SEL1L2 Gene
protein-coding GIFtS: 40
GCID: GC20M013779
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sel-1 suppressor of lin-12-like 2 (C. elegans)(Previous name: chromosome 20 open reading frame 50 )
(Previous symbol: C20orf50)
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Aliases
for SEL1L2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sel-1 Suppressor Of Lin-12-Like 2 (C. Elegans)1 2 | | Chromosome 20 Open Reading Frame 501 | | C20orf501 2 3 | | Protein Sel-1 Homolog 22 | | Suppressor Of Lin-12-Like Protein 22 3 | | Sel-1L23 | | DKFZp434C18261 | | Sel-1L23 |
Export aliases for SEL1L2 gene to outside databases |
Summaries
for SEL1L2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SEL1L2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SEL1L2 gene promoter:
MIF-1 POU3F2 CBF-C RORalpha2 CBF-A CBF-B CP1C CP1A MRF-2 CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for SEL1L2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEL1L2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p12.1 Ensembl cytogenetic band: 20p12.1 HGNC cytogenetic band: 20p12.1SEL1L2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M013779: view genomic region
(about GC identifiers)
Start:
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13,829,893 bp from pter |
End:
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13,977,089 bp from pter |
Size:
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147,197 bases |
Orientation:
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minus strand |
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Proteins
for SEL1L2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SE1L2_HUMAN, Q5TEA6 (See
protein sequence)Recommended Name: Protein sel-1 homolog 2 precursor Size: 688 amino acids; 77964 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Sequence caution: Sequence=CAI22078.1; Type=Erroneous gene model prediction; Sequence=CAI22983.1; Type=Erroneous genemodel prediction;Explore the universe of human proteins at neXtProt for SEL1L2: NX_Q5TEA6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5TEA6
SEL1L2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001258468.1
ENSEMBL proteins: ENSP00000418040 ENSP00000367312 ENSP00000284951 ENSP00000394598 ENSP00000420372
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
SEL1L2 for ontologies About GeneDecksing
SEL1L2 Antibody Products:
Assay Products for SEL1L2: |
Protein
Domains /
Families
for SEL1L2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SEL1L2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5TEA6ProtoNet protein and cluster: Q5TEA6 UniProtKB/Swiss-Prot: SE1L2_HUMAN, Q5TEA6Similarity: Belongs to the sel-1 familySimilarity: Contains 11 Sel1-like repeats |
Function
for SEL1L2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEL1L2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEL1L2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEL1L2 |
|
Pathways & Interactions
for SEL1L2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEL1L2
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for SEL1L2 (ENSP000002849514) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for SEL1L2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SEL1L2
Search CenterWatch for drugs/clinical trials and news about SEL1L2 / SE1L2
|
Transcripts
for SEL1L2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SEL1L2 gene (2 alternative transcripts): NM_025229.1 NM_001271539.1 Unigene Cluster for SEL1L2: Sel-1 suppressor of lin-12-like 2 (C. elegans) Hs.590879 [show with all ESTs]Unigene Representative Sequence: BC03574111 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000482196 ENST00000475649 ENST00000378072(uc010zrl.2) ENST00000486903(uc002wor.3)
ENST00000284951 ENST00000423870(uc010gcf.3 uc002woq.4) ENST00000492548
ENST00000476952 ENST00000473203 ENST00000495437 ENST00000477435
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEL1L2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEL1L2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SEL1L2 (NM_025229) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SEL1L2 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SEL1L2 |
Additional cDNA sequence: AK302170.1 AL137678.1 BC035741.1 NR_073206.1 NR_073207.1 5 DOTS entries: DT.91722982 DT.120824197 DT.91661988 DT.91754114 DT.91661990 18 AceView cDNA sequences: BG214394 BC035741 BG217556 BF509718 AL137678 BM554202 CD359317 BG188306 BG191061 BG220573 BG184754 BG218395 BG204271 BG216522 BG203754 BG195560 BG219992 BG182541
GeneLoc Exon Structure
|
Expression
for SEL1L2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SEL1L2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAACTGGAAA
About this image
See SEL1L2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SEL1L2
SOURCE GeneReport for Unigene cluster: Hs.590879
SABiosciences Custom PCR Arrays for SEL1L2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEL1L2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SEL1L2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SEL1L2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SEL1L2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEL1L2 |
Orthologs
for SEL1L2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for SEL1L2 gene from 4/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
worm
(Caenorhabditis elegans) |
Secernentea |
sel-16 |
Suppressor/Enhancer of Lin-12 family member (sel-1... |
36(a) |
1 ↔ 1 |
V(12560706-12563367) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G735706AT1G182606 |
Hr.3 like protein |
29(a)28(a) |
many ↔ manymany ↔ many |
1(27650992-27653942) 1(6278848-6282103) |
rice
(Oryza sativa) |
Liliopsida |
-- |
Sel1 repeat domain containing protein, putative, e... |
26(a) |
1 → many |
3(8397755-8404805) |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
ybeT6ybeQ6 |
conserved protein |
24(a)18(a) |
many ↔ manymany ↔ many |
Chromosome(678075-678629) Chromosome(674793-675770) |
ENSEMBL Gene Tree for SEL1L2 (if available)
TreeFam Gene Tree for SEL1L2 (if available) |
Paralogs
for SEL1L2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SEL1L2 gene
- SEL1L32 SEL1L2
1 SIMAP similar gene for SEL1L2 using alignment to 5 protein entries: SE1L2_HUMAN (see all proteins):SEL1L
SEL1L2 for paralogs About GeneDecksing
|
Genomic Variants
for SEL1L2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SEL1L2 (13829893 - 13977089 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for SEL1L2
5 CNVs: 35895 35893 35891 35894 35892
1 Indel: 12159 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SEL1L2 |
|
Disorders
/ Diseases
for SEL1L2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SEL1L2 for disorders About GeneDecksing
OMIM gene information: 614289
OMIM disorders: --
1  disease for SEL1L2: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: SEL1L2 (1 document)
Export disorders for SEL1L2 gene to outside databases
|
Publications
for SEL1L2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SEL1L2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SEL1L2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (2007)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Identification of a region within SEL1L protein required for tumour growth inhibition. (PubMed id 14729273)1 Cattaneo M....Biunno I. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)2 Deloukas P....Rogers J. (2001)
|
External Searches for SEL1L2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SEL1L2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SEL1L2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SEL1L2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SEL1L2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SEL1L2 gene:
Search GeneIP for patents involving SEL1L2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SEL1L2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SEL1L2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SEL1L2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SEL1L2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SEL1L2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SEL1L2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SEL1L2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for SEL1L2 |
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 | | | SEL1L2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEL1L2 |
|  |  |  | | | | Search ThermoFisher Antibodies for SEL1L2 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SEL1L2 |
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