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Aliases for SELE Gene

Aliases for SELE Gene

  • Selectin E 2 3
  • ELAM1 3 4 6
  • Leukocyte-Endothelial Cell Adhesion Molecule 2 3 4
  • Endothelial Leukocyte Adhesion Molecule 1 3 4
  • CD62 Antigen-Like Family Member E 3 4
  • Endothelial Adhesion Molecule 1 2 3
  • ELAM-1 3 4
  • LECAM2 3 4
  • Leukocyte Endothelial Cell Adhesion Molecule 2 3
  • CD62E Antigen 4
  • E-Selectin 3
  • CD62E 3
  • ESEL 3
  • ELAM 3

External Ids for SELE Gene

Previous HGNC Symbols for SELE Gene

  • ELAM1
  • ELAM

Previous GeneCards Identifiers for SELE Gene

  • GC01M167320
  • GC01M165342
  • GC01M166181
  • GC01M166671
  • GC01M166879
  • GC01M166423
  • GC01M167958
  • GC01M169691
  • GC01M140914

Summaries for SELE Gene

Entrez Gene Summary for SELE Gene

  • The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for SELE Gene

SELE (Selectin E) is a Protein Coding gene. Diseases associated with SELE include vasculitis and cutaneous necrotizing vasculitis. Among its related pathways are Hemostasis and Thromboxane A2 receptor signaling. GO annotations related to this gene include transmembrane signaling receptor activity and sialic acid binding. An important paralog of this gene is CSMD3.

UniProtKB/Swiss-Prot for SELE Gene

  • Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.

Tocris Summary for SELE Gene

  • Cellular adhesion molecules (CAMs) are a large family of proteins that attach the cytoskeleton and intracellular signalling cascades with the extracellular environment. CAMs have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture, and their dysregulation is common in cancer. The selectins are Ca2+-dependent CAMs that bind fucosylated carbohydrates (e.g. mucins). There are three types of selectins, E-selectin (endothelial), L-selectin (leukocyte) and P-selectin (platelet).

Gene Wiki entry for SELE Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELE Gene

Genomics for SELE Gene

Regulatory Elements for SELE Gene

Genomic Location for SELE Gene

169,722,640 bp from pter
169,764,705 bp from pter
42,066 bases
Minus strand

Genomic View for SELE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SELE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELE Gene

Proteins for SELE Gene

  • Protein details for SELE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A2RRD6
    • P16111

    Protein attributes for SELE Gene

    610 amino acids
    Molecular mass:
    66655 Da
    Quaternary structure:
    • Interacts with PSGL1/SELPLG and PODXL2 through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction.

    Three dimensional structures from OCA and Proteopedia for SELE Gene

neXtProt entry for SELE Gene

Proteomics data for SELE Gene at MOPED

Post-translational modifications for SELE Gene

  • Glycosylation at Asn25, Asn145, Asn160, Asn179, Asn199, Asn203, Asn265, Asn312, Asn332, Asn503, and Asn527
  • Modification sites at PhosphoSitePlus

Other Protein References for SELE Gene

Antibody Products

  • R&D Systems Antibodies for SELE (E-Selectin/CD62E)

No data available for DME Specific Peptides for SELE Gene

Domains for SELE Gene

Gene Families for SELE Gene

Suggested Antigen Peptide Sequences for SELE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C-type lectin domain.
  • Belongs to the selectin/LECAM family.
  • Contains 1 C-type lectin domain.
  • Contains 1 EGF-like domain.
  • Contains 6 Sushi (CCP/SCR) domains.
  • Belongs to the selectin/LECAM family.
genes like me logo Genes that share domains with SELE: view

Function for SELE Gene

Molecular function for SELE Gene

GENATLAS Biochemistry:
E selectin,leucocyte adhesion molecule,107-115kDa,expressed in endothelial cells,induced by IL1B,TNFA. Mutations of the gene may be a risk factor in atherosclerosis
UniProtKB/Swiss-Prot Function:
Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.

Gene Ontology (GO) - Molecular Function for SELE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IMP 12960351
GO:0005515 protein binding IPI 18606703
GO:0030246 carbohydrate binding --
GO:0033691 sialic acid binding IDA 7680663
GO:0043274 phospholipase binding IDA 12960351
genes like me logo Genes that share ontologies with SELE: view
genes like me logo Genes that share phenotypes with SELE: view

Animal Models for SELE Gene

MGI Knock Outs for SELE:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SELE

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SELE Gene

Localization for SELE Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELE Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for SELE Gene COMPARTMENTS Subcellular localization image for SELE gene
Compartment Confidence
cytoskeleton 4
extracellular 4
plasma membrane 4
nucleus 3
golgi apparatus 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SELE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 9290466
GO:0005886 plasma membrane TAS --
GO:0005901 caveola IDA 12960351
GO:0005905 coated pit IDA 18029551
GO:0016020 membrane --
genes like me logo Genes that share ontologies with SELE: view

Pathways for SELE Gene

genes like me logo Genes that share pathways with SELE: view

PCR Array Products

Gene Ontology (GO) - Biological Process for SELE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002092 positive regulation of receptor internalization IDA 9312078
GO:0002523 leukocyte migration involved in inflammatory response TAS 18029551
GO:0002687 positive regulation of leukocyte migration IEA --
GO:0006954 inflammatory response TAS 2466335
GO:0007155 cell adhesion --
genes like me logo Genes that share ontologies with SELE: view

Compounds for SELE Gene

(2) Drugbank Compounds for SELE Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • (+-)-1-(Carbazol-4-yloxy)-3-((2-(O-methoxyphenoxy)ethyl)amino)-2-propanol
72956-09-3 2585 Target inhibitor approved, investigational
O-Sialic Acid
36690637 Target experimental

(5) Tocris Compounds for SELE Gene

Compound Action Cas Number
A 286982 Potent inhibitor of the LFA-1/ICAM-1 interaction [280749-17-9]
Ac2-26 Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation [151988-33-9]
Echistatin, alpha1 isoform alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor [154303-05-6]
Heparin sodium salt Anticoagulant [9041-08-1]
RGDS peptide Integrin binding sequence; inhibits integrin receptor function [91037-65-9]

(139) Novoseek inferred chemical compound relationships for SELE Gene

Compound -log(P) Hits PubMed IDs
slex 89.9 91
sele 83.8 35
slea 80.3 16
4-f-glcnac 72 2
esbp 64.7 3
genes like me logo Genes that share compounds with SELE: view

Transcripts for SELE Gene

Unigene Clusters for SELE Gene

Selectin E:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SELE

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELE Gene

No ASD Table

Relevant External Links for SELE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SELE Gene

mRNA expression in normal human tissues for SELE Gene

mRNA differential expression in normal tissues according to GTEx for SELE Gene

This gene is overexpressed in Fallopian Tube (8.9) and Adipose - Visceral (Omentum) (6.5).

SOURCE GeneReport for Unigene cluster for SELE Gene Hs.82848

genes like me logo Genes that share expressions with SELE: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for SELE Gene

Orthologs for SELE Gene

This gene was present in the common ancestor of animals.

Orthologs for SELE Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia SELE 35
  • 81.2 (n)
  • 75.59 (a)
  • 78 (a)
(Mus musculus)
Mammalia Sele 35
  • 77.74 (n)
  • 73.36 (a)
Sele 16
Sele 36
  • 72 (a)
(Pan troglodytes)
Mammalia SELE 35
  • 99.34 (n)
  • 99.18 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Sele 35
  • 74.01 (n)
  • 71.19 (a)
(Bos Taurus)
Mammalia SELE 36
  • 61 (a)
(Monodelphis domestica)
Mammalia SELE 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia SELE 36
  • 58 (a)
(Gallus gallus)
Aves SELE 35
  • 57.98 (n)
  • 50.21 (a)
  • 51 (a)
(Danio rerio)
Actinopterygii selp 36
  • 28 (a)
fruit fly
(Drosophila melanogaster)
Insecta hig 36
  • 10 (a)
(Caenorhabditis elegans)
Secernentea T07H6.4 36
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 7 (a)
-- 36
  • 9 (a)
-- 36
  • 12 (a)
-- 36
  • 7 (a)
-- 36
  • 10 (a)
CSA.10017 36
  • 21 (a)
CSA.10029 36
  • 8 (a)
Species with no ortholog for SELE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SELE Gene

Gene Tree for SELE (if available)
Gene Tree for SELE (if available)

Paralogs for SELE Gene

Paralogs for SELE Gene

(2) SIMAP similar genes for SELE Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SELE: view

Variants for SELE Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SELE Gene

A polymorphism in position 149 is associated with a higher risk of coronary artery disease (CAD). A significantly higher mutation frequency (Arg-149) is observed in patients with angiographically proven severe atherosclerosis compared with an unselected population (Ser-149).

Sequence variations from dbSNP and Humsavar for SELE Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4786 -- 169,722,991(-) GCAAC(A/G)ACAAA utr-variant-3-prime
rs5353 -- 169,733,833(+) TTCAT(C/T)ATTTA intron-variant
rs5354 -- 169,733,767(-) TAGTG(G/T)CCTTT intron-variant
rs5355 - 169,726,729(-) CATTT(C/T)TCCTC reference, missense
rs5356 -- 169,725,777(-) TCAGA(C/T)GGAAG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for SELE Gene

Variant ID Type Subtype PubMed ID
nsv872541 CNV Loss 21882294

Relevant External Links for SELE Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for SELE Gene

(1) OMIM Diseases for SELE Gene (131210)

(93) Novoseek inferred disease relationships for SELE Gene

Disease -log(P) Hits PubMed IDs
inflammation 80.8 121
necrosis 77.9 115
atherosclerosis 74.6 66
leukocyte adhesion deficiency syndrome 63.4 1
tumors 62.7 156

Relevant External Links for SELE

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SELE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SELE Gene

Publications for SELE Gene

  1. ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex. (PMID: 1701274) Phillips M.L. … Paulson J.C. (Science 1990) 3 4 23
  2. E-selectin polymorphism and atherosclerosis: an association study. (PMID: 7533025) Wenzel K. … Speer A. (Hum. Mol. Genet. 1994) 3 4 23
  3. Relationship between E-selectin L/F554 polymorphism and blood pressure in the Stanislas cohort. (PMID: 10982036) Sass C. … Visvikis S. (Hum. Genet. 2000) 3 4 23
  4. DNA polymorphisms in adhesion molecule genes -- a new risk factor for early atherosclerosis. (PMID: 8557254) Wenzel K. … Speer A. (Hum. Genet. 1996) 3 4 23
  5. Gender- and age-dependent relationships between the E-selectin S128R polymorphism and coronary artery calcification. (PMID: 11466561) Ellsworth D.L. … Peyser P.A. (J. Mol. Med. 2001) 3 23 48

Products for SELE Gene

  • Addgene plasmids for SELE

Sources for SELE Gene

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