SEL1L3 Gene
protein-coding GIFtS : 47
GCID: GC04 M025749
sel-1 suppressor of lin-12-like 3 (C. elegans)
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Aliasesfor SEL1L3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Sel-1 Suppressor Of Lin-12-Like 3 (C. Elegans) 1 2 KIAA07461 3 Suppressor Of Lin-12-Like Protein 32 3 Sel-1L32 3 Protein Sel-1 Homolog 32
Export aliases for SEL1L3 gene to outside databases Previous GC identifers: GC04M025358 GC04M025087
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Summariesfor SEL1L3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor SEL1L3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.1 NT_006316.16 Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for SEL1L3 Other transcription factors Search SABiosciences Chromatin IP Primers for SEL1L3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SEL1L3
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4p15.2 Ensembl cytogenetic band: 4p15.2 HGNC cytogenetic band: 4p15.2 SEL1L3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04M025749: view genomic region
(about GC identifiers )
Start:
25,749,049 bp from pter
End:
25,865,382 bp from pter
Size:
116,334 bases
Orientation:
minus strand
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Proteinsfor SEL1L3 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SE1L3_HUMAN, Q68CR1 (See
protein sequence )Recommended Name: Protein sel-1 homolog 3 Size : 1132 amino acids; 128567 Da
Subcellular location : Membrane; Single-pass membrane protein (Potential)
Sequence caution : Sequence=AAH29422.1; Type=Miscellaneous discrepancy; Note=Potential poly-A sequence;Sequence=AAH60867.1; Type=Frameshift; Positions=65;
Secondary accessions : A0PJH6 A8K0X2 O94847 Q6P999 Q96G59Alternative splicing : 3 isoforms : Q68CR1-1 Q68CR1-2 Q68CR1-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SEL1L3: NX_Q68CR1 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q68CR1 SEL1L3 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_056002.2 ENSEMBL proteins: ENSP00000382767 ENSP00000264868 ENSP00000425438 ENSP00000421701 ENSP00000426050 ENSP00000424564 ENSP00000423743 ENSP00000421567 ENSP00000420951 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016021 integral to membrane
IEA --
SEL1L3 for ontologies About GeneDecksing SEL1L3 Antibody Products: Assay Products for SEL1L3:
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Protein
Domains / Familiesfor SEL1L3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SEL1L3 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q68CR1 ProtoNet protein and cluster: Q68CR1
UniProtKB/Swiss-Prot: SE1L3_HUMAN, Q68CR1 Similarity : Contains 8 Sel1-like repeats
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Functionfor SEL1L3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SEL1L3 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SEL1L3 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SEL1L3 (NM_015187 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SEL1L3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SEL1L3
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEL1L3
2 GenomeRNAi human phenotypes for SEL1L3 :
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Pathways & Interactionsfor SEL1L3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEL1L3 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)5/8 Interacting proteins for SEL1L3 (Q68CR1 2 , 3 ENSP00000382767 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 8 )About this table
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Drugs & Compoundsfor SEL1L3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SEL1L3 Search CenterWatch for drugs/clinical trials and news about SEL1L3 / SE1L3
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Transcriptsfor SEL1L3 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SEL1L3 gene: NM_015187.3 Unigene Cluster for SEL1L3:
Sel-1 suppressor of lin-12-like 3 (C. elegans) Hs.479384 [show with all ESTs ] Unigene Representative Sequence: NM_015187 13 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000399878 (uc003gru.4 ) ENST00000264868 ENST00000513416 ENST00000512286 ENST00000502949 (uc003grv.3 ) ENST00000510448 ENST00000507618 ENST00000509290 ENST00000514321 ENST00000513364 ENST00000510880 ENST00000513691 ENST00000514872 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SEL1L3 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SEL1L3 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SEL1L3 (NM_015187 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SEL1L3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SEL1L3
Additional cDNA sequence: AB018289.1 AK025282.1 AK123293.1 AK289687.1 AK300219.1 BC009945.2 BC029422.1 BC041046.1 BC060867.1 CR749817.1
16 DOTS entries : DT.99995407 DT.448366
DT.92430764 DT.101957911 DT.441661 DT.454814 DT.443434 DT.100822390 DT.40215611 DT.101984898 DT.121220009 DT.91702129 DT.91743764 DT.95336612 DT.95336633 DT.95336641 24/327 AceView cDNA sequences (see all 327 ):
AW513121 AA553695 AA376661 BM747424 BM662772 BM697662 BM713156 AA580462 AA159610 AA723803 BU543114 BE267561 AI439991 BC029422 AI269788 AA827940 AI625463 AW574499 AA625247 BQ061836 BX116727 BM771425 BC041046 BQ941512 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SEL1L3 (see all 8 ) About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ SP1 :                 -             -   -               -   -       SP2 :                             -   -               -   -       SP3 :                                                     SP4 :                                                     SP5 :                                                    
ExUns: 25a · 25b · 25c ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30a · 30b SP1 :       -     -       -   -       SP2 :       -     -               SP3 :                         SP4 :       -     -       -         SP5 :           -       -   -      
ECgene alternative splicing isoforms for SEL1L3
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Expression for SEL1L3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SEL1L3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CTGCTAAGGT
About this image SEL1L3 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See SEL1L3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SEL1L3 SOURCE GeneReport for Unigene cluster: Hs.479384 SABiosciences Custom PCR Arrays for SEL1L3 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SEL1L3Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SEL1L3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SEL1L3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SEL1L3 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEL1L3
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Orthologsfor SEL1L3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the last universal common ancestor (LUCA).
Orthologs for SEL1L3 gene from 5/15 species (see all 15 ) About this table
ENSEMBL Gene Tree for SEL1L3 (if available)TreeFam Gene Tree for SEL1L3 (if available)
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Paralogsfor SEL1L3 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SEL1L3 gene SEL1L 2 SEL1L2 2
SEL1L3 for paralogs About GeneDecksing
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Genomic Variantsfor SEL1L3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SEL1L3
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Disorders
/ Diseasesfor SEL1L3 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
SEL1L3 for disorders About GeneDecksing 5 diseases for SEL1L3 : About MalaCards fatty liver disease liver disease bipolar disorder schizophrenia malaria Human Genome Epidemiology (HuGE) Navigator: SEL1L3 (0 documents) Export disorders for SEL1L3 gene to outside databases
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Publicationsfor SEL1L3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SEL1L3 gene, integrated from 9 sources (see all 13 ): (articles sorted by number of sources associating them with SEL1L3) Utopia : connect your pdf to the dynamic world of online information
Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452) 1 , 2 , 3 Nagase T.... Ohara O. (1998) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Genome-wide association study identifies variants ass ociated with histologic features of nonalcoholic Fatty liver disease. (PubMed id 20708005) 1 Chalasani N....Rotter J.I. (2010) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 2 Dephoure N.... Gygi S.P. (2008) Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia. (PubMed id 17457313) 1 Christoforou A....Evans K.L. (2007) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070) 1 Stelzl U.... Wanker E.E. (2005) Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621) 2 Hillier L.W....Wilson R.K. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004)
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External Searches for SEL1L3 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SEL1L3 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SEL1L3 gene
(According to HUGE )
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Specialized Databases showing SEL1L3 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for SEL1L3 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for SEL1L3 gene: Search GeneIP for patents involving SEL1L3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SEL1L3 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for SEL1L3 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SEL1L3 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SEL1L3 OriGene Protein Over-expression Lysate for SEL1L3 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SEL1L3 OriGene 3'-UTR Clone for SEL1L3 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SEL1L3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SEL1L3 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for SEL1L3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SEL1L3 OriGene Custom Protein Services for SEL1L3 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SEL1L3 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SEL1L3 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SEL1L3 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SEL1L3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SEL1L3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SEL1L3
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SEL1L3 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEL1L3
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SEL1L3
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