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SELE Gene

protein-coding   GIFtS: 70
GCID: GC01M169691

Selectin E

(Previous name: endothelial adhesion molecule 1)
(Previous symbols: ELAM1, ELAM)
  See SELE-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Selectin E1 2     LECAM22 3
ELAM11 2 3 5     CD62 Antigen-Like Family Member E2 3
ELAM1 2     CD62E2
Endothelial Adhesion Molecule 11 2     E-selectin2
Endothelial Leukocyte Adhesion Molecule 12 3     ESEL2
Leukocyte-Endothelial Cell Adhesion Molecule 22 3     Leukocyte Endothelial Cell Adhesion Molecule 22
ELAM-12 3     CD62E Antigen3

External Ids:    HGNC: 107181   Entrez Gene: 64012   Ensembl: ENSG000000079087   OMIM: 1312105   UniProtKB: P165813   

Export aliases for SELE gene to outside databases

Previous GC identifers: GC01M167320 GC01M165342 GC01M166181 GC01M166671 GC01M166879 GC01M166423 GC01M167958 GC01M140914


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SELE Gene:
The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be
responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells
to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains
followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are
part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between
leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. (provided by
RefSeq, Jul 2008)

GeneCards Summary for SELE Gene:
SELE (selectin E) is a protein-coding gene. Diseases associated with SELE include vasculitis, and leukostasis. GO annotations related to this gene include transmembrane signaling receptor activity and sialic acid binding. An important paralog of this gene is CSMD1.

UniProtKB/Swiss-Prot: LYAM2_HUMAN, P16581
Function: Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils
in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary
morphogenesis

summary for SELE Gene:
Cellular adhesion molecules (CAMs) are a large family of proteins that attach the cytoskeleton and
intracellular signalling cascades with the extracellular environment. CAMs have roles in cell proliferation,
differentiation, motility, trafficking, apoptosis and tissue architecture, and their dysregulation is common
in cancer. The selectins are Ca2+-dependent CAMs that bind fucosylated carbohydrates (e.g. mucins). There
are three types of selectins, E-selectin (endothelial), L-selectin (leukocyte) and P-selectin (platelet).

Gene Wiki entry for SELE (E-selectin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the SELE gene promoter:
         GR   CREB   GR-beta   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSELE promoter sequence
   Search Chromatin IP Primers for SELE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SELE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22-q25   Ensembl cytogenetic band:  1q24.2   HGNC cytogenetic band: 1q22-q25

SELE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SELE gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M169691:  view genomic region     (about GC identifiers)

Start:
169,691,781 bp from pter      End:
169,733,846 bp from pter
Size:
42,066 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LYAM2_HUMAN, P16581 (See protein sequence)
Recommended Name: E-selectin precursor  
Size: 610 amino acids; 66655 Da
Subunit: Interacts with PSGL1/SELPLG and PODXL2 through the sialyl Lewis X epitope. PSGL1 sulfation appears not to
be required for this interaction
3 PDB 3D structures from and Proteopedia for SELE:
1ESL (3D)        1G1T (3D)        1KJA (3D)    
Secondary accessions: A2RRD6 P16111

Explore the universe of human proteins at neXtProt for SELE: NX_P16581

Explore proteomics data for SELE at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn25, Asn145, Asn160, Asn179, Asn199, Asn203, Asn265, Asn312, Asn332, Asn503,
                                 Asn527

  • See SELE Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000441.2  
    ENSEMBL proteins: 
     ENSP00000356749   ENSP00000356751   ENSP00000356750   ENSP00000331736   ENSP00000356748  
     ENSP00000476784   ENSP00000356755   ENSP00000356756   ENSP00000356754   ENSP00000356753  
    Reactome Protein details: P16581

    SELE Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for SELE (E-Selectin/CD62E)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SELE
    OriGene Protein Over-expression Lysate for SELE
    OriGene MassSpec for SELE
    OriGene Custom Protein Services for SELE
    GenScript Custom Purified and Recombinant Proteins Services for SELE
    Novus Biologicals SELE Proteins
    Novus Biologicals SELE Lysates
    Sino Biological Recombinant Protein for SELE
    Sino Biological Cell Lysate for SELE
    ProSpec Recombinant Protein for SELE
    Cloud-Clone Corp. Proteins for SELE

     
    Search eBioscience for Proteins for SELE 

    SELE Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SELE
    R&D Systems Antibodies for SELE (E-Selectin/CD62E)
    OriGene Antibodies for SELE
    OriGene Custom Antibody Services for SELE
    Novus Biologicals SELE Antibodies
    Abcam antibodies for SELE
    Cloud-Clone Corp. Antibodies for SELE
    ThermoFisher Antibodies for SELE
    LSBio Antibodies in human, mouse, rat for SELE

    SELE Assay Products:

    EMD Millipore Kits and Assays for the Analysis of SELE
    OriGene Custom Assay Services for SELE
    R&D Systems ELISAs for SELE (E-Selectin/CD62E)         (see all)
    GenScript Custom Assay Services for SELE
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SELE
    Cloud-Clone Corp. CLIAs for SELE
    eBioscience ELISAs for SELE: (see all 5
                        Human sE-selectin Platinum ELISA 96 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    Selected InterPro protein domains (see all 8):
     IPR002396 Selectin_superfamily
     IPR000742 EG-like_dom
     IPR000436 Sushi_SCR_CCP
     IPR016187 C-type_lectin_fold
     IPR018378 C-type_lectin_CS

    Graphical View of Domain Structure for InterPro Entry P16581

    ProtoNet protein and cluster: P16581

    3 Blocks protein domains:
    IPB000436 Sushi domain/SCR domain/CCP module
    IPB002396 Selectin superfamily complement-binding repeat signature
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: LYAM2_HUMAN, P16581
    Similarity: Belongs to the selectin/LECAM family
    Similarity: Contains 1 C-type lectin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 6 Sushi (CCP/SCR) domains


    Find genes that share domains with SELE           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LYAM2_HUMAN, P16581
    Function: Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils
    in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary
    morphogenesis

         Genatlas biochemistry entry for SELE:
    E selectin,leucocyte adhesion molecule,107-115kDa,expressed in endothelial cells,induced by IL1B,TNFA. Mutations
    of the gene may be a risk factor in atherosclerosis

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity IMP12960351
    GO:0005515protein binding IPI18606703
    GO:0030246carbohydrate binding ----
    GO:0033691sialic acid binding IDA7680663
    GO:0043274phospholipase binding IDA12960351
         
    Find genes that share ontologies with SELE           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SELE:
     Decreased TP53 protein express  Increased G2M DNA content 

         13 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Sele):
     behavior/neurological  cardiovascular system  cellular  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     normal  respiratory system  vision/eye 

    Find genes that share phenotypes with SELE           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SELE: Seletm2Hyn Seletm1Alb Seletm1Roml Seletm1Dmil Seletm1Hyn Seletm2Alb

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SELE
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SELE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SELE
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SELE

    miRNA
    Products:
        
    miRTarBase miRNAs that target SELE:
    hsa-mir-17-3p (MIRT005712), hsa-mir-1256 (MIRT005716), hsa-mir-31-5p (MIRT004019), hsa-mir-221-3p (MIRT005714), hsa-mir-17-5p (MIRT005711), hsa-mir-155-5p (MIRT005713), hsa-mir-222-3p (MIRT005715)

    Block miRNA regulation of human, mouse, rat SELE using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SELE (see all 13):
    hsa-miR-4324 hsa-miR-300 hsa-miR-381 hsa-miR-767-5p hsa-miR-507 hsa-miR-1305 hsa-miR-146a* hsa-miR-377
    SwitchGear 3'UTR luciferase reporter plasmidSELE 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SELE
    Predesigned siRNA for gene silencing in human, mouse, rat SELE

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SELE

    Clone
    Products:
         
    OriGene clones in human, mouse for SELE (see all 7)
    OriGene ORF clones in mouse, rat for SELE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SELE (NM_000450)
    Sino Biological Human cDNA Clone for SELE
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SELE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELE
    Addgene plasmids for SELE 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SELE
    Browse ESI BIO Cell Lines and PureStem Progenitors for SELE 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELE


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LYAM2_HUMAN, P16581: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    extracellular4
    plasma membrane4
    nucleus3
    golgi apparatus1
    lysosome1
    peroxisome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA9290466
    GO:0005886plasma membrane TAS--
    GO:0005901caveola IDA12960351
    GO:0005905coated pit IDA18029551
    GO:0016020membrane ----

    Find genes that share ontologies with SELE           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SELE About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Development VEGF signaling and activation
    Development VEGF signaling and activation0.75
    2Hemostasis
    Hemostasis0.43
    3TNF signaling pathway
    TNF signaling pathway
    4Thromboxane A2 receptor signaling
    Thromboxane A2 receptor signaling
    5Malaria
    Malaria


    Find genes that share SuperPaths with SELE           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for SELE
        Cell adhesion Cell-matrix glycoconjugates
    Development VEGF signaling and activation

    3 BioSystems Pathways for SELE
        ATF-2 transcription factor network
    Thromboxane A2 receptor signaling
    Glucocorticoid receptor regulatory network


    1 Reactome Pathway for SELE
        Cell surface interactions at the vascular wall


    4 Kegg Pathways  (Kegg details for SELE):
        Cell adhesion molecules (CAMs)
    TNF signaling pathway
    African trypanosomiasis
    Malaria

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SELE (see all 6): 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Atherosclerosis in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SELE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SELE (P165812, 3 ENSP000003317364) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN11Q061242, 3, ENSP000003409444MINT-8032646 I2D: score=3 STRING: ENSP00000340944
    PLCG1P191743, ENSP000002440074I2D: score=2 STRING: ENSP00000244007
    SERPING1P051553, ENSP000002784074I2D: score=2 STRING: ENSP00000278407
    ACTN2P356093, ENSP000003555374I2D: score=1 STRING: ENSP00000355537
    TLN1Q9Y4903, ENSP000003160294I2D: score=1 STRING: ENSP00000316029
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002092positive regulation of receptor internalization IDA9312078
    GO:0002523leukocyte migration involved in inflammatory response TAS18029551
    GO:0002687positive regulation of leukocyte migration IEA--
    GO:0006954inflammatory response TAS2466335
    GO:0007155cell adhesion ----

    Find genes that share ontologies with SELE           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for SELE available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ThiolutinBacterial RNA polymerase inhibitor[87-11-6]
    Heparin sodium saltAnticoagulant[9041-08-1]
    Echistatin, alpha1 isoform alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor[154303-05-6]
    RGDS peptideIntegrin binding sequence; inhibits integrin receptor function[91037-65-9]
    Ac2-26Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation[151988-33-9]

    1 DrugBank Compound for SELE    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    O-Sialic Acid-- --target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for SELE gene (see all 139)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    slex 89.9 115 9168056 (6), 8785485 (3), 9861495 (3), 17695536 (2) (see all 71)
    sele 83.8 49 11685458 (6), 18094708 (5), 11575218 (3), 10982036 (2) (see all 19)
    slea 80.3 18 8785485 (2), 7525435 (2), 8691708 (2), 7532161 (2) (see all 12)
    4-f-glcnac 72 2 18056398 (1), 16691194 (1)
    esbp 64.7 4 10211877 (2), 19716600 (1)
    snh3 61.2 2 11857299 (2)
    benzyl-alpha-galnac 61.2 6 9884401 (1), 1284381 (1), 1371678 (1), 7515860 (1)
    fc 77 60.9 1 12464366 (1)
    polylactosamine 60.1 7 7537499 (1), 8547256 (1), 8547257 (1), 19443639 (1) (see all 5)
    n,n,n-trimethylsphingosine 47.4 2 7540991 (2)



    Find genes that share compounds with SELE           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SELE gene: 
    NM_000450.2  

    Unigene Cluster for SELE:

    Selectin E
    Hs.82848  [show with all ESTs]
    Unigene Representative Sequence: BC142711
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367775 ENST00000367777 ENST00000367776 ENST00000333360(uc001ggm.4)
    ENST00000367774 ENST00000461085 ENST00000609271 ENST00000367781 ENST00000367782
    ENST00000367780 ENST00000367779
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SELE using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SELE (see all 13):
    hsa-miR-4324 hsa-miR-300 hsa-miR-381 hsa-miR-767-5p hsa-miR-507 hsa-miR-1305 hsa-miR-146a* hsa-miR-377
    SwitchGear 3'UTR luciferase reporter plasmidSELE 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SELE
    Predesigned siRNA for gene silencing in human, mouse, rat SELE
    Clone
    Products:
         
    OriGene clones in human, mouse for SELE (see all 7)
    OriGene ORF clones in mouse, rat for SELE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SELE (NM_000450)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SELE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SELE
    Addgene plasmids for SELE 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SELE
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SELE
      QuantiTect SYBR Green Assays in human, mouse, rat SELE
      QuantiFast Probe-based Assays in human, mouse, rat SELE

    Additional mRNA sequence: 

    AK314214.1 AY367062.1 BC131551.1 BC142677.1 BC142711.1 M24736.1 M30640.1 

    3 DOTS entries:

    DT.111795  DT.100004852  DT.97778833 

    Selected AceView cDNA sequences (see all 41):

    AA296520 AV728800 AA694430 AL047443 C02556 AA412545 M30640 M24736 
    BV183382 BQ003923 BM955530 BX116882 AL709413 AV729230 AV651219 BM955532 
    AL700810 CB051800 BM955527 AY367062 AI150616 BF111109 BM955528 NM_000450 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SELE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTGAAAAA
    SELE Expression
    About this image


    SELE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow
             Bone marrow-derived adherent progenitor cells (MultiStem)
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             UEA-1 isolated cells
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced cells
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             Stromal Cells Subcutaneous White Adipose
             Adipose-derived stromal cells
     
     Mesenchymal Stem Cells
             Adipose-derived stromal cells
    SELE Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SELE Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.82848
        Pathway & Disease-focused RT2 Profiler PCR Arrays including SELE (see all 6): 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Atherosclerosis in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SELE
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SELE
    QuantiTect SYBR Green Assays in human, mouse, rat SELE
    QuantiFast Probe-based Assays in human, mouse, rat SELE
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SELE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for SELE gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sele1 , 5 selectin, endothelial cell1, 5 77.74(n)1
    73.36(a)1
      1 (71.35 cM)5
    203391  NM_011345.21  NP_035475.11 
     1640482345 
    chicken
    (Gallus gallus)
    Aves SELE1 selectin E (endothelial adhesion molecule 1) 57.98(n)
    50.21(a)
      424402  XM_422246.4  XP_422246.4 
    zebrafish
    (Danio rerio)
    Actinopterygii selp6
    selectin P
    28(a)
    1 → many
    20(33973250-33984423) ENSDARG00000042138
    fruit fly
    (Drosophila melanogaster)
    Insecta hig6
    hikaru genki
    10(a)
    1 → many
    2R(5115286-5134752)
    worm
    (Caenorhabditis elegans)
    Secernentea T07H6.46
    Protein T07H6.4 (T07H6.4) mRNA, complete cds
    12(a)
    many ↔ many
    X(6281917-6286172) WBGene00020331


    ENSEMBL Gene Tree for SELE (if available)
    TreeFam Gene Tree for SELE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SELE gene
    CSMD12  SELP2  C4BPA2  CR22  SELL2  CSMD32  CR1L2  APOH2  
    CSMD22  CD462  CD552  CR12  SVEP12  
    2 SIMAP similar genes for SELE using alignment to 6 protein entries:     LYAM2_HUMAN (see all proteins):
    SELL    SELP

    Find genes that share paralogs with SELE           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    LYAM2_HUMAN, P16581: A polymorphism in position 149 is associated with a higher risk of coronary artery disease (CAD). A
    significantly higher mutation frequency (Arg-149) is observed in patients with angiographically proven severe
    atherosclerosis compared with an unselected population (Ser-149)


    Selected SNPs for SELE (see all 434)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1426047921,2
    Cuntested1176251134(+) CTGAAA/GGCTCT 2 L F mis10--------
    rs53681,2,,4
    C,F,O,Hunknown1176249400(-) AATTAC/TATGGA 2 H Y mis1 ese346Minor allele frequency- T:0.11MN EA NS NA CSA WA EU 12052
    rs39174451,2
    C,F--169691314(-) ACCCCC/-ACACC 1 -- ds50013Minor allele frequency- -:0.20NS CSA 94
    rs2009456301,2
    C--169694529(+) AAAAA-/AGTAAA 1 -- int10--------
    rs606324941,2
    C--169699839(+) TTTTT-/TAGTTT 1 -- int10--------
    rs39174161,2
    C,F--169700078(-) ATTTG-/T/TGT 
            
    TGTGG
    2 -- int1 cds12NS 94
    rs601734621,2
    C--169700241(+) CTGTG-/TGGCTAC 1 -- int10--------
    rs39173881,2
    C,F--169704662(-) caagcG/Aattct 1 -- us2k12Minor allele frequency- A:0.04NS 82
    rs576631661,2
    --176243741(+) GTGTGC/TGTGTG 1 -- ds50015Minor allele frequency- T:0.15NA CSA WA EA 362
    rs1179376901,2
    F--176243742(+) TGTGCG/ATGTGT 1 -- ds50011Minor allele frequency- A:0.07EA 120

    HapMap Linkage Disequilibrium report for SELE (169691781 - 169733846 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SELE:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv872541CNV Loss21882294

    Human Gene Mutation Database (HGMD): SELE
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SELE
    DNA2.0 Custom Variant and Variant Library Synthesis for SELE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 131210   
    OMIM disorders: 145500  
    Selected diseases for SELE (see all 27):    
    About MalaCards
    vasculitis    leukostasis    cutaneous necrotizing vasculitis    rheumatoid vasculitis
    ovarian cystadenoma    lymphocytic vasculitis    thromboangiitis obliterans    african tick-bite fever
    leukocyte adhesion deficiency    pustulosis palmaris et plantaris    amebiasis    fascioliasis
    cystadenoma    cardiovascular disease risk factor    pancreas adenocarcinoma    atherosclerosis
    plasmodium vivax malaria    lumbar disc disease    vascular disease    wegener's granulomatosis

    12 diseases from the University of Copenhagen DISEASES database for SELE:
    Atherosclerosis     Diabetes mellitus     Heart disease     Vasculitis
    Hypertension     Hypersensitivity reaction type II disease     Dermatitis     Arthritis
    Connective tissue disease     Cancer     Cerebrovascular accident     Peripheral vascular disease

    Find genes that share disorders with SELE           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SELE gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 80.8 267 15809889 (3), 7512004 (3), 15654200 (3), 1705666 (2) (see all 99)
    necrosis 77.9 346 17170373 (4), 11436044 (3), 8556530 (2), 17606807 (2) (see all 99)
    atherosclerosis 74.6 73 15803902 (3), 7533025 (2), 8645363 (2), 9102169 (2) (see all 52)
    leukocyte adhesion deficiency syndrome 63.4 1 11350525 (1)
    tumors 62.7 463 17170373 (4), 11448946 (4), 17456781 (3), 15994950 (3) (see all 99)
    vascular diseases 52.1 15 9136912 (3), 14506626 (1), 20129688 (1), 9242960 (1) (see all 12)
    cardiovascular diseases 51.8 23 11726042 (2), 16322530 (1), 19171188 (1), 19903755 (1) (see all 20)
    colon carcinoma 51.7 35 1372439 (4), 1715924 (3), 9178821 (2), 12684869 (2) (see all 22)
    vasculitis 51.2 29 8919225 (3), 7525658 (2), 18927191 (2), 15710215 (1) (see all 20)
    atherosclerotic plaque 47.5 7 8640995 (2), 15833768 (1), 12704649 (1), 16076683 (1) (see all 6)

    Genetic Association Database (GAD): SELE
    Human Genome Epidemiology (HuGE) Navigator: SELE (142 documents)

    Export disorders for SELE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SELE gene, integrated from 10 sources (see all 2315):
    (articles sorted by number of sources associating them with SELE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The common variants of E-selectin gene in Graves' disease. (PubMed id 18094708)1, 4, 9 Chen H....Ning G. (Genes Immun. 2008)
    2. Polymorphism in L-selectin, E-selectin and ICAM-1 genes in Asian Indian pediatric patients with celiac disease. (PubMed id 16916660)1, 4, 9 Kaur G....Mehra N.K. (Hum. Immunol. 2006)
    3. [Association between E-selectin Leu554Phe polymorphism and blood pressure in the Stanislas cohort]. (PubMed id 11575218)1, 4, 9 Sass C....Visvikis S. (Arch Mal Coeur Vaiss 2001)
    4. E-selectin and L-selectin polymorphisms in patients with periodontitis. (PubMed id 18973547)1, 4, 9 Houshmand B....Gholami L. (J. Periodont. Res. 2009)
    5. Relationship between E-selectin L/F554 polymorphism and blood pressure in the Stanislas cohort. (PubMed id 10982036)1, 2, 9 Sass C.... Visvikis S. (Hum. Genet. 2000)
    6. E-selectin polymorphism and atherosclerosis: an association study. (PubMed id 7533025)1, 2, 9 Wenzel K.... Speer A. (Hum. Mol. Genet. 1994)
    7. Role of ICAM-1 and E-selectin gene polymorphisms in pathogenesis of PAOD in Egyptian patients. (PubMed id 20191078)1, 4, 9 Shaker O....Ay-El Deen M. (Vasc Health Risk Manag 2010)
    8. Genetic predisposition of E-selectin gene (S128R) polymorphism in patients with coronary artery disease (CAD). (PubMed id 19942746)1, 4, 9 Tripathi R....Agarwal S. (Indian J. Med. Res. 2009)
    9. Polymorphism in ICAM-1, PECAM-1, E-selectin, and L-selectin genes in Tunisian patients with inflammatory bowel disease. (PubMed id 19212205)1, 4, 9 Khazen D....Ayed K. (amp 2009)
    10. Role of S128R polymorphism of E-selectin in colon metastasis formation. (PubMed id 17372905)1, 4, 9 Alessandro R....De Leo G. (Int. J. Cancer 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6401 HGNC: 10718 AceView: SELE Ensembl:ENSG00000007908 euGenes: HUgn6401
    ECgene: SELE Kegg: 6401 H-InvDB: SELE

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SELE Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SELE Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/sele/
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_233

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SELE gene:
    Search GeneIP for patents involving SELE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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