Aliases for SEL1L Gene
External Ids for SEL1L Gene
Previous GeneCards Identifiers for SEL1L Gene
The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for SEL1L Gene
SEL1L (SEL1L ERAD E3 Ligase Adaptor Subunit) is a Protein Coding gene. Diseases associated with SEL1L include good syndrome and neuronal ceroid lipofuscinosis. Among its related pathways are Signaling by GPCR and Transport to the Golgi and subsequent modification. An important paralog of this gene is SEL1L3.
UniProtKB/Swiss-Prot for SEL1L Gene
May play a role in Notch signaling (By similarity). May be involved in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins.