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Aliases for SEL1L3 Gene

Aliases for SEL1L3 Gene

  • Sel-1 Suppressor Of Lin-12-Like 3 (C. Elegans) 2 3
  • Suppressor Of Lin-12-Like Protein 3 3 4
  • Sel-1L3 3 4
  • Protein Sel-1 Homolog 3 3
  • KIAA0746 Protein 2
  • KIAA0746 4

External Ids for SEL1L3 Gene

Summaries for SEL1L3 Gene

GeneCards Summary for SEL1L3 Gene

SEL1L3 (Sel-1 Suppressor Of Lin-12-Like 3 (C. Elegans)) is a Protein Coding gene. An important paralog of this gene is SEL1L.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEL1L3 Gene

Genomics for SEL1L3 Gene

Genomic Location for SEL1L3 Gene

Start:
25,747,427 bp from pter
End:
25,863,760 bp from pter
Size:
116,334 bases
Orientation:
Minus strand

Genomic View for SEL1L3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEL1L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEL1L3 Gene

No data available for Regulatory Elements for SEL1L3 Gene

Proteins for SEL1L3 Gene

  • Protein details for SEL1L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68CR1-SE1L3_HUMAN
    Recommended name:
    Protein sel-1 homolog 3
    Protein Accession:
    Q68CR1
    Secondary Accessions:
    • A0PJH6
    • A8K0X2
    • O94847
    • Q6P999
    • Q96G59

    Protein attributes for SEL1L3 Gene

    Size:
    1132 amino acids
    Molecular mass:
    128567 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH29422.1; Type=Miscellaneous discrepancy; Note=Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH60867.1; Type=Frameshift; Positions=65; Evidence={ECO:0000305};

    Alternative splice isoforms for SEL1L3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEL1L3 Gene

Proteomics data for SEL1L3 Gene at MOPED

Post-translational modifications for SEL1L3 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn201, Asn382, Asn527, and Asn937

No data available for DME Specific Peptides for SEL1L3 Gene

Domains for SEL1L3 Gene

Protein Domains for SEL1L3 Gene

UniProtKB/Swiss-Prot:

SE1L3_HUMAN
Similarity:
  • Contains 8 Sel1-like repeats.:
    • Q68CR1
genes like me logo Genes that share domains with SEL1L3: view

No data available for Gene Families for SEL1L3 Gene

Function for SEL1L3 Gene

Phenotypes for SEL1L3 Gene

GenomeRNAi human phenotypes for SEL1L3:
genes like me logo Genes that share phenotypes with SEL1L3: view

miRNA for SEL1L3 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEL1L3 Gene

Localization for SEL1L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEL1L3 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEL1L3 Gene COMPARTMENTS Subcellular localization image for SEL1L3 gene
Compartment Confidence
plasma membrane 2
cytosol 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SEL1L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SEL1L3: view

Pathways for SEL1L3 Gene

SuperPathways for SEL1L3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SEL1L3 Gene

None

No data available for Pathways by source for SEL1L3 Gene

Transcripts for SEL1L3 Gene

Unigene Clusters for SEL1L3 Gene

Sel-1 suppressor of lin-12-like 3 (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEL1L3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: - - - - -
SP2: - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

ExUns: 25a · 25b · 25c ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30a · 30b
SP1: - - - -
SP2: - -
SP3:
SP4: - - -
SP5: - - -
SP6: - -
SP7:
SP8:

Relevant External Links for SEL1L3 Gene

GeneLoc Exon Structure for
SEL1L3
ECgene alternative splicing isoforms for
SEL1L3

Expression for SEL1L3 Gene

mRNA expression in normal human tissues for SEL1L3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEL1L3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (4.3) and Spleen (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEL1L3 Gene

SOURCE GeneReport for Unigene cluster for SEL1L3 Gene Hs.479384

genes like me logo Genes that share expressions with SEL1L3: view

Orthologs for SEL1L3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEL1L3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEL1L3 36
  • 99.66 (n)
  • 99.59 (a)
SEL1L3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SEL1L3 36
  • 90.16 (n)
  • 91.96 (a)
SEL1L3 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SEL1L3 36
  • 90.99 (n)
  • 92.48 (a)
SEL1L3 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sel1l3 36
  • 85.69 (n)
  • 86.48 (a)
Sel1l3 16
Sel1l3 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SEL1L3 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 79 (a)
OneToMany
-- 37
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Sel1l3 36
  • 85.95 (n)
  • 85.69 (a)
chicken
(Gallus gallus)
Aves SEL1L3 36
  • 70.04 (n)
  • 67.73 (a)
SEL1L3 37
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEL1L3 37
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sel1l3 36
  • 58.12 (n)
  • 48.17 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01079870.1 37
  • 32 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hrd3 37
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sel-1 37
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRD3 37
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5716 37
  • 22 (a)
OneToMany
Species with no ortholog for SEL1L3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEL1L3 Gene

ENSEMBL:
Gene Tree for SEL1L3 (if available)
TreeFam:
Gene Tree for SEL1L3 (if available)

Paralogs for SEL1L3 Gene

Paralogs for SEL1L3 Gene

genes like me logo Genes that share paralogs with SEL1L3: view

Variants for SEL1L3 Gene

Sequence variations from dbSNP and Humsavar for SEL1L3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs2437 -- 25,847,741(-) GCAAC(A/G)TTTCT missense, reference, utr-variant-5-prime
rs7701 -- 25,747,681(-) GCAAC(G/T)GAATA utr-variant-3-prime
rs11838 -- 25,747,686(-) TGGCA(A/G)CAACG utr-variant-3-prime
rs729317 -- 25,817,052(-) TTCTG(C/T)CCTTG intron-variant
rs748816 -- 25,817,812(+) ttttt(A/T)aaaac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEL1L3 Gene

Variant ID Type Subtype PubMed ID
nsv878761 CNV Gain 21882294
nsv878765 CNV Gain 21882294
nsv878766 CNV Gain 21882294
esv1014224 CNV Insertion 17803354

Relevant External Links for SEL1L3 Gene

HapMap Linkage Disequilibrium report
SEL1L3

Disorders for SEL1L3 Gene

Relevant External Links for SEL1L3

Genetic Association Database (GAD)
SEL1L3
Human Genome Epidemiology (HuGE) Navigator
SEL1L3
genes like me logo Genes that share disorders with SEL1L3: view

No data available for UniProtKB/Swiss-Prot for SEL1L3 Gene

Publications for SEL1L3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease. (PMID: 20708005) Chalasani N. … Rotter J.I. (Gastroenterology 2010) 3 49
  3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  4. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B. … Wang L.S. (J. Proteome Res. 2012) 3
  5. Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction. (PMID: 24667918) Woollard S.M. … Kanmogne G.D. (J. Cereb. Blood Flow Metab. 2014) 3

Products for SEL1L3 Gene

Sources for SEL1L3 Gene

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