Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SEL1L3 Gene

protein-coding   GIFtS: 53
GCID: GC04M025749

Sel-1 Suppressor Of Lin-12-Like 3 (C. Elegans)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Sel-1 Suppressor Of Lin-12-Like 3 (C. Elegans)1 2
Suppressor Of Lin-12-Like Protein 32 3
Sel-1L32 3
KIAA0746 Protein1
Protein Sel-1 Homolog 32
KIAA07463

External Ids:    HGNC: 291081   Entrez Gene: 232312   Ensembl: ENSG000000914907   UniProtKB: Q68CR13   

Export aliases for SEL1L3 gene to outside databases

Previous GC identifers: GC04M025358 GC04M025087


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SEL1L3 Gene:
SEL1L3 (sel-1 suppressor of lin-12-like 3 (C. elegans)) is a protein-coding gene. Diseases associated with SEL1L3 include fatty liver disease, and liver disease. An important paralog of this gene is SEL1L.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000004.12  NT_006316.17  NC_018915.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SEL1L3
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SEL1L3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEL1L3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15.2   Ensembl cytogenetic band:  4p15.2   HGNC cytogenetic band: 4p15.2

SEL1L3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEL1L3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M025749:  view genomic region     (about GC identifiers)

Start:
25,749,049 bp from pter      End:
25,865,382 bp from pter
Size:
116,334 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SE1L3_HUMAN, Q68CR1 (See protein sequence)
Recommended Name: Protein sel-1 homolog 3  
Size: 1132 amino acids; 128567 Da
Sequence caution: Sequence=AAH29422.1; Type=Miscellaneous discrepancy; Note=Potential poly-A sequence;
Sequence=AAH60867.1; Type=Frameshift; Positions=65;
Secondary accessions: A0PJH6 A8K0X2 O94847 Q6P999 Q96G59
Alternative splicing: 3 isoforms:  Q68CR1-1   Q68CR1-2   Q68CR1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEL1L3: NX_Q68CR1

Explore proteomics data for SEL1L3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn201, Asn382, Asn527, Asn937
  • Modification sites at PhosphoSitePlus

  • See SEL1L3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056002.2  
    ENSEMBL proteins: 
     ENSP00000382767   ENSP00000264868   ENSP00000425438   ENSP00000421701   ENSP00000426050  
     ENSP00000424564   ENSP00000423743   ENSP00000421567   ENSP00000420951  

    SEL1L3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SEL1L3
    OriGene Protein Over-expression Lysate for SEL1L3
    OriGene MassSpec for SEL1L3
    OriGene Custom Protein Services for SEL1L3
    GenScript Custom Purified and Recombinant Proteins Services for SEL1L3
    Novus Biologicals SEL1L3 Protein
    Novus Biologicals SEL1L3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SEL1L3

    SEL1L3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SEL1L3
    Novus Biologicals SEL1L3 Antibodies
    Abcam antibodies for SEL1L3
    Cloud-Clone Corp. Antibodies for SEL1L3
    ThermoFisher Antibodies for SEL1L3
    LSBio Antibodies in human, mouse, rat for SEL1L3

    SEL1L3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SEL1L3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SEL1L3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SEL1L3
    Cloud-Clone Corp. CLIAs for SEL1L3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR006597 Sel1-like
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry Q68CR1

    ProtoNet protein and cluster: Q68CR1

    UniProtKB/Swiss-Prot: SE1L3_HUMAN, Q68CR1
    Similarity: Contains 8 Sel1-like repeats


    SEL1L3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Phenotypes:
         2 GenomeRNAi human phenotypes for SEL1L3:
     Big cells  Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEL1L3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SEL1L3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SEL1L3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SEL1L3

    miRNA
    Products:
        
    miRTarBase miRNAs that target SEL1L3:
    hsa-mir-93-3p (MIRT038723), hsa-let-7a-5p (MIRT052626), hsa-mir-19b-3p (MIRT031265), hsa-mir-130b-3p (MIRT020326), hsa-mir-335-5p (MIRT018962)

    Block miRNA regulation of human, mouse, rat SEL1L3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEL1L3 (see all 62):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-26a-2* hsa-miR-3607-3p hsa-miR-548k hsa-miR-15a hsa-miR-25 hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidSEL1L3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SEL1L3
    Predesigned siRNA for gene silencing in human, mouse, rat SEL1L3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SEL1L3

    Clone
    Products:
         
    OriGene clones in human, mouse for SEL1L3 (see all 7)
    OriGene ORF clones in mouse, rat for SEL1L3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEL1L3 (NM_015187)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEL1L3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEL1L3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SEL1L3
    Browse ESI BIO Cell Lines and PureStem Progenitors for SEL1L3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEL1L3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SE1L3_HUMAN, Q68CR1: Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane2
    cytosol1
    golgi apparatus1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    SEL1L3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SEL1L3
    Interactions:

        Search GeneGlobe Interaction Network for SEL1L3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for SEL1L3 (Q68CR12, 3 ENSP000003827674) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000258947Q135093I2D: score=2 
    TUBB3Q135093I2D: score=2 
    TUBB4AP043503, ENSP000002640714I2D: score=1 STRING: ENSP00000264071
    TLN1Q9Y4903I2D: score=1 
    VCLP182063I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SEL1L3 (SE1L3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SEL1L3 gene: 
    NM_015187.3  

    Unigene Cluster for SEL1L3:

    Sel-1 suppressor of lin-12-like 3 (C. elegans)
    Hs.479384  [show with all ESTs]
    Unigene Representative Sequence: NM_015187
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399878(uc003gru.4) ENST00000264868 ENST00000513416 ENST00000512286
    ENST00000502949(uc003grv.3) ENST00000510448 ENST00000507618 ENST00000509290
    ENST00000514321 ENST00000513364 ENST00000510880 ENST00000513691 ENST00000514872

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SEL1L3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SEL1L3 (see all 62):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-26a-2* hsa-miR-3607-3p hsa-miR-548k hsa-miR-15a hsa-miR-25 hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidSEL1L3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SEL1L3
    Predesigned siRNA for gene silencing in human, mouse, rat SEL1L3
    Clone
    Products:
         
    OriGene clones in human, mouse for SEL1L3 (see all 7)
    OriGene ORF clones in mouse, rat for SEL1L3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SEL1L3 (NM_015187)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SEL1L3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEL1L3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SEL1L3
    OriGene qSTAR qPCR primer pairs in human, mouse for SEL1L3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEL1L3
      QuantiTect SYBR Green Assays in human, mouse, rat SEL1L3
      QuantiFast Probe-based Assays in human, mouse, rat SEL1L3

    Additional mRNA sequence: 

    AB018289.1 AK025282.1 AK123293.1 AK289687.1 AK300219.1 BC009945.2 BC029422.1 BC041046.1 
    BC060867.1 CR749817.1 

    16 DOTS entries:

    DT.99995407  DT.448366  DT.92430764  DT.454814  DT.101957911  DT.441661  DT.443434  DT.100822390 
    DT.40215611  DT.101984898  DT.121220009  DT.91702129  DT.91743764  DT.95336612  DT.95336633  DT.95336641 

    Selected AceView cDNA sequences (see all 327):

    AA827940 AA323981 AA159610 AA811523 AW451417 AW513121 AB018289 CN478756 
    CK821039 AA159740 AI269788 CD109007 BM791334 BE551031 AW574499 CK821038 
    CA311382 AA625247 BQ941512 BU631295 BM744366 AI216092 BQ028263 BX356112 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SEL1L3 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                                                  -                                   -     -                                         -     -               
    SP2:                                                                                      -     -                                         -     -               
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 25a · 25b · 25c ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30a · 30b
    SP1:                    -           -                 -     -               
    SP2:                    -           -                                       
    SP3:                                                                        
    SP4:                    -           -                 -                     
    SP5:                                -                 -     -               


    ECgene alternative splicing isoforms for SEL1L3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SEL1L3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCTAAGGT
    SEL1L3 Expression
    About this image


    SEL1L3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 2 entries
             Notochord Cells Notochord
             Notochord
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Mesoderm (Gastrulation Derivatives)
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
     
     Cartilage (Muscoskeletal System)
             Notochord Cells Notochord
    SEL1L3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SEL1L3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.479384
        Custom PCR Arrays for SEL1L3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SEL1L3
    OriGene qSTAR qPCR primer pairs in human, mouse for SEL1L3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEL1L3
    QuantiTect SYBR Green Assays in human, mouse, rat SEL1L3
    QuantiFast Probe-based Assays in human, mouse, rat SEL1L3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEL1L3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SEL1L3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sel1l31 , 5 sel-1 suppressor of lin-12-like 3 (C. elegans)1, 5 85.69(n)1
    86.48(a)1
      5 (28.96 cM)5
    2312381  NM_172710.31  NP_766298.21 
     531070845 
    chicken
    (Gallus gallus)
    Aves SEL1L31 sel-1 suppressor of lin-12-like 3 (C. elegans) 70.04(n)
    67.73(a)
      422804  XM_420754.4  XP_420754.3 
    lizard
    (Anolis carolinensis)
    Reptilia SEL1L36
    sel-1 suppressor of lin-12-like 3 (C. elegans)
    57(a)
    1 ↔ 1
    GL343348.1(389812-438709)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sel1l31 sel-1 suppressor of lin-12-like 3 (C. elegans) 58.12(n)
    48.17(a)
      100492622  XM_002939102.2  XP_002939148.2 
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01079870.16
    Uncharacterized protein
    32(a)
    1 ↔ 1
    23(1127391-1136253) ENSDARG00000089049
    fruit fly
    (Drosophila melanogaster)
    Insecta Hrd36
    --
    17(a)
    1 → many
    3R(19580345-19584279)
    worm
    (Caenorhabditis elegans)
    Secernentea sel-16
    Protein SEL-1 (sel-1) mRNA, complete cds
    20(a)
    1 → many
    V(12560732-12563386) WBGene00004759
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HRD36
    Resident protein of the ER membrane that plays a c...
    12(a)
    1 → many
    XII(556788-559289) YLR207W


    ENSEMBL Gene Tree for SEL1L3 (if available)
    TreeFam Gene Tree for SEL1L3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SEL1L3 gene
    SEL1L2  SEL1L22  

    SEL1L3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SEL1L3 (see all 2592)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1394808661,2
    --25748553(+) AATCCC/TAAGAG 1 -- int10--------
    rs100154491,2
    C--25748571(+) TCATCG/ACCCCA 1 -- int14Minor allele frequency- A:0.09CSA WA NA EA 360
    rs117357191,2
    C,F,H--25748784(+) TGGAAT/CGAACA 1 -- int117Minor allele frequency- C:0.06NS EA NA 2048
    rs1824911041,2
    --25748955(+) GGAGGA/TCTTTT 1 -- int10--------
    rs1401504341,2
    C--25749033(+) AGGGG-/AAAAAA 1 -- int10--------
    rs1867299751,2
    --25749033(+) AGGGGA/GAAAAA 1 -- int10--------
    rs1114377151,2
    C,F--25749160(+) GCAGCT/ATGTAG 1 -- ut311Minor allele frequency- A:0.50CSA 2
    rs1474481611,2
    C--25749200(+) CTCTA-/ACACACA 1 -- ut310--------
    rs1443665071,2
    C--25749285(+) AGAGGC/TTTACT 1 -- ut310--------
    rs77011,2
    C,F,O,A,H--25749303(-) GCAACG/TGAATA 1 -- ut31 ese322Minor allele frequency- T:0.44MN NS EA NA CSA WA 2710

    HapMap Linkage Disequilibrium report for SEL1L3 (25749049 - 25865382 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SEL1L3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1014224CNV Insertion17803354
    nsv878766CNV Gain21882294
    nsv878765CNV Gain21882294
    nsv878761CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SEL1L3
    DNA2.0 Custom Variant and Variant Library Synthesis for SEL1L3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    5 diseases for SEL1L3:    
    About MalaCards
    fatty liver disease    liver disease    bipolar disorder    schizophrenia
    endotheliitis


    SEL1L3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SEL1L3
    Human Genome Epidemiology (HuGE) Navigator: SEL1L3 (0 documents)

    Export disorders for SEL1L3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SEL1L3 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with SEL1L3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    2. Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease. (PubMed id 20708005)1, 4 Chalasani N....Rotter J.I. (Gastroenterology 2010)
    3. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    7. Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia. (PubMed id 17457313)1 Christoforou A....Evans K.L. (Mol. Psychiatry 2007)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    9. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    10. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23231 HGNC: 29108 AceView: KIAA0746 Ensembl:ENSG00000091490 euGenes: HUgn23231
    ECgene: SEL1L3 H-InvDB: SEL1L3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0746

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SEL1L3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SEL1L3 gene:
    Search GeneIP for patents involving SEL1L3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SEL1L3  
     OriGene qPCR primer pairs and template standards for SEL1L3   OriGene Protein Over-expression Lysate for SEL1L3  
     OriGene MassSpec something-or-other for SEL1L3   OriGene clones in human, mouse for SEL1L3  
     OriGene qSTAR qPCR primer pairs in human, mouse for SEL1L3   OriGene Purified Protein for SEL1L3  
     OriGene ORF clones in mouse, rat for SEL1L3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SEL1L3   OriGene Custom Protein Services for SEL1L3  

     
     
     Block miRNA regulation of human, mouse, rat SEL1L3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SEL1L3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SEL1L3 Predesigned siRNA for gene silencing in human, mouse, rat SEL1L3
     QuantiFast Probe-based Assays in human, mouse, rat SEL1L3 QuantiTect SYBR Green Assays in human, mouse, rat SEL1L3
     Custom PCR Arrays for SEL1L3 Search Chromatin IP Primers for SEL1L3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SEL1L3  Search GeneGlobe Interaction Network for SEL1L3
     Search Regulatory tfbs for SEL1L3
     GenScript Custom Purified and Recombinant Proteins Services for SEL1L3 GenScript cDNA clones with any tag delivered in your preferred vector for SEL1L3
     GenScript Custom Assay Services for SEL1L3 GenScript Custom overexpressing Cell Line Services for SEL1L3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SEL1L3 (SE1L3)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SEL1L3 antibodies
     SEL1L3 proteins
     SEL1L3 lysates
     Antibodies for SEL1L3
     See all of Abcam's Antibodies, Kits and Proteins for SEL1L3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SEL1L3
     Antibodies for SEL1L3
     ELISAs for SEL1L3
     CLIAs for SEL1L3



     Browse ESI BIO Cell Lines and PureStem Progenitors for SEL1L3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEL1L3
     SwitchGear 3'UTR luciferase reporter plasmids for SEL1L3
     Browse SwitchGear Promoter luciferase reporter plasmids for SEL1L3
     ThermoFisher Antibodies for SEL1L3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SEL1L3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SEL1L3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SEL1L3
     LSBio Antibodies in human, mouse, rat for SEL1L3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SEL1L3 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4