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Aliases for SEL1L3 Gene

Aliases for SEL1L3 Gene

  • SEL1L Family Member 3 2 3 5
  • Suppressor Of Lin-12-Like Protein 3 3 4
  • Sel-1L3 3 4
  • Sel-1 Suppressor Of Lin-12-Like 3 (C. Elegans) 2
  • Sel-1 Suppressor Of Lin-12-Like 3 3
  • Protein Sel-1 Homolog 3 3
  • KIAA0746 Protein 2
  • KIAA0746 4

External Ids for SEL1L3 Gene

Previous GeneCards Identifiers for SEL1L3 Gene

  • GC04M025358
  • GC04M025749
  • GC04M025087
  • GC04M025756
  • GC04M025763
  • GC04M025766
  • GC04M025770

Summaries for SEL1L3 Gene

GeneCards Summary for SEL1L3 Gene

SEL1L3 (SEL1L Family Member 3) is a Protein Coding gene. An important paralog of this gene is SEL1L.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEL1L3 Gene

Genomics for SEL1L3 Gene

Regulatory Elements for SEL1L3 Gene

Enhancers for SEL1L3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F025912 1.1 ENCODE 16.8 -50.5 -50519 3.0 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SMIM20 SEL1L3 ANAPC4 PI4K2B SEPSECS LOC105374538 PIR49686
GH04F025873 1.1 FANTOM5 ENCODE 11.5 -11.9 -11856 3.4 PKNOX1 MAX BMI1 EED ZNF207 ETV6 CREM CHD2 RNF2 MTA2 SEL1L3 ENSG00000251009 GC04M025896
GH04F025908 1 Ensembl ENCODE 11.3 -44.8 -44839 1.0 SOX13 TFAP4 SAP130 JUN ARID4B ZNF140 ZNF644 POLR2A RBAK FOS SMIM20 ANAPC4 SEL1L3 LOC105374538 GC04M025896
GH04F025879 0.8 Ensembl 11.6 -15.5 -15541 1.0 BCOR PKNOX1 ZMYM3 CEBPG ZFHX2 CREM EGR2 SMARCA5 MTA2 TRIM22 SEL1L3 ENSG00000251009 GC04M025896
GH04F025919 1.2 Ensembl ENCODE 5.7 -56.1 -56068 1.2 TBP PKNOX1 ARID4B THRB RARA FOS CREM THAP11 CEBPB ZEB2 SMIM20 SEL1L3 PIR49686 LOC105374538
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SEL1L3 on UCSC Golden Path with GeneCards custom track

Promoters for SEL1L3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001238393 1160 2801 PKNOX1 SP3 KAT8 CREB3 MAFF SMARCA4 GLIS1 PBX2 STAT3 KDM1A

Genomic Location for SEL1L3 Gene

Chromosome:
4
Start:
25,721,867 bp from pter
End:
25,863,760 bp from pter
Size:
141,894 bases
Orientation:
Minus strand

Genomic View for SEL1L3 Gene

Genes around SEL1L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEL1L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEL1L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEL1L3 Gene

Proteins for SEL1L3 Gene

  • Protein details for SEL1L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68CR1-SE1L3_HUMAN
    Recommended name:
    Protein sel-1 homolog 3
    Protein Accession:
    Q68CR1
    Secondary Accessions:
    • A0PJH6
    • A8K0X2
    • O94847
    • Q6P999
    • Q96G59

    Protein attributes for SEL1L3 Gene

    Size:
    1132 amino acids
    Molecular mass:
    128567 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH29422.1; Type=Miscellaneous discrepancy; Note=Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH60867.1; Type=Frameshift; Positions=65; Evidence={ECO:0000305};

    Alternative splice isoforms for SEL1L3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEL1L3 Gene

Post-translational modifications for SEL1L3 Gene

  • Glycosylation at Asn 201, Asn 382, Asn 527, and Asn 937
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SEL1L3 Gene

Domains & Families for SEL1L3 Gene

Protein Domains for SEL1L3 Gene

Suggested Antigen Peptide Sequences for SEL1L3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q68CR1

UniProtKB/Swiss-Prot:

SE1L3_HUMAN :
  • Contains 8 Sel1-like repeats.
Similarity:
  • Contains 8 Sel1-like repeats.
genes like me logo Genes that share domains with SEL1L3: view

No data available for Gene Families for SEL1L3 Gene

Function for SEL1L3 Gene

Phenotypes for SEL1L3 Gene

GenomeRNAi human phenotypes for SEL1L3:
genes like me logo Genes that share phenotypes with SEL1L3: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEL1L3 Gene

Localization for SEL1L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEL1L3 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEL1L3 gene
Compartment Confidence
nucleus 3
plasma membrane 2
mitochondrion 1
peroxisome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SEL1L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SEL1L3: view

Pathways & Interactions for SEL1L3 Gene

SuperPathways for SEL1L3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SEL1L3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SEL1L3 Gene

Transcripts for SEL1L3 Gene

Unigene Clusters for SEL1L3 Gene

Sel-1 suppressor of lin-12-like 3 (C. elegans):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEL1L3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: - - - - -
SP2: - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

ExUns: 25a · 25b · 25c ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30a · 30b
SP1: - - - -
SP2: - -
SP3:
SP4: - - -
SP5: - - -
SP6: - -
SP7:
SP8:

Relevant External Links for SEL1L3 Gene

GeneLoc Exon Structure for
SEL1L3
ECgene alternative splicing isoforms for
SEL1L3

Expression for SEL1L3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SEL1L3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEL1L3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.3) and Spleen (x4.1).

Protein differential expression in normal tissues from HIPED for SEL1L3 Gene

This gene is overexpressed in Lung (29.5) and Blymphocyte (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SEL1L3 Gene



NURSA nuclear receptor signaling pathways regulating expression of SEL1L3 Gene:

SEL1L3

SOURCE GeneReport for Unigene cluster for SEL1L3 Gene:

Hs.479384
genes like me logo Genes that share expression patterns with SEL1L3: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SEL1L3 Gene

Orthologs for SEL1L3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEL1L3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEL1L3 34 35
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia SEL1L3 34 35
  • 90.99 (n)
cow
(Bos Taurus)
Mammalia SEL1L3 34 35
  • 90.16 (n)
rat
(Rattus norvegicus)
Mammalia Sel1l3 34
  • 85.95 (n)
mouse
(Mus musculus)
Mammalia Sel1l3 34 16 35
  • 85.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 81 (a)
OneToMany
-- 35
  • 79 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SEL1L3 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEL1L3 34 35
  • 70.04 (n)
lizard
(Anolis carolinensis)
Reptilia SEL1L3 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sel1l3 34
  • 58.12 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01079870.1 35
  • 32 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hrd3 35
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sel-1 35
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRD3 35
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5716 35
  • 22 (a)
OneToMany
Species where no ortholog for SEL1L3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEL1L3 Gene

ENSEMBL:
Gene Tree for SEL1L3 (if available)
TreeFam:
Gene Tree for SEL1L3 (if available)

Paralogs for SEL1L3 Gene

Paralogs for SEL1L3 Gene

genes like me logo Genes that share paralogs with SEL1L3: view

Variants for SEL1L3 Gene

Sequence variations from dbSNP and Humsavar for SEL1L3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10000609 -- 25,814,426(+) CTACA(A/G)TAAGA intron-variant
rs10000681 -- 25,752,335(+) tggca(A/T)gaacc intron-variant
rs10002995 -- 25,737,569(+) aaatg(C/T)tatcc intron-variant
rs10003533 -- 25,850,133(+) AGGTT(A/G)AAAAG intron-variant
rs10005182 -- 25,743,252(+) AGTGG(G/T)CCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEL1L3 Gene

Variant ID Type Subtype PubMed ID
nsv997544 CNV gain 25217958
nsv477381 CNV novel sequence insertion 20440878
nsv1129723 CNV tandem duplication 24896259
nsv1126684 CNV deletion 24896259
nsv1074701 CNV deletion 25765185
nsv1010437 CNV loss 25217958
esv3893899 CNV loss 25118596
esv3444154 CNV duplication 20981092
esv1014224 CNV insertion 17803354

Variation tolerance for SEL1L3 Gene

Residual Variation Intolerance Score: 25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.05; 68.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEL1L3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEL1L3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEL1L3 Gene

Disorders for SEL1L3 Gene

Relevant External Links for SEL1L3

Genetic Association Database (GAD)
SEL1L3
Human Genome Epidemiology (HuGE) Navigator
SEL1L3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEL1L3

No disorders were found for SEL1L3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEL1L3 Gene

Publications for SEL1L3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  2. Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease. (PMID: 20708005) Chalasani N. … Rotter J.I. (Gastroenterology 2010) 3 46 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction. (PMID: 24667918) Woollard S.M. … Kanmogne G.D. (J. Cereb. Blood Flow Metab. 2014) 3 64
  5. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B. … Wang L.S. (J. Proteome Res. 2012) 3 64

Products for SEL1L3 Gene

Sources for SEL1L3 Gene

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