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Aliases for SEL1L3 Gene

Aliases for SEL1L3 Gene

  • SEL1L Family Member 3 2 3 5
  • Suppressor Of Lin-12-Like Protein 3 3 4
  • Sel-1L3 3 4
  • Sel-1 Suppressor Of Lin-12-Like 3 (C. Elegans) 2
  • Sel-1 Suppressor Of Lin-12-Like 3 3
  • Protein Sel-1 Homolog 3 3
  • KIAA0746 Protein 2
  • KIAA0746 4

External Ids for SEL1L3 Gene

Previous GeneCards Identifiers for SEL1L3 Gene

  • GC04M025358
  • GC04M025749
  • GC04M025087
  • GC04M025756
  • GC04M025763
  • GC04M025766
  • GC04M025770
  • GC04M025774
  • GC04M025778

Summaries for SEL1L3 Gene

GeneCards Summary for SEL1L3 Gene

SEL1L3 (SEL1L Family Member 3) is a Protein Coding gene. An important paralog of this gene is SEL1L.

Additional gene information for SEL1L3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEL1L3 Gene

Genomics for SEL1L3 Gene

Regulatory Elements for SEL1L3 Gene

Enhancers for SEL1L3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H025912 1.1 ENCODE 16.8 -50.5 -50519 2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 SMIM20 SEL1L3 ANAPC4 ZCCHC4 PI4K2B SEPSECS LOC105374538 PIR49686
GH04H025874 1.3 FANTOM5 ENCODE dbSUPER 11.5 -11.9 -11856 3 PKNOX1 MAX BACH1 BMI1 EED ATF7 RUNX3 IKZF2 CREM CHD2 SEL1L3 ENSG00000251009 GC04M025896
GH04H025908 1 Ensembl ENCODE 11.3 -44.8 -44839 0 SOX13 TFAP4 FOXA2 SAP130 JUN ARID4B ZNF140 ZNF644 FOSL1 POLR2A ANAPC4 SMIM20 ZCCHC4 SEL1L3 STIM2 LOC105374538 GC04M025896
GH04H025879 0.8 dbSUPER 11.6 -15.9 -15901 0 BCOR PKNOX1 ZMYM3 ZFHX2 POLR2A ZNF207 RUNX3 IKZF2 CREM EGR2 SEL1L3 SMIM20 ENSG00000251009 GC04M025896
GH04H025834 0.7 ENCODE dbSUPER 12.1 +28.8 28824 0 GATA2 ADNP SMIM20 SEL1L3 LOC102723733 ENSG00000250541
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SEL1L3 on UCSC Golden Path with GeneCards custom track

Promoters for SEL1L3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000166928 1160 2001 TBP RB1 TBL1XR1 NFRKB RAD21 ZNF766 ZNF366 SCRT2 ATF7 IKZF2

Genomic Location for SEL1L3 Gene

Chromosome:
4
Start:
25,721,867 bp from pter
End:
25,863,760 bp from pter
Size:
141,894 bases
Orientation:
Minus strand

Genomic View for SEL1L3 Gene

Genes around SEL1L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEL1L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEL1L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEL1L3 Gene

Proteins for SEL1L3 Gene

  • Protein details for SEL1L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68CR1-SE1L3_HUMAN
    Recommended name:
    Protein sel-1 homolog 3
    Protein Accession:
    Q68CR1
    Secondary Accessions:
    • A0PJH6
    • A8K0X2
    • O94847
    • Q6P999
    • Q96G59

    Protein attributes for SEL1L3 Gene

    Size:
    1132 amino acids
    Molecular mass:
    128567 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH29422.1; Type=Miscellaneous discrepancy; Note=Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH60867.1; Type=Frameshift; Positions=65; Evidence={ECO:0000305};

    Alternative splice isoforms for SEL1L3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEL1L3 Gene

Post-translational modifications for SEL1L3 Gene

  • Glycosylation at isoforms=2, 3201, Asn382, Asn527, and isoforms=2, 3937
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SEL1L3 Gene

Domains & Families for SEL1L3 Gene

Gene Families for SEL1L3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SEL1L3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SEL1L3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SEL1L3: view

No data available for UniProtKB/Swiss-Prot for SEL1L3 Gene

Function for SEL1L3 Gene

Phenotypes From GWAS Catalog for SEL1L3 Gene

Phenotypes for SEL1L3 Gene

GenomeRNAi human phenotypes for SEL1L3:
genes like me logo Genes that share phenotypes with SEL1L3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SEL1L3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEL1L3 Gene

Localization for SEL1L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEL1L3 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEL1L3 gene
Compartment Confidence
nucleus 3
plasma membrane 2
mitochondrion 1
peroxisome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SEL1L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SEL1L3: view

Pathways & Interactions for SEL1L3 Gene

SuperPathways for SEL1L3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SEL1L3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SEL1L3 Gene

Drugs & Compounds for SEL1L3 Gene

No Compound Related Data Available

Transcripts for SEL1L3 Gene

Unigene Clusters for SEL1L3 Gene

Sel-1 suppressor of lin-12-like 3 (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SEL1L3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SEL1L3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: - - - - -
SP2: - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

ExUns: 25a · 25b · 25c ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30a · 30b
SP1: - - - -
SP2: - -
SP3:
SP4: - - -
SP5: - - -
SP6: - -
SP7:
SP8:

Relevant External Links for SEL1L3 Gene

GeneLoc Exon Structure for
SEL1L3
ECgene alternative splicing isoforms for
SEL1L3

Expression for SEL1L3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEL1L3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEL1L3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.3) and Spleen (x4.1).

Protein differential expression in normal tissues from HIPED for SEL1L3 Gene

This gene is overexpressed in Lung (29.5) and Blymphocyte (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SEL1L3 Gene



NURSA nuclear receptor signaling pathways regulating expression of SEL1L3 Gene:

SEL1L3

SOURCE GeneReport for Unigene cluster for SEL1L3 Gene:

Hs.479384

Evidence on tissue expression from TISSUES for SEL1L3 Gene

  • Nervous system(4.5)
  • Muscle(4.1)
  • Intestine(2.9)
  • Lung(2.9)
genes like me logo Genes that share expression patterns with SEL1L3: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEL1L3 Gene

Orthologs for SEL1L3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEL1L3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEL1L3 33 34
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia SEL1L3 33 34
  • 90.99 (n)
cow
(Bos Taurus)
Mammalia SEL1L3 33 34
  • 90.16 (n)
rat
(Rattus norvegicus)
Mammalia Sel1l3 33
  • 85.95 (n)
mouse
(Mus musculus)
Mammalia Sel1l3 33 16 34
  • 85.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 81 (a)
OneToMany
-- 34
  • 79 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SEL1L3 34
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEL1L3 33 34
  • 70.04 (n)
lizard
(Anolis carolinensis)
Reptilia SEL1L3 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sel1l3 33
  • 58.12 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01079870.1 34
  • 32 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hrd3 34
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sel-1 34
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRD3 34
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5716 34
  • 22 (a)
OneToMany
Species where no ortholog for SEL1L3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEL1L3 Gene

ENSEMBL:
Gene Tree for SEL1L3 (if available)
TreeFam:
Gene Tree for SEL1L3 (if available)

Paralogs for SEL1L3 Gene

Paralogs for SEL1L3 Gene

genes like me logo Genes that share paralogs with SEL1L3: view

Variants for SEL1L3 Gene

Sequence variations from dbSNP and Humsavar for SEL1L3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000017682 -- 25,809,058(+) ACAGA(A/G)TGAGA intron-variant
rs1000018967 -- 25,739,936(+) CATCA(A/G)TGTAT intron-variant
rs1000041555 -- 25,819,374(+) GTCAC(C/T)ATTCA intron-variant
rs1000042003 -- 25,720,316(+) TTATT(-/G)GGTCA intron-variant
rs10000609 -- 25,814,426(+) CTACA(A/G)TAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEL1L3 Gene

Variant ID Type Subtype PubMed ID
esv1014224 CNV insertion 17803354
esv3444154 CNV duplication 20981092
esv3893899 CNV loss 25118596
nsv1010437 CNV loss 25217958
nsv1074701 CNV deletion 25765185
nsv1126684 CNV deletion 24896259
nsv1129723 CNV tandem duplication 24896259
nsv477381 CNV novel sequence insertion 20440878
nsv997544 CNV gain 25217958

Variation tolerance for SEL1L3 Gene

Residual Variation Intolerance Score: 25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.05; 68.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEL1L3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEL1L3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEL1L3 Gene

Disorders for SEL1L3 Gene

Relevant External Links for SEL1L3

Genetic Association Database (GAD)
SEL1L3
Human Genome Epidemiology (HuGE) Navigator
SEL1L3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEL1L3

No disorders were found for SEL1L3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEL1L3 Gene

Publications for SEL1L3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 60
  2. Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease. (PMID: 20708005) Chalasani N … Nonalcoholic Steatohepatitis Clinical Research Network (Gastroenterology 2010) 3 45 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction. (PMID: 24667918) Woollard SM … Kanmogne GD (Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2014) 3 60

Products for SEL1L3 Gene

Sources for SEL1L3 Gene

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