Aliases for SEL1L Gene
External Ids for SEL1L Gene
Previous GeneCards Identifiers for SEL1L Gene
The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for SEL1L Gene
SEL1L (SEL1L ERAD E3 Ligase Adaptor Subunit) is a Protein Coding gene. Diseases associated with SEL1L include good syndrome and diabetes mellitus, insulin-dependent. Among its related pathways are Protein processing in endoplasmic reticulum and Transport to the Golgi and subsequent modification. An important paralog of this gene is SEL1L3.
UniProtKB/Swiss-Prot for SEL1L Gene
May play a role in Notch signaling (By similarity). May be involved in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins.