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Aliases for SEL1L3 Gene

Aliases for SEL1L3 Gene

  • Sel-1 Suppressor Of Lin-12-Like 3 (C. Elegans) 2 3
  • Suppressor Of Lin-12-Like Protein 3 3 4
  • Sel-1L3 3 4
  • Protein Sel-1 Homolog 3 3
  • KIAA0746 Protein 2
  • KIAA0746 4

External Ids for SEL1L3 Gene

Previous GeneCards Identifiers for SEL1L3 Gene

  • GC04M025358
  • GC04M025749
  • GC04M025087

Summaries for SEL1L3 Gene

GeneCards Summary for SEL1L3 Gene

SEL1L3 (Sel-1 Suppressor Of Lin-12-Like 3 (C. Elegans)) is a Protein Coding gene. An important paralog of this gene is SEL1L.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEL1L3 Gene

Genomics for SEL1L3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SEL1L3 Gene

25,747,427 bp from pter
25,863,760 bp from pter
116,334 bases
Minus strand

Genomic View for SEL1L3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEL1L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEL1L3 Gene

No data available for Regulatory Elements for SEL1L3 Gene

Proteins for SEL1L3 Gene

  • Protein details for SEL1L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein sel-1 homolog 3
    Protein Accession:
    Secondary Accessions:
    • A0PJH6
    • A8K0X2
    • O94847
    • Q6P999
    • Q96G59

    Protein attributes for SEL1L3 Gene

    1132 amino acids
    Molecular mass:
    128567 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH29422.1; Type=Miscellaneous discrepancy; Note=Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH60867.1; Type=Frameshift; Positions=65; Evidence={ECO:0000305};

    Alternative splice isoforms for SEL1L3 Gene


neXtProt entry for SEL1L3 Gene

Proteomics data for SEL1L3 Gene at MOPED

Post-translational modifications for SEL1L3 Gene

  • Glycosylation at Asn201, Asn382, Asn527, and Asn937
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SEL1L3 Gene

Domains for SEL1L3 Gene

Protein Domains for SEL1L3 Gene

Suggested Antigen Peptide Sequences for SEL1L3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q68CR1
  • Contains 8 Sel1-like repeats.
genes like me logo Genes that share domains with SEL1L3: view

No data available for Gene Families for SEL1L3 Gene

Function for SEL1L3 Gene

Phenotypes for SEL1L3 Gene

GenomeRNAi human phenotypes for SEL1L3:
genes like me logo Genes that share phenotypes with SEL1L3: view

Animal Model Products

CRISPR Products

miRNA for SEL1L3 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEL1L3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEL1L3 Gene

Localization for SEL1L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEL1L3 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SEL1L3 Gene COMPARTMENTS Subcellular localization image for SEL1L3 gene
Compartment Confidence
plasma membrane 2
cytosol 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SEL1L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SEL1L3: view

Pathways for SEL1L3 Gene

SuperPathways for SEL1L3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SEL1L3 Gene


No data available for Pathways by source for SEL1L3 Gene

Transcripts for SEL1L3 Gene

Unigene Clusters for SEL1L3 Gene

Sel-1 suppressor of lin-12-like 3 (C. elegans):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEL1L3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEL1L3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: - - - - -
SP2: - - - -

ExUns: 25a · 25b · 25c ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30a · 30b
SP1: - - - -
SP2: - -
SP4: - - -
SP5: - - -
SP6: - -

Relevant External Links for SEL1L3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEL1L3 Gene

mRNA expression in normal human tissues for SEL1L3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEL1L3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (4.3) and Spleen (4.1).

Protein differential expression in normal tissues for SEL1L3 Gene

This gene is overexpressed in Lung (29.5) and Blymphocyte (12.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SEL1L3 Gene

SOURCE GeneReport for Unigene cluster for SEL1L3 Gene Hs.479384

genes like me logo Genes that share expressions with SEL1L3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for SEL1L3 Gene

Orthologs for SEL1L3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEL1L3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SEL1L3 35
  • 90.16 (n)
  • 91.96 (a)
SEL1L3 36
  • 92 (a)
(Canis familiaris)
Mammalia SEL1L3 35
  • 90.99 (n)
  • 92.48 (a)
SEL1L3 36
  • 87 (a)
(Mus musculus)
Mammalia Sel1l3 35
  • 85.69 (n)
  • 86.48 (a)
Sel1l3 16
Sel1l3 36
  • 85 (a)
(Pan troglodytes)
Mammalia SEL1L3 35
  • 99.66 (n)
  • 99.59 (a)
SEL1L3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Sel1l3 35
  • 85.95 (n)
  • 85.69 (a)
(Monodelphis domestica)
Mammalia SEL1L3 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
-- 36
  • 81 (a)
(Gallus gallus)
Aves SEL1L3 35
  • 70.04 (n)
  • 67.73 (a)
SEL1L3 36
  • 65 (a)
(Anolis carolinensis)
Reptilia SEL1L3 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sel1l3 35
  • 58.12 (n)
  • 48.17 (a)
(Danio rerio)
Actinopterygii CABZ01079870.1 36
  • 32 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hrd3 36
  • 17 (a)
(Caenorhabditis elegans)
Secernentea sel-1 36
  • 20 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRD3 36
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5716 36
  • 22 (a)
Species with no ortholog for SEL1L3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEL1L3 Gene

Gene Tree for SEL1L3 (if available)
Gene Tree for SEL1L3 (if available)

Paralogs for SEL1L3 Gene

Paralogs for SEL1L3 Gene

genes like me logo Genes that share paralogs with SEL1L3: view

Variants for SEL1L3 Gene

Sequence variations from dbSNP and Humsavar for SEL1L3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs2437 -- 25,847,741(-) GCAAC(A/G)TTTCT missense, reference, utr-variant-5-prime
rs7701 -- 25,747,681(-) GCAAC(G/T)GAATA utr-variant-3-prime
rs11838 -- 25,747,686(-) TGGCA(A/G)CAACG utr-variant-3-prime
rs729317 -- 25,817,052(-) TTCTG(C/T)CCTTG intron-variant
rs748816 -- 25,817,812(+) ttttt(A/T)aaaac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SEL1L3 Gene

Variant ID Type Subtype PubMed ID
nsv878761 CNV Gain 21882294
nsv878765 CNV Gain 21882294
nsv878766 CNV Gain 21882294
esv1014224 CNV Insertion 17803354

Relevant External Links for SEL1L3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEL1L3 Gene

Disorders for SEL1L3 Gene

Relevant External Links for SEL1L3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for SEL1L3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SEL1L3 Gene

Publications for SEL1L3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease. (PMID: 20708005) Chalasani N. … Rotter J.I. (Gastroenterology 2010) 3 48
  3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  4. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B. … Wang L.S. (J. Proteome Res. 2012) 3
  5. Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction. (PMID: 24667918) Woollard S.M. … Kanmogne G.D. (J. Cereb. Blood Flow Metab. 2014) 3

Products for SEL1L3 Gene

Sources for SEL1L3 Gene

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