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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEL1L3 Gene

protein-coding   GIFtS: 47
GCID: GC04M025749

sel-1 suppressor of lin-12-like 3 (C. elegans)

 Explore 5 diseases affiliated with
SEL1L3 via our new
 Human Malady Compendium 
Biological research products
for SEL1L3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Sel-1 Suppressor Of Lin-12-Like 3 (C. Elegans)1 2
KIAA07461 3
Suppressor Of Lin-12-Like Protein 32 3
Sel-1L32 3
Protein Sel-1 Homolog 32

External Ids:    HGNC: 291081   Entrez Gene: 232312   Ensembl: ENSG000000914907   UniProtKB: Q68CR13   

Export aliases for SEL1L3 gene to outside databases

Previous GC identifers: GC04M025358 GC04M025087


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006316.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SEL1L3
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SEL1L3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEL1L3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15.2   Ensembl cytogenetic band:  4p15.2   HGNC cytogenetic band: 4p15.2

SEL1L3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEL1L3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M025749:  view genomic region     (about GC identifiers)

Start:
25,749,049 bp from pter      End:
25,865,382 bp from pter
Size:
116,334 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SE1L3_HUMAN, Q68CR1 (See protein sequence)
Recommended Name: Protein sel-1 homolog 3  
Size: 1132 amino acids; 128567 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=AAH29422.1; Type=Miscellaneous discrepancy; Note=Potential poly-A sequence;
Sequence=AAH60867.1; Type=Frameshift; Positions=65;
Secondary accessions: A0PJH6 A8K0X2 O94847 Q6P999 Q96G59
Alternative splicing: 3 isoforms:  Q68CR1-1   Q68CR1-2   Q68CR1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEL1L3: NX_Q68CR1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q68CR1

  • SEL1L3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_056002.2  
    ENSEMBL proteins: 
     ENSP00000382767   ENSP00000264868   ENSP00000425438   ENSP00000421701   ENSP00000426050  
     ENSP00000424564   ENSP00000423743   ENSP00000421567   ENSP00000420951  

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    Novus Biologicals SEL1L3 Protein
    Novus Biologicals SEL1L3 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SEL1L3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    SEL1L3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SEL1L3


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SEL1L3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR011990 TPR-like_helical
     IPR006597 Sel1-like

    Graphical View of Domain Structure for InterPro Entry Q68CR1

    ProtoNet protein and cluster: Q68CR1

    UniProtKB/Swiss-Prot: SE1L3_HUMAN, Q68CR1
    Similarity: Contains 8 Sel1-like repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEL1L3
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    hsa-miR-142-5p hsa-miR-548j hsa-miR-26a-2* hsa-miR-3607-3p hsa-miR-548k hsa-miR-15a hsa-miR-25 hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidSEL1L3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene shRNA RFP: SEL1L3
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEL1L3

    2 GenomeRNAi human phenotypes for SEL1L3:
     Big cells  Increased cell number in G2M,  


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEL1L3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/8 Interacting proteins for SEL1L3 (Q68CR12, 3 ENSP000003827674) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000258947Q135093I2D: score=2 
    TUBB3Q135093I2D: score=2 
    TUBB4AP043503, ENSP000002640714I2D: score=1 STRING: ENSP00000264071
    TLN1Q9Y4903I2D: score=1 
    VCLP182063I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEL1L3
    Search CenterWatch for drugs/clinical trials and news about SEL1L3 / SE1L3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SEL1L3 gene: 
    NM_015187.3  

    Unigene Cluster for SEL1L3:

    Sel-1 suppressor of lin-12-like 3 (C. elegans)
    Hs.479384  [show with all ESTs]
    Unigene Representative Sequence: NM_015187
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399878(uc003gru.4) ENST00000264868 ENST00000513416 ENST00000512286
    ENST00000502949(uc003grv.3) ENST00000510448 ENST00000507618 ENST00000509290
    ENST00000514321 ENST00000513364 ENST00000510880 ENST00000513691 ENST00000514872


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SEL1L3
    8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate SEL1L3 (see all 62):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-26a-2* hsa-miR-3607-3p hsa-miR-548k hsa-miR-15a hsa-miR-25 hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidSEL1L3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEL1L3
    OriGene shRNA RFP: SEL1L3
    OriGene siRNA: SEL1L3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SEL1L3
    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEL1L3 (see all 2)
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    Additional cDNA sequence: 

    AB018289.1 AK025282.1 AK123293.1 AK289687.1 AK300219.1 BC009945.2 BC029422.1 BC041046.1 
    BC060867.1 CR749817.1 

    16 DOTS entries:

    DT.99995407  DT.448366  DT.92430764  DT.101957911  DT.441661  DT.454814  DT.443434  DT.100822390 
    DT.40215611  DT.101984898  DT.121220009  DT.91702129  DT.91743764  DT.95336612  DT.95336633  DT.95336641 

    24/327 AceView cDNA sequences (see all 327):

    AW513121 AA553695 AA376661 BM747424 BM662772 BM697662 BM713156 AA580462 
    AA159610 AA723803 BU543114 BE267561 AI439991 BC029422 AI269788 AA827940 
    AI625463 AW574499 AA625247 BQ061836 BX116727 BM771425 BC041046 BQ941512 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SEL1L3 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                                                  -                                   -     -                                         -     -               
    SP2:                                                                                      -     -                                         -     -               
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 25a · 25b · 25c ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30a · 30b
    SP1:                    -           -                 -     -               
    SP2:                    -           -                                       
    SP3:                                                                        
    SP4:                    -           -                 -                     
    SP5:                                -                 -     -               


    ECgene alternative splicing isoforms for SEL1L3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEL1L3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGCTAAGGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    SEL1L3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleHyoid Arch MusclesMuscle Progenitor CellsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMuscle Progenitor CellsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)

    See SEL1L3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEL1L3

    SOURCE GeneReport for Unigene cluster: Hs.479384
        SABiosciences Custom PCR Arrays for SEL1L3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEL1L3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for SEL1L3 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sel1l31 , 5 sel-1 suppressor of lin-12-like 3 (C. elegans)1, 5 85.92(n)1
    86.93(a)1
      5 (28.96 cM)5
    2312381  NM_172710.31  NP_766298.21 
     531070845 
    chicken
    (Gallus gallus)
    Aves SEL1L31 sel-1 suppressor of lin-12-like 3 (C. elegans) 70.04(n)
    67.73(a)
      422804  XM_420754.3  XP_420754.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    69(a)
    1 ↔ 1
    GL343348.1(396284-412480)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5598431 uncharacterized protein LOC559843 48.42(n)
    35.95(a)
      559843  XM_683230.5  XP_688322.5 
    E. coli
    (Escherichia coli)
    Gamma proteobacteria ybeT6
    ybeQ6
    conserved protein
    19(a)
    13(a)
    many ↔ many
    many ↔ many
    Chromosome(678075-678629)
    Chromosome(674793-675770)


    ENSEMBL Gene Tree for SEL1L3 (if available)
    TreeFam Gene Tree for SEL1L3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEL1L3 gene
    SEL1L2  SEL1L22  

    SEL1L3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEL1L3
    DNA2.0 Custom Variant and Variant Library Synthesis for SEL1L3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SEL1L3 for disorders           About GeneDecksing

    5 diseases for SEL1L3:    About MalaCards
    fatty liver disease    liver disease    bipolar disorder    schizophrenia
    malaria

    Human Genome Epidemiology (HuGE) Navigator: SEL1L3 (0 documents)

    Export disorders for SEL1L3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEL1L3 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with SEL1L3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (1998)
    2. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    4. Genome-wide association study identifies variants ass ociated with histologic features of nonalcoholic Fatty liver disease. (PubMed id 20708005)1 Chalasani N....Rotter J.I. (2010)
    5. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    6. Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia. (PubMed id 17457313)1 Christoforou A....Evans K.L. (2007)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    8. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23231 HGNC: 29108 AceView: KIAA0746 Ensembl:ENSG00000091490 euGenes: HUgn23231
    ECgene: SEL1L3 H-InvDB: SEL1L3

    (According to HUGE)
    About This Section
    HUGE: KIAA0746

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEL1L3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEL1L3 gene:
    Search GeneIP for patents involving SEL1L3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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