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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SEL1L Gene

protein-coding   GIFtS: 68
GCID: GC14M081937

Sel-1 Suppressor Of Lin-12-Like (C. Elegans)

(Previous names: sel-1 (suppressor of lin-12, C.elegans)-like)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sel-1 Suppressor Of Lin-12-Like (C. Elegans)1 2     SEL1L12
Suppressor Of Lin-12-Like Protein 12 3     Protein Sel-1 Homolog 12
Sel-1 (Suppressor Of Lin-12, C.Elegans)-Like1     Sel-1 Suppressor Of Lin-12-Like 12
Sel-1 Suppressor Of Lin-12-Like 1 (C. Elegans)1     Suppressor Of Lin 12 (Sel-1), C. Elegans, Homolog Of2
PRO10632     Sel-1L3
SEL1-LIKE2     TSA3053

External Ids:    HGNC: 107171   Entrez Gene: 64002   Ensembl: ENSG000000715377   OMIM: 6023295   UniProtKB: Q9UBV23   

Export aliases for SEL1L gene to outside databases

Previous GC identifers: GC14M079443 GC14M075754 GC14M079927 GC14M081007 GC14M062108


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEL1L Gene:
The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation
of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the
proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for SEL1L Gene: 
SEL1L (sel-1 suppressor of lin-12-like (C. elegans)) is a protein-coding gene. Diseases associated with SEL1L include pancreatic ductal carcinoma, and hyperinsulinemic hypoglycemia. GO annotations related to this gene include protein binding. An important paralog of this gene is SEL1L3.

UniProtKB/Swiss-Prot: SE1L1_HUMAN, Q9UBV2
Function: May play a role in Notch signaling (By similarity). May be involved in the endoplasmic reticulum quality
control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of
misfolded endoplasmic reticulum proteins

Gene Wiki entry for SEL1L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SEL1L gene promoter:
         FOXF2   Nkx2-2   LCR-F1   AREB6   CBF-A   E2F   E2F-1   CBF-B   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSEL1L promoter sequence
   Search SABiosciences Chromatin IP Primers for SEL1L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SEL1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q31   Ensembl cytogenetic band:  14q31.1   HGNC cytogenetic band: 14q31

SEL1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEL1L gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M081937:  view genomic region     (about GC identifiers)

Start:
81,937,893 bp from pter      End:
82,000,205 bp from pter
Size:
62,313 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SE1L1_HUMAN, Q9UBV2 (See protein sequence)
Recommended Name: Protein sel-1 homolog 1 precursor  
Size: 794 amino acids; 88755 Da
Subunit: Part of a complex containing SEL1L, SYVN1 and DERL2. May form a complex with ERLEC1, HSPA5, OS9, and
SYVN1. Interacts with FOXRED2 and EDEM1
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein
Secondary accessions: Q6UWT6 Q9P1T9 Q9UHK7
Alternative splicing: 2 isoforms:  Q9UBV2-1   Q9UBV2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SEL1L: NX_Q9UBV2

Explore proteomics data for SEL1L at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UBV2

  • SEL1L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SEL1L Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001231913.1  NP_005056.3  

    ENSEMBL proteins: 
     ENSP00000337053   ENSP00000450709   ENSP00000451144  

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    Cloud-Clone Corp. Proteins for SEL1L 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane NAS--

    SEL1L for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR013806 Kringle-like
     IPR000562 FN_type2_col-bd
     IPR006597 Sel1-like

    Graphical View of Domain Structure for InterPro Entry Q9UBV2

    ProtoNet protein and cluster: Q9UBV2

    2 Blocks protein domains:
    IPB000562 Type II fibronectin collagen-binding domain
    IPB006597 Sel1-like repeat


    UniProtKB/Swiss-Prot: SE1L1_HUMAN, Q9UBV2
    Similarity: Belongs to the sel-1 family
    Similarity: Contains 1 fibronectin type-II domain
    Similarity: Contains 11 Sel1-like repeats


    SEL1L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SE1L1_HUMAN, Q9UBV2
    Function: May play a role in Notch signaling (By similarity). May be involved in the endoplasmic reticulum quality
    control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of
    misfolded endoplasmic reticulum proteins

         Genatlas biochemistry entry for SEL1L:
    sel-1 (suppressor of lin-12,C elegans)-like,negative regulator of the NOTCH pathway, specifically expressed in
    pancreas

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18264092
         
    SEL1L for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for SEL1L:
     Decreased number of cells in m  Synthetic lethal with c-Myc af  Synthetic lethal with imatinib 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sel1l):
     cellular  endocrine/exocrine gland  liver/biliary system  mortality/aging 

    SEL1L for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SEL1L 
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    hsa-miR-140-5p hsa-miR-2052 hsa-miR-4254 hsa-miR-607 hsa-miR-188-5p hsa-miR-4272 hsa-miR-650 hsa-miR-105
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SEL1L About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for SEL1L):
        Protein processing in endoplasmic reticulum


    SEL1L for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SEL1L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/66 Interacting proteins for SEL1L (Q9UBV22, 3 ENSP000003370534) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206286Q8N1B43I2D: score=1 
    ENSG00000224455Q8N1B43I2D: score=1 
    ENSG00000225590Q8N1B43I2D: score=1 
    ENSG00000228425Q8N1B43I2D: score=1 
    ENSG00000236014Q8N1B43I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007219Notch signaling pathway IEA--
    GO:0034976response to endoplasmic reticulum stress IEA--

    SEL1L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SEL1L (SE1L1)

    Search CenterWatch for drugs/clinical trials and news about SEL1L / SE1L1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SEL1L gene (2 alternative transcripts): 
    NM_001244984.1  NM_005065.5  

    Unigene Cluster for SEL1L:

    Sel-1 suppressor of lin-12-like (C. elegans)
    Hs.181300  [show with all ESTs]
    Unigene Representative Sequence: NM_005065
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336735(uc010tvv.2) ENST00000554293 ENST00000555923 ENST00000554744
    ENST00000555824(uc001xvo.4) ENST00000557372

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    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate SEL1L (see all 49):
    hsa-miR-140-5p hsa-miR-2052 hsa-miR-4254 hsa-miR-607 hsa-miR-188-5p hsa-miR-4272 hsa-miR-650 hsa-miR-105
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    Additional mRNA sequence: 

    AB020335.1 AF052059.1 AK075511.1 AK130629.1 AY358651.1 BC040498.1 BC054336.1 U11037.1 

    16 DOTS entries:

    DT.441809  DT.91767327  DT.100792905  DT.97864187  DT.100688206  DT.91790115  DT.100680503  DT.120788936 
    DT.120788947  DT.40189743  DT.101970317  DT.120788954  DT.120788955  DT.120788964  DT.95358021  DT.97797315 

    24/298 AceView cDNA sequences (see all 298):

    AA564969 AI769226 BU073280 BP356980 AL602910 BX487410 AA250915 BM980468 
    BM840600 AI088400 AI249931 CA447284 BP357845 AI640909 AA031823 BM312853 
    AA805468 AI282342 CA946718 BM021417 AA040437 BG498551 AI767632 AY358651 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SEL1L (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a ·
    SP1:                                                        -                             -                 -                             -     -               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:              -                                                                                                                                             
    SP5:                                                                                                                                                            

    ExUns: 19b ^ 20
    SP1:  -         
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for SEL1L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SEL1L expression in normal human tissues (normalized intensities)      SEL1L embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAGACTCTT
    SEL1L Expression
    About this image


    SEL1L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Blood (Respiratory System)    fully expand to see all 3 entries
             neutrophils   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Floor Plate Cells Spinal Floor Plate
             Spinal Floor Plate
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             bronchus ; respiratory epithelial cells   
             alveolar macrophages   

    See SEL1L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SEL1L

    SOURCE GeneReport for Unigene cluster: Hs.181300

    UniProtKB/Swiss-Prot: SE1L1_HUMAN, Q9UBV2
    Tissue specificity: Highly expressed in pancreas

        SABiosciences Expression via Pathway-Focused PCR Arrays including SEL1L: 
              Notch Signaling Pathway in human mouse rat
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SEL1L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SEL1L gene from 9/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sel1l1 , 5 sel-1 suppressor of lin-12-like (C. elegans)1, 5 87.77(n)1
    93.65(a)1
      12 (45.02 cM)5
    203381  NM_001039089.11  NP_001034178.11 
     918060435 
    chicken
    (Gallus gallus)
    Aves SEL1L1 sel-1 suppressor of lin-12-like (C. elegans) 78.36(n)
    84.69(a)
      423391  XM_421303.3  XP_421303.2 
    lizard
    (Anolis carolinensis)
    Reptilia SEL1L6
    sel-1 suppressor of lin-12-like (C. elegans)
    74(a)
    1 ↔ 1
    1(17736669-17774663)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.14422 Xenopus laevis transcribed sequence with moderate similarity more 79.77(n)    CA988511.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.154922 Transcribed sequence with moderate similarity to protein more 79.57(n)    57044715 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:LD235873
    Hrd31
    CG10221-PA1 51(a)3
    56.66(n)1
    53.36(a)1
      95B13
    428061  NM_142922.21  NP_651179.11 
    worm
    (Caenorhabditis elegans)
    Secernentea sel-11 , 3 Yeast hypothetical gene L8167.5 like3
    Protein SEL-11
    46(a)3
    53.98(n)1
    48.12(a)1
      V(12563329-12565654)3
    1797201  NM_073743.41  NP_506144.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HRD3(YLR207W)4 Resident protein of the ER membrane that plays a central more   --   12(556788-559289) 850904  NP_013308.1 
    rice
    (Oryza sativa)
    Liliopsida Os.473192 Oryza sativa (japonica cultivar-group) cDNA clone0 more 79.77(n)    AK063394.1 


    ENSEMBL Gene Tree for SEL1L (if available)
    TreeFam Gene Tree for SEL1L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SEL1L gene
    SEL1L32  SEL1L22  
    1 SIMAP similar gene for SEL1L using alignment to 5 protein entries:     SE1L1_HUMAN (see all proteins):
    SEL1L2

    SEL1L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1370 SNPs in SEL1L are shown (see all 1370)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1818498211,2
    --62922940(+) TCTTCA/TTTAGT 1 -- ds50010--------
    rs1178765141,2
    C,F--62923019(+) CACAGC/ACAGCG 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs1508715981,2
    --62923023(+) GCCAGC/TGTTAG 1 -- ds50010--------
    rs2009005361,2
    --62923059(+) AGAAC-/AAAAAA 1 -- ds50010--------
    rs1394279101,2
    --62923169(+) GGGCTC/TTCACA 1 -- ds50010--------
    rs1870255671,2
    --62923173(+) TTTCAC/TATCCT 1 -- ds50010--------
    rs560171881,2
    C,F--62923200(+) CAAGAT/ACAGAG 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs18523951,2
    C,H--62923221(-) TCAAAT/CGTGGG 1 -- ds500117Minor allele frequency- C:0.01NS EA NA WA CSA 792
    rs1442583751,2
    --62923237(+) GAATCA/GTGTAA 1 -- ds50010--------
    rs118463371,2
    C,H--62923265(+) ATTTTC/TGAAGT 1 -- ds50015Minor allele frequency- T:0.04NS EA NA WA 418

    HapMap Linkage Disequilibrium report for SEL1L (81937893 - 82000205 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SEL1L:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv902120CNV Gain21882294


    Human Gene Mutation Database (HGMD): SEL1L
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SEL1L
    DNA2.0 Custom Variant and Variant Library Synthesis for SEL1L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602329    OMIM disorders: --

    20/24 diseases for SEL1L (see all 24):    About MalaCards
    pancreatic ductal carcinoma    hyperinsulinemic hypoglycemia    hypoglycemia    neuronal ceroid lipofuscinosis
    autoimmune thyroiditis    esophageal cancer    noma    graves' disease
    pancreatic cancer    pancreatitis    ulcerative colitis    diabetes mellitus
    inflammatory bowel disease    esophagitis    hypoxia    thyroiditis
    gastric cancer    adenocarcinoma    alzheimer's disease    squamous cell carcinoma

    2 diseases from the University of Copenhagen DISEASES database for SEL1L:
    Ulcerative colitis     Crohn's disease

    SEL1L for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10 Novoseek inferred disease relationships for SEL1L gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aggressive behavior 36.9 2 16331889 (1), 14729273 (1)
    pancreatic cancer 33.5 5 16331889 (2), 10763137 (1), 15355917 (1)
    graves disease 33 2 12030374 (1)
    aggressiveness 32.6 3 11809711 (2), 16331677 (1)
    breast carcinoma 30.5 7 11809711 (3), 15880780 (2), 14729273 (1)
    diabetes mellitus insulin-dependent 22 2 11544613 (2)
    carcinoma squamous cell 16.1 3 17822620 (2), 15355917 (1)
    adenocarcinoma 13.6 2 9417916 (1), 16623793 (1)
    tumors 3.27 23 17822620 (6), 11809711 (3), 16647946 (2), 16331677 (2) (see all 7)
    cancer 0 4 15355917 (3), 16331677 (1)

    Genetic Association Database (GAD): SEL1L
    Human Genome Epidemiology (HuGE) Navigator: SEL1L (5 documents)

    Export disorders for SEL1L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SEL1L gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with SEL1L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. No evidence for SEL1L as a candidate gene for IDDM11-conferred susceptibility. (PubMed id 11544613)1, 4, 9 Pociot F....Cucca F. (2001)
    2. SEL1L a multifaceted protein playing a role in tumor progression. (PubMed id 16331677)1, 3, 9 Biunno I....Menard S. (2006)
    3. SEL1L microsatellite polymorphism in Japanese patients with autoimmune thyroid diseases. (PubMed id 11349831)1, 4, 9 Ban Y....Ban Y. (2001)
    4. Allele frequency of two intragenic microsatellite loci of SEL1L gene in Northern Italian population. (PubMed id 12030374)1, 4, 9 Chiaramonte R....Sherbet G.V. (2002)
    5. Complete cDNA sequence and genomic organization of a human pancreas- specific gene homologous to Caenorhabditis elegans sel-1. (PubMed id 10496078)1, 2, 9 Harada Y.... Tanigami A. (1999)
    6. OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. (PubMed id 18264092)1, 2, 9 Christianson J.C.... Kopito R.R. (2008)
    7. SEL1L, the human homolog of C. elegans sel-1: refined physical mapping, gene structure and identification of polymorphic markers. (PubMed id 10746565)1, 2, 9 Biunno I.... Zollo M. (2000)
    8. Isolation of a pancreas-specific gene located on human chromosome 14q31: expression analysis in human pancreatic ductal carcinomas. (PubMed id 9417916)1, 3, 9 Biunno I.... Sgaramella V. (1997)
    9. Identification of type 2 diabetes-associated combinat ion of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (2010)
    10. EDEM1 recognition and delivery of misfolded proteins to the SEL1L- containing ERAD complex. (PubMed id 19524542)1, 2 Cormier J.H.... Hebert D.N. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6400 HGNC: 10717 AceView: SEL1L Ensembl:ENSG00000071537 euGenes: HUgn6400
    ECgene: SEL1L Kegg: 6400 H-InvDB: SEL1L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SEL1L Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SEL1L Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SEL1L gene:
    Search GeneIP for patents involving SEL1L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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