GenScript Superior Antibodies for SELE
	Novus Biologicals SELE Antibodies
	Abcam antibodies for SELE
	Uscn Antibodies for SELE
	ThermoFisher Antibodies for SELE

Assay Products for SELE:

	EMD Millipore Kits and Assays for the Analysis of SELE
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for SELE (E-Selectin/CD62E) (see all)
	GenScript Custom Assay Services for SELE
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SELE

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SELE for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR016187 C-type_lectin_fold

IPR002396 Selectin_superfamily

IPR000742 EG-like_dom

IPR018378 C-type_lectin_CS

IPR016186 C-type_lectin-like

Graphical View of Domain Structure for InterPro Entry P16581

ProtoNet protein and cluster: P16581

3 Blocks protein families:

IPB000436 Sushi domain/SCR domain/CCP module

IPB002396 Selectin superfamily complement-binding repeat signature

IPB006210 Type I EGF

UniProtKB/Swiss-Prot: LYAM2_HUMAN, P16581

Similarity: Belongs to the selectin/LECAM family

Similarity: Contains 1 C-type lectin domain

Similarity: Contains 1 EGF-like domain

Similarity: Contains 6 Sushi (CCP/SCR) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: LYAM2_HUMAN, P16581

Function: Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in

cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis

Genatlas biochemistry entry for SELE:

E selectin,leucocyte adhesion molecule,107-115kDa,expressed in endothelial cells,induced by IL1B,TNFA. Mutations of the

gene may be a risk factor in atherosclerosis

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004888	transmembrane signaling receptor activity	IMP	12960351
GO:0005515	protein binding	IPI	18606703
GO:0030246	carbohydrate binding	--	--
GO:0033691	sialic acid binding	IDA	7680663
GO:0043274	phospholipase binding	IDA	12960351

SELE for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for SELE:

Decreased TP53 protein express

Increased G2M DNA content

13 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Sele):

behavior/neurological	cardiovascular system	cellular	growth/size	hematopoietic system
homeostasis/metabolism	immune system	integument	liver/biliary system	mortality/aging
normal	respiratory system	vision/eye

SELE for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for SELE: Sele^tm2Hyn Sele^tm1Alb Sele^tm1Roml Sele^tm1Dmil Sele^tm1Hyn Sele^tm2Alb

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SELE

miRNA Products:		miRTarBase miRNAs that target SELE: hsa-mir-17 (MIRT005712), hsa-mir-1256 (MIRT005716), hsa-mir-31 (MIRT004019), hsa-mir-221 (MIRT005714), hsa-mir-17 (MIRT005711), hsa-mir-155 (MIRT005713), hsa-mir-222 (MIRT005715)

		OriGene 3'-UTR Clone: SELE Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SELE
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate SELE (see all 13):
		hsa-miR-4324 hsa-miR-300 hsa-miR-381 hsa-miR-767-5p hsa-miR-507 hsa-miR-1305 hsa-miR-146a* hsa-miR-377

		SwitchGear 3'UTR luciferase reporter plasmid: SELE 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SELE (see all 7) OriGene shRNA RFP: SELE OriGene siRNA: SELE
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SELE
		Sirion Biotech Custom design and validation of potent shRNA sequences against SELE

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SELE
			Sirion Biotech Customized adenovirus for overexpression of SELE Sirion Biotech Customized adenovirus for potent knockdown of SELE

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SELE (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SELE OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SELE (NM_000450)
		Sino Biological Human cDNA Clone for SELE
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SELE
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELE

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SELE
		Search LifeMap BioReagents cell lines for SELE
		Sirion Biotech Customized stable knockdown cell line services for SELE Sirion Biotech Customized inducible knockdown cell line services for SELE Sirion Biotech Customized stable overexpressing cell line services for SELE Sirion Biotech Customized inducible overexpressing cell line services for SELE

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELE

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell adhesion_Cell-matrix glycoconjugates

Cell adhesion_Cell-matrix glycoconjugates

1.00

Cell adhesion Cell-matrix glycoconjugates

0.97

Development VEGF signaling via VEGFR2 - generic cascades

Development VEGF signaling and activation

0.75

Development_VEGF signaling and activation

0.75

Thromboxane A2 receptor signaling

Thromboxane A2 receptor signaling

1.00

Glucocorticoid receptor regulatory network

Glucocorticoid receptor regulatory network

1.00

ATF-2 transcription factor network

ATF-2 transcription factor network

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for SELE

	Development VEGF signaling and activation
	Cell adhesion Cell-matrix glycoconjugates

2 GeneGo (Thomson Reuters) Pathways for SELE

	Cell adhesion Cell-matrix glycoconjugates
	Development VEGF signaling and activation

3 BioSystems Pathways for SELE

	Thromboxane A2 receptor signaling
	ATF-2 transcription factor network
	Glucocorticoid receptor regulatory network

3 Kegg Pathways (Kegg details for SELE):

	Cell adhesion molecules (CAMs)
	African trypanosomiasis
	Malaria

SELE for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SELE

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/27 Interacting proteins for SELE (P16581^{2, 3} ENSP00000331736⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 27)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTPN11	Q06124²^,³, ENSP00000340944⁴	MINT-8032646 I2D: score=3 STRING: ENSP00000340944
PLCG1	P19174³, ENSP00000244007⁴	I2D: score=2 STRING: ENSP00000244007
SERPING1	P05155³, ENSP00000278407⁴	I2D: score=2 STRING: ENSP00000278407
ACTN2	P35609³, ENSP00000355537⁴	I2D: score=1 STRING: ENSP00000355537
TLN1	Q9Y490³, ENSP00000316029⁴	I2D: score=1 STRING: ENSP00000316029

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002092	positive regulation of receptor internalization	IDA	9312078
GO:0002523	leukocyte migration involved in inflammatory response	TAS	18029551
GO:0002687	positive regulation of leukocyte migration	IEA	--
GO:0006954	inflammatory response	TAS	2466335
GO:0007155	cell adhesion	--	--

SELE for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SELE for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for SELE available from Tocris Bioscience About this table

Compound	Action	CAS #
A 205804	Selective inhibitor of E-selectin and ICAM-1 expression	[251992-66-2]

1 DrugBank Compound for SELE About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
O-Sialic Acid	--	--	target	--	17139284 17016423

10/139 Novoseek chemical compound relationships for SELE gene (see all 139) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
slex	89.9	115	9168056 (6), 8785485 (3), 9861495 (3), 17695536 (2) (see all 71)
sele	83.8	49	11685458 (6), 18094708 (5), 11575218 (3), 10982036 (2) (see all 19)
slea	80.3	18	8785485 (2), 7525435 (2), 8691708 (2), 7532161 (2) (see all 12)
4-f-glcnac	72	2	18056398 (1), 16691194 (1)
esbp	64.7	4	10211877 (2), 19716600 (1)
snh3	61.2	2	11857299 (2)
benzyl-alpha-galnac	61.2	6	9884401 (1), 1284381 (1), 1371678 (1), 7515860 (1)
fc 77	60.9	1	12464366 (1)
polylactosamine	60.1	7	7537499 (1), 8547256 (1), 8547257 (1), 19443639 (1) (see all 5)
n,n,n-trimethylsphingosine	47.4	2	7540991 (2)

Search CenterWatch for drugs/clinical trials and news about SELE / LYAM2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SELE gene:

NM_000450.2

Unigene Cluster for SELE:

Selectin E

Hs.82848 [show with all ESTs]

Unigene Representative Sequence: BC142711

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000333360(uc001ggm.4) ENST00000367777 ENST00000367775 ENST00000367776

ENST00000367774 ENST00000461085 ENST00000367781 ENST00000367782 ENST00000367780

ENST00000367779

miRNA Products:		OriGene 3'-UTR Clone: SELE Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SELE
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate SELE (see all 13):
		hsa-miR-4324 hsa-miR-300 hsa-miR-381 hsa-miR-767-5p hsa-miR-507 hsa-miR-1305 hsa-miR-146a* hsa-miR-377

		SwitchGear 3'UTR luciferase reporter plasmid: SELE 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SELE (see all 7) OriGene shRNA RFP: SELE OriGene siRNA: SELE
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SELE
		Sirion Biotech Custom design and validation of potent shRNA sequences against SELE

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SELE (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SELE OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SELE (NM_000450)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SELE
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELE

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SELE Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SELE
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SELE
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SELE

Additional cDNA sequence:

AK314214.1 AY367062.1 BC131551.1 BC142677.1 BC142711.1 M24736.1 M30640.1

3 DOTS entries:

DT.111795 DT.100004852 DT.97778833

24/41 AceView cDNA sequences (see all 41):

AL047443 AV728800 AA296520 C02556 M30640 AA412545 AA694430 BX116882

NM_000450 AY367062 AL700810 AV651219 M24736 BM955527 BM955528 BM955532

AI150616 BQ003923 AL709413 AV729230 BV183382 BF111109 BM955530 CB051800

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SELE expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTGAAAAA

About this image

SELE expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

Bone marrow-derived adherent progenitor cells (MultiStem) (Adult Stem / Progenitor Cell)

Bone

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

Endothelial progenitor cells (Derivation and purif...)

Endothelial-like cells (Derivation and purif...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SELE Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SELE

SOURCE GeneReport for Unigene cluster: Hs.82848

SABiosciences Expression via Pathway-Focused PCR Arrays including SELE (see all 6):

Extracellular Matrix & Adhesion Molecules in human mouse rat

NFKB Signaling Targets in human mouse rat

Endothelial Cell Biology in human mouse rat

Atherosclerosis in human mouse rat

Inflammatory Response & Autoimmunity in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SELE Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SELE
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SELE
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SELE

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELE

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SELE gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SELE¹	selectin E (endothelial adhesion molecule 1)	58.32(n) 50.54(a)		424402 XM_422246.3 XP_422246.3
lizard (Anolis carolinensis)	Reptilia	--	--		possible ortholog	GL343567.1(230131-410791)
zebrafish (Danio rerio)	Actinopterygii	sele⁶	selectin E	30(a)	1 ↔ 1	20(33994038-34001545)
fruit fly (Drosophila melanogaster)	Insecta	hig⁶	hikaru genki	8(a)	possible ortholog	2R(5115286-5134752)

ENSEMBL Gene Tree for SELE (if available)
TreeFam Gene Tree for SELE (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SELE gene

CSMD1² SEZ6L2² SELP² C4BPA² CR2² SELL² CR1L² CSMD3²

SEZ6² SEZ6L² CSMD2² CR1² CD55² CD46² SVEP1²

2 SIMAP similar genes for SELE using alignment to 5 protein entries: LYAM2_HUMAN (see all proteins):

SELL SELP

SELE for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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UniProtKB/Swiss-Prot: LYAM2_HUMAN, P16581

Polymorphism: A polymorphism in position 149 is associated with a higher risk of coronary artery disease (CAD). A

significantly higher mutation frequency (Arg-149) is observed in patients with angiographically proven severe

atherosclerosis compared with an unselected population (Ser-149)

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs5368^1,2	C,F,O,H	unknown	213291209(-)	`AATTAC/TATGGA`	2	H Y	mis¹ ese³		46		MN EA NS NA CSA WA EU	12052
rs142604792^1,2	C	other	213289475(+)	`CTGAAA/GGCTCT`	2	L F	mis¹		0	--	--	--	--
rs3917447^1,2	C	--	140913660(-)	`CACCCC/GCACAC`	1	--	ds500¹		2		NS	82
rs3917446^1,2	C,F	--	140913661(-)	`ACACCC/TCCACA`	1	--	ds500¹		2		NS	92
rs3917462^1,2	C,F,H	--	140914012(-)	`ACTCCA/GGAAGA`	1	--	ds500¹		9		NS EA NA	632
rs3917442^1,2	C,F,H	--	140914081(-)	`TAAAAC/TTCACT`	1	--	ds500¹		12		NS EA NA WA	1400
rs3917441^1,2	C,F,H	--	140914466(-)	`GCCAAC/GAGTCA`	1	--	ut3¹		15		NS NA EA WA	1322
rs56134395^1,2	C	--	140914981(+)	`TATTAA/GTTCAA`	1	--	ut3¹		0	--	--	--	--
rs5358^1,2	C,F	--	140915021(-)	`GTGGTT/GTCCAC`	1	--	ut3¹ ese³		1		MN	68
rs5357^1,2	C,F,H	--	140915058(-)	`AAGGTT/CTNNNN`	1	--	ut3¹ ese³		20		MN NS NA EA WA	2060

HapMap Linkage Disequilibrium report for SELE (169691781 - 169703220 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SELE: --
Human Gene Mutation Database (HGMD): SELE

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SELE

DNA2.0 Custom Variant and Variant Library Synthesis for SELE

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SELE for disorders           About GeneDecksing

OMIM gene information: 131210
OMIM disorders: 161950  145500
20/267 diseases for SELE (see all 267):    About MalaCards

african tick-bite fever blood pressure regulation qtl heparin-induced thrombocytopenia leukocyte-adhesion deficiency syndrome

atherosclerosis diffuse large b-cell lymphoma disseminated intravascular coagulation arterial occlusive disease

hypersensitivity reaction type ii disease plasmodium vivax malaria age related macular degeneration wegener's granulomatosis

cutaneous necrotizing vasculitis microscopic polyangiitis adult respiratory distress syndrome thromboangiitis obliterans

peripheral arterial occlusive disease critical limb ischemia b-cell lymphomas intermittent claudication

12 diseases from the University of Copenhagen DISEASES database for SELE:

Atherosclerosis Diabetes mellitus Heart disease Vasculitis

Hypertension Hypersensitivity reaction type II disease Dermatitis Arthritis

Connective tissue disease Cancer Cerebrovascular accident Peripheral vascular disease

10/93 Novoseek disease relationships for SELE gene (see all 93) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	80.8	267	15809889 (3), 7512004 (3), 15654200 (3), 1705666 (2) (see all 99)
necrosis	77.9	346	17170373 (4), 11436044 (3), 8556530 (2), 17606807 (2) (see all 99)
atherosclerosis	74.6	73	15803902 (3), 7533025 (2), 8645363 (2), 9102169 (2) (see all 52)
leukocyte adhesion deficiency syndrome	63.4	1	11350525 (1)
tumors	62.7	463	17170373 (4), 11448946 (4), 17456781 (3), 15994950 (3) (see all 99)
vascular diseases	52.1	15	9136912 (3), 14506626 (1), 20129688 (1), 9242960 (1) (see all 12)
cardiovascular diseases	51.8	23	11726042 (2), 16322530 (1), 19171188 (1), 19903755 (1) (see all 20)
colon carcinoma	51.7	35	1372439 (4), 1715924 (3), 9178821 (2), 12684869 (2) (see all 22)
vasculitis	51.2	29	8919225 (3), 7525658 (2), 18927191 (2), 15710215 (1) (see all 20)
atherosclerotic plaque	47.5	7	8640995 (2), 15833768 (1), 12704649 (1), 16076683 (1) (see all 6)

Genetic Association Database (GAD): SELE
Human Genome Epidemiology (HuGE) Navigator: SELE (142 documents)

Export disorders for SELE gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SELE gene, integrated from 9 sources (see all 2289):
(articles sorted by number of sources associating them with SELE)

Utopia: connect your pdf to the dynamic
world of online information

[Association between E-selectin Leu554Phe polymorphism and blood pressure in the Stanislas cohort] (PubMed id 11575218)^{1, 4, 9} Sass C....Visvikis S. (2001)
Relationship between E-selectin L/F554 polymorphism and blood pressure in the Stanislas cohort. (PubMed id 10982036)^{1, 2, 9} Sass C.... Visvikis S. (2000)
E-selectin polymorphism and atherosclerosis: an association study. (PubMed id 7533025)^{1, 2, 9} Wenzel K.... Speer A. (1994)
Association between the Ser128Arg variant of the E-selectin and risk of coronary artery disease in the central China. (PubMed id 16061120)^{1, 4, 9} Li Y....Huang C.X. (2005)
E-selectin genotypes and risk of type 2 diabetes in women. (PubMed id 15833936)^{1, 4, 9} Meigs J.B....Manson J.E. (2005)
Ser128Arg gene polymorphism for E-selectin and severity of atherosclerotic arterial disease. (PubMed id 15179350)^{1, 4, 9} Ghilardi G....Scorza R. (2004)
The Leu554Phe polymorphism in the E-selectin gene is associated with blood pressure in overweight people. (PubMed id 15076188)^{1, 4, 9} Marteau J.B....Visvikis S. (2004)
Genetic influences on blood pressure within the Stanislas Cohort. (PubMed id 15076187)^{1, 4, 9} Sass C....Visvikis S. (2004)
Proinflammatory genetic profiles in subjects with history of ischemic stroke. (PubMed id 15308783)^{1, 4, 9} Flex A....Pola R. (2004)
E-Selectin and restenosis after femoropopliteal angioplasty: prognostic impact of the Ser128Arg genotype and plasma levels. (PubMed id 14691583)^{1, 4, 9} Mlekusch W....Wagner O. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6401	HGNC: 10718	AceView: SELE	Ensembl:ENSG00000007908	euGenes: HUgn6401
ECgene: SELE	Kegg: 6401	H-InvDB: SELE

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SELE	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SELE	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/sele/
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_233

Intellectual Property for SELE gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SELE gene:
Search GeneIP for patents involving SELE

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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Microalbuminuria
Rheumatoid Nodule
Kaposi Sarcoma
nonmetastatic
Hyperinsulinemia
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sepsis
Raynauds Phenomenon
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selectin E

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